学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

南野徹（ミナミノトオル）

研究テーマ	循環器内科学
研究業績（論文）	BIBLIOGRAPHY（selected) Original articles: 1. Katsuumi G, Shimizu I, Suda M, Yoshida Y, Furihata T, Joki Y, Hsiao CL, Jiaqi L, Fujiki S, Abe M, Sugimoto M, Soga T, Minamino T. SGLT2 inhibition eliminates senescent cells and alleviates pathological aging. Nat Aging. 2024 Jul;4(7):926-938. doi: 10.1038/s43587-024-00642-y. 2. Hsiao YT, Yoshida Y, Okuda S, Abe M, Mizuno S, Takahashi S, Nakagami H, Morishita R, Kamimura K, Terai S, Aung TM, Li J, Furihata T, Tang JY, Walsh K, Ishigami A, Minamino T, Shimizu I. PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. EMBO J. 2024 Nov;43(21):4846-4869. doi: 10.1038/s44318-024-00196-0. 3. Inoue S, Ko T, Shindo A, Nomura S, Yamada T, Jimba T, Dai Z, Nakao H, Suzuki A, Kashimura T, Iwahana T, Goto K, Matsushima S, Ishida J, Amiya E, Zhang B, Kubota M, Sawami K, Heryed T, Yamada S, Katoh M, Katagiri M, Ito M, Nayakama Y, Fujiu K, Hatano M, Takeda N, Takimoto E, Akazawa H, Morita H, Yamaguchi J, Inomata T, Kobayashi Y, Minamino T, Tsutsui H, Kurokawa M, Aiba A, Aburatani H, Komuro I. Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy. JACC Basic Transl Sci. 2024 Jun 12;9(8):956-967. doi: 10.1016/j.jacbts.2024.04.010. 4. Tanaka A, Kida K, Matsue Y, Imai T, Suwa S, Taguchi I, Hisauchi I, Teragawa H, Yazaki Y, Moroi M, Ohashi K, Nagatomo D, Kubota T, Ijichi T, Ikari Y, Yonezu K, Takahashi N, Toyoda S, Toshida T, Suzuki H, Minamino T, Nogi K, Shiina K, Horiuchi Y, Tanabe K, Hachinohe D, Kiuchi S, Kusunose K, Shimabukuro M, Node K. In-hospital initiation of angiotensin receptor-neprilysin inhibition in acute heart failure: the PREMIER trial. Eur Heart J. 2024 Nov 8;45(42):4482-4493. doi: 10.1093/eurheartj/ehae561. 5. Fontana M, Berk JL, Gillmore JD, Witteles RM, Grogan M, Drachman B, Damy T, Garcia-Pavia P, Taubel J, Solomon SD, Sheikh FH, Tahara N, González-Costello J, Tsujita K, Morbach C, Pozsonyi Z, Petrie MC, Delgado D, Van der Meer P, Jabbour A, Bondue A, Kim D, Azevedo O, Hvitfeldt Poulsen S, Yilmaz A, Jankowska EA, Algalarrondo V, Slugg A, Garg PP, Boyle KL, Yureneva E, Silliman N, Yang L, Chen J, Eraly SA, Vest J, Maurer MS; HELIOS-B Trial Investigators. Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy. N Engl J Med. 2024 Aug 30. doi: 10.1056/NEJMoa2409134. 6. Fujiki S, Iijima K, Nakagawa Y, Takahashi K, Okabe M, Kusano K, Owada S, Kondo Y, Tsujita K, Shimizu W, Tomita H, Watanabe M, Shoda M, Watanabe M, Tokano T, Murohara T, Kaneshiro T, Kato T, Hayashi H, Maemura K, Niwano S, Umemoto T, Yoshida H, Ota K, Tanaka T, Kitamura N, Node K, Minamino T; EMPA ICD investigators. Effect of empagliflozin on ventricular arrhythmias in patients with type 2 diabetes treated with an implantable cardioverter-defibrillator: the EMPA-ICD trial. Cardiovasc Diabetol. 2024 Jun 28;23(1):224. doi: 10.1186/s12933-024-02309-9. 7. Furuuchi R, Shimizu I, Yoshida Y, Katsuumi G, Suda M, Kubota Y, Walsh K, Minamino T. Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue. iScience. 2022 Oct 20;25(11):105424. doi: 10.1016/j.isci.2022.105424. 8. Yoshida Y, Shimizu I, Shimada A, Nakahara K, Yanagisawa S, Kubo M, Fukuda S, Ishii C, Yamamoto H, Ishikawa T, Kano K, Aoki J, Katsuumi G, Suda M, Ozaki K, Yoshida Y, Okuda S, Ohta S, Okamoto S, Minokoshi Y, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T, Minamino T. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Sci Rep. 2022 Sep 1;12(1):14883. doi: 10.1038/s41598-022-19245-x. 9. Hayashi Y, Shimizu I, Yoshida Y, Ikegami R, Suda M, Katsuumi G, Fujiki S, Ozaki K, Abe M, Sakimura K, Okuda S, Hayano T, Nakamura K, Walsh K, Jespersen N, Nielsen S, Scheele C, Minamino T. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity. iScience 2022; 25(7): 104547. doi: 10.1016/j.isci.2022.104547. 10. Yoshida Y, Shimizu I, Hsiao Y-H, Suda M, Katsuumi G, Seki M, Suzuki Y, Okuda S, Soga T, and Minamino T. Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue. iScience 2022; 25(5): 104268. doi: 10.1016/j.isci.2022.104268. 11. Park N, Marquez J, Pham TK, Ko TH, Youm JB, Kim M, Choi SH, Moon J, Flores J, Ko KS, Rhee BD, Shimizu I, Minamino T, Du Ha J, Hwang JY, Yang SJ, Park CS, Kim HK, Han J. Cereblon contributes to cardiac dysfunction by degrading Cav1.2α. Eur Heart J. 2022 May 21;43(20):1973-1989. doi: 10.1093/eurheartj/ehac072. 12. Suda M, Shimizu I, Katsuumi G, Yoshida Y, Matsumoto N, Hayashi Y, Ikegami R, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Nakanishi-Matsui M, Minamino T. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging. 2021; 1: 1117–1126. doi:10.1038/s43587-021-00151-2. 13. Nakao M, Shimizu I, Katsuumi G, Yoshida Y, Suda M, Hayashi Y, Ikegami R, Hsiao YT, Okuda S, Soga T, Minamino T. Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload. Sci Rep. 2021; 11(1): 18384. doi: 10.1038/s41598-021-97787-2. 14. Hsiao YT, Shimizu I, Wakasugi T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Izumi D, Kashimura T, Ozaki K, Soga T, Minamino T. Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy. Sci Rep. 2021; 11(1): 6722. doi: 10.1038/s41598-021-86209-y. 15. Fujiki S, Iijima K, Okabe M, Niwano S, Tsujita K, Naito S, Ando K, Kusano K, Kato R, Nitta J, Miura T, Mitsuhashi T, Kario K, Kondo Y, Ieda M, Hagiwara N, Murohara T, Takahashi K, Tomita H, Takeishi Y, Anzai T, Shimizu W, Watanabe M, Morino Y, Kato T, Tada H, Nakagawa Y, Yano M, Maemura K, Kimura T, Yoshida H, Ota K, Tanaka T, Kitamura N, Node K, Aizawa Y, Shimizu I, Izumi D, Ozaki K, Minamino T; EMPA-ICD investigators. Placebo-Controlled, Double-Blind Study of Empagliflozin (EMPA) and Implantable Cardioverter-Defibrillator (EMPA-ICD) in Patients with Type 2 Diabetes (T2DM): Rationale and Design. Diabetes Ther. 2020; 11(11): 2739-2755. 16. Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T. Prolyl isomerase Pin1 suppresses thermogenic programs in adipocytes by promoting degradation of transcriptional co-activator PRDM16. Cell Rep. 2019; 26: 3221-3230. 17. Yokoyama M, Shimizu I, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol. 2019; 129: 105-117. 18. Wakasugi T, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Nakao M, Hoyano M, Kashimura T, Nakamura K, Ito H, Nojiri T, Soga T, Minamino T. Role of smooth muscle cell p53 in pulmonary arterial hypertension. PLoS One. 2019; 14: e0212889. 