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北條浩彦（ホウジョウヒロヒコ）

研究テーマ	機能性RNAを基盤とした生命科学研究
研究業績（論文）	1. Zhang C., Raveney B., Takahashi F., Hohjoh H., Yeh T., Yamamura T., and Oki S. (2023) Pathogenic microglia orchestrate neurotoxic properties of Eomes-expressing helper T cells. Cells, 12: 868. 2. Shimizu H. and Hohjoh H. (2023) FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system. Sci Rep, 13(1): 1956. 3. Takahashi F., Zhang C., Hohjoh H., Raveney B., Yamamura T., Hayashi N., and Oki S. (2022) Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1. iScience, 25(5): 104278. 4. Jia H., Lyu W., Hirota K., Saito E., Miyoshi M., Hohjoh H., Furukawa K., Saito K., Haritani M., Tagushi A., Hasebe Y., and Kato H. (2022) Eggshell membrane modulates gut microbiota to prevent murine pre-cachexia through suppression of T helper cell differentiation. J Cachexia Sarcopenia Muscle, 13(4): 2088-2101. 5. Manu M.S., Hohjoh H., and Yamamura T. (2021) Extracellular Vesicles as Pro- and Anti-inflammatory Mediators, Biomarkers and Potential Therapeutic Agents in Multiple Sclerosis. Aging Dis, 12:1451-1461. 6. Fukuoka M., Fujita H., Numao K., Nakamura Y., Shimizu H., Sekiguchi M., and Hohjoh H. (2021) MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy. Communications Biol, 4: 427. 7. Gunarta I. K., Yuliana D., Erdenebaatar P., Kishi Y., Boldbaatar J., Suzuki R., Odongoo R., Davaakhuu G., Hohjoh H., and Yoshioka K. (2021) c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) attenuates curcumin-induced cell death differently from its family member, JNK-associated leucine zipper protein (JLP). Drug Discov Ther, 15: 66-72. 8. Miyoshi M., Imakado Y., Otani L., Kaji M., Aanzai Y., Sugimoto N., Murakami T., Fukuoka M., Hohjoh H., Jia H., and Kato H. (2021) Maternal protein restriction induces renal AT2R promoter hypomethylation in salt-sensitive, hypertensive rats. Food Sci Nutr, 9: 1452-1459. 9. Boldbaatar J., Gunarta IK., Suzuki R., Erdenebaatar P., Davaakhuu G., Hohjoh H., and Yoshioka K. (2020) Protective role of c-Jun NH2-terminal kinase-associated leucine zipper protein (JLP) in curcumin-induced cancer cell death. BBRC, 522: 697-703. 10. Zhang C., Raveney B., Hohjoh H., Tomi C., Oki S., and Yamamura T. (2019) Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating chronic neuroinflammation. Proc Natl Acad Sci USA, 116(42): 21131-21139. 11. Fukuoka M., Yoshioka K., and Hohjoh H. (2018) NF-kB activation is an early event of changes in gene regulation for acquiring drug resistance in human adenocarcinoma PC-9 cells. PLoS ONE, 13(8): e0201796. 12. Kimura K., Hohjoh H., and Yamamura T. (2018) The role for exosomal microRNAs in disruption of regulatory T cell homeostasis in multiple sclerosis. J Exp Neurosci, 12: 1179069518764892. 13. Fukuoka M., Takahashi M., Fujita H., Chiyo T., Popiel A., Watanabe S., Furuya H., Murata M., Wada K., Okada T., Nagai Y., and Hohjoh H. (2018) Supplemental treatment for Huntington’s disease with miR-132 that is deficient in Huntington’s disease brain. Mol Ther Nucleic Acids, 11: 79-90. 14. Kimura K., Hohjoh H., Fukuoka M., Sato W., Oki S., Tomi C., Yamaguchi H., Kondo T., Takahashi R., and Yamamura T. (2018) Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis. Nature Communications, 9: 17. 15. Fukuoka M., and Hohjoh H. (2018) Comprehensive measurement of gene silencing involving endogenous microRNAs in mammalian cells. In MicroRNA Protocols. Methods Mol Biol, 1733: 181-192. 16. Takahashi M., Fukuoka M., Yoshioka K., and Hohjoh H. (2016) Neighbors' death is required for surviving human adenocarcinoma PC-9 cells in an early stage of gefitinib treatment. BBRC, 479: 393-397. 17. Raveney B., Oki S., Hohjoh H., Nakamura M., Sato W., Murata M., and Yamamura T. (2015) Eomesodermin-expressing T helper cells are essential for chronic neuroinflammation. Nature Communications, 6: 8437. 18. Adachi N., Numakawa T., Nakajima S., Fukuoka M., Odaka H., Katanuma Y., Ooshima Y., Hohjoh H., and Kunugi H. (2015) Glucocorticoid affects dendritic transport of BDNF-containing vesicles. Sci Rep, 5: 12684. 19. Takahashi M., Suzuki M., Fukuoka M., Fujikake N., Watanabe S., Murata M., Wada K., Nagai Y., and Hohjoh H. (2015) Normalization of overexpressed alpha-synuclein causing Parkinson’s disease by a moderate gene silencing with RNA interference. Mol Ther Nucleic Acids, 4: e241. 