学校法人順天堂　研究者情報データベース:::研究業績詳細:::

HOME　＞　研究業績詳細

研究業績詳細

染谷明正（ソメヤアキマサ）

研究テーマ	細胞老化の分子メカニズム解明
研究業績（論文）	論文　(英文) Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells. Yamazaki S、Yamaguchi K、Someya A、Nagaoka I、Hayashida M. Int J Mol Sci 23: Doi：10.3390/ijms231710096, 2022. Human Cathelicidin Peptide LL-37 Induces Cell Death in Autophagy-Dysfunctional Endothelial Cells. Suzuki K、Ohkuma M、Someya A、Mita T、Nagaoka I. J Immunol 208:2163-2172, 2022. Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells. Mijiti N、Someya A、Nagaoka I. Exp Ther Med 2：doi: 10.3892/etm.2021.10735 Citrulline cooperatively exerts an anti‑inflammatory effect on synovial cells with glucosamine and N‑acetylglucosamine. Yamagishi Y、Someya A、Nagaoka I. Biomed Rep 1：37-42, 2020. Yokukansan, a Japanese Herbal Medicine, suppresses Substance P-induced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells. Yamaguchi K、Yamasaki S、Kumakura S、Someya A、Iseki M、Inada E、Nagaoka I. Endocr Metab Immune Disord Drug Targets 20:1073-1080, 2020. I Anti inflammatory actions of gabapentin and pregabalin on the substance P induced mitogen activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells. Yamaguchi K, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I. Mol Med Rep. doi: 10.3892/mmr.2017.7368, 2017. Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells. Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I: Mol Med Rep, doi:10.3892/mmr.4310.2017, 2017. Evaluation of the effect of oral administration of collagen peptides on an experimental rat osteoarthritis model. Isaka S, Someya A, Nakamura S, Naito K, Nozawa M, Inoue N, Sugihara F, Nagaoka I, Kaneko K: Exp Ther Med 13: 2699-2706, 2017. Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG astrocytoma cells. Yamaguchi K, Kumakura S, Murakami T, Someya A, Inada E, Nagaoka I: Int J Mol Med. 2017 Mar;39(3):687-692. doi: 10.3892/ijmm, 2017. Glucosamine downregulates the IL-1β induced expression of proinflammatory cytokine genes in human synovial MH7A cells by O-GlcNAc modification-dependent and -independent mechanisms. Someya A, Ikegami T, Sakamoto K, Nagaoka I. PLOS One 11(10): e0165158,doi:10.1371/journal.pone.0165158, 2016. The relationship between the preoperative transition of serum anticholinergic activity and postoperative delirium in patients undergoing esophagectomy and gastrectomy.　 Kitajima Y, Yamaguchi K, Hori K, Murakami T, Someya A, Konishi K, Hara A, Hachisu M, Kajiyama Y, Nagaoka I, Inada E. Juntendo Med J 60: 147-150, 2014. Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy. Wakabayashi S, Yamaguchi K, Kumakura S, Murakami M, Someya A, Kajiyama Y, Nagaoka I, Inada E.　 Int. J. Mol. Med. 34: 137-144, 2014. GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells. Hu Z, Du J, Yang L, Zhu Y, Yang Y, Zheng D, Someya A, Gu L, Lu X. PLoS One 7:e38777, 2012.　Doi: 10.1371 The guanine nucleotide-exchange protein for ADP-ribosylation factor 6, ARF-GEP100/BRAG2 regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process. Someya A, Moss J, Nagaoka I J Biol Chem 285: 30698-30707, 2010. Evaluation of the expression and enzyme activity of matrix metalloproteinase-7 in fetal membranes during premature rupture of membranes at term in humans. Nishihara S, Someya A, Yomemoto H, Ota A, Itoh S, Nagaoka I, Takeda S. Reprod. Sci. 15(2):156-165, 2008. Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. Murakami T, Yomogida S, Someya A, Kuwahara-Arai K, Tamura H, Nagaoka I. FEBS Lett. 581(1) 140-144, 2007. Changes in matrix metalloproteinase 2 activities in amniochorions during premature rupture of membranes. Ota A, Yomemoto H, Someya A, Itoh S, Kinoshita K, Nagaoka I. J Soc Gynecol Investig.13(8): 592-7. 2006 Involvement of a guanine nucleotide-exchange protein, ARF-GEP100/BRAG2a, in the apoptotic cell death of monocytic phagocytes. Someya A, Moss J Nagaoka I. J Leukoc Biol. 80: 915-921, 2006 GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin. Hiroi T, Someya A, Thompson W, Moss J, Vaughan M. Proc Natl Acad Sci U S A. 103(28):10672-7, 2006 総説グルコサミンの抗炎症作用についてのメカニズム. 染谷明正, 坂本廣司, 長岡　功.　キチン・キトサン研究 25(1), 31-39, 2019. グルコサミンによる滑膜炎症の分子制御メカニズム. 染谷明正, 坂本廣司, 長岡　功. 日本未病システム学会雑誌19 (1): 111-115, 2013. 滑膜細胞の遺伝子発現に対するグルコサミンの影響. 染谷明正, 坂本廣司, 長岡　功. グルコサミン研究 8: 24-32, 2012. Someya A, Nagaoka I: Role of ARF-GEP100, a guanine nucleotide-exchange protein fro ADP-ribosylation factor in macrophage phagocytosis..Inflammation Regeneration 30: 48-54, 2010. グアニンヌクレオチド交換タンパク質 (guanine nucleotide-exchange protein; GEP)によるマクロファージ様細胞のアポトーシス誘導. 染谷明正, Moss Joel, Vaughan Martha, 長岡　功. Inframmation and Regeneration 26　(2), 107-112, 2006.

