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研究業績詳細

高橋昌哉（タカハシマサヤ）

研究テーマ	MRIを用いた新規画像診断法の開発
研究業績（論文）	Ohkusa, H. Yoshida, Y. Ono, T. Okafuji, A. Kawakami, O. Ishida, T. Suzuki, M. Takahashi, B. Fritz-Zieroth. 31P-MRS and histological changes of rat liver after intrahepatic arterial injection of lipiodol. Acta Hepatologica Japonica 32, 852-856 (1991) 0.082 T. Akai, M. Takahashi, Y. Nakada, R. Ohnishi, Y. Ikoma, M. Yamaguchi. Anxiolytic effects of lisuride and its agonistic action to central 5-HT1A receptors. Folia Pharmacol Japonica 97, 209-220 (1991) 1.317 M. Takahashi, B. Fritz-Zieroth, M. Yamaguchi, H. Ogawa, T. Tanaka, S. Sasagawa, T. Chikugo, Y. Ohta, K. Okamoto. Magnetic resonance imaging on cerebral disorders with stroke in stroke-prone spontaneously hypertensive rats. Jap. Heart J 33,4;576 (1992) 1.45 M. Takahashi, B. Fritz-Zieroth, M. Yamaguchi, H. Ogawa, T. Tanaka, S. Sasagawa. MR imaging of cerebral lesions accompanying stroke in stroke-prone spontaneously hypertensive rats. Folia Pharmacol Japonica 100, 21-28 (1992) 1.317 M. Takahashi, B. Fritz-Zieroth. Abdominal MRI in rats used with oral Gd-DTPA mixture. Jap Magn Reson Med 13; 1, 60-66 (1993)　 - M. Takahashi, B. Fritz-Zieroth, T. Chikugo, H. Ogawa. In vivo differentiation of edematous changes after stroke in spontaneously hypertensive rats using diffusion weighted MRI. Acta Neurochir (1994) [Suppl] 60: 224-227, NY, Springer-Vertag (1994) 1.881 Ikezaki, T. Nomura, M. Takahashi, B. Fritz-Zieroth, T. M. Fukui. MRI contrast enhancement by Mn-TPPS in experimental rat brain tumor with peripheral benzodiazepine receptors. Neurochir (1994) [Suppl] 60: 353-355, NY, Springer-Vertag (1994) 1.881 M. Takahashi, B. Fritz-Zieroth, T. Chikugo, and H. Ogawa. Differentiation of chronic lesions after stroke in stroke-prone spontaneously hypertensive rats using diffusion weighted MRI. Magn Reson Med 30, 485-488 (1993) 4.668 K. Ikezaki, T. Nomura, M. Takahashi, B. Fritz-Zieroth, T. Inamura, M. Fukui. Selective and prolonged MRI enhancement by Mn-TPPS in an experimental rat brain tumour with peripheral benzodiazepine receptors. Neurol Res 16, 393-397 (1994) 1.983 Y. Ohota, T. Chikugo, T. Suzuki, M. Takahashi, B. Fritz-Zieroth. The therapeutic effect of imidapril on established cerebrovascular lesions in M-SHRSP – successive MRI observations of the healing-process. Jap Heart J 35, 529-529 (1994) 1.45 M. Yamaguchi, K. Sugimachi, K. Nakano, M. Fujimoto, M. Takahashi, T. Chikugo. Memory deficit accompanying cerebral neurodegeneration after stroke in stroke-prone spontaneously hypertensive rats (SHRSP). Acta Neurochir [Suppl] 60, 200-202 (1994) 1.881 M. Takahashi, B. Fritz-Zieroth, Y. Ohta, T. Chikugo. Therapeutic effects of imidapril on cerebral lesions observed by magnetic resonance imaging in malignant stroke-prone spontaneously hypertensive rats. J Hypertens 12, 761-768 (1994) 4.776 K. Harada, J. Yoshida, T. Wakabayashi, K. Sugita, K. Kurisu, T. Uozumi, B. Fritz-Zieroth, M. Takahashi, T. Yamanaka. Antitumor effect of intra-arterial tumor necrosis factor-a in rats with transplanted intracerebral glioma and its evaluation by MRI. Neurological Surgery 23, 1069-1074 (1995) 0.131 Y. Itoh, H. Kandori, M. Takahashi, B. Fritz-Zieroth and N. Miyata.19F-MR imaging of transplanted tumor. Perfluorochemicals as a fluorine tumor imaging agent. Nippon Acta Radiologica 55, 345-347 (1995) - J. Ono, K. Harada, M. Takahashi, M. Maeda, K. Ikenaka, K. Sakurai, N. Sakai, T. Kagawa, B. Fritz-Zieroth, T. Nagai, A. Nihei, S. Hashimoto, S. Okada. Differentiation between dysmyelination and demyelination using magnetic resonance diffusional anisotropy. Brain Res 671,141-148 (1995) 3.125 T. Miyazawa, Y. Aoki, K. Akagi, M. Takahashi, B. Fritz-Zieroth, T. Frenzel, H-J. Weinmann. Application of ZK 150 471, a fluorinated pH probe for 19F-magnetic resonance spectroscopy, to in vivo pH measurement after hyperthermic treatment of tumors in mice. Acad Radiolgy 3 [suppl.], s363-s364 (1996) 2.128 Y. Aoki, K. Akagi, Y. Tanaka, J. Kawai, M. Takahashi. Measurement of intratumor pH by pH indicator used in 19F-MRS : Measurement of extracellular pH decrease caused by hyperthermia combined with hydralazine. Invest Radiol 31, 680-689 (1996) 6.091 M. Fujita, R. Yamamoto, B. Fritz-Zieroth, T. Yamanaka, M. Takahashi, T. Miyazawa, M. Tatsuta, N. Terada, N. Hosomi, E. Inoue, C. Kuroda. Contrast enhancement with Gd-EOB-DTPA in MR imaging of hepatocellular carcinoma in mice: a comparison with superparamagnetic iron oxide. J Magn Reson Imag 6;3, 472-477 (1996) 5.119 M. Takahashi, H. Tsutsui, C. Murayama, T. Miyazawa, B. Fritz-Zieroth. Neurotoxicity of gadolinium contrast agents for magnetic resonance imaging in rats with osmotically disrupted blood-brain barrier. Magn Reson Imaging 14;6, 619-623 (1996) 2.225 M. Shimada, S. Hayashi, A. Senoo, H. Moriya, T. Kogure, T. Nanba, M. Nakagome, T. Miyazawa, M. Takahashi, I. Kaneko, M. Tsubuku. Dynamic MR hepatocholangiography with the SIP Fast GRE (Saturation Inversion Projection Fast Gradient Echo) methods. Nippon Acta Radiologica 57, 681-683 (1997) - Zs. Kovacs, K. Ikezaki, M. Takahashi, J. Kawai, M. Fukui. A chronological evaluation of experimental brain infarct by MRI, with the use of apparent diffusion coefficient and magnetization transfer contrast. Acta Neurochir [Suppl] 70, 43-45 (1997) 1.881 K. Ikezaki, M. Takahashi, H. Koga, J. Kawai, Zs. Kovacs, T. Inamura, M. Fukui. Apparent diffusion coefficient (ADC) and magnetization transfer contrast (MTC) mapping of experiment brain tumor. Acta Neurochir [Suppl] 70, 170-172 (1997) PMID: 9416312 1.881 T. Ishida, T. Murakami, N. Kato, M. Takahashi, T. Miyazawa, K. Tsuda, N. Tomoda, Y. Narumi, H. Nakamura. Superparamagnetic iron oxide enhanced magnetic resonance imaging of rat liver with hepatocellular carcinoma and benign hyperplastic nodule. Invest Radiology 32, 282-287 (1997) 10.065 T. Kim, T. Murakami, Y. Hasuike, M. Goto, N. Kato, M. Takahashi, T. Miyazawa, Y. Narumi, M. Monden, H. Nakamura. Experimental hepatic dysfunction: Evaluation by MR imaging with Gd-EOB-DTPA. J Magn Reson Imag 7, 683-688 (1997) 5.119 M. Fujita, R. Yamamoto, M. Takahashi, T. Tsuji, T. Yamanaka, T. Miyazawa, B. Fritz-Zieroth, N. Terada, C. Kuroda. Paradoxic uptake of Gd-EOB-DTPA by hepatocellular carcinoma in mice: Quantitative image analysis. J Magn Reson Imag 7, 768-770 (1997) 5.119 N. Kato, M. Takahashi, S. Ihara, T. Tsujimoto, T. Miyazawa. Efficacy and safety of liver-specific MRI contrast agents in rats with hepatitis and cirrhosis. Academic Radiology 5 [Suppl], s83-s85 (1998) 2.128 S. Hirohashi, R. Hirohashi, H. Uchida, S. Kitano, M. Akira, W. Ono, H. Ohishi, N. Katoh, M. Takahashi, T. Miyazawa. Optimal dose of hepatobiliary contrast agent for MR cholangiography: experimental study in rat. J Magn Reson Imag 8, 847-852 (1998) 5.119 J. Kawai, M. Takahashi, K. Takashima, T. Miyazawa. Comparison of 1.0 molar and 0.5 molar formulation of Gd-DO3A-butrol in dynamic MR study in the liver with hepatocellular carcinoma in rats. Magn Reson Imaging 17, 91-97 (1999) 2.225 M. Takahashi, F. W. Wehrli, S. L. Wehrli, S. N. Hwang, M. W. Lundy, J. H. Hartke, B. Borah. Effect of prostaglandin and bisphosphonate on cancellous bone volume and structure in the ovariectomized rat studied by quantitative 3D NMR microscopy. J Bone Miner Res 14, 680-689 (1999) 6.284 F. Yabuuchi, M. Takahashi, K. Aritake, M. Fujimoto, H. Ito, M. Tsuzaki, T. Akai, M. Yamaguchi, S. Hayashi, Y. Nishino, M. Braeutigam. Post-stroke treatment with imidapril reduces learning deficits with less formation of brain oedema in a stroke-prone substrain of spontaneous hypertensive rats. Fundam Clin Pharm (Arch Int Pharmaco Ther) 13, 475-483 (1999) 2.319 N. Kato, M. Takahashi, T. Tsuji, S. Ihara, M. Brautigam, T. Miyazawa. Dose-dependency and rate of decay of efficacy of Resovist on MR images in a rat chirrhotic liver model. Invest Radiology 34, 551-557 (1999) 10.065 M. Takahashi, F. W. Wehrli, S. N. Hwang, S. L. Wehrli. Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model. Magn Reson Imaging 18, 33-39 (2000) 2.225 M. Takahashi, J. Ono, K. Harada, M. Maeda, D. B. Hackney. Diffusional anisotropy in cranial nerves with maturation: Quantitative evaluation by diffusion magnetic resonance imaging in rats. Radiology 216, 881-885 (2000) 29.146 H. Uematsu, L. Dougherty, M. Takahashi, Y. Ohno, M. Nakatsu, H.K. Song, V. A. Ferrari, W. B. Gefter, M. D. Schnalle, H. Hatabu. Pulmonary MR angiography with contrast agent at 4 Tesla: A preliminary result. Magn Reson Med 46, 1028-1030 (2001) 4.668 E. D. Schwartz, C. L. Chin, M. Takahashi, S. N. Hwang, D. B. Hackney. Diffusion-weighted imaging of the spinal cord. In: Melhem E, editor. Neuroimaging Clinics of North America. Philadelphia: W.B. Saunders Company 12:1, 125-146 (2002) PMID: 11998249 1.325 A. C. Wright, S. L. Wehrli, G. Zhang, M. Takahashi, D. B. Hackney, M. E. Selzer, F. W. Wehrli. Visualization of individual axons in excised lamprey spinal cord by magnetic resonance microscopy. J Neurosci Methods 114, 9-15 (2002) 2.554 C. L. Chin, F. W. Wehrli, S. N. Hwang, M. Takahashi, D. B. Hackney. Bi-exponential diffusion attenuation in the rat spinal cord: Computer simulations based on anatomic images of Axonal Architecture. Magn Reson Med 47, 455-460 (2002) 4.668 M. Takahashi, F. W. Wehrli, L. Hilaire, B. S. Zemel, S. N. Hwang. In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure. Proc Natl Acad Sci USA 99, 4574-4579 (2002) 12.779 M. Takahashi, D. B. Hackney, G. Zhang, S. L. Wehrli, A. C. Wright, W. T. O'Brien, F. W. Wehrli, M. E. Selzer. Magnetic resonance microimaging of intra-axonal water diffusion in live excised lamprey spinal cord. Proc Natl Acad Sci USA 99:16192-16196 (2002) 12.779 H. Uematsu, T. Matsuda, M. Takahashi, H. Inoue, K. Hayashi, H. Yamada, Y. Yonekura, H. Itoh. Susceptibility induced changes in signal intensity from spin echo versus gradient echo sequences. Clin Imaging 26:367-370 (2002) 1.015 M. Takahashi, H. Uematsu, H. Hatabu. MR imaging at high magnetic fields. (invited review) Eur J Radiolo 46(1):45-52 (2002) 2.462 H. Uematsu, L. Dougherty, M. Takahashi, N. S. Butler, H-K. Song, Y. Ohno, W. B. Gefter, M. D. Schnall, H. Hatabu. A direct comparison of signal behavior between 4.0 and 1.5 T: A phantom study. Eur J Radiolo 45(2):154-159 (2003) 2.462 H. Uematsu, L. Dougherty, M. Takahashi, Y. Ohno, M. Nakatsu, M. D. Schnall, H. Hatabu. Abdominal imaging at 4 T MR system: a preliminary result. Eur J Radiolo 47:161-163 (2003) 2.462 I. Hasegawa, H. Uematsu, J. C. Gee, P. Rogelj, H. K. Song, M. Nakatsu, M. Takahashi, W. B. Gefter, H. Hatabu. Voxelwise mapping of magnetic resonance ventilation-perfusion ratio in a porcine model by multimodality registration: technical note. Acad Radiol;10:1091-1096 (2003) PMID: 14587627 2.128 M. A. Fernandez-Seara, S. L. Wehrli, M. Takahashi, F. W. Wehrli. Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties. J Bone Miner Res 19:289-96 (2004) 6.284 S. Kwei, G. Stavrakis, M. Takahashi, G. Taylor, M. J. Folkman, M. A. Jr. Gimbrone, G. Garcia-Cardena. Early adaptive responses of the vascular wall during venous arterialization in mice. Am J Pathol; 164:81-9 (2004) 4.057 H. Uematsu, A. Popescu, G. Zhang, A. C. Wright, S. L. Wehrli, M. Takahashi, F. W. Wehrli, M. E. Selzer, D. B. Hackney. Magnetization Transfer Micro MR Imaging of Live Excised Lamprey Spinal Cord: Characterization and Immunohistochemical Correlation. Am J Neuroradiol; 25:1816–1820 (2004) 3.55 H. Uematsu, M. Takahashi, L. Dougherty, H. Hatabu. High field body MR imaging: Preliminary Experience. Clinical Imaging; 28:159-162 (2004) 1.136 M. Takahashi, F. W. Wehrli. Micro MRI of trabecular bone. [Invited review] Clin Calcium 14(12): 47-54 (2004) 0.27 O. Szentirmai, C. H. Baker, N. Lin, S. Szuccs, M. Takahashi, S. Kiryu, A. L. Kung, R. C. Mulligan, B. S. Carter. Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect. Neurosurg; 58:365-372 (2006) 4.889 M. M. Murray, K. P. Spindler, C. Devin, B. S. Snyder, J. Muller, M. Takahashi, P. Ballard, L. B. Nanney, D. Zurakowski. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res; 24:820-830 (2006) 2.692 S. Kubo, E. Levantini, S. Kobayashi, O. Kocher, B. Halmos, D. G. Tenen, M. Takahashi. Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice. Magn Reson Med 56, 698-703 (2006) PMID: 16902979 4.668 M. Kuroki, M. Nishino, M. Takahashi, Y. Mori, V. D. Raptopoulos, P. M. Boiselle, S. Tamura, H. Hatabu. Incidence of pulmonary embolism in younger versus older patients using CT. J Thorac Imaging; 21(2):167-171 (2006) PMID: 16770233 2.01 T. Kubo, Y. Ohno, S. Gautam, P.-JP. Lin, H.U. Kauczor, H. Hatabu, M. Takahashi, M. Nishino, A. Sitek, D. Takenaka, M. Nogami, H. Koyama, J. Ley-Zaporozhan, W. Stiller, S. Ley, H. Inokawa, M. Okumura, Y. Fujisawa, H. Kura, T. Rifu, V. Raptopoulos, K. Sugimura. Use of 3D adaptive raw-data filter in CT of the lung: Effect on radiation dose reduction. Am J Roent (AJR) 191(4): W167-174 (2008) 6.582 T. Kubo, M. Nishino, A. Kino, N. Yoshimura, P-J P. Lin, M. Takahashi, V. D. Raptopoulos, H. Hatabu. Three dimensional-adaptive raw-data filter: Evaluation in low dose chest MDCT. J Comput Assist Tomogr 30(6);933-938 (2006) 2.081 M. Takahashi, P. K. Saha, F. W. Wehrli. Skeletal effects of short-term exposure to dexamethasone and response to risedronate treatment studied in vivo in rabbits by magnetic resonance micro-imaging and spectroscopy. J bone Miner Metb 24(6):467-475 (2006) 2.976 S. Kiryu, S. H. Loring, Y. Mori, N. M. Rofsky, H. Hatabu, M. Takahashi. Quantitative analysis of diaphragmatic motion: Dynamic MRI in different postures. Magn Reson Imag 24: 1325-1332 (2006) 3.13 C. Sawamura, M. Takahashi, K. J. McCarthy, Z. Shen, N. Fukai, E. K. Rodriguez, B. D. Snyder. Effect of in-ovo immobilization on development of chick hind limb articular cartilage: An evaluation using micro MRI measurement of delayed gadolinium uptake. Magn Reson Med 56(6):1235-1241 (2006) 4.668 J. Neal, M. Takahashi, M. Silva, G. Tiao, C. A. Walsh, V. L. Sheen. Insights into the gyrification of developing ferret brain by magnetic resonance imaging. J Anat 210: 66-77 (2007) 2.183 D. Li, H. Ji, S. Zaghlul, K. McNamara, M. C. Liang, T. Shimamura, S. Kubo, M. Takahashi, L. R. Chirieac, R. F. Padera, A. M. Scott, A. A. Jungbluth, W. K. Cavenee, L. J. Old, G. D. Demetri, Kwok-Kin Wong. Therapeutic anti-EGFR antibody 806 generates responses in murine De Novo EGFR mutant-dependent lung carcinomas. J Clin Invest 117:346-352 (2007) 19.477 S. Kubo, E. Tadamura, M. Yamamoto, S. Kanao, M. L. Kataoka, M. Takahashi, T. Kimura, T. Kita, M. Komeda, K. Togashi. Multidetector-row computed tomographic angiography of thoracic and abdominal aortic aneurysms: comparison of arterial enhancement with 3 different doses of contrast material. J Comput Assist Tomogr. 31:422-429 (2007) 2.081 D. Li, T. Shimamura, H. Ji, L. Chen, H. J. Haringsma, K. McNamara, M. Liang, S. A. Perera, S, Zaghlul, C. L. Borgman, S. Kubo, M. Takahashi, Y. Sun, L. R. Chirieac, R. F. Padera, N. Lindeman, P. A. Jänne, R. K. Thomas, M. L. Meyerson, M. J. Eck, J. A. Engelman, G. I. Shapiro, K. Wong. Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell 12: 81-93 (2007) 38.585 H. Uematsu, M. Takahashi, H. Hatabu, C Chin, S. L. Wehrli, F. W. Wehrli, T. Asakura. Changes in T1 and T2 observed in brain MR imaging with delivery of high concentrations of oxygen. J Comput Assist Tomogr 31:662-665 (2007) 1.394 M. Eikermann, P. Fassbender, A. Malhotra, M. Takahashi, S. Kubo, A. Jordan, D. P. White1, N. L. Chamberlin. Unwarranted administration of acetylcholinesterase Inhibitors can impair genioglossus and diaphragm muscle function. Anesthesiology 107: 621-629 (2007) 5.66 M. Takahashi, S. Kubo, S. Kiryu, J. C. Gee, H. Hatabu. MR microscopy of the lung in small rodents (invited review) Eur J Radiolo 64: 367-374 (2007) 4.531 A. Kino, M. Takahashi, S. K. Ashiku, M. M. Decamp, R.E. Lenkinski, H. Hatabu. Optimal breathing protocol for dynamic contrast-enhanced MRI of solitary pulmonary nodules at 3T. Eur J Radiolo 64: 397-400 (2007) 4.531 S. Kiryu, T. A. Sundaram, S. Kubo, T. Asakura, H. Hatabu, J. C. Gee, M. Takahashi. MRI assessment of lung parenchymal motion in normal mice and transgenic mice with sickle cell disease. JMRI 27: 49-56 (2008) PMID: 18050323 5.119 T. Kubo, P-J. P. Lin, W. Stiller, M. Takahashi, H-U. Kauczor, Y. Ohno H. Hatabu. Radiation dose reduction in chest CT: A review. Am J Roent (AJR) 190(2):335-343 (2008) PMID: 18806144 6.582 M. Kalamarides, A. O. Stemmer-Rachamimov, M. Takahashi, Z-Y Han, F. Chareyre, M-N. Kawakita, P. M. Black, R. S. Carroll. Natural history of meningioma development in mice reveals a synergy of Nf2 and p16Ink4a mutations. Brain Pathology 18:6 2-70 (2008) 7.611 O. Szentirmai, C. H. Baker, S. S. Bullain, N. Lin, M. Takahashi, R. C. Mulligan, B. S. Carter. Successful inhibition of intracranial human glioblastoma xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble VEGF-receptor-2. J Neurosurg 108(5):979-988 (2008) 5.526 D. Li, L. Ambrogio, T. Shimamura, S. Kubo, M. Takahashi, L. R. Chirieac, R. F. Padera, G. I. Shapiro, A. Baum, F. Himmelsbach, W. J. Rettig, M. Meyerson, F. Solca, H. Greulich, Kwok-Kin Wong. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 7;27(34):4702-4711 (2008) 8.756 T. Shimamura, D. Li, H. Ji, H. J. Haringsma, E. Liniker, C. L. Borgman, A. M. Lowell, Y. Minami, K. McNamara, S. A. Perera, S. Zaghlul, R. K. Thomas, H. Greulich, S. Kobayashi, L. R. Chirieac, R. F. Padera, S. Kubo, M. Takahashi, D. G. Tenen, M. Meyerson, K-K. Wong, G. I. Shapiro. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res. 68:5827-5838 (2008) 13.312 L. Degoricija, P. N. Bansal, S. H. Sontjens, N. S. Joshi, M. Takahashi, B. Snyder, M. W. Grinstaff. Hydrogels for Osteochondral repair based on photocrosslinkable carbamate dendrimers. Biomacromolecules. 9:2863-2872 (2008) 6.979 S. A. Perera, D. Li, T. Shimamura, M. G. Raso, H. Ji, L. Chen, C. L. Borgman, S. Zaghlul, K. A. Brandstetter, S. Kubo, M. Takahashi, L. R. Chirieac, R. F. Padera, R. T. Bronson, G. I. Shapiro, H. Greulich, M. L. Meyerson, U. Guertler, P. G. Chesa, F. Solca, I. I. Wistuba, Kwok-Kin. Wong. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci USA 13;106: 474-479 (2009) 9.4 Y. Kusakari, C-Y. Xiao, N. Himes, S. D. Kinsella, M. Takahashi, A. Rosenzweig, T. Matsui. Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction. Interactive CardioVascular and Thoracic Surgery 9: 951-955 (2009) PMID: 19776081; PMCID: PMC2877192 1.857 J. Kim, M. Böhlke, K. Thompson, M. Takahashi, S. Phattanarudee, T. Maher, M. Wessling-Resnick. Effect of iron status on olfactory uptake of manganese and its distribution in the brain. FASEB J 23 (Suppl):921 (2009) 4.966 C. Khemtong, C. W. Kessinger, O. Togao, M. Takahashi, J. Gao. Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles. Proc IEEE Eng Med Biol Soc. 2009:4095-4097 (2009) 0.91 T. Mani, G. Tircso, O. Togao, P. Zhao, T. Soesbe, M. Takahashi, A. D. Sherry. Modulation of water exchange in Eu(III) DOTA–tetraamide complexes: considerations for in vivo imaging of PARACEST agents. Contrast Media & Molecular Imaging 14: 183-191 (2009) 3.307 O. Togao, S. Doi, M. Kuro-o, T. Masaki, N. Yorioka, M. Takahashi. Assessment of renal fibrosis by diffusion weighted MR imaging: A study using a murine unilateral ureteral obstruction (UUO) model. Radiology 255:772-780 (2010) 29.146 C.M. Contreras, T.D. Gallardo, J.M. Haynie, E.A. Akbay, S. Sharma, O. Togao, N Bardeesy, M. Takahashi, J. Settleman, K. Wong, D.H. Castrillon. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Models Mech 3:181-193 (2010) 5.732 O. Togao, R. Tsuji, Y. Ohno, I. Dimitrov, M. Takahashi. Ultra-short echo time (UTE) MRI of the lung: Assessment of tissue density in the lung parenchyma. Magn Reson Med 64: 1491-1498 (2010) M. Takahashi, O. Togao, M. Obara, M. van Cauteren, Y. Ohno, S. Doi, M. Kuro-o, C. Malloy, C.C. Hsia, I. Dimitrov. Ultra-short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice. J Magn Reson Imag 32:326-333 (2010) C. W. Kessinger, C. Khemtong, O. Togao, M. Takahashi, B. D. Sumer, J. Gao. In vivo angiogenesis imaging of solid tumors by alpha v beta 3 - targeted, dual-modality micellar nanoprobes. Exp Biol Med 235(8):957-965 (2010) PMID: 20660096 S. Doi, Y. Zou, O. Togao, J. V. Pastor, G. B. John, L. Wang, K. Shiizaki, R. Gotschall, S. Schiavi, N. Yorioka, M. Takahashi, D. A. Boothman, M. Kuro-o. Klotho inhibits transforming growth factor-1 (TGF-1) signaling and suppresses renal fibrosis and cancer metastasis in mice. JBC 11:8655-65 (2011) C. Khemtong, O. Togao, J. Ren, C. W. Kessinger, M. Takahashi, A. D. Sherry, J. Gao. Off-resonance saturation MRI of superparamagnetic nanoprobes: Theoretical models and experimental validations. JMR 209:53-60 (2011) C. W. Kessinger, O. Togao, C. Khemtong, G. Huang, M. Takahashi, J. Gao. Investigation of in vivo targeting kinetics of αvβ3-specific superparamagnetic nanoprobes by time-resolved MRI. Theranostics 1:263-273 (2011) Y. Ohno, H. Koyama, K. Matsumoto, Y. Onishi, D. Takenaka, N. Aoyama, T. Yoshikawa, Y. Ishimura, M. Takahashi, K. Sugimura. T2 measurements of 3-T MRI with ultra-short TE: Capabilities of pulmonary functional assessment and clinical stage classification in smokers. Am J Roent (AJR) 197:w279-285 (2011) O. Togao, Y. Ohno, I. Dimitrov, C.C. Hsia, M. Takahashi. Ventilation/Perfusion imaging of the lung using ultra-short echo time (UTE) MRI in an animal model of pulmonary embolism. JMRI 34:539-546 (2011) PMID: 21761465 K. E. Sakaie, M. Takahashi, I. Dimitrov, O. Togao, S.L. Davis, G. Remington, A. Conger, D. Conger, T. Frohman, R. Fox, E.M. Frohman. Diffusion tensor imaging the medial longitudinal fasciculus in INO: Opportunities and challenges. Ann NY Acad Sci 1233:307-312 (2011) PMID: 21951009 C. Yilmaz, N. J. Tustison, D. M. Dane, P. Ravikumar, M. Takahashi, J. C. Gee, C. C.W. Hsia. Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography. J Appl Physiolo 111:1150-1158 (2011) PMCID: PMC3191793 I. Marin-Valencia, S. K. Cho, T. Mashimo, L. B. Good, A. Jindal, K. J. Hatanpaa, V. Vemireddy, P. Kapur, D. Rakheja, X. Sun, B. Mickey, J. M. Pascual, C. Choi, M. Takahashi, O. Togao, R. J. DeBerardinis, E. A. Maher, C. R. Malloy, R. M. Bachoo. Glucose metabolism via the pentose phosphate pathway, glycolysis and citric acid cycle in an orthotopic mouse model of human brain tumors. NMR Biomed 25(10):1177-1186 (2012) PMID: 22383401, PMCID: PMC3670098 S-T Lo, K. Sagiyama, J-M Ahn, M. Takahashi, X. Sun. MRI-aided PET imaging of pancreatic β-cell mass changes in mice. J Nucl Med. 53 (Suppl):1583 (2012) T. C. Soesbe, O. Togao, M. Takahashi, A.D. Sherry. SWIFT-CEST: A new MRI method to overcome T(2) shortening caused by PARACEST contrast agents. Magn Reson Med 68(3):816-821 (2012) PMID: 22213371, PMCID: PMC3422602 J. Kim, M. Y. Li, P. D. Bucket, M. Böhlke, K. J. Thompson, M. Takahashi, T. Maher, M. Wessling-Resnick. Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency. PLoS ONE 2012;7(3):e33533 (2012) T. Aoyagi, Y. Kusakari, C-Y. Xia, M. Takahashi, B. T. Inouye, M. Scherrer-Crosbie, A. Rosenzweig, K. Hara, T. Matsui. Cardiac mTOR protects the heart against ischemia-reperfusion injury. AJP-Heart and Circulatory Physiology 303:H75-H85, (2012) doi:10.1152, PMID: 22561297 A. S. Wadajkar, J.U. Menon, K. Kangasniemi, T. Dobin, L. Gandee, M. Takahashi, J-T. Hsieh, K. T. Nguyen. Prostate cancer-specific thermo-responsive polymer-coated Iron oxide nanoparticles. Biomaterials 34:3618-3625 (2013) Y Ohno, M. Nishino, H. Koyama, K. Matsumoto, Y. Onishi, D. Takenaka, N. Aoyama, T. Yoshikawa, Y. Nishimura, M. Takahashi, K. Sugimura. Pulmonary MR imaging with ultra-short TEs: Utility for disease severity assessment of connective tissue disease patients. Eur J Radiolo 20;1-7 (2013) doi:pii: S0720-048X(13) 00119-8 PMID: 23523024 S. Zhang, K. Zhou, G. Huang, M. Takahashi, A. D. Sherry, J. Gao. A novel class of polymeric pH-responsive MRI CEST agents. Chem Commun., 49 (57): 6418 - 6420 (2013) PMID: 23752496, PMCID: PMC3712501 X. Huang, G. Huang, S. Zhang, K. Sagiyama, O. Togao, X. Ma, Y. Wang, Y. Li, T. C. Soesbe, B. D. Sumer, M. Takahashi, A. D. Sherry, J. Gao. Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes. Angew. Chem. Int. Ed. 52: 1–6 (2013) PMID: 23788453, PMCID: PMC3771347 V. Tumati, S. Mathur, K. Song, J-T. Hsieh, D. Zhao, M. Takahashi, T. Dobin, L. Gandee, T.D. Solberg, A.A. Habib, D. Saha. Development of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapy. Int J Oncol 42:1613-9 (2013). doi: 10.3892/ijo.2013.1858 O. Togao, C. W. Kessinger, G. Huang, T. C. Soesbe, K. Sagiyama, I. Dimitrov, D. A. Sherry, J. Gao, M. Takahashi. Characterization of lung cancer by amide proton transfer (APT) imaging: An in-vivo study in an orthotopic mouse model. PLoS One 8(10):e77019 (2013). doi: 10.1371/journal.pone.0077019. PMID: 24143199 O. Togao, T. Yoshiura, J. Keupp, A. Hiwatashi, K. Yamashita, K. Kikuchi, Y. Suzuki, S. O. Suzuki, T. Iwaki, N. Hata, M. Mizoguchi, K. Yoshimoto, K. Sagiyama, M. Takahashi, H. Honda. Amide proton transfer imaging of diffuse gliomas: Correlation with histopathological grades. Neuro-Oncol 16(3):441-448 (2014). Dec 4. [Epub ahead of print] PMID: 24305718 K. Sagiyama, T. Mashimo, O. Togao, V. Vemireddy, K. J. Hatanpaa, E. Maher, B. E. Mickey, E. Pan, A. D. Sherry, R. Bachoo, M. Takahashi. In vivo chemical exchange saturation transfer (CEST) imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci USA 25;111(12):4542-4547 (2014) doi: 10.1073/pnas.1323855111, PMID: 24616497 K. Sakaie, M. Takahashi, K. Sagiyama, I. Dimitrov, T. Frohman, G. Remington, E. M. Frohman, R. Fox. Clinical/scientific notes: Injury to a specific neural pathway detected by ultra-high-field MRI. Neurology 82:182-183. (2014) PMID: 24285615, PMCID: PMC3897439 [Available on 2015/1/14] Y Ohno, H. M. Nishino, K. Koyama, D. Takenaka, M. Takahashi, T. Yoshikawa, S. Matsumoto, M. Obara, Van Cauteren, K. Sugimura. Pulmonary MR imaging with ultra-short TEs: Utility for disease severity assessment of connective tissue disease patients. Eur J Radiolo, 82(8): 1359-1369 (2013) Y. Ohno, M. Nishio, H. Koyama, T. Yoshikawa, S. Matsumoto, S. Seki, M. Obara, M. van Cauteren, M. Takahashi, K. Sugimura K. Pulmonary 3 T MRI with ultrashort TEs: influence of ultrashort echo time interval on pulmonary functional and clinical stage assessments of smokers. J Magn Reson Imaging. 