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石原量（イシハラリョウ）

研究テーマ	機能性材料の創製
研究業績（論文）	2013～原著論文 Research Papers (: corresponding author) [1] R. Ishihara, A. Katagiri, T. Nakajima, R. Matsui, K. Hosokawa, M. Maeda, Y. Tomooka, A. Kikuchi, Design of a Sensitive Extracellular Vesicle Detection Method Utilizing a Surface-Functionalized Power-Free Microchip, Membranes, 12 (2022) 679. [2] R. Ishihara, Y. Makino, Y. Yamaguchi, K. Fujimoto, K. Nishio, Pt/WO3 Nanoparticle-Dispersed Polydimethylsiloxane Membranes for Transparent and Flexible Hydrogen Gas Leakage Sensors, Membranes, 12 (2022) 291. [3] R. Ishihara, R. Kitane, Y. Akiyama, S. Inomata, K. Hosokawa, M. Maeda, A. Kikuchi, Multiplex MicroRNA Detection on a Surface-Functionalized Power-Free Microfluidic Chip, Anal. Sci., 37 (2021) 747-751. [4] R. Ishihara, K. Tanabe, S. Inomata, R. Matsui, R. Kitane, K. Hosokawa, M. Maeda, A. Kikuchi, Fabrication of Storable Surface-Functionalized Power-Free Microfluidic Chip for Sensitive MicroRNA Detection Utilizing UV Grafting, Ind. Eng. Chem. Res. 59(22) (2020) 10464-10468. [5] S. Komatsu, T. Asoh, R. Ishihara, A. Kikuchi, Fabrication of thermoresponsive degradable hydrogel made by radical polymerization of 2-methylene-1,3-dioxepane: Unique thermal coacervation in hydrogel, Polymer, 179 (2019) 121633. [6] R. Ishihara, A. Katagiri, T. Nakajima, R. Matsui, S. Komatsu, K. Hosokawa, M. Maeda, Y. Tomooka, A. Kikuchi, Design of a Surface-Functionalized Power-Free Microchip for Extracellular Vesicle Detection Utilizing UV grafting, React. Funct. Polym., 142 (2019) 183-188. [7] R. Ishihara,Y. Yamaguchi, K. Tanabe, Y. Makino, K. Nishio, Preparation of Pt/WO3-Coated Polydimethlsiloxane Membrane for Transparent/Flexible Hydrogen Gas Sensors, Materials Chemistry and Physics, 226 (2019) 226-229. [8] S. Komatsu, H. Kayano, Y. Ando, T. Asoh, R. Ishihara, A. Kikuchi, Preparation of Thermo- and Redox-Responsive Branched Polymers Composed of Three-Armed Oligo(ethylene glycol), J. Polym. Sci. A, 56 (2018) 2623-2629. [9] 石原量，放射線グラフト重合法を利用した標的物質捕捉のための材料設計，高分子論文集高分子学会高分子科学・工学のニューウェーブ, 75(5)(2018) 456-467. [10] S. Komatsu, Y. Ikedo, T. Asoh, R. Ishihara, A. Kikuchi, Fabrication of Hybrid Capsules via CaCO3 Crystalization on Degradable Coacervate Droplets, Langmuir, 34(13) (2018) 3981-3986. [11] S. Asai, Y. Hanzawa, M. Konda, D. Suzuki, M. Magara, T. Kimura, R. Ishihara, K. Saito, S. Yamada, H. Hirota, Rapid separation of zirconium using microvolume anion-exchange cartridge for 93Zr determination with isotope dilution ICP-MS, Talanta, 185 (2018) 98-105. [12] S. Uchiyama, T. Sasaki, R. Ishihara, K. Fujiwara, T. Sugo, D. Umeno, K. Saito, High-resolution separation of neodymium and dysprosium ions utilizeing extractant-impregnated graft-type particles, J. Chromatogr. A, 1533 (2018) 10-16. [13] R. Ishihara, T. Nakajima, Y. Uchino, A. Katagiri, K. Hosokawa, M. Maeda, Y. Tomooka, A. Kikuchi, Rapid and Easy Extracellular Vesicle Detection on a Surface-Functionalized Power-Free Microchip toward Point-of-Care Diagnostics, ACS Omega, 2 (2017) 6703-6707. [14] S. Komatsu, T. Asoh, R. Ishihara, A. Kikuchi, Facile Preparation of Degradable Thermoresponsive Polymers as Biomaterials: Thermoresponsive Polymers Prepared by Radical Polymerization Degrade to Water-soluble