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奥村康（オクムラコウ）

研究テーマ	免疫学（リンパ球機能分子の研究、細胞傷害機序の解明、免疫寛容の研究）
研究業績（論文）	1)Development and characterization of cDNA resources for the common marmoset: one of the experimental primate models.Tatsumoto S, Adati N, Tohtoki Y, Sakaki Y, Boroviak T, Habu S, Okano H, Suemizu H, Sasaki E, Satake M. DNA Research 2013 20:255-262. 2)Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged-1. Negishi N, Ito R, Matsuo K, Yahata T, Aoki K, Ohya K, Hozumi K, Ando K, Tamaoki N, Ito M. and Habu S.　Exp Hematol. 2014 Feb 13. pii: S0301-472X(14)00061-7. doi: 1 3)Commensal bacteria regulate thymic Aire expression. Nakajima A, Negishi N, Tsurui H, Kadowaki-Ohtsuji N, Maeda K, Nannmo M, Yamaguchi Y, simizu N, Yagita H, Okumura K .and Habu S. PLOS ONE 2014 (Aug.26) 9(8): 1-7, 4)Role of Notch signaling in the construction of pancreatic acinar structure. Nakano Y,1,5, Negishi N1,4, Gocho S, Mine T2, Sakurai Y1, Abe K3, Yagita H4, Habu S4, Kageyam R6, Kawaguch Y5,and Hozumi K. Gene to Cells On line open 2015 5)Delta-like 4-mediated Notch signaling is required for early T cell development in a three-dimensional thymic structure. Ken-ichi Hirano, Naoko Negishi, Masaki Yazawa, Hideo Yagita, Sonoko Habu and Katsuto Hozumi, EJI 2015 6)Common marmoset CD117-positive hematopoietic cells possess multipotency. Shimada S, Numorura S, Mori S, Suemizu H, Itoh T, Takabayashi S, Okada Y, Yahata T, Shiina T, Katoh H, Suzuki R, Tani K, Ando K, Yagita H, Habu S, Sasaki E and Kametani Y.　Int. Immunol 2015 7)Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H. Stem Cells Transl Med. 4(7):708-19. 2015 8)Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. Junko Nishio1,2, Minato Baba1,2, Koji Atarashi2, Takeshi Tanoue2, Hideo Negishi1,2, Hideyuki Yanai 1,2,3, Sonoko Habu4, Shohei Hori5, Kenya Honda2,* and Tadatsugu Taniguchi1,2 Proc Natl Acad Sci U S A. 13;112(41):12770-5. 2015 Oct 9)Treatment with Anti-FcεRIα (MAR-1) Antibody Prevents Acute Islet Allograft Rejection in a Murine Model. Yazawa N, Imaizumi T, Makuuchi H, Tsuchiya I, Tanaka M, Inokuchi S, Habu S, Nakagohri T. Tokai J Exp Clin Med. 2015 Dec 20;40(4):141-8. 10)Inhibitory function of NKT cells during early induction phase of nickel allergy.Okuno H1, Satoh M1, Takeuchi E1, Eshima K1, Terashima M2, Komotori J3, Habu S4, Tamauchi H5, Iwabuchi K1. Immunobiol. 221:833-838 2016 11)5. Generation of a nonhuman primate model of severe combined immunodeficiency using highly efficient genome editing. Sato R., Kumita W, Henry R, Sakura T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Haka J, and Sasaki E. Cell Stem Cell 19, 127-138, 2016 12)4. A Pilot study of operational tolerance with a regulatory T-cell based cell therapy in living donor liver transplantation. Todo S, Yamashita K, Goto R, Zaitsu T, Shimamura T, Kamiyama T, Sato N, sugita J, Hatanaka K, Bashuda H, Habu S and Okumura K. Hepatology 64 632-643, 2016 13)Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A. Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response.　Allergol Int. 2017;66:472-478. 14)Yao T, Fujimura T, Murayama K, Okumura K, Seko Y. Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells. Cells. 2017;6 15)Yanashima K, Chieosilapatham P, Yoshimoto E, Okumura K, Ogawa H, Niyonsaba F. Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-ĸB-sensitive pathways. Immunol Res. 2017;65:920-931. 16)Yashiro T, Kasakura K, Oda Y, Kitamura N, Inoue A, Nakamura S, Yokoyama H, Fukuyama K, Hara M, Ogawa H, Okumura K, Nishiyama M, Nishiyama C. The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c. Int Immunol. 2017;29:87-94. 17)Honjo, A., Nakano, N.*, Yamazaki, S., Hara, M., Uchida, K., Kitaura, J., Nishiyama, C., Yagita, H., Ohtsuka, Y., Ogawa, H., Okumura, K., and Shimizu, T. Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia. J Allergy Clin Immunol. 2017;139:987-996.e10. 18)Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H. Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production. J Biol Chem. 2017;292:205-216. 19)Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J. Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 2017;292: 2924-2932. 20)Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H. The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci. 2017;88:117-125. 21)Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S. Cutting Edge: Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice. J Immunol. 2017;199:3733-3737. 22)Nagaoka M, Yashiro T, Uchida Y, Ando T, Hara M, Arai H, Ogawa H, Okumura K, Kasakura K, Nishiyama C. The orphan nuclear receptor NR4A3 is involved in the function of dendritic cells. J Immunol. 2017;199:2958-2967. 23)Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice. J Immunol. 2017;199:3516-3524. 24)Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S. Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice. J Invest Dermatol. 2017;137:1578-1582. 25)Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, Smyth MJ. IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting. Nat Commun. 2017;8:14607.