20. Takahashi M. and Hohjoh H. (2014) A novel measurement of allele discrimination for assessment of allele-specific silencing by RNA interference. Mol Biol Rep, 41: 7115-7120. 21. Fukuoka M., Yoshida M., Eda A., Takahashi M.,　and Hohjoh H. (2014) Gene silencing mediated by endogenous microRNAs under heat stress conditions in mammalian cells. PLoS ONE, 9(7): e103130. 22. Araki W., Minegishi S., Motoki K., Kume H., Hohjoh H., Araki YM., and Tamaoka A. (2014) Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway. Mol Neurobiol, 50: 1049-1058. 23. Takahashi M., Chiyo T., Okada T., and Hohjoh H. (2013) Specific inhibition of tumor cells by oncogenic EGFR specific silencing by RNA interference. PLoS ONE, 8(8): e73214. 24. Hohjoh H. (2013) Disease-causing allele-specific silencing by RNA interference. Pharmaceuticals, 6: 522-535. 25. Kabuta T., Mitsui T., Takahashi M., Fujiwara Y., Kabuta C., Konya C., Tsuchiya Y., Hatanaka Y., Uchida K., Hohjoh H., and Wada K. (2013) Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as novel potentiator of cyclin-dependent kinases to enhance cell proliferation, independent of its hydrolase activity. J Biol Chem, 288: 12615-12626. 26. Hohjoh H. (2013) MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells. In MicroRNA Protocols. Methods Mol Biol, 936: 257-269. 27. Shin M., Ohte S., Fukuda T., Sasanuma H., Yoneyama K., Kokabu S., Miyamoto A., Tsukamoto S., Hohjoh H., Jimi E., and Katagiri T. (2013) Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes. J Bone Miner Metab, 31: 34-43. 28. Takahashi M., Eda A., Fukushima T., and Hohjoh H. (2012) Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klotho-deficient, senescence-model mouse. PLoS ONE, 7(11): e48974. 29. Hamasaki M., Hashizume Y., Yamada Y., Katayama T., Hohjoh H., Fusaki N., Nakashima Y., Furuya H., Haga N., Takami Y., and Era T. (2012) Pathogenic mutation of ALK2 inhibits iPS cell reprogramming and maintenance: mechanisms of reprogramming and strategy for drug identification. Stem Cells, 30: 2437-2449. 30. Takahashi M., Katagiri T., Furuya H., and Hohjoh H. (2012) Disease-causing allele specific silencing against the ALK2 mutants, R206H and G356D, in Fibrodysplasia Ossificans Progressiva. Gene Therapy, 19: 781-785. 31. Ohnishi Y., Totoki Y., Toyoda A., Watanabe T., Yamamoto Y., Tokunaga K., Sakaki Y., Sasaki H., and Hohjoh H. (2012) Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development. Mol Biol Rep, 39: 903-909. 32. Eda A., Takahashi M., Fukushima T., and Hohjoh H. (2011) Alteration of microRNA expression in the process of mouse brain growth. Gene, 485: 46-52. 33. Takahashi M., Watanabe S., Murata M., Furuya H., Kanazawa I., Wada K., and Hohjoh H. (2010) Tailor-made RNAi knockdown against triplet repeat disease-causing alleles. Proc Natl Acad Sci USA, 107: 21731-21736. 34. Ohnishi Y., Totoki Y., Toyoda A., Watanabe T., Yamamoto Y., Tokunaga K., Sakaki Y., Sasaki H., and Hohjoh H. (2010) Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucl Acids Res, 38: 5141-5151. 35. Hohjoh H. (2010) Allele-specific silencing by RNA interference. In RNA interference. Methods Mol Biol, 623: 67-79. 36. Eda A., Tamura Y., Yoshida M., and Hohjoh H. (2009) Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell. BBRC, 388: 648-653. 37. Kitamura K., Itou Y., Yanazawa M., Ohsawa M., Suzuki-Migishima R., Umeki Y., Hohjoh H., Yanagawa Y., Shinba T., Itoh M., Nakamura K., and Goto Y. (2009) Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum Mol Genet, 18: 3708-3724. 38. Hohjoh H., Akari H., Fujiwara Y., Tamura Y., Hirai H., and Wada K. (2009) Molecular cloning and characterization of the common marmoset huntingtin gene. Gene, 432: 60-66. 39. Tamura Y., Yoshida M., Ohnishi Y., and Hohjoh H. (2009) Variation of gene silencing involving endogenous microRNA in mammalian cells. Mol Biol Rep, 36: 1413-1420. 40. Doi Y., Oki S., Ozawa T., Hohjoh H., Miyake S., and Yamamura T. (2008) Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Natl Acad Sci USA, 105: 8381-8386. 41. Ohnishi Y., Tamura Y., Yoshida M., Tokunaga K., and Hohjoh H. (2008) Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi. PLoS ONE 3(5): e2248. 42. Hohjoh H. and Fukushima T. (2007) Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. BBRC, 362: 360-367. 