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研究業績詳細

原田園子（ハラダソノコ）

研究テーマ	喘息モデルマウスにおける気道リモデリングへのTWEAKとCD163の役割
研究業績（論文）	1. Toshinobu Seki, Sonoko Harada, Osamu Hosoya, Kazuhiro Morimoto, Kazuhiko Juni. Evaluation of the establishment of a tight junction in Caco-2 cell monolayers using a pore permeation model involving two different sizes. Biol Pharm Bull. 2008 Jan;31(1):163-6. 2. Katsuyoshi Sunaga, Kenichi Ohkawa, Kenichi Nakamura, Atsuko Ohkubo, Sonoko Harada, Tadashi Tsuda. Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract. Biol Pharm Bull. 2012;35(3):329-34. 3. Yoko Katsura, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Fumihiko Makino, Jun Ito, Fumitaka Kamachi, Ko Okumura, Hisaya Akiba, Ryo Atsuta, Kazuhisa Takahashi. Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation. Exp Lung Res. 2015; 41: 370-382 4. Yukinari Itoigawa, Norihiro Harada, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Fariz Nurwidya, Motoyasu Kato, Fumiyuki Takahashi, Ryo Atsuta, Kazuhisa Takahashi. TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells. Respir Res. 2015; 16: 48. 5. Sonoko Harada, Norihiro Harada, Yukinari Itoigawa, Yoko Katsura, Fumiko Kasuga, Ayako Ishimori, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi. Evaluation of switching low-dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma. J Asthma. 2016; 53(2): 207-12. 6. Ayako Ishimori, Norihiro Harada, Asako Chiba, Sonoko Harada, Kei Matsuno, Fumihiko Makino, Jun Ito, Shoichiro Ohta, Junya Ono, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi, Sachiko Miyake. Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma. Allergol Int. 2017; 66: 302-309 7. Kei Matsuno, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Ayako Ishimori, Yukinari Itoigawa, Yoko Katsura, Yuzo Kodama, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi. Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Exp Lung Res. 2018; 44(7): 332-343. 8. Mina Yasuda, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi. Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E. Allergy Asthma Clin Immunol. 2018; 14: 72. 9. Yuki Tanabe, Norihiro Harada, Jun Ito, Kei Matsuno, Tomohito Takeshige, Sonoko Harada, Mirano Takemasa, Masaki Kotajima, Ayako Ishimori, Yoko Katsura, Fumihiko Makino, Ryo Atsuta, Kazuhisa Takahashi. Difference between two exhaled nitric oxide analyzers, NIOX VERO® electrochemical hand-held analyzer and NOA280i® chemiluminescence stationary analyzer. J Asthma. 2019 Feb;56(2):167-172. 10. Natsuko Maruyama, Toshiro Takai, Seiji Kamijo, Punyada Suchiva, Mai Ohba, Tomohito Takeshige, Mayu Suzuki, Mutsuko Hara, Kei Matsuno, Sonoko Harada, Norihiro Harada, Susumu Nakae, Katsuko Sudo, Toshiaki Okuno, Takehiko Yokomizo, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019;74(11):2237-2240. 11. Norihiro Harada, Sonoko Harada, Jun Ito, Ryo Atsuta, Satoshi Hori, Kazuhisa Takahashi. Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study. J Med Internet Res. 2020;22(8):e19006 12. Sumiko Abe, Jun Ito, Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Tomohito Takeshige, Yoko Katsura, Norihiro Harada, Kazuhisa Takahashi. A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction, Allergy Asthma Clin Immunol. 2021;17(1):36. 