39(4):988-97 (2014). doi: 10.1002/jmri.24232. PMID: 24123342 A. Kumar, S. Zhang, G. Hao, G. Hassan, S. Ramezani, K. Sagiyama, S-T. Lo, M. Takahashi, A. D. Sherry, O. K. Öz, Z. Kovacs, X. Sun. Molecular platform for design and synthesis of targeted dual-modality imaging probes. Bioconjugate Chem. 18; 26(3): 549–558 (2015) doi: 10.1021/acs.bioconjchem.5b00028, PMCID: PMC4428032 M.C. Hu, M. Shi, H.J. Cho, B. Adams-Huet, J. Paek, J. Shleton, A. P. Amaral, C. Faul, M. Taniguchi, M. Wolf, M. Brand, M. Takahashi, M. Kuro-o, J. A. Hill, O.W. Moe. Klotho and phosphate: Modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrology 26(6): 1290–1302 (2015) PMCID: PMC4446876 O. Togao, T. Yoshiura, J. Keupp, A. Hiwatashi, K. Yamashita, K. Kikuchi, Y. Suzuki, M. J. Kruiskamp, K. Sagiyama, M. Takahashi, H. Honda. Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors. JMRI 42(5): 1346-1353 (2015) doi: 10.1002/jmri.24895 O. Togao, A. Hiwatashi, J. Keupp, K. Yamashita, K. Kikuchi, M. Yoneyama, M.J. Kruiskamp, K. Sagiyama, T. Yoshiura, M. Takahashi, H. Honda. Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique. Plos-One 11(5): e0155925 (2016) PMCID: PMC4881971 P. Ravikumar, J. U. Menon, P. Punnakitikashem, D. Gyawali, O. Togao, M. Takahashi, J. Zhang, J. Ye, O. W. Moe, K. T. Nguyen, C. C. W. Hsia. Nanoparticle facilitated inhalational delivery of erythropoietin receptor cDNA protects against hyperoxic lung injury. Nanomedicine: Nanotechnology, Biology, and Medicine; NBM 12(3):811-21. doi: 10.1016, (2016) PMID:26518603, PMCID:PMC4809756 K. Sakaie, M. Takahashi, G. Remington, X. Wang, A Conger, D Conger, I. Dimitrov, S. Jones, A Frohman, T. Frohman, K. Sagiyama, O. Togao, R. Fox, E. Frohman. Correlating function and imaging measures of the medial longitudinal fasciculus. Pros-One 11(1): e0147863 (2016) PMCID: PMC4723147 T. Kubo, Y. Ohno,D. Takenaka, M. Nishino, S. Gautam, K. Sugimura, H. U. Kauczor, H. Hatabu, P.-J. Lin, M. Takahashi, A. Sitek, M. Nogami, H. Koyama, J. Ley-Zaporozhan, W. Stiller, S. Ley, H. Inokawa, Y. Fujikawa, H. Kura, V. Raptopoulos. Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization-iLEAD study. Euro J Radiol 3:67-73 (2016) M. C. Hu, M. Shi, J. Zhang, T. Addo, H. J. Cho, S. L. Barker, P. Ravikumar, N. Gillings, A. Bian, S. S. Sidhu, M. Takahashi, M. Kuro-o, O. W. Moe. Renal production, uptake, and handling of circulating αKlotho. J Am Soc Nephrol; 27(1): 79–90 (2016). doi: 10.1681/ASN.2014101030, PMCID:PMC4696570 M. A. Yousuf, C. Tan, M. I. Torres-Altoro, F. –M. Lu, E. Plaitz, S. Zhang, M. Takahashi, A. Hernandez, S. G. Kernie, F. Plattner, J. A. Bibb. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. J Neurochemistry 1; 317-327 (2016) O. Togao, A. Hiwatashi, K. Yamashita, K. Kikuchi, J. Keupp, K. Yoshimoto, D. Kuga, M. Yoneyama, S. O. Suzuki, T. Iwaki, M. Takahashi, K. Iihara, H. Honda. Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. Eur Radiol; 27(2): 578-588 (2017) doi: 10.1007/s00330-016-4328-0 M. C. Hu, M. Shi, N. Gillings, B. Flores, M. Takahashi, M. Kuro-o, O. W. Moe. Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy. Kidney Intr 91 (5): 1104-1114 (2017) B. D. Newton, K. Wright, M. D. Winkler, F. Bovis, M. Takahashi, I. E. Dimitrov, M. Pia Sormani, M. C. Pinho, D. T. Okuda. Three-dimensional shape and surface features contrast multiple sclerosis from Non-Specific white matter disease. J Neuroimaging 27 (6): 613-619 (2017) PMID: 28488804, doi: 10.1111/jon.12449. R. Z. Hussain, W. A. Miller-Little, D. Lambracht-Washington, T. C. Jaramillo, M. Takahashi, S. Zhang, C. Castro-Rojas, K. Deason, M. Fu, L. Hayardeny, C. M. Powell, R. N. Rosenberg, O. Stüve. Laquinimod has no effects on brain volume or cellular CNS composition in the F1 3xTg-AD/C3H mouse model of Alzheimer's disease. J Neuroimmunol 309: 100–110 (2017) K. Kikuchi, K. Ishimatsu, S. Zhang, I. E. Dimitrov, H. Honda, A. D. Sherry, M. Takahashi. Presaturation power adjusted pulsed (PPAP)-CEST: A method to increase independence of target CEST signals. Contrast Media& Molecular Imaging (CMMI) 2018; 1-11 (2018) ID: 3141789 PMCID: PMC5964408, PMID: 29853805, doi: 10.1155/2018/3141789 K. Gong, G. Guo, D. E. Gerber, B. Gao, M. Peyton, C. Huang, J. D. Minna, K. J. Hatanpaa, K. Kernstine, L. Cai, Y. Xie, H. Zhu, F. J. Fattah, S. Zhang, M. Takahashi, B. Mukherjee, S. Burma, J. Dowell, K. Dao, V. A. Papadimitrakopoulou, V. Olivas, T. G. Bivona, M. MA, K. Politi, D. Zhao, A. A. Habib. TNF drives an adaptive response that mediates resistance to EGFR inhibition in lung cancer. Journal of Clinical Investigation: JCI;128(6):2500-2518. (2018) https://doi.org/10.1172/JCI96148 S. K. Park, T. R. Rosenthal, J. S. Williams, J. M. Shelton, M. Takahashi, S. Zhang. I. A. Bobulescu. Metabolic and cardiovascular effects of chronic mild hyperuricemia in rodents. J Invest Med 66;1037-1044 (2018) doi: 10.1136/jim-2018-000729. Y. Ohno, M. Takahashi, H. Koyama, T. Yoshioka, Challenge of using 3T MR system and whole-body MRI for lung imaging. KAUCZER H-. U., WEILPUTZ M. O. 2nd ed. Switzerland: Springer; 2018: 479-505. K. Pozo, S. Zahler, K. Ishimatsu, A. M. Carter, R. Telange, C. Tan, S. Wang, R. Pfragner, J. Fujimoto, E. G. Grubbs, M. Takahashi, S. C. Oltmann, J. A. Bibb. Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer. Oncotarget 9 (102): 37662–37675, 2018 Dec 28. doi: 10.18632/oncotarget.26480, PMCID: PMC6340867 N. Pandey, J. U. Menon, M. Takahashi, J. T. Hsieh, J. Yang, K. T. Nguyen, A. S. Wadajkar. Thermo-responsive fluorescent nanoparticles for multimodal imaging and treatment of cancers. Nanotheranostics. 1;4(1):1-13 (2020). doi: 10.7150/ntno.39810. eCollection (2020). A. M. Carter , C. Tan, K. Pozo, R. Telange, R. Molinaro, A. Guo, E. De Rosa, J. O. Martinez, S. Zhang, N. Kumar, M. Takahashi, T. Wiederhold, H. K. Ghayee, S. C. Oltmann, K. Pacak, E. A. Woltering, K. J. Hatanpaa, F. E. Nwariaku, E. G. Grubbs, A. J. Gill, B. Robinson, F. Gillardon, S. Reddy, R. Jaskula-Sztul1, J. A. Mobley, M. S. Mukhtar, E. Tasciotti, H. Chen, J. A. Bibb. Phosphoprotein-based biomarkers as predictors for cancer therapy. Proc Natl Acad Sci USA 117 (31) 18401-18411 (2020) M. C. Hu, M. Shi, H. J- Cho, M.Takahashi, M. Mohammadi, and O. W. Moe . C-Terminal fragment of fibroblast growth factor (FGF)-23 improves heart function in murine models of high intact FGF23. AJP-Renal Physiol 326:F584-F599 (2024) X. Wang, K. Ishimatsu, J. Li, X. Wen, W. Ou, A. Anwar, J. Chaudhary, M. Takahashi, A. Dean Sherry and I. R. Corbin. APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage. Hepatic Oncology, 11:1, 2389031 (2024) K. Ishimatsu, K. Kikuchi, O. W. Moe, K. Oshio, K. Ishigami, M. Takahashi. Evaluation of renal perfusion: A comparative study between intravoxel incoherent motion (IVIM) imaging and arterial spin labeling (ASL) to assess renal blood flow in rodents. MRMS (online-2024 https://doi.org/10.2463/mrms.mp.2023-0169) T. Urushihata, M. Takahashi, M. Shimojo, Y. Takado, N. Nitta, Y. Tajima, K. Masamoto,a,, I. Kanno, Y. Tomita,N. Sahara, M. Takahashi, T. Obata, H. Ito, T. Yamashita,T. Suhara, M. Higuchi, H. Takuwa Neuronal deterioration associated with hyperexcitability under mild chronic cerebral hypoperfusion. JCBFM (accepted)

研究テーマ

MRIを用いた新規画像診断法の開発

研究業績（論文）

Ohkusa, H. Yoshida, Y. Ono, T. Okafuji, A. Kawakami, O. Ishida, T. Suzuki, M. Takahashi, B. Fritz-Zieroth. 31P-MRS and histological changes of rat liver after intrahepatic arterial injection of lipiodol. Acta Hepatologica Japonica 32, 852-856 (1991) 0.082
