学校法人順天堂　研究者情報データベース:::研究業績詳細:::

HOME　＞　研究業績詳細

研究業績詳細

大熊泰之（オオクマヤスユキ）

研究テーマ	パーキンソン病の病態と治療
研究業績（論文）	＜英文原著・症例報告＞ Shiraishi M, Mikami K, Kamo H, Okuma Y, et al.The effect of subjective postural vertical on forward flexed posture in Parkinson's disease. Parkinsonism Relat Disord 2024 Morimoto R, Iijima M, Okuma Y, Suzuki K, Yoshii F, Nogawa S, Osada T, Kitagawa K. Associations between non-motor symptoms and patientcharacteristics in Parkinson’s disease: a multicenter cross-sectional study. Front Aging Neurosci 15, 1252596, 2023 Igami E, Fujimaki M, Shimizu M, Ishiguro Y, Kodama T, Okuma Y, Hattori N, Noda K. Reversible Pisa syndrome caused by chronic subdural hematoma in a patient with Parkinson’s disease: a case report. BMC Neurology 22;432, 2022 Baba T, Takeda A, Murakami A, Koga T, Isomura T, Mori E; DASH-PD study group. (Okuma Y. is a member of this study group.) Effect of donepezil for dementia prevention in Parkinson’s disease with severe hyposmia (The DASH-PD study): A randomized long-term placebo-controlled trial. eClinical Medicine 51:101571, 2022 Iijima M, Okuma Y, Suzuki K, Yoshii F, Nogawa S, Osada T, Hirata K, Kitagawa K, Hattori N. Associations between probable REM sleep disorder, olfactory disturbance, and clinical symptoms in Parkinson’s disease: A multicenter cross-sectional study. PLOS One 2021, e0247443 Ogawa T, Ogaki K, Daida K, Nishimaki T, Ando M, Kawajiri S, Wada R, Noda K, Hattori N, Okuma Y. Progressive encephalomyelitis with rigidity and myoclonus and myasthenia gravis comorbid status with thymoma. Mov Disord Clin Pract 8 (Suppl 1):S11-13, 2021 Balint B, Ogawa T, Ogaki K, Daida K, Nishimaki T, Ando M, Kawajiri S, Wada R, Noda K, Hattori N, Okuma Y, Barsottini O. Commentary: Progressive encephalomyelitis with rigidity and myoclonus and myasthenia gravis comorbid status with thymoma. Mov Disord Clin Pract 8 (Suppl 1):S14-15, 2021 Daida K, Ogaki K, Hayashida A, Ando M, Yokoyama K, Noda K, Kanbayashi T, Hattori N, Okuma Y. Somnolence preceded the development of a subthalamic lesion in neuromyelitis optica spectrum disorder. Intern Med 59;577-579, 2020 Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Haruyama Y, Kobashi G, Sakakibara R, Shimo Y, Hatano T, Hattori N, Yamamoto T, Hirano S, Yamamoto T, Kuwabara S, Kaji Y, Fujita H, Kadowaki T, Hirata K. Determinants of low body mass index in patients with Parkinson's disease: A multicenter case-control study. J Parkinson’s dis 10;213-221, 2020 Toyama M, Okuma Y, Yamamoto M, Kashihara K, Yoshida K, Saiki H, Maeda T, Tsuboi Y, Takahashi Y, Nakayama T. Non-motor symptoms depending on motor severity in Japanese patients with Parkinson’s disease: A multicenter cross-sectional study. J Neurol Sci 412;116641, 2020 Noda K, Ando M, Jo T, Hattori A, Ogaki K, Sugiyama M, Hattori N, Okuma Y. Mesial frontal lobe infarction presenting as Pisa syndrome. J Stroke Cerebrovasc Dis 2020, 104882 Ogawa T, Ogaki K, Ishiguro M, Ando M, Yoshida T, Noda K, Hattori N, Okuma Y. Novel GFAP p. Glu206Ala mutation in Alexander disease with decreased dopamine transporter uptake. Mov Disord Clin Pract 8;720-722, 2020 Ando Y, Fujimoto K-I, Ikeda K, Utsumi H, Okuma Y, Oka H, Kamei S, Kurita A, Takahashi K, Nogawa S, Hattori N, Hirata K, Fukui T, Yamazaki K, Yamamoto T, Yoshii F. Postural abnormality in Parkinson’s disease: a large comparative study with general population. Mov Disord Clin Pract 6: 213-221, 2019 Iijima M, Orimo S, Terashi H, Suzuki M, Hayashi A, Shimura H, Mitoma H, Kitagawa K, Okuma Y. Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson’s disease: A single-arm, open-label, prospective, multicenter study. Expert Opin Pharmacother 20: 1405-1411, 2019 Watanabe D, Matsunobe I, Okuma Y, Nagaoka M. Releasing forced grasp reflex by use of concomitant imitation behavior during rehabilitation of a stroke. BMJ case reports 12: e228304, 2019 Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N. Clinical characterization of definite autoimmune limbic encephalitis: a 30-case series. Intern Med 58:3369-3378, 2019 Okuma Y, Silva de Lima AL, Fukae J, Bloem BR, Snijders AH. A prospective study of falls in relation to freezing of gait and response fluctuations in Parkinson’s disease. Parkinsonism Relat Disord 46:30-35, 2018 Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N. Randomized, double-blind, multicenter trial of hydrogen water for Parkinson’s disease. Mov Disord 33:1505-1507, 2018 Mikasa M, Kanai K, Li Y, Yoshino H, Mogushi K, Hayashida A, Ikeda A, Kawajiri S, Okuma Y, Kashihara K, Sato T, Kondo H, Funayama M, Nishioka K, Hattori N. CoQ2 variants in Parkinson’s disease and multiple system atrophy. J Neural Transm (Vienna) 125:937-944, 2018 Mezaki N, Miura T, Ogaki K, Eriguchi M, Mizuno Y, Komatsu K, Yamazaki H, Suetsugu N, Kawajiri S, Yamasaki R, Ishiguro T, Konno T, Nozaki H, Kasuga K, Okuma Y, Kira J, Hara H, Onodera O, Ikeuchi K. Duplication and deletion upstream of LMNB1 in autosomal dominant adult onset leukodystrophy. Neurol Genet 4:e292, 2018 Youn J, Okuma Y, Hwang M, Kim D, Cho JW. Falling direction can predict the mechanism of recurrent falls in advanced Parkinson’s disease. Scientific Rep, 2017 Ouma S, Fukae J, Fujioka S, Yamamoto S, Hatano T, Yoritaka A, Okuma Y, Kashihara KI, Hattori N, Tsuboi Y. The risk factor for the wearing-off phenomenon in Parkinson’s disease in Japan: A cross-sectional, multicenter study. Intern Med 56:1961-1966, 2017 Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Numao A, Hirata K; Kanto NMPD investigators. Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson’s disease: A multicenter case-controlled study. Parkinsonism Relat Disord 44:18-22, 2017 Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Kadowaki T, Hirata K; Kanto NMPD investigators. Impact of sleep-related symptoms on clinical motor subtypes and disability in Parkinson’s disease: a multicenter cross-sectional study. J Neurol Neurosurg Psychiatry 88:953-959, 2017 Noda K, Hattori N, Okuma Y, Yamamoto T. Chronic subdural haematoma presenting as freezing of gait. BMJ Case Rep. 2017. pii: bcr-2017-221469. Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Suzuki S, Haruyama Y, Kobashi G, Hirata K; Kanto NMPD investigators. The prevalence, course and clinical correlates of migraine in Parkinson’s disease: A multicenter case-controlled study. Cephalalgia. 2017:333102417739302. Tomizawa Y, Nakamura R, Hoshimo Y, Sasaki F, Nakajima S, Kawajiri S, Noda K, Takanaashi M, Fujita N, Yokoyama K, Hattori N, Takahashi T, Okuma Y. Tumefactive demyelinating brain lesions with multiple closed-ring enhancement in the course of neuromyelitis optica. J Neurol Sci 361:49-51, 2016 Yoritaka A, Abe T, Ohtsuka C, Maeda T, Hirayama M, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama, Kihara T, Hirasawa M, Shimura H, Hattori N. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurology 16:66, 2016 Noda K. Hattori, N, Okuma Y. Re-emergent tremor in a patient with Parkinson’s disease. BMJ Case Rep 2016, bcr2016216436, 2016 Noda K, Ishimoto R, Hattori N, Okuma Y, Yamamoto T. Hemichorea improvement following endarterectomy for internal carotid artery stenosis. J Neurol Sci 371:45-47, 2016 Sasaki F, Kawajiri S, Nakajima S, Yamaguchi A, Tomizawa Y, Noda K, Hattori N, Okuma Y. Occipital lobe seizures and subcortical T2 and T2* hypointensity associated with nonketotic hyperglycemia: a case report. J Med Case Rep. 10:228, 2016 Kawajiri S, Hoshino Y, Nakamura R, Noda K, Tomizawa Y, Hattori N, Okuma Y. A case of painless legs and moving toes syndrome in Parkinson’s disease responsive to dopaminergic therapy. Case Rep Neurol Med. 2016:6829410, 2016 Miura Y, Devaux JJ, Fukami Y, Manso C, Belghazi M, Wong AHY, Yuki N, for the CNTN1-CIDP Study Group (Okuma Y. is a member of this study group). Contactin-1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia. Brain 138:1484-91, 2015 Noda K, Hattori N, Okuma Y. Hemiballism with leg predominance caused by contralateral subthalamic haemorrhage.BMJ Case Rep. 2015 bcr-2014-208525 Kawajiri S, Noda K, Ikeda A, Koinuma T, Tomizawa Y, Hattori N, Okuma Y. Low dose of clonazepam is effective in the treatment of Painless legs and moving toes syndrome: A case report. Case Rep Neurol 7:59-62, 2015. Tomizawa Y, Kanou K, Koinuma K, Misawa S, Shiotsuki H, Noda K, Hattori H, Okuma Y. Two cases of steroid responsive encephalomyelitis with reversible diffuse cerebral arterial stenosis: A case report and review of the literature. Clin Exper Neuroimmunol 6: 89–92, 2015 Fukae J, Higuchi M-A, Yanamoto S, Fukuhara K, Tsugawa J, Ouma S, Hatano T, Yoritaka A, Okuma Y, Kashihara K, Hattori N, Tsuboi Y. Utility of the Japanese version of the 9-item wearing-off questionnaire. Clin Neurol Neurosurgery 134:110–115, 2015 Tomizawa T, Hoshino Y, Sasaki F, Kurita N, Kawajiri S, Noda K, Hattori N, Maekawa J, Kura F, Okuma Y. The diagnostic utility of splenial lesion in a case of Legionnaires’ disease due to Legionella pneumophila serogroup 2. Intern Med 54:3079-3082, 2015 Tomizawa T, Okuzumi A, Shiotsuki H, Noda K, Hattori N, Okuma Y. A patient with the GLA p.E66Q mutation exhibiting vascular parkinsonism and bilateral pulvinar lesions. Intern Med 54:2503-2506, 2015 Fujimaki M, Kawajiri S, Ichikawa K, Tomizawa Y, Noda K, Hattori N, Koike M, Okuma Y. Lymphomatoid granulomatosis with central nervous system involvement successfully treated with cyclophosphamide, high-dose cytarabin, dexamethasone, etoposide, and rituximab (CHASER therapy) : Case study. CNS Neuroscience & Therapeutics 21:610-612, 2015 Noda K, Kawajiri S, Tomizawa Y, Hattori N, Okuma Y. Pisa syndrome in progreesive supranuclear palsy: a case report. Parkinsonism Relat Disord 21:1115-1116, 2015 Tanaka R, Yamashiro K, Okuma Y, Shimura H, Nakamura S, Ueno Y, Tanaka Y, Miyamoto N, Tomizawa Y, Nakahara T, Furukawa Y, Watada H, Kawamori R, Hattori N, Urabe T. Effects of pioglitazone for secondary stroke prevention in patients with impaired glucose tolerance and newly diagnosed diabetes: The J-SPIRIT study. J Atheroscler Thromb. 