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研究業績詳細

赤澤 智宏（アカザワ チヒロ）

研究テーマ 再生医療、神経科学、マイクロバイオーム、研究支援
研究業績（論文） [2024]
1. Hisamatsu D, Ikeba A, Yamato T, Mabuchi Y, Watanabe M, Akazawa C*. Optimization of transplantation methods using isolated mesenchymal stem/stromal cells: clinical trials of inflammatory bowel diseases as an example. Inflamm Regen. 2024 Aug 16;44(1):37. doi: 10.1186/s41232-024-00350-5.PMID: 39152520
2. Yamazaki S, Mabuchi Y, Kimura T, Suto EG, Hisamatsu D, Naraoka Y, Kondo A, Azuma Y, Kikuchi R, Nishikii H, Morishita S, Araki M, Komatsu N, Akazawa C. Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling. Stem Cell Rep. 2024 Mar 12;19(3):414-425. doi: 10.1016/j.stemcr.2024.02.002. Epub 2024 Feb 29.PMID: 38428413
3. Naraoka Y, Mabuchi Y, Kiuchi M, Kumagai K, Hisamatsu D, Yoneyama Y, Takebe T, Akazawa C. Quality Control of Stem Cell-Based Cultured Meat According to Specific Differentiation Abilities. Cells. 2024 Jan 11;13(2):135. doi: 10.3390/cells13020135.PMID: 3824782
[2023]
4. Nakazawa-Tanaka N, Fujiwara N, Miyahara K, Akazawa C, Urao M, Yamataka A. The impact of the recipient intestinal site on the differentiation of transplanted enteric neural crest cells. Pediatr Surg Int. 2023 Nov 20;39(1):297. doi: 10.1007/s00383-023-05587-8.PMID: 37982909.
5. Fujiwara N, Miyahara K, Lee D, Nakazawa-Tanaka N, Akazawa C, Hatano M, Pierro A, Yamataka A. A novel mouse model of intestinal neuronal dysplasia: visualization of the enteric nervous system. Pediatr Surg Int. 2023 Nov 20;39(1):298. doi: 10.1007/s00383-023-05585-w.PMID: 37982893
6. Ishida Y, Mabuchi Y, Naraoka Y, Hisamatsu D, Akazawa C. Conservation of markers and stemness in adipose stem and progenitor cells between cattle and other species. Int. J. Mol. Sci. 2023, 24(15), 11908; doi: 10.3390/ijms241511908.PMID: 37569284
7. Yamashita Y, Nakada S, Nakamura K, Sakurai H, Ohno K, Goto T, Mabuchi Y, Akazawa C, Hattori N, Arikawa-Hirasawa E. Evaluation of human-Induced pluripotent stem cells derived from a patient with Schwartz–Jampel syndrome revealed distinct hyperexcitability in the skeletal muscles. Biomedicines. 2023 Mar 7;11(3):814. doi: 10.3390/biomedicines11030814.PMID: 36979792
8. Hisamatsu D, Itakura N, Mabuchi Y, Ozaki R, Grace Suto E, Naraoka Y, Ikeda A, Ito L, Akazawa C. CD73-positive cell spheroid transplantation attenuates colonic atrophy. Pharmaceutics. 2023 Mar 4;15(3):845. doi: 10.3390/pharmaceutics15030845.PMID: 36986706
9. Utagawa K, Shin T, Yamada H, Ochi H, Sunamura S, Unno A, Akazawa C, Ema M, Takeda S, Okawa A, Sato S. Three-dimensional visualization of neural networks inside bone by Osteo-DISCO protocol and alteration of bone remodeling by surgical nerve ablation. Sci Rep. 2023 Mar 22;13(1):4674. doi: 10.1038/s41598-023-30492-4.PMID: 36949102
[2022]
10. Nakazawa-Tanaka N, Fujiwara N, Miyahara K, Akazawa C, Urano M, Yamataka A. Increased enteric neural crest cell differentiation after transplantation into aganglionic mous gut. Pediatr Surg Int. 2022 Dec 1;39(1)29. doi: 10.1007/s00383-022-05324-7. PMID: 36454299
11. Hisamatsu D, Ikeda A, Ito L, Matsushita Y, Hiki M, Mori H, Tabe Y, Naito T, Akazawa C*. Longitudinal analyses after COVID-19 recovery or prolonged infection reveal unique immunological signatures after repeated vaccinations. Vaccines. 2022, 10, 1815. https://doi.org/10.3390/caccines 1011815
12. Kanazawa S, Okada H, Riu D, Mabuchi Y, Akazawa C Iwata J, Hoshi K, Hikita A. Hematopoitetic-mesenchymal signals regulate the properties of mesenchymal stem cells. Int J Mol Sci. 2022 Jul 26;23(15):8238. doi: 10.3390/ijms23158238.PMID: 35897814
