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兒玉裕三（コダマユウゾウ）

研究テーマ	COPDの息切れと運動耐容能について
研究業績（論文）	1. Kodama Y, Setoguchi Y, Fukuchi Y: Infection of replication-deficient adenoviral vector enhances interleukin-8 production in small airway epithelial cells more than in large airway epithelial cells. Respirology 6: 271-279, 2001, IF: 3.345 2. Seyama K, Kira S, Takahashi H, Ohnishi M, Kodama Y, Dambara T, Kobayashi J, Kitamura S, Fukuchi Y: Longitudinal follow-up study of 11 patients with pulmonary lymphangioleiomyomatosis: diverse clinical courses of LAM allow some patients to be treated without anti-hormone therapy. Respirology 6: 331-340, 2001, IF: 3.345 3. Kodama Y, Baxter RC, and Martin JL: Insulin-like growth factor-I inhibits cell growth in the A549 non-small lung cancer cell line. Am. J. Respir. Cell Mol. Biol. 27: 336-344, 2002, IF: 3.985 4. Sato T, Seyama K, Sato Y, Mori H, Souma S, Akiyoshi T, Kodama Y, Mori T, Goto S, Takahashi K, Fukuchi Y, Maruyama N, Ishigami A: Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking. Am J Respir Crit Care Med. 174: 530-537, 2006, IF: 12.996/CI: 1270 5. Kodama Y, Seyama K, Yoshimi K, Ueki J, Oka H, Ikari Y and Fukuchi Y: Survey of implementation of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in nine Asian countries. Geriatr. Gerontol. Int. 7: 174-183, 2007, IF: 2.188/CI: 2 6. Mori H, Nose T, Ishitani K, Kasagi S, Souma S, Akiyoshi T, Kodama Y, Mori T, Kondo M, Sasaki S, Iwase A, Takahashi K, Fukuchi Y, Seyama K: PDE4 inhibitor (GPD-1116) markedly attenuates the development of cigarette smoke-induced emphysema in senescence accelerated mice P1 strain. Am J Physiol Lung Cell Mol Physiol 294: L196-207, 2008, IF: 4.080 7. Takagi Y, Sato T, Morio Y, Kumasaka T, Mitani K, Miyamoto H, Iwakami S, Kodama Y, Onuma E, Seyama K, Takahashi K: A pleuro-peritoneal communication through the diaphragm affected with lymphangioleiomyomatosis. Internal Medicine 49: 439-45, 2010, IF: 0.967/CI: 8 8．Tobino K, Gunji Y, Kurihara M, Kunogi M, Koike K, Tomiyama N, Johkoh T, Kodama Y, Iwakami S, Kikkawa M, Takahashi K, Seyama K：Characteristics of pulmonary cysts in Birt–Hogg–Dube syndrome: Thin-section CT findings of the chest in 12 patients Eur J Radiol. 77: 403-409, 2011, IF: 2.369/CI: 80 9. Ichikawa M, Kodama Y★ , Yoshimi Y, Shiota S, Kotajima M, Nakajyo M, Seyama K, Fukuchi1 Y, Takahashi K: Effects of transdermal tulobuterol on dyspnea and respiratory function during exercise in patients with COPD. J Thorac Dis 7: 687-696, 2015 (★equal contribution), IF: 1.783 10. Kodama Y, Kishimoto Y, Muramatsu Y, Tatebe J, Yamamoto Y, Hirota N, Itoigawa Y, Atsuta R, Koike K, Sato T, Aizawa K, Takahashi K, Morita T, Homma S, Seyama K, Ishigami A: Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome, and bronchial asthma. Clin Respir J. 11: 915-924, 2017, IF: 2.211/CI: 16 11. Kaku Y, Oh S, Suzuki K, Kodama Y, Sekiya M, Seyama K and Fukuchi Y: Impact of Airflow Limitation on Comorbidities and Postoperative Complications in Patients Undergoing Thoracic Surgery: A Retrospective Observational Study Ann Thorac Cardiovasc Surg. 22: 146-52, 2016, IF: 0.940/CI: 9 12. Ai T, Yuri M, Tabe Y, Kakimoto A, Morishita S, Tsuchiya K, Takamochi K, Kodama Y, Takahashi F, Shigeki M, Horii T, Suzuki K, Takahashi K, Miida T, Ohsaka A:　Comparison of the Analytical Performance Between cobas EGFR Assay and PCR-Clamp Method in the Detection of EGFR Mutations in Japanese Non-Small Cell Lung Cancer Patients. Clin Lab. 63: 1021-1026, 2017, IF: 0.848/CI: 1 13. Toyoki M, Hase M, Hirasawa Y, Umeyama T, Miyazaki Y, Kano R, Sugita T, Hiruma M, Kodama Y, Ikeda S: A Giant Dermatophyte Abscess Caused by Trichophyton rubrum in an Immunocompromised Patient. Med Mycol J. 58: E63-E66, 2017, IF: 2.799 14. Nishino K, Yoshimi K, Shibuya T, Hayashi T, Mitani K, Kobayashi E, Ichikawa M, Asao T, Suzuki Y, Sato T, Shiota S, Kodama Y, Takahashi K, Seyama K: Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases Intern Med. 56: 943-948, 2017, IF: 0.817 15. Suzuki Y, Sato T, Sugimoto M, Baskoro H, Karasutani K, Mitsui A, Nurwidya F, Arano N, Kodama Y, Hirano S, Ishigami A, Seyama K, Takahashi K: Biochem Biophys Res Commun. 