22:1305-1316, 2015 Murata M, Hasegawa K, Kanazawa I, Fukasaka J, Kichi K, Shimazu R; Japan zonisamide on PD Study Group (Y. Okuma is a member of this study group). Zonisamide improves wearing-off in Parkinson’s disease: A randomized, double-blind study. Mov Disord 30:1343-1350, 2015 Noda K, Nakajima S, Sasaki F, Ito Y, Kawajiri S, Tomizawa Y, Hattori N, Okuma Y. Middle cerebral artery occlusion presenting as upper limb monochorea. J Stroke Cerebrovascular Dis 24:e-291-293, 2015 Noda K, Tosaka Y, Ishiguro Y, Kawajiri S, Tomizawa Y, Hattori N, Okuma Y. Delayed chorea after recovery from severe akinetic-rigid parkinsonism caused by extrapontine myelinolysis. J Neurol Sci 358:498-500, 2015 Yamashiro K, Tanaka R, Okuma Y, Ueno Y, Tanaka Y, Hattori N. Associations of durations of antiplatelet use and vascular risk factors with the presence of cerebral microbleeds. J Stroke Cerebrovasc Dis 23;433-440,2014 Noda K, Hattori N, Okuma Y. Primary central nervous system lymphoma presenting as choreoathetosis. BMJ Case Rep. 2014 Apr 16 Yoneyama M, Okuma Y, Utsumi H, Terashi H, Mitoma H. Human turnover dynamics during sleep: statistical behavior and its modeling. Phys Rev E Stat Nonlin Soft Matter Phys. 89:032721, 2014 Yamashiro K, Tanaka R, Okuma Y, Shimura H, Ueno Y, Miyamoto N, Urabe T, Hattori N. Cerebral microbleeds are associated with worse cognitive function in the nondemented elderly with small vessel disease. Cerebrovasc Dis Extra 4:212–220, 2014 Okuma Y. A patient-invented maneuver to alleviate freezing of gait using a foot loop band. Case Rep Neurol 6:256–258, 2014 Kashihara K, Kondo T, Mizuno Y, Kikuchi S, Kuno S, Hasegawa K, Hattori N, Mochizuki H, Mori H, Murata M, Nomoto M, Takahashi R, Takeda A, Tsuboi Y, Ugawa Y, Yamanmoto M, Yokochi F, Yoshii F, Stebbins GT, Tilley BC, Luo S, Wang L, LaPelle NR, Goetz CG; MDS-UPDRS Japanese Validation Study Group (Okuma Y. is a member of this study group). Official Japanese version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale: validation against the original English version. Mov Disord Clin Pract 1:200-212, 2014 Okuma Y. Practical approach to freezing of gait in Parkinson’s disease. Pract Neurol 14:222-230, 2014 Okuma Y. Freezing of gait and falls in Parkinson’s disease. J Parkinson’s disease 4:255-260, 2014 Utsumi H, Okuma Y, Kano O, Suzuki Y, Iijima M, Tomimitsu H, Hashida H, Kubo S, Suzuki M, Nanri K, Matsumura M, Murakami H, Hattori N. Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson’s disease. Intern Med 52:325-332, 2013 Yoneyama M, Mitoma H, Okuma Y. Accelerometry-based long-term monitoring of movement disorders: from diurnal gait behavior to nocturnal bed mobility. J Mechanics Med Biol 13; 1350041, 2013 Fuse A, Yamashiro K, Oji Y, Furuya T, Noda K, Hattori N, Okuma Y. Reversible focal cerebral cortical lesions in a patient with heat stroke. Intern Med 52;377-380, 2013 Mori A, Hira K-I, Hatano T, Okuma Y, Kubo S-I, Hirano K, Ohno K, Noda K, Suzuki H, Ohsawa I, Hattori N. Bilateral facial nerve palsy due to otitis media associated with myeloperoxidase-amtineutrophil cytoplasmic antibody. Am J Med Sci 346;240-243,2013 Oji Y, Noda K, Tokugawa J, Hattori N, Okuma Y, Yamashiro K. Spontaneous spinal subarachnoid hemorrhage after severe coughing: a case report. J Med Case Reports 7;274, 2013 Utsumi H, Terashi H, Ishimura Y, Takazawa T, Hayashi A, Mochizuki H, Okuma Y, Orimo S, Takahashi T, Yoneyama M, Mitoma H. Quantitative assessment of gait bradykinesia in Parkinson’s disease using a portable gait rhythmogram. Acta Medica Okayama 66:31-40, 2012 Ogaki K, Hirayama T, Chijiiwa K, Fukae J, Furuya T, Noda K, Fujishima K, Hattori N, Takahashi T, Okuma Y. Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis. Neurologist 18:76-79, 2012 (corresponding author) Terashi H, Utsumi H, Ishimura Y, Takazawa T, Okuma Y, Yoneyama M, Mitoma H. Deficits in scaling of gait force and cycle in parkinsonian gait identified by long-term monitoring of acceleration with the portable gait rhythmogram. ISRN Neurology Volume 2012, Article ID 306816, 8 pages Utsumi H, Terashi H, Ishimura Y, Takazawa T, Okuma Y, Yoneyama M, Mitoma H. How far do the complaints of patients with Parkinson’s disease reflect motor fluctuation? Quantitative analysis using a portable gait ryhthmogram. ISRN Neurology Volume 2012, Article ID Noda K, Fukae J, Fujishima K, Mori K, Urabe T, Hattori N, Okuma Y. Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage, reversible posterior leukoencephalopathy, and cerebral infarction. Intern Med. 50:1227-1233, 2011 Akiba C, Esaki T, Ando M, Furuya T, Noda K, Nakao Y, Yamamoto T, Okuma Y, Mori K. Possible neuro-Sweet disease mimicking brain tumor in the medulla oblongata--case report. Neurol Med Chir 51:140-143, 2011. Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y. Cerebral infarction developing in a non-cancer patient with a markedly elevated level of mucinous tumor marker. J Stroke Cerebrovasc Dis, 2011 Yamashiro K, Mori A, Shimada Y, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y. Gradient echo T2-weighted MRI demonstrating cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease. J Stroke Cerebrovasc Dis, 2011 Ando M, Yamashiro K, Noda K, Okuma Y. Aquaporin-4 autoimmunity can cause exclusive brain tumefactive lesions. Intern Med 50:2437-2438, 2011 Morita A, Okuma Y, Kamei S, Yoshii F, Yamamoto T, Hashimoto S, Utsumi H, Hatano T, Hattori N, Matsumura M, Takahashi K, Nogawa S, Watanabe Y, Miyamoto T, Miyamoto M, Hirata K. Pramipexole reduces the prevalence of fatigue in patients with Parkinson's disease. Intern Med 50:2163-2168, 2011. Yamashiro K, Tanaka R, Nishioka K, Ueno Y, Shimura H, Hattori N, Okuma Y, Urabe T. Cerebral infarcts associated with adenomyosis among middle-aged women. J Stroke Cerebrovasc Dis, 2011 Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y. Convulsive movements in bilateral paramedian thalamic and midbrain infarction. Case Rep Neurol 3:289-293, 2011 Yoshida T, Sasaki M, Yoshida M, Namekawa M, Okamoto Y, Tsujino S, Sasayama H, Mizuta I, Nakagawa M; Alexander Disease Study Group in Japan (Y Okuma is a member of this study group). Nationwide survey of Alexander disease in Japan and proposed new guidelines for diagnosis. J Neurol 258:1998-2008,2011. ＜英文著書＞ Okuma Y, Mizuno Y. Electrophysiology and other auxiliary investigations. In Cognitive impairment and dementia in Parkinson’s disease. 2nd edition. Ed. by Emre M. Oxford University Press, Oxford, UK, 153-162, 2015 Okuma Y, Mizuno Y. Electrophysiology and other auxiliary investigations. In Dementia in Parkinson’s Disease. Ed. by Emre M. Oxford University Press, Oxford, UK, 2010 ＜英文総説＞ Silva de Lima AL, 他５名, Okuma Y, Bloem BR, Faber MJ. Freezing of gait and fall detection in Parkinson's disease using wearable sensors: a systematic review. J Neurol. 2017 doi: 10.1007/s00415-017-8424-0. [Epub ahead of print] Okuma Y. Practical approach to freezing of gait in Parkinson’s disease. Pract Neurol 14:222-230, 2014 Okuma Y. Freezing of gait and falls in Parkinson’s disease. J Parkinson’s disease 4:255-260, 2014 Okuma Y, Yanagisawa N. The clinical spectrum of freezing of gait in Parkinson’s disease. Mov Disord 23(Suppl 2) :S426-430, 2008 Okuma Y. Freezing of gait in Parkinson’s disease. J Neurol 253 (suppl 7) :vii27-vii32, 2006 ＜和文著書・テキスト＞大熊泰之. 機能性歩行障害.　機能性神経障害診療ハンドブック.　下畑享良編著　中外医学社　2024, pp256-267 大熊泰之. すくみ足.　パーキンソン病の理学療法.　奈良　勲監修、松尾善美、石井光昭編、医歯薬出版　2020、pp 41-54. 大熊泰之. 歩行障害.　神経症候学と神経診断学 – AIは味方か敵か？ - Clinical Neuroscience 38:1453-1456, 2020 大熊泰之. パーキンソン病のすくみ足と転倒. パーキンソン病200年 – James Parkinsonの夢 -. 山本光利編、中外医学社、2019年、pp158-161 大熊泰之. すくみ足はどのように治療したらよいでしょうか？抗パーキンソン病薬で増悪するすくみ足もありますか？　神経内科clinical questions and pearls: パーキンソン病. 鈴木則宏監修、服部信孝、下　泰司、波田野　琢編、中外医学社　2019, pp243-247 大熊泰之. パーキンソン病の歩行障害の特徴. パーキンソン病のリハビリテーョン. 林　明人編、日本医事新報　2018, pp47-52 大熊泰之．第３章症候から鑑別診断へ．てんかん．神経内科ハンドブック第５版，水野美邦編集，医学書院，東京，2016 大熊泰之．第４章神経学的検査法．生理学的検査．神経内科ハンドブック第５版，水野美邦編集，医学書院，東京，2016 大熊泰之．第５章診断と治療．脊椎疾患．神経内科ハンドブック第５版，水野美邦編集，医学書院，東京，2016 大熊泰之．転倒（歩行障害）．パーキンソン病・パーキンソン症候群の在宅ケア．佐藤猛，服部信孝，村田美穂編，中央法規，東京，2016, pp132-138. 大熊泰之．セクションIII．神経症候の診かた. 23.異常姿勢の診かた．臨床神経内科学改訂６版．平山恵造監修，廣瀬源二郎，田代邦雄，葛原茂樹編集，南山堂，東京，2016, pp237-241 大熊泰之．セクションIII．神経症候の診かた. 24.起立・歩行障害の診かた．臨床神経内科学改訂６版．平山恵造監修，廣瀬源二郎，田代邦雄，葛原茂樹編集，南山堂，東京，2016, pp242-250 河尻澄宏，大熊泰之.進行性核上性麻痺，皮質基底核変性症．神経疾患最新の治療2015-2017. p156-158. 南江堂 2015. 大熊泰之．進行期治療をどうするか？（運動合併症の対処，姿勢異常，すくみ，転倒への対処）．インフォームドコンセントのための図説シリーズ：パーキンソン病．武田篤編，医薬ジャーナル社，2013, pp64-73. 大熊泰之．パーキンソン病のすくみ足ってどんな症状なの？ jmedあなたも名医．ここを押さえる，パーキンソン病診療．服部信孝編，日本医事新報社2012. P45-50. 大熊泰之．パーキンソン病治療における抗コリン薬の位置づけは？ jmedあなたも名医．ここを押さえる，パーキンソン病診療．日本医事新報社2012. P73-76. 塩月寛美，大熊泰之．変性疾患　—パーキンソン病を中心として−．神経救急・集中治療ハンドブック2012 大垣光太郎，大熊泰之．歩行障害　−責任病巣はどこか−．すべての内科医が知っておきたい神経疾患の診かた考え方とその対応．大生定義編，羊土社 2012 pp77 大熊泰之．パーキンソン病の転倒防止と寝たきり予防．GP・レジデントのためのパーキンソン病テキストブック．山本光利編，アルタ出版 2012. p218-227 大熊泰之．すくみ足．パーキンソン病の理学療法．奈良勲，松尾善美編．医歯薬出版，東京，37-47, 2011 波田野　琢，波田野靖子，大熊泰之：パーキンソニズムと紛らわしい症状．よくわかるパーキンソン病のすべて．水野美邦，近藤智善編．永井書店，大阪，347-358, 2011 大熊泰之：パーキンソン病の病態生理．よくわかるパーキンソン病のすべて．水野美邦，近藤智善編．永井書店，大阪，389-401, 2011 大熊泰之．第３章症候から鑑別診断へ．てんかん．神経内科ハンドブック第４版，水野美邦編集，医学書院，東京，2010, pp187-213 大熊泰之．第４章神経学的検査法．生理学的検査．神経内科ハンドブック第４版，水野美邦編集，医学書院，東京，2010, pp457-500 大熊泰之．第５章診断と治療．脊椎疾患．神経内科ハンドブック第４版，水野美邦編集，医学書院，東京，2010, pp1012-1026 大熊泰之：パーキンソン病におけるアパシーの臨床症状と評価．Parkinson’s Disease 2010. 山本光利編．アルタ出版．2010, pp102-111. 大熊泰之：minipolymyoclonusについて．パーキンソン病診療Q&A.水野美邦編．中外医学社．2009.pp 7-9. 大熊泰之：パーキンソン病治療における抗コリン薬の位置づけは？．服部信孝編．日本医事新報社．2009.pp 57-60. 大熊泰之：熱性けいれん．疾患と薬物治療．知っておきたいcommon disease 101. 富野康日己，望月正隆編．医歯薬出版．2008, pp290-292. 大熊泰之：Dopamine agonists. EBMのコンセプトを取り入れたパーキンソン病ハンドブック（改訂2版）. 水野美邦編. 中外医学社，東京, 2007, pp117-141 ＜研究助成金等＞車椅子上の足底接地の条件に着目した誤嚥防止に有効な座位姿勢の解明（分担研究者）.日本学術振興会科学研究費補助金. 基盤研究(C). 2023年度 - 2026年度. LCIG療法を受ける進行期パーキンソン病患者の在宅療養を支える看護の構築（分担研究者）.日本学術振興会科学研究費補助金.　基盤研究(C). 2021年度 - 2023年度. 重度嗅覚障害を呈するパーキンソン病を対象としたドネペジルの予後改善効果に関する研究（分担研究者）. 厚生労働科学研究費補助金→国立研究開発法人日本医療研究開発機構（AMED）臨床研究・治験推進研究事業 2012年度-2016年度. 独立成分解析による脳死判定のための脳波信号処理（分担研究者）.日本学術振興会科学研究費補助金. 基盤研究(B) 2000年度-2001年度. A型ボツリヌス菌毒素の筋肉内限局投与法による不随意運動の治療（研究代表者）. 日本学術振興会科学研究費補助金. 奨励研究(A)　1991年度.

