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吉川茜（ヨシカワアカネ）

研究テーマ	統合失調症の早期診断法開発
研究業績（論文）	1. Kasai　K, Yoshikawa A, Natsubori T, Koike S, Nagai T, Araki T, Nishimura Y, Iwamoto K: Biological study in schizophrenia. Brain and Nerve = Shinkei Kenkyu no Shinpo, 64: 109-118, 2012 2. Kawamura Y, Takahashi T, Liu X, Nishida N, Noda Y, Yoshikawa A, Umekage T, Sasaki T: Variation in the DRD2 gene affects impulsivity in intertemporal choice. Open Journal of Psychiatry 3: 26-31, 2013 3. Kawamura Y, Takahashi T, Liu X, Nishida N, Tokunaga K, Ukawa K, Noda Y, Yoshikawa A, Shimada T, Umekage T, Sasaki T: DNA polymorphism in the FKBP5 gene affects impulsivity in intertemporal choice. ASIA-PACIFIC PSYCHIATRY 5:31-38, 2013 4. Ikegame T, Bundo M, Sunaga F, Asai T, Nishimura F, Yoshikawa A, Kawamura Y, Hibino H, Tochigi M, Kakiuchi C, Sasaki T, Kato T, Kasai K, Iwamoto K: DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients. Neurosci Res. 77: 208-214, 2013 5. Kawasaki S, Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Yoshikawa A, Inai A, Nishioka M, Eriguchi Y, Kakiuchi C, Araki T, Kan C, Umeda M, Shimazu A, Hashimoto H, Kawakami N, Kasai K: Using social epidemiology and neuroscience to explore the relationship between job stress and frontotemporal cortex activity among workers. Social neuroscience 10: 230-242, 2015 6. Sakakibara E, Homae F, Kawasaki S, Nishimura Y, Takizawa R, Koike S, Kinoshita A, Sakurada H, Yamagishi M, Nishimura F, Yoshikawa A, Inai A, Nishioka M, Eriguchi Y, Matsuoka J, Satomura Y, Okada N, Kakiuchi C, Araki T, Kan C, Umeda M, Shimazu A, Uga M, Dan I, Hashimoto H, Kawakami N, Kasai K: Detection of resting state functional connectivity using partial correlation analysis: A study using multi-distance and whole-head probe near-infrared spectroscopy. NeuroImage 142: 590-601, 2016 7. Li J, Yoshikawa A, Meltzer HY: Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis. Journal of Psychiatric Research 94:54-61, 2017 8. Yoshikawa A, Nishimura F, Inai A, Eriguchi Y, Nishioka M, Takaya A, Tochigi M, Kawamura Y, Umekage T, Kato K, Sasaki T, Ohashi Y, Iwamoto K, Kasai K, Kakiuchi C: Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes. Psychiatry and Clinical Neurosciences 72: 168-179, 2018 9. Yoshikawa A, Nishimura F, Inai A, Eriguchi Y, Nishioka M, Takaya A, Tochigi M, Kawamura Y, Umekage T, Kato K, Sasaki T, Kasai K, Kakiuchi C: Novel rare variations in genes that regulate developmental change in N-methyl-d-aspartate receptor in patients with schizophrenia. Human Genome Variation 5:1-5, 2018 10. Li J, Yoshikawa A, Brennan MD, Ramsey TL, Meltzer HY: Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes. Schizophrenia Research 192:194-204, 2018 11. Sugawara H, Murata Y, Ikegame T, Sawamura R, Shimanaga S, Takeoka Y, Saito T, Ikeda M, Yoshikawa A, Nishimura F, Kawamura Y, Kakiuchi C, Sasaki T, Iwata N, Hashimoto M, Kasai K, Kato T, Bundo M, Iwamoto K: DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder. Psychiatry Clin Neurosci. 72: 245-254, 2018 12. Nishioka M, Bundo M, Ueda J, Yoshikawa A, Nishimura F, Sasaki T, Kakiuchi C, Kasai K, Kato T, Iwamoto K: Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders. NPJ Schizophr. 4: 7, 2018 13. Zhao Z, Jinde S, Koike S, Tada M, Satomura Y, Yoshikawa A, Nishimura Y, Takizawa R, Kinoshita A, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Inai A, Nishioka M, Eriguchi Y, Araki T, Takaya A, Kan C, Umeda M, Shimazu A, Hashimoto H, Bundo M, Iwamoto K, Kakiuchi C, Kasai K: Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia and its possible relation to neuronal migration-related genes. Translational Psychiatry 9: 289. 