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研究業績詳細

ニヨンサバフランソワ（ニヨンサバフランソワ）

研究テーマ	殺菌物質の免疫担当細胞や炎症性細胞に及ぼす影響
研究業績（論文）	1.長岡功, Niyonsaba F, 石井(堤)裕子. Defensin. Surgery Frontier 7: 293-296, 2000 2.長岡功, 石井(堤)裕子, Niyonsaba F. Defensinの感染防御と免疫応答における役割. 臨床免疫 33: 557-565, 2000. 3.Niyonsaba F, 平田陸正, 長岡功. 殺菌ペプチドの肥満細胞に及ぼす影響. 炎症・再生 21: 109-115, 2001. 4.石井(堤)裕子, Niyonsaba F, 長岡功. 殺菌ペプチドdefensinとcathelicidinの生体防御における役割. 感染炎症免疫 31: 326-329, 2001. 5.長岡功, Niyonsaba F. デフェンシンのマスト細胞刺激作用. 臨床免疫 36: 290-296, 2001. 6.Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I. Evaluation of the effects of peptide antibiotics human -defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells. Eur J Immunol 31: 1066-1075, 2001, 7.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D. Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF- by blocking the binding of LPS to CD14+ cells. J Immunol 167: 3329-3338, 2001, 8.Niyonsaba F, Iwabuchi K, Matsuda H, Ogawa H, Nagaoka I. Epithelial cell-derived human -defensin-2 acts as chemotaxin for mast cells through pertussis toxin-sensitive and phospholipase C-dependent pathway. Int Immunol 14: 421-426, 2002, 9.Niyonsaba F, Iwabuchi K, Someya A, Hirata M, Matsuda H, Ogawa H, Nagaoka I. A cathelicidin family of human antibacterial peptide LL-37 induces mast cells chemotaxis. Immunology 106: 20-26, 2002, 10.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Tanaka S, Heumann D. Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol 9: 972-982, 2002, 11.長岡功, 廣田聡子, Niyonsaba F, 田村弘志, 田中重則, 平田陸正. Cathelicidinファミリーの殺菌ペプチドLL-37, CAP11のLPS中和作用. 炎症・再生 22: 131-138, 2002 12.Niyonsaba F, Hirata M, Ogawa H, Nagaoka I. Epithelial cell-derived antibacterial peptides human β-defensins and cathelicidin: multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy 2: 224-231, 2003. (Discontinued) 13.Niyonsaba F, Ogawa H, Nagaoka I. Human -defensin-2 functions as a chemotactic agent for tumour necrosis factor--treated human neutrophils. Immunology 111: 273-281, 2004, 14.Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. The effect of antibacterial peptide human -defensin-2 on interleukin-18 secretion by keratinocytes. J Dermatol Sci 37: 188-191, 2005, 15.Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Synergistic effect of antibacterial agents human -defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci 40: 123-132, 2005, 16.Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H. The human -defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 kinase and ERK MAPK activation in primary human keratinocytes. J Immunol 175: 1776-1784, 2005, 17.Niyonsaba F, Ogawa H. Protective roles of the skin against infection: Implication of naturally occurring human antibacterial agents -defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci 40: 157-168, 2005. 18.Niyonsaba F. Defensive properties of the skin against infection: Implication of antibacterial agents human -defensins, cathelicidin and lysozyme. 難治性皮膚疾患の病態と治療：皮膚の感染防御機構．小川秀興　編集, 吉川出版, 東京, 252-259, 2005 19.Yokoi H, Okayama Y, Niyonsaba F, Fujimori M, Enomoto F, Yoshikawa H, Ikeda K, Saito H. Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors. Allergy Asthma Proc 27: 415-421, 2006, 20.Niyonsaba F, Nagaoka I, Ogawa H. Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit Rev Immunol 26: 545-576, 2006. 21.Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci 43: 63-66, 2006, 22.Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H. Antimicrobial peptides human -defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 127: 594-604, 2007, 23.Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Antimicrobial peptides human -defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol 37: 434-444, 2007, 24.Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana STM, Ikeda S, Okumura K, Ogawa H. The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4. J Leukoc Biol 82: 657-665, 2007, 25.Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human -defensins from neutrophils. Br J Dermatol 157: 1124-1131, 2007, 26.Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H. Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol 146: 27-35, 2007, 27.長岡　功, Niyonsaba F. 抗菌ペプチドとその作用メカニズム.　臨床検査 51: 1037-1045, 2007. 28.Jayawardana ST, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H. Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun 365: 137-142, 2008, 29.Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H. Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology 124: 357-367, 2008, 30.Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M. Evaluation of the effect of human -defensins on neutrophil apoptosis. Int Immunol 20: 543-553, 2008, 31.Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, Yamamoto Y, Tadokoro T, Okumura K, Ogawa H. Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro. J Med Food 11: 14-20, 2008, 32.Niyonsaba F, Hattori F, Maeyama K, Ogawa H, Okamoto K. Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes. J Dermatol Sci 52: 216-219, 2008, 33.Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K. The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol 160: 243-249, 2009, 34.Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K. Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo. Phytother Res 23: 1581-1586, 2009, 35.Niyonsaba F, Nagaoka I, Ogawa H, Okumura K. Multifunctional antimicrobial proteins and peptides: Natural activators of immune systems. Curr Pharm Des 15: 2393-2413, 2009. 36.Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K. Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun 391: 471-476, 2010, 37.Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human -defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells. J Immunol 184: 3526-3534, 2010, 38.Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M. Evaluation of the effect of -defensins human neutrophil peptides on neutrophil apoptosis. Int J Mol Med 26: 925-934, 2010, 39.Aung G, Niyonsaba F, Ushio H, Hoq MI, Ikeda S, Ogawa H, Okumura K. A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases.J Dermatol Sci 61: 142-144, 2011, 40.Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K. Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology 132: 527-539, 2011, 41.Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H. Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol 127: 1267-1276, 2011, 42.Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S. Viral infection induces thymic stromal lymphopoietin (TSLP) in human keratinocytes. J Dermatol Sci 62: 131-134, 2011, 43.Aung G, Niyonsaba F, Ushio H, Ikeda S, Okumura K, Ogawa H. Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-kB activation. J Dermatol Sci 63: 128-131, 2011, 44.Hoq MI, Niyonsaba F, Ushio H, Aung G, Okumura K, Ogawa H. Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes. J Dermatol Sci 64: 108-118, 2011, 45.Baba Y, Maeda K, Yashiro T, Inage E, Niyonsaba F, Hara M, Suzuki R, Ohtsuka Y, Shimizu T, Ogawa H, Okumura K, Nishiyama C. Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter. Allergol Int 61: 461-467, 2012, 46.Baba Y, Maeda K, Yashiro T, Inage E, Kasakura K, Suzuki R, Niyonsaba F, Hara M, Tanabe A, Ogawa H, Okumura K, Ohtsuka Y, Shimizu T, Nishiyama C. GATA2 is critical transactivator for human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. J Biol Chem 287: 32689-32696, 2012, 47.Nguyen TT, Niyonsaba F, Ushio H, Akiyama T, Kiatsurayanon C, Smithrithee R, Ikeda S, Okumura K, Ogawa H. Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-kB. J Dermatol Sci 68: 63-66, 2012, 48.Nagaoka I, Suzuki K, Niyonsaba F, Tamura H, Hirata M. Modulation of neutrophil apoptosis by antimicrobial peptides. ISRN Microbiology 2012, 1-12, 2012. 49.Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Takeuchi M, Baba T, Hiramatsu K, Okumura K, Ogawa H. Expression and functional characterization of retinoic acid-inducible gene-I-like receptors of mast cells in response to viral infection. J Innate Immun 5: 163-173, 2013, 50.Niyonsaba F, Madera L, Okumura K, Ogawa H, Hancock REW. The innate defense regulator peptides IDR-HH2, IDR-1002 and IDR-1018 modulate human neutrophil functions. J Leukoc Biol 94: 159-170, 2013, 51.Chen X, Takai T, Xie Y, Niyonsaba F, Okumura K, Ogawa H. Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes. Biochem Biophys Res Commun 433: 532-537, 2013, 52.Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, Niyonsaba F. The antimicrobial protein S100A7/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier. Br J Dermatol 171: 742-753, 2014, 53.Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S. The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function. J Innate Immun 6: 739-753, 2014, 54.Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Okumura K, Ikeda S, Ogawa H. Host defense (antimicrobial) peptide, human -defensin-3, improves the function of the epithelial tight junction barrier in human keratinocytes. J Invest Dermatol 134: 2163-2173, 2014, 55.Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C. Critical roles for PU.1, GATA1, and GATA2 in the expression of human FcRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol 192: 3936-3946, 2014, 56.Muneza S, Nduwamariya MJ, Niyonsaba F. Incidentally detected intracranial sewing needle in a child- A case report. Interdiscip Neurosurg 2: 95-97, 2015, 57.Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H. Human b-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. J Dermatol Sci 77: 46-53, 2015, 58.Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S. Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection. Immunol Res, 61: 240-249, 2015, 59.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces semaphorin 3A expression in human epidermal keratinocytes: implications for possible application to pruritus. J Invest Dermatol 135: 2887-2890, 2015, 60.Kanazawa K, Okumura K, Ogawa H, Niyonsaba F. An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-B pathways. Immunol Res 64: 594-603, 2016, 61.Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H. Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci 83: 190-199, 2016, 62.Niyonsaba F. Novel insight into the role of antimicrobial (host defense) peptides/proteins in human skin diseases. Juntendo Med J 62: 120-131, 2016. 63.Niyonsaba F, Kiatsurayanon C, Ogawa H. The role of human β-defensins in allergic diseases. Clin Exp Allergy 46: 1522-1530, 2016. 64.ニヨンサバ　フランソワ.ヒトβ-ディフェンシン類とアレルギー性疾患.臨床免疫・アレルギー科 66: 146-151, 2016. 65.Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H. The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci 88: 117-125, 2017, 66.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human LL-37 and -defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes. J Dermatol Sci 88: 365-367, 2017, 67.Yanashima K, Chieosilapatham P, Yoshimoto E, Okumura K, Ogawa H, Niyonsaba F. Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-B-sensitive pathways. Immunol Res 65: 920-931, 2017, 68.Kiatsurayanon C, Rojanamatin J, Sudtikoonaseth P, Kampirapap K, Wichaidit M, Niyonsaba F. Unilateral linear punctate palmoplantar keratoderma: a case report. Case Rep Dermatol 9:86–89, 2017, 69.Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H. Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases. Exp Dermatol 26: 989-998, 2017 70.Chieosilapatham P, Ogawa H, Niyonsaba F. Current insights into the role of human -defensins in atopic dermatitis. Clin Exp Immunol 190: 155-166, 2017. 71.ニヨンサバ　フランソワ. 抗菌ペプチドと皮膚疾患. Bio Industry 34: 44 - 52, 2017 72.Niyonsaba F.抗菌ペプチドと皮膚疾患. 抗菌ペプチドの機能解明と技術利用. 長岡　功　監修, シーエムシー出版, 東京, 176-183, 2017 73.Sekihara K, Saitoh K, Yang H, Kawashima H, Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Niyonsaba F, Sasai K, Tabe Y. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLoS One 13: e0205581, 2018, 74.Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I. MrgX2‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells. Mol Med Rep 18: 4951-4959, 2018, 75.Kiatsurayanon C, Ogawa H, Niyonsaba F. The role of host defense peptide human -defensins in the maintenance of skin barriers. Curr Pharm Des 24: 1079-1091, 2018. .Chieosilapatham P, Ikeda S, Ogawa H, Niyonsaba F. Tissue-specific regulation of innate immune responses by human cathelicidin LL-37. Curr Pharm Des 24: 1092-1099, 2018 76.Niyonsaba F, Song P, Yue H, Sutthammikorn N, Umehara Y, Okumura K, Ogawa H. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X2. Allergy 75:203-207, 2020. 77.Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K. Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10:4360, 2020. 78.Chieosilapatham P, Yue H, Ikeda S, Ogawa H, Niyonsaba F. Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts. J Dermatol Sci 99:158-167, 2020. 79.Niyonsaba F, Takahashi M, Ikutama R. Novel insights into the pathophysiology of atopic dermatitis. Juntendo Med J 66: 480-486, 2020. 80.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapath P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Role of antimicrobial peptides in skin barrier repair in atopic dermatitis. Int J Mol Sci 21: 7607, 2020 81.Kiatsurayanon C, Niyonsaba F. Comorbidities in atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment. Nova Science Publishers, New York, 2020; pp.59-107 (pages: 265) 82.Peng G, Niyonsaba F. Emerging therapies for atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment. Nova Science Publishers, New York, 2020; pp.131-181 (pages: 265) 83.Sutthammikorn N, Supajatura V, Yue H, Takahashi M, Chansakaow S, Nakano N, Song P, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Topical Gynura procumbens as a novel therapeutic improves wound healing in diabetic mice. Plants (Basel) 10: 1122, 2021. 84.Nishi H, Niyonsaba F, Pelleg A, Schulman ES. Enhancement of mast cell degranulation mediated by purinergic receptors’ activation and PI3K typeδ. J Immunol 207:1001-1008, 2021. 85.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration and proliferation through the FGFR/JAK2/STAT3 signaling pathway. Front Immunol 12:712781, 2021. 86.Nakamura M, Kamiya K, Furuhata A, Ikeda K, Niyonsaba F. S100A7 co-localization and up-regulation of filaggrin in human sinonasal epithelial cells. Curr Med Sci 41:863-868, 2021. 87.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez V, Peng G, Yue H, Nguyen HLT, Niyonsaba F. Keratinocytes: innate immune cells in atopic dermatitis. Clin Exp Immunol 204: 296-309, 2021. 88.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy 51: 382-392, 2021. 89.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: Causes and treatments. Biomedicines 9: 229, 2021. 90.Umehara Y, Tominaga M, Takamori K, Niyonsaba F. The development of in vitro tools for understanding the physiology of human peripheral sensory neurons. Gene Technol 10: 164:2021. 91.ニヨンサバ　フランソワ, 高橋　美帆, 生玉　梨沙. アトピー性皮膚炎発症機序に対する新知見.臨床免疫・アレルギー科 75: 212 - 217, 2021. 92.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapath P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Implication of antimicrobial peptides in atopic Dermatitis: role in regulation of skin barrier. In Matheus R. de Lima (Ed). Recent Research Advances in Biology. Book Publisher International, 2021. eBook ISBN: 978-93-91215-35-4 93.Umehara Y, Tominaga M, Niyonsaba F, Takamori K. Approaches to generate human peripheral sensory neurons for understanding the physiology of human peripheral sensing. In Leon V. Berhardt (Ed). Advances in Medicine and Biology. Nova Science Publishers, New York, 2021; pp.131-181 (pages: 265) 94.Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen 30:232-224, 2022. 95.Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol 87:714-715, 2022. 96.Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. A pancancer analysis of the oncogenic role of S100 calcium binding protein A7 (S100A7) in human tumors. Biology (Basel) 11:284, 2022. 97.Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Candidalysin, a virulence factor of Candida albicans, drives mast cell accumulation and activation. J Clin Immunol 42:1009-1025, 2022. 98.Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest 132:e156501, 2022. 99.Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol 36:e1030-e1033, 2022. 100.Umehara Y, Takahashi M, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. The antimicrobial peptides human β-defensins induce the secretion of angiogenin in human dermal fibroblasts. Int J Mol Sci 23:8800, 2022. 101.Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and clinical evidence suggests that treatment with betacellulin can alleviate Th2-type cytokine-mediated impairment of skin barrier function. Int J Mol Sci 23:11520, 2022. 102.Niyonsaba F. The role of neutrophils and its NETosis in autoimmunity and autoinflammation. Front Immunol 13:1035624, 2022. 103.Kiatsurayanon C, Peng G, Niyonsaba F. Opposing roles of antimicrobial peptides in skin cancers. Curr Pharm Des 28:248-258, 2022 104.Ikutama R, Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X₇, mechanistic target of rapamycin, and MAPK pathways. J Invest Dermatol 143:751-761.e7, 2023. 105.Nguyen HLT, Peng G, Trujillo-Paez JV, Yue H, Ikutama R, Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide AMP-IBP5 suppresses dermatitis-like lesions in a mouse model of atopic dermatitis through the low-density lipoprotein receptor-related protein-1 receptor. Int J Mol Sci. 24:5200, 2023. 106.Umehara Y, Trujillo-Paez JV, Yue H, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. Calcitriol, an active form of vitamin D3, mitigates skin barrier dysfunction in atopic dermatitis NC/Nga mice. Int J Mol Sci. 24:9347, 2023. 107.Wang Y, Oonishi A, Kazami A, Suminaga R, Den E, Li Z, Ono N, Niyonsaba F, Ikeda A. Illness perception accorded by language assistance in non-Japanese-speaking patients. Cureus. 15: 1-10,2023. 108.Oonishi A, Ikeda A, Niyonsaba F, Ono N. Relationship between patient-provider language discordance and the need for professional medical interpretation for international patients in Japan. Cureus. 15: 1-9, 2023. 109.Oonishi A, Wang Y, Kazami A, Suminaga R, Den E, Li Z, Niyonsaba F, Ikeda A, Ono N. Relationship between the purpose of medical visits and the use of interpreters: the need for professional medical interpretation in Japan. J Med English Educ.22: 43-49, 2023. 110.Yabushita H, Ando H, Izawa H, Tanaka N, Ikeda A, Ono N, Niyonsaba F. Situation of language use in medical consultation for international patients and need for medical interpreting. Journal of Medical English Education. 22: 11-21, 2023. 111. 鈴田佐和子, 浅井ゆかり, 何ショウ, 楊セイカ, ニヨンサバフランソワ, 野田愛, 大野直子.医療通訳者の訓練状況ならびに医療通訳訓練歴が報酬および報酬満足度、職業継続意識に与える影響に関する研究. Journal of Medical English Education.22: 3-10, 2023. 112. 田中奈美, 井澤晴佳, 安藤晴惠, 籔下紘子, ニヨンサバフランソワ, 野田愛, 大野直子.外国人患者の診療における会話理解と医療通訳ニーズの関連因子の検討.日本ヘルスコミュニケーション学会誌. 14:1-14, 2023. 113. 