T. Akai, M. Takahashi, Y. Nakada, R. Ohnishi, Y. Ikoma, M. Yamaguchi. Anxiolytic effects of lisuride and its agonistic action to central 5-HT1A receptors. Folia Pharmacol Japonica 97, 209-220 (1991) 1.317
M. Takahashi, B. Fritz-Zieroth, M. Yamaguchi, H. Ogawa, T. Tanaka, S. Sasagawa, T. Chikugo, Y. Ohta, K. Okamoto. Magnetic resonance imaging on cerebral disorders with stroke in stroke-prone spontaneously hypertensive rats. Jap. Heart J 33,4;576 (1992) 1.45
*M. Takahashi, B. Fritz-Zieroth, M. Yamaguchi, H. Ogawa, T. Tanaka, S. Sasagawa. MR imaging of cerebral lesions accompanying stroke in stroke-prone spontaneously hypertensive rats. Folia Pharmacol Japonica 100, 21-28 (1992) 1.317
M. Takahashi, B. Fritz-Zieroth. Abdominal MRI in rats used with oral Gd-DTPA mixture. Jap Magn Reson Med 13; 1, 60-66 (1993)　 -
M. Takahashi, B. Fritz-Zieroth, T. Chikugo, H. Ogawa. In vivo differentiation of edematous changes after stroke in spontaneously hypertensive rats using diffusion weighted MRI. Acta Neurochir (1994) [Suppl] 60: 224-227, NY, Springer-Vertag (1994) 1.881
Ikezaki, T. Nomura, M. Takahashi, B. Fritz-Zieroth, T. M. Fukui. MRI contrast enhancement by Mn-TPPS in experimental rat brain tumor with peripheral benzodiazepine receptors. Neurochir (1994) [Suppl] 60: 353-355, NY, Springer-Vertag (1994) 1.881
M. Takahashi, B. Fritz-Zieroth, T. Chikugo, and H. Ogawa. Differentiation of chronic lesions after stroke in stroke-prone spontaneously hypertensive rats using diffusion weighted MRI. Magn Reson Med 30, 485-488 (1993) 4.668
K. Ikezaki, T. Nomura, M. Takahashi, B. Fritz-Zieroth, T. Inamura, M. Fukui. Selective and prolonged MRI enhancement by Mn-TPPS in an experimental rat brain tumour with peripheral benzodiazepine receptors. Neurol Res 16, 393-397 (1994) 1.983
Y. Ohota, T. Chikugo, T. Suzuki, M. Takahashi, B. Fritz-Zieroth. The therapeutic effect of imidapril on established cerebrovascular lesions in M-SHRSP – successive MRI observations of the healing-process. Jap Heart J 35, 529-529 (1994) 1.45
M. Yamaguchi, K. Sugimachi, K. Nakano, M. Fujimoto, M. Takahashi, T. Chikugo. Memory deficit accompanying cerebral neurodegeneration after stroke in stroke-prone spontaneously hypertensive rats (SHRSP). Acta Neurochir [Suppl] 60, 200-202 (1994) 1.881
M. Takahashi, B. Fritz-Zieroth, Y. Ohta, T. Chikugo. Therapeutic effects of imidapril on cerebral lesions observed by magnetic resonance imaging in malignant stroke-prone spontaneously hypertensive rats. J Hypertens 12, 761-768 (1994) 4.776
K. Harada, J. Yoshida, T. Wakabayashi, K. Sugita, K. Kurisu, T. Uozumi, B. Fritz-Zieroth, M. Takahashi, T. Yamanaka. Antitumor effect of intra-arterial tumor necrosis factor-a in rats with transplanted intracerebral glioma and its evaluation by MRI. Neurological Surgery 23, 1069-1074 (1995) 0.131
Y. Itoh, H. Kandori, M. Takahashi, B. Fritz-Zieroth and N. Miyata.19F-MR imaging of transplanted tumor. Perfluorochemicals as a fluorine tumor imaging agent. Nippon Acta Radiologica 55, 345-347 (1995) -
J. Ono, K. Harada, M. Takahashi, M. Maeda, K. Ikenaka, K. Sakurai, N. Sakai, T. Kagawa, B. Fritz-Zieroth, T. Nagai, A. Nihei, S. Hashimoto, S. Okada. Differentiation between dysmyelination and demyelination using magnetic resonance diffusional anisotropy. Brain Res 671,141-148 (1995) 3.125
T. Miyazawa, Y. Aoki, K. Akagi, M. Takahashi, B. Fritz-Zieroth, T. Frenzel, H-J. Weinmann. Application of ZK 150 471, a fluorinated pH probe for 19F-magnetic resonance spectroscopy, to in vivo pH measurement after hyperthermic treatment of tumors in mice. Acad Radiolgy 3 [suppl.], s363-s364 (1996) 2.128
Y. Aoki, K. Akagi, Y. Tanaka, J. Kawai, M. Takahashi. Measurement of intratumor pH by pH indicator used in 19F-MRS : Measurement of extracellular pH decrease caused by hyperthermia combined with hydralazine. Invest Radiol 31, 680-689 (1996) 6.091
M. Fujita, R. Yamamoto, B. Fritz-Zieroth, T. Yamanaka, M. Takahashi, T. Miyazawa, M. Tatsuta, N. Terada, N. Hosomi, E. Inoue, C. Kuroda. Contrast enhancement with Gd-EOB-DTPA in MR imaging of hepatocellular carcinoma in mice: a comparison with superparamagnetic iron oxide. J Magn Reson Imag 6;3, 472-477 (1996) 5.119
M. Takahashi, H. Tsutsui, C. Murayama, T. Miyazawa, B. Fritz-Zieroth. Neurotoxicity of gadolinium contrast agents for magnetic resonance imaging in rats with osmotically disrupted blood-brain barrier. Magn Reson Imaging 14;6, 619-623 (1996) 2.225
M. Shimada, S. Hayashi, A. Senoo, H. Moriya, T. Kogure, T. Nanba, M. Nakagome, T. Miyazawa, M. Takahashi, I. Kaneko, M. Tsubuku. Dynamic MR hepatocholangiography with the SIP Fast GRE (Saturation Inversion Projection Fast Gradient Echo) methods. Nippon Acta Radiologica 57, 681-683 (1997) -
Zs. Kovacs, K. Ikezaki, M. Takahashi, J. Kawai, M. Fukui. A chronological evaluation of experimental brain infarct by MRI, with the use of apparent diffusion coefficient and magnetization transfer contrast. Acta Neurochir [Suppl] 70, 43-45 (1997) 1.881
K. Ikezaki, M. Takahashi, H. Koga, J. Kawai, Zs. Kovacs, T. Inamura, M. Fukui. Apparent diffusion coefficient (ADC) and magnetization transfer contrast (MTC) mapping of experiment brain tumor. Acta Neurochir [Suppl] 70, 170-172 (1997) PMID: 9416312 1.881
T. Ishida, T. Murakami, N. Kato, M. Takahashi, T. Miyazawa, K. Tsuda, N. Tomoda, Y. Narumi, H. Nakamura. Superparamagnetic iron oxide enhanced magnetic resonance imaging of rat liver with hepatocellular carcinoma and benign hyperplastic nodule. Invest Radiology 32, 282-287 (1997) 10.065
T. Kim, T. Murakami, Y. Hasuike, M. Goto, N. Kato, M. Takahashi, T. Miyazawa, Y. Narumi, M. Monden, H. Nakamura. Experimental hepatic dysfunction: Evaluation by MR imaging with Gd-EOB-DTPA. J Magn Reson Imag 7, 683-688 (1997) 5.119
M. Fujita, R. Yamamoto, M. Takahashi, T. Tsuji, T. Yamanaka, T. Miyazawa, B. Fritz-Zieroth, N. Terada, C. Kuroda. Paradoxic uptake of Gd-EOB-DTPA by hepatocellular carcinoma in mice: Quantitative image analysis. J Magn Reson Imag 7, 768-770 (1997) 5.119
N. Kato, M. Takahashi, S. Ihara, T. Tsujimoto, T. Miyazawa. Efficacy and safety of liver-specific MRI contrast agents in rats with hepatitis and cirrhosis. Academic Radiology 5 [Suppl], s83-s85 (1998) 2.128
S. Hirohashi, R. Hirohashi, H. Uchida, S. Kitano, M. Akira, W. Ono, H. Ohishi, N. Katoh, M. Takahashi, T. Miyazawa. Optimal dose of hepatobiliary contrast agent for MR cholangiography: experimental study in rat. J Magn Reson Imag 8, 847-852 (1998) 5.119
J. Kawai, M. Takahashi, K. Takashima, T. Miyazawa. Comparison of 1.0 molar and 0.5 molar formulation of Gd-DO3A-butrol in dynamic MR study in the liver with hepatocellular carcinoma in rats. Magn Reson Imaging 17, 91-97 (1999) 2.225
M. Takahashi, F. W. Wehrli, S. L. Wehrli, S. N. Hwang, M. W. Lundy, J. H. Hartke, B. Borah. Effect of prostaglandin and bisphosphonate on cancellous bone volume and structure in the ovariectomized rat studied by quantitative 3D NMR microscopy. J Bone Miner Res 14, 680-689 (1999) 6.284
F. Yabuuchi, M. Takahashi, K. Aritake, M. Fujimoto, H. Ito, M. Tsuzaki, T. Akai, M. Yamaguchi, S. Hayashi, Y. Nishino, M. Braeutigam. Post-stroke treatment with imidapril reduces learning deficits with less formation of brain oedema in a stroke-prone substrain of spontaneous hypertensive rats. Fundam Clin Pharm (Arch Int Pharmaco Ther) 13, 475-483 (1999) 2.319
N. Kato, M. Takahashi, T. Tsuji, S. Ihara, M. Brautigam, T. Miyazawa. Dose-dependency and rate of decay of efficacy of Resovist on MR images in a rat chirrhotic liver model. Invest Radiology 34, 551-557 (1999) 10.065
M. Takahashi, F. W. Wehrli, S. N. Hwang, S. L. Wehrli. Relationship between cancellous bone induced magnetic field and ultrastructure in a rat ovariectomy model. Magn Reson Imaging 18, 33-39 (2000) 2.225
M. Takahashi, J. Ono, K. Harada, M. Maeda, D. B. Hackney. Diffusional anisotropy in cranial nerves with maturation: Quantitative evaluation by diffusion magnetic resonance imaging in rats. Radiology 216, 881-885 (2000) 29.146
H. Uematsu, L. Dougherty, M. Takahashi, Y. Ohno, M. Nakatsu, H.K. Song, V. A. Ferrari, W. B. Gefter, M. D. Schnalle, H. Hatabu. Pulmonary MR angiography with contrast agent at 4 Tesla: A preliminary result. Magn Reson Med 46, 1028-1030 (2001) 4.668
E. D. Schwartz, C. L. Chin, M. Takahashi, S. N. Hwang, D. B. Hackney. Diffusion-weighted imaging of the spinal cord. In: Melhem E, editor. Neuroimaging Clinics of North America. Philadelphia: W.B. Saunders Company 12:1, 125-146 (2002) PMID: 11998249 1.325