43. Tamura Y., Kunugi H., Ohashi J. and Hohjoh H. (2007) The possible association between epigenetic aberration in DNA methylation in RELN and psychiatric disorders. Mol Psychiatry, 12: 519. 44. Tamura Y., Kunugi H., Ohashi J. and Hohjoh H. (2007) Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry, 12: 593-600. 45. Hohjoh H. and Fukushima T. (2007) Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing. Gene, 391: 39-44. 46. Ohashi J., Naka I., Toyoda A., Takasu M., Tokunaga K., Ishida T., Sakaki Y., and Hohjoh H. (2006) Estimation of the species-specific mutation rates of the DRB1 locus in human and chimpanzee. Tissue Antigens, 68: 427-431. 47. Sakai T. and Hohjoh H. (2006) Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference. Cell Biol Int, 30: 952-956. 48. Kawashima M., Tamiya G., Oka A., Hohjoh H., Juli T., Ebisawa T., Honda Y., Inoko H., and Tokunaga K. (2006) Genome-wide association analysis of human narcolepsy and a new resistance gene. Am J Hum Genet, 79: 252-263. 49. Ohnishi Y., Tokunaga K., Kaneko K., and Hohjoh H. (2006) Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles. J RNAi Gene silencing, 2: 154-160. 50. Kawashima M., Ikuta T., Tamiya G., Hohjoh H., Honda Y., Juji T., Tokunaga K., and Inoko H. (2006) Genome-wide association study of narcolepsy: initial screening on chromosome6. In: Dupont J, Hansen JA (eds) HLA 2004: immunobiology of the human MHC. Proceedings of the 13th International Histocompatibility Workshop and Conference. Volume 1 & II, IHWG Press, Seattle, WA, (ISBN 0-945278-03-9). 51. Ohnishi Y., Tokunaga K., and Hohjoh H. (2005) Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3’- or 5’-end of the sense-stranded siRNA element. BBRC, 329: 516-521. 52. Tamura Y., Sakasegawa Y., Omi K., Kishida H., Asada T., Kimura H., Tokunaga K., Hachiya N.S., Kaneko K., and Hohjoh H. (2005) Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer’s disease in a Japanese population. Neurosci Letters, 379: 149-151. 53. Sago N., Omi K., Tamura Y., Kunugi H., Toyo-ka T., Tokunaga K., and Hohjoh H. (2004) RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed. BBRC, 319: 50-57. 54. Omi K., Tokunaga K., and Hohjoh H. (2004) Long-lasting RNAi activity in mammalian neurons. FEBS letters, 558: 89-95. 55. Hohjoh H. (2004) Enhancement of RNAi activity by improved siRNA duplexes. FEBS letters, 557: 193-198. 56. Hohjoh H., Ohashi J., Takasu M., Nishioka T., Ishida T., and Tokunaga K. (2003) Recent divergence of the HLA-DRB104 allelic lineage from the DRB10701 lineage after the separation of the human and chimpanzee species. Immunogenetics, 54: 856-861. 57. Hohjoh H., Takashu M., Shishikura K., Takahashi Y., Honda Y., and Tokunaga K. (2003) Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics, 4: 151-153. 58. Hohjoh H. (2002) RNA interference (RNAi) induction with various types of synthetic oligonucleotide duplexes in cultured human cells. FEBS letters, 521: 195-199. 59. Kawashima M., Hohjoh H., Terada N., Komata T., Honda Y., and Tokunaga K. (2001) Association studies of the tumor necrosis factor-alpha (TNFA) and its receptor 1 (TNFR1) and 2 (TNFR2) genes with human narcolepsy. Korean J Genet, 23: 365-370. 60. Lapteva N., Ando Y., Nieda M., Hohjoh H., Okai M., Kikuchi A., Dymshits G., Ishikawa Y., Juji T., and Tokunaga K. (2001) Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array. Br J Haematol, 114:191-197. 61. Mignot E., Lin L., Rogers W., Honda Y., Qiu X., Lin X., Okun M., Hohjoh H., Miki T., Hsu S.H., Leffell M.S., Grumet F.C., Fernandex-Vina M., Honda M., and Risch N. (2001) Complex HLA-DR and –DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet, 68: 686-699. 62. Hohjoh H., Terada N., Nakayama T., Kawashima M., Miyagawa T., Honda Y., and Tokunaga K. (2001) Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB11501 and –DQB10602. Tissue Antigens, 57: 230-235. 63. Hohjoh H. and Tokunaga K. (2001) Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter. Genes and Immunity, 2: 105-109. 64. Hohjoh H., Terada N., Miki T., Honda Y., and Tokunaga K. (2001) Haplotype analyses with the human leukocyte antigen (HLA) and tumor necrosis factor-alpha (TNF-) genes in narcolepsy. Psychiatry Clin Neurosci, 55: 37-39. 65. Hohjoh H., Terada N., Honda Y., Juji T., and Tokunaga K. (2001) Negative association of the HLA-DRB11502-DQB10601 haplotype with human narcolepsy. Immunogenetics, 52: 299-301. 