安藤晴惠, 井澤晴佳, 田中奈美, 籔下紘子, ニヨンサバフランソワ, 野田愛, 大野直子.言語的障壁の解決手段が外国人患者の満足度に与える影響についての調査.日本ヘルスコミュニケーション学会誌.14: 58-68, 2023. 114.楊セイカ, 浅井ゆかり, 鈴田佐和子, 何婕, 大野直子, 野田愛, ニヨンサバフランソワ.医療通訳者の雇用形態・収入への満足度と職業キャリア成熟度との関連性に関する研究.順天堂グローバル教養論集. 8: 3-12, 2023. 115.Trujillo-Paez JV, Peng G, Nguyen HLT, Nakamura M, Umehara Y, Yue H, Ikutama R, Takahashi M, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. J Dermatol Sci.114:13-23, 2024. 116.Oonishi A, Ikeda A, Niyonsaba F, Ono N. Relationship between illness perception and the need for professional medical interpretation for international patients in Japan.J Immigr Minor Health. 26:887-894, 2024. 117.Asai Y, He J, Suzuta S, Yang J, Niyonsaba F, Ono N, Ikeda A. An investigation into the prevention of turnover of medical interpreters. Juntendo Iji Zasshi. 70:289-299, 2024. 118.Denda Y, Izawa H, Wang H, Han G, Santa M, Cao Z, Niyonsaba F, Noda A, Hara K, Ono N. Communication skills and illness perception among non-Japanese-speaking patients in Japan. Cureus. 16:e75403, 2024. 119.Peng G, Zhao W, Abudouwanli A, Sun Q, Yang M, Wang S, Tan Y, Ikeda A, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Improvement of atopic dermatitis-like symptoms in a murine model via the chromogranin A-derived peptide catestatin. Allergol Int. 21:S1323-8930, 2025. 120.Ikeda A, Peng G, Zhao W, Abudouwanli A, Ikeda S, Niyonsaba F, Suzuki Y. Impact of atopic dermatitis on renal dysfunction: insights from patient data and animal models. Front Immunol. 16:1558596, 2025. 121.Tanabe Y, Kamachi F, Ito J, Harada N, Harada S, Makino F, Abe Y, Nakano N, Izawa K, Niyonsaba F, Nishiyama C, Kitaura J, Okumura K, Takahashi K, Akiba H, Miyake S. TIM-4 regulates allergic airway inflammation and mast cell activation by binding to CD300b. J Asthma Allergy. 18:1477-1492, 2025. 122.Abudouwanli A, Peng G, Yang M, Zhao W, Sun Q, Wang S, Tan Y, Ikeda A, Ogawa H, Okumura K, Niyonsaba F. AMP-IBP5: A Multifunctional antimicrobial peptide for advanced wound healing and inflammatory skin disorders. J Funct Biomater 16:174, 2025. 123.Yang M, Peng G, Abudouwanli A, Wang S, Sun Q, Zhao W, Tan Y, Du X, Zhang L, Ogawa H, Okumura K, Gao X, Niyonsaba F. Immunopharmacological potential of Arctium lappa L. in immune-mediated skin diseases: A critical review of experimental and clinical evidence. Front Pharmacol. 16:1660352, 2025 124.Zhang L, Peng G, Wang M, Niyonsaba F, Gao X. Beyond the blockade: unmet needs in systemic targeted atopic dermatitis therapy. Front Immunol. 16:1712757, 2025. 125.Wang S, Peng G, Abudouwanli A, Yang M, Sun Q, Zhao W, Ogawa H, Okumura K, Niyonsaba F. The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis. Allergol Int. 75:42-51, 2026. 126.Peng G, Abudouwanli A, Sun Q, Tan Y, Zhao W, Yang M, Wang S, Ogawa H, Okumura K, Niyonsaba F. Role of antimicrobial peptides in the pathogenesis of atopic dermatitis. J Dermatol. 2025 (In press) 127.彭戈, ニヨンサバ　フランソワ. アトピー性皮膚炎における皮膚バリア機能およびオートファジーの活性化に対する抗菌ペプチド/宿主防御ペプチドの役割. アレルギー 74: 149―158， 2025. 128.Abudouwanli A, Peng G, Zhao W, Sun Q, Yang M, Tan Y, Ogawa H, Okumura K, Niyonsaba F. Betacellulin, a member of the EGF family, ameliorates atopic dermatitis-like symptoms via EGFR-JNK/ERK-mediated activation of autophagy. Allergol Int. 2026 (In press). 129.Peng G, Hattori F, Ogawa H, Okumura K, Niyonsaba F. Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging. NPJ Aging, 2026 (In press)

研究テーマ

殺菌物質の免疫担当細胞や炎症性細胞に及ぼす影響

研究業績（論文）

1.長岡功, Niyonsaba F, 石井(堤)裕子. Defensin. Surgery Frontier 7: 293-296, 2000
2.長岡功, 石井(堤)裕子, Niyonsaba F. Defensinの感染防御と免疫応答における役割. 臨床免疫 33: 557-565, 2000.
3.Niyonsaba F, 平田陸正, 長岡功. 殺菌ペプチドの肥満細胞に及ぼす影響. 炎症・再生 21: 109-115, 2001.
4.石井(堤)裕子, Niyonsaba F, 長岡功. 殺菌ペプチドdefensinとcathelicidinの生体防御における役割. 感染炎症免疫 31: 326-329, 2001.
5.長岡功, Niyonsaba F. デフェンシンのマスト細胞刺激作用. 臨床免疫 36: 290-296, 2001.
6.Niyonsaba F, Someya A, Hirata M, Ogawa H, Nagaoka I. Evaluation of the effects of peptide antibiotics human -defensins-1/-2 and LL-37 on histamine release and prostaglandin D2 production from mast cells. Eur J Immunol 31: 1066-1075, 2001,
7.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Heumann D. Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF- by blocking the binding of LPS to CD14+ cells. J Immunol 167: 3329-3338, 2001,
8.Niyonsaba F, Iwabuchi K, Matsuda H, Ogawa H, Nagaoka I. Epithelial cell-derived human -defensin-2 acts as chemotaxin for mast cells through pertussis toxin-sensitive and phospholipase C-dependent pathway. Int Immunol 14: 421-426, 2002,
9.Niyonsaba F, Iwabuchi K, Someya A, Hirata M, Matsuda H, Ogawa H, Nagaoka I. A cathelicidin family of human antibacterial peptide LL-37 induces mast cells chemotaxis. Immunology 106: 20-26, 2002,
10.Nagaoka I, Hirota S, Niyonsaba F, Hirata M, Adachi Y, Tamura H, Tanaka S, Heumann D. Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues. Clin Diagn Lab Immunol 9: 972-982, 2002,
11.長岡功, 廣田聡子, Niyonsaba F, 田村弘志, 田中重則, 平田陸正. Cathelicidinファミリーの殺菌ペプチドLL-37, CAP11のLPS中和作用. 炎症・再生 22: 131-138, 2002
12.Niyonsaba F, Hirata M, Ogawa H, Nagaoka I. Epithelial cell-derived antibacterial peptides human β-defensins and cathelicidin: multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy 2: 224-231, 2003. (Discontinued)
13.Niyonsaba F, Ogawa H, Nagaoka I. Human -defensin-2 functions as a chemotactic agent for tumour necrosis factor--treated human neutrophils. Immunology 111: 273-281, 2004,
14.Sampanthanarak P, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. The effect of antibacterial peptide human -defensin-2 on interleukin-18 secretion by keratinocytes. J Dermatol Sci 37: 188-191, 2005,
15.Chen X, Niyonsaba F, Ushio H, Okuda D, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Synergistic effect of antibacterial agents human -defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli. J Dermatol Sci 40: 123-132, 2005,
16.Niyonsaba F, Ushio H, Nagaoka I, Okumura K, Ogawa H. The human -defensins (-1, -2, -3, -4) and cathelicidin LL-37 induce IL-18 secretion through p38 kinase and ERK MAPK activation in primary human keratinocytes. J Immunol 175: 1776-1784, 2005,
17.Niyonsaba F, Ogawa H. Protective roles of the skin against infection: Implication of naturally occurring human antibacterial agents -defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci 40: 157-168, 2005.