A. C. Wright, S. L. Wehrli, G. Zhang, M. Takahashi, D. B. Hackney, M. E. Selzer, F. W. Wehrli. Visualization of individual axons in excised lamprey spinal cord by magnetic resonance microscopy. J Neurosci Methods 114, 9-15 (2002) 2.554
C. L. Chin, F. W. Wehrli, S. N. Hwang, M. Takahashi, D. B. Hackney. Bi-exponential diffusion attenuation in the rat spinal cord: Computer simulations based on anatomic images of Axonal Architecture. Magn Reson Med 47, 455-460 (2002) 4.668
M. Takahashi, F. W. Wehrli, L. Hilaire, B. S. Zemel, S. N. Hwang. In vivo NMR microscopy allows short-term serial assessment of multiple skeletal implications of corticosteroid exposure. Proc Natl Acad Sci USA 99, 4574-4579 (2002) 12.779
M. Takahashi, D. B. Hackney, G. Zhang, S. L. Wehrli, A. C. Wright, W. T. O'Brien, F. W. Wehrli, M. E. Selzer. Magnetic resonance microimaging of intra-axonal water diffusion in live excised lamprey spinal cord. Proc Natl Acad Sci USA 99:16192-16196 (2002) 12.779
H. Uematsu, T. Matsuda, M. Takahashi, H. Inoue, K. Hayashi, H. Yamada, Y. Yonekura, H. Itoh. Susceptibility induced changes in signal intensity from spin echo versus gradient echo sequences. Clin Imaging 26:367-370 (2002) 1.015
*M. Takahashi, H. Uematsu, H. Hatabu. MR imaging at high magnetic fields. (invited review) Eur J Radiolo 46(1):45-52 (2002) 2.462
H. Uematsu, L. Dougherty, M. Takahashi, N. S. Butler, H-K. Song, Y. Ohno, W. B. Gefter, M. D. Schnall, H. Hatabu. A direct comparison of signal behavior between 4.0 and 1.5 T: A phantom study. Eur J Radiolo 45(2):154-159 (2003) 2.462
H. Uematsu, L. Dougherty, M. Takahashi, Y. Ohno, M. Nakatsu, M. D. Schnall, H. Hatabu. Abdominal imaging at 4 T MR system: a preliminary result. Eur J Radiolo 47:161-163 (2003) 2.462
I. Hasegawa, H. Uematsu, J. C. Gee, P. Rogelj, H. K. Song, M. Nakatsu, M. Takahashi, W. B. Gefter, H. Hatabu. Voxelwise mapping of magnetic resonance ventilation-perfusion ratio in a porcine model by multimodality registration: technical note. Acad Radiol;10:1091-1096 (2003) PMID: 14587627 2.128
M. A. Fernandez-Seara, S. L. Wehrli, M. Takahashi, F. W. Wehrli. Water content measured by proton-deuteron exchange NMR predicts bone mineral density and mechanical properties. J Bone Miner Res 19:289-96 (2004) 6.284
S. Kwei, G. Stavrakis, M. Takahashi, G. Taylor, M. J. Folkman, M. A. Jr. Gimbrone, G. Garcia-Cardena. Early adaptive responses of the vascular wall during venous arterialization in mice. Am J Pathol; 164:81-9 (2004) 4.057
H. Uematsu, A. Popescu, G. Zhang, A. C. Wright, S. L. Wehrli, M. Takahashi, F. W. Wehrli, M. E. Selzer, D. B. Hackney. Magnetization Transfer Micro MR Imaging of Live Excised Lamprey Spinal Cord: Characterization and Immunohistochemical Correlation. Am J Neuroradiol; 25:1816–1820 (2004) 3.55
H. Uematsu, M. Takahashi, L. Dougherty, H. Hatabu. High field body MR imaging: Preliminary Experience. Clinical Imaging; 28:159-162 (2004) 1.136
*M. Takahashi, F. W. Wehrli. Micro MRI of trabecular bone. [Invited review] Clin Calcium 14(12): 47-54 (2004) 0.27
O. Szentirmai, C. H. Baker, N. Lin, S. Szuccs, M. Takahashi, S. Kiryu, A. L. Kung, R. C. Mulligan, B. S. Carter. Noninvasive bioluminescence imaging of luciferase expressing intracranial U87 xenografts: correlation with magnetic resonance imaging determined tumor volume and longitudinal use in assessing tumor growth and antiangiogenic treatment effect. Neurosurg; 58:365-372 (2006) 4.889
M. M. Murray, K. P. Spindler, C. Devin, B. S. Snyder, J. Muller, M. Takahashi, P. Ballard, L. B. Nanney, D. Zurakowski. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res; 24:820-830 (2006) 2.692
S. Kubo, E. Levantini, S. Kobayashi, O. Kocher, B. Halmos, D. G. Tenen, M. Takahashi. Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice. Magn Reson Med 56, 698-703 (2006) PMID: 16902979 4.668
M. Kuroki, M. Nishino, M. Takahashi, Y. Mori, V. D. Raptopoulos, P. M. Boiselle, S. Tamura, H. Hatabu. Incidence of pulmonary embolism in younger versus older patients using CT. J Thorac Imaging; 21(2):167-171 (2006) PMID: 16770233 2.01
T. Kubo, Y. Ohno, S. Gautam, P.-JP. Lin, H.U. Kauczor, H. Hatabu, M. Takahashi, M. Nishino, A. Sitek, D. Takenaka, M. Nogami, H. Koyama, J. Ley-Zaporozhan, W. Stiller, S. Ley, H. Inokawa, M. Okumura, Y. Fujisawa, H. Kura, T. Rifu, V. Raptopoulos, K. Sugimura. Use of 3D adaptive raw-data filter in CT of the lung: Effect on radiation dose reduction. Am J Roent (AJR) 191(4): W167-174 (2008) 6.582
T. Kubo, M. Nishino, A. Kino, N. Yoshimura, P-J P. Lin, M. Takahashi, V. D. Raptopoulos, H. Hatabu. Three dimensional-adaptive raw-data filter: Evaluation in low dose chest MDCT. J Comput Assist Tomogr 30(6);933-938 (2006) 2.081
M. Takahashi, P. K. Saha, F. W. Wehrli. Skeletal effects of short-term exposure to dexamethasone and response to risedronate treatment studied in vivo in rabbits by magnetic resonance micro-imaging and spectroscopy. J bone Miner Metb 24(6):467-475 (2006) 2.976
S. Kiryu, S. H. Loring, Y. Mori, N. M. Rofsky, H. Hatabu, M. Takahashi. Quantitative analysis of diaphragmatic motion: Dynamic MRI in different postures. Magn Reson Imag 24: 1325-1332 (2006) 3.13
C. Sawamura, M. Takahashi, K. J. McCarthy, Z. Shen, N. Fukai, E. K. Rodriguez, B. D. Snyder. Effect of in-ovo immobilization on development of chick hind limb articular cartilage: An evaluation using micro MRI measurement of delayed gadolinium uptake. Magn Reson Med 56(6):1235-1241 (2006) 4.668
J. Neal, M. Takahashi, M. Silva, G. Tiao, C. A. Walsh, V. L. Sheen. Insights into the gyrification of developing ferret brain by magnetic resonance imaging. J Anat 210: 66-77 (2007) 2.183
D. Li, H. Ji, S. Zaghlul, K. McNamara, M. C. Liang, T. Shimamura, S. Kubo, M. Takahashi, L. R. Chirieac, R. F. Padera, A. M. Scott, A. A. Jungbluth, W. K. Cavenee, L. J. Old, G. D. Demetri, Kwok-Kin Wong. Therapeutic anti-EGFR antibody 806 generates responses in murine De Novo EGFR mutant-dependent lung carcinomas. J Clin Invest 117:346-352 (2007) 19.477
S. Kubo, E. Tadamura, M. Yamamoto, S. Kanao, M. L. Kataoka, M. Takahashi, T. Kimura, T. Kita, M. Komeda, K. Togashi. Multidetector-row computed tomographic angiography of thoracic and abdominal aortic aneurysms: comparison of arterial enhancement with 3 different doses of contrast material. J Comput Assist Tomogr. 31:422-429 (2007) 2.081
D. Li, T. Shimamura, H. Ji, L. Chen, H. J. Haringsma, K. McNamara, M. Liang, S. A. Perera, S, Zaghlul, C. L. Borgman, S. Kubo, M. Takahashi, Y. Sun, L. R. Chirieac, R. F. Padera, N. Lindeman, P. A. Jänne, R. K. Thomas, M. L. Meyerson, M. J. Eck, J. A. Engelman, G. I. Shapiro, K. Wong. Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell 12: 81-93 (2007) 38.585
H. Uematsu, M. Takahashi, H. Hatabu, C Chin, S. L. Wehrli, F. W. Wehrli, T. Asakura. Changes in T1 and T2 observed in brain MR imaging with delivery of high concentrations of oxygen. J Comput Assist Tomogr 31:662-665 (2007) 1.394
M. Eikermann, P. Fassbender, A. Malhotra, M. Takahashi, S. Kubo, A. Jordan, D. P. White1, N. L. Chamberlin. Unwarranted administration of acetylcholinesterase Inhibitors can impair genioglossus and diaphragm muscle function. Anesthesiology 107: 621-629 (2007) 5.66
*M. Takahashi, S. Kubo, S. Kiryu, J. C. Gee, H. Hatabu. MR microscopy of the lung in small rodents (invited review) Eur J Radiolo 64: 367-374 (2007) 4.531
A. Kino, M. Takahashi, S. K. Ashiku, M. M. Decamp, R.E. Lenkinski, H. Hatabu. Optimal breathing protocol for dynamic contrast-enhanced MRI of solitary pulmonary nodules at 3T. Eur J Radiolo 64: 397-400 (2007) 4.531
S. Kiryu, T. A. Sundaram, S. Kubo, T. Asakura, H. Hatabu, J. C. Gee, *M. Takahashi. MRI assessment of lung parenchymal motion in normal mice and transgenic mice with sickle cell disease. JMRI 27: 49-56 (2008) PMID: 18050323 5.119
T. Kubo, P-J. P. Lin, W. Stiller, M. Takahashi, H-U. Kauczor, Y. Ohno H. Hatabu. Radiation dose reduction in chest CT: A review. Am J Roent (AJR) 190(2):335-343 (2008) PMID: 18806144 6.582
M. Kalamarides, A. O. Stemmer-Rachamimov, M. Takahashi, Z-Y Han, F. Chareyre, M-N. Kawakita, P. M. Black, R. S. Carroll. Natural history of meningioma development in mice reveals a synergy of Nf2 and p16Ink4a mutations. Brain Pathology 18:6 2-70 (2008) 7.611
O. Szentirmai, C. H. Baker, S. S. Bullain, N. Lin, M. Takahashi, R. C. Mulligan, B. S. Carter. Successful inhibition of intracranial human glioblastoma xenograft growth via systemic adenoviral delivery of soluble endostatin and soluble VEGF-receptor-2. J Neurosurg 108(5):979-988 (2008) 5.526