66. Chida S., Hohjoh H., Hirai M., and Tokunaga K. (2001) Haplotype specific sequence encoding protein kinase, interferon-inducible double stranded RNA dependent activator (PRKRA) in the human leukocyte antigen (HLA) class II region. Immunogenetics, 52: 186-194. 67. Takahashi Y., Hohjoh H., and Matsuura K. (2000) Predisposing factors in delayed sleep phase syndrome. Psychiatry Clin Neurosci, 54: 356-358. 68. Akaho R., Matsushita I., Narita K., Okazaki Y., Okabe Y., Matsushita M., Hohjoh H., Tokunaga K., and Sasaki T. (2000) Support for an association between HLA-DR1 and schizophrenia in the Japanese population. Am J Med Genet, 96: 725-727. 69. Miyagawa T., Hohjoh H., Honda Y., Juji T., and Tokunaga K. (2000) Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy. Immunogenetics, 52: 12-18. 70. Hohjoh H., Terada N., Kawashima M., Honda Y., and Tokunaga K. (2000) Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene　with human narcolepsy. Tissue Antigens, 56: 446-448. 71. Wu M.S., Tani K., Sugiyama H., Hibino H., Izawa K., Tanabe T., Nakazaki Y., Ishii H., Ohashi J., Hohjoh H., Iseki T., Tojo A., Nakamura Y. Tanioka Y., Tokunaga K., and Asano S. (2000) MHC (major histocompatibility complex)-DRB genes and polymorphisms in common marmoset. J Mol Evol, 51: 214-222. 72. Umino Y., Hohjoh H., and Tokunaga K. (2000) Novel single nucleotide polymorphisms (SNPs) at positions 497(T/G) and 829(T/C) in the human c-FOS gene and haplotype association. Hum Mutation, 16: 279. 73. Shihikura K., Hohjoh H., and Tokunaga K. (2000) Novel allele containing a 190(C→T) nonsynonymous substitution in the N-acetyltransferase (NAT2) gene. Hum Mutation, 15: 581. 74. Narita K., Sasaki T., Akaho R., Okazaki Y., Kusumi I., Kato T., Hashimoto O., Fukuda R., Koyama T., Matsuo K., Okabe Y., Nanko S. Hohjoh H. and Tokunaga K. (2000) HLA-DR1 and season of birth in Japanese patients with schizophrenia. Am J Psychiatry, 157: 1173-1175. 75. Chida S., Hohjoh H., and Tokunaga K. (1999) Molecular analyses of the possible RNA-binding protein gene located in the human leukocyte antigen (HLA)-DR subregion. Gene, 240: 125-132. 76. Hohjoh H., Nakayama T., Ohashi J., Miyagawa T., Tanaka H., Akaza T., Honda Y., Juji T., and Tokunaga K. (1999) Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-) gene promoter with human narcolepsy. Tissue Antigens, 54: 138-145. 77. Hohjoh H., Takahashi Y., Hatta Y., Tanaka H., Akaza T., Tokunaga K., Honda Y., and Juli T. (1999) Possible association of human leukocyte antigen DR1 with delayed sleep phase syndrome. Psychiatry Clin Neurosci, 53: 527-529. 78. Chida S., Wakui M., Hohjoh H., Ishikawa Y., Tsuchiya N., Juji T. and Tokunaga K. (1998) A possible new gene encoding and RNA binding protein in the class II region and a MICA-MICB null haplotype in the class I region. In the 10th International Congress of Immunology (Talwar G.P., and Ganguly N.K., eds), pp.39-42, Monduzzi Editore S.p.A, Bologna-Italy. 79. Hohjoh H. and Singer M.F. (1997) Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon. EMBO J, 16: 6034-6043. 80. Hohjoh H. and Singer M.F. (1997) Ribonuclease and high salt sensitivity of the ribonucleoprotein complex formed by the human LINE-1 retrotransposon. J Mol Biol, 271: 7-12. 81. *Hohjoh H. and Singer M.F. (1996) Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA. EMBO J, 15: 630-639. 82. Ito T., Hohjoh H., and Sakaki Y. (1993) Pulsed-field polyacrylamide gel electrophoresis: Basic phenomena and applications. Electrophoresis, 14: 278-282. 83. Moriyama K., Nakajima E., Hohjoh H., Asayama R., and Okochi K. (1991) Immunoselected hepatitis B virus mutant. Lancet, Jan 12: 125. 84. Hohjoh H., Minakami R., and Sakaki Y. (1990) Selective cloning and sequence analysis of the human L1 (LINE-1) sequence which transposed in the relatively recent past. Nucl Acids Res, 18: 4099-4104. 85. Sakaki Y. Hohjoh H., Minakami R., Ito T., Hattori M., Fujita A., and Saigo K. (1989) L1 retroposon-like sequence of human genome: structure and evolution. In Highlights of Modern Biochemistry (Kotyk A., Skoda J., Paces V., and Kostka V., eds), pp.559-568, VSP International Science Publishers, Zeist.

研究テーマ

機能性RNAを基盤とした生命科学研究

研究業績（論文）

1. Zhang C., Raveney B., Takahashi F., Hohjoh H., Yeh T., Yamamura T., and Oki S. (2023) Pathogenic microglia orchestrate neurotoxic properties of Eomes-expressing helper T cells. Cells, 12: 868.