2019 14. Yoshikawa A, Li J, Meltzer HY: A functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: confirmation with meta-analysis of other antipsychotic drugs. The Pharmacogenomics Journal 20: 260-270, 2020 15. Ikegame T, Bundo M, Okada N, Murata Y, Koike S, Sugawara H, Saito T, Ikeda M, Owada K, Fukunaga M, Yamashita F, Koshiyama D, Natsubori T, Iwashiro N, Asai T, Yoshikawa A, Nishimura F, Kawamura Y, Ishigooka J, Kakiuchi C, Sasaki T, Abe O, Hashimoto R, Iwata N, Yamasue H, Kato T, Kasai K, Iwamoto K: Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia. Schizophrenia bulletin 2020 16. Kobori A, Miyashita M, Miyano Y, Suzuki K, Toriumi K, Niizato K, Oshima K, Imai A, Nagase Y, Yoshikawa A, Horiuchi Y, Yamasaki S, Nishida A, Usami S, Takizawa S, Itokawa M, Arai H, Arai M. Advanced glycation end products and cognitive impairment in schizophrenia. PloS one 16(5) e0251283, 2021 17. Ohnishi T, Kiyama Y, Arima-Yoshida F, Kadota M, Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, Nozaki Y, Kurokawa R, Suzuki K, Yoshikawa A, Toyota T, Hosoya T, Okuno H, Bito H, Itokawa M, Kuraku S, Manabe T, Yoshikawa T. Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. EMBO molecular medicine 13(4) e12574, 2021 18. Toriumi K, Miyashita M, Suzuki K, Yamasaki N, Yasumura M, Horiuchi Y, Yoshikawa A, Asakura M, Usui N, Itokawa M, Arai M. Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment. Translational psychiatry 11(1): 262-262, 2021 19. Yoshikawa A, Kushima I, Miyashita M, Toriumi K, Suzuki K, Horiuchi Y, Kawaji H, Takizawa S, Ozaki N, Itokawa M, Arai M. Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress. Translational psychiatry 11(1) :331-331, 2021 20. Toriumi K, Berto S, Koike S, Usui N, Dan T, Suzuki K, Miyashita M, Horiuchi Y, Yoshikawa A, Asakura M, Nagahama K, Hsiao-Chun Lin, Sugaya Y, Watanabe T, Kano M, Ogasawara Y, Miyata T, Itokawa M, Konopka G, Arai M. Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex. Redox Biology 45:102057-102057, 2021 21. Miyashita M, Yamasaki S, Ando S, Suzuki K, Toriumi K, Horiuchi Y, Yoshikawa A, Imai A, Nagase Y, Miyano Y, Inoue T, Endo K, Morimoto Y, Morita M, Kiyono T, Usami S, Okazaki Y, Toshiaki A. Furukawa A, Hiraiwa-Hasegawa M, Itokawa M, Kasai K, Nishida A, Arai M. Fingertip advanced glycation end products and psychotic symptoms among adolescents. npj Schizophrenia 7(1) 2021 22. Yoshikawa A, Kushima I, Miyashita M, Suzuki K, Iino K, Toriumi K, Horiuchi Y, Kawaji H, Ozaki N, Itokawa M, Arai M. Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype. PloS one 17(7) e0270506 2022 23. Suzuki K, Yamasaki S, Miyashita M, Ando S, Toriumi K, Yoshikawa A, Nakanishi M, Morimoto Y, Kanata S, Fujikawa S, Endo K, Koike S, Usami S, Itokawa M, Washizuka S, Hiraiwa-Hasegawa M, Meltzer HY, Kasai K, Nishida A, Arai M. Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents. Schizophrenia 8(1) 2022 24. Li J, Yoshikawa A, Alliey-Rodriguez N, Meltzer HY. Schizophrenia risk loci from xMHC region were associated with antipsychotic response in chronic schizophrenic patients with persistent positive symptom. Translational psychiatry 12, 1-9, 2022 25. Tomita Y, Suzuki K, Yamasaki S, Toriumi K, Miyashita M, Ando S, Endo K, Yoshikawa A, Tabata K, Usami S, Hiraiwa-Hasegawa M, Itokawa M, Kawaji H, Kasai K, Nishida A & Arai M. Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences. Schizophrenia 9(14) 2023 26. Katsuta N, Takahashi K, Kurosawa Y, Yoshikawa A, Takeshita Y, Uchida Y, Yasuda S, Kakiuchi C, Ito M, Kato T. Safety and real-world efficacy of lemborexant in the treatment of comorbid insomnia. Sleep medicine: X 5 100070-100070 2023 27. Fujimura, T, Yoshikawa A (他13名, 番目), Kato T. Factors associated with self-perceived treatment-resistance in bipolar disorder. Medicine 103(1):e36217, 2024. 28. Yoshikawa A, Obata Y, Kakiuchi C, Nakanishi A, Kimura S, Aoki S, Kato T. Case series of patients with early psychosis presenting hypoperfusion in angular gyrus and self-disturbance - implication for the sense of agency and schizophrenia. Neuropsychopharmacology Reports, 2024,00:1–10. 2024. 29. Yoshikawa A, Li J, Meltzer HY. Genetic markers of early response to lurasidone in acute schizophrenia. The Pharmacogenomics Journal, 25(2): 3. 2025.