492: 74-81, 2017, IF: 2.559 /CI: 20 16. Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K: Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis. Lung. 196: 531-541, 2018, IF: 2.101/CI: 16 17. Kato M, Kanehiro Y, Yoshimi K, Kodama Y, Sekiya M, Sato T, Takahashi K, Seyama K: COPD assessment test as a possible tool for evaluating health-related quality of life in lymphangioleiomyomatosis Respiratory Investigation 56: 480-488, 2018, IF: 0.81 18. Baskoro H, Sato T, Karasutani K, Suzuki Y, Mitsui A, Arano N, Nurwidya F, Kato M, Takahashi F, Kodama Y, Seyama K, Takahashi K: Regional heterogeneity in response of airway epithelial cells to cigarette smoke. BMC Pulmonary Medicine 18: 148, 2018, IF: 2.721 19. Kato M, Sekiya M, Suzuki Y, Sato T, Ichikawa M, Kodama Y, Seyama K, Aikawa-Hirasawa E, Takahashi K. Evaluation of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease Using an Accelerometer with Tapestry-Style Display Capability. Juntendo Medical Journal 64, 286-294, 2018, IF:　－　 20. Matsuno K, Harada N, Harada S, Takeshige T, Ishimori A, Itoigawa Y, Katsura Y, Kodama Y, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K: Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Exp Lung Res. 44:332-343, 2018, IF: 1.568/CI: 8 21. Yamaguchi Y, Shiota S, Kusunoki Y, Hamaya H, Ishii M, Kodama Y, Akishita M, Kida K, Takahashi K, Nagase T, Fukuchi Y: Polysomnographic features of low arousal threshold in overlap syndrome involving obstructive sleep apnea and chronic obstructive pulmonary disease. Sleep and Breathing 23:1095-1100, 2019, IF: 1.48 22. Kadoya K, Togo S, Tulafu M, Namba Y, Iwai M, Watanabe J, Okabe T, Jin J, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Takeda T, Kondo N, Takahashi K: Specific Features of Fibrotic Lung Fibroblasts Highly Sensitive to Fibrotic Processes Mediated via TGF-β-ERK5 Interaction. Cell Physiol Biochem. 2019; 52:822-837. IF: 5.500 23. Jin J, Togo S, Kadoya K, Tulafu M, Namba Y, Iwai M, Watanabe J, Nagahama K, Okabe T, Hidayat M, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Sasaki S, Tominaga S, Takahashi K: Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1. Respir Res. 20:119, 2019, IF: 3.829/CI: 51 24. Karasutani K, Baskoro H, Sato T, Arano N, Suzuki Y, Mitsui A, Shimada N, Kodama Y, Seyama K, Fukuchi Y, Takahashi K. Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice. Journal of Visualized Experiments. e58197 p1-7, 2019, IF: 1.108/CI: 3 25. Tsutsumi T, Nagaoka T, Yoshida T, Wang L, Kuriyama S, Suzuki Y, Nagata Y, Harada N, Kodama Y, Takahashi F, Morio Y, Takahashi K: Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation. PLoS One. 14: e0214697, 2019, IF: 2.776/CI: 26 26. Ihara H, Kikuchi K, Taniguchi H, Fujita S, Tsuruta Y, Kato M, Mitsuishi Y, Tajima K, Kodama Y, Takahashi F, Takahashi K, Azuma N: 23-valent pneumococcal polysaccharide vaccine improves survival in dialysis patients by preventing cardiac events. Vaccine 37:6447-6453, 2019, IF: 3.269/CI: 6 27. Nitta NA, Sato T, Komura M, Yoshikawa H, Suzuki Y, Mitsui A, Kuwasaki E, Takahashi F, Kodama Y, Seyama K, Takahashi K: Exposure to the heated tobacco product IQOS generates apoptosis-mediated pulmonary emphysema in murine lungs. Am J Physiol Lung Cell Mol Physiol. 322:L699-L711, 2022, IF: 5.464/CI: 4 28. Komura M, Sato T, Yoshikawa H, Nitta NA, Suzuki Y, Koike K, Kodama Y, Seyama K, Takahashi K: Propylene glycol, a component of electronic cigarette liquid, damages epithelial cells in human small airways. Respir Res. 23:216, 2022, IF:4.961 29. Komura M, Sato T, Suzuki Y, Yoshikawa H, Arano Nitta N, Hayashi M, Kuwasaki E, Horikoshi K, Nishioki T, Mori M, Kodama Y, Sasaki S, Takahashi K: Blood Eosinophil Count as a Predictive Biomarker of Chronic Obstructive Pulmonary Disease Exacerbation in a Real-World Setting. Can Respir J. 2023, 3302405, IF:2.13 30. Yoshikawa H, Sato T, Horikoshi K, Komura M, Arano Nitta N, Mitsui A, Koike K, Kodama Y, Takahashi K: miR-146a regulates emphysema formation and abnormal 3 inflammation in the lungs of two mouse models. Am J Physiol Lung Cell Mol Physiol. 2024, 326: L98–L110, IF:6.011