13. Tanaka H, et al. (他451名、18番目), Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19, Int J Infect Dis.2021;113:74-81. 14. Tomohito Takeshige, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Hitoshi Sasano, Yuuki Sandhu, Kei Matsuno, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi. Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice. Allergol Int. 2021; 70: 343-350. 15. Shoko Ueda, Jun Ito, Norihiro Harada, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Sumiko Abe, Satomi Shiota, Yuzo Kodama, Tetsutaro Nagaoka, Fumihiko Makino, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Sachiko Miyake, Kazuhisa Takahashi. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules 2022; 12(4):518. 16. Namkoong, H, et al. (他486名、40番目), DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature 2022; 609(7928):754-760. 17. Wang, QS, et al. (他442名、27番目), The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. Nat Commun. 2022; 13(1):4830. 18. Ho Lee, et al. (他35名, 36番目 Japan COVID-19 Task Force; 456名, 43番目). Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force. BMC Infect Dis. 2022 Dec 12;22(1):935. 19. Shiting Xu, Keita Miura, Takehito Shukuya, Sonoko Harada, Masahiro Fujioka, Wira Winardi, Shoko Shimamura, Kana Kurokawa, Issei Sumiyoshi, Taichi Miyawaki, Tetsuhiko Asao, Yoichiro Mitsuishi, Ken Tajima, Fumiyuki Takahashi, Takuo Hayashi, Norihiro Harada, Kazuhisa Takahashi. Early Detection of Therapeutic Benefit from PD-1/PD-L1 Blockade in Advanced Lung Cancer by Monitoring Cachexia-Related Circulating Cytokines. Cancers 2023; 15(4), 1170 20. Yuuki Sandhu, Norihiro Harada, Hitoshi Sasano, Sonoko Harada, Shoko Ueda, Tomohito Takeshige, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Sumiko Abe, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, and Kazuhisa Takahashi. Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma. Biomolecules 2023; 13(3): 538. 21. Hitoshi Sasano, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Yuuki Sandhu, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, Kazuhisa Takahashi. Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int. 2024;73(1):94-106 22. Yuuki Sandhu, Norihiro Harada, Sonoko Harada, Takayasu Nishimaki, Hitoshi Sasano, Yuki Tanabe, Tomohito Takeshige, Kei Matsuno, Ayako Ishimori, Yoko Katsura, Jun Ito, Hisaya Akiba, Kazuhisa Takahashi. MAP3K19 Affects TWEAK-Induced Response in Cultured Bronchial Epithelial Cells and Regulates Allergic Airway Inflammation in an Asthma Murine Model. Curr Issues Mol Biol. 2023 Nov 8;45(11):8907-8924. 23. Yuta Matsubara, et al. (他25名, 26番目 Japan COVID-19 Task Force; 464名, 32番目). Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study. J Gastroenterol. 2024 Mar;59(3):195-208. 24. Sumiko Abe, Mina Yasuda, Kazunori Tobino, Sonoko Harada, Hitoshi Sasano, Yuki Tanabe, Yuuki Sandhu, Tomohito Takeshige, Kei Matsuno, Tetsuhiko Asao, Takuto Sueyasu, Saori Nishizawa, Kohei Yoshimine, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide, Haruhi Takagi, Jun Ito, Tetsutaro Nagaoka, Norihiro Harada, Kazuhisa Takahashi. Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma. J Asthma Allergy. 2024 Apr 6;17:325-337. 25. Yoshihiko Tomofuji, et al. (他35名, 23番目 Japan COVID-19 Task Force; 568名, 88番目). Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues. Cell Genom. 2024 Aug 14;4(8):100625. doi: 10.1016/j.xgen.2024.100625. Epub 2024 Jul 30. 26. Sonoko Harada, Norihiro Harada, Hitoshi Sasano, Yuki Tanabe, Masaki Kotajima, Yoshihiko Sato, Tomohito Takeshige, Yoko Katsura, Jun Ito, Ryo Atsuta, Hajime Kurosawa, Kazuhisa Takahashi. Differences between oscillometry measurements obtained by MostGraph-01 and MasterScreen-IOS in patients with asthma. PLoS One. 2024 Sep 6;19(9):e0309981. 27. Yoshihiko Sato, Hitoshi Sasano, Sumiko Abe, Yuuki Sandhu, Shoko Ueda, Sonoko Harada, Yuki Tanabe, Kyoko Shima, Tetsuya Kuwano, Yuya Uehara, Takayoshi Inoue, Ko Okumura, Kazuhisa Takahashi, Norihiro Harada. Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients. Curr Issues Mol Biol. 2024 Oct 15;46(10):11425-11437. 28. Sumiko Abe, Norihiro Harada, Yuuki Sandhu, Hitoshi Sasano, Yuki Tanabe, Shoko Ueda, Takayasu Nishimaki, Yoshihiko Sato, Tomohito Takeshige, Sonoko Harada, Hisaya Akiba, Kazuhisa Takahashi. Co-Stimulation with TWEAK and TGF-β1 Induces Steroid-Insensitive TSLP and CCL5 Production in BEAS-2B Human Bronchial Epithelial Cells. Int J Mol Sci. 2024 Oct 29;25(21):11625. 29. Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Sumiko Abe, Yuki Tanabe, Kyoko Shima, Tetsuya Kuwano, Yuya Uehara, Takayoshi Inoue, Ko Okumura, Kazuhisa Takahashi, Norihiro Harada. Skin Surface Lipid-RNA Profile Obtained from Patients with Severe Asthma After Benralizumab Treatment. J Asthma Allergy. 2024 Nov 6;17:1103-1113. 30. Ai Goto, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi, Norihiro Harada. Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period. J Asthma Allergy. 2024 Nov 14;17:1173-1186. 31. Noah Sasa, et al. (他132名, 93番目 Japan COVID-19 Task Force; 421名, 18番目). Blood DNA virome associates with autoimmune diseases and COVID-19. Nat Genet. 2025 Jan;57(1):65-79. 32. Sonoko Harada, Motoyasu Kato, Kazuyuki Nakagome, Hitoshi Sasano, Yuki Tanabe, Tomohito Takeshige, Yuuki Sandhu, Kei Matsuno, Shoko Ueda, Sumiko Abe, Takayasu Nishimaki, Shun Shinomiya, Jun Ito, Sachiko Miyake, Ko Okumura, Makoto Nagata, Kazuhisa Takahashi, Norihiro Harada. Evaluating the Diagnostic Value of Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and Peripheral Blood Across Various Diffuse Interstitial Lung Disease Subtypes. Biomolecules. 2025 Jan 14;15(1):122. 33. Takayasu Nishimaki, Hitoshi Sasano, Sonoko Harada, Tomohito Takeshige, Yuuki Sandhu, Yuki Tanabe, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Ryo Atsuta, Mayu Ohuchi, Shigehiro Yagishita, Akinobu Hamada, Kazuhisa Takahashi, Norihiro Harada, Elevated mepolizumab levels in patients with severe asthma responsive to 1 year's mepolizumab treatment. J Allergy Clin Immunol Glob. 2025 Jan 16; 4(2):100410.

研究テーマ

喘息モデルマウスにおける気道リモデリングへのTWEAKとCD163の役割

研究業績（論文）

1. Toshinobu Seki, Sonoko Harada, Osamu Hosoya, Kazuhiro Morimoto, Kazuhiko Juni. Evaluation of the establishment of a tight junction in Caco-2 cell monolayers using a pore permeation model involving two different sizes. Biol Pharm Bull. 2008 Jan;31(1):163-6.
2. Katsuyoshi Sunaga, Kenichi Ohkawa, Kenichi Nakamura, Atsuko Ohkubo, Sonoko Harada, Tadashi Tsuda. Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract. Biol Pharm Bull. 2012;35(3):329-34.