19. Yoshida Y, Shimizu I, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagami H, Morishita R, Minamino T. Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity. Sci Rep. 2019; 9: 3858. 20. Ikegami R, Shimizu I, Sato T, Yoshida Y, Hayashi Y, Suda Ma, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Zenius Jespersen N, Scheele C, Soga T, Minamino T. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic derangement in obesity. Cell Rep. 2018: 24: 2827-2837. 21. Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S, Minamino T, Oike Y, Hokari R, and Kanai T. Aortic carboxypeptidase–like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis. J Clin Invest. 2018; 128: 1581-1596. 22. Furuuchi R, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLoS One. 2018; 13: e0202051. 23. Kayamori H, Shimizu I, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T. Amlodipine inhibits vascular cell senescence and protects against atherogenesis through the mechanism independent of calcium channel blockade. Int Heart J. 2018; 59: 607-613. 24. Katsuumi G, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T. Catecholamine-induced senescence of endothelial cells and bone marrow cells promotes cardiac dysfunction in mice. Int Heart J. 2018; 59: 837-844. 25. Suda M, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. PLoS One. 2017; 12: e0182422. 26. Nishiuchi S, Makiyama T, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T. Gene-based risk stratification for cardiac disorders in LMNA mutation carriers. Circ Cardiovasc Genet. 2017; 10. pii: e001603. doi:10.1161/CIRCGENETICS.116.001603. 27. Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AA, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N. Variants in the SCN5A promoter associated with various arrhythmia phenotypes. J Am Heart Assoc. 2016; 5. doi: 10.1161/JAHA.116.003644. 28. Yoshida Y, Shimizu I, Katsuumi G, Jiao S, Suda M, Hayashi Y, Minamino T. p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload. J Mol Cell Cardiol. 2015; 85: 183-198. 29. Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I. Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling. Nat Commun. 2015; 6: 6241. 30. Suzuki H, Kayama Y, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T, Tojo K, Minamino T, Yoshimura M, Utsunomiya K. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy. Diabetes 2015; 64: 618-630. 31. Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I, Miki T, Kobayashi Y, Minamino T. Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. NPJ Aging Mech Dis. 2015; 1: 15009. 32. Ito TK, Yokoyama M, Yoshida Y, Nojima A, Kassai H, Oishi K, Okada S, Kinoshita D, Kobayashi Y, Fruttiger M, Aiba A, Minamino T. A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. PLoS One 2014; 9: e102186. 33. Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A,Yamashita M, Kobayashi Y, Shimizu I, Minamino T. Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway. PLoS One 2014; 9: e100359. 34. Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H. Tumor suppresser p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 2013; 191: 3614-3623. (IF=4.718, CI=34) 35. Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I. Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cell. Hypertens Res. 2013; 36: 859-865. (IF=3.217, CI=26) 36. Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. Cell Metab. 2013; 18: 491-504. (IF=22.415, CI=58) 37. Bezzina CR, Barc J, Mizusawa Y, Ann Remme C, Gourraud J-B, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Salling Olesen M, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden D, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott J-J, Dina C, Redon R. Common variants at the SCN5A/SCN10A and HEY2 loci predispose to Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet. 2013; 45: 1044-1049. (IF=25.455, CI=249) 38. Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Naoaki I, Minamino T. Haploinsufficiency of Akt1 prolongs the lifespan of mice. PLoS One 2013; 8: e69178. (IF=2.776, CI=33) 39. Tomita K, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi Tp53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice. J Hepatol. 2012; 57: 837-843. 40. Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I. Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway. Arterioscler Thromb Vasc Biol. 2012; 32: 1902-1909. (IF=6.618, CI=66) 41. Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. Complement C1q activates canonical Wnt signaling and promotes age-related phenotypes. Cell 2012; 149: 1298-1313. (IF=36.216, CI=134) 42. Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice. Hypertension 2012; 59: 627-633. (IF=7.017, CI=27) 43. Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab. 2012; 15: 51-64. (IF=22.415, CI=94) 44. Nakano D, Lei B, Kitada K, Hitomi H, Kobori H, Mori H, Deguchi K, Masaki T, Minamino T, Nishiyama A. Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice. Am J Hypertens. 2012; 25: 354-358. (IF=2.530, CI=3) 45. Odaka K, Aoki I, Moriya J, Tateno K, Tadokoro H, Kershaw J, Minamino T, Irie T, Fukumura T, Komuro I, and Saga T. In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging. PLoS One 2011; 6: e25487. (IF=2.776, CI=5) 46. Wu X, Zou Y, Zhou Q, Huang L, Gong H, Sun A, Tateno K, Katsube K, Radtke F, Ge J, Minamino T, Komuro I. Role of JAGGED1 in arterial lesions after vascular injury. Arterioscler Thromb Vasc Biol. 2011; 31: 2000-2006. (IF=6.618, CI=23) 47. Toko H, Takahashi H, Kayama Y, Oka T, Minamino T, Okada S, Morimoto S, Zhan DY, Terasaki F, Anderson ME, Inoue M, Yao A, Nagai R, Kitaura Y, Sasaguri T, Komuro I. Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation 2010; 122: 891-899. (IF=23.054, CI=64) 48. Toko H, Takahashi H, Kayama Y, Okada S, Minamino T, Terasaki F, Kitaura Y, and Komuro I. ATF6 is important under both pathological and physiological states in the heart. J Mol Cell Cardiol. 2010; 49:113-20. (IF=5.055, CI=48) 49. Naito AT, Okada S, Minamino T, Iwanaga K, Liu M, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I. Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res. 2010; 106 :1692-1702. (IF=15.862, CI=85) 50. Shimizu I, Minamino T*, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED and Komuro I. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload. J Clin Invest. 2010; 120 :1506-1514. (Co-first author) (IF=12.282, CI=109) 51. Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I. Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis. Circ Res. 2010; 106: 391-398. (Co-first author) (IF=15.862, CI=44) 52. Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009; 15: 1082-1087. (IF=30.641, CI=393) 53. Kayama Y, Minamino T*, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H and Komuro I. Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure. J Exp Med. 2009; 206: 1565-1574. (Co-first author) (IF=10.892, CI=71) 54. Moriya J, Minamino T, Tateno K, Shimizu N, Kuwabara Y, Sato Y, Saito Y and Komuro I. Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia. Circ Cardiovasc Intervent. 2009; 2: 245-254. (Co-first author) (IF=6.088, CI=62) 55. Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, Moriya J, Komuro I. Protective role of SIRT1 in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol. 2009; 29: 889-894. (Co-first author) (IF=6.618, CI=142) 56. Nishi J, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I. Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res 2008; 103: 261-268. (*Co-first author) (IF=15.862, CI=40) 57. Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M and Komuro I. IGFBP-4 is an inhibitor of canonical Wnt signaling required for cardiogenesis. Nature 2008; 454:345-349. (IF= 43.070, CI=158) 58. Kunieda T, Minamino T*, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res. 2008; 102: 607-614. (Co-first author) (IF=15.862, CI=72) 59. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin J D, Zou Y and Komuro I. p53-induced Inhibition of hif-1 causes cardiac dysfunction during pressure overload. Nature 2007; 446: 444-448. (Co-first author) (IF=43.070, CI=587) 60. Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M, Takaki E, Aoyagi T, Tojo K, Tajima N, Nakai A, Aburatani H, Komuro I. Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy. Circ Res. 2006; 99: 1411-1418. (IF=15.862, CI=70) 61. Kunieda T, Minamino T*, Nishi J, Tateno K, Oyama T, Katsuno T, Miyauchi H, Orimo M, Okada S, Takamura M, Nagai T, Kaneko S and Komuro I. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006; 114: 953-960. (Co-first author) 62. Tateno K, Minamino T, Toko H, Akazawa H, Shimizu N, Takeda S, Kunieda T, Miyauchi H, Oyama T, Matsuura K, Nishi JI, Kobayashi Y, Nagai T, Kuwabara Y, Iwakura Y, Nomura F, Saito Y, Komuro I. Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. Circ Res. 2006; 98: 1194-1202. (Co-first author) 63. Kunieda T, Minamino T, Katsuno T, Tateno K, Nishi JI, Miyauchi H, Orimo M, Okada S, Komuro I. Cellular senescence impairs circadian expression of clock genes in vitro and in vivo. Circ Res. 2006; 98: 532-539. 64. Naito AT, Akazawa H, Takano H, Minamino T, Nagai T, Aburatani H, Komuro I. Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling. Circ Res. 2005; 22: 144-151. 65. Harada M, Qin Y, Takano H, Minamino T, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi J, Iwanaga K, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I. G-CSF prevents cardiac remodeling after myocardial infarction by activating Jak/Stat in cardiomyocytes. Nat Med. 2005; 11: 305-311. (*Co-first author) 66. Matsuura K, Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I. Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. J Cell Biol. 2004; 167: 351-363. 67. Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol. 2004; 6: 499-506. 68. Toko H, Zou Y, Minamino T, Sakamoto M, Sano M, Harada M, Nagai T, Sugaya T, Terasaki F, Kitaura Y, Komuro I. Angiotensin II type 1a receptor is involved in cell infiltration, cytokine production, and neovascularization in infarcted myocardium. Arterioscler Thromb Vasc Biol. 2004; 24: 664-670. 69. Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 2004; 23 212–220. (Co-first author) 70. Zou Y, Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I. Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation 2003; 108: 3024-3030. 71. Minamino T, Yoshida T, Tateno K, Miyauchi H, Zou Y, Toko H, Komuro I. Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation 2003; 108: 2264-2269. 72. Zou Y, Takano H, Mizukami M, Akazawa H, Qin Y, Toko H, Sakamoto M, Minamino T, Nagai T, Komuro I. Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction. Circulation 2003; 108: 748-753. (IF=23.054, CI=76) 73. Zampetaki A, Minamino T, Mitsialis SA, Kourembanas S. Effect of heme oxygenase-1 overexpression in two models of lung inflammation. Exp Biol Med. 2003; 228: 442-446. (IF=3.005, CI=53) 74. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis. J Cardiol. 2003; 41: 39-40. 75. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis. Role of telomere in endothelial dysfunction. Circulation. 2002; 105: 1541-1544. 76. Minamino T, Toko H, Tateno K, Nagai T, Komuro I. Peripheral-blood or bone-marrow mononuclear cells for therapeutic angiogenesis? Lancet 2002; 360:2083-2084. (IF=59.102, CI=62) 77. Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA and Kourembanas S. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci USA. 2001; 98:8798-8803. (IF=9.580, CI=303) 78. Minamino T and Kourembanas S. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res. 2001; 89:237-243. 79. Minamino T, Mitsialis SA and Kourembanas S. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol 2001; 21:3336-3342. 80. Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S and Yazaki Y. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase as a risk factor for coronary artery disease. Circulation 1997; 95:2032-2036. (IF=23.054, CI=301) 81. Minamino T, Kurihara H, Takahashi M, Shimada K, Maemura K, Oda H, Ishikawa T, Uchiyama T, Tanzawa K and Yazaki Y. Endothelin converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis. Circulation 1997; 95: 221-230. (IF=23.054, CI=108) Invited Reviews and Editorials: 82. Suda M, Tchkonia T, Kirkland JL, Minamino T. Targeting senescent cells for the treatment of age-associated diseases. J Biochem. 2025. doi: 10.1093/jb/mvae091 83. Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M. Guidelines for minimal information on cellular senescence experimentation in vivo. Cell. 2024 Aug 8;187(16):4150-4175. doi: 10.1016/j.cell.2024.05.059. 84. Suda M, Paul KH, Tripathi U, Minamino T, Tchkonia T, Kirkland JL. Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction. Endocr Rev. 2024; 45: 655–675. doi: 10.1210/endrev/bnae010 85. Suda M, Paul KH, Minamino T, Miller JD, Lerman A, Ellison-Hughes GM, Tchkonia T, Kirkland JL. Senescent Cells: A Therapeutic Target in Cardiovascular Diseases. Cells. 