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櫻井隆（サクライタカシ）

研究テーマ	アルツハイマー病におけるアミロイドβ依存性病態進展機序の研究
研究業績（論文）	論文 CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis. Ikeda A, Meng H, Taniguchi D, Mio M, Funayama M, Nishioka K, Yoshida M, Li Y, Yoshino H, Inoshita T, Shiba-Fukushima K, Okubo Y, Sakurai T, Amo T, Aiba I, Saito Y, Saito Y, Murayama S, Atsuta N, Nakamura R, Tohnai G, Izumi Y, Morita M, Tamura A, Kano O, Oda M, Kuwabara S, Yamashita T, Sone J, Kaji R, Sobue G, Imai Y, Hattori N: PNAS Nexus 2024;3(8):pgae319. doi: 10.1093/pnasnexus/pgae319 An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice. Okabe Y, Murakoshi N, Kurebayashi N, Inoue H, Ito Y, Murayama T, Miyoshi C, Funato H, Ishii K, Xu D, Tajiri K, Qin R, Aonuma K, Murakata Y, Song Z, Wakana S, Yokoyama U, Sakurai T, Aonuma K, Ieda M, Yanagisawa M: Proc Natl Acad Sci U S A 2024;121(17):e2218204121. doi: 10.1073/pnas.2218204121 Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. Komai M, Noda Y, Ikeda A, Kaneshiro N, Kamikubo Y, Sakurai T, Uehara T, Takasugi N: J Lipid Res 2024;65(3):100510. doi: 10.1016/j.jlr.2024.100510 A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. Ishida R, Kurebayashi N, Iinuma H, Zeng X, Mori S, Kodama M, Murayama T, Masuno H, Takeda F, Kawahata M, Tanatani A, Miura A, Nishio H, Sakurai T, Kagechika H: Eur J Med Chem 2023;262:115910. doi: 10.1016/j.ejmech.2023.115910 Screening for novel RyR2 inhibitors by ER Ca2+ monitoring. Takenaka M, Kodama M, Murayama T, Ishigami-Yuasa M, Mori S, Ishida R, Suzuki J, Kanemaru K, Sugihara M, Iino M, Miura A, Nishio H, Morimoto S, Kagechika H, Sakurai T, Kurebayashi N: Mol Pharmacol 2023; 104(6):275-286. doi: 10.1124/molpharm.123.000720 Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage. Kamikubo Y, Jin H, Zhou Y, Niisato K, Hashimoto Y, Takasugi N, Sakurai T: Front Mol Neurosci 2023;15:1068990. doi: 10.3389/fnmol.2022.1068990 Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle. Okamoto K, Kamikubo Y, Yamauchi K, Okamoto S, Takahashi M, Ishida Y, Koike M, Ikegaya Y, Sakurai T, Hioki H: Sci Rep 2023;13:323. doi: 10.1038/s41598-022-27372-8 A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. Murayama T, Kurebayashi N, Numaga-Tomita T, Kobayashi T, Okazaki S, Yamashiro K, Nakada T, Mori S, Ishida R, Kagechika H, Yamada M, Sakurai T: J Gen Physiol 2022;154:e202213230. doi: 10.1085/jgp.202213230 Multifaceted analysis of nanotoxicity using primary cultured neurons. Kamikubo Y, Yamana T, Inoue Y, Sakurai T: Nano Ex 2022;3:035003. doi: 10.1088/2632-959X/ac7cfd Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Kobayashi T, Tsutsumi A, Kurebayashi N, Saito K, Kodama M, Sakurai T, Kikkawa M, Murayama T, Ogawa H: Nat Commun 2022; 13(1):2821. doi: 10.1038/s41467-022-30429-x. Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2. Kurebayashi N, Murayama T, Ota R, Suzuki J, Kanemaru K, Kobayashi T, Ohno S, Horie M, Iino M, Yamashita F, Sakurai T: J Gen Physiol 2022; 154(9):e202112869. doi: 10.1085/jgp.202112869. Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease. Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N: iScience 2022; 25(3):103869. doi: 10.1016/j.isci.2022.103869. Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome. Hirose S, Murayama T, Tetsuo N, Hoshiai M, Kise H, Yoshinaga M, Aoki H, Fukuyama M, Wuriyanghai Y, Wada Y, Kato K, Makiyama T, Kimura T, Sakurai T, Horie M, Kurebayashi N, Ohno S: Europace 2022; 24(3):497-510. doi: 10.1093/europace/euab250. Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. Komiya E, Tominaga M, Hatano R, Kamikubo Y, Toyama S, Sakairi H, Honda K, Itoh T, Kamata Y, Tsurumachi M, Kishi R, Ohnuma K, Sakurai T, Morimoto C, Takamori K: J Allergy Clin Immunol 2022; 149(3):1085-1096. doi: 10.1016/j.jaci.2021.08.003. A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Yamazawa T, Kobayashi T, Kurebayashi N, Konishi M, Noguchi S, Inoue T, Inoue YU, Nishino I, Mori S, Iinuma H, Manaka N, Kagechika H, Uryash A, Adams J, Lopez JR, Liu X, Diggle C, Allen PD, Kakizawa S, Ikeda K, Lin B, Ikemi Y, Nunomura K, Nakagawa S, Sakurai T, Murayama T: Nat Commun 2021; 12(1):4293. doi: 10.1038/s41467-021-24644-1. Conformational diversity of dynactin sidearm and domain organization of its subunit p150. Saito K, Murayama T, Hata T, Kobayashi T, Shibata K, Kazuno S, Fujimura T, Sakurai T, Toyoshima YY: Mol Biol Cell 2020; 31(12):1218-1231. doi: 10.1091/mbc.E20-01-0031. Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics. Yamazawa T, Ogawa H, Murayama T, Yamaguchi M, Oyamada H, Suzuki J, Kurebayashi N, Kanemaru K, Oguchi K, Sakurai T, Iino M: J Gen Physiol 2020; 152(1):e201812235. doi: 10.1085/jgp.201812235. G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals. Sakairi H, Kamikubo Y, Abe M, Ikeda K, Ichiki A, Tabata T, Kano M, Sakurai T: ACS Chem Neurosci 2020; 11(4):567-578. doi: 10.1021/acschemneuro.9b00599. Cerebellar neurodegeneration and neuronal circuit remodeling in Golgi pH regulator-deficient mice.:Sou YS, Kakuta S, Kamikubo Y, Niisato K, Sakurai T, Parajuli LK, Tanida I, Saito H, Suzuki N, Sakimura K, Maeda Y, Kinoshita T, Uchiyama Y, Koike M: eNeuro 2019; pii: ENEURO.0427-18.2019. doi: 10.1523/ENEURO.0427-18.2019. Induction of oxidative stress and cell death in neural cells by silica nanoparticles.: Kamikubo Y, Yamana T, Hashimoto Y, Sakurai T: ACS Chem Neurosci 2019; 10(1):304-312. doi: 10.1021/acschemneuro.8b00248. TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.: Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T.: PLoS ONE 2018;13: e0200988.

