HOME ＞ 研究業績詳細
研究業績詳細
名黒 功（ナグロ イサオ）
| 研究テーマ | 細胞のストレス応答の分子基盤解明 |
|---|---|
| 研究業績（論文） | 1. Ryuno, H., Hanafusa, Y., Fujisawa, T., Ogawa, M., Adachi, H., Naguro, I.* and Ichijo, H. HES1 potentiates high salt stress response as an enhancer of NFAT5-DNA binding. Commun., Biol., 7, 1290 (2024). doi: 10.1038/s42003-024-06997-7 2. Yamauchi, S.*, Sugiura, Y., Yamaguchi, J., Zhou, X., Takenaka, S., Odawara, T., Fukaya, S., Fujisawa, T., Naguro, I., Uchiyama, Y., Takahashi, A. and Ichijo, H.* DNA damage-activated mitochondrial fatty acid oxidation drives senescence. Sci. Adv., 10, eado5887 (2024). doi: 10.1126/sciadv.ado5887 3. Zhang, Y., Naguro, I., Ryuno, H. and Herr, A.* Contact Blot: microfluidic control and measurement of cell-cell contact state to assess contact-inhibited ERK signaling. Anal. Chem., 96, 15330-15337 (2024). doi: 10.1021/acs.analchem.4c02936. 4. Ito, S., Kuromiya, K., Sekai, M., Sako, H., Sai, K., Morikawa, R., Mukai, Y., Ida, Y., Anzai, M., Ishikawa, S., Kozawa, K., Shirai, T., Tanimura, N., Sugie, K., Ikenouchi. J., Ogawa, M., Naguro, I., Ichijo, H., and Fujita. Y.* Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells. Proc. Natl. Acad. Sci. U.S.A., 120, e2307118120 (2023). doi: 10.1073/pnas.2307118120. 5. Morishita, K., Watanabe, K.*, Naguro, I.*, and Ichijo, H. Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response. Cell Rep., 42, 112315 (2023). doi: 10.1016/j.celrep.2023.112315. 6. Ikizawa, T., Ikeda, T., Arita, M., Kitajima, S., Soga, T., Ichijo, H.*, and Naguro, I.* Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase (PDH) phosphorylation. J. Biol. Chem., 299, 102837 (2023). doi: 10.1016/j.jbc.2022.102837. 7. Nishida, T., Naguro, I.*, and Ichijo, H.* NAMPT-dependent NAD+ salvage is crucial for the decision between apoptotic and necrotic cell death under oxidative stress. Cell Death Discov., 8, 195 (2022). doi: 10.1038/s41420-022-01007-3. 8. Yoshitane, H.*, Imamura, K., Okubo, T., Otobe, Y., Kawakami, S., Ito, S., Takumi, T., Hattori, K., Naguro, I., Ichijo, H., and Fukada, Y.* mTOR-AKT signaling in cellular clock resetting triggered by osmotic stress. Antioxd. Redox Signal., 37, 631-646 (2022). doi: 10.1089/ars.2021.0059. 9. Watanabe, K.*, Morishita, K., Zhou, X., Siizaki, S., Uchiyama, Y., Koike, M., Naguro, I., and Ichijo, H.* Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose). Nat. Commun., 12, 1353 (2021). doi: 10.1038/s41467-021-21614-5. 10. Takayanagi, S., Watanabe, K.*, Maruyama, T., Ogawa, M., Morishita, K., Soga, M., Hatta, T., Natsume, T., Hirano, T., Kagechika, H., Hattori, K., Naguro, I. and Ichijo, H.* ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes. Sci. Rep., 11, 22009 (2021). doi: 10.1038/s41598-021-01123-7. 11. Matsui, H., Iriyama, T.*, Sayama, S., Inaoka, N., Suzuki, K., Yoshikawa, M., Ichinose, M., Sone, K., Kumasawa, K., Nagamatsu, T., Fujisawa, T., Naguro, I., Ichijo, H., Fujii, T. and Osuga, Y. Elevated placental hisotone H3K4 methylation via upregulation histone methyltransferase SETD1A and SMYD3 in preeclampsia and possible involvement in hypoxia-induced pathophysiological process. Placenta, 115, 60-69 (2021). doi: 10.1016/j.placenta.2021.09.009. 12. Nakamura, T., Ogawa, M., Kojima, K., Takayanagi, S., Ishihara, S., Hattori, K., Naguro, I.