13. Fujiwara N, Miyahara K, Nakazawa-Tanaka N, Akazawa C, Yamataka A. In vitro investigation of the differentiation of enteric neural crest-derived cells following transplantation of aganglionic gut in a mouse model. Pediatr Surg Int. 2022 May;38(5):755-759. doi:10.1007/s00383-022-05105-2. Epub 2022 Mar 2.PMID: 35235011
[2021]
14. Suzuki H, Furuya J, Hidaka R, Miyajima S, Matsubara C, Ohwada G, Asada T, Akazawa C, Sato Y, Tohara H, Minakuchi S. Patients with mild cognitive impairment diagnosed at dementia clinic display decreased maximum occlusal force: a cross-sectional study. BMC Oral Health. 2021 Dec 27;21(1):665. doi: 10.1186/s12903-021-02027-8.PMID: 34961506
15. Ohyagi M, Nagata T, Ihara K, Yoshida-Tanaka K, Nishi N, Miyata H, Abe A, Mabuchi Y, Akazawa C, Yokota T. DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo. Nature Comm. 2021 Dec 22;12(1):7344. doi.org/10.1038/s41467-021-26902-8. PMID: 34937876
16. Naraoka Y, Mabuchi Y, Yoneyama Y, Suto EG, Hisamatsu D, Ikeda M, Ito R, Nakamura T, Takebe T, Akazawa C*. Isolation of tissue resident CD29-positive progenitor cells in livestock to generate a three-dimensional meat bud. Cells. 2021 Sept 21;10(9):2499. doi: 10.3390/cells10092499. PMID: 34572147
17. Mabuchi Y, Okawara C, Mendez-Ferrer S, Akazawa C*. Cellular heterogeneity of mesenchymal stem/stromal cells in the bone marrow. Frontiers in Cell and Developmental Biology. 2021 Jul 6;9:689366. doi: 10.3389/fcell.2021.689366. eCollection 2021.　PMID: 34295894
18. Yamazaki M, Sugimoto K, Mabuchi Y, Yamashita R, Ichikawa-Tomikawa N, Kaneko T, Akazawa C, Hasegawa H, Imura T, Chiba H. Soluble JAM-C Ectodomain Serves as the Niche for Adipose-Derived Stromal/Stem Cells. Biomedicines. 2021 Mar 10;9(3):278. doi: 10.3390/biomedicines9030278. PMID: 33801826
19. Wakita M, Idei M, Saito K, Horiuchi Y, Yamatani K, Ishikawa S, Yamamoto T, Igawa G, Hinata M, Kadota K, Kurosawa T, Takahashi S, Saito T, Misawa S, Akazawa C, Naito T, Miida T, Takahashi K, Ai T, Tabe Y. Comparison of the clinical performance and usefulness of five SARS-Cov-2 antibody tests. PLoS One. 2021 Feb 8;16(2):e0246536. doi: 15.1371/journal.pone.0246536. eCollection 2021.PMID: 33556086
20. Harada S, Mabuchi Y, Kohyama J, Shimojo D, Suzuki S, Kawamura Y, Araki D, Suyama T, Kajikawa M, Akazawa C, Okano H, Matsuzaki Y. FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells. Stem Cells. 2021 Mar;39(3):318-330. doi: 10.1002/stem.3317. PMID: 33338299
[2020]
21. Suto EG, Mabuchi Y, Toyota S, Taguchi M, Naraoka Y, Itakura N, Matsuoka Y, Fujii Y, Miyasaka N, Akazawa C*. Advantage of fat-derived CD73 positive cells from multiple human tissues, prospective isolated mesenchymal stromal cells. Sci Rep. 2020 Sept 15;10:15073. doi: 10.1038/s41598-020-72012-8. PMID: 32934322
22. Hayashi C, Suzuki N, Takahashi R, Akazawa C*. Development of type I/II oligodendrocytes regulated by teneurin-4 in the murine spinal cord. Sci Rep. 2020 May 25;10(1):8611. doi: 10.1038/s41598-020-65485-0. PMID: 32451386
23. Kodaka M, Mao F, Arimoto-Matsuzaki K, Kitamura M, Xu X, Yang Z, Nakagawa K, Maruyama J, Ishii K, Akazawa C, Oyaizu T, Yamamoto N, Ishigami-Yuasa M, Tsuemoto N, Ito S, Kagechika H, Nishina H, Hata Y. Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells. PLoS One. 2020 Apr 8;15(4):e0231265. doi: 10.1371/journal.pone.0231265. eCollection 2020.　PMID: 32267872.