2023 May 2;12(9):1296. doi: 10.3390/cells12091296. 86. Chikata Y, Iwata H, Minamino T. The Prognostic Efficacy of DPP-4 Inhibitors in Asian HFpEF: Do They Still Have a Chance? JACC Asia. 2023 Jan 3;3(1):105-107. doi: 10.1016/j.jacasi.2022.11.008. eCollection 2023 Feb. 87. Iwata H, Minamino T. Identification of a novel therapeutic target in vascular dysfunction: A showcase of reverse and forward translational research linking between bench and bedside. Eur Heart J. 2022; 43(6): 501-503. doi: 10.1093/eurheartj/ehab263. 88. Katsuumi G, Shimizu I, Yoshida Y, Minamino T. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med. 2018; 5: 18. doi: 10.3389/fcvm.2018.00018. (CI=25) 89. Moriya J, Minamino T. Angiogenesis, cancer, and vascular aging. Front Cardiovasc Med. 2017; 4: 65. (CI=11) 90. Shimizu I, Minamino T. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016; 97: 245-262. (IF=5.055, CI=198) 91. Watanabe H, Minamino T. Genetics of Brugada syndrome. J Hum Genet. 2016; 61: 57-60. (IF=3.545, CI=31) 92. Shimizu I, Yoshida Y, Minamino T. A role for circadian clock in metabolic disease. Hypertens Res. 2016; 39: 483-491. (IF=3.217, CI=17) 93. Shimizu I, Yoshida Y, Minamino T. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity. Diabetes 2015; 64: 3984-3986. (IF=7.199, CI=8) 94. Shimizu I, Yoshida Y, Suda M, Minamino T. DNA damage response and metabolic disease. Cell Metab. 2014; 20: 967-977. (IF=22.415, CI=84) 95. Minamino T and Komuro I. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Rev Cardiol (Nat Clin Pract Cardiovasc Med). 2008; 5: 637-648. (IF= 17.420, CI=74) 96. Toko H, Minamino T, Komuro I. Role of heat shock transcriptional factor 1 and heat shock proteins in cardiac hypertrophy. Trends Cardiovasc Med. 2008; 18: 88-93. (IF=4.462 CI=20) 97. Minamino T and Komuro I. Role of telomeres in vascular senescence. Front Biosci. 2008; 13: 2971-2979. (IF=3.736, CI=30) 98. Minamino T and Komuro I. Vascular cell senescence: Contribution to atherosclerosis. Circ Res. 2007; 100: 15-26. (IF=15.862, CI=374) 99. Minamino T and Komuro I. Critical roles of insulin-induced senescence in diabetic vasculopathy. Vascular Disease Prevention 2007; 4: 194-200. (CI=0) 100. Minamino T, Komuro I. Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. J Clin Invest. 2006; 116: 2316-2319. (IF=12.282, CI=76) 101. Tateno K, Minamino T, Miyauchi H, Kunieda T, Komuro I. Application of hematopoietic cells to therapeutic angiogenesis. Curr Pharm Des. 2006; 12: 557-563. (IF=2.412, CI=8) 102. Minamino T, Miyauchi H, Yoshida T, Tateno K and Komuro I. The role of vascular cell senescence in atherosclerosis. Antisenescence as a novel therapeutic strategy for vascular aging. Curr Vasc Pharmacol. 2004; 2: 141-148. (IF=2.583, CI=39) 103. Minamino T, Miyauchi H, Tateno K, Kunieda T, Komuro I. Akt-induced senescence: Impication for human disease. Cell Cycle 2004; 4: 449-451. (IF=3.259, CI=0) 104. Minamino T, Miyauchi H, Yoshida T, Tateno K, Kunieda T, Komuro I. Vascular cell senescence and vascular aging. J Mol Cell Cardiol. 2004; 36:175-183. (IF=5.055, CI=114) 105. Minamino T and Komuro I. The role of telomerase activation in the regulation of vascular smooth muscle cell proliferation. Drug News Perspect. 2003; 16:211-216. (IF=3.132, CI=9) 106. Minamino T and Komuro I*. Role of telomere in endothelial dysfunction in atherosclerosis. Curr Opin Lipidol. 2002; 13:537-543. (IF=4.844, CI=40) Books: 107. Katsuumi G, Minamino T. Cellular Senescence in Disease. 1st Edition - November 27, 2021. Editors: Manuel Serrano, Daniel Munoz-Espin. eBook ISBN: 9780128225158. Paperback ISBN: 9780128225141. Chapter 9. Vascular diseases. ii. Atherosclerosis and atherosclerotic cardiovascular diseases. 108. Suda M, Shimizu I, Yoshida Y, Katsuumi G, Minamino T. Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease. 1st Edition - April 15, 2022. Editor: Julio Chirinos. Hardcover ISBN: 9780323913911. Endothelial cell dysfunction and Senescence: Biologic mechanisms and Hemodynamic consequences. 109. Suda M, Shimizu I, Yoshida Y, Minamino T. Chapter 2. Peripheral Blood Mononuclear Cells for Limb Ischemia. 2017: 25–43. (Springer publication). 110. Yoshida Y, Shimizu I, Minamino T. Diabetes and adipocyte dysfunction. Diabetes and Aging-related Complications. 2017: 69-84. (Springer publication). 111. Minamino T, Komuro I. Vascular cell senescence in human atherosclerosis. In: Atherosclerosis XIII (edited by Yuji Matsuzawa, Toru Kita, Ryozo Nagai, and Tamio Teramoto), p566-569, ELSEVIER, Netherlands, 2004.

研究テーマ

循環器内科学

研究業績（論文）

BIBLIOGRAPHY（selected)
Original articles:
1. Katsuumi G, Shimizu I, Suda M, Yoshida Y, Furihata T, Joki Y, Hsiao CL, Jiaqi L, Fujiki S, Abe M, Sugimoto M, Soga T, Minamino T. SGLT2 inhibition eliminates senescent cells and alleviates pathological aging. Nat Aging. 2024 Jul;4(7):926-938. doi: 10.1038/s43587-024-00642-y.
2. Hsiao YT, Yoshida Y, Okuda S, Abe M, Mizuno S, Takahashi S, Nakagami H, Morishita R, Kamimura K, Terai S, Aung TM, Li J, Furihata T, Tang JY, Walsh K, Ishigami A, Minamino T, Shimizu I. PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis. EMBO J. 2024 Nov;43(21):4846-4869. doi: 10.1038/s44318-024-00196-0.
3. Inoue S, Ko T, Shindo A, Nomura S, Yamada T, Jimba T, Dai Z, Nakao H, Suzuki A, Kashimura T, Iwahana T, Goto K, Matsushima S, Ishida J, Amiya E, Zhang B, Kubota M, Sawami K, Heryed T, Yamada S, Katoh M, Katagiri M, Ito M, Nayakama Y, Fujiu K, Hatano M, Takeda N, Takimoto E, Akazawa H, Morita H, Yamaguchi J, Inomata T, Kobayashi Y, Minamino T, Tsutsui H, Kurokawa M, Aiba A, Aburatani H, Komuro I. Association Between Clonal Hematopoiesis and Left Ventricular Reverse Remodeling in Nonischemic Dilated Cardiomyopathy. JACC Basic Transl Sci. 2024 Jun 12;9(8):956-967. doi: 10.1016/j.jacbts.2024.04.010.
4. Tanaka A, Kida K, Matsue Y, Imai T, Suwa S, Taguchi I, Hisauchi I, Teragawa H, Yazaki Y, Moroi M, Ohashi K, Nagatomo D, Kubota T, Ijichi T, Ikari Y, Yonezu K, Takahashi N, Toyoda S, Toshida T, Suzuki H, Minamino T, Nogi K, Shiina K, Horiuchi Y, Tanabe K, Hachinohe D, Kiuchi S, Kusunose K, Shimabukuro M, Node K. In-hospital initiation of angiotensin receptor-neprilysin inhibition in acute heart failure: the PREMIER trial. Eur Heart J. 2024 Nov 8;45(42):4482-4493. doi: 10.1093/eurheartj/ehae561.
