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堀敦詞（ホリアツシ）

研究テーマ	各種疾患の病因・病態機序の解明とバイオマーカーの探索
研究業績（論文）	（2018～2024年の英文原著） (1) Hori A, Inaba H, Hato T, Tanaka K, Sato S, Okamoto M, Horiuchi Y, Paran FJ, Tabe Y, Mori S, Rosales C, Akamatsu W, Murayama T, Kurebayashi N, Sakurai T, Ai T, Miida T. Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease. PLoS One . 2024 Aug 22;19(8):e0291887. (2) Kobori Y, Hirayama S, Fukushima Y, Ueno T, Sekihara K, Hori A, Horiuchi Y, Makino S, Nishioka E, Miida T. Low serum carnitine level is associated with increased urinary carnitine excretion in late pregnancy. Ann Clin Biochem . 2024 Mar 20:45632241239806. (3) Kai T, Hirayama S, Soda S, Fuwa F, Nakagawa S, Ueno T, Hori A, Miida T. Higher concentration of 25-hydroxycholesterol in treatment-naïve patients with type 2 diabetes compared to healthy individuals. J Clin Lipidol. 2023 May-Jun; 17(3): 384-391. (4) Sagara R, Hirayama S, Ueno T, Hori A, Kobori Y, Kai T, Nishioka E, Matsukawa T, Makino S, Miida T. Lipoprotein lipase concentration in umbilical cord blood reflects neonatal birth weight. Clin Chim Acta. 2023 Mar 1; 542: 117275. (5) Castleberry M, Raby CA, Ifrim A, Shibata Y, Matsushita S, Ugawa S, Miura Y, Hori A, Miida T, Linton MF, Michell DL, Tsujita M, Vickers KC. J Lipid Res. 2023 Feb;64(2):100328. (6) Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, Ikeo K, Ruvolo V, Zhang W, Mak PY, Kaczkowski B, Harada H, Katayama K, Sugimoto Y, Myslinski J, Hato T, Miida T, Konopleva M, Hayashizaki Y, Carter BZ, Tabe Y, Andreeff M. Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML. Transl Oncol. 2022 Apr; 18: 101354. (7) Mori S, Hori A, Turker I, Inaji M, Bello-Pardo E, Miida T, Otomo Y, Ai T. Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain? J Am Heart Assoc. 2021 May 4; 10(9): e019778. (8) Hori A, Ishida F, Nakazawa H, Yamaura M, Morita S, Uehara T, Honda T, Hidaka H. Serum sphingomyelin species profile is altered in hematologic malignancies. Clin Chim Acta. 2021 Mar; 514: 29-33. (9) Hori A, Ai T, Isshiki M, Motoi Y, Yano K, Tabe Y, Hattori N, Miida T. Novel Variants in the CLCN1, RYR2, and DCTN1 Found in Elderly Japanese Dementia Patients: A Case Series. Geriatrics (Basel). 2021 Feb 7; 6(1): 14. (10) Nakata R, Uehara T, Iwaya M, Asaka S, Kobayashi S, Sugano M, Higuchi K, Kusama Y, Nakazawa K, Nakaguro M, Kobayashi M, Tateishi A, Makino M, Kawaguchi K, Maejima T, Ishii K, Sano K, Shimojo H, Hori A, Otsuki T, Hamano H, Kawa S, Ota H Immunostaining With Immunoglobulin G Subclass Antibody Cocktail for Diagnosis of Type 1 Autoimmune Pancreatitis. Int J Surg Pathol. 2020 Dec; 28(8): 844-849. (11) Yamatani K, Hirayama S, Seino U, Hirayama A, Hori A, Suzuki K, Idei M, Kitahara M, Miida T. Preβ1-high-density lipoprotein metabolism is delayed in patients with chronic kidney disease not on hemodialysis. J Clin Lipidol. 2020 Sep-Oct; 14(5): 730-739. (12) Nishiie-Yano R, Hirayama S, Tamura M, Kanemochi T, Ueno T, Hirayama A, Hori A, Ai T, Hirose N, Miida T. Hemolysis Is Responsible for Elevation of Serum Iron Concentration After Regular Exercises in Judo Athletes. Biol Trace Elem Res. 2020 Sep;197(1):63-69. (13) Hirayama S, Hori A, Isshiki M, Hirayama A, Ueno T, Tamura Y, Kaga H, Watada H, Kawamori R, Miida T. Fasting serum free glycerol concentration is a potential surrogate marker of visceral obesity and insulin sensitivity in middle-aged Japanese men. J Clin Lipidol. 2020 Jul-Aug; 14(4): 522-530. (14) Yamamoto H, Yasuo M, Komatsu M, Ushiki A, Hamano H, Hori A, Nakajima T, Uehara T, Fujinaga Y, Matsui S, Hanaoka M. Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis. Cytokine. 2019 Aug; 120: 125-129. (15) Hori A, Yamaura M, Morita S, Uehara T, Honda T, Hidaka H. Characterization of galactosyl and lactosyl sulfatide species in human serum by MALDI-TOF mass spectrometry. Ann Clin Biochem. 2019 Sep; 56(5): 574-582.

