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研究業績詳細
土屋 光（ツチヤ ヒカル）
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| 研究業績（論文） | 原著論文 1. Endo A*, Fukushima T, Takahashi C, Tsuchiya H, Ono S, Ly T, Yoshida Y, Tanaka K, Saeki Y*, Komada M*. USP8 prevents aberrant NF-kB and Nrf2 activation by counteracting ubiquitin signals from endosomes. J. Cell Biol., 223, 2024 2. Tsunoda, T., Riku, N. Yamada, N., Tsuchiya, H., Tomita, T., Suzuki, M., Kizuki, M., Inoko, A., Ito, H., Murotani, K., Murakami, H., Saeki, Y., and Kasai, K. ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. EMBO Rep. e51182 , 2021 3. *Yasuda S, * Tsuchiya, H. (* co-1st author), *Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y. Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature 578, 296-300, 2020 4. *Sato Y, *Tsuchiya, H. (* co-1st author), Yamagata A, Okatsu K, Tanaka, K, Saeki Y, Fukai S. Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4. Nat. Commun. 10, 5709 （2019） 5. Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka, K., and Saeki, Y. Ub-ProT reveals global length and composition of protein ubiquitylation in cells. Nat. Commun. 9, 524, 2018 6. Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K. K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains. Proc. Natl. Acad. Sci. USA. 115, E1401-E1408, 2018 7. Tsuchiya, H., Ohtake, F., Arai, N., Yasuda, S., Tanaka, K., and Saeki, Y. In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome. Mol. Cell 66, 488-502, 2017. 8. Yoshida, Y., Yasushi Saeki, Y., Murakami, A., Kawawaki, J., Tsuchiya, H., Yoshihara, H., Shindo, M., and Tanaka, K. (2015) A comprehensive method for detecting ubiquitinated substrates using TR-TUBE. Proc. Natl. Acad. Sci. USA 112, 4630 - 4635. 9. Morimoto, D., Walinda, E., Fukada, H., Sou, Y., Kageyama, S., Masaru Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., and Shirakawa, M., The unexpected role of polyubiquitin chains in the formation of fibrillar aggregate”, Nat Commun. 6, 6116, 2015 10. Ohtake, F., Saeki, Y., Sakamoto, K., Ohtake, K., Nishikawa, H., Tsuchiya, H., Ohta, T., Tanaka, K. Ubiquitin acetylation inhibits polyubiquitin chain elongation”, EMBO Rep. 19 doi:embr.201439152, 2014. 11. Koyano, F., Okatsu, K., Kosako, H., Tamura, Y. Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Edward A. Fon, Jean-François Trempe, Saeki, Y., Tanaka, K., and Matsuda, N., Ubiquitin is phosphorylated by PINK1 to activate parkin”, Nature 510, 162-166, 2014 12. Pack, C., Yukui, H., Toh-e, A., Kudo, T., Tsuchiya, H., Kaiho, A., Sakata, E., Murata, S., Yokosawa, H., Sako, Y., Baumeister, W., Tanaka, K., and Saeki, Y. Quantitative live-cell imaging reveals spatiotemporal dynamics and cytoplasmic assembly of the 26S proteasome”, Nat Commun. 2014, 13. Tsuchiya, H., Tanaka, K., and Saeki, Y. The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification. Biochem. Biophys. Res. Commun. 436, 223-229, 2013. |
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