18.Niyonsaba F. Defensive properties of the skin against infection: Implication of antibacterial agents human -defensins, cathelicidin and lysozyme. 難治性皮膚疾患の病態と治療：皮膚の感染防御機構．小川秀興　編集, 吉川出版, 東京, 252-259, 2005
19.Yokoi H, Okayama Y, Niyonsaba F, Fujimori M, Enomoto F, Yoshikawa H, Ikeda K, Saito H. Comparison of human tonsillar mast cell localization and ultrastructural observations between IgE-mediated allergic and non-allergic donors. Allergy Asthma Proc 27: 415-421, 2006,
20.Niyonsaba F, Nagaoka I, Ogawa H. Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit Rev Immunol 26: 545-576, 2006.
21.Chen X, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Human cathelicidin LL-37 increases vascular permeability in the skin via mast cell activation, and phosphorylates MAP kinases p38 and ERK in mast cells. J Dermatol Sci 43: 63-66, 2006,
22.Niyonsaba F, Ushio H, Nakano N, Ng W, Sayama K, Hashimoto K, Nagaoka I, Okumura K, Ogawa H. Antimicrobial peptides human -defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 127: 594-604, 2007,
23.Chen X, Niyonsaba F, Ushio H, Hara M, Yokoi H, Matsumoto K, Saito H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Antimicrobial peptides human -defensin (hBD)-3 and hBD-4 activate mast cells and increase skin vascular permeability. Eur J Immunol 37: 434-444, 2007,
24.Gondokaryono SP, Ushio H, Niyonsaba F, Hara M, Takenaka H, Jayawardana STM, Ikeda S, Okumura K, Ogawa H. The extra domain A of fibronectin stimulates murine mast cells via toll-like receptor 4. J Leukoc Biol 82: 657-665, 2007,
25.Zheng Y, Niyonsaba F, Ushio H, Nagaoka I, Ikeda S, Okumura K, Ogawa H. Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human -defensins from neutrophils. Br J Dermatol 157: 1124-1131, 2007,
26.Ogawa T, Takai T, Kato T, Kikuchi Y, Niyonsaba F, Ikeda S, Okumura K, Ogawa H. Upregulation of the release of granulocyte-macrophage colony-stimulating factor from keratinocytes stimulated with cysteine protease activity of recombinant major mite allergens, Der f 1 and Der p 1. Int Arch Allergy Immunol 146: 27-35, 2007,
27.長岡　功, Niyonsaba F. 抗菌ペプチドとその作用メカニズム.　臨床検査 51: 1037-1045, 2007.
28.Jayawardana ST, Ushio H, Niyonsaba F, Gondokaryono SP, Takenaka H, Ikeda S, Okumura K, Ogawa H. Monomeric IgE and lipopolysaccharide synergistically prevent mast-cell apoptosis. Biochem Biophys Res Commun 365: 137-142, 2008,
29.Zheng Y, Niyonsaba F, Ushio H, Ikeda S, Nagaoka I, Okumura K, Ogawa H. Microbicidal protein psoriasin is a multifunctional modulator of neutrophil activation. Immunology 124: 357-367, 2008,
30.Nagaoka I, Niyonsaba F, Tsutsumi-Ishii Y, Tamura H, Hirata M. Evaluation of the effect of human -defensins on neutrophil apoptosis. Int Immunol 20: 543-553, 2008,
31.Ishikawa Y, Tokura T, Nakano N, Hara M, Niyonsaba F, Ushio H, Yamamoto Y, Tadokoro T, Okumura K, Ogawa H. Inhibitory effect of honeybee-collected pollen on mast cell degranulation in vivo and in vitro. J Med Food 11: 14-20, 2008,
32.Niyonsaba F, Hattori F, Maeyama K, Ogawa H, Okamoto K. Induction of a microbicidal protein psoriasin (S100A7), and its stimulatory effects on normal human keratinocytes. J Dermatol Sci 52: 216-219, 2008,
33.Niyonsaba F, Suzuki A, Ushio H, Nagaoka I, Ogawa H, Okumura K. The human antimicrobial peptide dermcidin activates normal human keratinocytes. Br J Dermatol 160: 243-249, 2009,
34.Ishikawa Y, Tokura T, Ushio H, Niyonsaba F, Yamamoto Y, Tadokoro T, Ogawa H, Okumura K. Lipid-soluble components of honeybee-collected pollen exert antiallergic effect by inhibiting IgE-mediated mast cell activation in vivo. Phytother Res 23: 1581-1586, 2009,
35.Niyonsaba F, Nagaoka I, Ogawa H, Okumura K. Multifunctional antimicrobial proteins and peptides: Natural activators of immune systems. Curr Pharm Des 15: 2393-2413, 2009.
