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彭戈（ペング）

研究テーマ	抗菌ペプチドの免疫担当細胞や炎症性細胞に及ぼす影響
研究業績（論文）	1.Trujillo-Paez JV, Peng G, Le Thanh Nguyen H, Nakamura M, Umehara Y, Yue H, Ikutama R, Takahashi M, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. J Dermatol Sci. 2024. S0923-1811(24)00015-X. (Published as co-first author) 2.Umehara Y, Trujillo-Paez JV, Yue H, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. Calcitriol, an active form of vitamin D3, mitigates skin barrier dysfunction in atopic dermatitis NC/Nga mice. Int J Mol Sci. 2023; 24(11):9347. 3.Ikutama R, Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X₇, mechanistic target of rapamycin, and MAPK pathways. J Invest Dermatol. 2023; 143(5):751-761. (Published as co-first author) 4.Nguyen HLT, Peng G, Trujillo-Paez JV, Yue H, Ikutama R, Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide AMP-IBP5 suppresses dermatitis-like lesions in a mouse model of atopic dermatitis through the low-density lipoprotein receptor-related protein-1 receptor. Int J Mol Sci. 2023;24(6):5200. 5.Peng G, Tsukamoto S, Ikutama R, Nguyen HLT, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 2022;132(17): e156501. 6.Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and clinical evidence suggests that treatment with betacellulin can alleviate Th2-type cytokine-mediated impairment of skin barrier function. Int J Mol Sci. 2022;23(19):11520. 7.Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol. 2022. 36(12): e1030-e1033. 8.Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. A pancancer analysis of the oncogenic role of S100 calcium binding protein A7 (S100A7) in human tumors. Biology. 2022,11(2):284. 9.Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol. 2022, 87(3):714-715. 10.Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Candidalysin, a Virulence factor of candida albicans, stimulates mast cells by mediating cross-talk between signaling pathways activated by the dectin-1 receptor and MAPKs. J Clin Immunol. 2022, 42(5):1009-1025 11.Umehara Y, Takahashi M, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. The Antimicrobial peptides human β-Defensins induce the secretion of angiogenin in human dermal fibroblasts. Int J Mol Sci. 2022, 23(15):8800. 12.Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen. 2022, 30(2):232-244. 13.Kiatsurayanon C, Peng G, Niyonsaba F. Opposing roles of antimicrobial peptides in skin cancers. Curr Pharm Des. 2022, 28(3):248-258. 14.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration, and proliferation through the FGFR/JAK2/STAT3 signaling pathway. Front Immunol. 2021, 12:712781. 15.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: causes and treatments. Biomedicines. 2021, 9(3):229. 16.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez JV, Peng G, Yue H, Nguyen LTH, Niyonsaba F. Keratinocytes: innate immune cells in atopic dermatitis. Clin Exp Immunol. 2021, 204(3):296-309. 17.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy. 2021, 51(3):382-392. 18.Peng G, Niyonsaba F. Emerging therapies for atopic dermatitis. In Andreas Maur. Atopic dermatitis: from diagnosis to treatment (Chapter 4). New York, USA: Nova Science Publishers. 2020. 19.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapatham P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Implication of antimicrobial peptides in atopic dermatitis: role in regulation of skin barrier. Recent Research Advances in Biology. 2021. 20.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapatham P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Role of antimicrobial peptides in skin barrier repair in atopic dermatitis. Int J Mol Sci. 2020, 21, 7607. 21.Cheng R, Zhang H, Zong W, Tang J, Han X, Zhang L, Zhang X, Gu H, Shu Y, Peng G, Huang L, Liu Q, Gao X, Guo Y, Yao Z. Development and validation of new diagnostic criteria for atopic dermatitis in children of China. J Eur Acad Dermatol Venereol. 2020, 34, 542–548. 22.Wu W, Peng G, Yang F, Zhang Y, Mu Z, Han X. Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO-1 axis. Mol Med Rep. 2019, 20, 1761–1771. 23.Peng G, Mu Z, Cui L, Liu P, Wang Y, Wu W, Han X. Anti-IL-33 antibody has a therapeutic effect in an atopic dermatitis murine model induced by 2, 4-dinitrochlorobenzene. Inflammation. 2018, 41, 154–163. 24.Wang Y, Zhang Y, Peng G, Han X. Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1. Int Immunopharmacol. 2018, 60, 9–17. 25.Zhang Y, Peng G, Wang Y, Cui L, Wu W, Wang L, Liu C, Han X. Silencing of astrocyte elevated gene-1 inhibits proliferation and migration of melanoma cells and induces apoptosis. Clin Exp Pharmacol Physiol. 2017, 44, 815–826.