研究テーマ

COPDの息切れと運動耐容能について

研究業績（論文）

1. Kodama Y, Setoguchi Y, Fukuchi Y: Infection of replication-deficient adenoviral vector enhances interleukin-8 production in small airway epithelial cells more than in large airway epithelial cells. Respirology 6: 271-279, 2001, IF: 3.345

2. Seyama K, Kira S, Takahashi H, Ohnishi M, Kodama Y, Dambara T, Kobayashi J, Kitamura S, Fukuchi Y: Longitudinal follow-up study of 11 patients with pulmonary lymphangioleiomyomatosis: diverse clinical courses of LAM allow some patients to be treated without anti-hormone therapy. Respirology 6: 331-340, 2001, IF: 3.345

3. Kodama Y, Baxter RC, and Martin JL: Insulin-like growth factor-I inhibits cell growth in the A549 non-small lung cancer cell line. Am. J. Respir. Cell Mol. Biol. 27: 336-344, 2002, IF: 3.985

4. Sato T, Seyama K, Sato Y, Mori H, Souma S, Akiyoshi T, Kodama Y, Mori T, Goto S, Takahashi K, Fukuchi Y, Maruyama N, Ishigami A: Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking. Am J Respir Crit Care Med. 174: 530-537, 2006,
IF: 12.996/CI: 1270

5. Kodama Y, Seyama K, Yoshimi K, Ueki J, Oka H, Ikari Y and Fukuchi Y: Survey of implementation of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines in nine Asian countries. Geriatr. Gerontol. Int. 7: 174-183, 2007, IF: 2.188/CI: 2

6. Mori H, Nose T, Ishitani K, Kasagi S, Souma S, Akiyoshi T, Kodama Y, Mori T, Kondo M, Sasaki S, Iwase A, Takahashi K, Fukuchi Y, Seyama K: PDE4 inhibitor (GPD-1116) markedly attenuates the development of cigarette smoke-induced emphysema in senescence accelerated mice P1 strain. Am J Physiol Lung Cell Mol Physiol 294: L196-207, 2008, IF: 4.080

7. Takagi Y, Sato T, Morio Y, Kumasaka T, Mitani K, Miyamoto H, Iwakami S, Kodama Y, Onuma E, Seyama K, Takahashi K: A pleuro-peritoneal communication through the diaphragm affected with lymphangioleiomyomatosis. Internal Medicine 49: 439-45, 2010, IF: 0.967/CI: 8