研究テーマ

統合失調症の早期診断法開発

研究業績（論文）

1. Kasai　K, Yoshikawa A, Natsubori T, Koike S, Nagai T, Araki T, Nishimura Y, Iwamoto K: Biological study in schizophrenia. Brain and Nerve = Shinkei Kenkyu no Shinpo, 64: 109-118, 2012

2. Kawamura Y, Takahashi T, Liu X, Nishida N, Noda Y, Yoshikawa A, Umekage T, Sasaki T: Variation in the DRD2 gene affects impulsivity in intertemporal choice. Open Journal of Psychiatry 3: 26-31, 2013

3. Kawamura Y, Takahashi T, Liu X, Nishida N, Tokunaga K, Ukawa K, Noda Y, Yoshikawa A, Shimada T, Umekage T, Sasaki T: DNA polymorphism in the FKBP5 gene affects impulsivity in intertemporal choice. ASIA-PACIFIC PSYCHIATRY 5:31-38, 2013

4. Ikegame T, Bundo M, Sunaga F, Asai T, Nishimura F, Yoshikawa A, Kawamura Y, Hibino H, Tochigi M, Kakiuchi C, Sasaki T, Kato T, Kasai K, Iwamoto K: DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients. Neurosci Res. 77: 208-214, 2013

5. Kawasaki S, Nishimura Y, Takizawa R, Koike S, Kinoshita A, Satomura Y, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Yoshikawa A, Inai A, Nishioka M, Eriguchi Y, Kakiuchi C, Araki T, Kan C, Umeda M, Shimazu A, Hashimoto H, Kawakami N, Kasai K: Using social epidemiology and neuroscience to explore the relationship between job stress and frontotemporal cortex activity among workers. Social neuroscience 10: 230-242, 2015

6. Sakakibara E, Homae F, Kawasaki S, Nishimura Y, Takizawa R, Koike S, Kinoshita A, Sakurada H, Yamagishi M, Nishimura F, Yoshikawa A, Inai A, Nishioka M, Eriguchi Y, Matsuoka J, Satomura Y, Okada N, Kakiuchi C, Araki T, Kan C, Umeda M, Shimazu A, Uga M, Dan I, Hashimoto H, Kawakami N, Kasai K: Detection of resting state functional connectivity using partial correlation analysis: A study using multi-distance and whole-head probe near-infrared spectroscopy. NeuroImage 142: 590-601, 2016

7. Li J, Yoshikawa A, Meltzer HY: Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis. Journal of Psychiatric Research 94:54-61, 2017