研究テーマ

各種疾患の病因・病態機序の解明とバイオマーカーの探索

研究業績（論文）

（2018～2024年の英文原著）
(1) Hori A, Inaba H, Hato T, Tanaka K, Sato S, Okamoto M, Horiuchi Y, Paran FJ, Tabe Y, Mori S, Rosales C, Akamatsu W, Murayama T, Kurebayashi N, Sakurai T, Ai T, Miida T. Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer's disease. PLoS One
. 2024 Aug 22;19(8):e0291887.
(2) Kobori Y, Hirayama S, Fukushima Y, Ueno T, Sekihara K, Hori A, Horiuchi Y, Makino S, Nishioka E, Miida T. Low serum carnitine level is associated with increased urinary carnitine excretion in late pregnancy. Ann Clin Biochem
. 2024 Mar 20:45632241239806.
(3) Kai T, Hirayama S, Soda S, Fuwa F, Nakagawa S, Ueno T, Hori A, Miida T. Higher concentration of 25-hydroxycholesterol in treatment-naïve patients with type 2 diabetes compared to healthy individuals. J Clin Lipidol. 2023 May-Jun; 17(3): 384-391.
(4) Sagara R, Hirayama S, Ueno T, Hori A, Kobori Y, Kai T, Nishioka E, Matsukawa T, Makino S, Miida T. Lipoprotein lipase concentration in umbilical cord blood reflects neonatal birth weight. Clin Chim Acta. 2023 Mar 1; 542: 117275.
(5) Castleberry M, Raby CA, Ifrim A, Shibata Y, Matsushita S, Ugawa S, Miura Y, Hori A, Miida T, Linton MF, Michell DL, Tsujita M, Vickers KC. J Lipid Res. 2023 Feb;64(2):100328.
(6) Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, Ikeo K, Ruvolo V, Zhang W, Mak PY, Kaczkowski B, Harada H, Katayama K, Sugimoto Y, Myslinski J, Hato T, Miida T, Konopleva M, Hayashizaki Y, Carter BZ, Tabe Y, Andreeff M. Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML. Transl Oncol. 2022 Apr; 18: 101354.
(7) Mori S, Hori A, Turker I, Inaji M, Bello-Pardo E, Miida T, Otomo Y, Ai T. Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain? J Am Heart Assoc. 2021 May 4; 10(9): e019778.
(8) Hori A, Ishida F, Nakazawa H, Yamaura M, Morita S, Uehara T, Honda T, Hidaka H. Serum sphingomyelin species profile is altered in hematologic malignancies. Clin Chim Acta. 2021 Mar; 514: 29-33.
(9) Hori A, Ai T, Isshiki M, Motoi Y, Yano K, Tabe Y, Hattori N, Miida T. Novel Variants in the CLCN1, RYR2, and DCTN1 Found in Elderly Japanese Dementia Patients: A Case Series. Geriatrics (Basel). 2021 Feb 7; 6(1): 14.
(10) Nakata R, Uehara T, Iwaya M, Asaka S, Kobayashi S, Sugano M, Higuchi K, Kusama Y, Nakazawa K, Nakaguro M, Kobayashi M, Tateishi A, Makino M, Kawaguchi K, Maejima T, Ishii K, Sano K, Shimojo H, Hori A, Otsuki T, Hamano H, Kawa S, Ota H Immunostaining With Immunoglobulin G Subclass Antibody Cocktail for Diagnosis of Type 1 Autoimmune Pancreatitis. Int J Surg Pathol. 2020 Dec; 28(8): 844-849.
(11) Yamatani K, Hirayama S, Seino U, Hirayama A, Hori A, Suzuki K, Idei M, Kitahara M, Miida T. Preβ1-high-density lipoprotein metabolism is delayed in patients with chronic kidney disease not on hemodialysis. J Clin Lipidol. 2020 Sep-Oct; 14(5): 730-739.
(12) Nishiie-Yano R, Hirayama S, Tamura M, Kanemochi T, Ueno T, Hirayama A, Hori A, Ai T, Hirose N, Miida T. Hemolysis Is Responsible for Elevation of Serum Iron Concentration After Regular Exercises in Judo Athletes. Biol Trace Elem Res. 2020 Sep;197(1):63-69.
(13) Hirayama S, Hori A, Isshiki M, Hirayama A, Ueno T, Tamura Y, Kaga H, Watada H, Kawamori R, Miida T. Fasting serum free glycerol concentration is a potential surrogate marker of visceral obesity and insulin sensitivity in middle-aged Japanese men. J Clin Lipidol. 2020 Jul-Aug; 14(4): 522-530.
(14) Yamamoto H, Yasuo M, Komatsu M, Ushiki A, Hamano H, Hori A, Nakajima T, Uehara T, Fujinaga Y, Matsui S, Hanaoka M. Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis. Cytokine. 2019 Aug; 120: 125-129.
(15) Hori A, Yamaura M, Morita S, Uehara T, Honda T, Hidaka H. Characterization of galactosyl and lactosyl sulfatide species in human serum by MALDI-TOF mass spectrometry. Ann Clin Biochem. 2019 Sep; 56(5): 574-582.

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堀 敦詞（ホリ アツシ）

堀敦詞（ホリアツシ）