研究テーマ

アルツハイマー病におけるアミロイドβ依存性病態進展機序の研究

研究業績（論文）

論文
CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis. Ikeda A, Meng H, Taniguchi D, Mio M, Funayama M, Nishioka K, Yoshida M, Li Y, Yoshino H, Inoshita T, Shiba-Fukushima K, Okubo Y, Sakurai T, Amo T, Aiba I, Saito Y, Saito Y, Murayama S, Atsuta N, Nakamura R, Tohnai G, Izumi Y, Morita M, Tamura A, Kano O, Oda M, Kuwabara S, Yamashita T, Sone J, Kaji R, Sobue G, Imai Y, Hattori N: PNAS Nexus 2024;3(8):pgae319. doi: 10.1093/pnasnexus/pgae319

An inherited life-threatening arrhythmia model established by screening randomly mutagenized mice. Okabe Y, Murakoshi N, Kurebayashi N, Inoue H, Ito Y, Murayama T, Miyoshi C, Funato H, Ishii K, Xu D, Tajiri K, Qin R, Aonuma K, Murakata Y, Song Z, Wakana S, Yokoyama U, Sakurai T, Aonuma K, Ieda M, Yanagisawa M: Proc Natl Acad Sci U S A 2024;121(17):e2218204121. doi: 10.1073/pnas.2218204121

Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes. Komai M, Noda Y, Ikeda A, Kaneshiro N, Kamikubo Y, Sakurai T, Uehara T, Takasugi N: J Lipid Res 2024;65(3):100510. doi: 10.1016/j.jlr.2024.100510

A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. Ishida R, Kurebayashi N, Iinuma H, Zeng X, Mori S, Kodama M, Murayama T, Masuno H, Takeda F, Kawahata M, Tanatani A, Miura A, Nishio H, Sakurai T, Kagechika H: Eur J Med Chem 2023;262:115910. doi: 10.1016/j.ejmech.2023.115910

Screening for novel RyR2 inhibitors by ER Ca2+ monitoring. Takenaka M, Kodama M, Murayama T, Ishigami-Yuasa M, Mori S, Ishida R, Suzuki J, Kanemaru K, Sugihara M, Iino M, Miura A, Nishio H, Morimoto S, Kagechika H, Sakurai T, Kurebayashi N: Mol Pharmacol 2023; 104(6):275-286. doi: 10.1124/molpharm.123.000720

Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage. Kamikubo Y, Jin H, Zhou Y, Niisato K, Hashimoto Y, Takasugi N, Sakurai T: Front Mol Neurosci 2023;15:1068990. doi: 10.3389/fnmol.2022.1068990

Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle. Okamoto K, Kamikubo Y, Yamauchi K, Okamoto S, Takahashi M, Ishida Y, Koike M, Ikegaya Y, Sakurai T, Hioki H: Sci Rep 2023;13:323. doi: 10.1038/s41598-022-27372-8

