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研究業績詳細

土師 正太郎（ハジ ショウタロウ）

研究テーマ パーキンソン病・筋萎縮性側索硬化症における画像バイオマーカーの開発、メタ解析を用いたエビデンス確立
研究業績（論文） 1: Haji S, Sako W, Hanada K, Matsubara T, Osaki Y, Matsumoto Y, Harada M, Izumi
Y. Magnetic Susceptibility and Area in the Subthalamic Nucleus Measured by QSM
for Diagnosis of Progressive Supranuclear Palsy. Mov Disord Clin Pract. 2025 May
29. doi: 10.1002/mdc3.70153. Epub ahead of print. PMID: 40439086.

2: Osaki Y, Nodera H, Sato R, Haji S, Fujita K, Miyamoto R, Muto K, Yamazaki H,
Morino H, Kanda T, Murayama S, Kaji R, Izumi Y. Peripheral nerve excitability
abnormalities in Neuronal Intranuclear Inclusion Disease: Assessment with
histopathological analysis. Clin Neurophysiol. 2025 Feb;170:156-167. doi:
10.1016/j.clinph.2024.12.013. Epub 2024 Dec 14. PMID: 39724790.

3: Nakamura K, Fujita K, Suzuki M, Kunugi A, Hirozane Y, Kunikata T, Takahashi
B, Narazaki G, Kondo H, Haji S, Hirai K, Izumi Y. Neuroinflammation and
glycosylation-related cerebrospinal fluid proteins for predicting functional
decline in amyotrophic lateral sclerosis: a proteomic study. Front Neurol. 2024
Nov 18;15:1418320. doi: 10.3389/fneur.2024.1418320. PMID: 39624674; PMCID:
PMC11608993.

4: Imamura K, Izumi Y, Egawa N, Ayaki T, Nagai M, Nishiyama K, Watanabe Y,
Murakami T, Hanajima R, Kataoka H, Kiriyama T, Nanaura H, Sugie K, Hirayama T,
Kano O, Nakamori M, Maruyama H, Haji S, Fujita K, Atsuta N, Tatebe H, Tokuda T,
Takahashi N, Morinaga A, Tabuchi R, Oe M, Kobayashi M, Lobello K, Morita S,
Sobue G, Takahashi R, Inoue H. Protocol for a phase 2 study of bosutinib for
amyotrophic lateral sclerosis using real-world data: induced pluripotent stem
cell-based drug repurposing for amyotrophic lateral sclerosis medicine (iDReAM)
study. BMJ Open. 2024 Oct 26;14(10):e082142. doi: 10.1136/bmjopen-2023-082142.
PMID: 39461864; PMCID: PMC11529471.

5: Hanada K, Osaki Y, Miyamoto R, Muto K, Haji S, Nazere K, Kuwano Y, Morino H,
Azuma Y, Miyatake S, Matsumoto N, Izumi Y. Intermediate phenotype between CMT2Z
and DIGFAN associated with a novel MORC2 variant: a case report. Hum Genome Var.
2024 Aug 15;11(1):29. doi: 10.1038/s41439-024-00287-8. PMID: 39143067; PMCID:
PMC11324651.

6: Haji S, Sako W, Murakami N, Osaki Y, Izumi Y. Factors associated with a
placebo effect in Parkinson's disease in clinical trials: a meta-analysis. J
Neurol. 2024 Sep;271(9):5825-5837. doi: 10.1007/s00415-024-12529-4. Epub 2024
Jul 2. PMID: 38955829.

7: Yamamoto Y, Fujita K, Yamazaki H, Haji S, Osaki Y, Izumi Y. Constipation in
patients with motor neuron disease: A retrospective longitudinal study. Heliyon.
2024 Mar 13;10(6):e27951. doi: 10.1016/j.heliyon.2024.e27951. PMID: 38524582;
PMCID: PMC10957436.