Oligomers, Polymer, 130 (2017) 68-73. [15] R. Ishihara, Y. Uchino, K. Hosokawa, M. Maeda, A. Kikuchi, Preparation of a Surface-Functionalized Power-Free Microchip for MicroRNA Detection Utilizing Electron Beam-Induced Graft Polymerization, Anal. Sci., 33(2) (2017) 197-202. [16] S. Asai, Y. Hanzawa, M. Konda, D. Suzuki, M. Magara, T. Kimura, R. Ishihara, K. Saito, S. Yamada, H. Hirota, Preparation of Micro-volume Anion-exchange Cartridge for ICP-MS-based Determination of 237Np Content in Spent Nuclear Fuel, Anal. Chem., 88(6) (2016) 3149-3155. [17] R. Ishihara, K. Hasegawa, K. Hosokawa, M. Maeda, Multiplex MicroRNA Detection on a Power-Free Microfluidic Chip with Laminar Flow-Assisted Dendritic Amplification，Anal. Sci., 31(7) (2015) 573-576. [18] 石原量，長谷川和貴，細川和生，前田瑞夫，自律駆動マイクロ流体チップと層流樹状増幅法によるタンパク質と核酸の検出，分析化学，64 (2015) 319-328. [19] Y. Okamura, K. Fujiwara, R. Ishihara, T. Sugo, T. Kojima, D. Umeno, K. Saito, Cesium Removal in Freshwater Using Potassium Cobalt Hexacyanoferrate-Impregnated Fibers, Radiat. Physic. Chem., 94 (2014) 119-122. [20] R. Tanaka, R. Ishihara, K. Miyoshi, D. Umeno, K. Saito, S. Asai, S. Yamada, H. Hirota, Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions, Sep. Sci. Technol., 49(1) (2014) 154-159. [21] R. Ishihara, S. Uchiyama, H. Ikezawa, S. Yamada, H. Hirota, D. Umeno, K. Saito, Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization, Ind. Eng. Chem. Res., 52(35) (2013) 12582-12586. [22] S. Uchiyama, R. Ishihara, D. Umeno, K. Saito, S. Yamada, H. Hirota, S. Asai, Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet, J. Chem. Eng. Japan, 46(6) (2013) 414-419. [23] 岡村雄介，藤原邦夫，飯島直樹，正田哲也，鈴木晃一，須郷高信，清水威，板垣龍人，高橋淳，小野孝之，菊池隆，染谷孝明，石原量，小島隆，梅野太輔，斎藤恭一, 海水中のセシウム除去のための吸着繊維の作製, 日本イオン交換学会誌, 24(1) (2013) 8-13. [24] G. Wada, R. Ishihara, K. Miyoshi, D. Umeno, K. Saito, S. Yamada, H. Hirota, Crosslinked-Chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions, Solv. Extr. Ion Exch., 31(2) (2013) 210-220. 総説 Research Reviews [1] 石原量，マイクロチップによる細胞外ベシクルの分析，化学とマイクロ・ナノシステムトピックス，19(2) (2020) 52-53.(査読あり) [2] R. Ishihara, S. Asai, K. Saito, Recent Progress in Charged Polymer Chanins Grafted by Radiation-Induced Graft Polymerization; Adsorption of Proteins and Immobilization of Inorganic Precipitates, Quantum Beam Science, 4(2) (2020) 20. (doi: 10.3390/qubs4020020, ISSN: 2412-382X)(査読あり) [3] 石原量，猪股祥子，菊池明彦，ポリジメチルシロキサンの気体溶解性を利用した自律駆動型マイクロ流体チップ，ぶんせき，1 (2018) 21-27. (査読あり) [4] 石原量*，猪股祥子，菊池明彦，その場検査のための表面機能化自律駆動マイクロチップによるバイオマーカーの検出，Colloid & Interface Communication，42(3) (2017) 30-33. (査読なし) [5] ✽石原量，色を利用したセルフリー核酸の検出，Journal of the Japan Society of Colour Material, 97(11) (2024) 1-4. (査読あり) [6] ✽石原量，中島忠章，志村絵理，馬場猛，細胞外ベシクル分析の混乱と可能性，分析化学総説，74(4,5), 167-176 (2025). 著書 Books [1] 石原量，中島忠章 (他31名) (分担執筆)，「早期発見・予防に向けた次世代がん検査技術の最前線」，シーエムシー出版，第4編デバイス開発および臨床研究，17章がん診断のための細胞外ベシクル捕捉・破砕用マイクロチップの開発，pp. 156-166 (全216ページ)，2019年2月. (ISBN 978-4-7813-1405-1) 科学雑誌 Scientific Journals [1] R. Ishihara and T. Nakajima, Microchip Development for Extracellular Vesicle Capture and Disruption for Cancer Diagnosis, Impact, Volume 2019, Number 3, pp. 54-55. (ISSN 2398-7073) https://www.ingentaconnect.com/content/sil/impact/2019/00002019/00000003/art00021 DOI: https://doi.org/10.21820/23987073.2019.3.54 エッセイ Essay [1] 石原量, 『教養』を教える？, ぶんせきリレーエッセイ, 8 (2024) 302.

