HOME ＞ 研究業績詳細
研究業績詳細
堀内 優奈（ホリウチ ユウナ）
| 研究テーマ | DEPDC5関連てんかんの発症メカニズム解析、無細胞系コレステロール引き抜き能測定法の開発 |
|---|---|
| 研究業績（論文） | 1. Horiuchi Y, Lai SJ, Yamazaki A, Nakamura A, Ohkawa R, Yano K, Kameda T, Okubo S, Shimano S, Hagihara M, Tohda S, Tozuka M. Validation and application of a novel cholesterol efflux assay using immobilized liposomes as a substitute for cultured cells. Biosci Rep. 2018;38(2); BSR20180144. 2. Horiuchi Y, Ohkawa R, Lai SJ, Yamazaki A, Ikoma H, Yano K, Kameda T, Tozuka M. Characterization of the cholesterol efflux of apolipoprotein E-containing high-density lipoprotein in THP-1 cells. Biol Chem. 2019; 400 (2): 209-218 3. 大久保滋夫, 堀内優奈, 増山みさき，大川龍之介, 金森きよ子, 川上保子, 戸塚実. 修飾高比重リポタンパクの機能解析と粥状動脈硬化形成との関わり. 文京学院大学総合研究所紀要 2019;19：175-183. 4. Horiuchi Y, Ohkawa R, Lai SJ, Shimano S, Hagihara M, Tohda S, Kameda T, Tozuka M. Usefulness of apolipoprotein B-depleted serum in cholesterol efflux capacity assays using immobilized liposome-bound gel beads. Biosci Rep. 2019;39(4):BSR20190213 5. Lai SJ, Ohkawa R, Horiuchi Y, Kubota T, Tozuka M. Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages. Biol Chem. 2019; 400(12):1593-1602 6. Horiuchi Y, Lai SJ, Kameda T, Tozuka M, Ohkawa R. Comparison of a novel cholesterol efflux assay using immobilized liposome-bound gel beads with the conventional method. Biosci Rep. 2020; 40(8):BSR20201495 7. Ohkawa R, Low H, Mukhamedova N, Fu Y, Lai SJ, Sasaoka M, Hara A, Yamazaki A, Kameda T, Horiuchi Y, Meikle PJ, Pernes G, Lancaster GI, Ditiatkovski M, Nesterl P, Vaisman BL, Sviridov D, Murphy AJ, Remaley AT, Sviridov D, Tozuka M. Cholesterol transport between red blood cells and lipoproteins contributes to cholesterol metabolism in blood. J Lipid Res. 2020; 61(12):1577-1588. 8. Shimano S, Ohkawa R, Nambu M, Sasaoka M, Yamazaki A, Fujii Y, Horiuchi Y, Lai SJ, Kameda T, Ichimura N, Fujita K, Tohda S, Tozuka M. Marked Changes in Serum Amyloid A Distribution and High-Density Lipoprotein Structure during Acute Inflammation. BioMed Res Int. 2021; 9241259 9. Yamazaki A, Ohkawa R, Yamagata Y, Horiuchi Y, Lai SJ, Kameda T, Ichimura N, Tohda S, Tozuka M. Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL). Biol Chem. 2021;402(4): 439-449. 10. Kameda T, Horiuchi Y, Shimano S, Yano K, Lai SJ, Ichimura N, Tohda S, Kurihara Y, Tozuka M, Ohkawa R. Effect of myeloperoxidase oxidation and N-homocysteinylation of high-density lipoprotein on endothelial repair function. Biol Chem. 2021;403(3):265-277. 11. Horiuchi Y, Lai SJ, Kameda T, Tozuka M, Ohkawa R. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: confirmation and improvement for application in clinical laboratory. Ann Clin Biochem. 2022 ;59(2):134-143. 12. 大川龍之介, 堀内優奈, 戸塚実. 固相化リポソーム結合ゲルビーズ法によるコレステロール引き抜き能測定. 日本臨床検査医学会誌. Vol. 70 No. 4: 314-322,2022 13. Mutsuda Y, Miyakoshi T, Horiuchi Y, Kameda T, Tozuka M, Ohkawa R. Development and validation of novel automatable assay for cholesterol efflux capacity. Biosci Rep. 2023 Feb 27;43(2):BSR20221519 14. 堀内 優奈, 大川 龍之介, 戸塚 実. 無細胞系コレステロール引き抜き能測定法の臨床現場での測定に向けた検討. 臨床化学 Vol. 52 No. 2: 97-104, 2023 |
| 研究者 | 教育活動 |