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貝谷綾子（カイタニアヤコ）

研究テーマ	アレルギー・炎症性疾患の制御機構
研究業績（論文）	■原著論文（英文） 1. Oishi K, Nakano N, Ota M, Inage E, Izawa K, Kaitani A, Ando T, Hara M, Ohtsuka Y, Nishiyama C, Ogawa H, Kitaura J, Okumura K, Shimizu T: MHC class II-expressing mucosal mast cells promote intestinal mast cell hyperplasia in a mouse model of food allergy. Allergy. In press, 2025. 2. Nagamine M, Kaitani A, Izawa K, Ando T, Yoshikawa A, Nakamura M, Maehara A, Yamamoto R, Okamoto Y, Wang H, Yamada H, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability. Front Immunol. 15: 1477072, 2024. 3. Ide T, Izawa K, Diono W, Kamei A, Ando T, Kaitani A, Maehara A, Yoshikawa A, Yamamoto R, Uchida S, Wang H, Kojima M, Maeda K, Nakano N, Nakamura M, Shimizu T, Ogawa H, Okumura K, Matsumoto F, Ikeda K, Goto M, Kitaura J: Intranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models. Sci Rep. 14: 8398, 2024. 4. Kimura M, Ando T, Kume Y, Fukase S, Matsuzawa M, Kashiwagi K, Izawa K, Kaitani A, Nakano N, Maeda K, Ogawa H, Okumura K, Nakao S, Murakami A, Ebihara N, Kitaura J: A nerve-goblet cell association promotes allergic conjunctivitis through the rapid antigen passage. JCI Insight. 8: e168596, 2023. 5. Yamamoto R, Izawa K, Ando T, Kaitani A, Tanabe A, Yamada H, Uchida S, Yoshikawa A, Kume Y, Toriumi S, Maehara A, Wang H, Nagamine M, Negishi N, Nakano N, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy. Front Immunol. 14: 1238297, 2023. 6. Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, Maehara A, Kojima M, Yamamoto R, Wang H, Nagamine M, Maeda K, Uchida K, Nakano N, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Kitaura J: Staphylococcus aureus d-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 14: 1173069, 2023. 7. Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J: The protective role of conjunctival goblet cell mucin sialylation. Nat Commun. 14: 1417, 2023. 8. Kamei A, Izawa K, Ando T, Kaitani A, Yamamoto R, Maehara A, Ide T, Yamada H, Kojima M, Wang H, Tokushige K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper. Front Immunol. 13: 945222, 2022. 9. Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K: Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling. J Immunol. 207: 3098-3106, 2021. 10. Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J: Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice. Ocul Surf. 22: 153-162, 2021. 11. Yasudo H, Ando T, Maehara A, Ando T, Izawa K, Tanabe A, Kaitani A, Nomura S, Seki M, Yoshida K, Oda H, Okamoto Y, Wang H, Kamei A, Kojima M, Kimura M, Uchida K, Nakano N, Kaneko J, Ebihara N, Hasegawa K, Shimizu T, Takita J, Ogawa H, Okumura K, Ogawa S, Tamura N, Kitaura J: A Possible Association Between a Nucleotide-Binding Domain LRR-Containing Protein Family PYD-Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis. Hepatology. 74: 2296-2299, 2021. 12. Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14: 640-651, 2021. 13. Yoneyama T, Nakano N, Hara M, Yamada H, Izawa K, Uchida K, Kaitani A, Ando T, Kitaura J, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J Allergy Clin Immunol. 147: 1063-1076, 2021. 14. Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J: CD300f is a potential therapeutic target for the treatment of food allergy. Allergy. 75: 471-474, 2020. 15. Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J: Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain. J Invest Dermatol. 140: 710-713, 2020. 16. Takahashi M, Izawa K, Urai M, Yamanishi Y, Maehara A, Isobe M, Matsukawa T, Kaitani A, Takamori A, Uchida S, Yamada H, Nagamine M, Ando T, Shimizu T, Ogawa H, Okumura K, Kinjo Y, Kitamura T, Kitaura J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12: 564, 2019. 17. Takamori A, Izawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation. J Allergy Clin Immunol. 143: 1231-1235, 2019. 18. Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J. The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Scientific reports 8(1) 14237-14237 2018 19. Kaitani A, Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8: 8259, 2018. 20. Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805, 2018. 21. Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J Invest Dermatol. 138:1221-1224, 2018. 22. Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 7:4298, 2017. 23. Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J: Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 292: 2924-2932, 2017. 24. Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J: Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65: 777-87, 2016. 25. Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. J Allergy Clin Immunol. 133: 270-273, 2014. 26. Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J. Human CD300C Delivers an Fc Receptor-γ-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition. J Biol Chem. 288: 7662-7675, 2013. 27. Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J: The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37: 827-839, 2012. 28. Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J: A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis. J Immunol. 189, 1773-1779, 2012. 29. Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takamatsu R, Kajikawa M, Takai T, Kitamura T, Kitaura J: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem. 285: 35274-35283, 2010. 30. Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207: 1501-1511, 2010. 31. Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol. 183: 925-936, 2009. ■総説など（和文） 1. 北浦次郎、山田啓迪、貝谷綾子、山本里彩、安藤智暁、伊沢久未：（特集/アレルギーマーチと自然免疫）アレルギーマーチとマスト細胞、アレルギーの臨床。44：9－14、2024。 2. 貝谷綾子、伊沢久未、井出拓磨、前原明絵、安藤智暁、北浦次郎: FcεRIの制御機構（解説）、臨床免疫・アレルギー科。79：300－306、2023。 3. 北浦次郎、伊沢久未、貝谷綾子：＜アレルギー研究の展望＞ペア型免疫受容体とアレルギー疾患、アレルギーの臨床。42：15-19、2022。 4. 伊沢久未、貝谷綾子、北浦次郎：アレルギー疾患と抑制化受容体(特集:抑制化受容体と免疫応答)、炎症と免疫。29：13-18、2021。 5. 貝谷綾子、伊沢久未、内田志野、亀井杏菜、前原明絵、安藤智暁、北浦次郎: CD300f分子とアレルギー（解説）、臨床免疫・アレルギー科。75：218-225、2021。 6. 内田志野、伊沢久未、安藤智暁、貝谷綾子、北浦次郎：CD300は食物アレルギーの治療標的となりうる。臨床免疫・アレルギー科。74：398-405、2020。 7. 貝谷綾子、高森絢子、安藤智暁、伊沢久未、北浦次郎：薬剤による偽アレルギーにおけるCD300fの役割について。臨床免疫・アレルギー科。72：122-128、2019。 8. 貝谷綾子、前原明絵、高森綾子、伊沢久未、北浦次郎：セラミドと皮膚アレルギー・炎症。臨床免疫・アレルギー科。69：576-582、2018。 9. 伊沢久未、前原明絵、貝谷綾子、高森綾子、北浦次郎：敗血症性腹膜炎におけるCD300fとセラミドの役割。臨床免疫・アレルギー科。69：250-256、2018。 10. 伊沢久未、貝谷綾子、前原明絵、北浦次郎：マスト細胞およびIgE依存性のアナフィラキシーを制御する受容体について。臨床免疫・アレルギー科。66：571-575、2016。