*, and Ichijo, H.* The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress-induced ferroptosis. EMBO Rep., 22, e51532 (2021). doi: 10.15252/embr.202051532. 13. Fujimoto, M., Kamiyama, M.*, Fuse, K., Ryuno, H., Odawara, T., Furukawa, N., Yishimatsu, Y., Watabe, T., Prchal-Murphy, M., Sexl, V., Tahara, H., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I., and Ichijo, H.* ASK1 suppresses NK cell-mediated intravascular tumor cell clearance in lung metastasis. Cancer Sci., 112, 1633-1643 (2021). doi: 10.1111/cas.14842. 14. Ogawa, M., Kawarazaki, Y., Fujita, Y., Naguro, I.* and Ichijo, H.* FGF21 induced by the ASK1-p38 pathway promotes mechanical cell competition by attracting cells. Curr. Biol., 31, 1048-1057 (2021). doi: 10.1016/j.cub.2020.11.052. 15. De Blasio, C., Verma, N., Moretti,M., Cialfi, S., Zonfrilli, A., Franchitto, M., Truglio, F., De Smaele, E., Ichijo, H., Naguro, I., Screpaniti, I and Talora, C.* Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell cycle arrest, cell death and tumorigenesis of stressed keratinocytes. Cell Death Discov., 7, 75 (2021). doi: 10.1038/s41420-021-00459-3. 16. Kojima, K., Ichijo, H.* and Naguro, I. Molecular functions of ASK family in diseases caused by stress-induced inflammation and apoptosis. J. Biochem., 169, 395-407 (2021). doi: 10.1093/jb/mvaa145. 17. Ito-Kureha, T., Miyao, T., Nishijima, S., Suzuki, T., Koizumi, S., Villar-Briones, A., Takahashi, A., Akiyama, N., Morita, M., Naguro, I., Ishikawa, H., Ichijo, H., Akiyama, T.* and Yamamoto, T.* The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression. Nat. Commun., 11, 6169 (2020). doi: 10.1038/s41467-020-19975-4. 18. Ishida-Ishihara, S., Akiyama, M., Furusawa, K., Naguro, I., Ryuno, H., Sushida, T., Ishihara, S. and Haga, H*. Osmotic gradients induce stable dome morphogenesis on extracellular matrix. J. Cell Sci., 133, jcs243865 (2020). doi: 10.1242/jcs.243865. 19. Yoshikawa, M., Iriyama*, T., Suzuki, K., Sayama, S., Tsuruga, T., Kumasawa, K., Nagamatsu, T., Homma, K., Naguro, I., Osuga, Y., Ichijo, H. and Fujii, T. ASK1 promotes uterine inflammation leading to pathological preterm birth. Sci. Rep., 10, 1887 (2020). doi: 10.1038/s41598-020-58653-9. 20. Homma, K.*, Takahashi, H., Tsuburaya, N., Naguro, I., Fujisawa, T. and Ichijo, H. Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase. J. Biol. Chem., 295, 3148-3158 (2020). doi: 10.1074/jbc.RA119.010239. 21. Zhang, Y., Naguro, I. and Herr, A.* In situ single-cell western blot on adherent cell culture. Angew. Chem. Int. Ed. Engl., 58, 13929-13934 (2019). doi: 10.1002/anie.201906920. 22. Nakamura, T., Naguro, I.* and Ichijo, H. Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases. Biochim. Biophys. Acta. Gen. Subj., 1863, 1398-1409 (2019). doi: 10.1016/j.bbagen.2019.06.010. 23. Ryuno, H., Nigo, F., Naguro, I., Sekimizu, K., and Kaito, C.* Staphylococcus aureus aggregation in the plasma fraction of silkworm hemolymph. PLoS One., 14, e0217517 (2019). doi: 10.1371/journal.pone.0217517. 24. Kamiyama, M., Naguro, I. and Ichijo, H.* Functional analysis of Apoptosis Signal-regulating Kinase family in a murine model of tumor metastasis. Yakugaku Zasshi, 139, 743-751 (2019) (Japanese). doi: 10.1248/yakushi.18-00185-2. 