研究テーマ

機能性材料の創製

研究業績（論文）

2013～

原著論文 Research Papers (*: corresponding author)

[1] R. Ishihara*, A. Katagiri, T. Nakajima, R. Matsui, K. Hosokawa, M. Maeda, Y. Tomooka, A. Kikuchi, Design of a Sensitive Extracellular Vesicle Detection Method Utilizing a Surface-Functionalized Power-Free Microchip, Membranes, 12 (2022) 679.
[2] R. Ishihara, Y. Makino, Y. Yamaguchi, K. Fujimoto, K. Nishio, Pt/WO3 Nanoparticle-Dispersed Polydimethylsiloxane Membranes for Transparent and Flexible Hydrogen Gas Leakage Sensors, Membranes, 12 (2022) 291.
[3] R. Ishihara*, R. Kitane, Y. Akiyama, S. Inomata, K. Hosokawa, M. Maeda, A. Kikuchi, Multiplex MicroRNA Detection on a Surface-Functionalized Power-Free Microfluidic Chip, Anal. Sci., 37 (2021) 747-751.
[4] R. Ishihara*, K. Tanabe, S. Inomata, R. Matsui, R. Kitane, K. Hosokawa, M. Maeda, A. Kikuchi, Fabrication of Storable Surface-Functionalized Power-Free Microfluidic Chip for Sensitive MicroRNA Detection Utilizing UV Grafting, Ind. Eng. Chem. Res. 59(22) (2020) 10464-10468.
[5] S. Komatsu, T. Asoh, R. Ishihara, A. Kikuchi, Fabrication of thermoresponsive degradable hydrogel made by radical polymerization of 2-methylene-1,3-dioxepane: Unique thermal coacervation in hydrogel, Polymer, 179 (2019) 121633.
[6] R. Ishihara*, A. Katagiri, T. Nakajima, R. Matsui, S. Komatsu, K. Hosokawa, M. Maeda, Y. Tomooka, A. Kikuchi, Design of a Surface-Functionalized Power-Free Microchip for Extracellular Vesicle Detection Utilizing UV grafting, React. Funct. Polym., 142 (2019) 183-188.
[7] R. Ishihara*,Y. Yamaguchi, K. Tanabe, Y. Makino, K. Nishio, Preparation of Pt/WO3-Coated Polydimethlsiloxane Membrane for Transparent/Flexible Hydrogen Gas Sensors, Materials Chemistry and Physics, 226 (2019) 226-229.
[8] S. Komatsu, H. Kayano, Y. Ando, T. Asoh, R. Ishihara, A. Kikuchi, Preparation of Thermo- and Redox-Responsive Branched Polymers Composed of Three-Armed Oligo(ethylene glycol), J. Polym. Sci. A, 56 (2018) 2623-2629.
[9] 石原量*，放射線グラフト重合法を利用した標的物質捕捉のための材料設計，高分子論文集高分子学会高分子科学・工学のニューウェーブ, 75(5)(2018) 456-467.
[10] S. Komatsu, Y. Ikedo, T. Asoh, R. Ishihara, A. Kikuchi, Fabrication of Hybrid Capsules via CaCO3 Crystalization on Degradable Coacervate Droplets, Langmuir, 34(13) (2018) 3981-3986.
[11] S. Asai, Y. Hanzawa, M. Konda, D. Suzuki, M. Magara, T. Kimura, R. Ishihara, K. Saito, S. Yamada, H. Hirota, Rapid separation of zirconium using microvolume anion-exchange cartridge for 93Zr determination with isotope dilution ICP-MS, Talanta, 185 (2018) 98-105.
[12] S. Uchiyama, T. Sasaki, R. Ishihara, K. Fujiwara, T. Sugo, D. Umeno, K. Saito, High-resolution separation of neodymium and dysprosium ions utilizeing extractant-impregnated graft-type particles, J. Chromatogr. A, 1533 (2018) 10-16.