2. Shimizu H. and Hohjoh H. (2023) FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system. Sci Rep, 13(1): 1956.
3. Takahashi F., Zhang C., Hohjoh H., Raveney B., Yamamura T., Hayashi N., and Oki S. (2022) Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1. iScience, 25(5): 104278.
4. Jia H., Lyu W., Hirota K., Saito E., Miyoshi M., Hohjoh H., Furukawa K., Saito K., Haritani M., Tagushi A., Hasebe Y., and Kato H. (2022) Eggshell membrane modulates gut microbiota to prevent murine pre-cachexia through suppression of T helper cell differentiation. J Cachexia Sarcopenia Muscle, 13(4): 2088-2101.
5. Manu M.S., Hohjoh H., and Yamamura T. (2021) Extracellular Vesicles as Pro- and Anti-inflammatory Mediators, Biomarkers and Potential Therapeutic Agents in Multiple Sclerosis. Aging Dis, 12:1451-1461.
6. Fukuoka M., Fujita H., Numao K., Nakamura Y., Shimizu H., Sekiguchi M., and *Hohjoh H. (2021) MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy. Communications Biol, 4: 427.
7. Gunarta I. K., Yuliana D., Erdenebaatar P., Kishi Y., Boldbaatar J., Suzuki R., Odongoo R., Davaakhuu G., Hohjoh H., and Yoshioka K. (2021) c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) attenuates curcumin-induced cell death differently from its family member, JNK-associated leucine zipper protein (JLP). Drug Discov Ther, 15: 66-72.
8. Miyoshi M., Imakado Y., Otani L., Kaji M., Aanzai Y., Sugimoto N., Murakami T., Fukuoka M., Hohjoh H., Jia H., and Kato H. (2021) Maternal protein restriction induces renal AT2R promoter hypomethylation in salt-sensitive, hypertensive rats. Food Sci Nutr, 9: 1452-1459.
9. Boldbaatar J., Gunarta IK., Suzuki R., Erdenebaatar P., Davaakhuu G., Hohjoh H., and Yoshioka K. (2020) Protective role of c-Jun NH2-terminal kinase-associated leucine zipper protein (JLP) in curcumin-induced cancer cell death. BBRC, 522: 697-703.
10. Zhang C., Raveney B., Hohjoh H., Tomi C., Oki S., and Yamamura T. (2019) Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating chronic neuroinflammation. Proc Natl Acad Sci USA, 116(42): 21131-21139.
11. Fukuoka M., Yoshioka K., and *Hohjoh H. (2018) NF-kB activation is an early event of changes in gene regulation for acquiring drug resistance in human adenocarcinoma PC-9 cells. PLoS ONE, 13(8): e0201796.
12. Kimura K., Hohjoh H., and Yamamura T. (2018) The role for exosomal microRNAs in disruption of regulatory T cell homeostasis in multiple sclerosis. J Exp Neurosci, 12: 1179069518764892.
13. Fukuoka M., Takahashi M., Fujita H., Chiyo T., Popiel A., Watanabe S., Furuya H., Murata M., Wada K., Okada T., Nagai Y., and *Hohjoh H. (2018) Supplemental treatment for Huntington’s disease with miR-132 that is deficient in Huntington’s disease brain. Mol Ther Nucleic Acids, 11: 79-90.
14. Kimura K., Hohjoh H., Fukuoka M., Sato W., Oki S., Tomi C., Yamaguchi H., Kondo T., Takahashi R., and Yamamura T. (2018) Circulating exosomes suppress the induction of regulatory T cells via let-7i in multiple sclerosis. Nature Communications, 9: 17.
15. Fukuoka M., and *Hohjoh H. (2018) Comprehensive measurement of gene silencing involving endogenous microRNAs in mammalian cells. In MicroRNA Protocols. Methods Mol Biol, 1733: 181-192.
16. Takahashi M., Fukuoka M., Yoshioka K., and *Hohjoh H. (2016) Neighbors' death is required for surviving human adenocarcinoma PC-9 cells in an early stage of gefitinib treatment. BBRC, 479: 393-397.
17. Raveney B., Oki S., Hohjoh H., Nakamura M., Sato W., Murata M., and Yamamura T. (2015) Eomesodermin-expressing T helper cells are essential for chronic neuroinflammation. Nature Communications, 6: 8437.
18. Adachi N., Numakawa T., Nakajima S., Fukuoka M., Odaka H., Katanuma Y., Ooshima Y., Hohjoh H., and Kunugi H. (2015) Glucocorticoid affects dendritic transport of BDNF-containing vesicles. Sci Rep, 5: 12684.
19. Takahashi M., Suzuki M., Fukuoka M., Fujikake N., Watanabe S., Murata M., Wada K., Nagai Y., and *Hohjoh H. (2015) Normalization of overexpressed alpha-synuclein causing Parkinson’s disease by a moderate gene silencing with RNA interference. Mol Ther Nucleic Acids, 4: e241.
20. Takahashi M. and *Hohjoh H. (2014) A novel measurement of allele discrimination for assessment of allele-specific silencing by RNA interference. Mol Biol Rep, 41: 7115-7120.