8. Yoshikawa A, Nishimura F, Inai A, Eriguchi Y, Nishioka M, Takaya A, Tochigi M, Kawamura Y, Umekage T, Kato K, Sasaki T, Ohashi Y, Iwamoto K, Kasai K, Kakiuchi C: Mutations of the glycine cleavage system genes possibly affect the negative symptoms of schizophrenia through metabolomic profile changes. Psychiatry and Clinical Neurosciences 72: 168-179, 2018

9. Yoshikawa A, Nishimura F, Inai A, Eriguchi Y, Nishioka M, Takaya A, Tochigi M, Kawamura Y, Umekage T, Kato K, Sasaki T, Kasai K, Kakiuchi C: Novel rare variations in genes that regulate developmental change in N-methyl-d-aspartate receptor in patients with schizophrenia. Human Genome Variation 5:1-5, 2018

10. Li J, Yoshikawa A, Brennan MD, Ramsey TL, Meltzer HY: Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes. Schizophrenia Research 192:194-204, 2018

11. Sugawara H, Murata Y, Ikegame T, Sawamura R, Shimanaga S, Takeoka Y, Saito T, Ikeda M, Yoshikawa A, Nishimura F, Kawamura Y, Kakiuchi C, Sasaki T, Iwata N, Hashimoto M, Kasai K, Kato T, Bundo M, Iwamoto K: DNA methylation analyses of the candidate genes identified by a methylome-wide association study revealed common epigenetic alterations in schizophrenia and bipolar disorder. Psychiatry Clin Neurosci. 72: 245-254, 2018

12. Nishioka M, Bundo M, Ueda J, Yoshikawa A, Nishimura F, Sasaki T, Kakiuchi C, Kasai K, Kato T, Iwamoto K: Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders. NPJ Schizophr. 4: 7, 2018

13. Zhao Z, Jinde S, Koike S, Tada M, Satomura Y, Yoshikawa A, Nishimura Y, Takizawa R, Kinoshita A, Sakakibara E, Sakurada H, Yamagishi M, Nishimura F, Inai A, Nishioka M, Eriguchi Y, Araki T, Takaya A, Kan C, Umeda M, Shimazu A, Hashimoto H, Bundo M, Iwamoto K, Kakiuchi C, Kasai K: Altered expression of microRNA-223 in the plasma of patients with first-episode schizophrenia and its possible relation to neuronal migration-related genes. Translational Psychiatry 9: 289. 2019

14. Yoshikawa A, Li J, Meltzer HY: A functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: confirmation with meta-analysis of other antipsychotic drugs. The Pharmacogenomics Journal 20: 260-270, 2020

15. Ikegame T, Bundo M, Okada N, Murata Y, Koike S, Sugawara H, Saito T, Ikeda M, Owada K, Fukunaga M, Yamashita F, Koshiyama D, Natsubori T, Iwashiro N, Asai T, Yoshikawa A, Nishimura F, Kawamura Y, Ishigooka J, Kakiuchi C, Sasaki T, Abe O, Hashimoto R, Iwata N, Yamasue H, Kato T, Kasai K, Iwamoto K: Promoter Activity-Based Case-Control Association Study on SLC6A4 Highlighting Hypermethylation and Altered Amygdala Volume in Male Patients With Schizophrenia. Schizophrenia bulletin 2020

16. Kobori A, Miyashita M, Miyano Y, Suzuki K, Toriumi K, Niizato K, Oshima K, Imai A, Nagase Y, Yoshikawa A, Horiuchi Y, Yamasaki S, Nishida A, Usami S, Takizawa S, Itokawa M, Arai H, Arai M. Advanced glycation end products and cognitive impairment in schizophrenia. PloS one 16(5) e0251283, 2021

17. Ohnishi T, Kiyama Y, Arima-Yoshida F, Kadota M, Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, Nozaki Y, Kurokawa R, Suzuki K, Yoshikawa A, Toyota T, Hosoya T, Okuno H, Bito H, Itokawa M, Kuraku S, Manabe T, Yoshikawa T. Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. EMBO molecular medicine 13(4) e12574, 2021

