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研究業績詳細

長岡鉄太郎（ナガオカテツタロウ）

研究テーマ	肺循環障害、呼吸器内視鏡診断・治療
研究業績（論文）	1. Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y: Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol, 2001; 127: 53-60. IF:1.900/CI:25 2. McMurtry IF, Bauer NR, Fagan KA, Nagaoka T, Gebb SA, Oka M: Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension. Adv Exp Med Biol, 2003; 543: 127-37. IF:3.650/CI:51 3. Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M: Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol, 2004; 287: L665-72. IF: 3.600/CI: 191 4. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M: Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med, 2005; 171: 494-9. IF:19.300/CI:201 5. Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M: Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn- hooded rat. J Appl Physiol, 2006; 100: 996-1002. IF:3.300/CI:78 6. Kaufman J, Sakao E, Oka M, Nagaoka T, Oliver-Picket CK, Jones PL, McMurtry IF, Gebb SA. Rho guanosine triphosphatases in lung development and pulmonary hypertension. Chest, 2005; 128: 610S. IF:9.500/CI:2 7. Oka M, Karoor V, Homma N, Nagaoka T, Sakao E, Golembeski SM, Limbird J, Imamura M, Gebb SA, Fagan KA, McMurtry IF: Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension. Cardiovasc Res, 2007; 74: 377-87. IF:10.400/CI:69 8. Morio Y, Homma N, Takahashi H, Yamamoto A, Nagaoka T, Sato K, Muramatsu M, Fukuchi Y: Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs. J Vasc Res, 2007; 44: 325-35. IF:1.800/CI:12 9. Homma N, Nagaoka T, Morio Y, Ota H, Gebb SA, Karoor V, McMurtry IF, Oka M: Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol, 2007; 50: 697-702. IF:2.600/CI: 55 10. Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M: Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol, 2008; 295: L71-8. IF: 3.600/CI: 66 11. Ochiai E, Kamei K, Watanabe A, Nagayoshi M, Tada Y, Nagaoka T, Sato K, Sato A, Shibuya K: Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. Int J Exp Pathol, 2008; 89: 201-8. IF:1.800/CI:15 12. Takahashi F, Tsuta K, Nagaoka T, Miyamoto H, Saito Y, Amano H, Uchida K, Morio Y, Shimizu K, Sasaki S, Tominaga S, Uekusa T, Izumi H, Anami Y, Matsuno Y, Takahashi K, Fukuchi Y: Successful resection of dermatomyositis associated with thymic carcinoma: report of a case. Surg Today, 2008; 38: 245-8. IF:1.700/CI:12 13. Takahashi F, Uchida K, Nagaoka T, Honma N, Cui R, Yoshioka M, Morio Y, Suzuki T, Tominaga S, Takahashi K, Fukuchi Y: Isolated congenital spleen agenesis: a rare cause of chronic thromboembolic pulmonary hypertension in an adult. Respirology, 2008; 13: 913-5. IF:6.600/CI:12 14. Sekiya M, Ishiwata T, Yoshimi K, Nagaoka T, Morio Y, Shiota S, Suzuki T, Seyama K, Takahashi K: Malignant pleurisy associated with primary lung cancer well controlled by pleurodesis using distilled water. Intern Med, 2009; 48: 1051-5. IF:1.000/CI:0 15. Takahashi F, Kumasaka T, Nagaoka T, Wakiya M, Fujii H, Shimizu K, Uchida K, Morio Y, Seyama K, Hino O, Takahashi K, Fukuchi Y: Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma. Pathol Int, 2009; 59: 752-6. IF:2.500/CI:38 16. Toba M, Nagaoka T, Morio Y, Sato K, Uchida K, Homma N, Takahashi K: Involvement of Rho kinase in the pathogenesis of acute pulmonary embolism- induced polystyrene microspheres in rats. Am J Physiol Lung Cell Mol Physiol, 2010; 298: L297-303. IF:3.600/CI:13 17. Nagahama K, Hayashi T, Nagaoka T, Kanemaru R, Togo S, Kumasaka T, Uekusa T, Seyama K, Takahashi K: Pulmonary Erdheim-Chester disease: A response to predonisolone. Respir Med CME, 2011; 4(2): 81-84. IF(-)/CI:- 18. Ohashi R, Kato M, Katsura Y, Takekawa H, Hoshika Y, Sugawara T, Yoshimi K, Togo S, Nagaoka T, Seyama