研究テーマ

細胞老化の分子メカニズム解明

研究業績（論文）

論文　(英文)
Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells. Yamazaki S、Yamaguchi K、Someya A、Nagaoka I、Hayashida M. Int J Mol Sci 23: Doi：10.3390/ijms231710096, 2022.

Human Cathelicidin Peptide LL-37 Induces Cell Death in Autophagy-Dysfunctional Endothelial Cells. Suzuki K、Ohkuma M、Someya A、Mita T、Nagaoka I. J Immunol 208:2163-2172, 2022.

Effects of isoflavone derivatives on the production of inflammatory cytokines by synovial cells. Mijiti N、Someya A、Nagaoka I. Exp Ther Med 2：doi: 10.3892/etm.2021.10735

Citrulline cooperatively exerts an anti‑inflammatory effect on synovial cells with glucosamine and N‑acetylglucosamine. Yamagishi Y、Someya A、Nagaoka I. Biomed Rep 1：37-42, 2020.

Yokukansan, a Japanese Herbal Medicine, suppresses Substance P-induced Production of Interleukin-6 and Interleukin-8 by Human U373 MG Glioblastoma Astrocytoma Cells. Yamaguchi K、Yamasaki S、Kumakura S、Someya A、Iseki M、Inada E、Nagaoka I. Endocr Metab Immune Disord Drug Targets 20:1073-1080, 2020. I

Anti inflammatory actions of gabapentin and pregabalin on the substance P induced mitogen activated protein kinase activation in U373 MG human glioblastoma astrocytoma cells. Yamaguchi K, Kumakura S, Someya A, Iseki M, Inada E, Nagaoka I. Mol Med Rep. doi: 10.3892/mmr.2017.7368, 2017.

Evaluation of the anti-inflammatory actions of various functional food materials including glucosamine on synovial cells. Yamagishi Y, Someya A, Imai K, Nagao J, Nagaoka I: Mol Med Rep, doi:10.3892/mmr.4310.2017, 2017.

Evaluation of the effect of oral administration of collagen peptides on an experimental rat osteoarthritis model. Isaka S, Someya A, Nakamura S, Naito K, Nozawa M, Inoue N, Sugihara F, Nagaoka I, Kaneko K: Exp Ther Med 13: 2699-2706, 2017.

Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG astrocytoma cells. Yamaguchi K, Kumakura S, Murakami T, Someya A, Inada E, Nagaoka I: Int J Mol Med. 2017 Mar;39(3):687-692. doi: 10.3892/ijmm, 2017.

Glucosamine downregulates the IL-1β induced expression of proinflammatory cytokine genes in human synovial MH7A cells by O-GlcNAc modification-dependent and -independent mechanisms. Someya A, Ikegami T, Sakamoto K, Nagaoka I. PLOS One 11(10): e0165158,doi:10.1371/journal.pone.0165158, 2016.

The relationship between the preoperative transition of serum anticholinergic activity and postoperative delirium in patients undergoing esophagectomy and gastrectomy.　 Kitajima Y, Yamaguchi K, Hori K, Murakami T, Someya A, Konishi K, Hara A, Hachisu M, Kajiyama Y, Nagaoka I, Inada E. Juntendo Med J 60: 147-150, 2014.

Effects of anesthesia with sevoflurane and propofol on the cytokine/chemokine production at the airway epithelium during esophagectomy. Wakabayashi S, Yamaguchi K, Kumakura S, Murakami M, Someya A, Kajiyama Y, Nagaoka I, Inada E.　 Int. J. Mol. Med. 34: 137-144, 2014.

GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells. Hu Z, Du J, Yang L, Zhu Y, Yang Y, Zheng D, Someya A, Gu L, Lu X. PLoS One 7:e38777, 2012.　Doi: 10.1371

The guanine nucleotide-exchange protein for ADP-ribosylation factor 6, ARF-GEP100/BRAG2 regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process. Someya A, Moss J, Nagaoka I J Biol Chem 285: 30698-30707, 2010.

Evaluation of the expression and enzyme activity of matrix metalloproteinase-7 in fetal membranes during premature rupture of membranes at term in humans. Nishihara S, Someya A, Yomemoto H, Ota A, Itoh S, Nagaoka I, Takeda S. Reprod. Sci. 15(2):156-165, 2008.

Antibacterial cathelicidin peptide CAP11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes. Murakami T, Yomogida S, Someya A, Kuwahara-Arai K, Tamura H, Nagaoka I. FEBS Lett. 581(1) 140-144, 2007.

Changes in matrix metalloproteinase 2 activities in amniochorions during premature rupture of membranes. Ota A, Yomemoto H, Someya A, Itoh S, Kinoshita K, Nagaoka I. J Soc Gynecol Investig.13(8): 592-7. 2006

Involvement of a guanine nucleotide-exchange protein, ARF-GEP100/BRAG2a, in the apoptotic cell death of monocytic phagocytes. Someya A, Moss J Nagaoka I. J Leukoc Biol. 80: 915-921, 2006

GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin. Hiroi T, Someya A, Thompson W, Moss J, Vaughan M. Proc Natl Acad Sci U S A. 103(28):10672-7, 2006

総説
グルコサミンの抗炎症作用についてのメカニズム. 染谷明正, 坂本廣司, 長岡　功.　キチン・キトサン研究 25(1), 31-39, 2019.

グルコサミンによる滑膜炎症の分子制御メカニズム. 染谷明正, 坂本廣司, 長岡　功. 日本未病システム学会雑誌19 (1): 111-115, 2013.

滑膜細胞の遺伝子発現に対するグルコサミンの影響. 染谷明正, 坂本廣司, 長岡　功. グルコサミン研究 8: 24-32, 2012.

Someya A, Nagaoka I: Role of ARF-GEP100, a guanine nucleotide-exchange protein fro ADP-ribosylation factor in macrophage phagocytosis..Inflammation Regeneration 30: 48-54, 2010.

グアニンヌクレオチド交換タンパク質 (guanine nucleotide-exchange protein; GEP)によるマクロファージ様細胞のアポトーシス誘導. 染谷明正, Moss Joel, Vaughan Martha, 長岡　功. Inframmation and Regeneration 26　(2), 107-112, 2006.

研究者

教育活動

【学校法人順天堂】研究者情報データベース

研究業績詳細

染谷 明正（ソメヤ アキマサ）

染谷明正（ソメヤアキマサ）