24. Hayashi C, Suzuki N, Mabuchi Y, Kikura N, Hosoda Y, de Vega S, Akazawa C*. The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation. Biochem Biophys Res Commun. 2020 Feb 26;523(1):171-176. doi: 10.1016/j.bbrc.2019.12.002. Epub 2019 Dec 13. PMID:31839217
[1019]
25. Suzuki N, Hyodo M, Hayashi C, Mabuchi Y, Sekimoto K, Onchi C, Sekiguchi K, Akazawa C*. Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells. Sci Rep. 2019 Dec 27;9(1):19882. doi: 10.1038/s41598-019-56488-7. PMID: 31882770
26. Nakazawa-Tanaka N, Miyahara K, Fujiwara N, Ochi T, Sueyoshi R, Nojiri S, Akazawa C, Urao M, Yamataka A. Decreased expression of b1 integrin in enteric neural crest cells of the endothelin receptor B null mouse model. Pediatr Surg Int. 2019 Oct 1. doi: 10.1007/s00383-019-04578-y. PMID: 31576467
27. Ouchi R, Togo S, Kimura M, Shinozawa T, Koido M, Koike H, Thompson W, Karns RA, Mayhew CN, McGrath PS, McCauley HA, Zhang RR, Lewis K, Hakozaki S, Ferguson A, Saiki N, Yoneyama Y, Takeuchi I, Mabuchi Y, Akazawa C, Yoshikawa HY, Wells JM, Takebe T. Modeling steatohepatitis in humans with pluripotent stem cell-derived organoids. Cell Metab. 2019 May 14. pii: S1550-4131(19)30247-5. doi: 12.1016/j.cmet.2019.05.007. PMID: 31155493
28. Shibata S, Iseda T, Mitsuhashi T, Oka A, Shindo T, Moritoki N, Nagai T, Otsubo S, Inoue T, Sasaki E, Akazawa C, Takahashi T, Schalek R, Lichtman JW, Okano H. Large-area fluorescence and electron microscopic correlative imaging with multibeam scanning electron microscopy. Front Neural Circuits. 2019 May 8;13:29. doi: 10.3389/fncir.2019.00029. eCollection 2019. PMID: 31133819
29. Supakul S, Yao K, Ochi H, Shimada T, Hashimoto K, Sunamura S, Mabuchi Y, Tanaka M, Akazawa C, Nakamura T, Okawa A, Takeda S, Sato S. Pericytes as a source of osteogenic cells in bone fracture healing. Int J Mol Sci. 2019 Mar 2;20(5). pii: E1079. doi: 10.3390/ijms20051079. PMID: 30832329
[2018]
30. Ogata Y, Mabuchi Y, Shinoda K, Horiike Y, Mizuno M, Otabe K, Suto EG, Suzuki N, Sekiya I, Akazawa C*. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage. Regenerative Therapy. 2018. vol 8, 20-28. doi: 10.1016/j.reth.2017.12.001. PMID: 30271862
31. Sullivan S, Stacey GN, Akazawa C, Aoyama N, Baptista R, Bedford P, Bennaceur Griscelli A, Chandra A, Elwood N, Girard M, Kawamata S, Hanatani T, Latsis T, Lin S, Ludwig TE, Malygina T, Mack A, Mountford JC, Noggle S, Pereira LV, Price J, Sheldon M, Srivastava A, Stachelscheid H, Velayudhan SR, Ward NJ, Turner ML, Barry J, Song J. Quality control guidelines for clinical-grade human induced pluripotent stem cell lines. Regen Med. 2018 Oct;13(7):859-866. doi: 10.2217/rme-2018-0095. PMID: 30205750
32. Mizuno M, Katano H, Mabuchi Y, Ogata Y, Ichinose S, Fujii S, Otabe K, Komori K, Ozeki N, Koga H, Tsuji K, Akazawa C, Muneta T, Sekiya I. Specific markers and properties of synovial mesenchymal stem cells in the surface, stromal, and perivascular regions. Stem Cell Res Ther. 2018 May 2;9(1):123. doi: 10.1186/s13287-018-0870-9. PMID: 29720268
33. Hashimoto K, Ochi H, Sunamura S, Fukuda T, Yao K, Mabuchi Y, Okawa A, Akazawa C, Futakuchi M, Takeda S, Sato S. Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A. Proc Natl Acad Sci U S A. 2018 Feb 12. pii: 201717363. doi: 10.1073/pnas.1717363115. PMID: 29440427
34. Ishii K, Sakurai H, Suzuki N, Mabuchi Y, Skiya I, Sekiguchi K, Akazawa C*. Recapitulation of extracellular LAMININ environment maintains stemness of satellite cells in vitro. Stem Cell Rep. 2018 Jan 10. pii: S2213-6711(17)30561-1. doi: 10.1016/j.stemcr.2017.12.013. PMID: 29337118
35. Nakazawa-Tanaka N, Fujiwara N, Miyahara K, Nakada S, Arikawa-Hirasawa E, Akazawa C, Urano M, Yamataka A. The effect of laminin-1 on enteric neural crest-derived cell migration in the Hirschsprung’s disease mouse model. Pediatr Surg Int. 2018 Feb;34(2):143-147. doi: 10.1007/s00383-017-4181-5. PMID: 29018955
36. Fujiwara N, Nakazawa-Tanaka N, Miyahara K, Arikawa-Hirasawa E, Akazawa C, Yamataka A. Altered expression of laminin alpha1 in aganglionic colon of endothelin receptor-B null mouse model of Hirschsprung’s disease. Pediatr Surg Int. 2018 Feb;34(2):137-141. doi: 110.1007/s00383-017-4180-6. PMID: 28983681
37. Ogata Y, Mabuchi Y, Shinoda K, Horiike Y, Mizuno M, Otabe K, Suto EG, Suzuki N, Sekiya I, Akazawa C*. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage. Regenerative Therapy. 2018. vol 8, 20-28. doi: 10.1016/j.reth.2017.12.001. eCollection 2018 Jun.PMID: 30271862

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