3. Yoko Katsura, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Fumihiko Makino, Jun Ito, Fumitaka Kamachi, Ko Okumura, Hisaya Akiba, Ryo Atsuta, Kazuhisa Takahashi. Characteristics of alveolar macrophages from murine models of OVA-induced allergic airway inflammation and LPS-induced acute airway inflammation. Exp Lung Res. 2015; 41: 370-382
4. Yukinari Itoigawa, Norihiro Harada, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Fariz Nurwidya, Motoyasu Kato, Fumiyuki Takahashi, Ryo Atsuta, Kazuhisa Takahashi. TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells. Respir Res. 2015; 16: 48.
5. Sonoko Harada, Norihiro Harada, Yukinari Itoigawa, Yoko Katsura, Fumiko Kasuga, Ayako Ishimori, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi. Evaluation of switching low-dose inhaled corticosteroid to pranlukast for step-down therapy in well-controlled patients with mild persistent asthma. J Asthma. 2016; 53(2): 207-12.
6. Ayako Ishimori, Norihiro Harada, Asako Chiba, Sonoko Harada, Kei Matsuno, Fumihiko Makino, Jun Ito, Shoichiro Ohta, Junya Ono, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi, Sachiko Miyake. Circulating activated innate lymphoid cells and mucosal-associated invariant T cells are associated with airflow limitation in patients with asthma. Allergol Int. 2017; 66: 302-309
7. Kei Matsuno, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Ayako Ishimori, Yukinari Itoigawa, Yoko Katsura, Yuzo Kodama, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi. Combination of TWEAK and TGF-β1 induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition. Exp Lung Res. 2018; 44(7): 332-343.
8. Mina Yasuda, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Yukinari Itoigawa, Kei Matsuno, Fumihiko Makino, Jun Ito, Junya Ono, Kazunori Tobino, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Kazuhisa Takahashi. Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E. Allergy Asthma Clin Immunol. 2018; 14: 72.
9. Yuki Tanabe, Norihiro Harada, Jun Ito, Kei Matsuno, Tomohito Takeshige, Sonoko Harada, Mirano Takemasa, Masaki Kotajima, Ayako Ishimori, Yoko Katsura, Fumihiko Makino, Ryo Atsuta, Kazuhisa Takahashi. Difference between two exhaled nitric oxide analyzers, NIOX VERO® electrochemical hand-held analyzer and NOA280i® chemiluminescence stationary analyzer. J Asthma. 2019 Feb;56(2):167-172.
10. Natsuko Maruyama, Toshiro Takai, Seiji Kamijo, Punyada Suchiva, Mai Ohba, Tomohito Takeshige, Mayu Suzuki, Mutsuko Hara, Kei Matsuno, Sonoko Harada, Norihiro Harada, Susumu Nakae, Katsuko Sudo, Toshiaki Okuno, Takehiko Yokomizo, Hideoki Ogawa, Ko Okumura, Shigaku Ikeda. Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. Allergy. 2019;74(11):2237-2240.
11. Norihiro Harada, Sonoko Harada, Jun Ito, Ryo Atsuta, Satoshi Hori, Kazuhisa Takahashi. Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study. J Med Internet Res. 2020;22(8):e19006
12. Sumiko Abe, Jun Ito, Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Tomohito Takeshige, Yoko Katsura, Norihiro Harada, Kazuhisa Takahashi. A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction, Allergy Asthma Clin Immunol. 2021;17(1):36.
13. Tanaka H, et al. (他451名、18番目), Clinical Characteristics of Patients with Coronavirus Disease (COVID-19): Preliminary Baseline Report of Japan COVID-19 Task Force, a Nationwide Consortium to Investigate Host Genetics of COVID-19, Int J Infect Dis.2021;113:74-81.
14. Tomohito Takeshige, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Hitoshi Sasano, Yuuki Sandhu, Kei Matsuno, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi. Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice. Allergol Int. 2021; 70: 343-350.
15. Shoko Ueda, Jun Ito, Norihiro Harada, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Sumiko Abe, Satomi Shiota, Yuzo Kodama, Tetsutaro Nagaoka, Fumihiko Makino, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Sachiko Miyake, Kazuhisa Takahashi. Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen. Biomolecules 2022; 12(4):518.