研究テーマ

抗菌ペプチドの免疫担当細胞や炎症性細胞に及ぼす影響

研究業績（論文）

1.Trujillo-Paez JV, *Peng G, Le Thanh Nguyen H, Nakamura M, Umehara Y, Yue H, Ikutama R, Takahashi M, Ikeda S, Ogawa H, Okumura K, Niyonsaba F. Calcitriol modulates epidermal tight junction barrier function in human keratinocytes. J Dermatol Sci. 2024. S0923-1811(24)00015-X. (*Published as co-first author)
2.Umehara Y, Trujillo-Paez JV, Yue H, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. Calcitriol, an active form of vitamin D3, mitigates skin barrier dysfunction in atopic dermatitis NC/Nga mice. Int J Mol Sci. 2023; 24(11):9347.
3.Ikutama R, *Peng G, Tsukamoto S, Umehara Y, Trujillo-Paez JV, Yue H, Nguyen HLT, Takahashi M, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X₇, mechanistic target of rapamycin, and MAPK pathways. J Invest Dermatol. 2023; 143(5):751-761. (*Published as co-first author)
4.Nguyen HLT, Peng G, Trujillo-Paez JV, Yue H, Ikutama R, Takahashi M, Umehara Y, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide AMP-IBP5 suppresses dermatitis-like lesions in a mouse model of atopic dermatitis through the low-density lipoprotein receptor-related protein-1 receptor. Int J Mol Sci. 2023;24(6):5200.
5.Peng G, Tsukamoto S, Ikutama R, Nguyen HLT, Umehara Y, Trujillo-Paez JV, Yue H, Takahashi M, Ogawa T, Kishi R, Tominaga M, Takamori K, Kitaura J, Kageyama S, Komatsu M, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway. J Clin Invest. 2022;132(17): e156501.
6.Peng G, Tsukamoto S, Umehara Y, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Experimental and clinical evidence suggests that treatment with betacellulin can alleviate Th2-type cytokine-mediated impairment of skin barrier function. Int J Mol Sci. 2022;23(19):11520.
7.Peng G, Tsukamoto S, Kishi R, Tominaga M, Takamori K, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Betacellulin is downregulated in plaque psoriasis and may reflect disease severity. J Eur Acad Dermatol Venereol. 2022. 36(12): e1030-e1033.
8.Peng G, Tsukamoto S, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. A pancancer analysis of the oncogenic role of S100 calcium binding protein A7 (S100A7) in human tumors. Biology. 2022,11(2):284.
9.Peng G, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Psoriatic lesional expression of SARS-CoV-2 receptor ACE2 is reduced by blockade of IL-17 signaling but not by other biologic treatments. J Am Acad Dermatol. 2022, 87(3):714-715.
10.Song P, Peng G, Yue H, Ogawa T, Ikeda S, Okumura K, Ogawa H, Niyonsaba F. Candidalysin, a Virulence factor of candida albicans, stimulates mast cells by mediating cross-talk between signaling pathways activated by the dectin-1 receptor and MAPKs. J Clin Immunol. 2022, 42(5):1009-1025
11.Umehara Y, Takahashi M, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Okumura K, Ogawa H, Niyonsaba F. The Antimicrobial peptides human β-Defensins induce the secretion of angiogenin in human dermal fibroblasts. Int J Mol Sci. 2022, 23(15):8800.
12.Yue H, Song P, Sutthammikorn N, Umehara Y, Trujillo-Paez JV, Nguyen HLT, Takahashi M, Peng G, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 improves diabetic wound healing. Wound Repair Regen. 2022, 30(2):232-244.