研究テーマ

免疫学（リンパ球機能分子の研究、細胞傷害機序の解明、免疫寛容の研究）

研究業績（論文）

1)Development and characterization of cDNA resources for the common marmoset: one of the experimental primate models.Tatsumoto S, Adati N, Tohtoki Y, Sakaki Y, Boroviak T, Habu S, Okano H, Suemizu H, Sasaki E, Satake M. DNA Research 2013 20:255-262.

2)Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged-1. Negishi N, Ito R, Matsuo K, Yahata T, Aoki K, Ohya K, Hozumi K, Ando K, Tamaoki N, Ito M. and Habu S.　Exp Hematol. 2014 Feb 13. pii: S0301-472X(14)00061-7. doi: 1

3)Commensal bacteria regulate thymic Aire expression. Nakajima A, Negishi N, Tsurui H, Kadowaki-Ohtsuji N, Maeda K, Nannmo M, Yamaguchi Y, simizu N, Yagita H, Okumura K .and Habu S. PLOS ONE
2014 (Aug.26) 9(8): 1-7,

4)Role of Notch signaling in the construction of pancreatic acinar structure. Nakano Y,1,5, Negishi N1,4, Gocho S, Mine T2, Sakurai Y1, Abe K3, Yagita H4, Habu S4, Kageyam R6, Kawaguch Y5,*and Hozumi K. Gene to Cells On line open 2015

5)Delta-like 4-mediated Notch signaling is required for early T cell development in a three-dimensional thymic structure. Ken-ichi Hirano, Naoko Negishi, Masaki Yazawa, Hideo Yagita, Sonoko Habu and Katsuto Hozumi, EJI 2015

6)Common marmoset CD117-positive hematopoietic cells possess multipotency. Shimada S, Numorura S, Mori S, Suemizu H, Itoh T, Takabayashi S, Okada Y, Yahata T, Shiina T, Katoh H, Suzuki R, Tani K, Ando K, Yagita H, Habu S, Sasaki E and Kametani Y.　Int. Immunol 2015

7)Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H. Stem Cells Transl Med. 4(7):708-19. 2015

8)Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis. Junko Nishio1,2, Minato Baba1,2, Koji Atarashi2*, Takeshi Tanoue2, Hideo Negishi1,2, Hideyuki Yanai 1,2,3, Sonoko Habu4, Shohei Hori5, Kenya Honda2,* and Tadatsugu Taniguchi1,2 Proc Natl Acad Sci U S A. 13;112(41):12770-5. 2015 Oct

9)Treatment with Anti-FcεRIα (MAR-1) Antibody Prevents Acute Islet Allograft Rejection in a Murine Model. Yazawa N, Imaizumi T, Makuuchi H, Tsuchiya I, Tanaka M, Inokuchi S, Habu S, Nakagohri T. Tokai J Exp Clin Med. 2015 Dec 20;40(4):141-8.