8．Tobino K, Gunji Y, Kurihara M, Kunogi M, Koike K, Tomiyama N, Johkoh T, Kodama Y, Iwakami S, Kikkawa M, Takahashi K, Seyama K：Characteristics of pulmonary cysts in Birt–Hogg–Dube syndrome: Thin-section CT findings of the chest in 12 patients Eur J Radiol. 77: 403-409, 2011, IF: 2.369/CI: 80

9. Ichikawa M, Kodama Y★ , Yoshimi Y, Shiota S, Kotajima M, Nakajyo M, Seyama K, Fukuchi1 Y, Takahashi K: Effects of transdermal tulobuterol on dyspnea and respiratory function during exercise in patients with COPD. J Thorac Dis 7: 687-696, 2015 (★equal contribution), IF: 1.783

10. Kodama Y, Kishimoto Y, Muramatsu Y, Tatebe J, Yamamoto Y, Hirota N, Itoigawa Y, Atsuta R, Koike K, Sato T, Aizawa K, Takahashi K, Morita T, Homma S, Seyama K, Ishigami A: Antioxidant nutrients in plasma of Japanese patients with chronic obstructive pulmonary disease (COPD), asthma-COPD overlap syndrome, and bronchial asthma. Clin Respir J. 11: 915-924, 2017, IF: 2.211/CI: 16

11. Kaku Y, Oh S, Suzuki K, Kodama Y, Sekiya M, Seyama K and Fukuchi Y: Impact of Airflow Limitation on Comorbidities and Postoperative Complications in Patients Undergoing Thoracic Surgery: A Retrospective Observational Study Ann Thorac Cardiovasc Surg. 22: 146-52, 2016,
IF: 0.940/CI: 9

12. Ai T, Yuri M, Tabe Y, Kakimoto A, Morishita S, Tsuchiya K, Takamochi K, Kodama Y,
Takahashi F, Shigeki M, Horii T, Suzuki K, Takahashi K, Miida T, Ohsaka A:　Comparison of the Analytical Performance Between cobas EGFR Assay and PCR-Clamp Method in the Detection of EGFR Mutations in Japanese Non-Small Cell Lung Cancer Patients. Clin Lab. 63: 1021-1026, 2017, IF: 0.848/CI: 1

13. Toyoki M, Hase M, Hirasawa Y, Umeyama T, Miyazaki Y, Kano R, Sugita T, Hiruma M, Kodama Y, Ikeda S: A Giant Dermatophyte Abscess Caused by Trichophyton rubrum in an Immunocompromised Patient. Med Mycol J. 58: E63-E66, 2017, IF: 2.799

14. Nishino K, Yoshimi K, Shibuya T, Hayashi T, Mitani K, Kobayashi E, Ichikawa M, Asao T, Suzuki Y, Sato T, Shiota S, Kodama Y, Takahashi K, Seyama K: Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases Intern Med. 56: 943-948, 2017, IF: 0.817

15. Suzuki Y, Sato T, Sugimoto M, Baskoro H, Karasutani K, Mitsui A, Nurwidya F, Arano N, Kodama Y, Hirano S, Ishigami A, Seyama K, Takahashi K: Biochem Biophys Res Commun. 492: 74-81, 2017, IF: 2.559 /CI: 20

16. Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K: Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis. Lung. 196: 531-541, 2018, IF: 2.101/CI: 16

17. Kato M, Kanehiro Y, Yoshimi K, Kodama Y, Sekiya M, Sato T, Takahashi K, Seyama K: COPD assessment test as a possible tool for evaluating health-related quality of life in lymphangioleiomyomatosis Respiratory Investigation 56: 480-488, 2018, IF: 0.81

18. Baskoro H, Sato T, Karasutani K, Suzuki Y, Mitsui A, Arano N, Nurwidya F, Kato M, Takahashi F, Kodama Y, Seyama K, Takahashi K: Regional heterogeneity in response of airway epithelial cells to cigarette smoke. BMC Pulmonary Medicine 18: 148, 2018, IF: 2.721

19. Kato M, Sekiya M, Suzuki Y, Sato T, Ichikawa M, Kodama Y, Seyama K, Aikawa-Hirasawa E, Takahashi K. Evaluation of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease Using an Accelerometer with Tapestry-Style Display Capability. Juntendo Medical Journal 64, 286-294, 2018, IF:　－　