研究テーマ

アレルギー・炎症性疾患の制御機構

研究業績（論文）

■原著論文（英文）

1. Oishi K, Nakano N, Ota M, Inage E, Izawa K, Kaitani A, Ando T, Hara M, Ohtsuka Y, Nishiyama C, Ogawa H, Kitaura J, Okumura K, Shimizu T: MHC class II-expressing mucosal mast cells promote intestinal mast cell hyperplasia in a mouse model of food allergy. Allergy. In press, 2025.

2. Nagamine M, Kaitani A, Izawa K, Ando T, Yoshikawa A, Nakamura M, Maehara A, Yamamoto R, Okamoto Y, Wang H, Yamada H, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability. Front Immunol. 15: 1477072, 2024.

3. Ide T, Izawa K, Diono W, Kamei A, Ando T, Kaitani A, Maehara A, Yoshikawa A, Yamamoto R, Uchida S, Wang H, Kojima M, Maeda K, Nakano N, Nakamura M, Shimizu T, Ogawa H, Okumura K, Matsumoto F, Ikeda K, Goto M, Kitaura J: Intranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models. Sci Rep. 14: 8398, 2024.

4. Kimura M, Ando T, Kume Y, Fukase S, Matsuzawa M, Kashiwagi K, Izawa K, Kaitani A, Nakano N, Maeda K, Ogawa H, Okumura K, Nakao S, Murakami A, Ebihara N, Kitaura J: A nerve-goblet cell association promotes allergic conjunctivitis through the rapid antigen passage. JCI Insight. 8: e168596, 2023.

5. Yamamoto R, Izawa K, Ando T, Kaitani A, Tanabe A, Yamada H, Uchida S, Yoshikawa A, Kume Y, Toriumi S, Maehara A, Wang H, Nagamine M, Negishi N, Nakano N, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy. Front Immunol. 14: 1238297, 2023.

6. Yamada H, Kaitani A, Izawa K, Ando T, Kamei A, Uchida S, Maehara A, Kojima M, Yamamoto R, Wang H, Nagamine M, Maeda K, Uchida K, Nakano N, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, Kitaura J: Staphylococcus aureus d-toxin present on skin promotes the development of food allergy in a murine model. Front Immunol. 14: 1173069, 2023.

7. Matsuzawa M, Ando T, Fukase S, Kimura M, Kume Y, Ide T, Izawa K, Kaitani A, Hara M, Nakamura E, Kamei A, Matsuda A, Nakano N, Maeda K, Tada N, Ogawa H, Okumura K, Murakami A, Ebihara N, Kitaura J: The protective role of conjunctival goblet cell mucin sialylation. Nat Commun. 14: 1417, 2023.

8. Kamei A, Izawa K, Ando T, Kaitani A, Yamamoto R, Maehara A, Ide T, Yamada H, Kojima M, Wang H, Tokushige K, Nakano N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Development of mouse model for oral allergy syndrome to identify IgE cross-reactive pollen and food allergens: ragweed pollen cross-reacts with fennel and black pepper. Front Immunol. 13: 945222, 2022.

9. Nakano N, Saida K, Hara M, Izawa K, Ando T, Kaitani A, Kasakura K, Yashiro T, Nishiyama C, Ogawa H, Kitaura J, Okumura K: Mucosal Mast Cell-Specific Gene Expression Is Promoted by Interdependent Action of Notch and TGF-β Signaling. J Immunol. 207: 3098-3106, 2021.

10. Fukase S, Ando T, Matsuzawa M, Kimura M, Sone Y, Izawa K, Kaitani A, Kamei A, Kojima M, Nakano N, Maeda K, Shimizu T, Ogawa H, Okumura K, Nishiyama N, Murakami A, Ebihara N, Kitaura J: Pollen shells and soluble factors play non-redundant roles in the development of allergic conjunctivitis in mice. Ocul Surf. 22: 153-162, 2021.

11. Yasudo H, Ando T, Maehara A, Ando T, Izawa K, Tanabe A, Kaitani A, Nomura S, Seki M, Yoshida K, Oda H, Okamoto Y, Wang H, Kamei A, Kojima M, Kimura M, Uchida K, Nakano N, Kaneko J, Ebihara N, Hasegawa K, Shimizu T, Takita J, Ogawa H, Okumura K, Ogawa S, Tamura N, Kitaura J: A Possible Association Between a Nucleotide-Binding Domain LRR-Containing Protein Family PYD-Containing Protein 1 Mutation and an Autoinflammatory Disease Involving Liver Cirrhosis. Hepatology. 74: 2296-2299, 2021.

12. Takasato Y, Kurashima Y, Kiuchi M, Hirahara K, Murasaki S, Arai F, Izawa K, Kaitani A, Shimada k, Saito Y, Toyoshima S, Nakamura M, Fujisawa K, Okayama Y, Kunisawa J, Kubo M, Takemura N, Uematsu S, Akira S, Kitaura J, Takahashi T, Nakayama T, Kiyono H: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14: 640-651, 2021.