研究テーマ

パーキンソン病の病態と治療

研究業績（論文）

＜英文原著・症例報告＞

Shiraishi M, Mikami K, Kamo H, Okuma Y, et al.The effect of subjective postural vertical on forward flexed posture in Parkinson's disease. Parkinsonism Relat Disord 2024

Morimoto R, Iijima M, Okuma Y, Suzuki K, Yoshii F, Nogawa S, Osada T, Kitagawa K. Associations between non-motor symptoms and patientcharacteristics in Parkinson’s disease: a multicenter cross-sectional study. Front Aging Neurosci 15, 1252596, 2023

Igami E, Fujimaki M, Shimizu M, Ishiguro Y, Kodama T, Okuma Y, Hattori N, Noda K. Reversible Pisa syndrome caused by chronic subdural hematoma in a patient with Parkinson’s disease: a case report. BMC Neurology 22;432, 2022

Baba T, Takeda A, Murakami A, Koga T, Isomura T, Mori E; DASH-PD study group. (Okuma Y. is a member of this study group.) Effect of donepezil for dementia prevention in Parkinson’s disease with severe hyposmia (The DASH-PD study): A randomized long-term placebo-controlled trial. eClinical Medicine 51:101571, 2022

Iijima M, Okuma Y, Suzuki K, Yoshii F, Nogawa S, Osada T, Hirata K, Kitagawa K, Hattori N. Associations between probable REM sleep disorder, olfactory disturbance, and clinical symptoms in Parkinson’s disease: A multicenter cross-sectional study. PLOS One 2021, e0247443

Ogawa T, Ogaki K, Daida K, Nishimaki T, Ando M, Kawajiri S, Wada R, Noda K, Hattori N, Okuma Y.
Progressive encephalomyelitis with rigidity and myoclonus and myasthenia gravis comorbid status with thymoma. Mov Disord Clin Pract 8 (Suppl 1):S11-13, 2021

Balint B, Ogawa T, Ogaki K, Daida K, Nishimaki T, Ando M, Kawajiri S, Wada R, Noda K, Hattori N, Okuma Y, Barsottini O. Commentary: Progressive encephalomyelitis with rigidity and myoclonus and myasthenia gravis comorbid status with thymoma. Mov Disord Clin Pract 8 (Suppl 1):S14-15, 2021

Daida K, Ogaki K, Hayashida A, Ando M, Yokoyama K, Noda K, Kanbayashi T, Hattori N, Okuma Y. Somnolence preceded the development of a subthalamic lesion in neuromyelitis optica spectrum disorder. Intern Med 59;577-579, 2020

Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Haruyama Y, Kobashi G, Sakakibara R, Shimo Y, Hatano T, Hattori N, Yamamoto T, Hirano S, Yamamoto T, Kuwabara S, Kaji Y, Fujita H, Kadowaki T, Hirata K. Determinants of low body mass index in patients with Parkinson's disease: A multicenter case-control study. J Parkinson’s dis 10;213-221, 2020

Toyama M, Okuma Y, Yamamoto M, Kashihara K, Yoshida K, Saiki H, Maeda T, Tsuboi Y, Takahashi Y, Nakayama T. Non-motor symptoms depending on motor severity in Japanese patients with Parkinson’s disease: A multicenter cross-sectional study. J Neurol Sci 412;116641, 2020

Noda K, Ando M, Jo T, Hattori A, Ogaki K, Sugiyama M, Hattori N, Okuma Y. Mesial frontal lobe infarction presenting as Pisa syndrome. J Stroke Cerebrovasc Dis 2020, 104882

Ogawa T, Ogaki K, Ishiguro M, Ando M, Yoshida T, Noda K, Hattori N, Okuma Y. Novel GFAP p. Glu206Ala mutation in Alexander disease with decreased dopamine transporter uptake. Mov Disord Clin Pract 8;720-722, 2020

Ando Y, Fujimoto K-I, Ikeda K, Utsumi H, Okuma Y, Oka H, Kamei S, Kurita A, Takahashi K, Nogawa S, Hattori N, Hirata K, Fukui T, Yamazaki K, Yamamoto T, Yoshii F. Postural abnormality in Parkinson’s disease: a large comparative study with general population. Mov Disord Clin Pract 6: 213-221, 2019

Iijima M, Orimo S, Terashi H, Suzuki M, Hayashi A, Shimura H, Mitoma H, Kitagawa K, Okuma Y. Efficacy of istradefylline for gait disorders with freezing of gait in Parkinson’s disease: A single-arm, open-label, prospective, multicenter study. Expert Opin Pharmacother 20: 1405-1411, 2019

Watanabe D, Matsunobe I, Okuma Y, Nagaoka M. Releasing forced grasp reflex by use of concomitant imitation behavior during rehabilitation of a stroke. BMJ case reports 12: e228304, 2019

Shojima Y, Nishioka K, Watanabe M, Jo T, Tanaka K, Takashima H, Noda K, Okuma Y, Urabe T, Yokoyama K, Hattori N. Clinical characterization of definite autoimmune limbic encephalitis: a 30-case series. Intern Med 58:3369-3378, 2019

Okuma Y, Silva de Lima AL, Fukae J, Bloem BR, Snijders AH. A prospective study of falls in relation to freezing of gait and response fluctuations in Parkinson’s disease. Parkinsonism Relat Disord 46:30-35, 2018

Yoritaka A, Ohtsuka C, Maeda T, Hirayama M, Abe T, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Oda E, Ito M, Ohno K, Hattori N. Randomized, double-blind, multicenter trial of hydrogen water for Parkinson’s disease. Mov Disord 33:1505-1507, 2018

Mikasa M, Kanai K, Li Y, Yoshino H, Mogushi K, Hayashida A, Ikeda A, Kawajiri S, Okuma Y, Kashihara K, Sato T, Kondo H, Funayama M, Nishioka K, Hattori N. CoQ2 variants in Parkinson’s disease and multiple system atrophy. J Neural Transm (Vienna) 125:937-944, 2018

Mezaki N, Miura T, Ogaki K, Eriguchi M, Mizuno Y, Komatsu K, Yamazaki H, Suetsugu N, Kawajiri S, Yamasaki R, Ishiguro T, Konno T, Nozaki H, Kasuga K, Okuma Y, Kira J, Hara H, Onodera O, Ikeuchi K. Duplication and deletion upstream of LMNB1 in autosomal dominant adult onset leukodystrophy. Neurol Genet 4:e292, 2018

Youn J, Okuma Y, Hwang M, Kim D, Cho JW. Falling direction can predict the mechanism of recurrent falls in advanced Parkinson’s disease. Scientific Rep, 2017

Ouma S, Fukae J, Fujioka S, Yamamoto S, Hatano T, Yoritaka A, Okuma Y, Kashihara KI, Hattori N, Tsuboi Y. The risk factor for the wearing-off phenomenon in Parkinson’s disease in Japan: A cross-sectional, multicenter study. Intern Med 56:1961-1966, 2017

Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Numao A, Hirata K; Kanto NMPD investigators. Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson’s disease: A multicenter case-controlled study. Parkinsonism Relat Disord 44:18-22, 2017

Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Kadowaki T, Hirata K; Kanto NMPD investigators. Impact of sleep-related symptoms on clinical motor subtypes and disability in Parkinson’s disease: a multicenter cross-sectional study. J Neurol Neurosurg Psychiatry 88:953-959, 2017

Noda K, Hattori N, Okuma Y, Yamamoto T. Chronic subdural haematoma presenting as freezing of gait. BMJ Case Rep. 2017. pii: bcr-2017-221469.

Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, Hattori N, Kuwabara S, Yamamoto T, Kaji Y, Hirano S, Suzuki S, Haruyama Y, Kobashi G, Hirata K; Kanto NMPD investigators. The prevalence, course and clinical correlates of migraine in Parkinson’s disease: A multicenter case-controlled study. Cephalalgia. 2017:333102417739302.

Tomizawa Y, Nakamura R, Hoshimo Y, Sasaki F, Nakajima S, Kawajiri S, Noda K, Takanaashi M, Fujita N, Yokoyama K, Hattori N, Takahashi T, Okuma Y. Tumefactive demyelinating brain lesions with multiple closed-ring enhancement in the course of neuromyelitis optica. J Neurol Sci 361:49-51, 2016

Yoritaka A, Abe T, Ohtsuka C, Maeda T, Hirayama M, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama, Kihara T, Hirasawa M, Shimura H, Hattori N. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurology 16:66, 2016

Noda K. Hattori, N, Okuma Y. Re-emergent tremor in a patient with Parkinson’s disease. BMJ Case Rep 2016, bcr2016216436, 2016

Noda K, Ishimoto R, Hattori N, Okuma Y, Yamamoto T. Hemichorea improvement following endarterectomy for internal carotid artery stenosis. J Neurol Sci 371:45-47, 2016

Sasaki F, Kawajiri S, Nakajima S, Yamaguchi A, Tomizawa Y, Noda K, Hattori N, Okuma Y. Occipital lobe seizures and subcortical T2 and T2* hypointensity associated with nonketotic hyperglycemia: a case report. J Med Case Rep. 10:228, 2016

Kawajiri S, Hoshino Y, Nakamura R, Noda K, Tomizawa Y, Hattori N, Okuma Y. A case of painless legs and moving toes syndrome in Parkinson’s disease responsive to dopaminergic therapy. Case Rep Neurol Med. 2016:6829410, 2016

Miura Y, Devaux JJ, Fukami Y, Manso C, Belghazi M, Wong AHY, Yuki N, for the CNTN1-CIDP Study Group (Okuma Y. is a member of this study group). Contactin-1 IgG4 associates to chronic inflammatory demyelinating polyneuropathy with sensory ataxia. Brain 138:1484-91, 2015

Noda K, Hattori N, Okuma Y. Hemiballism with leg predominance caused by contralateral subthalamic haemorrhage.BMJ Case Rep. 2015 bcr-2014-208525

Kawajiri S, Noda K, Ikeda A, Koinuma T, Tomizawa Y, Hattori N, Okuma Y. Low dose of clonazepam is effective in the treatment of Painless legs and moving toes syndrome: A case report. Case Rep Neurol 7:59-62, 2015.

Tomizawa Y, Kanou K, Koinuma K, Misawa S, Shiotsuki H, Noda K, Hattori H, Okuma Y. Two cases of steroid responsive encephalomyelitis with reversible diffuse cerebral arterial stenosis: A case report and review of the literature. Clin Exper Neuroimmunol 6: 89–92, 2015

Fukae J, Higuchi M-A, Yanamoto S, Fukuhara K, Tsugawa J, Ouma S, Hatano T, Yoritaka A, Okuma Y, Kashihara K, Hattori N, Tsuboi Y. Utility of the Japanese version of the 9-item wearing-off questionnaire. Clin Neurol Neurosurgery 134:110–115, 2015

Tomizawa T, Hoshino Y, Sasaki F, Kurita N, Kawajiri S, Noda K, Hattori N, Maekawa J, Kura F, Okuma Y. The diagnostic utility of splenial lesion in a case of Legionnaires’ disease due to Legionella pneumophila serogroup 2. Intern Med 54:3079-3082, 2015

Tomizawa T, Okuzumi A, Shiotsuki H, Noda K, Hattori N, Okuma Y. A patient with the GLA p.E66Q mutation exhibiting vascular parkinsonism and bilateral pulvinar lesions. Intern Med 54:2503-2506, 2015

Fujimaki M, Kawajiri S, Ichikawa K, Tomizawa Y, Noda K, Hattori N, Koike M, Okuma Y. Lymphomatoid granulomatosis with central nervous system involvement successfully treated with cyclophosphamide, high-dose cytarabin, dexamethasone, etoposide, and rituximab (CHASER therapy) : Case study. CNS Neuroscience & Therapeutics 21:610-612, 2015

Noda K, Kawajiri S, Tomizawa Y, Hattori N, Okuma Y. Pisa syndrome in progreesive supranuclear palsy: a case report. Parkinsonism Relat Disord 21:1115-1116, 2015

Tanaka R, Yamashiro K, Okuma Y, Shimura H, Nakamura S, Ueno Y, Tanaka Y, Miyamoto N, Tomizawa Y, Nakahara T, Furukawa Y, Watada H, Kawamori R, Hattori N, Urabe T. Effects of pioglitazone for secondary stroke prevention in patients with impaired glucose tolerance and newly diagnosed diabetes: The J-SPIRIT study. J Atheroscler Thromb. 22:1305-1316, 2015

Murata M, Hasegawa K, Kanazawa I, Fukasaka J, Kichi K, Shimazu R; Japan zonisamide on PD Study Group (Y. Okuma is a member of this study group). Zonisamide improves wearing-off in Parkinson’s disease: A randomized, double-blind study. Mov Disord 30:1343-1350, 2015

Noda K, Nakajima S, Sasaki F, Ito Y, Kawajiri S, Tomizawa Y, Hattori N, Okuma Y. Middle cerebral artery occlusion presenting as upper limb monochorea. J Stroke Cerebrovascular Dis 24:e-291-293, 2015

Noda K, Tosaka Y, Ishiguro Y, Kawajiri S, Tomizawa Y, Hattori N, Okuma Y. Delayed chorea after recovery from severe akinetic-rigid parkinsonism caused by extrapontine myelinolysis. J Neurol Sci 358:498-500, 2015

Yamashiro K, Tanaka R, Okuma Y, Ueno Y, Tanaka Y, Hattori N. Associations of durations of antiplatelet use and vascular risk factors with the presence of cerebral microbleeds. J Stroke Cerebrovasc Dis 23;433-440,2014

Noda K, Hattori N, Okuma Y. Primary central nervous system lymphoma presenting as choreoathetosis. BMJ Case Rep. 2014 Apr 16

Yoneyama M, Okuma Y, Utsumi H, Terashi H, Mitoma H. Human turnover dynamics during sleep: statistical behavior and its modeling. Phys Rev E Stat Nonlin Soft Matter Phys. 89:032721, 2014

Yamashiro K, Tanaka R, Okuma Y, Shimura H, Ueno Y, Miyamoto N, Urabe T, Hattori N. Cerebral microbleeds are associated with worse cognitive function in the nondemented elderly with small vessel disease. Cerebrovasc Dis Extra 4:212–220, 2014

Okuma Y. A patient-invented maneuver to alleviate freezing of gait using a foot loop band. Case Rep Neurol 6:256–258, 2014