5. Fontana M, Berk JL, Gillmore JD, Witteles RM, Grogan M, Drachman B, Damy T, Garcia-Pavia P, Taubel J, Solomon SD, Sheikh FH, Tahara N, González-Costello J, Tsujita K, Morbach C, Pozsonyi Z, Petrie MC, Delgado D, Van der Meer P, Jabbour A, Bondue A, Kim D, Azevedo O, Hvitfeldt Poulsen S, Yilmaz A, Jankowska EA, Algalarrondo V, Slugg A, Garg PP, Boyle KL, Yureneva E, Silliman N, Yang L, Chen J, Eraly SA, Vest J, Maurer MS; HELIOS-B Trial Investigators. Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy. N Engl J Med. 2024 Aug 30. doi: 10.1056/NEJMoa2409134.
6. Fujiki S, Iijima K, Nakagawa Y, Takahashi K, Okabe M, Kusano K, Owada S, Kondo Y, Tsujita K, Shimizu W, Tomita H, Watanabe M, Shoda M, Watanabe M, Tokano T, Murohara T, Kaneshiro T, Kato T, Hayashi H, Maemura K, Niwano S, Umemoto T, Yoshida H, Ota K, Tanaka T, Kitamura N, Node K, Minamino T; EMPA ICD investigators. Effect of empagliflozin on ventricular arrhythmias in patients with type 2 diabetes treated with an implantable cardioverter-defibrillator: the EMPA-ICD trial. Cardiovasc Diabetol. 2024 Jun 28;23(1):224. doi: 10.1186/s12933-024-02309-9.
7. Furuuchi R, Shimizu I, Yoshida Y, Katsuumi G, Suda M, Kubota Y, Walsh K, Minamino T. Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue. iScience. 2022 Oct 20;25(11):105424. doi: 10.1016/j.isci.2022.105424.
8. Yoshida Y, Shimizu I, Shimada A, Nakahara K, Yanagisawa S, Kubo M, Fukuda S, Ishii C, Yamamoto H, Ishikawa T, Kano K, Aoki J, Katsuumi G, Suda M, Ozaki K, Yoshida Y, Okuda S, Ohta S, Okamoto S, Minokoshi Y, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T, Minamino T. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Sci Rep. 2022 Sep 1;12(1):14883. doi: 10.1038/s41598-022-19245-x.
9. Hayashi Y, Shimizu I, Yoshida Y, Ikegami R, Suda M, Katsuumi G, Fujiki S, Ozaki K, Abe M, Sakimura K, Okuda S, Hayano T, Nakamura K, Walsh K, Jespersen N, Nielsen S, Scheele C, Minamino T. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity. iScience 2022; 25(7): 104547. doi: 10.1016/j.isci.2022.104547.
10. Yoshida Y, Shimizu I, Hsiao Y-H, Suda M, Katsuumi G, Seki M, Suzuki Y, Okuda S, Soga T, and Minamino T. Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue. iScience 2022; 25(5): 104268. doi: 10.1016/j.isci.2022.104268.
11. Park N, Marquez J, Pham TK, Ko TH, Youm JB, Kim M, Choi SH, Moon J, Flores J, Ko KS, Rhee BD, Shimizu I, Minamino T, Du Ha J, Hwang JY, Yang SJ, Park CS, Kim HK, Han J. Cereblon contributes to cardiac dysfunction by degrading Cav1.2α. Eur Heart J. 2022 May 21;43(20):1973-1989. doi: 10.1093/eurheartj/ehac072.
12. Suda M, Shimizu I, Katsuumi G, Yoshida Y, Matsumoto N, Hayashi Y, Ikegami R, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Nakanishi-Matsui M, Minamino T. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging. 2021; 1: 1117–1126. doi:10.1038/s43587-021-00151-2.
13. Nakao M, Shimizu I, Katsuumi G, Yoshida Y, Suda M, Hayashi Y, Ikegami R, Hsiao YT, Okuda S, Soga T, Minamino T. Empagliflozin maintains capillarization and improves cardiac function in a murine model of left ventricular pressure overload. Sci Rep. 2021; 11(1): 18384. doi: 10.1038/s41598-021-97787-2.
14. Hsiao YT, Shimizu I, Wakasugi T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Izumi D, Kashimura T, Ozaki K, Soga T, Minamino T. Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy. Sci Rep. 2021; 11(1): 6722. doi: 10.1038/s41598-021-86209-y.
15. Fujiki S, Iijima K, Okabe M, Niwano S, Tsujita K, Naito S, Ando K, Kusano K, Kato R, Nitta J, Miura T, Mitsuhashi T, Kario K, Kondo Y, Ieda M, Hagiwara N, Murohara T, Takahashi K, Tomita H, Takeishi Y, Anzai T, Shimizu W, Watanabe M, Morino Y, Kato T, Tada H, Nakagawa Y, Yano M, Maemura K, Kimura T, Yoshida H, Ota K, Tanaka T, Kitamura N, Node K, Aizawa Y, Shimizu I, Izumi D, Ozaki K, Minamino T; EMPA-ICD investigators. Placebo-Controlled, Double-Blind Study of Empagliflozin (EMPA) and Implantable Cardioverter-Defibrillator (EMPA-ICD) in Patients with Type 2 Diabetes (T2DM): Rationale and Design. Diabetes Ther. 2020; 11(11): 2739-2755.
16. Nakatsu Y, Matsunaga Y, Yamamotoya T, Ueda K, Inoue MK, Mizuno Y, Nakanishi M, Sano T, Yamawaki Y, Kushiyama A, Sakoda H, Fujishiro M, Ryo A, Ono H, Minamino T, Takahashi SI, Ohno H, Yoneda M, Takahashi K, Ishihara H, Katagiri H, Nishimura F, Kanematsu T, Yamada T, Asano T*. Prolyl isomerase Pin1 suppresses thermogenic programs in adipocytes by promoting degradation of transcriptional co-activator PRDM16. Cell Rep. 2019; 26: 3221-3230.
17. Yokoyama M, Shimizu I, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T*. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol. 2019; 129: 105-117.
18. Wakasugi T, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Nakao M, Hoyano M, Kashimura T, Nakamura K, Ito H, Nojiri T, Soga T, Minamino T*. Role of smooth muscle cell p53 in pulmonary arterial hypertension. PLoS One. 2019; 14: e0212889.
19. Yoshida Y, Shimizu I, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagami H, Morishita R, Minamino T*. Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity. Sci Rep. 2019; 9: 3858.
20. Ikegami R, Shimizu I, Sato T, Yoshida Y, Hayashi Y, Suda Ma, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Zenius Jespersen N, Scheele C, Soga T, Minamino T*. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic derangement in obesity. Cell Rep. 2018: 24: 2827-2837.
21. Teratani T, Tomita K*, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S, Minamino T, Oike Y, Hokari R, and Kanai T. Aortic carboxypeptidase–like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis. J Clin Invest. 2018; 128: 1581-1596.