8: Haji S, Miyamoto R, Morino H, Osaki Y, Tsuji S, Nishino I, Abe M, Izumi Y.
Autosomal Recessive Spinocerebellar Ataxia Type 9 With a Response to Phosphate
Repletion: A Case Report. Neurol Genet. 2023 May 9;9(3):e200070. doi:
10.1212/NXG.0000000000200070. PMID: 37529414; PMCID: PMC10389171.

9: Haji S, Fujita K, Oki R, Osaki Y, Miyamoto R, Morino H, Nagano S, Atsuta N,
Kanazawa Y, Matsumoto Y, Arisawa A, Kawai H, Sato Y, Sakaguchi S, Yagi K,
Hamatani T, Kagimura T, Yanagawa H, Mochizuki H, Doyu M, Sobue G, Harada M,
Izumi Y. An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-
ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study.
JMIR Res Protoc. 2023 Jan 30;12:e42032. doi: 10.2196/42032. PMID: 36716091;
PMCID: PMC9926342.

10: Sako W, Haji S, Abe T, Osaki Y, Matsumoto Y, Harada M, Izumi Y. M1/precuneus
ratio as a surrogate marker of upper motor neuron sign in ALS. J Neurol Sci.
2023 Feb 15;445:120548. doi: 10.1016/j.jns.2023.120548. Epub 2023 Jan 7. PMID:
36640663.

11: Fukushima K, Takamatsu N, Yamamoto Y, Yamazaki H, Yoshida T, Osaki Y, Haji
S, Fujita K, Sugie K, Izumi Y. Early diagnosis of amyotrophic lateral sclerosis
based on fasciculations in muscle ultrasonography: A machine learning approach.
Clin Neurophysiol. 2022 Aug;140:136-144. doi: 10.1016/j.clinph.2022.06.005. Epub
2022 Jun 17. PMID: 35772191.

12: Oki R, Izumi Y, Fujita K, Miyamoto R, Nodera H, Sato Y, Sakaguchi S,
Nokihara H, Kanai K, Tsunemi T, Hattori N, Hatanaka Y, Sonoo M, Atsuta N, Sobue
G, Shimizu T, Shibuya K, Ikeda K, Kano O, Nishinaka K, Kojima Y, Oda M, Komai K,
Kikuchi H, Kohara N, Urushitani M, Nakayama Y, Ito H, Nagai M, Nishiyama K,
Kuzume D, Shimohama S, Shimohata T, Abe K, Ishihara T, Onodera O, Isose S, Araki
N, Morita M, Noda K, Toda T, Maruyama H, Furuya H, Teramukai S, Kagimura T, Noma
K, Yanagawa H, Kuwabara S, Kaji R; Japan Early-Stage Trial of Ultrahigh-Dose
Methylcobalamin for ALS (JETALS) Collaborators. Efficacy and Safety of
Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A
Randomized Clinical Trial. JAMA Neurol. 2022 Jun 1;79(6):575-583. doi:
10.1001/jamaneurol.2022.0901. PMID: 35532908; PMCID: PMC9086935.

13: Haji S, Sako W, Murakami N, Osaki Y, Izumi Y. Serum NfL and CHI3L1 for ALS
and parkinsonian disorders in the process of diagnosis. J Neural Transm
(Vienna). 2022 Mar;129(3):301-309. doi: 10.1007/s00702-022-02470-z. Epub 2022
Feb 18. PMID: 35178615.

14: Sako W, Abe T, Matsumoto Y, Nakamura K, Haji S, Osaki Y, Harada M, Izumi Y.
The Cerebellum Is a Common Key for Visuospatial Execution and Attention in
Parkinson's Disease. Diagnostics (Basel). 2021 Jun 6;11(6):1042. doi:
10.3390/diagnostics11061042. PMID: 34204073; PMCID: PMC8229154.

15: Haji S, Sako W, Murakami N, Osaki Y, Furukawa T, Izumi Y, Kaji R. The value
of serum uric acid as a prognostic biomarker in amyotrophic lateral sclerosis:
Evidence from a meta-analysis. Clin Neurol Neurosurg. 2021 Apr;203:106566. doi:
10.1016/j.clineuro.2021.106566. Epub 2021 Feb 19. PMID: 33706058.