Kashihara K, Kondo T, Mizuno Y, Kikuchi S, Kuno S, Hasegawa K, Hattori N, Mochizuki H, Mori H, Murata M, Nomoto M, Takahashi R, Takeda A, Tsuboi Y, Ugawa Y, Yamanmoto M, Yokochi F, Yoshii F, Stebbins GT, Tilley BC, Luo S, Wang L, LaPelle NR, Goetz CG; MDS-UPDRS Japanese Validation Study Group (Okuma Y. is a member of this study group). Official Japanese version of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale: validation against the original English version. Mov Disord Clin Pract 1:200-212, 2014

Okuma Y. Practical approach to freezing of gait in Parkinson’s disease. Pract Neurol 14:222-230, 2014

Okuma Y. Freezing of gait and falls in Parkinson’s disease. J Parkinson’s disease 4:255-260, 2014

Utsumi H, Okuma Y, Kano O, Suzuki Y, Iijima M, Tomimitsu H, Hashida H, Kubo S, Suzuki M, Nanri K, Matsumura M, Murakami H, Hattori N. Evaluation of the efficacy of pramipexole for treating levodopa-induced dyskinesia in patients with Parkinson’s disease. Intern Med 52:325-332, 2013

Yoneyama M, Mitoma H, Okuma Y. Accelerometry-based long-term monitoring of movement disorders: from diurnal gait behavior to nocturnal bed mobility. J Mechanics Med Biol 13; 1350041, 2013

Fuse A, Yamashiro K, Oji Y, Furuya T, Noda K, Hattori N, Okuma Y. Reversible focal cerebral cortical lesions in a patient with heat stroke. Intern Med 52;377-380, 2013

Mori A, Hira K-I, Hatano T, Okuma Y, Kubo S-I, Hirano K, Ohno K, Noda K, Suzuki H, Ohsawa I, Hattori N. Bilateral facial nerve palsy due to otitis media associated with myeloperoxidase-amtineutrophil cytoplasmic antibody. Am J Med Sci 346;240-243,2013

Oji Y, Noda K, Tokugawa J, Hattori N, Okuma Y, Yamashiro K. Spontaneous spinal subarachnoid hemorrhage after severe coughing: a case report. J Med Case Reports 7;274, 2013

Utsumi H, Terashi H, Ishimura Y, Takazawa T, Hayashi A, Mochizuki H, Okuma Y, Orimo S, Takahashi T, Yoneyama M, Mitoma H. Quantitative assessment of gait bradykinesia in Parkinson’s disease using a portable gait rhythmogram. Acta Medica Okayama 66:31-40, 2012

Ogaki K, Hirayama T, Chijiiwa K, Fukae J, Furuya T, Noda K, Fujishima K, Hattori N, Takahashi T, Okuma Y. Anti-aquaporin-4 antibody-positive definite neuromyelitis optica in a patient with thymectomy for myasthenia gravis. Neurologist 18:76-79, 2012
(*corresponding author)

Terashi H, Utsumi H, Ishimura Y, Takazawa T, Okuma Y, Yoneyama M, Mitoma H. Deficits in scaling of gait force and cycle in parkinsonian gait identified by long-term monitoring of acceleration with the portable gait rhythmogram. ISRN Neurology Volume 2012, Article ID 306816, 8 pages

Utsumi H, Terashi H, Ishimura Y, Takazawa T, Okuma Y, Yoneyama M, Mitoma H. How far do the complaints of patients with Parkinson’s disease reflect motor fluctuation? Quantitative analysis using a portable gait ryhthmogram. ISRN Neurology Volume 2012, Article ID

Noda K, Fukae J, Fujishima K, Mori K, Urabe T, Hattori N, Okuma Y. Reversible cerebral vasoconstriction syndrome presenting as subarachnoid hemorrhage, reversible posterior leukoencephalopathy, and cerebral infarction. Intern Med. 50:1227-1233, 2011

Akiba C, Esaki T, Ando M, Furuya T, Noda K, Nakao Y, Yamamoto T, Okuma Y, Mori K. Possible neuro-Sweet disease mimicking brain tumor in the medulla oblongata--case report. Neurol Med Chir 51:140-143, 2011.

Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y. Cerebral infarction developing in a non-cancer patient with a markedly elevated level of mucinous tumor marker. J Stroke Cerebrovasc Dis, 2011

Yamashiro K, Mori A, Shimada Y, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y. Gradient echo T2*-weighted MRI demonstrating cerebral microbleeds in a patient with microscopic polyangiitis complicated by cerebrovascular disease. J Stroke Cerebrovasc Dis, 2011

Ando M, Yamashiro K, Noda K, Okuma Y. Aquaporin-4 autoimmunity can cause exclusive brain tumefactive lesions. Intern Med 50:2437-2438, 2011

Morita A, Okuma Y, Kamei S, Yoshii F, Yamamoto T, Hashimoto S, Utsumi H, Hatano T, Hattori N, Matsumura M, Takahashi K, Nogawa S, Watanabe Y, Miyamoto T, Miyamoto M, Hirata K. Pramipexole reduces the prevalence of fatigue in patients with Parkinson's disease. Intern Med 50:2163-2168, 2011.

Yamashiro K, Tanaka R, Nishioka K, Ueno Y, Shimura H, Hattori N, Okuma Y, Urabe T. Cerebral infarcts associated with adenomyosis among middle-aged women. J Stroke Cerebrovasc Dis, 2011

Yamashiro K, Furuya T, Noda K, Urabe T, Hattori N, Okuma Y. Convulsive movements in bilateral paramedian thalamic and midbrain infarction. Case Rep Neurol 3:289-293, 2011

Yoshida T, Sasaki M, Yoshida M, Namekawa M, Okamoto Y, Tsujino S, Sasayama H, Mizuta I, Nakagawa M; Alexander Disease Study Group in Japan (Y Okuma is a member of this study group). Nationwide survey of Alexander disease in Japan and proposed new guidelines for diagnosis. J Neurol 258:1998-2008,2011.

＜英文著書＞

Okuma Y, Mizuno Y. Electrophysiology and other auxiliary investigations. In Cognitive impairment and dementia in Parkinson’s disease. 2nd edition. Ed. by Emre M. Oxford University Press, Oxford, UK, 153-162, 2015

Okuma Y, Mizuno Y. Electrophysiology and other auxiliary investigations. In Dementia in Parkinson’s Disease. Ed. by Emre M. Oxford University Press, Oxford, UK, 2010

＜英文総説＞

Silva de Lima AL, 他５名, Okuma Y, Bloem BR, Faber MJ. Freezing of gait and fall detection in Parkinson's disease using wearable sensors: a systematic review. J Neurol. 2017 doi: 10.1007/s00415-017-8424-0. [Epub ahead of print]

Okuma Y. Practical approach to freezing of gait in Parkinson’s disease. Pract Neurol 14:222-230, 2014

Okuma Y. Freezing of gait and falls in Parkinson’s disease. J Parkinson’s disease 4:255-260, 2014

Okuma Y, Yanagisawa N. The clinical spectrum of freezing of gait in Parkinson’s disease. Mov Disord 23(Suppl 2) :S426-430, 2008

Okuma Y. Freezing of gait in Parkinson’s disease. J Neurol 253 (suppl 7) :vii27-vii32, 2006

＜和文著書・テキスト＞

大熊泰之. 機能性歩行障害.　機能性神経障害診療ハンドブック.　下畑享良編著　中外医学社　2024, pp256-267

大熊泰之. すくみ足.　パーキンソン病の理学療法.　奈良　勲監修、松尾善美、石井光昭編、医歯薬出版　2020、pp 41-54.