22. Furuuchi R, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T*. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLoS One. 2018; 13: e0202051.
23. Kayamori H, Shimizu I, Yoshida Y, Hayashi Y, Suda M, Ikegami R, Katsuumi G, Wakasugi T, Minamino T*. Amlodipine inhibits vascular cell senescence and protects against atherogenesis through the mechanism independent of calcium channel blockade. Int Heart J. 2018; 59: 607-613.
24. Katsuumi G, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Wakasugi T, Nakao M, Minamino T*. Catecholamine-induced senescence of endothelial cells and bone marrow cells promotes cardiac dysfunction in mice. Int Heart J. 2018; 59: 837-844.
25. Suda M, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T*. Inhibition of dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. PLoS One. 2017; 12: e0182422.
26. Nishiuchi S, Makiyama T*, Aiba T, Nakajima K, Hirose S, Kohjitani H, Yamamoto Y, Harita T, Hayano M, Wuriyanghai Y, Chen J, Sasaki K, Yagihara N, Ishikawa T, Onoue K, Murakoshi N, Watanabe I, Ohkubo K, Watanabe H, Ohno S, Doi T, Shizuta S, Minamino T, Saito Y, Oginosawa Y, Nogami A, Aonuma K, Kusano K, Makita N, Shimizu W, Horie M, Kimura T. Gene-based risk stratification for cardiac disorders in LMNA mutation carriers. Circ Cardiovasc Genet. 2017; 10. pii: e001603. doi:10.1161/CIRCGENETICS.116.001603.
27. Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AA, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N*. Variants in the SCN5A promoter associated with various arrhythmia phenotypes. J Am Heart Assoc. 2016; 5. doi: 10.1161/JAHA.116.003644.
28. Yoshida Y, Shimizu I, Katsuumi G, Jiao S, Suda M, Hayashi Y, Minamino T*. p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload. J Mol Cell Cardiol. 2015; 85: 183-198.
29. Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I*. Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling. Nat Commun. 2015; 6: 6241.
30. Suzuki H, Kayama Y*, Sakamoto M, Iuchi H, Shimizu I, Yoshino T, Katoh D, Nagoshi T, Tojo K, Minamino T, Yoshimura M, Utsunomiya K. Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of Diabetic Cardiomyopathy. Diabetes 2015; 64: 618-630.
31. Nakagomi A, Okada S, Yokoyama M, Yoshida Y, Shimizu I, Miki T, Kobayashi Y, Minamino T*. Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. NPJ Aging Mech Dis. 2015; 1: 15009.
32. Ito TK, Yokoyama M, Yoshida Y, Nojima A, Kassai H, Oishi K, Okada S, Kinoshita D, Kobayashi Y, Fruttiger M, Aiba A, Minamino T*. A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. PLoS One 2014; 9: e102186.
33. Yoshida Y, Hayashi Y, Suda M, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A,Yamashita M, Kobayashi Y, Shimizu I, Minamino T*. Notch signaling regulates the lifespan of vascular endothelial cells via a p16-dependent pathway. PLoS One 2014; 9: e100359.
34. Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H*. Tumor suppresser p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 2013; 191: 3614-3623. (IF=4.718, CI=34)
35. Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I*. Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cell. Hypertens Res. 2013; 36: 859-865. (IF=3.217, CI=26)
36. Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T*. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. Cell Metab. 2013; 18: 491-504. (IF=22.415, CI=58)
37. Bezzina CR*, Barc J, Mizusawa Y, Ann Remme C, Gourraud J-B, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Salling Olesen M, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden D, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott J-J, Dina C, Redon R. Common variants at the SCN5A/SCN10A and HEY2 loci predispose to Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet. 2013; 45: 1044-1049. (IF=25.455, CI=249)
38. Nojima A, Yamashita M, Yoshida Y, Shimizu I, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Naoaki I, Minamino T*. Haploinsufficiency of Akt1 prolongs the lifespan of mice. PLoS One 2013; 8: e69178. (IF=2.776, CI=33)
39. Tomita K*, Teratani T, Suzuki T, Oshikawa T, Yokoyama H, Shimamura K, Nishiyama K, Mataki N, Irie R, Minamino T, Okada Y, Kurihara C, Ebinuma H, Saito H, Shimizu I, Yoshida Y, Hokari R, Sugiyama K, Hatsuse K, Yamamoto J, Kanai T, Miura S, Hibi Tp53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice. J Hepatol. 2012; 57: 837-843.
40. Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, Katagiri H, Minamino T, Komuro I*. Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway. Arterioscler Thromb Vasc Biol. 2012; 32: 1902-1909. (IF=6.618, CI=66)
41. Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I*. Complement C1q activates canonical Wnt signaling and promotes age-related phenotypes. Cell 2012; 149: 1298-1313. (IF=36.216, CI=134)
42. Yasuda N, Akazawa H, Ito K, Shimizu I, Kudo-Sakamoto Y, Yabumoto C, Yano M, Yamamoto R, Ozasa Y, Minamino T, Naito AT, Oka T, Shiojima I, Tamura K, Umemura S, Nemer M, Komuro I*. Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice. Hypertension 2012; 59: 627-633. (IF=7.017, CI=27)
43. Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T*. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab. 2012; 15: 51-64. (IF=22.415, CI=94)
44. Nakano D*, Lei B, Kitada K, Hitomi H, Kobori H, Mori H, Deguchi K, Masaki T, Minamino T, Nishiyama A. Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice. Am J Hypertens. 2012; 25: 354-358. (IF=2.530, CI=3)
45. Odaka K, Aoki I*, Moriya J, Tateno K, Tadokoro H, Kershaw J, Minamino T, Irie T, Fukumura T, Komuro I, and Saga T. In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging. PLoS One 2011; 6: e25487. (IF=2.776, CI=5)
46. Wu X, Zou Y, Zhou Q, Huang L, Gong H, Sun A, Tateno K, Katsube K, Radtke F, Ge J, Minamino T, Komuro I*. Role of JAGGED1 in arterial lesions after vascular injury. Arterioscler Thromb Vasc Biol. 2011; 31: 2000-2006. (IF=6.618, CI=23)
47. Toko H, Takahashi H, Kayama Y, Oka T, Minamino T, Okada S, Morimoto S, Zhan DY, Terasaki F, Anderson ME, Inoue M, Yao A, Nagai R, Kitaura Y, Sasaguri T, Komuro I*. Ca2+/calmodulin-dependent kinase IIdelta causes heart failure by accumulation of p53 in dilated cardiomyopathy. Circulation 2010; 122: 891-899. (IF=23.054, CI=64)
48. Toko H, Takahashi H, Kayama Y, Okada S, Minamino T, Terasaki F, Kitaura Y, and Komuro I*. ATF6 is important under both pathological and physiological states in the heart. J Mol Cell Cardiol. 2010; 49:113-20. (IF=5.055, CI=48)
49. Naito AT, Okada S, Minamino T, Iwanaga K, Liu M, Sumida T, Nomura S, Sahara N, Mizoroki T, Takashima A, Akazawa H, Nagai T, Shiojima I, Komuro I*. Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury. Circ Res. 2010; 106 :1692-1702. (IF=15.862, CI=85)