13.Kiatsurayanon C, Peng G, Niyonsaba F. Opposing roles of antimicrobial peptides in skin cancers. Curr Pharm Des. 2022, 28(3):248-258.
14.Takahashi M, Umehara Y, Yue H, Trujillo-Paez JV, Peng G, Nguyen HLT, Ikutama R, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. The antimicrobial peptide human β-defensin-3 accelerates wound healing by promoting angiogenesis, cell migration, and proliferation through the FGFR/JAK2/STAT3 signaling pathway. Front Immunol. 2021, 12:712781.
15.Umehara Y, Kiatsurayanon C, Trujillo-Paez JV, Chieosilapatham P, Peng G, Yue H, Nguyen HLT, Song P, Okumura K, Ogawa H, Niyonsaba F. Intractable itch in atopic dermatitis: causes and treatments. Biomedicines. 2021, 9(3):229.
16.Chieosilapatham P, Kiatsurayanon C, Umehara Y, Trujillo-Paez JV, Peng G, Yue H, Nguyen LTH, Niyonsaba F. Keratinocytes: innate immune cells in atopic dermatitis. Clin Exp Immunol. 2021, 204(3):296-309.
17.Yue H, Umehara Y, Trujillo-Paez JV, Peng G, Nguyen HLT, Chieosilapatham P, Kiatsurayanon C, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Exogenous factors in the pathogenesis of atopic dermatitis: irritants and cutaneous infections. Clin Exp Allergy. 2021, 51(3):382-392.
18.Peng G, Niyonsaba F. Emerging therapies for atopic dermatitis. In Andreas Maur. Atopic dermatitis: from diagnosis to treatment (Chapter 4). New York, USA: Nova Science Publishers. 2020.
19.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapatham P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Implication of antimicrobial peptides in atopic dermatitis: role in regulation of skin barrier. Recent Research Advances in Biology. 2021.
20.Nguyen HLT, Trujillo-Paez JV, Umehara Y, Yue H, Peng G, Kiatsurayanon C, Chieosilapatham P, Song P, Okumura K, Ogawa H, Ikeda S, Niyonsaba F. Role of antimicrobial peptides in skin barrier repair in atopic dermatitis. Int J Mol Sci. 2020, 21, 7607.
21.Cheng R, Zhang H, Zong W, Tang J, Han X, Zhang L, Zhang X, Gu H, Shu Y, Peng G, Huang L, Liu Q, Gao X, Guo Y, Yao Z. Development and validation of new diagnostic criteria for atopic dermatitis in children of China. J Eur Acad Dermatol Venereol. 2020, 34, 542–548.
22.Wu W, Peng G, Yang F, Zhang Y, Mu Z, Han X. Sulforaphane has a therapeutic effect in an atopic dermatitis murine model and activates the Nrf2/HO-1 axis. Mol Med Rep. 2019, 20, 1761–1771.
23.Peng G, Mu Z, Cui L, Liu P, Wang Y, Wu W, Han X. Anti-IL-33 antibody has a therapeutic effect in an atopic dermatitis murine model induced by 2, 4-dinitrochlorobenzene. Inflammation. 2018, 41, 154–163.
24.Wang Y, Zhang Y, Peng G, Han X. Glycyrrhizin ameliorates atopic dermatitis-like symptoms through inhibition of HMGB1. Int Immunopharmacol. 2018, 60, 9–17.
25.Zhang Y, Peng G, Wang Y, Cui L, Wu W, Wang L, Liu C, Han X. Silencing of astrocyte elevated gene-1 inhibits proliferation and migration of melanoma cells and induces apoptosis. Clin Exp Pharmacol Physiol. 2017, 44, 815–826.

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研究業績詳細

彭 戈（ペン グ）

彭戈（ペング）