K, Takahashi K, Tsuchiya K, Misawa S, Kikuchi K: Breakthrough lung Scedosporium prolificans infection with multiple cavity lesions in a patient receiving voriconazole for probable invasive aspergillosis associated with monoclonal gammopathy of undetermined significance (MGUS). Med Mycol J, 2011; 52: 33-8. IF:1.400/CI:10 19. Ando K, Motojima S, Doi T, Nagaoka T, Kaneko N, Aoshima M, Takahashi K: Effect of glucocorticoid monotherapy on pulmonary function and survival in Japanese patients with scleroderma-related interstitial lung disease. Respir Investig, 2013; 69-75. IF:2.400/CI: 24 20. Kuriyama S, Morio Y, Toba M, Nagaoka T, Takahashi F, Iwakami S, Seyama K, Takahashi K: Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system. Am J Physiol Lung Cell Mol Physiol, 2014; 306: L996-L1005. IF: 3.600/CI:29 21. Ando K, Kuraishi H, Nagaoka T, Tsutsumi T, Hoshika Y, Kimura T, Ienaga H, Morio Y, Takahashi K: Potential Role of CT Metrics in Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension. Lung, 2015; 193: 911-8. IF:4.600/CI: 10 22. Sekimoto Y, Kato M, Shukuya T, Koyama R, Nagaoka T, Takahashi K: Bevacizumab- induced chronic interstitial pneumonia during maintenance therapy in non-small cell lung cancer. Respirol Case Rep, 2016; 4(2): e00151. IF:0.800/CI:5 23. Kanemaru R, Morio Y, Takekawa H, Jo H, Kasuga F, Koyama R, Shiota S, Nagaoka T, Takahashi K: Successful treatment with weekly high-dose erlotinib against meningeal metastases from epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma. Respir Investig, 2016; 54: 372-5. IF:2.400/CI:3 24. Ihara H, Tajima K, Yoshikawa H, Tajima M, Harada N, Takahashi F, Uekusa T, Nagaoka T, Takahashi K: Autofluorescence imaging bronchoscopy as a novel approach to the management of tracheobronchopathia osteochondroplastica: a case report. J Thorac Dis, 2016; 8: E1195-E1198. IF: 2.100/CI:4 25. Takagi H, Nagaoka T, Ando K, Tsutsumi T, Ichikawa M, Koyama R, Shimada N, Tobino K, Takahashi K: Efficacy of Antibiotics Prophylaxis after Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Preliminary Prospective Study. Journal of Pulmonary & Respiratory Medicine, 2017; 7: 416. IF:1.800/CI:0 26. Watanabe J, Togo S, Sumiyoshi I, Namba Y, Suina K, Mizuno T, Kadoya K, Motomura H, Iwai M, Nagaoka T, Sasaki S, Hayashi T, Uekusa T, Abe K, Urata Y, Sakurai F, Mizuguchi H, Kato S, Takahashi K: Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review. Oncotarget, 2018; 9: 24000-24013. IF: 5.168/CI:7 27. Kurokawa K, Asao T, Ko R, Nagaoka T, Suzuki K, Takahashi K: Severe mediastinitis over a month after endobronchial ultrasound-guided transbronchial needle aspiration. Respirol Case Rep, 2019; 7: e00426. IF:0.800/CI:4 28. Kuwasaki E, Nagaoka T, Ihara H, Tsutsumi T, Nakamura A, Yoshikawa H, Yoshida T, Watanabe J, Ichikawa M, Koyama R, Shimada N, Takahashi K: Age is an independent predictor in pathological diagnosis of sarcoidosis: a retrospective analysis of diagnosis by endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Dis, 2019; 11: 2175-2180. IF:2.100/CI: 1 29. Tsutsumi T, Nagaoka T, Yoshida T, Wang L, Kuriyama S, Suzuki Y, Nagata Y, Harada N, Kodama Y, Takahashi F, Morio Y, Takahashi K: Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation. PLoS One, 2019; 14: e0214697. IF:2.900/CI:30 30. Okamoto S, Suzuki K, Hayashi T, Muraki K, Nagaoka T, Nishino K, Sekimoto Y, Sasaki S, Takahashi K, Seyama K: Trans bronchial lung biopsy for the diagnosis of lymphangioleiomyomatosis: the severity of cystic lung destruction assessed by the modified Goddard scoring system as a predictor for establishing the diagnosis. Orphanet J Rare Dis, 2020; 15: 125. IF:3.400/CI:1 31. Nishioki T, Kato M, Kataoka S, Miura K, Nagaoka T, Takahashi