50. Shimizu I, Minamino T**, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh GY, Akazawa H, Shiojima I, Kahn CR, Abel ED and Komuro I*. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload. J Clin Invest. 2010; 120 :1506-1514. (**Co-first author) (IF=12.282, CI=109)
51. Moriya J, Minamino T**, Tateno K, Okada S, Uemura A, Shimizu I, Yokoyama M, Nojima A, Okada M, Koga H, Komuro I*. Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis. Circ Res. 2010; 106: 391-398. (**Co-first author) (IF=15.862, CI=44)
52. Minamino T, Orimo M, Shimizu I, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I*. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med. 2009; 15: 1082-1087. (IF=30.641, CI=393)
53. Kayama Y, Minamino T**, Toko H, Sakamoto M, Shimizu I, Takahashi H, Okada S, Tateno K, Moriya J, Yokoyama M, Nojima A, Yoshimura M, Egashira K, Aburatani H and Komuro I*. Cardiac 12/15-lipoxygenase-induced inflammation is involved in heart failure. J Exp Med. 2009; 206: 1565-1574. (**Co-first author) (IF=10.892, CI=71)
54. Moriya J, Minamino T**, Tateno K, Shimizu N, Kuwabara Y, Sato Y, Saito Y and Komuro I*. Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia. Circ Cardiovasc Intervent. 2009; 2: 245-254. (**Co-first author) (IF=6.088, CI=62)
55. Orimo M, Minamino T**, Miyauchi H, Tateno K, Okada S, Moriya J, Komuro I*. Protective role of SIRT1 in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol. 2009; 29: 889-894. (*Co-first author) (IF=6.618, CI=142)
56. Nishi J, Minamino T**, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I*. Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt. Circ Res 2008; 103: 261-268. (**Co-first author) (IF=15.862, CI=40)
57. Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M and Komuro I*. IGFBP-4 is an inhibitor of canonical Wnt signaling required for cardiogenesis. Nature 2008; 454:345-349. (IF= 43.070, CI=158)
58. Kunieda T, Minamino T**, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I*. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circ Res. 2008; 102: 607-614. (**Co-first author) (IF=15.862, CI=72)
59. Sano M, Minamino T**, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin J D, Zou Y and Komuro I*. p53-induced Inhibition of hif-1 causes cardiac dysfunction during pressure overload. Nature 2007; 446: 444-448. (**Co-first author) (IF=43.070, CI=587)
60. Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M, Takaki E, Aoyagi T, Tojo K, Tajima N, Nakai A, Aburatani H, Komuro I*. Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy. Circ Res. 2006; 99: 1411-1418. (IF=15.862, CI=70)
61. Kunieda T, Minamino T**, Nishi J, Tateno K, Oyama T, Katsuno T, Miyauchi H, Orimo M, Okada S, Takamura M, Nagai T, Kaneko S and Komuro I*. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 2006; 114: 953-960. (**Co-first author)
62. Tateno K, Minamino T**, Toko H, Akazawa H, Shimizu N, Takeda S, Kunieda T, Miyauchi H, Oyama T, Matsuura K, Nishi JI, Kobayashi Y, Nagai T, Kuwabara Y, Iwakura Y, Nomura F, Saito Y, Komuro I*. Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization. Circ Res. 2006; 98: 1194-1202. (**Co-first author)
63. Kunieda T, Minamino T, Katsuno T, Tateno K, Nishi JI, Miyauchi H, Orimo M, Okada S, Komuro I*. Cellular senescence impairs circadian expression of clock genes in vitro and in vivo. Circ Res. 2006; 98: 532-539.
64. Naito AT, Akazawa H, Takano H, Minamino T, Nagai T, Aburatani H, Komuro I*. Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling. Circ Res. 2005; 22: 144-151.
65. Harada M, Qin Y, Takano H, Minamino T**, Zou Y, Toko H, Ohtsuka M, Matsuura K, Sano M, Nishi J, Iwanaga K, Akazawa H, Kunieda T, Zhu W, Hasegawa H, Kunisada K, Nagai T, Nakaya H, Yamauchi-Takihara K, Komuro I*. G-CSF prevents cardiac remodeling after myocardial infarction by activating Jak/Stat in cardiomyocytes. Nat Med. 2005; 11: 305-311. (**Co-first author)
66. Matsuura K, Wada H, Nagai T, Iijima Y, Minamino T, Sano M, Akazawa H, Molkentin JD, Kasanuki H, Komuro I*. Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle. J Cell Biol. 2004; 167: 351-363.
67. Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, Komuro I*. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol. 2004; 6: 499-506.
68. Toko H, Zou Y, Minamino T, Sakamoto M, Sano M, Harada M, Nagai T, Sugaya T, Terasaki F, Kitaura Y, Komuro I*. Angiotensin II type 1a receptor is involved in cell infiltration, cytokine production, and neovascularization in infarcted myocardium. Arterioscler Thromb Vasc Biol. 2004; 24: 664-670.
69. Miyauchi H, Minamino T*, Tateno K, Kunieda T, Toko H, Komuro I*. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J. 2004; 23 212–220. (*Co-first author)
70. Zou Y, Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I*. Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation 2003; 108: 3024-3030.
71. Minamino T, Yoshida T, Tateno K, Miyauchi H, Zou Y, Toko H, Komuro I*. Ras induces vascular smooth muscle cell senescence and inflammation in human atherosclerosis. Circulation 2003; 108: 2264-2269.
72. Zou Y, Takano H, Mizukami M, Akazawa H, Qin Y, Toko H, Sakamoto M, Minamino T, Nagai T, Komuro I*. Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction. Circulation 2003; 108: 748-753. (IF=23.054, CI=76)
73. Zampetaki A, Minamino T, Mitsialis SA, Kourembanas S*. Effect of heme oxygenase-1 overexpression in two models of lung inflammation. Exp Biol Med. 2003; 228: 442-446. (IF=3.005, CI=53)
74. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I*. Endothelial cell senescence in human atherosclerosis. J Cardiol. 2003; 41: 39-40.
75. Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I*. Endothelial cell senescence in human atherosclerosis. Role of telomere in endothelial dysfunction. Circulation. 2002; 105: 1541-1544.
76. Minamino T, Toko H, Tateno K, Nagai T, Komuro I*. Peripheral-blood or bone-marrow mononuclear cells for therapeutic angiogenesis? Lancet 2002; 360:2083-2084. (IF=59.102, CI=62)
77. Minamino T, Christou H, Hsieh C-M, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA and Kourembanas S*. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci USA. 2001; 98:8798-8803. (IF=9.580, CI=303)
78. Minamino T and Kourembanas S*. Mechanisms of telomerase induction during vascular smooth muscle cell proliferation. Circ Res. 2001; 89:237-243.
79. Minamino T, Mitsialis SA and Kourembanas S*. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol Cell Biol 2001; 21:3336-3342.