21. Fukuoka M., Yoshida M., Eda A., Takahashi M.,　and *Hohjoh H. (2014) Gene silencing mediated by endogenous microRNAs under heat stress conditions in mammalian cells. PLoS ONE, 9(7): e103130.
22. Araki W., Minegishi S., Motoki K., Kume H., Hohjoh H., Araki YM., and Tamaoka A. (2014) Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway. Mol Neurobiol, 50: 1049-1058.
23. Takahashi M., Chiyo T., Okada T., and *Hohjoh H. (2013) Specific inhibition of tumor cells by oncogenic EGFR specific silencing by RNA interference. PLoS ONE, 8(8): e73214.
24. *Hohjoh H. (2013) Disease-causing allele-specific silencing by RNA interference. Pharmaceuticals, 6: 522-535.
25. Kabuta T., Mitsui T., Takahashi M., Fujiwara Y., Kabuta C., Konya C., Tsuchiya Y., Hatanaka Y., Uchida K., Hohjoh H., and Wada K. (2013) Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as novel potentiator of cyclin-dependent kinases to enhance cell proliferation, independent of its hydrolase activity. J Biol Chem, 288: 12615-12626.
26. *Hohjoh H. (2013) MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells. In MicroRNA Protocols. Methods Mol Biol, 936: 257-269.
27. Shin M., Ohte S., Fukuda T., Sasanuma H., Yoneyama K., Kokabu S., Miyamoto A., Tsukamoto S., Hohjoh H., Jimi E., and Katagiri T. (2013) Identification of a novel bone morphogenetic protein (BMP)-inducible transcript, BMP-inducible transcript-1, by utilizing the conserved BMP-responsive elements in the Id genes. J Bone Miner Metab, 31: 34-43.
28. Takahashi M., Eda A., Fukushima T., and *Hohjoh H. (2012) Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klotho-deficient, senescence-model mouse. PLoS ONE, 7(11): e48974.
29. Hamasaki M., Hashizume Y., Yamada Y., Katayama T., Hohjoh H., Fusaki N., Nakashima Y., Furuya H., Haga N., Takami Y., and Era T. (2012) Pathogenic mutation of ALK2 inhibits iPS cell reprogramming and maintenance: mechanisms of reprogramming and strategy for drug identification. Stem Cells, 30: 2437-2449.
30. Takahashi M., Katagiri T., Furuya H., and *Hohjoh H. (2012) Disease-causing allele specific silencing against the ALK2 mutants, R206H and G356D, in Fibrodysplasia Ossificans Progressiva. Gene Therapy, 19: 781-785.
31. Ohnishi Y., Totoki Y., Toyoda A., Watanabe T., Yamamoto Y., Tokunaga K., Sakaki Y., Sasaki H., and *Hohjoh H. (2012) Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development. Mol Biol Rep, 39: 903-909.
32. Eda A., Takahashi M., Fukushima T., and *Hohjoh H. (2011) Alteration of microRNA expression in the process of mouse brain growth. Gene, 485: 46-52.
33. Takahashi M., Watanabe S., Murata M., Furuya H., Kanazawa I., Wada K., and *Hohjoh H. (2010) Tailor-made RNAi knockdown against triplet repeat disease-causing alleles. Proc Natl Acad Sci USA, 107: 21731-21736.
34. Ohnishi Y., Totoki Y., Toyoda A., Watanabe T., Yamamoto Y., Tokunaga K., Sakaki Y., Sasaki H., and *Hohjoh H. (2010) Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development. Nucl Acids Res, 38: 5141-5151.
35. *Hohjoh H. (2010) Allele-specific silencing by RNA interference. In RNA interference. Methods Mol Biol, 623: 67-79.
36. Eda A., Tamura Y., Yoshida M., and *Hohjoh H. (2009) Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell. BBRC, 388: 648-653.
37. Kitamura K., Itou Y., Yanazawa M., Ohsawa M., Suzuki-Migishima R., Umeki Y., Hohjoh H., Yanagawa Y., Shinba T., Itoh M., Nakamura K., and Goto Y. (2009) Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice. Hum Mol Genet, 18: 3708-3724.
38. *Hohjoh H., Akari H., Fujiwara Y., Tamura Y., Hirai H., and Wada K. (2009) Molecular cloning and characterization of the common marmoset huntingtin gene. Gene, 432: 60-66.
39. Tamura Y., Yoshida M., Ohnishi Y., and *Hohjoh H. (2009) Variation of gene silencing involving endogenous microRNA in mammalian cells. Mol Biol Rep, 36: 1413-1420.
40. Doi Y., Oki S., Ozawa T., Hohjoh H., Miyake S., and Yamamura T. (2008) Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc Natl Acad Sci USA, 105: 8381-8386.
41. Ohnishi Y., Tamura Y., Yoshida M., Tokunaga K., and *Hohjoh H. (2008) Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi. PLoS ONE 3(5): e2248.
42. *Hohjoh H. and Fukushima T. (2007) Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells. BBRC, 362: 360-367.
43. Tamura Y., Kunugi H., Ohashi J. and *Hohjoh H. (2007) The possible association between epigenetic aberration in DNA methylation in RELN and psychiatric disorders. Mol Psychiatry, 12: 519.