16: Sako W, Izumi Y, Abe T, Haji S, Murakami N, Osaki Y, Matsumoto Y, Harada M,
Kaji R. MR spectroscopy and imaging-derived measurements in the supplementary
motor area for biomarkers of amyotrophic lateral sclerosis. Neurol Sci. 2021
Oct;42(10):4257-4263. doi: 10.1007/s10072-021-05107-3. Epub 2021 Feb 17. PMID:
33594539.

17: Naito N, Kawano H, Yamashita Y, Kondo M, Haji S, Miyamoto R, Toyoda Y,
Kanematsu Y, Izumi Y, Bando Y, Nishioka Y. Neuropsychiatric systemic lupus
erythematosus with cerebellar vasculitis and obstructive hydrocephalus requiring
decompressive craniectomy. Mod Rheumatol Case Rep. 2021 Jan;5(1):52-57. doi:
10.1080/24725625.2020.1826626. Epub 2020 Oct 9. PMID: 33021438.

18: Murakami N, Sako W, Haji S, Furukawa T, Otomi Y, Otsuka H, Izumi Y, Harada
M, Kaji R. Differences in cerebellar perfusion between Parkinson's disease and
multiple system atrophy. J Neurol Sci. 2020 Feb 15;409:116627. doi:
10.1016/j.jns.2019.116627. Epub 2019 Dec 16. PMID: 31865188.

19: Sako W, Abe T, Haji S, Murakami N, Osaki Y, Izumi Y, Harada M, Kaji R. "One
line": A method for differential diagnosis of parkinsonian syndromes. Acta
Neurol Scand. 2019 Sep;140(3):229-235. doi: 10.1111/ane.13136. Epub 2019 Jun 21.
PMID: 31225648.

20: Murakami N, Sako W, Haji S, Furukawa T, Otomi Y, Otsuka H, Izumi Y, Harada
M, Kaji R. Potential Utility of <sup>123</sup>I-MIBG Scintigraphy as a Predictor
of Falls in Parkinson's Disease. Front Neurol. 2019 Apr 12;10:376. doi:
10.3389/fneur.2019.00376. PMID: 31031701; PMCID: PMC6473994.

21: Sako W, Abe T, Furukawa T, Oki R, Haji S, Murakami N, Izumi Y, Harada M,
Kaji R. Differences in the intra-cerebellar connections and graph theoretical
measures between Parkinson's disease and multiple system atrophy. J Neurol Sci.
2019 May 15;400:129-134. doi: 10.1016/j.jns.2019.03.022. Epub 2019 Mar 25. PMID:
30928779.

22: Haji S, Eto F, Torii T. Multijoint Pain and Pulmonary Calcification with
Long-term Hemodialysis. Intern Med. 2018 Oct 15;57(20):3063-3064. doi:
10.2169/internalmedicine.0443-17. Epub 2018 May 18. PMID: 29780115; PMCID:
PMC6232024.

23: Muto K, Matsui N, Unai Y, Sakai W, Haji S, Udaka K, Miki H, Furukawa T, Abe
M, Kaji R. Memory B cell resurgence requires repeated rituximab in myasthenia
gravis. Neuromuscul Disord. 2017 Oct;27(10):918-922. doi:
10.1016/j.nmd.2017.06.012. Epub 2017 Jun 21. PMID: 28694074.

24: Yoshida T, Mizuta I, Saito K, Kimura Y, Park K, Ito Y, Haji S, Nakagawa M,
Mizuno T. Characteristic abnormal signals in medulla oblongata-"eye spot" sign:
Four cases of elderly-onset Alexander disease. Neurol Clin Pract. 2015
Jun;5(3):259-262. doi: 10.1212/CPJ.0000000000000124. PMID: 29443213; PMCID:
PMC5764465.

25: Haji S, Kimura H, Yamashita H. Arthritis and bacteremia due to Leclercia
adecarboxylata. Intern Med. 2014;53(22):2659. doi:
10.2169/internalmedicine.53.2990. Epub 2014 Nov 15. PMID: 25400198.

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