20. Matsuno K, Harada N, Harada S, Takeshige T, Ishimori A, Itoigawa Y, Katsura Y, Kodama Y, Makino F, Ito J, Kamachi F, Okumura K, Akiba H, Atsuta R, Takahashi K: Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Exp Lung Res. 44:332-343, 2018, IF: 1.568/CI: 8

21. Yamaguchi Y, Shiota S, Kusunoki Y, Hamaya H, Ishii M, Kodama Y, Akishita M, Kida K, Takahashi K, Nagase T, Fukuchi Y: Polysomnographic features of low arousal threshold in overlap syndrome involving obstructive sleep apnea and chronic obstructive pulmonary disease. Sleep and Breathing 23:1095-1100, 2019, IF: 1.48

22. Kadoya K, Togo S, Tulafu M, Namba Y, Iwai M, Watanabe J, Okabe T, Jin J, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Takeda T, Kondo N, Takahashi K: Specific Features of Fibrotic Lung Fibroblasts Highly Sensitive to Fibrotic Processes Mediated via TGF-β-ERK5 Interaction. Cell Physiol Biochem.
2019; 52:822-837. IF: 5.500

23. Jin J, Togo S, Kadoya K, Tulafu M, Namba Y, Iwai M, Watanabe J, Nagahama K, Okabe T, Hidayat M, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Sasaki S, Tominaga S, Takahashi K: Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1. Respir Res. 20:119, 2019, IF: 3.829/CI: 51

24. Karasutani K, Baskoro H, Sato T, Arano N, Suzuki Y, Mitsui A, Shimada N, Kodama Y, Seyama K, Fukuchi Y, Takahashi K. Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice. Journal of Visualized Experiments. e58197 p1-7, 2019, IF: 1.108/CI: 3

25. Tsutsumi T, Nagaoka T, Yoshida T, Wang L, Kuriyama S, Suzuki Y, Nagata Y, Harada N, Kodama Y, Takahashi F, Morio Y, Takahashi K: Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation. PLoS One. 14: e0214697, 2019, IF: 2.776/CI: 26

26. Ihara H, Kikuchi K, Taniguchi H, Fujita S, Tsuruta Y, Kato M, Mitsuishi Y, Tajima K, Kodama Y, Takahashi F, Takahashi K, Azuma N: 23-valent pneumococcal polysaccharide vaccine improves survival in dialysis patients by preventing cardiac events. Vaccine 37:6447-6453, 2019, IF: 3.269/CI: 6

27. Nitta NA, Sato T, Komura M, Yoshikawa H, Suzuki Y, Mitsui A, Kuwasaki E, Takahashi F, Kodama Y, Seyama K, Takahashi K: Exposure to the heated tobacco product IQOS generates apoptosis-mediated pulmonary emphysema in murine lungs. Am J Physiol Lung Cell Mol Physiol. 322:L699-L711, 2022, IF: 5.464/CI: 4

28. Komura M, Sato T, Yoshikawa H, Nitta NA, Suzuki Y, Koike K, Kodama Y, Seyama K, Takahashi K: Propylene glycol, a component of electronic cigarette liquid, damages epithelial cells in human small airways. Respir Res. 23:216, 2022, IF:4.961

29. Komura M, Sato T, Suzuki Y, Yoshikawa H, Arano Nitta N, Hayashi M, Kuwasaki E,
Horikoshi K, Nishioki T, Mori M, Kodama Y, Sasaki S, Takahashi K: Blood Eosinophil Count as a Predictive Biomarker of Chronic Obstructive Pulmonary Disease Exacerbation in a Real-World Setting. Can Respir J. 2023, 3302405, IF:2.13

30. Yoshikawa H, Sato T, Horikoshi K, Komura M, Arano Nitta N, Mitsui A, Koike K, Kodama Y, Takahashi K: miR-146a regulates emphysema formation and abnormal 3 inflammation in the lungs of two mouse models. Am J Physiol Lung Cell Mol Physiol. 2024, 326: L98–L110, IF:6.011

研究者

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【学校法人順天堂】研究者情報データベース

研究業績詳細

兒玉 裕三（コダマ ユウゾウ）

兒玉裕三（コダマユウゾウ）