K. Atezolizumab-induced fulminant type 1 diabetes mellitus occurring four months after treatment cessation. Respirol Case Rep, 2020; 8: e00685. IF:0.800/CI:4 32. Haraguchi M, Harada N, Watanabe J, Yoshikawa H, Shirai Y, Komura M, Koyama M, Ito J, Tsukune Y, Horimoto Y, Hayashi T, Nagaoka T, Uekusa T, Takahashi K. Disseminated nontuberculous mycobacteriosis and fungemia after second delivery in a patient with MonoMAC syndrome/GATA2 mutation: a case report. BMC Infect Dis. 2021; 21(1): 502-505. IF:3.400/CI:2 33. Sekimoto Y, Nagata Y, Kato M, Arai Y, Fujimoto Y, Takagi H, Shukuya T, Hayashi T, Nagaoka T, Yoshioka Y, Takahashi K. Idiopathic dendriform pulmonary ossification diagnosed by bronchoscopic lung cryobiopsy: A case report. Respirol Case Rep, 2021; 10(2): e0896. IF:0.800/CI:2 34. Yoshida T, Nagaoka T, Nagata Y, Suzuki Y, Tsutsumi T, Kuriyama S, Watanabe J, Togo S, Takahashi F, Matsushita M, Joki Y, Konishi H, Nunomura S, Izuhara K, Conway SJ, Takahashi K. Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signalling. Respirology, 2022; 27(7): 529-538. IF:6.600/CI:1 35. Ueda S, Ito J, Harada N, Harada S, Sasano H, Sandhu Y, Tanabe Y, Abe S, Shiota S, Kodama Y, Nagaoka T, Makino F, Chiba A, Akiba H, Atsuta R, Miyake　S, Takahashi K. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules, 2022; 12(4): 518. IF:4.800/CI:0 36. Iwamura C, Hirahara K, Kiuchi M, Ikehara S, Azuma K, Shimada T, Kuriyama S, Ohki S, Yamamoto E, Inaba Y, Shiko Y, Aoki A, Kokubo K, Hirasawa R, Hishiya T, Tsuji K, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Tsukamoto T, Nakamura S, Urushibara T, Kaneda S, Sakao S, Tobiume M, Suzuki Y, Tsujiwaki M, Kubo T, Hasegawa T, Nakase H, Nishida O, Takahashi K, Baba K, Iizumi Y, Okazaki T, Kimura MY, Yoshino I, Igari H, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Ikehara Y, Yokote K, Nakayama T. Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity. Proc Natl Acad Sci U S A, 2022; 119(33): e2203437119. IF: 9.400/CI:8 37. Heissig B, Salama Y, Iakoubov R, Vehreschild JJ, Rios R, Nogueira T, Vehreschild MJGT, Stecher M, Mori H, Lanznaster J, Adachi E, Jakob C, Tabe Y, Ruethrich M, Borgmann S, Naito T, Wille K, Valenti S, Hower M, Hattori N, Rieg S, Nagaoka T, Jensen BE, Yotsuyanagi H, Hertenstein B, Ogawa H, Wyen C, Kominami E, Roemmele C, Takahashi S, Rupp J, Takahashi K, Hanses F, Hattori K, On Behalf Of The Leoss Study Group. COVID-19 Severity and Thrombo-Inflammatory Response Linked to Ethnicity. Biomedicines, 2022; 10(10): 2549. IF: 3.900/CI:1 38. Sandhu Y, Harada N, Sasano H, Harada S, Ueda S, Takeshige T, Tanabe Y, Ishimori A, Matsuno K, Abe S, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K. Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma. Biomolecules, 2023; 13(3): 538. IF:4.800/CI:2 39. Sasano H, Harada N, Harada S, Takeshige T, Sandhu Y, Tanabe Y, Ishimori A, Matsuno K, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K.　Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int, 2024; 73(1): 94-106. IF:6.200/CI: 40. Suzuki Y, Nagaoka T, Terayama Y, Nagata Y, Yoshida T, Tsutsumi T, Kuriyama S, Matsushita M, Joki Y, Takasu K, Konishi H, Takahashi K. Prognostic analysis of pulmonary hypertension with lung parenchymal lesion: Comparison of mortality with and without connective tissue disease. Respir Investig, 2024; 62(1): 167-175. IF:2.400/CI: 41. Abe S, Yasuda M, Tobino K, Harada S, Sasano H, Tanabe Y, Sandhu Y, Takeshige T, Matsuno K, Asao T, Sueyasu T, Nishizawa S, Yoshimine K, Ko Y, Yoshimatsu Y, Tsuruno K, Ide H, Takagi H, Ito J, Nagaoka T, Harada N, Takahashi K.　Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma. J Asthma Allergy, 2024; 17: 325-337. IF:3.700/CI: 42. Aoki A, Iwamura C, Kiuchi M, Tsuji K, Sasaki A, Hishiya T, Hirasawa R, Kokubo K, Kuriyama S, Onodera A, Shimada T, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Nakamura S, Urushibara T, Kaneda S, Sakao S, Nishida O, Takahashi K, Kimura MY, Motohashi S, Igari H, Ikehara Y, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Kikuchi T, Nakayama T, Yokote K, Hirahara K. Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients. J Clin Immunol, 2024; 44(4): 104. IF:7.200/CI: 43. Tanabe N, Kumamaru H, Tamura Y, Kondoh Y, Nakayama K, Kinukawa N, Kimura T, Nishiyama O, Tsujino I, Shigeta A, Morio Y, Inoue Y, Kuraishi H, Hirata KI, Tanaka K, Kuwana M, Nagaoka T, Handa T, Sugimura K, Sakamaki F, Naito A, Taniguchi Y, Matsubara H, Hanaoka M, Inami T, Hayama N, Nishimura Y, Kimura H, Miyata H, Tatsumi K; JRPHS Group. Pulmonary Hypertension with Interstitial Pneumonia: Initial Treatment Effectiveness and Severity in a Japan Registry. JACC Asi, 2024; 4(5): 403-417. IF (-)/CI: 44. Nishioka Y, Murayama G, Kusaoi M, Takemasa D, Kaneda K, Kuga T, Hagiwara Y, Saito T, Yamaji Y, Suzuki Y, Nagaoka T, Yamaji K, Tamura N. Enhanced therapeutic efficacy of granulocyte/monocyte adsorption in rats with drug-induced colitis : Insights from a downsized bead column and newly formed B cells. Ther Apher Dial. 2024; Nov 20. IF:3.700/CI: 45. Goto A, Harada S, Sasano H, Sandhu Y, Tanabe Y, Abe S, Ueda S, Takeshige T, Matsuno K, Nagaoka T, Ito J, Atsuta R, Takahashi K, Harada N. Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period. J Asthma Allergy, 2024; 17:1173-1186. IF:1.500/CI: 46. Hirofumi Kamata, Kazufumi Takamatsu, Koichi Fukunaga, Shotaro Chubachi, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Katsushi Tanaka, Susumu Sato, Eri Hagiwara, Reoto Takei, Yasuhiro Kondoh, Takahiro Takazono, Midori Hashimoto, Sadatomo Tasaka, Takashi Ohrui, Yoshinori Tanino, Masamichi Mineshita, Yuko Komase, Kazuhito Miyazaki, Masanori Nishikawa, Akira Ando, Hideo Kita, Eiki Ichihara, Shinichiro Ohshimo, Yoriyuki Murata, Masayuki Ishida, Seiichi Kobayashi, Takahiro Uchida, Hiroki Tateno, Jun Ikari, Takeshi Terashima, Yutaka Kozu, Tomoya Tateishi, Masaharu Shinkai, Hironori Sagara, Yasuo To, Yoko Ito, Masaki Yamamoto, Yoshihiro Yamamoto, Toshiyuki Kita, Yutaka Ito, Keisuke Tomii, Yukio Fujita, Yoshihiro Funaki, Kazuhiro Yatera, Mari Yamasue, Kosaku Komiya, Satoko Kozawa, Hideaki Manabe, Hironao Hozumi, Tomoya Horiguchi, Takamasa Kitajima, Yasushi Nakano, Tetsutaro Nagaoka, Masayuki Hojo, Akinori Ebihara, Masayoshi Kobayashi, Koji Takayama, Torahiko Jinta, Toyomitsu Sawai, Yuichi Fukuda, Takeshi Kaneko, Kazuo Chin, Takashi Ogura, Hiroshi Mukae, Makoto Ishii, Akihito Yokoyama. Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020-2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society. Respir Investig, 2024; IF:2.400/CI: 47. Nishimaki T, Sasano H, Harada S, Takeshige T, Sandhu Y, Tanabe Y, Matsuno K, Nagaoka T, Ito J, Atsuta R, Ohuchi M, Yagishita S, Hamada A, Takahashi K, Harada N. Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment. J Allergy Clin Immunol Glob. 2025 Jan 16;4(2):100410. IF: /CI: . Journal of Allergy and Clinical Immunology: Global Volume 4, Issue 2, May 2025, 48. Nagata Y, Nagaoka T, Terayama Y, Suzuki Y, Yoshida T, Kuriyama S, Shiota S, Sato M, Takahashi K. The Potential of Pulmonary Vasodilators as a Bridging Therapy for Lung Transplantation: Two Cases of Interstitial Pneumonia With Pulmonary Hypertension During the Waiting Period for Lung Transplantation. Respirol Case Rep. 2025;13(3):e70136. IF:0.800/CI: 0. 49. Nagaoka T. Inhaled treprostinil for pulmonary hypertension due to interstitial lung disease. Respir Investig. 2025 Jul;63(4):608-609. F:2.0/CI: 0.