10)Inhibitory function of NKT cells during early induction phase of nickel allergy.Okuno H1, Satoh M1, Takeuchi E1, Eshima K1, Terashima M2, Komotori J3, Habu S4, Tamauchi H5, Iwabuchi K1. Immunobiol. 221:833-838 2016

11)5. Generation of a nonhuman primate model of severe combined immunodeficiency using highly efficient genome editing. Sato R., Kumita W, Henry R, Sakura T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Haka J, and Sasaki E. Cell Stem Cell 19, 127-138, 2016

12)4. A Pilot study of operational tolerance with a regulatory T-cell based cell therapy in living donor liver transplantation. Todo S, Yamashita K, Goto R, Zaitsu T, Shimamura T, Kamiyama T, Sato N, sugita J, Hatanaka K, Bashuda H, Habu S and Okumura K. Hepatology 64 632-643, 2016

13)Kawauchi T, Ishimaru K, Nakamura Y, Nakano N, Hara M, Ogawa H, Okumura K, Shibata S, Nakao A. Clock-dependent temporal regulation of IL-33/ST2-mediated mast cell response.　Allergol Int. 2017;66:472-478.

14)Yao T, Fujimura T, Murayama K, Okumura K, Seko Y. Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) Plays a Critical Role in High Glucose-Induced Apoptosis in Rat Cardiac Myocytes and Murine Pancreatic β-Cells. Cells. 2017;6

15)Yanashima K, Chieosilapatham P, Yoshimoto E, Okumura K, Ogawa H, Niyonsaba F. Innate defense regulator IDR-1018 activates human mast cells through G protein-, phospholipase C-, MAPK- and NF-ĸB-sensitive pathways. Immunol Res. 2017;65:920-931.

16)Yashiro T, Kasakura K, Oda Y, Kitamura N, Inoue A, Nakamura S, Yokoyama H, Fukuyama K, Hara M, Ogawa H, Okumura K, Nishiyama M, Nishiyama C. The hematopoietic cell-specific transcription factor PU.1 is critical for expression of CD11c. Int Immunol. 2017;29:87-94.

17)Honjo, A., Nakano, N.*, Yamazaki, S., Hara, M., Uchida, K., Kitaura, J., Nishiyama, C., Yagita, H., Ohtsuka, Y., Ogawa, H., Okumura, K., and Shimizu, T. Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia. J Allergy Clin Immunol. 2017;139:987-996.e10.

18)Nishina T, Deguchi Y, Miura R, Yamazaki S, Shinkai Y, Kojima Y, Okumura K, Kumagai Y, Nakano H. Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production. J Biol Chem. 2017;292:205-216.

19)Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J. Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 2017;292: 2924-2932.

20)Chieosilapatham P, Niyonsaba F, Kiatsurayanon C, Okumura K, Ikeda S, Ogawa H. The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors. J Dermatol Sci. 2017;88:117-125.

21)Isshiki T, Akiba H, Nakayama M, Harada N, Okumura K, Homma S, Miyake S. Cutting Edge: Anti-TIM-3 Treatment Exacerbates Pulmonary Inflammation and Fibrosis in Mice. J Immunol. 2017;199:3733-3737.

22)Nagaoka M, Yashiro T, Uchida Y, Ando T, Hara M, Arai H, Ogawa H, Okumura K, Kasakura K, Nishiyama C. The orphan nuclear receptor NR4A3 is involved in the function of dendritic cells. J Immunol. 2017;199:2958-2967.

23)Nakajima A, Kaga N, Nakanishi Y, Ohno H, Miyamoto J, Kimura I, Hori S, Sasaki T, Hiramatsu K, Okumura K, Miyake S, Habu S, Watanabe S. Maternal High Fiber Diet during Pregnancy and Lactation Influences Regulatory T Cell Differentiation in Offspring in Mice. J Immunol. 2017;199:3516-3524.

24)Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S. Skin Treatment with Detergent Promotes Protease Allergen-Dependent Epicutaneous Sensitization in a Manner Different from Tape Stripping in Mice. J Invest Dermatol. 2017;137:1578-1582.

25)Takeda K, Nakayama M, Hayakawa Y, Kojima Y, Ikeda H, Imai N, Ogasawara K, Okumura K, Thomas DM, Smyth MJ. IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting. Nat Commun. 2017;8:14607.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

奥村 康（オクムラ コウ）

奥村康（オクムラコウ）