36.Takenaka H, Ushio H, Niyonsaba F, Jayawardana ST, Hajime S, Ikeda S, Ogawa H, Okumura K. Synergistic augmentation of inflammatory cytokine productions from murine mast cells by monomeric IgE and toll-like receptor ligands. Biochem Biophys Res Commun 391: 471-476, 2010,
37.Niyonsaba F, Ushio H, Hara M, Yokoi H, Tominaga M, Takamori K, Kajiwara N, Saito H, Nagaoka I, Ogawa H, Okumura K. Antimicrobial peptides human -defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine interleukin-31 by human mast cells. J Immunol 184: 3526-3534, 2010,
38.Nagaoka I, Suzuki K, Murakami T, Niyonsaba F, Tamura H, Hirata M. Evaluation of the effect of -defensins human neutrophil peptides on neutrophil apoptosis. Int J Mol Med 26: 925-934, 2010,
39.Aung G, Niyonsaba F, Ushio H, Hoq MI, Ikeda S, Ogawa H, Okumura K. A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases.J Dermatol Sci 61: 142-144, 2011,
40.Aung G, Niyonsaba F, Ushio H, Kajiwara N, Saito H, Ikeda S, Ogawa H, Okumura K. Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology 132: 527-539, 2011,
41.Ushio H, Ueno T, Kojima Y, Komatsu M, Tanaka S, Yamamoto A, Ichimura Y, Ezaki J, Nishida K, Komazawa-Sakon S, Niyonsaba F, Ishii T, Yanagawa T, Kominami E, Ogawa H, Okumura K, Nakano H. Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol 127: 1267-1276, 2011,
42.Kawasaki J, Ushio H, Kinoshita H, Fukai T, Niyonsaba F, Takai T, Ogawa H, Okumura K, Ikeda S. Viral infection induces thymic stromal lymphopoietin (TSLP) in human keratinocytes. J Dermatol Sci 62: 131-134, 2011,
43.Aung G, Niyonsaba F, Ushio H, Ikeda S, Okumura K, Ogawa H. Elafin and secretory leukocyte protease inhibitor stimulate the production of cytokines and chemokines by human keratinocytes via MAPK/ERK and NF-kB activation. J Dermatol Sci 63: 128-131, 2011,
44.Hoq MI, Niyonsaba F, Ushio H, Aung G, Okumura K, Ogawa H. Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes. J Dermatol Sci 64: 108-118, 2011,
45.Baba Y, Maeda K, Yashiro T, Inage E, Niyonsaba F, Hara M, Suzuki R, Ohtsuka Y, Shimizu T, Ogawa H, Okumura K, Nishiyama C. Involvement of PU.1 in mast cell/basophil-specific function of the human IL1RL1/ST2 promoter. Allergol Int 61: 461-467, 2012,
46.Baba Y, Maeda K, Yashiro T, Inage E, Kasakura K, Suzuki R, Niyonsaba F, Hara M, Tanabe A, Ogawa H, Okumura K, Ohtsuka Y, Shimizu T, Nishiyama C. GATA2 is critical transactivator for human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. J Biol Chem 287: 32689-32696, 2012,
47.Nguyen TT, Niyonsaba F, Ushio H, Akiyama T, Kiatsurayanon C, Smithrithee R, Ikeda S, Okumura K, Ogawa H. Interleukin-36 cytokines enhance the production of host defense peptides psoriasin and LL-37 by human keratinocytes through activation of MAPKs and NF-kB. J Dermatol Sci 68: 63-66, 2012,
48.Nagaoka I, Suzuki K, Niyonsaba F, Tamura H, Hirata M. Modulation of neutrophil apoptosis by antimicrobial peptides. ISRN Microbiology 2012, 1-12, 2012.
49.Fukuda M, Ushio H, Kawasaki J, Niyonsaba F, Takeuchi M, Baba T, Hiramatsu K, Okumura K, Ogawa H. Expression and functional characterization of retinoic acid-inducible gene-I-like receptors of mast cells in response to viral infection. J Innate Immun 5: 163-173, 2013,
50.Niyonsaba F, Madera L, Okumura K, Ogawa H, Hancock REW. The innate defense regulator peptides IDR-HH2, IDR-1002 and IDR-1018 modulate human neutrophil functions. J Leukoc Biol 94: 159-170, 2013,
51.Chen X, Takai T, Xie Y, Niyonsaba F, Okumura K, Ogawa H. Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes. Biochem Biophys Res Commun 433: 532-537, 2013,
52.Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, Niyonsaba F. The antimicrobial protein S100A7/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier. Br J Dermatol 171: 742-753, 2014,
53.Akiyama T, Niyonsaba F, Kiatsurayanon C, Nguyen TT, Ushio H, Fujimura T, Ueno T, Okumura K, Ogawa H, Ikeda S. The human cathelicidin LL-37 host defense peptide upregulates tight junction-related proteins and increases human epidermal keratinocyte barrier function. J Innate Immun 6: 739-753, 2014,
54.Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Okumura K, Ikeda S, Ogawa H. Host defense (antimicrobial) peptide, human -defensin-3, improves the function of the epithelial tight junction barrier in human keratinocytes. J Invest Dermatol 134: 2163-2173, 2014,
55.Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Nishiyama C. Critical roles for PU.1, GATA1, and GATA2 in the expression of human FcRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol 192: 3936-3946, 2014,
56.Muneza S, Nduwamariya MJ, Niyonsaba F. Incidentally detected intracranial sewing needle in a child- A case report. Interdiscip Neurosurg 2: 95-97, 2015,
57.Smithrithee R, Niyonsaba F, Kiatsurayanon C, Ushio H, Ikeda S, Okumura K, Ogawa H. Human b-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes. J Dermatol Sci 77: 46-53, 2015,
58.Tsutsui-Takeuchi M, Ushio H, Fukuda M, Yamada T, Niyonsaba F, Okumura K, Ogawa H, Ikeda S. Roles of retinoic acid-inducible gene-I-like receptors (RLRs), Toll-like receptor (TLR) 3 and 2'-5' oligoadenylate synthetase as viral recognition receptors on human mast cells in response to viral infection. Immunol Res, 61: 240-249, 2015,
59.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Cathelicidin LL-37 induces semaphorin 3A expression in human epidermal keratinocytes: implications for possible application to pruritus. J Invest Dermatol 135: 2887-2890, 2015,
60.Kanazawa K, Okumura K, Ogawa H, Niyonsaba F. An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-B pathways. Immunol Res 64: 594-603, 2016,
61.Kiatsurayanon C, Niyonsaba F, Chieosilapatham P, Okumura K, Ikeda S, Ogawa H. Angiogenic peptide (AG)-30/5C activates human keratinocytes to produce cytokines/chemokines and to migrate and proliferate via MrgX receptors. J Dermatol Sci 83: 190-199, 2016,
62.Niyonsaba F. Novel insight into the role of antimicrobial (host defense) peptides/proteins in human skin diseases. Juntendo Med J 62: 120-131, 2016.
63.Niyonsaba F, Kiatsurayanon C, Ogawa H. The role of human β-defensins in allergic diseases. Clin Exp Allergy 46: 1522-1530, 2016.
64.ニヨンサバ　フランソワ.ヒトβ-ディフェンシン類とアレルギー性疾患.臨床免疫・アレルギー科 66: 146-151, 2016.
65.Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H. The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci 88: 117-125, 2017,
66.Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K. Antimicrobial peptides human LL-37 and -defensin-3 modulate the expression of nerve elongation factors in human epidermal keratinocytes. J Dermatol Sci 88: 365-367, 2017,
67.Yanashima K, Chieosilapatham P, Yoshimoto E, Okumura K, Ogawa H, Niyonsaba F. Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-B-sensitive pathways. Immunol Res 65: 920-931, 2017,
68.Kiatsurayanon C, Rojanamatin J, Sudtikoonaseth P, Kampirapap K, Wichaidit M, Niyonsaba F. Unilateral linear punctate palmoplantar keratoderma: a case report. Case Rep Dermatol 9:86–89, 2017,
69.Niyonsaba F, Kiatsurayanon C, Chieosilapatham P, Ogawa H. Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases. Exp Dermatol 26: 989-998, 2017
70.Chieosilapatham P, Ogawa H, Niyonsaba F. Current insights into the role of human -defensins in atopic dermatitis. Clin Exp Immunol 190: 155-166, 2017.