A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery. Murayama T, Kurebayashi N, Numaga-Tomita T, Kobayashi T, Okazaki S, Yamashiro K, Nakada T, Mori S, Ishida R, Kagechika H, Yamada M, Sakurai T: J Gen Physiol 2022;154:e202213230. doi: 10.1085/jgp.202213230

Multifaceted analysis of nanotoxicity using primary cultured neurons. Kamikubo Y, Yamana T, Inoue Y, Sakurai T: Nano Ex 2022;3:035003. doi: 10.1088/2632-959X/ac7cfd

Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Kobayashi T, Tsutsumi A, Kurebayashi N, Saito K, Kodama M, Sakurai T, Kikkawa M, Murayama T, Ogawa H: Nat Commun 2022; 13(1):2821. doi: 10.1038/s41467-022-30429-x.

Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2. Kurebayashi N, Murayama T, Ota R, Suzuki J, Kanemaru K, Kobayashi T, Ohno S, Horie M, Iino M, Yamashita F, Sakurai T: J Gen Physiol 2022; 154(9):e202112869. doi: 10.1085/jgp.202112869.

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease. Kaneshiro N, Komai M, Imaoka R, Ikeda A, Kamikubo Y, Saito T, Saido TC, Tomita T, Hashimoto T, Iwatsubo T, Sakurai T, Uehara T, Takasugi N: iScience 2022; 25(3):103869. doi: 10.1016/j.isci.2022.103869.

Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome. Hirose S, Murayama T, Tetsuo N, Hoshiai M, Kise H, Yoshinaga M, Aoki H, Fukuyama M, Wuriyanghai Y, Wada Y, Kato K, Makiyama T, Kimura T, Sakurai T, Horie M, Kurebayashi N, Ohno S: Europace 2022; 24(3):497-510. doi: 10.1093/europace/euab250.

Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. Komiya E, Tominaga M, Hatano R, Kamikubo Y, Toyama S, Sakairi H, Honda K, Itoh T, Kamata Y, Tsurumachi M, Kishi R, Ohnuma K, Sakurai T, Morimoto C, Takamori K: J Allergy Clin Immunol 2022; 149(3):1085-1096. doi: 10.1016/j.jaci.2021.08.003.

A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Yamazawa T, Kobayashi T, Kurebayashi N, Konishi M, Noguchi S, Inoue T, Inoue YU, Nishino I, Mori S, Iinuma H, Manaka N, Kagechika H, Uryash A, Adams J, Lopez JR, Liu X, Diggle C, Allen PD, Kakizawa S, Ikeda K, Lin B, Ikemi Y, Nunomura K, Nakagawa S, Sakurai T, Murayama T: Nat Commun 2021; 12(1):4293. doi: 10.1038/s41467-021-24644-1.

Conformational diversity of dynactin sidearm and domain organization of its subunit p150. Saito K, Murayama T, Hata T, Kobayashi T, Shibata K, Kazuno S, Fujimura T, Sakurai T, Toyoshima YY: Mol Biol Cell 2020; 31(12):1218-1231. doi: 10.1091/mbc.E20-01-0031.

Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics. Yamazawa T, Ogawa H, Murayama T, Yamaguchi M, Oyamada H, Suzuki J, Kurebayashi N, Kanemaru K, Oguchi K, Sakurai T, Iino M: J Gen Physiol 2020; 152(1):e201812235. doi: 10.1085/jgp.201812235.

G Protein-Coupled Glutamate and GABA Receptors Form Complexes and Mutually Modulate Their Signals. Sakairi H, Kamikubo Y, Abe M, Ikeda K, Ichiki A, Tabata T, Kano M, Sakurai T: ACS Chem Neurosci 2020; 11(4):567-578. doi: 10.1021/acschemneuro.9b00599.

Cerebellar neurodegeneration and neuronal circuit remodeling in Golgi pH regulator-deficient mice.:Sou YS, Kakuta S, Kamikubo Y, Niisato K, Sakurai T, Parajuli LK, Tanida I, Saito H, Suzuki N, Sakimura K, Maeda Y, Kinoshita T, Uchiyama Y, Koike M: eNeuro 2019; pii: ENEURO.0427-18.2019. doi: 10.1523/ENEURO.0427-18.2019.

Induction of oxidative stress and cell death in neural cells by silica nanoparticles.: Kamikubo Y, Yamana T, Hashimoto Y, Sakurai T: ACS Chem Neurosci 2019; 10(1):304-312. doi: 10.1021/acschemneuro.8b00248.

TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.: Takasugi N, Araya R, Kamikubo Y, Kaneshiro N, Imaoka R, Jin H, Kashiyama T, Hashimoto Y, Kurosawa M, Uehara T, Nukina N, Sakurai T.: PLoS ONE 2018;13: e0200988.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

櫻井 隆（サクライ タカシ）

櫻井隆（サクライタカシ）