25. Tsuburaya, N., Homma, K., Higuchi, T., Balia, A., Yamakoshi, H., Shibata, N., Nakamura, S., Nakagawa, H., Ikeda, S. I., Umezawa, N., Kato, N., Yokoshima, S., Shibuya, M., Shimonishi, M., Kojima, H., Okabe, T., Nagano, T., Naguro, I., Imamura, K., Inoue, H., Fujisawa, T. and Ichijo, H.* A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat. Commun., 9, 2668 (2018). doi: 10.1038/s41467-018-05127-2. 26. Cheng, R., Takeda, K., Naguro, I., Hatta, T., Iemura, S., Natsume, T., Ichijo, H.* and Hattori, K.* beta-TrCP-dependent degradation of ASK1 suppresses the induction of the apoptotic response by oxidative stress. Biochim. Biophys. Acta, 1862, 2271-2280 (2018). doi: 10.1016/j.bbagen.2018.07.015. 27. Imamura, K., Yoshitane, H.*, Hattori, K., Yamaguchi, M., Yoshida, K., Okubo, T., Naguro, I., Ichijo, H. and Fukada, Y.* ASK family kinases mediate cellular stress and redox signaling to circadian clock. Proc. Natl. Acad. Sci. U.S.A., 115, 3646-3651 (2018). doi: 10.1073/pnas.1719298115. 28. Watanabe, K., Umeda, T., Niwa, K., Naguro, I.* and Ichijo, H.* A PP6-ASK3 module coordinates the bidirectional cell volume regulation under osmotic stress. Cell Rep., 22, 2809-2817 (2018). doi: 10.1016/j.celrep.2018.02.045. 29. Kamiyama, M., Naguro, I. and Ichijo, H.* mASKing cancer cells in a tumor microenvironment. Cell Cycle, 17, 139-140 (2018). doi: 10.1080/15384101.2017.1407402. 30. Hirata, Y., Katagiri, K., Nagaoka, K., Morishita, T., Kudoh, Y., Hatta, T., Naguro, I., Kano, K., Udagawa, T., Natsume, T., Aoki, J., Inada, T., Noguchi, T., Ichijo, H. and Matsuzawa, A.* TRIM48 promotes ASK1 activation and cell death through ubiquitination-dependent degradation of the ASK1-negative regulator PRMT1. Cell Rep., 21, 2447-2457 (2017). doi: 10.1016/j.celrep.2017.11.007. 31. Hattori, K., Ishikawa, H., Sakauchi, C., Takayanagi, S., Naguro, I. and Ichijo, H.* Cold stress-induced ferroptosis involves the ASK1-p38 pathway. EMBO Rep., 18, 2067-2078 (2017). doi: 10.15252/embr.201744228. 32. Kamiyama, M., Shirai, T., Tamura, S., Suzuki-Inoue, K., Ehata, S., Takahashi, K., Miyazono, K., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I. and Ichijo, H.* ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets. Cell Death Differ., 24, 2066-2076 (2017). doi: 10.1038/cdd.2017.114. 33. Maruoka, S., Gon*, Y., Mizumura, K., Okamoto, S., Tsuya, K., Shikano, S., Soda, K., Naguro, I., Ichijo, H. and Hashimoto, S. Involvement of apoptosis signal-regulating kinase-1 in house dust mite-induced allergic asthma in mice. Allergol. Int., 66, S50-S52 (2017). doi: 10.1016/j.alit.2017.05.007. 34. Ryuno, H., Naguro, I. and Kamiyama, M.* ASK family and cancer. Adv. Biol. Regul., 66, 72-84 (2017). doi: 10.1016/j.jbior.2017.05.003. 35. Naguro, I.* Analysis of ASK3 that regulates bidirectional osmotic stress response. Seikagaku, 89, 230-240 (2017) (Japanese). doi: 10.14952/SEIKAGAKU.2017.890230. 36. Yamaguchi, N., Sekine, S., Naguro, I., Sekine, Y. and Ichijo, H.* KLHDC10 deficiency protects mice against TNF alpha-induced systemic inflammation. PLoS One, 11, e0163118 (2016). doi: 10.1371/journal.pone.0163118. 37. Koizumi, S., Irie, T., Hirayama, S., Sakurai, Y., Yashiroda, H., Naguro, I., Ichijo, H., Hamazaki, J. and Murata, S.