16. Namkoong, H, et al. (他486名、40番目), DOCK2 is involved in the host genetics and biology of severe COVID-19. Nature 2022; 609(7928):754-760.
17. Wang, QS, et al. (他442名、27番目), The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force. Nat Commun. 2022; 13(1):4830.
18. Ho Lee, et al. (他35名, 36番目 Japan COVID-19 Task Force; 456名, 43番目). Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force. BMC Infect Dis. 2022 Dec 12;22(1):935.
19. Shiting Xu, Keita Miura, Takehito Shukuya, Sonoko Harada, Masahiro Fujioka, Wira Winardi, Shoko Shimamura, Kana Kurokawa, Issei Sumiyoshi, Taichi Miyawaki, Tetsuhiko Asao, Yoichiro Mitsuishi, Ken Tajima, Fumiyuki Takahashi, Takuo Hayashi, Norihiro Harada, Kazuhisa Takahashi. Early Detection of Therapeutic Benefit from PD-1/PD-L1 Blockade in Advanced Lung Cancer by Monitoring Cachexia-Related Circulating Cytokines. Cancers 2023; 15(4), 1170
20. Yuuki Sandhu, Norihiro Harada, Hitoshi Sasano, Sonoko Harada, Shoko Ueda, Tomohito Takeshige, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Sumiko Abe, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, and Kazuhisa Takahashi. Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma. Biomolecules 2023; 13(3): 538.
21. Hitoshi Sasano, Norihiro Harada, Sonoko Harada, Tomohito Takeshige, Yuuki Sandhu, Yuki Tanabe, Ayako Ishimori, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Asako Chiba, Hisaya Akiba, Ryo Atsuta, Kenji Izuhara, Sachiko Miyake, Kazuhisa Takahashi. Pretreatment circulating MAIT cells, neutrophils, and periostin predicted the real-world response after 1-year mepolizumab treatment in asthmatics. Allergol Int. 2024;73(1):94-106
22. Yuuki Sandhu, Norihiro Harada, Sonoko Harada, Takayasu Nishimaki, Hitoshi Sasano, Yuki Tanabe, Tomohito Takeshige, Kei Matsuno, Ayako Ishimori, Yoko Katsura, Jun Ito, Hisaya Akiba, Kazuhisa Takahashi. MAP3K19 Affects TWEAK-Induced Response in Cultured Bronchial Epithelial Cells and Regulates Allergic Airway Inflammation in an Asthma Murine Model. Curr Issues Mol Biol. 2023 Nov 8;45(11):8907-8924.
23. Yuta Matsubara, et al. (他25名, 26番目 Japan COVID-19 Task Force; 464名, 32番目). Gastrointestinal symptoms in COVID-19 and disease severity: a Japanese registry-based retrospective cohort study. J Gastroenterol. 2024 Mar;59(3):195-208.
24. Sumiko Abe, Mina Yasuda, Kazunori Tobino, Sonoko Harada, Hitoshi Sasano, Yuki Tanabe, Yuuki Sandhu, Tomohito Takeshige, Kei Matsuno, Tetsuhiko Asao, Takuto Sueyasu, Saori Nishizawa, Kohei Yoshimine, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide, Haruhi Takagi, Jun Ito, Tetsutaro Nagaoka, Norihiro Harada, Kazuhisa Takahashi. Usefulness of Computed Tomography for Evaluating the Effects of Bronchial Thermoplasty in Japanese Patients with Severe Asthma.
J Asthma Allergy. 2024 Apr 6;17:325-337.
25. Yoshihiko Tomofuji, et al. (他35名, 23番目 Japan COVID-19 Task Force; 568名, 88番目). Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues. Cell Genom. 2024 Aug 14;4(8):100625. doi: 10.1016/j.xgen.2024.100625. Epub 2024 Jul 30.