[13] R. Ishihara*, T. Nakajima, Y. Uchino, A. Katagiri, K. Hosokawa, M. Maeda, Y. Tomooka, A. Kikuchi, Rapid and Easy Extracellular Vesicle Detection on a Surface-Functionalized Power-Free Microchip toward Point-of-Care Diagnostics, ACS Omega, 2 (2017) 6703-6707.
[14] S. Komatsu, T. Asoh, R. Ishihara, A. Kikuchi, Facile Preparation of Degradable Thermoresponsive Polymers as Biomaterials: Thermoresponsive Polymers Prepared by Radical Polymerization Degrade to Water-soluble Oligomers, Polymer, 130 (2017) 68-73.
[15] R. Ishihara*, Y. Uchino, K. Hosokawa, M. Maeda, A. Kikuchi, Preparation of a Surface-Functionalized Power-Free Microchip for MicroRNA Detection Utilizing Electron Beam-Induced Graft Polymerization, Anal. Sci., 33(2) (2017) 197-202.
[16] S. Asai, Y. Hanzawa, M. Konda, D. Suzuki, M. Magara, T. Kimura, R. Ishihara, K. Saito, S. Yamada, H. Hirota, Preparation of Micro-volume Anion-exchange Cartridge for ICP-MS-based Determination of 237Np Content in Spent Nuclear Fuel, Anal. Chem., 88(6) (2016) 3149-3155.
[17] R. Ishihara, K. Hasegawa, K. Hosokawa, M. Maeda, Multiplex MicroRNA Detection on a Power-Free Microfluidic Chip with Laminar Flow-Assisted Dendritic Amplification，Anal. Sci., 31(7) (2015) 573-576.
[18] 石原量，長谷川和貴，細川和生，前田瑞夫，自律駆動マイクロ流体チップと層流樹状増幅法によるタンパク質と核酸の検出，分析化学，64 (2015) 319-328.
[19] Y. Okamura, K. Fujiwara, R. Ishihara, T. Sugo, T. Kojima, D. Umeno, K. Saito, Cesium Removal in Freshwater Using Potassium Cobalt Hexacyanoferrate-Impregnated Fibers, Radiat. Physic. Chem., 94 (2014) 119-122.
[20] R. Tanaka, R. Ishihara, K. Miyoshi, D. Umeno, K. Saito, S. Asai, S. Yamada, H. Hirota, Simple Method for High-Density Impregnation of Aliquat 336 onto Porous Sheet and Binding Performance of Resulting Sheet for Palladium Ions, Sep. Sci. Technol., 49(1) (2014) 154-159.
[21] R. Ishihara, S. Uchiyama, H. Ikezawa, S. Yamada, H. Hirota, D. Umeno, K. Saito, Effect of Dose on Mole Percentage of Polymer Brush and Root Grafted onto Porous Polyethylene Sheet by Radiation-Induced Graft Polymerization, Ind. Eng. Chem. Res., 52(35) (2013) 12582-12586.
[22] S. Uchiyama, R. Ishihara, D. Umeno, K. Saito, S. Yamada, H. Hirota, S. Asai, Determination of Mole Percentages of Brush and Root of Polymer Chain Grafted onto Porous Sheet, J. Chem. Eng. Japan, 46(6) (2013) 414-419.
[23] 岡村雄介，藤原邦夫，飯島直樹，正田哲也，鈴木晃一，須郷高信，清水威，板垣龍人，高橋淳，小野孝之，菊池隆，染谷孝明，石原量，小島隆，梅野太輔，斎藤恭一, 海水中のセシウム除去のための吸着繊維の作製, 日本イオン交換学会誌, 24(1) (2013) 8-13.
[24] G. Wada, R. Ishihara, K. Miyoshi, D. Umeno, K. Saito, S. Yamada, H. Hirota, Crosslinked-Chelating Porous Sheet with High Dynamic Binding Capacity of Metal Ions, Solv. Extr. Ion Exch., 31(2) (2013) 210-220.

