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樫山拓（カシヤマタク）

研究テーマ	APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明
研究業績（論文）	1. Nakanishi Y, Matsuda N, Aizawa K, Kashiyama T, Yamamoto K, Mimura T, Ikeda M, Maeshima M: Molecular cloning and sequencing of the cDNA for vacuolar H+-pyrophosphatase from Chara corallina. Biochimica Et Biophysica Acta-Biomembranes 1418:245-250, 1999, IF:3.438/CI:17 2. Yamamoto K, Hamada S, Kashiyama T: Myosins from plants. Cellular and molecular life sciences : CMLS 56:227-232, 1999, IF:6.721/CI:21 3. Kashiyama T, Kimura N, Mimura T, Yamamoto K: Cloning and characterization of a myosin from characean alga, the fastest motor protein in the world. Journal of Biochemistry 127:1065-1070, 2000, IF:2.116/CI:45 4. Awata J, Saitoh K, Shimada K, Kashiyama T, Yamamoto K: Effects of Ca2+ and calmodulin on the motile activity of characean myosin in vitro. Plant and Cell Physiology 42:828-834, 2001, IF:4.059/CI:20 5. Kashiyama T, Ito K, Yamamoto K: Functional expression of a chimeric myosin-containing motor domain of Chara myosin and neck and tail domains of Dictyostelium myosin II. Journal of Molecular Biology 311:461-466, 2001, IF:4.894/CI:10 6. Awata J, Kashiyama T, Ito K, Yamamoto K: Some motile properties of fast characean myosin. Journal of Molecular Biology 326:659-663, 2003, IF:4.894/CI:12 7. Ito K, Kashiyama T, Shimada K, Yamaguchi A, Awata J, Hachikubo Y, Manstein DJ, Yamamoto K: Recombinant motor domain constructs of Chara corallina myosin display fast motility and high ATPase activity. Biochemical and Biophysical Research Communications 312:958-964, 2003, IF:2.559/CI:35 8. Seki M, Awata J, Shimada K, Kashiyama T, Ito K, Yamamoto K: Susceptibility of Chara myosin to SH reagents. Plant and Cell Physiology 44:201-205, 2003, IF:4.059/CI:5 9. Seki M, Kashiyama T, Hachikubo Y, Ito K, Yamamoto K: Importance of the converter region for the motility of myosin as revealed by the studies on chimeric Chara myosins. Journal of Molecular Biology 344:311-315, 2004, IF:4.894/CI:3 10. Ito K, Ikebe M, Kashiyama T, Mogami T, Kon T, Yamamoto K: Kinetic mechanism of the fastest motor protein, Chara myosin. Journal of Biological Chemistry 282:19534-19545, 2007, IF:4.01/CI:43 11. Nunokawa S-y, Anan H, Shimada K, Hachikubo Y, Kashiyama T, Ito K, Yamamoto K: Binding of Chara myosin globular tail domain to phospholipid vesicles. Plant and Cell Physiology 48:1558-1566, 2007, IF:4.059/CI:5 12. Kobayashi T, Morone N, Kashiyama T, Oyamada H, Kurebayashi N, Murayama T: Engineering a Novel Multifunctional Green Fluorescent Protein Tag for a Wide Variety of Protein Research. Plos One 3, 2008, IF:2.766/CI:26 13. Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Akagi T, Hashikawa T, Nukina N: Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. Journal of Cell Biology 183:339-352, 2008, IF:8.784/CI:40 14. Kashiyama T, Murayama T, Suzuki E, Allen PD, Ogawa Y: Frog alpha- and beta-Ryanodine Receptors Provide Distinct Intracellular Ca2+ Signals in a Myogenic Cell Line. Plos One 5, 2010, IF:2.766/CI:5 15. Kamikubo Y, Shimomura T, Fujita Y, Tabata T, Kashiyama T, Sakurai T, Fukurotani K, Kano M: Functional Cooperation of Metabotropic Adenosine and Glutamate Receptors Regulates Postsynaptic Plasticity in the Cerebellum. Journal of Neuroscience 33:18661-18671, 2013, IF:5.97/CI:10 16. Kaneshiro N, Imaoka R, Komai M, Kashiyama T, Sakurai T, Uehara T, Takasugi N: Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells. Biochemical and Biophysical Research Communications 501:1023-1028, 2018, IF:2.559/CI:0 17. Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T: TMEM30A is a candidate interacting partner for the beta-carboxyl-terminal fragment of amyloid-beta precursor protein in endosomes. PloS one 13:e0200988-e0200988, 2018, IF:2.766/CI:0 18. Sasaki R, Kurebayashi N, Eguchi H, Horimoto Y, Shiga T, Miyazaki S, Kashiyama T, Akamatsu W, Saito M. Involvement of kallikrein-PAR2-proinflammatory pathway in severe trastuzumab-induced cardiotoxicity. Cancer Sci. 2022

