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研究業績詳細

宮本 恵里(ミヤモト エリ)

研究テーマ 運動能力・スポーツ傷害受傷リスクに関連する遺伝要因の解明
研究業績(論文) 【2022年】
Kumagai H, Kaneko T, Shintake Y, Miyamoto-Mikami E, Tomita H, Fukuo M, Kawai W, Harada M, Kikuchi N, Kamiya N, Hirata K, Zempo H, Maeda S, Miyamoto N, Fuku N. Genetic polymorphisms related to muscular strength and flexibility are associated with artistic gymnastic performance in the Japanese population. Eur J Sport Sci [Online ahead of print]

Kumagai H, Miyamoto-Mikami E, Takaragawa M, Kuriki K, Goto C, Shibata K, Yamada N, Hosono A, Fuku M, Suzuki S, Fuku N. Genetic polymorphisms in CYP19A1 and ESR1 are associated with serum CK activity after prolonged running in men. J Appl Physiol (1985), 132(4):966-973, 2022.

【2021年】
Takaragawa M, Tobina T, Shiose K, Kakigi R, Tsuzuki T, Ichinoseki-Sekine N, Kumagai H, Zempo H, Miyamoto-Mikami E, Kobayashi H, Naito H, Fuku N. Genotype Score for Iron Status Is Associated with Muscle Fiber Composition in Women. Genes (Basel), 13(1):5, 2021.

Miyamoto-Mikami E, Kumagai H, Tanisawa K, Taga Y, Hirata K, Kikuchi N, Kamiya N, Kawakami R, Midorikawa T, Kawamura T, Kakigi R, Natsume T, Zempo H, Suzuki K, Kohmura Y, Mizuno K, Torii S, Sakamoto S, Oka K, Higuchi M, Naito H, Miyamoto N, Fuku N. Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury: Potential Role of COL1A1 Variant. Med Sci Sports Exerc, 53(9):1855-1864, 2021.

Alvarez-Romero J, Laguette MJN, Seale K, Jacques M, Voisin S, Haim D, Feller JA, Tirosh O, Miyamoto-Mikami E, Kumagai H, Kikuchi N, Kamiya N, Fuku N, Collins M, September AV, Eynon N. Genetic variants within the COL5A1 gene are associated with ligament injuries in physically active populations from Australia, South Africa, and Japan. Eur J Sport Sci [Online ahead of print]

Kumagai H, Natsume T, Kim SJ, Tobina T, Miyamoto-Mikami E, Shiose K, Ichinoseki-Sekine N, Kakigi R, Tsuzuki T, Miller B, Yen K, Murakami H, Miyachi M, Zempo H, Dobashi S, Machida S, Kobayashi H, Naito H, Cohen P, Fuku N.The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance. Biochim Biophys Acta Gen Subj, 1866(2):130048, 2021.

Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. Aging (Albany NY), 13(2):1692-1717, 2021.

【2020年】
Miyamoto-Mikami E, Kumagai H, Kikuchi N, Kamiya N, Miyamoto N, Fuku N. eQTL variants in COL22A1 are associated with muscle injury in athletes. Physiol Genomics, 52(12):588-589, 2020.

Guilherme JPLF, Semenova EA, Zempo H, Martins GL, Lancha Junior AH, Miyamoto-Mikami E, Kumagai H, Tobina T, Shiose K, Kakigi R, Tsuzuki T, Ichinoseki-Sekine N, Kobayashi H, Naito H, Borisov OV, Kostryukova ES, Kulemin NA, Larin AK, Generozov EV, Fuku N, Ahmetov II. Are Genome-Wide Association Study Identified Single-Nucleotide Polymorphisms Associated With Sprint Athletic Status? A Replication Study With 3 Different Cohorts. Int J Sports Physiol Perform, 15:1-7, 2020.

Kumagai H, Miyamoto-Mikami E, Kikuchi N, Kamiya N, Zempo H, Fuku N. A rs936306 C/T Polymorphism in the CYP19A1 Is Associated With Stress Fractures. J Strength Cond Res, 2020[E-pub].