総説 Research Reviews
[1] 石原量，マイクロチップによる細胞外ベシクルの分析，化学とマイクロ・ナノシステムトピックス，19(2) (2020) 52-53.(査読あり)
[2] R. Ishihara, S. Asai, K. Saito, Recent Progress in Charged Polymer Chanins Grafted by Radiation-Induced Graft Polymerization; Adsorption of Proteins and Immobilization of Inorganic Precipitates, Quantum Beam Science, 4(2) (2020) 20. (doi: 10.3390/qubs4020020, ISSN: 2412-382X)(査読あり)
[3] 石原量*，猪股祥子，菊池明彦，ポリジメチルシロキサンの気体溶解性を利用した自律駆動型マイクロ流体チップ，ぶんせき，1 (2018) 21-27. (査読あり)
[4] 石原量*，猪股祥子，菊池明彦，その場検査のための表面機能化自律駆動マイクロチップによるバイオマーカーの検出，Colloid & Interface Communication，42(3) (2017) 30-33. (査読なし)
[5] ✽石原量，色を利用したセルフリー核酸の検出，Journal of the Japan Society of Colour Material, 97(11) (2024) 1-4. (査読あり)
[6] ✽石原量，中島忠章，志村絵理，馬場猛，細胞外ベシクル分析の混乱と可能性，分析化学総説，74(4,5), 167-176 (2025).

著書 Books

[1] 石原量，中島忠章 (他31名) (分担執筆)，「早期発見・予防に向けた次世代がん検査技術の最前線」，シーエムシー出版，第4編デバイス開発および臨床研究，17章がん診断のための細胞外ベシクル捕捉・破砕用マイクロチップの開発，pp. 156-166 (全216ページ)，2019年2月. (ISBN 978-4-7813-1405-1)

科学雑誌 Scientific Journals

[1] R. Ishihara and T. Nakajima, Microchip Development for Extracellular Vesicle Capture and Disruption for Cancer Diagnosis, Impact, Volume 2019, Number 3, pp. 54-55. (ISSN 2398-7073)
https://www.ingentaconnect.com/content/sil/impact/2019/00002019/00000003/art00021
DOI: https://doi.org/10.21820/23987073.2019.3.54

エッセイ Essay

[1] 石原量, 『教養』を教える？, ぶんせきリレーエッセイ, 8 (2024) 302.

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研究業績詳細

石原 量（イシハラ リョウ）

石原量（イシハラリョウ）