研究テーマ

APP-BACE1結合仲介分子によるアミロイドβ産生制御機構の解明

研究業績（論文）

1. Nakanishi Y, Matsuda N, Aizawa K, Kashiyama T, Yamamoto K, Mimura T, Ikeda M, Maeshima M: Molecular cloning and sequencing of the cDNA for vacuolar H+-pyrophosphatase from Chara corallina. Biochimica Et Biophysica Acta-Biomembranes 1418:245-250, 1999, IF:3.438/CI:17
2. Yamamoto K, Hamada S, Kashiyama T: Myosins from plants. Cellular and molecular life sciences : CMLS 56:227-232, 1999, IF:6.721/CI:21
3. Kashiyama T, Kimura N, Mimura T, Yamamoto K: Cloning and characterization of a myosin from characean alga, the fastest motor protein in the world. Journal of Biochemistry 127:1065-1070, 2000, IF:2.116/CI:45
4. Awata J, Saitoh K, Shimada K, Kashiyama T, Yamamoto K: Effects of Ca2+ and calmodulin on the motile activity of characean myosin in vitro. Plant and Cell Physiology 42:828-834, 2001, IF:4.059/CI:20
5. Kashiyama T, Ito K, Yamamoto K: Functional expression of a chimeric myosin-containing motor domain of Chara myosin and neck and tail domains of Dictyostelium myosin II. Journal of Molecular Biology 311:461-466, 2001, IF:4.894/CI:10
6. Awata J, Kashiyama T, Ito K, Yamamoto K: Some motile properties of fast characean myosin. Journal of Molecular Biology 326:659-663, 2003, IF:4.894/CI:12
7. Ito K, Kashiyama T, Shimada K, Yamaguchi A, Awata J, Hachikubo Y, Manstein DJ, Yamamoto K: Recombinant motor domain constructs of Chara corallina myosin display fast motility and high ATPase activity. Biochemical and Biophysical Research Communications 312:958-964, 2003, IF:2.559/CI:35
8. Seki M, Awata J, Shimada K, Kashiyama T, Ito K, Yamamoto K: Susceptibility of Chara myosin to SH reagents. Plant and Cell Physiology 44:201-205, 2003, IF:4.059/CI:5
9. Seki M, Kashiyama T, Hachikubo Y, Ito K, Yamamoto K: Importance of the converter region for the motility of myosin as revealed by the studies on chimeric Chara myosins. Journal of Molecular Biology 344:311-315, 2004, IF:4.894/CI:3
10. Ito K, Ikebe M, Kashiyama T, Mogami T, Kon T, Yamamoto K: Kinetic mechanism of the fastest motor protein, Chara myosin. Journal of Biological Chemistry 282:19534-19545, 2007, IF:4.01/CI:43
11. Nunokawa S-y, Anan H, Shimada K, Hachikubo Y, Kashiyama T, Ito K, Yamamoto K: Binding of Chara myosin globular tail domain to phospholipid vesicles. Plant and Cell Physiology 48:1558-1566, 2007, IF:4.059/CI:5
12. Kobayashi T, Morone N, Kashiyama T, Oyamada H, Kurebayashi N, Murayama T: Engineering a Novel Multifunctional Green Fluorescent Protein Tag for a Wide Variety of Protein Research. Plos One 3, 2008, IF:2.766/CI:26
13. Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Akagi T, Hashikawa T, Nukina N: Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing. Journal of Cell Biology 183:339-352, 2008, IF:8.784/CI:40
14. Kashiyama T, Murayama T, Suzuki E, Allen PD, Ogawa Y: Frog alpha- and beta-Ryanodine Receptors Provide Distinct Intracellular Ca2+ Signals in a Myogenic Cell Line. Plos One 5, 2010, IF:2.766/CI:5
15. Kamikubo Y, Shimomura T, Fujita Y, Tabata T, Kashiyama T, Sakurai T, Fukurotani K, Kano M: Functional Cooperation of Metabotropic Adenosine and Glutamate Receptors Regulates Postsynaptic Plasticity in the Cerebellum. Journal of Neuroscience 33:18661-18671, 2013, IF:5.97/CI:10
16. Kaneshiro N, Imaoka R, Komai M, Kashiyama T, Sakurai T, Uehara T, Takasugi N: Functional analysis of juxta- and intra-membrane domains of murine APP by genome editing in Neuro2a cells. Biochemical and Biophysical Research Communications 501:1023-1028, 2018, IF:2.559/CI:0
17. Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T: TMEM30A is a candidate interacting partner for the beta-carboxyl-terminal fragment of amyloid-beta precursor protein in endosomes. PloS one 13:e0200988-e0200988, 2018, IF:2.766/CI:0
18. Sasaki R, Kurebayashi N, Eguchi H, Horimoto Y, Shiga T, Miyazaki S, Kashiyama T, Akamatsu W, Saito M. Involvement of kallikrein-PAR2-proinflammatory pathway in severe trastuzumab-induced cardiotoxicity. Cancer Sci. 2022

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研究業績詳細

樫山 拓（カシヤマ タク）

樫山拓（カシヤマタク）