研究テーマ

肺循環障害、呼吸器内視鏡診断・治療

研究業績（論文）

1. Nagaoka T, Muramatsu M, Sato K, McMurtry I, Oka M, Fukuchi Y: Mild hypoxia causes severe pulmonary hypertension in fawn-hooded but not in Tester Moriyama rats. Respir Physiol, 2001; 127: 53-60. IF:1.900/CI:25
2. McMurtry IF, Bauer NR, Fagan KA, Nagaoka T, Gebb SA, Oka M: Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension. Adv Exp Med Biol, 2003; 543: 127-37. IF:3.650/CI:51
3. Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry I, Oka M: Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol, 2004; 287: L665-72. IF: 3.600/CI: 191
4. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, Oka M: Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med, 2005; 171: 494-9. IF:19.300/CI:201
5. Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M: Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn- hooded rat. J Appl Physiol, 2006; 100: 996-1002. IF:3.300/CI:78
6. Kaufman J, Sakao E, Oka M, Nagaoka T, Oliver-Picket CK, Jones PL, McMurtry IF, Gebb SA. Rho guanosine triphosphatases in lung development and pulmonary hypertension. Chest, 2005; 128: 610S. IF:9.500/CI:2
7. Oka M, Karoor V, Homma N, Nagaoka T, Sakao E, Golembeski SM, Limbird J, Imamura M, Gebb SA, Fagan KA, McMurtry IF: Dehydroepiandrosterone upregulates soluble guanylate cyclase and inhibits hypoxic pulmonary hypertension. Cardiovasc Res, 2007; 74: 377-87. IF:10.400/CI:69
8. Morio Y, Homma N, Takahashi H, Yamamoto A, Nagaoka T, Sato K, Muramatsu M, Fukuchi Y: Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs. J Vasc Res, 2007; 44: 325-35. IF:1.800/CI:12
9. Homma N, Nagaoka T, Morio Y, Ota H, Gebb SA, Karoor V, McMurtry IF, Oka M: Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol, 2007; 50: 697-702. IF:2.600/CI: 55
10. Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M: Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone. Am J Physiol Lung Cell Mol Physiol, 2008; 295: L71-8. IF: 3.600/CI: 66
11. Ochiai E, Kamei K, Watanabe A, Nagayoshi M, Tada Y, Nagaoka T, Sato K, Sato A, Shibuya K: Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. Int J Exp Pathol, 2008; 89: 201-8. IF:1.800/CI:15
12. Takahashi F, Tsuta K, Nagaoka T, Miyamoto H, Saito Y, Amano H, Uchida K, Morio Y, Shimizu K, Sasaki S, Tominaga S, Uekusa T, Izumi H, Anami Y, Matsuno Y, Takahashi K, Fukuchi Y: Successful resection of dermatomyositis associated with thymic carcinoma: report of a case. Surg Today, 2008; 38: 245-8. IF:1.700/CI:12
13. Takahashi F, Uchida K, Nagaoka T, Honma N, Cui R, Yoshioka M, Morio Y, Suzuki T, Tominaga S, Takahashi K, Fukuchi Y: Isolated congenital spleen agenesis: a rare cause of chronic thromboembolic pulmonary hypertension in an adult. Respirology, 2008; 13: 913-5. IF:6.600/CI:12
14. Sekiya M, Ishiwata T, Yoshimi K, Nagaoka T, Morio Y, Shiota S, Suzuki T, Seyama K, Takahashi K: Malignant pleurisy associated with primary lung cancer well controlled by pleurodesis using distilled water. Intern Med, 2009; 48: 1051-5. IF:1.000/CI:0
15. Takahashi F, Kumasaka T, Nagaoka T, Wakiya M, Fujii H, Shimizu K, Uchida K, Morio Y, Seyama K, Hino O, Takahashi K, Fukuchi Y: Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma. Pathol Int, 2009; 59: 752-6. IF:2.500/CI:38
16. Toba M, Nagaoka T, Morio Y, Sato K, Uchida K, Homma N, Takahashi K: Involvement of Rho kinase in the pathogenesis of acute pulmonary embolism- induced polystyrene microspheres in rats. Am J Physiol Lung Cell Mol Physiol, 2010; 298: L297-303. IF:3.600/CI:13
17. Nagahama K, Hayashi T, Nagaoka T, Kanemaru R, Togo S, Kumasaka T, Uekusa T, Seyama K, Takahashi K: Pulmonary Erdheim-Chester disease: A response to predonisolone. Respir Med CME, 2011; 4(2): 81-84. IF(-)/CI:-