* The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. Elife, 5, pii: e18357 (2016). doi: 10.7554/eLife.18357. 38. Zhou, X., Naguro, I., Ichijo, H.* and Watanabe, K. Mitogen-activated protein kinases as key players in osmotic stress signaling. Biochim. Biophys. Acta., 1860, 2037-2052 (2016). doi: 10.1016/j.bbagen.2016.05.032. 39. Sekine, S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K. and Ichijo, H.* The ablation of mitochondrial protein phosphatase Pgam5 confers resistance against metabolic stress. EBioMedicine, 5, 82-92 (2016). doi: 10.1016/j.ebiom.2016.01.031. 40. Hattori, K., Naguro, I., Okabe, K., Funatsu, T., Furutani, S., Takeda, K. and Ichijo, H.* ASK1 signalling regulates brown and beige adipocyte function. Nat. Commun., 7, 11158 (2016). doi: 10.1038/ncomms11158. 41. Maruyama, J., Kobayashi, Y., Umeda, T., Vandewalle, A., Ichijo, H. and Naguro, I.* Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway. Sci. Rep., 6, 18710 (2016). doi: 10.1038/srep18710. 42. Fujisawa, T., Takahashi, M., Tsukamoto, Y., Yamaguchi, N., Nakoji, M., Endo, M., Kodaira, H., Hayashi, Y., Nishitoh, H., Naguro, I., Homma, K. and Ichijo, H.* The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis. Hum. Mol. Genet., 25, 245-253 (2016). doi: 10.1093/hmg/ddv467. 43. Fujisawa, T., Yamaguchi, N., Kadowaki, H., Tsukamoto, Y., Tsuburaya, N., Tsubota, A., Takahashi, H., Naguro, I., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H., Homma, K. and Ichijo, H.* A systematic immunoprecipitation approach reinforces the concept of common conformational alterations in amyotrophic lateral sclerosis-linked SOD1 mutants. Neurobiol. Dis., 82, 478-486 (2015). doi: 10.1016/j.nbd.2015.08.010. 44. Kamiyama, M., Naguro, I. and Ichijo, H.* In vivo gene manipulation reveals the impact of stress-responsive MAPK pathways on tumor progression. Cancer Sci., 106, 785-796 (2015). doi: 10.1111/cas.12676. 45. Watanabe, T., Sekine, S., Naguro, I., Sekine, Y. and Ichijo, H.* Apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress-induced necrosis. J. Biol. Chem., 290, 10791-10803 (2015). doi: 10.1074/jbc.M1114.623280. 46. Machida, T., Ichijo, H. and Naguro, I. Regulation of cellular signalling by thioredoxin. In: Louro, R. O. and Diaz-Moreno, I. (eds.) Redox proteins in supercomplexes and signalosomes, Chapter 11, 255-274, CRC Press (2015). 47. Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A., Takeda, K., Naguro, I. and Ichijo, H.* The DEAH-box RNA helicase DHX15 activates NF-kappa B and MAPK signaling downstream of MAVS during antiviral responses. Sci. Signal., 7, ra40 (2014). doi: 10.1126/scisignal.2004841. 48. Kawarazaki, Y., Ichijo, H.* and Naguro I. Apoptosis signal-regulating kinase 1 as a therapeutic target. Expert Opin. Ther. Targets, 18, 651-664 (2014). doi: 10.1517/14728222.2014.896903. 49. Maruyama, T., Arakai, T., Kawarazaki, Y., Naguro, I., Heynen, S., Aza-Blanc, P., Ronai, Z., Matsuzawa, A. and Ichijo, H.* Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Sci. Signal., 7, ra8 (2014). doi: 10.1126/scisignal.2004822. 50. Homma, K., Fujisawa, T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I. and Ichijo, H.* SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency. Mol. Cell, 52, 75-86 (2013). doi: 10.1016/j.molcel.2013.08.038. 