Yvert T, Miyamoto-Mikami E, Tobina T, Shiose K, Kakigi R, Tsuzuki T, Takaragawa M, Ichinoseki-Sekine N, Pérez M, Kobayashi H, Tanaka H, Naito H, Fuku N. PPARGC1A rs8192678 and NRF1 rs6949152 Polymorphisms Are Associated with Muscle Fiber Composition in Women. Genes, 11(9):E1012, 2020.

Massidda M, Miyamoto-Mikami E, Kumagai H, Ikeda H, Shimasaki Y, Yoshimura M, Cugia P, Piras F, Scorcu M, Kikuchi N, Calò CM, Fuku N. Association between the ACE I/D polymorphism and muscle injuries in Italian and Japanese elite football players. J Sports Sci, 38(21):2423-2429, 2020.

Al-Khelaifi F, Yousri NA, Diboun I, Semenova EA, Kostryukova ES, Kulemin NA, Borisov OV, Andryushchenko LB, Larin AK, Generozov EV, Miyamoto-Mikami E, Murakami H, Zempo H, Miyachi M, Takaragawa M, Kumagai H, Naito H, Fuku N, Abraham D, Hingorani A, Donati F, Botrè F, Georgakopoulos C, Suhre K, Ahmetov II, Albagha O, Elrayess MA. Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism. Front Genet, 16(11):595, 2020.

Semenova E, Miyamoto-Mikami E, Akimov E, et al. The association of HEF gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis. Eur J Appl Physiol, 120(3):665-673, 2020.

【2019年】
Miyamoto-Mikami E, Miyamoto N, Kumagai H, Hirata K, Kikuchi N, Zempo H, Kimura N, Kamiya N, Kanehisa H, Naito H, Fuku N. COL5A1 rs12722 polymorphism is not associated with passive muscle stiffness and sports-related muscle injury in Japanese athletes. BMC Medical Genetics. 20(1):192, 2019.

Kumagai H, Miyamoto-Mikami E, Hirata K, Kikuchi N, Kamiya N, Hoshikawa S, Zempo H, Naito H, Miyamoto N, Fuku N. ESR1 rs2234693 Polymorphism Is Associated with Muscle Injury and Muscle Stiffness. Med Sci Sports Exerc. 51(1):19-26, 2019.

【2018年】
Miyamoto-Mikami E, Tsuji K, Horii N, Hasegawa N, Fujie S, Homma T, Uchida M, Hamaoka T, Kanehisa H, Tabata I, Iemitsu M. Gene expression profile of muscle adaptation to high-intensity intermittent exercise training in young men. Sci Rep. 8(1):16811, 2018.

Miyamoto N, Hirata K, Miyamoto-Mikami E, Yasuda O, Kanehisa H. Associations of passive muscle stiffness, muscle stretch tolerance, and muscle slack angle with range of motion: individual and sex differences. Sci Rep. 8(1):8274, 2018.

Hasegawa N, Fujie S, Horii N, Miyamoto-Mikami E, Tsuji K, Uchida M, Hamaoka T, Tabata I, Iemitsu M. Effects of Different Exercise Modes on Arterial Stiffness and Nitric Oxide Synthesis. Med Sci Sports Exerc. 50(6):1177-1185, 2018.

Miyamoto N, Miyamoto-Mikami E, Hirata K, Kimura N, Fuku N. Association analysis of the ACTN3 R577X polymorphism with passive muscle stiffness and muscle strain injury. Scand J Med Sci Sports. 28(3):1209-1214, 2018.

Miyamoto N, Hirata K, Kimura N, Miyamoto-Mikami E. Contributions of Hamstring Stiffness to Straight-Leg-Raise and Sit-and-Reach Test Scores. Int J Sports Med. 39(2):110-114, 2018.

Miyamoto-Mikami E, Zempo H, Fuku N, Kikuchi N, Miyachi M, Murakami H. Heritability estimates of endurance-related phenotypes: A systematic review and meta-analysis. Scand J Med Sci Sports. 28(3):834-845, 2018.

Yvert T, Zempo H, Gabdrakhmanova LJ, Kikuchi N, Miyamoto-Mikami E, Murakami H, Naito H, Cieszczyk P, Leznicka K, Kostryukova ES, Alexeev DG, Egorova ES, Maciejewska-Skrendo A, Larin AK, Generozov EV, , Kulemin NA, Ospanova EA, Pavlenko AV, Sawczuk M, Żmijewski P, Lulinska-Kuklik E, Govorun VM, Miyachi M, Ahmetov I, Fuku N. AGTR2 and sprint/power performance: A case-control replication study for rs11091046 polymorphism in two ethnicities. Biology of Sport. 35(2):105–109, 2018.

