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研究業績詳細
小松 雅明（コマツ マサアキ）
| 研究テーマ | オートファジー、タンパク質修飾 |
|---|---|
| 研究業績（論文） | 1. Komatsu M*, Inada T*, Noda NN*. The UFM1 system: Working principles, cellular functions, and pathophysiology. Mol Cell. 84:156-169 (2024). 2. Ishimura R#, Ito S#, Mao G, Komatsu-Hirota S, Inada T*, Noda NN*, Komatsu M*. Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control. Sci Adv. 9:eadh3635 (2023). 3. Ikeda R, Noshiro D, Morishita H, Takada S, Kageyama S, Fujioka Y, Funakoshi T, Komatsu-Hirota S, Arai R, Ryzhii E, Abe M, Koga T, Motohashi H, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura Y*, Noda NN*, Komatsu M*. Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response. EMBO J. 42:e113349 (2023). 4. #Kurusu R, #Fujimoto Y, #Morishita H*,… Komatsu M* (19 of 19). Integrated proteomics identifies p62–dependent selective autophagy of the supramolecular vault complex. Dev Cell S1534-5807(23)00191-0 (2023). 5. Ishimura R,… Komatsu M* (20 of 20). The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun. 2022 Dec 21;13(1):7857. 6. Kageyama S, Gudmundsson SR, Sou YS, Ichimura Y, Tamura N, Kazuno S, Ueno T, Miura Y, Noshiro D, Abe M, Mizushima T, Miura N, Okuda S, Motohashi H, Lee JA, Sakimura K, Ohe T, Noda NN, Waguri S, *Eskelinen EL, *Komatsu M. p62/SQSTM1-droplet serves as a platform for autophagosome formation and anti-oxidative stress response. Nat Commun. 12:16 (2021). 7. Sánchez-Martín P, Sou YS, Kageyama S, Koike M, Waguri S, Komatsu M. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. EMBO Rep. 21: e48902 (2020). 8. Saito, T., et al. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat. Commun 10: 1567 (2019). 9. Nahorski MS et al., Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development. BRAIN 141: 1934 (2018). 10. *Ueno, T. & *Komatsu, M. Autophagy in the liver: its functions in health and disease. Nat Rev Gastroenterol Hepatol 14: 170 (2017) * co-correspondence authors. 11. **Muona M, **Ishimura R. et al. Biallelic variants in UBA5 link dysfunctional UFM1 ubiquitin-like modifier pathway to severe infantile-onset encephalopathy. Am J Hum Genet. 99: 683 (2016) ** equal contribution. 12. Saito, T. et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat. Commun 7: 12030 (2016) 13. Ichimura, Y. et al. Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. Mol Cell 51: 618 (2013) 14. *Mizushima, N. & *Komatsu, M. Autophagy: renovation of cells and tissues. Cell 147: 728 (2011) * co-correspondence authors. 15. Tatsumi, K. et al. The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat Commun 2:181 (2011) 16. **Takamura, A. **Komatsu, M. et al. Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25: 795 (2011) ** equal contribution. 17. Inami, Y. et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol 193: 275 (2011) 18. *Komatsu, M. et al. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol 12: 213 (2010) 19. Ichimura, Y. et al. Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem 283: 22847 (2008) 20. Komatsu, M. et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131: 1149 (2007) 21. Komatsu, M. et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A 104: 14489 (2007) 22. Komatsu, M. et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880 (2006) 23. Komatsu, M. et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169: 425 (2005) 24. Komatsu, M. et al. A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J 23: 1977 (2004) |
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