51. Shiizaki, S., Naguro, I. and Ichijo, H.* Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling. Adv. Biol. Regul., 53, 135-144 (2013). doi: 10.1016/j.jbior.2012.09.006. 52. Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama, S., Uchida, S., Vandewalle, A., Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K. and Ichijo, H.* ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. Nat. Commun., 3, 1285 (2012). doi: 10.1038/ncomms2283. 53. Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H.* A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants. Ann. Neurol., 72, 793-749 (2012). doi: 10.1002/ana.23668. 54. Sekine, Y., Takagahara, S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H.* p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. J. Cell Sci., 124, 3006-3016 (2011). doi: 10.1242/jcs.085902. 55. Takeda, K.*, Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H.* Apoptosis signaling kinases: from stress response to health outcomes. Antioxid. Redox Signal., 15, 719-761 (2011). doi: 10.1089/ars.2010.3392. 56. Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo, H.* CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J., 29, 2501-2514 (2010). doi: 10.1038/emboj.2010.141. 57. Hattori, K., Naguro, I., Runchel, C. and Ichijo, H.* The roles of ASK family proteins in stress responses and diseases. Cell Communication and Signaling, 7, 9 (2009). doi: 10.1186/1478-811X-7-9. 58. Maruyama, J., Naguro, I., Takeda, K. and Ichijo, H.* Stress-Activated MAP Kinase Cascades in Cellular Senescence. Curr. Med. Chem., 16, 1229-1235 (2009). doi: 10.2174/092986709787846613. 59. Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo, H.* ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J., 28, 843-853 (2009). doi: 10.1038/emboj.2009.32. 60. Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K. and Ichijo, H.* Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. J. Biol. Chem., 283, 7657-7665 (2008). doi: 10.1074/jbc.M708402200. 61. Takeda, K., Noguchi, T., Naguro, I. and Ichijo, H.* Apoptosis Signal-regulating Kinase 1 (ASK1) in stress and immune response. Annu. Rev. Pharmacol. Toxicol., 48, 199-225 (2008). doi: 10.1146/annurev.pharmtox.48.113006.094606. 62. Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A. and Ichijo, H.* Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. J. Biol. Chem., 282, 7522-7531 (2007). doi: 10.1074/jbc.M607177200. 63. Yokoyama, U., Minamisawa, S., Adachi-Akahane, S., Akaike, T., Naguro, I., Funakoshi, K., Iwamoto, M., Nakagome, M., Uemura, N., Hori, H., Yokota, S. and Ishikawa, Y.* Multiple transcripts of Ca2+ channel a1 subunits and a novel spliced variant of the alpha1C-subunit in rat ductus arteriosus. Am. J. Physiol. Heart Circ. Physiol. 290, H1660-H1670 (2006). doi: 10.1152/ajpheart.00100.2004. 64. Naguro, I., Adachi-Akahane, S. and Ichijo, H.* Calcium signaling via voltage-dependent L-type Ca2+ channels. Signal Transduction, 4, 195-205 (2004). 65. Naguro, I., Nagao, T. and Adachi-Akahane, S.* Ser1901 of alpha1 subunit is required for the PKA-mediated enhancement of L-type Ca2+ channel currents but not for the negative shift of activation. FEBS Lett., 489, 87-91 (2001). doi: 10.1016/s0014-5793(01)02079-8. |
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