71.ニヨンサバ　フランソワ. 抗菌ペプチドと皮膚疾患. Bio Industry 34: 44 - 52, 2017
72.Niyonsaba F.抗菌ペプチドと皮膚疾患. 抗菌ペプチドの機能解明と技術利用. 長岡　功　監修, シーエムシー出版, 東京, 176-183, 2017
73.Sekihara K, Saitoh K, Yang H, Kawashima H, Kazuno S, Kikkawa M, Arai H, Miida T, Hayashi N, Niyonsaba F, Sasai K, Tabe Y. Low-dose ionizing radiation exposure represses the cell cycle and protein synthesis pathways in in vitro human primary keratinocytes and U937 cell lines. PLoS One 13: e0205581, 2018,
74.Murakami T, Suzuki K, Niyonsaba F, Tada H, Reich J, Tamura H, Nagaoka I. MrgX2‑mediated internalization of LL‑37 and degranulation of human LAD2 mast cells. Mol Med Rep 18: 4951-4959, 2018,
75.Kiatsurayanon C, Ogawa H, Niyonsaba F. The role of host defense peptide human -defensins in the maintenance of skin barriers. Curr Pharm Des 24: 1079-1091, 2018.
.Chieosilapatham P, Ikeda S, Ogawa H, Niyonsaba F. Tissue-specific regulation of innate immune responses by human cathelicidin LL-37. Curr Pharm Des 24: 1092-1099, 2018
76.Niyonsaba F, Song P, Yue H, Sutthammikorn N, Umehara Y, Okumura K, Ogawa H. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X2. Allergy 75:203-207, 2020.
77.Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K. Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep. 10:4360, 2020.
78.Chieosilapatham P, Yue H, Ikeda S, Ogawa H, Niyonsaba F. Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts. J Dermatol Sci 99:158-167, 2020.
79.Niyonsaba F, Takahashi M, Ikutama R. Novel insights into the pathophysiology of atopic dermatitis. Juntendo Med J 66: 480-486, 2020.
80.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapath P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Role of antimicrobial peptides in skin barrier repair in atopic dermatitis. Int J Mol Sci 21: 7607, 2020
81.Kiatsurayanon C, Niyonsaba F. Comorbidities in atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment. Nova Science Publishers, New York, 2020; pp.59-107 (pages: 265)
82.Peng G, Niyonsaba F. Emerging therapies for atopic dermatitis. In Andreas Maur (Ed). Atopic dermatitis: from diagnosis to treatment. Nova Science Publishers, New York, 2020; pp.131-181 (pages: 265)
83.Sutthammikorn N, Supajatura V, Yue H, Takahashi M, Chansakaow S, Nakano N, Song P, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Topical Gynura procumbens as a novel therapeutic improves wound healing in diabetic mice. Plants (Basel) 10: 1122, 2021.
84.Nishi H, Niyonsaba F, Pelleg A, Schulman ES. Enhancement of mast cell degranulation mediated by purinergic receptors’ activation and PI3K typeδ. J Immunol 207:1001-1008, 2021.
85.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration and proliferation through the FGFR/JAK2/STAT3 signaling pathway. Front Immunol 12:712781, 2021.
86.Nakamura M, Kamiya K, Furuhata A, Ikeda K, Niyonsaba F. S100A7 co-localization and up-regulation of filaggrin in human sinonasal epithelial cells. Curr Med Sci 41:863-868, 2021.
87.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez V, Peng G, Yue H, Nguyen HLT, Niyonsaba F. Keratinocytes: innate immune cells in atopic dermatitis. Clin Exp Immunol 204: 296-309, 2021.
88.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy 51: 382-392, 2021.
89.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: Causes and treatments. Biomedicines 9: 229, 2021.
90.Umehara Y, Tominaga M, Takamori K, Niyonsaba F. The development of in vitro tools for understanding the physiology of human peripheral sensory neurons. Gene Technol 10: 164:2021.
91.ニヨンサバ　フランソワ, 高橋　美帆, 生玉　梨沙. アトピー性皮膚炎発症機序に対する新知見.臨床免疫・アレルギー科 75: 212 - 217, 2021.
92.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapath P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Implication of antimicrobial peptides in atopic Dermatitis: role in regulation of skin barrier. In Matheus R. de Lima (Ed). Recent Research Advances in Biology. Book Publisher International, 2021. eBook ISBN: 978-93-91215-35-4
93.Umehara Y, Tominaga M, Niyonsaba F, Takamori K. Approaches to generate human peripheral sensory neurons for understanding the physiology of human peripheral sensing. In Leon V. Berhardt (Ed). Advances in Medicine and Biology. Nova Science Publishers, New York, 2021; pp.131-181 (pages: 265)
94.Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen 30:232-224, 2022.
95.Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol 87:714-715, 2022.
96.Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. A pancancer analysis of the oncogenic role of S100 calcium binding protein A7 (S100A7) in human tumors. Biology (Basel) 11:284, 2022.
97.Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Candidalysin, a virulence factor of Candida albicans, drives mast cell accumulation and activation. J Clin Immunol 42:1009-1025, 2022.
98.Peng G, Tsukamoto S, Ikutama R, Le Thanh Nguyen H, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human-β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest 132:e156501, 2022.
99.Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol 36:e1030-e1033, 2022.
100.Umehara Y, Takahashi M, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. The antimicrobial peptides human β-defensins induce the secretion of angiogenin in human dermal fibroblasts. Int J Mol Sci 23:8800, 2022.
101.Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and clinical evidence suggests that treatment with betacellulin can alleviate Th2-type cytokine-mediated impairment of skin barrier function. Int J Mol Sci 23:11520, 2022.
102.Niyonsaba F. The role of neutrophils and its NETosis in autoimmunity and autoinflammation. Front Immunol 13:1035624, 2022.
103.Kiatsurayanon C, Peng G, Niyonsaba F. Opposing roles of antimicrobial peptides in skin cancers. Curr Pharm Des 28:248-258, 2022
104.Ikutama R, Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X₇, mechanistic target of rapamycin, and MAPK pathways. J Invest Dermatol 143:751-761.e7, 2023.
105.Nguyen HLT, Peng G, Trujillo-Paez JV, Yue H, Ikutama R, Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide AMP-IBP5 suppresses dermatitis-like lesions in a mouse model of atopic dermatitis through the low-density lipoprotein receptor-related protein-1 receptor. Int J Mol Sci. 24:5200, 2023.