44. Tamura Y., Kunugi H., Ohashi J. and *Hohjoh H. (2007) Epigenetic aberration of the human REELIN gene in psychiatric disorders. Mol Psychiatry, 12: 593-600.
45. *Hohjoh H. and Fukushima T. (2007) Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing. Gene, 391: 39-44.
46. Ohashi J., Naka I., Toyoda A., Takasu M., Tokunaga K., Ishida T., Sakaki Y., and *Hohjoh H. (2006) Estimation of the species-specific mutation rates of the DRB1 locus in human and chimpanzee. Tissue Antigens, 68: 427-431.
47. Sakai T. and *Hohjoh H. (2006) Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference. Cell Biol Int, 30: 952-956.
48. Kawashima M., Tamiya G., Oka A., Hohjoh H., Juli T., Ebisawa T., Honda Y., Inoko H., and Tokunaga K. (2006) Genome-wide association analysis of human narcolepsy and a new resistance gene. Am J Hum Genet, 79: 252-263.
49. Ohnishi Y., Tokunaga K., Kaneko K., and *Hohjoh H. (2006) Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles. J RNAi Gene silencing, 2: 154-160.
50. Kawashima M., Ikuta T., Tamiya G., Hohjoh H., Honda Y., Juji T., Tokunaga K., and Inoko H. (2006) Genome-wide association study of narcolepsy: initial screening on chromosome6. In: Dupont J, Hansen JA (eds) HLA 2004: immunobiology of the human MHC. Proceedings of the 13th International Histocompatibility Workshop and Conference. Volume 1 & II, IHWG Press, Seattle, WA, (ISBN 0-945278-03-9).
51. Ohnishi Y., Tokunaga K., and *Hohjoh H. (2005) Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3’- or 5’-end of the sense-stranded siRNA element. BBRC, 329: 516-521.
52. Tamura Y., Sakasegawa Y., Omi K., Kishida H., Asada T., Kimura H., Tokunaga K., Hachiya N.S., Kaneko K., and *Hohjoh H. (2005) Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer’s disease in a Japanese population. Neurosci Letters, 379: 149-151.
53. Sago N., Omi K., Tamura Y., Kunugi H., Toyo-ka T., Tokunaga K., and *Hohjoh H. (2004) RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed. BBRC, 319: 50-57.
54. Omi K., Tokunaga K., and *Hohjoh H. (2004) Long-lasting RNAi activity in mammalian neurons. FEBS letters, 558: 89-95.
55. *Hohjoh H. (2004) Enhancement of RNAi activity by improved siRNA duplexes. FEBS letters, 557: 193-198.
56. *Hohjoh H., Ohashi J., Takasu M., Nishioka T., Ishida T., and Tokunaga K. (2003) Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species. Immunogenetics, 54: 856-861.
57. *Hohjoh H., Takashu M., Shishikura K., Takahashi Y., Honda Y., and Tokunaga K. (2003) Significant association of the arylalkylamine N-acetyltransferase (AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics, 4: 151-153.
58. *Hohjoh H. (2002) RNA interference (RNAi) induction with various types of synthetic oligonucleotide duplexes in cultured human cells. FEBS letters, 521: 195-199.
59. Kawashima M., *Hohjoh H., Terada N., Komata T., Honda Y., and Tokunaga K. (2001) Association studies of the tumor necrosis factor-alpha (TNFA) and its receptor 1 (TNFR1) and 2 (TNFR2) genes with human narcolepsy. Korean J Genet, 23: 365-370.
60. Lapteva N., Ando Y., Nieda M., Hohjoh H., Okai M., Kikuchi A., Dymshits G., Ishikawa Y., Juji T., and Tokunaga K. (2001) Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array. Br J Haematol, 114:191-197.
61. Mignot E., Lin L., Rogers W., Honda Y., Qiu X., Lin X., Okun M., Hohjoh H., Miki T., Hsu S.H., Leffell M.S., Grumet F.C., Fernandex-Vina M., Honda M., and Risch N. (2001) Complex HLA-DR and –DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet, 68: 686-699.
62. *Hohjoh H., Terada N., Nakayama T., Kawashima M., Miyagawa T., Honda Y., and Tokunaga K. (2001) Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB1*1501 and –DQB1*0602. Tissue Antigens, 57: 230-235.
63. *Hohjoh H. and Tokunaga K. (2001) Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter. Genes and Immunity, 2: 105-109.
64. *Hohjoh H., Terada N., Miki T., Honda Y., and Tokunaga K. (2001) Haplotype analyses with the human leukocyte antigen (HLA) and tumor necrosis factor-alpha (TNF-) genes in narcolepsy. Psychiatry Clin Neurosci, 55: 37-39.
65. *Hohjoh H., Terada N., Honda Y., Juji T., and Tokunaga K. (2001) Negative association of the HLA-DRB1*1502-DQB1*0601 haplotype with human narcolepsy. Immunogenetics, 52: 299-301.
66. Chida S., *Hohjoh H., Hirai M., and Tokunaga K. (2001) Haplotype specific sequence encoding protein kinase, interferon-inducible double stranded RNA dependent activator (PRKRA) in the human leukocyte antigen (HLA) class II region. Immunogenetics, 52: 186-194.