D. Li, L. Ambrogio, T. Shimamura, S. Kubo, M. Takahashi, L. R. Chirieac, R. F. Padera, G. I. Shapiro, A. Baum, F. Himmelsbach, W. J. Rettig, M. Meyerson, F. Solca, H. Greulich, Kwok-Kin Wong. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 7;27(34):4702-4711 (2008) 8.756
T. Shimamura, D. Li, H. Ji, H. J. Haringsma, E. Liniker, C. L. Borgman, A. M. Lowell, Y. Minami, K. McNamara, S. A. Perera, S. Zaghlul, R. K. Thomas, H. Greulich, S. Kobayashi, L. R. Chirieac, R. F. Padera, S. Kubo, M. Takahashi, D. G. Tenen, M. Meyerson, K-K. Wong, G. I. Shapiro. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance. Cancer Res. 68:5827-5838 (2008) 13.312
L. Degoricija, P. N. Bansal, S. H. Sontjens, N. S. Joshi, M. Takahashi, B. Snyder, M. W. Grinstaff. Hydrogels for Osteochondral repair based on photocrosslinkable carbamate dendrimers. Biomacromolecules. 9:2863-2872 (2008) 6.979
S. A. Perera, D. Li, T. Shimamura, M. G. Raso, H. Ji, L. Chen, C. L. Borgman, S. Zaghlul, K. A. Brandstetter, S. Kubo, M. Takahashi, L. R. Chirieac, R. F. Padera, R. T. Bronson, G. I. Shapiro, H. Greulich, M. L. Meyerson, U. Guertler, P. G. Chesa, F. Solca, I. I. Wistuba, Kwok-Kin. Wong. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci USA 13;106: 474-479 (2009) 9.4
Y. Kusakari, C-Y. Xiao, N. Himes, S. D. Kinsella, M. Takahashi, A. Rosenzweig, T. Matsui. Myocyte injury along myofibers in left ventricular remodeling after myocardial infarction. Interactive CardioVascular and Thoracic Surgery 9: 951-955 (2009) PMID: 19776081; PMCID: PMC2877192 1.857
J. Kim, M. Böhlke, K. Thompson, M. Takahashi, S. Phattanarudee, T. Maher, M. Wessling-Resnick. Effect of iron status on olfactory uptake of manganese and its distribution in the brain. FASEB J 23 (Suppl):921 (2009) 4.966
C. Khemtong, C. W. Kessinger, O. Togao, M. Takahashi, J. Gao. Off-resonance saturation magnetic resonance imaging of superparamagnetic polymeric micelles. Proc IEEE Eng Med Biol Soc. 2009:4095-4097 (2009) 0.91
T. Mani, G. Tircso, O. Togao, P. Zhao, T. Soesbe, M. Takahashi, A. D. Sherry. Modulation of water exchange in Eu(III) DOTA–tetraamide complexes: considerations for in vivo imaging of PARACEST agents. Contrast Media & Molecular Imaging 14: 183-191 (2009) 3.307
O. Togao, S. Doi, M. Kuro-o, T. Masaki, N. Yorioka, M. Takahashi. Assessment of renal fibrosis by diffusion weighted MR imaging: A study using a murine unilateral ureteral obstruction (UUO) model. Radiology 255:772-780 (2010) 29.146
C.M. Contreras, T.D. Gallardo, J.M. Haynie, E.A. Akbay, S. Sharma, O. Togao, N Bardeesy, M. Takahashi, J. Settleman, K. Wong, D.H. Castrillon. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Models Mech 3:181-193 (2010) 5.732
O. Togao, R. Tsuji, Y. Ohno, I. Dimitrov, M. Takahashi. Ultra-short echo time (UTE) MRI of the lung: Assessment of tissue density in the lung parenchyma. Magn Reson Med 64: 1491-1498 (2010)
M. Takahashi, O. Togao, M. Obara, M. van Cauteren, Y. Ohno, S. Doi, M. Kuro-o, C. Malloy, C.C. Hsia, I. Dimitrov. Ultra-short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice. J Magn Reson Imag 32:326-333 (2010)
C. W. Kessinger, C. Khemtong, O. Togao, M. Takahashi, B. D. Sumer, J. Gao. In vivo angiogenesis imaging of solid tumors by alpha v beta 3 - targeted, dual-modality micellar nanoprobes. Exp Biol Med 235(8):957-965 (2010) PMID: 20660096
S. Doi, Y. Zou, O. Togao, J. V. Pastor, G. B. John, L. Wang, K. Shiizaki, R. Gotschall, S. Schiavi, N. Yorioka, M. Takahashi, D. A. Boothman, M. Kuro-o. Klotho inhibits transforming growth factor-1 (TGF-1) signaling and suppresses renal fibrosis and cancer metastasis in mice. JBC 11:8655-65 (2011)
C. Khemtong, O. Togao, J. Ren, C. W. Kessinger, M. Takahashi, A. D. Sherry, J. Gao. Off-resonance saturation MRI of superparamagnetic nanoprobes: Theoretical models and experimental validations. JMR 209:53-60 (2011)
C. W. Kessinger, O. Togao, C. Khemtong, G. Huang, M. Takahashi, J. Gao. Investigation of in vivo targeting kinetics of αvβ3-specific superparamagnetic nanoprobes by time-resolved MRI. Theranostics 1:263-273 (2011)
Y. Ohno, H. Koyama, K. Matsumoto, Y. Onishi, D. Takenaka, N. Aoyama, T. Yoshikawa, Y. Ishimura, M. Takahashi, K. Sugimura. T2* measurements of 3-T MRI with ultra-short TE: Capabilities of pulmonary functional assessment and clinical stage classification in smokers. Am J Roent (AJR) 197:w279-285 (2011)
O. Togao, Y. Ohno, I. Dimitrov, C.C. Hsia, M. Takahashi. Ventilation/Perfusion imaging of the lung using ultra-short echo time (UTE) MRI in an animal model of pulmonary embolism. JMRI 34:539-546 (2011) PMID: 21761465
K. E. Sakaie, M. Takahashi, I. Dimitrov, O. Togao, S.L. Davis, G. Remington, A. Conger, D. Conger, T. Frohman, R. Fox, E.M. Frohman. Diffusion tensor imaging the medial longitudinal fasciculus in INO: Opportunities and challenges. Ann NY Acad Sci 1233:307-312 (2011) PMID: 21951009
C. Yilmaz, N. J. Tustison, D. M. Dane, P. Ravikumar, M. Takahashi, J. C. Gee, C. C.W. Hsia. Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography. J Appl Physiolo 111:1150-1158 (2011) PMCID: PMC3191793
I. Marin-Valencia, S. K. Cho, T. Mashimo, L. B. Good, A. Jindal, K. J. Hatanpaa, V. Vemireddy, P. Kapur, D. Rakheja, X. Sun, B. Mickey, J. M. Pascual, C. Choi, M. Takahashi, O. Togao, R. J. DeBerardinis, E. A. Maher, C. R. Malloy, R. M. Bachoo. Glucose metabolism via the pentose phosphate pathway, glycolysis and citric acid cycle in an orthotopic mouse model of human brain tumors. NMR Biomed 25(10):1177-1186 (2012) PMID: 22383401, PMCID: PMC3670098
S-T Lo, K. Sagiyama, J-M Ahn, M. Takahashi, X. Sun. MRI-aided PET imaging of pancreatic β-cell mass changes in mice. J Nucl Med. 53 (Suppl):1583 (2012)
T. C. Soesbe, O. Togao, M. Takahashi, A.D. Sherry. SWIFT-CEST: A new MRI method to overcome T(2) shortening caused by PARACEST contrast agents. Magn Reson Med 68(3):816-821 (2012) PMID: 22213371, PMCID: PMC3422602
J. Kim, M. Y. Li, P. D. Bucket, M. Böhlke, K. J. Thompson, M. Takahashi, T. Maher, M. Wessling-Resnick. Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency. PLoS ONE 2012;7(3):e33533 (2012)
T. Aoyagi, Y. Kusakari, C-Y. Xia, M. Takahashi, B. T. Inouye, M. Scherrer-Crosbie, A. Rosenzweig, K. Hara, T. Matsui. Cardiac mTOR protects the heart against ischemia-reperfusion injury. AJP-Heart and Circulatory Physiology 303:H75-H85, (2012) doi:10.1152, PMID: 22561297
A. S. Wadajkar, J.U. Menon, K. Kangasniemi, T. Dobin, L. Gandee, M. Takahashi, J-T. Hsieh, K. T. Nguyen. Prostate cancer-specific thermo-responsive polymer-coated Iron oxide nanoparticles. Biomaterials 34:3618-3625 (2013)
Y Ohno, M. Nishino, H. Koyama, K. Matsumoto, Y. Onishi, D. Takenaka, N. Aoyama, T. Yoshikawa, Y. Nishimura, M. Takahashi, K. Sugimura. Pulmonary MR imaging with ultra-short TEs: Utility for disease severity assessment of connective tissue disease patients. Eur J Radiolo 20;1-7 (2013) doi:pii: S0720-048X(13) 00119-8 PMID: 23523024
S. Zhang, K. Zhou, G. Huang, M. Takahashi, A. D. Sherry, J. Gao. A novel class of polymeric pH-responsive MRI CEST agents. Chem Commun., 49 (57): 6418 - 6420 (2013) PMID: 23752496, PMCID: PMC3712501
X. Huang, G. Huang, S. Zhang, K. Sagiyama, O. Togao, X. Ma, Y. Wang, Y. Li, T. C. Soesbe, B. D. Sumer, M. Takahashi, A. D. Sherry, J. Gao. Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes. Angew. Chem. Int. Ed. 52: 1–6 (2013) PMID: 23788453, PMCID: PMC3771347
V. Tumati, S. Mathur, K. Song, J-T. Hsieh, D. Zhao, M. Takahashi, T. Dobin, L. Gandee, T.D. Solberg, A.A. Habib, D. Saha. Development of a locally advanced orthotopic prostate tumor model in rats for assessment of combined modality therapy. Int J Oncol 42:1613-9 (2013). doi: 10.3892/ijo.2013.1858
O. Togao, C. W. Kessinger, G. Huang, T. C. Soesbe, K. Sagiyama, I. Dimitrov, D. A. Sherry, J. Gao, *M. Takahashi. Characterization of lung cancer by amide proton transfer (APT) imaging: An in-vivo study in an orthotopic mouse model. PLoS One 8(10):e77019 (2013). doi: 10.1371/journal.pone.0077019. PMID: 24143199
O. Togao, T. Yoshiura, J. Keupp, A. Hiwatashi, K. Yamashita, K. Kikuchi, Y. Suzuki, S. O. Suzuki, T. Iwaki, N. Hata, M. Mizoguchi, K. Yoshimoto, K. Sagiyama, M. Takahashi, H. Honda. Amide proton transfer imaging of diffuse gliomas: Correlation with histopathological grades. Neuro-Oncol 16(3):441-448 (2014). Dec 4. [Epub ahead of print] PMID: 24305718
K. Sagiyama, T. Mashimo, O. Togao, V. Vemireddy, K. J. Hatanpaa, E. Maher, B. E. Mickey, E. Pan, A. D. Sherry, R. Bachoo, M. Takahashi. In vivo chemical exchange saturation transfer (CEST) imaging allows early detection of a therapeutic response in glioblastoma. Proc Natl Acad Sci USA 25;111(12):4542-4547 (2014) doi: 10.1073/pnas.1323855111, PMID: 24616497