18. Toriumi K, Miyashita M, Suzuki K, Yamasaki N, Yasumura M, Horiuchi Y, Yoshikawa A, Asakura M, Usui N, Itokawa M, Arai M. Vitamin B6 deficiency hyperactivates the noradrenergic system, leading to social deficits and cognitive impairment. Translational psychiatry 11(1): 262-262, 2021

19. Yoshikawa A, Kushima I, Miyashita M, Toriumi K, Suzuki K, Horiuchi Y, Kawaji H, Takizawa S, Ozaki N, Itokawa M, Arai M. Dysregulation of post-transcriptional modification by copy number variable microRNAs in schizophrenia with enhanced glycation stress. Translational psychiatry 11(1) :331-331, 2021

20. Toriumi K, Berto S, Koike S, Usui N, Dan T, Suzuki K, Miyashita M, Horiuchi Y, Yoshikawa A, Asakura M, Nagahama K, Hsiao-Chun Lin, Sugaya Y, Watanabe T, Kano M, Ogasawara Y, Miyata T, Itokawa M, Konopka G, Arai M. Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex. Redox Biology 45:102057-102057, 2021

21. Miyashita M, Yamasaki S, Ando S, Suzuki K, Toriumi K, Horiuchi Y, Yoshikawa A, Imai A, Nagase Y, Miyano Y, Inoue T, Endo K, Morimoto Y, Morita M, Kiyono T, Usami S, Okazaki Y, Toshiaki A. Furukawa A, Hiraiwa-Hasegawa M, Itokawa M, Kasai K, Nishida A, Arai M. Fingertip advanced glycation end products and psychotic symptoms among adolescents. npj Schizophrenia 7(1) 2021

22. Yoshikawa A, Kushima I, Miyashita M, Suzuki K, Iino K, Toriumi K, Horiuchi Y, Kawaji H, Ozaki N, Itokawa M, Arai M. Exonic deletions in IMMP2L in schizophrenia with enhanced glycation stress subtype. PloS one 17(7) e0270506 2022

23. Suzuki K, Yamasaki S, Miyashita M, Ando S, Toriumi K, Yoshikawa A, Nakanishi M, Morimoto Y, Kanata S, Fujikawa S, Endo K, Koike S, Usami S, Itokawa M, Washizuka S, Hiraiwa-Hasegawa M, Meltzer HY, Kasai K, Nishida A, Arai M. Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents. Schizophrenia 8(1) 2022

24. Li J, Yoshikawa A, Alliey-Rodriguez N, Meltzer HY. Schizophrenia risk loci from xMHC region were associated with antipsychotic response in chronic schizophrenic patients with persistent positive symptom. Translational psychiatry 12, 1-9, 2022

25. Tomita Y, Suzuki K, Yamasaki S, Toriumi K, Miyashita M, Ando S, Endo K, Yoshikawa A, Tabata K, Usami S, Hiraiwa-Hasegawa M, Itokawa M, Kawaji H, Kasai K, Nishida A & Arai M. Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences. Schizophrenia 9(14) 2023

26. Katsuta N, Takahashi K, Kurosawa Y, Yoshikawa A, Takeshita Y, Uchida Y, Yasuda S, Kakiuchi C, Ito M, Kato T. Safety and real-world efficacy of lemborexant in the treatment of comorbid insomnia. Sleep medicine: X 5 100070-100070 2023

27. Fujimura, T, Yoshikawa A (他13名, 番目), Kato T. Factors associated with self-perceived treatment-resistance in bipolar disorder. Medicine 103(1):e36217, 2024.

28. Yoshikawa A*, Obata Y, Kakiuchi C, Nakanishi A, Kimura S, Aoki S, Kato T. Case series of patients with early psychosis presenting hypoperfusion in angular gyrus and self-disturbance - implication for the sense of agency and schizophrenia. Neuropsychopharmacology Reports, 2024,00:1–10. 2024.

29. Yoshikawa A*, Li J, Meltzer HY. Genetic markers of early response to lurasidone in acute schizophrenia. The Pharmacogenomics Journal, 25(2): 3. 2025.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

吉川 茜（ヨシカワ アカネ）

吉川茜（ヨシカワアカネ）