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研究業績詳細
野村 園子（ノムラ ソノコ）
| 研究テーマ | 喘息モデルマウスにおける気道リモデリングへのTWEAKとCD163の役割 |
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| 研究業績（論文） | ① Yoko Katsura, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Fumihiko Makino, Jun Ito, Fumitaka Kamachi, Ko Okumura, Hisaya Akiba, Ryo Atsuta, Kazuhisa Takahashi. Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation. Exp Lung Res. 2015; 41: 370-382 ② Yukinari Itoigawa, Norihiro Harada, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Fariz Nurwidya, Motoyasu Kato, Fumiyuki Takahashi, Ryo Atsuta, Kazuhisa Takahashi. TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells. Respir Res. 2015; 16: 48 ③ Sonoko Harada,Norihiro Harada, Yukinari Itoigawa, Yoko Katsura, Fumiko Kasuga, Ayako Ishimori, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi. Evaluation of switching low-dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma. J Asthma. 2016; 53(2): 207-12. ④ Ayako Ishimori, Norihiro Harada, Asako Chiba, Sonoko Harada, Kei Matsuno, Fumihiko Makino, Jun Ito, Shoichiro Ohta, Junya Ono, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi, Sachiko Miyake. Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma. Allergol Int. 2017; 66: 302-309 ⑤ Kei Matsuno, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Ayako Ishimori, Yukinari Itoigawa, Yoko Katsura, Yuzo Kodama, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi. Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Exp Lung Res. 2018; 44(7): 332-343. ⑥ Mina Yasuda, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi. Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E. Allergy Asthma Clin Immunol. 2018; 14: 72. ⑦ Natsuko Maruyama, Toshiro Takai, Seiji Kamijo, Punyada Suchiva, Mai Ohba, Tomohito Takeshige, Mayu Suzuki, Mutsuko Hara, Kei Matsuno, Sonoko Harada, Norihiro Harada, Susumu Nakae, Katsuko Sudo, Toshiaki Okuno, Takehiko Yokomizo, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019;74(11):2237-2240. ⑧ Norihiro Harada, Sonoko Harada, Jun Ito, Ryo Atsuta, Satoshi Hori, Kazuhisa Takahashi. Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study. J Med Internet Res. 2020;22(8):e19006 ⑨ Sumiko Abe, Jun Ito, Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Tomohito Takeshige, Yoko Katsura, Norihiro Harada, Kazuhisa Takahashi. A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction, Allergy Asthma Clin Immunol. 2021;17(1):36. ⑩ Tanaka H, et al. (他451名、18番目), Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19, Int J Infect Dis.2021;113:74-81. ⑪ Tomohito Takeshige, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Hitoshi Sasano, Yuuki Sandhu, Kei Matsuno, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi. Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice. Allergol Int. 2021; 70: 343-350. ⑫ Shoko Ueda, Jun Ito, Norihiro Harada, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Sumiko Abe, Satomi Shiota, Yuzo Kodama, Tetsutaro Nagaoka, Fumihiko Makino, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Sachiko Miyake, Kazuhisa Takahashi. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules 2022; 12(4):518. ⑬ Namkoong, H, et al. (他486名、40番目), DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature 2022; 609(7928):754-760. ⑭ Wang, QBS, et al. (他442名、27番目), The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. Nat Commun. 2022; 13(1):4830. ⑮ Shiting Xu, Keita Miura, Takehito Shukuya, Sonoko Harada, Masahiro Fujioka, Wira Winardi, Shoko Shimamura, Kana Kurokawa, Issei Sumiyoshi, Taichi Miyawaki, Tetsuhiko Asao, Yoichiro Mitsuishi, Ken Tajima, Fumiyuki Takahashi, Takuo Hayashi, Norihiro Harada, Kazuhisa Takahashi. Early Detection of Therapeutic Benefit from PD-1/PD-L1 Blockade in Advanced Lung Cancer by Monitoring Cachexia-Related Circulating Cytokines. Cancers 2023; 15(4), 1170 ⑯ Yuuki Sandhu, Norihiro Harada, Hitoshi Sasano, Sonoko Harada, Shoko Ueda, Tomohito Takeshige, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Sumiko Abe, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, and Kazuhisa Takahashi. Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma. Biomolecules 2023; 13(3): 538. ⑰ Hitoshi Sasano, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Yuuki Sandhu, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, Kazuhisa Takahashi. Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int. 2024; 73(1): 94-106 |
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