【2017年】
Willems S, Wright D, Day D, Trajanoska K, Joshi P, Morris J, Matteini A, Garton F, Grarup N, Oskolkov N, Thalamuthu A, Mangino M, Liu J, Demirkan A, Lek M, Xu L, Wang G, Oldmeadow C, Gaulton K, Lotta L, Miyamoto-Mikami E, Rivas M, White T, Loh PR, Aadahl M, Amin N, Attia J, Austin K, Benyamin B, Brage S, Cheng YC, Cieszczyk P, Derave W, Eriksson KF, Eynon N, Linneberg A, Lucia A, Massidda M, Mitchell B, Miyachi M, Murakami H, Padmanabhan S, Pandey A, Papadimitriou I, Rajpal D, Sale C, Schnurr T, Sessa F, Shrine N, Tobin M, Varley I, Wain L, Wray N, Lindgren C, MacArthur D, Waterworth D, McCarthy M, Pedersen O, Khaw K, Kiel D, GEFOS Anytype of Fracture Consortium, Pitsiladis P, Fuku N, Franks P, North K, Duijn C, Mather K, Hansen T, Hansson O, Spector T, Murabito J, Richards B, Rivadeneira F, Langenberg C, Perry J, Wareham N, Scott R. Large-Scale GWAS Identifies Multiple Loci for Hand Grip Strength Providing Biological Insights into Muscular Fitness. Nat Commun. 8:16015, 2017.

Matsuo K, Sato K, Suemoto K, Miyamoto-Mikami E, Fuku N, Higashida K, Tsuji K, Xu Y, Liu X, Iemitsu M, Hamaoka T, Tabata I. A Mechanism Underlying Preventive Effect of High-Intensity Training on Colon Cancer. Med Sci Sports Exerc. 49(9):1805-1816, 2017.

Horii N, Hasegawa N, Fujie S, Uchida M, Miyamoto-Mikami E, Hashimoto T, Tabata I, Iemitsu M. High-intensity intermittent exercise training with chlorella intake accelerates exercise performance and muscle glycolytic and oxidative capacity in rats. Am J Physiol Regul Integr Comp Physiol. 312(4):R520-R528, 2017.

Zempo H, Miyamoto-Mikami E, Kikuchi N, Fuku N, Miyachi M, Murakami H. Heritability estimates of muscle strength-related phenotypes: A systematic review and meta-analysis. Scand J Med Sci Sports. 27(12):1537-1546, 2017.

Miyamoto-Mikami E, Murakami H, Tsuchie H, Takahashi H, Ohiwa N, Miyachi M, Kawahara T, Fuku N. Lack of association between genotype score and sprint/power performance in the Japanese population. J Sci Med Sport. 20(1):98-103, 2017.

宮本(三上) 恵里. スポーツパフォーマンスと遺伝子多型. トレーニング科学 29(2):103-110, 2017.

【2016年】
Yvert T, Miyamoto-Mikami E, Murakami H, Miyachi M, Kawahara T, Fuku N. Lack of replication of associations between multiple genetic polymorphisms and endurance athlete status in Japanese population. Physiol Rep. 4(20). pii: e13003, 2016

Hirata K, Miyamoto-Mikami E, Kanehisa H, Miyamoto N. Muscle-specific acute changes in passive stiffness of human triceps surae after stretching. Eur J Appl Physiol. 116(5):911-8, 2016.

Miyamoto-Mikami E, Fujita Y, Murakami H, Ito M, Miyachi M, Kawahara T, Fuku N. CNTFR Genotype and Sprint/power Performance: Case-control Association and Functional Studies. Int J Sports Med. 37(5):411-7, 2016.

Kikuchi N, Miyamoto-Mikami E, Murakami H, Nakamura T, Min SK, Mizuno M, Naito H, Miyachi M, Nakazato K, Fuku N. ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes. Eur J Sport Sci. 16(6):694-701, 2016.