大熊泰之. 歩行障害.　神経症候学と神経診断学 – AIは味方か敵か？ - Clinical Neuroscience 38:1453-1456, 2020

大熊泰之. パーキンソン病のすくみ足と転倒. パーキンソン病200年 – James Parkinsonの夢 -. 山本光利編、中外医学社、2019年、pp158-161

大熊泰之. すくみ足はどのように治療したらよいでしょうか？抗パーキンソン病薬で増悪するすくみ足もありますか？　神経内科clinical questions and pearls: パーキンソン病. 鈴木則宏監修、服部信孝、下　泰司、波田野　琢編、中外医学社　2019, pp243-247

大熊泰之. パーキンソン病の歩行障害の特徴. パーキンソン病のリハビリテーョン. 林　明人編、日本医事新報　2018, pp47-52

大熊泰之．第３章症候から鑑別診断へ．てんかん．神経内科ハンドブック第５版，水野美邦編集，医学書院，東京，2016

大熊泰之．第４章神経学的検査法．生理学的検査．神経内科ハンドブック第５版，水野美邦編集，医学書院，東京，2016

大熊泰之．第５章診断と治療．脊椎疾患．神経内科ハンドブック第５版，水野美邦編集，医学書院，東京，2016

大熊泰之．転倒（歩行障害）．パーキンソン病・パーキンソン症候群の在宅ケア．佐藤猛，服部信孝，村田美穂編，中央法規，東京，2016, pp132-138.

大熊泰之．セクションIII．神経症候の診かた. 23.異常姿勢の診かた．臨床神経内科学改訂６版．平山恵造監修，廣瀬源二郎，田代邦雄，葛原茂樹編集，南山堂，東京，2016, pp237-241

大熊泰之．セクションIII．神経症候の診かた. 24.起立・歩行障害の診かた．臨床神経内科学改訂６版．平山恵造監修，廣瀬源二郎，田代邦雄，葛原茂樹編集，南山堂，東京，2016, pp242-250

河尻澄宏，大熊泰之.進行性核上性麻痺，皮質基底核変性症．神経疾患最新の治療2015-2017. p156-158. 南江堂 2015.

大熊泰之．進行期治療をどうするか？（運動合併症の対処，姿勢異常，すくみ，転倒への対処）．インフォームドコンセントのための図説シリーズ：パーキンソン病．武田篤編，医薬ジャーナル社，2013, pp64-73.

大熊泰之．パーキンソン病のすくみ足ってどんな症状なの？ jmedあなたも名医．ここを押さえる，パーキンソン病診療．服部信孝編，日本医事新報社2012. P45-50.

大熊泰之．パーキンソン病治療における抗コリン薬の位置づけは？ jmedあなたも名医．ここを押さえる，パーキンソン病診療．日本医事新報社2012. P73-76.
塩月寛美，大熊泰之．変性疾患　—パーキンソン病を中心として−．神経救急・集中治療ハンドブック2012

大垣光太郎，大熊泰之．歩行障害　−責任病巣はどこか−．すべての内科医が知っておきたい神経疾患の診かた考え方とその対応．大生定義編，羊土社 2012 pp77

大熊泰之．パーキンソン病の転倒防止と寝たきり予防．GP・レジデントのためのパーキンソン病テキストブック．山本光利編，アルタ出版 2012. p218-227

大熊泰之．すくみ足．パーキンソン病の理学療法．奈良勲，松尾善美編．医歯薬出版，東京，37-47, 2011

波田野　琢，波田野靖子，大熊泰之：パーキンソニズムと紛らわしい症状．よくわかるパーキンソン病のすべて．水野美邦，近藤智善編．永井書店，大阪，347-358, 2011

大熊泰之：パーキンソン病の病態生理．よくわかるパーキンソン病のすべて．水野美邦，近藤智善編．永井書店，大阪，389-401, 2011

大熊泰之．第３章症候から鑑別診断へ．てんかん．神経内科ハンドブック第４版，水野美邦編集，医学書院，東京，2010, pp187-213

大熊泰之．第４章神経学的検査法．生理学的検査．神経内科ハンドブック第４版，水野美邦編集，医学書院，東京，2010, pp457-500

大熊泰之．第５章診断と治療．脊椎疾患．神経内科ハンドブック第４版，水野美邦編集，医学書院，東京，2010, pp1012-1026

大熊泰之：パーキンソン病におけるアパシーの臨床症状と評価．Parkinson’s Disease 2010. 山本光利編．アルタ出版．2010, pp102-111.

大熊泰之：minipolymyoclonusについて．パーキンソン病診療Q&A.水野美邦編．中外医学社．2009.pp 7-9.

大熊泰之：パーキンソン病治療における抗コリン薬の位置づけは？．服部信孝編．日本医事新報社．2009.pp 57-60.

大熊泰之：熱性けいれん．疾患と薬物治療．知っておきたいcommon disease 101. 富野康日己，望月正隆編．医歯薬出版．2008, pp290-292.

大熊泰之：Dopamine agonists. EBMのコンセプトを取り入れたパーキンソン病ハンドブック（改訂2版）. 水野美邦編. 中外医学社，東京, 2007, pp117-141

＜研究助成金等＞

車椅子上の足底接地の条件に着目した誤嚥防止に有効な座位姿勢の解明（分担研究者）.日本学術振興会科学研究費補助金. 基盤研究(C). 2023年度 - 2026年度.

LCIG療法を受ける進行期パーキンソン病患者の在宅療養を支える看護の構築（分担研究者）.日本学術振興会科学研究費補助金.　基盤研究(C). 2021年度 - 2023年度.

重度嗅覚障害を呈するパーキンソン病を対象としたドネペジルの予後改善効果に関する研究（分担研究者）. 厚生労働科学研究費補助金→国立研究開発法人日本医療研究開発機構（AMED）臨床研究・治験推進研究事業 2012年度-2016年度.

独立成分解析による脳死判定のための脳波信号処理（分担研究者）.日本学術振興会科学研究費補助金. 基盤研究(B) 2000年度-2001年度.

A型ボツリヌス菌毒素の筋肉内限局投与法による不随意運動の治療（研究代表者）. 日本学術振興会科学研究費補助金. 奨励研究(A)　1991年度.

研究者

教育活動

【学校法人順天堂】研究者情報データベース

研究業績詳細

大熊 泰之（オオクマ ヤスユキ）

大熊泰之（オオクマヤスユキ）