K. Sakaie, M. Takahashi, K. Sagiyama, I. Dimitrov, T. Frohman, G. Remington, E. M. Frohman, R. Fox. Clinical/scientific notes: Injury to a specific neural pathway detected by ultra-high-field MRI. Neurology 82:182-183. (2014) PMID: 24285615, PMCID: PMC3897439 [Available on 2015/1/14]
Y Ohno, H. M. Nishino, K. Koyama, D. Takenaka, M. Takahashi, T. Yoshikawa, S. Matsumoto, M. Obara, Van Cauteren, K. Sugimura. Pulmonary MR imaging with ultra-short TEs: Utility for disease severity assessment of connective tissue disease patients. Eur J Radiolo, 82(8): 1359-1369 (2013)
Y. Ohno, M. Nishio, H. Koyama, T. Yoshikawa, S. Matsumoto, S. Seki, M. Obara, M. van Cauteren, M. Takahashi, K. Sugimura K. Pulmonary 3 T MRI with ultrashort TEs: influence of ultrashort echo time interval on pulmonary functional and clinical stage assessments of smokers. J Magn Reson Imaging. 39(4):988-97 (2014). doi: 10.1002/jmri.24232. PMID: 24123342
A. Kumar, S. Zhang, G. Hao, G. Hassan, S. Ramezani, K. Sagiyama, S-T. Lo, M. Takahashi, A. D. Sherry, O. K. Öz, Z. Kovacs, X. Sun. Molecular platform for design and synthesis of targeted dual-modality imaging probes. Bioconjugate Chem. 18; 26(3): 549–558 (2015) doi: 10.1021/acs.bioconjchem.5b00028, PMCID: PMC4428032
M.C. Hu, M. Shi, H.J. Cho, B. Adams-Huet, J. Paek, J. Shleton, A. P. Amaral, C. Faul, M. Taniguchi, M. Wolf, M. Brand, M. Takahashi, M. Kuro-o, J. A. Hill, O.W. Moe. Klotho and phosphate: Modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrology 26(6): 1290–1302 (2015) PMCID: PMC4446876
O. Togao, T. Yoshiura, J. Keupp, A. Hiwatashi, K. Yamashita, K. Kikuchi, Y. Suzuki, M. J. Kruiskamp, K. Sagiyama, M. Takahashi, H. Honda. Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors. JMRI 42(5): 1346-1353 (2015) doi: 10.1002/jmri.24895
O. Togao, A. Hiwatashi, J. Keupp, K. Yamashita, K. Kikuchi, M. Yoneyama, M.J. Kruiskamp, K. Sagiyama, T. Yoshiura, M. Takahashi, H. Honda. Amide proton transfer imaging of diffuse gliomas: Effect of saturation pulse length in parallel transmission-based technique. Plos-One 11(5): e0155925 (2016) PMCID: PMC4881971
P. Ravikumar, J. U. Menon, P. Punnakitikashem, D. Gyawali, O. Togao, M. Takahashi, J. Zhang, J. Ye, O. W. Moe, K. T. Nguyen, C. C. W. Hsia. Nanoparticle facilitated inhalational delivery of erythropoietin receptor cDNA protects against hyperoxic lung injury. Nanomedicine: Nanotechnology, Biology, and Medicine; NBM 12(3):811-21. doi: 10.1016, (2016) PMID:26518603, PMCID:PMC4809756

K. Sakaie, M. Takahashi, G. Remington, X. Wang, A Conger, D Conger, I. Dimitrov, S. Jones, A Frohman, T. Frohman, K. Sagiyama, O. Togao, R. Fox, E. Frohman. Correlating function and imaging measures of the medial longitudinal fasciculus. Pros-One 11(1): e0147863 (2016) PMCID: PMC4723147
T. Kubo, Y. Ohno,D. Takenaka, M. Nishino, S. Gautam, K. Sugimura, H. U. Kauczor, H. Hatabu, P.-J. Lin, M. Takahashi, A. Sitek, M. Nogami, H. Koyama, J. Ley-Zaporozhan, W. Stiller, S. Ley, H. Inokawa, Y. Fujikawa, H. Kura, V. Raptopoulos. Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization-iLEAD study. Euro J Radiol 3:67-73 (2016)
M. C. Hu, M. Shi, J. Zhang, T. Addo, H. J. Cho, S. L. Barker, P. Ravikumar, N. Gillings, A. Bian, S. S. Sidhu, M. Takahashi, M. Kuro-o, O. W. Moe. Renal production, uptake, and handling of circulating αKlotho. J Am Soc Nephrol; 27(1): 79–90 (2016). doi: 10.1681/ASN.2014101030, PMCID:PMC4696570
M. A. Yousuf, C. Tan, M. I. Torres-Altoro, F. –M. Lu, E. Plaitz, S. Zhang, M. Takahashi, A. Hernandez, S. G. Kernie, F. Plattner, J. A. Bibb. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. J Neurochemistry 1; 317-327 (2016)
O. Togao, A. Hiwatashi, K. Yamashita, K. Kikuchi, J. Keupp, K. Yoshimoto, D. Kuga, M. Yoneyama, S. O. Suzuki, T. Iwaki, M. Takahashi, K. Iihara, H. Honda. Grading diffuse gliomas without intense contrast enhancement by amide proton transfer MR imaging: comparisons with diffusion- and perfusion-weighted imaging. Eur Radiol; 27(2): 578-588 (2017) doi: 10.1007/s00330-016-4328-0
M. C. Hu, M. Shi, N. Gillings, B. Flores, M. Takahashi, M. Kuro-o, O. W. Moe. Recombinant α-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy. Kidney Intr 91 (5): 1104-1114 (2017)
B. D. Newton, K. Wright, M. D. Winkler, F. Bovis, M. Takahashi, I. E. Dimitrov, M. Pia Sormani, M. C. Pinho, D. T. Okuda. Three-dimensional shape and surface features contrast multiple sclerosis from Non-Specific white matter disease. J Neuroimaging 27 (6): 613-619 (2017) PMID: 28488804, doi: 10.1111/jon.12449.
R. Z. Hussain, W. A. Miller-Little, D. Lambracht-Washington, T. C. Jaramillo, M. Takahashi, S. Zhang, C. Castro-Rojas, K. Deason, M. Fu, L. Hayardeny, C. M. Powell, R. N. Rosenberg, O. Stüve. Laquinimod has no effects on brain volume or cellular CNS composition in the F1 3xTg-AD/C3H mouse model of Alzheimer's disease. J Neuroimmunol 309: 100–110 (2017)
K. Kikuchi, K. Ishimatsu, S. Zhang, I. E. Dimitrov, H. Honda, A. D. Sherry, *M. Takahashi. Presaturation power adjusted pulsed (PPAP)-CEST: A method to increase independence of target CEST signals. Contrast Media& Molecular Imaging (CMMI) 2018; 1-11 (2018) ID: 3141789 PMCID: PMC5964408, PMID: 29853805, doi: 10.1155/2018/3141789

K. Gong, G. Guo, D. E. Gerber, B. Gao, M. Peyton, C. Huang, J. D. Minna, K. J. Hatanpaa, K. Kernstine, L. Cai, Y. Xie, H. Zhu, F. J. Fattah, S. Zhang, M. Takahashi, B. Mukherjee, S. Burma, J. Dowell, K. Dao, V. A. Papadimitrakopoulou, V. Olivas, T. G. Bivona, M. MA, K. Politi, D. Zhao, A. A. Habib. TNF drives an adaptive response that mediates resistance to EGFR inhibition in lung cancer. Journal of Clinical Investigation: JCI;128(6):2500-2518. (2018) https://doi.org/10.1172/JCI96148

S. K. Park, T. R. Rosenthal, J. S. Williams, J. M. Shelton, M. Takahashi, S. Zhang. I. A. Bobulescu. Metabolic and cardiovascular effects of chronic mild hyperuricemia in rodents. J Invest Med 66;1037-1044 (2018) doi: 10.1136/jim-2018-000729.
Y. Ohno, M. Takahashi, H. Koyama, T. Yoshioka, Challenge of using 3T MR system and whole-body MRI for lung imaging. KAUCZER H-. U., WEILPUTZ M. O. 2nd ed. Switzerland: Springer; 2018: 479-505.
K. Pozo, S. Zahler, K. Ishimatsu, A. M. Carter, R. Telange, C. Tan, S. Wang, R. Pfragner, J. Fujimoto, E. G. Grubbs, M. Takahashi, S. C. Oltmann, J. A. Bibb. Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer. Oncotarget 9 (102): 37662–37675, 2018 Dec 28. doi: 10.18632/oncotarget.26480, PMCID: PMC6340867
N. Pandey, J. U. Menon, M. Takahashi, J. T. Hsieh, J. Yang, K. T. Nguyen, A. S. Wadajkar. Thermo-responsive fluorescent nanoparticles for multimodal imaging and treatment of cancers. Nanotheranostics. 1;4(1):1-13 (2020). doi: 10.7150/ntno.39810. eCollection (2020).
A. M. Carter , C. Tan, K. Pozo, R. Telange, R. Molinaro, A. Guo, E. De Rosa, J. O. Martinez, S. Zhang, N. Kumar, M. Takahashi, T. Wiederhold, H. K. Ghayee, S. C. Oltmann, K. Pacak, E. A. Woltering, K. J. Hatanpaa, F. E. Nwariaku, E. G. Grubbs, A. J. Gill, B. Robinson, F. Gillardon, S. Reddy, R. Jaskula-Sztul1, J. A. Mobley, M. S. Mukhtar, E. Tasciotti, H. Chen, J. A. Bibb. Phosphoprotein-based biomarkers as predictors for cancer therapy. Proc Natl Acad Sci USA 117 (31) 18401-18411 (2020)
M. C. Hu, M. Shi, H. J- Cho, M.Takahashi, M. Mohammadi, and O. W. Moe . C-Terminal fragment of fibroblast growth factor (FGF)-23 improves heart function in murine models of high intact FGF23. AJP-Renal Physiol 326:F584-F599 (2024)
X. Wang, K. Ishimatsu, J. Li, X. Wen, W. Ou, A. Anwar, J. Chaudhary, M. Takahashi, A. Dean Sherry and I. R. Corbin. APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage. Hepatic Oncology, 11:1, 2389031 (2024)
K. Ishimatsu, K. Kikuchi, O. W. Moe, K. Oshio, K. Ishigami, M. Takahashi. Evaluation of renal perfusion: A comparative study between intravoxel incoherent motion (IVIM) imaging and arterial spin labeling (ASL) to assess renal blood flow in rodents. MRMS (online-2024 https://doi.org/10.2463/mrms.mp.2023-0169)
T. Urushihata, M. Takahashi, M. Shimojo, Y. Takado, N. Nitta, Y. Tajima, K. Masamoto,a,, I. Kanno, Y. Tomita,N. Sahara, M. Takahashi, T. Obata, H. Ito, T. Yamashita,T. Suhara, M. Higuchi, H. Takuwa Neuronal deterioration associated with hyperexcitability under mild chronic cerebral hypoperfusion. JCBFM (accepted)

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高橋 昌哉（タカハシ マサヤ）

高橋昌哉（タカハシマサヤ）