村上晴香, 膳法浩史, 宮本(三上)恵里, 菊池直樹, 福典之. 運動能力・運動行動の遺伝率. 体力科学. 65(3):277-286, 2016.

【2015年】
Miyamoto-Mikami E, Sato K, Kurihara T, Hasegawa N, Fujie S, Fujita S, Sanada K, Hamaoka T, Tabata I, Iemitsu M. Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One. 10: e0120354, 2015.

Hirata K, Kanehisa H, Miyamoto-Mikami E, Miyamoto N. Evidence for intermuscle difference in slack angle in human triceps surae. J Biomech 48: 1210-1213, 2015.

【2014年】
Mikami E, Fuku N, Murakami H, Tsuchie H, Takahashi H, Ohiwa N, Tanaka H, Pitsiladis YP, Higuchi M, Miyachi M, Kawahara T, Tanaka M. ACTN3 R577X genotype is associated with sprinting in elite Japanese athletes. Int J Sports Med. 35: 172-177, 2014

Fujie S, Sato K, Miyamoto-Mikami E, Hasegawa N, Fujita S, Sanada K, Hamaoka T, Iemitsu M. Reduction of arterial stiffness by exercise training is associated with increasing plasma apelin level in middle-aged and older adults. PLoS One. 9: e93545, 2014.

【2013年】
Mikami E, Fuku N, Kong QP, Takahashi H, Ohiwa N, Murakami H, Miyachi M, Higuchi M, Tanaka M, Pitsiladis YP, Kawahara T. Comprehensive analysis of common and rare mitochondrial DNA variants in elite Japanese athletes: a case-control study. J Hum Genet. 58: 780-787, 2013.

Mikami E, Fuku N, Takahashi H, Ohiwa N, Pitsiladis YP, Higuchi M, Kawahara T, Tanaka M. Polymorphisms in the control region of mitochondrial DNA associated with elite Japanese athlete status. Scand J Med Sci Sports. 23: 593-599, 2013.

Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, Ito M, Endo S, Ihara K, Ohno K, Kishimoto Y, Ishigami A, Maruyama N, Sawabe M, Iseki H, Okazaki Y, Hasegawa-Ishii S, Takei S, Shimada A, Hosokawa M, Mori M, Higuchi K, Takeda T, Higuchi M, Tanaka M. Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics. 14: 248, 2013.

Wang G, Mikami E, Chiu LL, DE Perini A, Deason M, Fuku N, Miyachi M, Kaneoka K, Murakami H, Tanaka M, Hsieh LL, Hsieh SS, Caporossi D, Pigozzi F, Hilley A, Lee R, Galloway SD, Gulbin J, Rogozkin VA, Ahmetov II, Yang N, North KN, Ploutarhos S, Montgomery HE, Bailey ME, Pitsiladis YP. Association analysis of ACE and ACTN3 in elite Caucasian and East Asian swimmers. Med Sci Sports Exerc. 45: 892-900, 2013.

Pitsiladis Y, Wang G, Wolfarth B, Scott R, Fuku N, Mikami E, He Z, Fiuza-Luces C, Eynon N, Lucia A. Genomics of elite sporting performance: what little we know and necessary advances. Br J Sports Med. 47: 550-555, 2013.

Fuku N, Mikami E, Tanaka M. Mitochondrial DNA polymorphisms and/or haplogroups are associated with elite Japanese athlete status. The Journal of Physical Fitness and Sports Medicine. 2: 17-28, 2013.

【2012年】
Kato T, Nishigaki Y, Noguchi Y, Fuku N, Ito T, Mikami E, Kitamura K, Tanaka M. Extended screening for major mitochondrial DNA point mutations in patients with hereditary hearing loss. J Hum Genet. 57: 772-775, 2012.

【2011年】
Mikami E, Fuku N, Takahashi H, Ohiwa N, Scott RA, Pitsiladis YP, Higuchi M, Kawahara T, Tanaka M. Mitochondrial haplogroups associated with elite Japanese athlete status. Br J Sports Med. 45: 1179-1183, 2011.

斉藤太一, 福典之, 三上恵里, 川原貴, 田中宏暁, 樋口満, 田中雅嗣. ACTN3遺伝子のR577Xナンセンスアリルはエリートレベルの日本人中長距離選手において頻度が低い. 体力科学. 60: 443-451, 2011.

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