67. Takahashi Y., Hohjoh H., and Matsuura K. (2000) Predisposing factors in delayed sleep phase syndrome. Psychiatry Clin Neurosci, 54: 356-358.
68. Akaho R., Matsushita I., Narita K., Okazaki Y., Okabe Y., Matsushita M., Hohjoh H., Tokunaga K., and Sasaki T. (2000) Support for an association between HLA-DR1 and schizophrenia in the Japanese population. Am J Med Genet, 96: 725-727.
69. Miyagawa T., *Hohjoh H., Honda Y., Juji T., and Tokunaga K. (2000) Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy. Immunogenetics, 52: 12-18.
70. *Hohjoh H., Terada N., Kawashima M., Honda Y., and Tokunaga K. (2000) Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene　with human narcolepsy. Tissue Antigens, 56: 446-448.
71. Wu M.S., Tani K., Sugiyama H., Hibino H., Izawa K., Tanabe T., Nakazaki Y., Ishii H., Ohashi J., Hohjoh H., Iseki T., Tojo A., Nakamura Y. Tanioka Y., Tokunaga K., and Asano S. (2000) MHC (major histocompatibility complex)-DRB genes and polymorphisms in common marmoset. J Mol Evol, 51: 214-222.
72. Umino Y., *Hohjoh H., and Tokunaga K. (2000) Novel single nucleotide polymorphisms (SNPs) at positions 497(T/G) and 829(T/C) in the human c-FOS gene and haplotype association. Hum Mutation, 16: 279.
73. Shihikura K., *Hohjoh H., and Tokunaga K. (2000) Novel allele containing a 190(C→T) nonsynonymous substitution in the N-acetyltransferase (NAT2) gene. Hum Mutation, 15: 581.
74. Narita K., Sasaki T., Akaho R., Okazaki Y., Kusumi I., Kato T., Hashimoto O., Fukuda R., Koyama T., Matsuo K., Okabe Y., Nanko S. Hohjoh H. and Tokunaga K. (2000) HLA-DR1 and season of birth in Japanese patients with schizophrenia. Am J Psychiatry, 157: 1173-1175.
75. Chida S., *Hohjoh H., and Tokunaga K. (1999) Molecular analyses of the possible RNA-binding protein gene located in the human leukocyte antigen (HLA)-DR subregion. Gene, 240: 125-132.
76. *Hohjoh H., Nakayama T., Ohashi J., Miyagawa T., Tanaka H., Akaza T., Honda Y., Juji T., and Tokunaga K. (1999) Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-) gene promoter with human narcolepsy. Tissue Antigens, 54: 138-145.
77. *Hohjoh H., Takahashi Y., Hatta Y., Tanaka H., Akaza T., Tokunaga K., Honda Y., and Juli T. (1999) Possible association of human leukocyte antigen DR1 with delayed sleep phase syndrome. Psychiatry Clin Neurosci, 53: 527-529.
78. Chida S., Wakui M., Hohjoh H., Ishikawa Y., Tsuchiya N., Juji T. and Tokunaga K. (1998) A possible new gene encoding and RNA binding protein in the class II region and a MICA-MICB null haplotype in the class I region. In the 10th International Congress of Immunology (Talwar G.P., and Ganguly N.K., eds), pp.39-42, Monduzzi Editore S.p.A, Bologna-Italy.
79. Hohjoh H. and Singer M.F. (1997) Sequence-specific single-strand RNA binding protein encoded by the human LINE-1 retrotransposon. EMBO J, 16: 6034-6043.
80. Hohjoh H. and Singer M.F. (1997) Ribonuclease and high salt sensitivity of the ribonucleoprotein complex formed by the human LINE-1 retrotransposon. J Mol Biol, 271: 7-12.
81. *Hohjoh H. and Singer M.F. (1996) Cytoplasmic ribonucleoprotein complexes containing human LINE-1 protein and RNA. EMBO J, 15: 630-639.
82. Ito T., Hohjoh H., and Sakaki Y. (1993) Pulsed-field polyacrylamide gel electrophoresis: Basic phenomena and applications. Electrophoresis, 14: 278-282.
83. Moriyama K., Nakajima E., Hohjoh H., Asayama R., and Okochi K. (1991) Immunoselected hepatitis B virus mutant. Lancet, Jan 12: 125.
84. Hohjoh H., Minakami R., and Sakaki Y. (1990) Selective cloning and sequence analysis of the human L1 (LINE-1) sequence which transposed in the relatively recent past. Nucl Acids Res, 18: 4099-4104.
85. Sakaki Y. Hohjoh H., Minakami R., Ito T., Hattori M., Fujita A., and Saigo K. (1989) L1 retroposon-like sequence of human genome: structure and evolution. In Highlights of Modern Biochemistry (Kotyk A., Skoda J., Paces V., and Kostka V., eds), pp.559-568, VSP International Science Publishers, Zeist.

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北條 浩彦（ホウジョウ ヒロヒコ）

北條浩彦（ホウジョウヒロヒコ）