18. Ohashi R, Kato M, Katsura Y, Takekawa H, Hoshika Y, Sugawara T, Yoshimi K, Togo S, Nagaoka T, Seyama K, Takahashi K, Tsuchiya K, Misawa S, Kikuchi K: Breakthrough lung Scedosporium prolificans infection with multiple cavity lesions in a patient receiving voriconazole for probable invasive aspergillosis associated with monoclonal gammopathy of undetermined significance (MGUS). Med Mycol J, 2011; 52: 33-8. IF:1.400/CI:10
19. Ando K, Motojima S, Doi T, Nagaoka T, Kaneko N, Aoshima M, Takahashi K: Effect of glucocorticoid monotherapy on pulmonary function and survival in Japanese patients with scleroderma-related interstitial lung disease. Respir Investig, 2013; 69-75. IF:2.400/CI: 24
20. Kuriyama S, Morio Y, Toba M, Nagaoka T, Takahashi F, Iwakami S, Seyama K, Takahashi K: Genistein attenuates hypoxic pulmonary hypertension via enhanced nitric oxide signaling and the erythropoietin system. Am J Physiol Lung Cell Mol Physiol, 2014; 306: L996-L1005. IF: 3.600/CI:29
21. Ando K, Kuraishi H, Nagaoka T, Tsutsumi T, Hoshika Y, Kimura T, Ienaga H, Morio Y, Takahashi K: Potential Role of CT Metrics in Chronic Obstructive Pulmonary Disease with Pulmonary Hypertension. Lung, 2015; 193: 911-8. IF:4.600/CI: 10
22. Sekimoto Y, Kato M, Shukuya T, Koyama R, Nagaoka T, Takahashi K: Bevacizumab- induced chronic interstitial pneumonia during maintenance therapy in non-small cell lung cancer. Respirol Case Rep, 2016; 4(2): e00151. IF:0.800/CI:5
23. Kanemaru R, Morio Y, Takekawa H, Jo H, Kasuga F, Koyama R, Shiota S, Nagaoka T, Takahashi K: Successful treatment with weekly high-dose erlotinib against meningeal metastases from epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma. Respir Investig, 2016; 54: 372-5. IF:2.400/CI:3
24. Ihara H, Tajima K, Yoshikawa H, Tajima M, Harada N, Takahashi F, Uekusa T, Nagaoka T, Takahashi K: Autofluorescence imaging bronchoscopy as a novel approach to the management of tracheobronchopathia osteochondroplastica: a case report. J Thorac Dis, 2016; 8: E1195-E1198. IF: 2.100/CI:4
25. Takagi H, Nagaoka T, Ando K, Tsutsumi T, Ichikawa M, Koyama R, Shimada N, Tobino K, Takahashi K: Efficacy of Antibiotics Prophylaxis after Endobronchial Ultrasound-guided Transbronchial Needle Aspiration: A Preliminary Prospective Study. Journal of Pulmonary & Respiratory Medicine, 2017; 7: 416. IF:1.800/CI:0
26. Watanabe J, Togo S, Sumiyoshi I, Namba Y, Suina K, Mizuno T, Kadoya K, Motomura H, Iwai M, Nagaoka T, Sasaki S, Hayashi T, Uekusa T, Abe K, Urata Y, Sakurai F, Mizuguchi H, Kato S, Takahashi K: Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review. Oncotarget, 2018; 9: 24000-24013. IF: 5.168/CI:7
27. Kurokawa K, Asao T, Ko R, Nagaoka T, Suzuki K, Takahashi K: Severe mediastinitis over a month after endobronchial ultrasound-guided transbronchial needle aspiration. Respirol Case Rep, 2019; 7: e00426. IF:0.800/CI:4
28. Kuwasaki E, Nagaoka T, Ihara H, Tsutsumi T, Nakamura A, Yoshikawa H, Yoshida T, Watanabe J, Ichikawa M, Koyama R, Shimada N, Takahashi K: Age is an independent predictor in pathological diagnosis of sarcoidosis: a retrospective analysis of diagnosis by endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Dis, 2019; 11: 2175-2180. IF:2.100/CI: 1
29. Tsutsumi T, Nagaoka T, Yoshida T, Wang L, Kuriyama S, Suzuki Y, Nagata Y, Harada N, Kodama Y, Takahashi F, Morio Y, Takahashi K: Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation. PLoS One, 2019; 14: e0214697. IF:2.900/CI:30
30. Okamoto S, Suzuki K, Hayashi T, Muraki K, Nagaoka T, Nishino K, Sekimoto Y, Sasaki S, Takahashi K, Seyama K: Trans bronchial lung biopsy for the diagnosis of lymphangioleiomyomatosis: the severity of cystic lung destruction assessed by the modified Goddard scoring system as a predictor for establishing the diagnosis. Orphanet J Rare Dis, 2020; 15: 125. IF:3.400/CI:1