80. Morita H, Taguchi J, Kurihara H*, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S and Yazaki Y. Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase as a risk factor for coronary artery disease. Circulation 1997; 95:2032-2036. (IF=23.054, CI=301)
81. Minamino T, Kurihara H*, Takahashi M, Shimada K, Maemura K, Oda H, Ishikawa T, Uchiyama T, Tanzawa K and Yazaki Y. Endothelin converting enzyme expression in the rat vascular injury model and human coronary atherosclerosis. Circulation 1997; 95: 221-230. (IF=23.054, CI=108)
Invited Reviews and Editorials:
82. Suda M, Tchkonia T, Kirkland JL, Minamino T. Targeting senescent cells for the treatment of age-associated diseases. J Biochem. 2025. doi: 10.1093/jb/mvae091
83. Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M. Guidelines for minimal information on cellular senescence experimentation in vivo. Cell. 2024 Aug 8;187(16):4150-4175. doi: 10.1016/j.cell.2024.05.059.
84. Suda M, Paul KH, Tripathi U, Minamino T, Tchkonia T, Kirkland JL. Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction. Endocr Rev. 2024; 45: 655–675. doi: 10.1210/endrev/bnae010
85. Suda M, Paul KH, Minamino T, Miller JD, Lerman A, Ellison-Hughes GM, Tchkonia T, Kirkland JL. Senescent Cells: A Therapeutic Target in Cardiovascular Diseases. Cells. 2023 May 2;12(9):1296. doi: 10.3390/cells12091296.
86. Chikata Y, Iwata H, Minamino T. The Prognostic Efficacy of DPP-4 Inhibitors in Asian HFpEF: Do They Still Have a Chance? JACC Asia. 2023 Jan 3;3(1):105-107. doi: 10.1016/j.jacasi.2022.11.008. eCollection 2023 Feb.
87. Iwata H, Minamino T. Identification of a novel therapeutic target in vascular dysfunction: A showcase of reverse and forward translational research linking between bench and bedside. Eur Heart J. 2022; 43(6): 501-503. doi: 10.1093/eurheartj/ehab263.
88. Katsuumi G, Shimizu I, Yoshida Y, Minamino T*. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med. 2018; 5: 18. doi: 10.3389/fcvm.2018.00018. (CI=25)
89. Moriya J, Minamino T*. Angiogenesis, cancer, and vascular aging. Front Cardiovasc Med. 2017; 4: 65. (CI=11)
90. Shimizu I, Minamino T*. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016; 97: 245-262. (IF=5.055, CI=198)
91. Watanabe H*, Minamino T. Genetics of Brugada syndrome. J Hum Genet. 2016; 61: 57-60. (IF=3.545, CI=31)
92. Shimizu I, Yoshida Y, Minamino T*. A role for circadian clock in metabolic disease. Hypertens Res. 2016; 39: 483-491. (IF=3.217, CI=17)
93. Shimizu I, Yoshida Y, Minamino T*. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity. Diabetes 2015; 64: 3984-3986. (IF=7.199, CI=8)
94. Shimizu I, Yoshida Y, Suda M, Minamino T*. DNA damage response and metabolic disease. Cell Metab. 2014; 20: 967-977. (IF=22.415, CI=84)
95. Minamino T and Komuro I*. Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes. Nat Rev Cardiol (Nat Clin Pract Cardiovasc Med). 2008; 5: 637-648. (IF= 17.420, CI=74)
96. Toko H, Minamino T, Komuro I*. Role of heat shock transcriptional factor 1 and heat shock proteins in cardiac hypertrophy. Trends Cardiovasc Med. 2008; 18: 88-93. (IF=4.462 CI=20)
97. Minamino T and Komuro I. Role of telomeres in vascular senescence. Front Biosci. 2008; 13: 2971-2979. (IF=3.736, CI=30)
98. Minamino T and Komuro I*. Vascular cell senescence: Contribution to atherosclerosis. Circ Res. 2007; 100: 15-26. (IF=15.862, CI=374)
99. Minamino T and Komuro I*. Critical roles of insulin-induced senescence in diabetic vasculopathy. Vascular Disease Prevention 2007; 4: 194-200. (CI=0)
100. Minamino T, Komuro I*. Regeneration of the endothelium as a novel therapeutic strategy for acute lung injury. J Clin Invest. 2006; 116: 2316-2319. (IF=12.282, CI=76)
101. Tateno K, Minamino T, Miyauchi H, Kunieda T, Komuro I*. Application of hematopoietic cells to therapeutic angiogenesis. Curr Pharm Des. 2006; 12: 557-563. (IF=2.412, CI=8)
102. Minamino T, Miyauchi H, Yoshida T, Tateno K and Komuro I*. The role of vascular cell senescence in atherosclerosis. Antisenescence as a novel therapeutic strategy for vascular aging. Curr Vasc Pharmacol. 2004; 2: 141-148. (IF=2.583, CI=39)
103. Minamino T, Miyauchi H, Tateno K, Kunieda T, Komuro I*. Akt-induced senescence: Impication for human disease. Cell Cycle 2004; 4: 449-451. (IF=3.259, CI=0)
104. Minamino T, Miyauchi H, Yoshida T, Tateno K, Kunieda T, Komuro I*. Vascular cell senescence and vascular aging. J Mol Cell Cardiol. 2004; 36:175-183. (IF=5.055, CI=114)
105. Minamino T and Komuro I*. The role of telomerase activation in the regulation of vascular smooth muscle cell proliferation. Drug News Perspect. 2003; 16:211-216. (IF=3.132, CI=9)
106. Minamino T and Komuro I*. Role of telomere in endothelial dysfunction in atherosclerosis. Curr Opin Lipidol. 2002; 13:537-543. (IF=4.844, CI=40)
Books:
107. Katsuumi G, Minamino T. Cellular Senescence in Disease. 1st Edition - November 27, 2021. Editors: Manuel Serrano, Daniel Munoz-Espin. eBook ISBN: 9780128225158. Paperback ISBN: 9780128225141. Chapter 9. Vascular diseases. ii. Atherosclerosis and atherosclerotic cardiovascular diseases.
108. Suda M, Shimizu I, Yoshida Y, Katsuumi G, Minamino T. Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease. 1st Edition - April 15, 2022. Editor: Julio Chirinos. Hardcover ISBN: 9780323913911. Endothelial cell dysfunction and Senescence: Biologic mechanisms and Hemodynamic consequences.
109. Suda M, Shimizu I, Yoshida Y, Minamino T. Chapter 2. Peripheral Blood Mononuclear Cells for Limb Ischemia. 2017: 25–43. (Springer publication).
110. Yoshida Y, Shimizu I, Minamino T. Diabetes and adipocyte dysfunction. Diabetes and Aging-related Complications. 2017: 69-84. (Springer publication).
111. Minamino T, Komuro I. Vascular cell senescence in human atherosclerosis. In: Atherosclerosis XIII (edited by Yuji Matsuzawa, Toru Kita, Ryozo Nagai, and Tamio Teramoto), p566-569, ELSEVIER, Netherlands, 2004.

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南野 徹（ミナミノ トオル）

南野徹（ミナミノトオル）