106.Umehara Y, Trujillo-Paez JV, Yue H, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. Calcitriol, an active form of vitamin D3, mitigates skin barrier dysfunction in atopic dermatitis NC/Nga mice. Int J Mol Sci. 24:9347, 2023.
107.Wang Y, Oonishi A, Kazami A, Suminaga R, Den E, Li Z, Ono N, Niyonsaba F, Ikeda A. Illness perception accorded by language assistance in non-Japanese-speaking patients. Cureus. 15: 1-10,2023.
108.Oonishi A, Ikeda A, Niyonsaba F, Ono N. Relationship between patient-provider language discordance and the need for professional medical interpretation for international patients in Japan. Cureus. 15: 1-9, 2023.
109.Oonishi A, Wang Y, Kazami A, Suminaga R, Den E, Li Z, Niyonsaba F, Ikeda A, Ono N. Relationship between the purpose of medical visits and the use of interpreters: the need for professional medical interpretation in Japan. J Med English Educ.22: 43-49, 2023.
110.Yabushita H, Ando H, Izawa H, Tanaka N, Ikeda A, Ono N, Niyonsaba F. Situation of language use in medical consultation for international patients and need for medical interpreting. Journal of Medical English Education. 22: 11-21, 2023.
111. 鈴田佐和子, 浅井ゆかり, 何ショウ, 楊セイカ, ニヨンサバフランソワ, 野田愛, 大野直子.医療通訳者の訓練状況ならびに医療通訳訓練歴が報酬および報酬満足度、職業継続意識に与える影響に関する研究. Journal of Medical English Education.22: 3-10, 2023.
112. 田中奈美, 井澤晴佳, 安藤晴惠, 籔下紘子, ニヨンサバフランソワ, 野田愛, 大野直子.外国人患者の診療における会話理解と医療通訳ニーズの関連因子の検討.日本ヘルスコミュニケーション学会誌. 14:1-14, 2023.
113. 安藤晴惠, 井澤晴佳, 田中奈美, 籔下紘子, ニヨンサバフランソワ, 野田愛, 大野直子.言語的障壁の解決手段が外国人患者の満足度に与える影響についての調査.日本ヘルスコミュニケーション学会誌.14: 58-68, 2023.
114.楊セイカ, 浅井ゆかり, 鈴田佐和子, 何婕, 大野直子, 野田愛, ニヨンサバフランソワ.医療通訳者の雇用形態・収入への満足度と職業キャリア成熟度との関連性に関する研究.順天堂グローバル教養論集. 8: 3-12, 2023.
115.Trujillo-Paez JV, Peng G, Nguyen HLT, Nakamura M, Umehara Y, Yue H, Ikutama R, Takahashi M, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. J Dermatol Sci.114:13-23, 2024.
116.Oonishi A, Ikeda A, Niyonsaba F, Ono N. Relationship between illness perception and the need for professional medical interpretation for international patients in Japan.J Immigr Minor Health. 26:887-894, 2024.
117.Asai Y, He J, Suzuta S, Yang J, Niyonsaba F, Ono N, Ikeda A. An investigation into the prevention of turnover of medical interpreters. Juntendo Iji Zasshi. 70:289-299, 2024.
118.Denda Y, Izawa H, Wang H, Han G, Santa M, Cao Z, Niyonsaba F, Noda A, Hara K, Ono N. Communication skills and illness perception among non-Japanese-speaking patients in Japan. Cureus. 16:e75403, 2024.
119.Peng G, Zhao W, Abudouwanli A, Sun Q, Yang M, Wang S, Tan Y, Ikeda A, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Improvement of atopic dermatitis-like symptoms in a murine model via the chromogranin A-derived peptide catestatin. Allergol Int. 21:S1323-8930, 2025.
120.Ikeda A, Peng G, Zhao W, Abudouwanli A, Ikeda S, Niyonsaba F, Suzuki Y. Impact of atopic dermatitis on renal dysfunction: insights from patient data and animal models. Front Immunol. 16:1558596, 2025.
121.Tanabe Y, Kamachi F, Ito J, Harada N, Harada S, Makino F, Abe Y, Nakano N, Izawa K, Niyonsaba F, Nishiyama C, Kitaura J, Okumura K, Takahashi K, Akiba H, Miyake S. TIM-4 regulates allergic airway inflammation and mast cell activation by binding to CD300b. J Asthma Allergy. 18:1477-1492, 2025.
122.Abudouwanli A, Peng G, Yang M, Zhao W, Sun Q, Wang S, Tan Y, Ikeda A, Ogawa H, Okumura K, Niyonsaba F. AMP-IBP5: A Multifunctional antimicrobial peptide for advanced wound healing and inflammatory skin disorders. J Funct Biomater 16:174, 2025.
123.Yang M, Peng G, Abudouwanli A, Wang S, Sun Q, Zhao W, Tan Y, Du X, Zhang L, Ogawa H, Okumura K, Gao X, Niyonsaba F. Immunopharmacological potential of Arctium lappa L. in immune-mediated skin diseases: A critical review of experimental and clinical evidence. Front Pharmacol. 16:1660352, 2025
124.Zhang L, Peng G, Wang M, Niyonsaba F, Gao X. Beyond the blockade: unmet needs in systemic targeted atopic dermatitis therapy. Front Immunol. 16:1712757, 2025.
125.Wang S, Peng G, Abudouwanli A, Yang M, Sun Q, Zhao W, Ogawa H, Okumura K, Niyonsaba F. The interaction between the skin microbiome and antimicrobial peptides within the epidermal immune microenvironment: Bridging insights into atopic dermatitis. Allergol Int. 75:42-51, 2026.
126.Peng G, Abudouwanli A, Sun Q, Tan Y, Zhao W, Yang M, Wang S, Ogawa H, Okumura K, Niyonsaba F. Role of antimicrobial peptides in the pathogenesis of atopic dermatitis. J Dermatol. 2025 (In press)
127.彭戈, ニヨンサバ　フランソワ. アトピー性皮膚炎における皮膚バリア機能およびオートファジーの活性化に対する抗菌ペプチド/宿主防御ペプチドの役割. アレルギー 74: 149―158， 2025.
128.Abudouwanli A, Peng G, Zhao W, Sun Q, Yang M, Tan Y, Ogawa H, Okumura K, Niyonsaba F. Betacellulin, a member of the EGF family, ameliorates atopic dermatitis-like symptoms via EGFR-JNK/ERK-mediated activation of autophagy. Allergol Int. 2026 (In press).
129.Peng G, Hattori F, Ogawa H, Okumura K, Niyonsaba F. Decreased S100A7 expression is linked to altered differentiation-, autophagy- and senescence-related programs during skin aging. NPJ Aging, 2026 (In press)

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