31. Nishioki T, Kato M, Kataoka S, Miura K, Nagaoka T, Takahashi K. Atezolizumab-induced fulminant type 1 diabetes mellitus occurring four months after treatment cessation. Respirol Case Rep, 2020; 8: e00685. IF:0.800/CI:4
32. Haraguchi M, Harada N, Watanabe J, Yoshikawa H, Shirai Y, Komura M, Koyama M, Ito J, Tsukune Y, Horimoto Y, Hayashi T, Nagaoka T, Uekusa T, Takahashi K. Disseminated nontuberculous mycobacteriosis and fungemia after second delivery in a patient with MonoMAC syndrome/GATA2 mutation: a case report. BMC Infect Dis. 2021; 21(1): 502-505. IF:3.400/CI:2
33. Sekimoto Y, Nagata Y, Kato M, Arai Y, Fujimoto Y, Takagi H, Shukuya T, Hayashi T, Nagaoka T, Yoshioka Y, Takahashi K. Idiopathic dendriform pulmonary ossification diagnosed by bronchoscopic lung cryobiopsy: A case report. Respirol Case Rep, 2021; 10(2): e0896. IF:0.800/CI:2
34. Yoshida T, Nagaoka T, Nagata Y, Suzuki Y, Tsutsumi T, Kuriyama S, Watanabe J, Togo S, Takahashi F, Matsushita M, Joki Y, Konishi H, Nunomura S, Izuhara K, Conway SJ, Takahashi K. Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signalling. Respirology, 2022; 27(7): 529-538. IF:6.600/CI:1
35. Ueda S, Ito J, Harada N, Harada S, Sasano H, Sandhu Y, Tanabe Y, Abe S, Shiota S, Kodama Y, Nagaoka T, Makino F, Chiba A, Akiba H, Atsuta R, Miyake　S, Takahashi K. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules, 2022; 12(4): 518. IF:4.800/CI:0
36. Iwamura C, Hirahara K, Kiuchi M, Ikehara S, Azuma K, Shimada T, Kuriyama S, Ohki S, Yamamoto E, Inaba Y, Shiko Y, Aoki A, Kokubo K, Hirasawa R, Hishiya T, Tsuji K, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Tsukamoto T, Nakamura S, Urushibara T, Kaneda S, Sakao S, Tobiume M, Suzuki Y, Tsujiwaki M, Kubo T, Hasegawa T, Nakase H, Nishida O, Takahashi K, Baba K, Iizumi Y, Okazaki T, Kimura MY, Yoshino I, Igari H, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Ikehara Y, Yokote K, Nakayama T. Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity. Proc Natl Acad Sci U S A, 2022; 119(33): e2203437119. IF: 9.400/CI:8
37. Heissig B, Salama Y, Iakoubov R, Vehreschild JJ, Rios R, Nogueira T, Vehreschild MJGT, Stecher M, Mori H, Lanznaster J, Adachi E, Jakob C, Tabe Y, Ruethrich M, Borgmann S, Naito T, Wille K, Valenti S, Hower M, Hattori N, Rieg S, Nagaoka T, Jensen BE, Yotsuyanagi H, Hertenstein B, Ogawa H, Wyen C, Kominami E, Roemmele C, Takahashi S, Rupp J, Takahashi K, Hanses F, Hattori K, On Behalf Of The Leoss Study Group. COVID-19 Severity and Thrombo-Inflammatory Response Linked to Ethnicity. Biomedicines, 2022; 10(10): 2549. IF: 3.900/CI:1
38. Sandhu Y, Harada N, Sasano H, Harada S, Ueda S, Takeshige T, Tanabe Y, Ishimori A, Matsuno K, Abe S, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K. Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma. Biomolecules, 2023; 13(3): 538. IF:4.800/CI:2
39. Sasano H, Harada N, Harada S, Takeshige T, Sandhu Y, Tanabe Y, Ishimori A, Matsuno K, Nagaoka T, Ito J, Chiba A, Akiba H, Atsuta R, Izuhara K, Miyake S, Takahashi K.　Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int, 2024; 73(1): 94-106. IF:6.200/CI:
40. Suzuki Y, Nagaoka T, Terayama Y, Nagata Y, Yoshida T, Tsutsumi T, Kuriyama S, Matsushita M, Joki Y, Takasu K, Konishi H, Takahashi K. Prognostic analysis of pulmonary hypertension with lung parenchymal lesion: Comparison of mortality with and without connective tissue disease. Respir Investig, 2024; 62(1): 167-175. IF:2.400/CI:
41. Abe S, Yasuda M, Tobino K, Harada S, Sasano H, Tanabe Y, Sandhu Y, Takeshige T, Matsuno K, Asao T, Sueyasu T, Nishizawa S, Yoshimine K, Ko Y, Yoshimatsu Y, Tsuruno K, Ide H, Takagi H, Ito J, Nagaoka T, Harada N, Takahashi K.　Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma. J Asthma Allergy, 2024; 17: 325-337. IF:3.700/CI:
42. Aoki A, Iwamura C, Kiuchi M, Tsuji K, Sasaki A, Hishiya T, Hirasawa R, Kokubo K, Kuriyama S, Onodera A, Shimada T, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Nakamura S, Urushibara T, Kaneda S, Sakao S, Nishida O, Takahashi K, Kimura MY, Motohashi S, Igari H, Ikehara Y, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Kikuchi T, Nakayama T, Yokote K, Hirahara K. Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients. J Clin Immunol, 2024; 44(4): 104. IF:7.200/CI:
43. Tanabe N, Kumamaru H, Tamura Y, Kondoh Y, Nakayama K, Kinukawa N, Kimura T, Nishiyama O, Tsujino I, Shigeta A, Morio Y, Inoue Y, Kuraishi H, Hirata KI, Tanaka K, Kuwana M, Nagaoka T, Handa T, Sugimura K, Sakamaki F, Naito A, Taniguchi Y, Matsubara H, Hanaoka M, Inami T, Hayama N, Nishimura Y, Kimura H, Miyata H, Tatsumi K; JRPHS Group. Pulmonary Hypertension with Interstitial Pneumonia: Initial Treatment Effectiveness and Severity in a Japan Registry. JACC Asi, 2024; 4(5): 403-417. IF (-)/CI:
44. Nishioka Y, Murayama G, Kusaoi M, Takemasa D, Kaneda K, Kuga T, Hagiwara Y, Saito T, Yamaji Y, Suzuki Y, Nagaoka T, Yamaji K, Tamura N. Enhanced therapeutic efficacy of granulocyte/monocyte adsorption in rats with drug-induced colitis : Insights from a downsized bead column and newly formed B cells. Ther Apher Dial. 2024; Nov 20. IF:3.700/CI:
45. Goto A, Harada S, Sasano H, Sandhu Y, Tanabe Y, Abe S, Ueda S, Takeshige T, Matsuno K, Nagaoka T, Ito J, Atsuta R, Takahashi K, Harada N. Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period. J Asthma Allergy, 2024; 17:1173-1186. IF:1.500/CI:
46. Hirofumi Kamata, Kazufumi Takamatsu, Koichi Fukunaga, Shotaro Chubachi, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Katsushi Tanaka, Susumu Sato, Eri Hagiwara, Reoto Takei, Yasuhiro Kondoh, Takahiro Takazono, Midori Hashimoto, Sadatomo Tasaka, Takashi Ohrui, Yoshinori Tanino, Masamichi Mineshita, Yuko Komase, Kazuhito Miyazaki, Masanori Nishikawa, Akira Ando, Hideo Kita, Eiki Ichihara, Shinichiro Ohshimo, Yoriyuki Murata, Masayuki Ishida, Seiichi Kobayashi, Takahiro Uchida, Hiroki Tateno, Jun Ikari, Takeshi Terashima, Yutaka Kozu, Tomoya Tateishi, Masaharu Shinkai, Hironori Sagara, Yasuo To, Yoko Ito, Masaki Yamamoto, Yoshihiro Yamamoto, Toshiyuki Kita, Yutaka Ito, Keisuke Tomii, Yukio Fujita, Yoshihiro Funaki, Kazuhiro Yatera, Mari Yamasue, Kosaku Komiya, Satoko Kozawa, Hideaki Manabe, Hironao Hozumi, Tomoya Horiguchi, Takamasa Kitajima, Yasushi Nakano, Tetsutaro Nagaoka, Masayuki Hojo, Akinori Ebihara, Masayoshi Kobayashi, Koji Takayama, Torahiko Jinta, Toyomitsu Sawai, Yuichi Fukuda, Takeshi Kaneko, Kazuo Chin, Takashi Ogura, Hiroshi Mukae, Makoto Ishii, Akihito Yokoyama. Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020-2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society. Respir Investig, 2024; IF:2.400/CI:
47. Nishimaki T, Sasano H, Harada S, Takeshige T, Sandhu Y, Tanabe Y, Matsuno K, Nagaoka T, Ito J, Atsuta R, Ohuchi M, Yagishita S, Hamada A, Takahashi K, Harada N. Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment. J Allergy Clin Immunol Glob. 2025 Jan 16;4(2):100410. IF: /CI: .
Journal of Allergy and Clinical Immunology: Global Volume 4, Issue 2, May 2025,
48. Nagata Y, Nagaoka T, Terayama Y, Suzuki Y, Yoshida T, Kuriyama S, Shiota S, Sato M, Takahashi K. The Potential of Pulmonary Vasodilators as a Bridging Therapy for Lung Transplantation: Two Cases of Interstitial Pneumonia With Pulmonary Hypertension During the Waiting Period for Lung Transplantation. Respirol Case Rep. 2025;13(3):e70136. IF:0.800/CI: 0.
49. Nagaoka T. Inhaled treprostinil for pulmonary hypertension due to interstitial lung disease. Respir Investig. 2025 Jul;63(4):608-609. F:2.0/CI: 0.

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長岡 鉄太郎（ナガオカ テツタロウ）

長岡鉄太郎（ナガオカテツタロウ）