26. Sonoko Harada, Norihiro Harada, Hitoshi Sasano, Yuki Tanabe, Masaki Kotajima, Yoshihiko Sato, Tomohito Takeshige, Yoko Katsura, Jun Ito, Ryo Atsuta, Hajime Kurosawa, Kazuhisa Takahashi. Differences between oscillometry measurements obtained by MostGraph-01 and MasterScreen-IOS in patients with asthma. PLoS One. 2024 Sep 6;19(9):e0309981.
27. Yoshihiko Sato, Hitoshi Sasano, Sumiko Abe, Yuuki Sandhu, Shoko Ueda, Sonoko Harada, Yuki Tanabe, Kyoko Shima, Tetsuya Kuwano, Yuya Uehara, Takayoshi Inoue, Ko Okumura, Kazuhisa Takahashi, Norihiro Harada. Impact of Dupilumab on Skin Surface Lipid-RNA Profile in Severe Asthmatic Patients. Curr Issues Mol Biol. 2024 Oct 15;46(10):11425-11437.
28. Sumiko Abe, Norihiro Harada, Yuuki Sandhu, Hitoshi Sasano, Yuki Tanabe, Shoko Ueda, Takayasu Nishimaki, Yoshihiko Sato, Tomohito Takeshige, Sonoko Harada, Hisaya Akiba, Kazuhisa Takahashi. Co-Stimulation with TWEAK and TGF-β1 Induces Steroid-Insensitive TSLP and CCL5 Production in BEAS-2B Human Bronchial Epithelial Cells. Int J Mol Sci. 2024 Oct 29;25(21):11625.
29. Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Sumiko Abe, Yuki Tanabe, Kyoko Shima, Tetsuya Kuwano, Yuya Uehara, Takayoshi Inoue, Ko Okumura, Kazuhisa Takahashi, Norihiro Harada. Skin Surface Lipid-RNA Profile Obtained from Patients with Severe Asthma After Benralizumab Treatment. J Asthma Allergy. 2024 Nov 6;17:1103-1113.
30. Ai Goto, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi, Norihiro Harada. Japanese Patients with Severe Asthma Identified as Responders to Omalizumab Treatment at 2 Years Based on the GETE Score Continued Treatment for an Extended Period. J Asthma Allergy. 2024 Nov 14;17:1173-1186.
31. Noah Sasa, et al. (他132名, 93番目 Japan COVID-19 Task Force; 421名, 18番目). Blood DNA virome associates with autoimmune diseases and COVID-19. Nat Genet. 2025 Jan;57(1):65-79.
32. Sonoko Harada, Motoyasu Kato, Kazuyuki Nakagome, Hitoshi Sasano, Yuki Tanabe, Tomohito Takeshige, Yuuki Sandhu, Kei Matsuno, Shoko Ueda, Sumiko Abe, Takayasu Nishimaki, Shun Shinomiya, Jun Ito, Sachiko Miyake, Ko Okumura, Makoto Nagata, Kazuhisa Takahashi, Norihiro Harada. Evaluating the Diagnostic Value of Lymphocyte Subsets in Bronchoalveolar Lavage Fluid and Peripheral Blood Across Various Diffuse Interstitial Lung Disease Subtypes. Biomolecules. 2025 Jan 14;15(1):122.
33. Takayasu Nishimaki, Hitoshi Sasano, Sonoko Harada, Tomohito Takeshige, Yuuki Sandhu, Yuki Tanabe, Kei Matsuno, Tetsutaro Nagaoka, Jun Ito, Ryo Atsuta, Mayu Ohuchi, Shigehiro Yagishita, Akinobu Hamada, Kazuhisa Takahashi, Norihiro Harada, Elevated mepolizumab levels in patients with severe asthma responsive to 1 year's mepolizumab treatment. J Allergy Clin Immunol Glob. 2025 Jan 16; 4(2):100410.

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研究業績詳細

原田 園子（ハラダ ソノコ）

原田園子（ハラダソノコ）