13. Yoneyama T, Nakano N, Hara M, Yamada H, Izawa K, Uchida K, Kaitani A, Ando T, Kitaura J, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T: Notch signaling contributes to the establishment of sustained unresponsiveness to food allergens by oral immunotherapy. J Allergy Clin Immunol. 147: 1063-1076, 2021.

14. Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J: CD300f is a potential therapeutic target for the treatment of food allergy. Allergy. 75: 471-474, 2020.

15. Izawa K, Kaitani A, Ando T, Maehara A, Nagamine M, Yamada H, Ando T, Ide T, Matsuzawa M, Okamoto Y, Yin E, Fukase S, Wang H, Kamei A, Uchida S, Maeda K, Nakano N, Uchida K, Tamura N, Ikeda K, Ebihara N, Shimizu T, Voehringer D, Roers A, Ogawa H, Okumura K, Kitaura J: Differential lipid recognition by mouse versus human CD300f, inhibiting passive cutaneous anaphylaxis, depends on a single amino acid substitution in its immunoglobulin-like domain. J Invest Dermatol. 140: 710-713, 2020.

16. Takahashi M, Izawa K, Urai M, Yamanishi Y, Maehara A, Isobe M, Matsukawa T, Kaitani A, Takamori A, Uchida S, Yamada H, Nagamine M, Ando T, Shimizu T, Ogawa H, Okumura K, Kinjo Y, Kitamura T, Kitaura J: The phytosphingosine-CD300b interaction promotes zymosan-induced, nitric oxide-dependent neutrophil recruitment. Sci Signal. 12: 564, 2019.

17. Takamori A, Izawa K, Kaitani A, Ando T, Okamoto Y, Maehara A, Tanabe A, Nagamine M, Yamada H, Uchida S, Uchida K, Isobe M, Hatayama T, Watanabe D, Ando T, Ide T, Matsuzawa M, Maeda K, Nakano N, Tamura N, Ikeda K, Ebihara N, Shimizu T, Ogawa H, Okumura K, Kitaura J: Identification of inhibitory mechanisms in pseudo-allergy involving Mrgprb2/MRGPRX2-mediated mast cell activation. J Allergy Clin Immunol. 143: 1231-1235, 2019.

18. Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J. The Fab fragment of anti-IgE Cε2 domain prevents allergic reactions through interacting with IgE-FcεRIα complex on rat mast cells. Scientific reports 8(1) 14237-14237 2018

19. Kaitani A, Izawa K, Maehara A, Isobe M, Takamori A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Yamada H, Nagamine M, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Shimizu T, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Leukocyte mono-immunoglobulin-like receptor 8 (LMIR8)/CLM-6 is an FcRγ-coupled receptor selectively expressed in mouse tissue plasmacytoid dendritic cells. Sci Rep. 8: 8259, 2018.

20. Isobe M, Izawa K, Sugiuchi M, Sakanishi T, Kaitani A, Takamori A, Maehara A, Matsukawa T, Takahashi M, Yamanishi Y, Oki T, Uchida S, Uchida K, Ando T, Maeda K, Nakano N, Yagita H, Takai T, Ogawa H, Okumura K, Kitamura T, Kitaura J: The CD300e molecule in mice is an immune-activating receptor. J Biol Chem. 293:3793-3805, 2018.

21. Maehara A, Kaitani A, Izawa K, Shiba E, Nagamine M, Takamori A, Isobe M, Uchida S, Uchida K, Ando T, Keiko M, Nakano N, Voehringer D, Roers A, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Role of the ceramide-CD300f interaction in gram-negative bacterial skin infections. J Invest Dermatol. 138:1221-1224, 2018.

22. Izawa K, Maehara A, Isobe M, Yasuda Y, Urai M, Hoshino Y, Ueno K, Matsukawa T, Takahashi M, Kaitani A, Shiba E, Takamori A, Uchida S, Uchida K, Maeda K, Nakano N, Yamanishi Y, Oki T, Voehringer D, Roers A, Nakae S, Ishikawa J, Kinjo Y, Shimizu T, Ogawa H, Okumura K, Kitamura T, Kitaura J: Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment. Sci Rep. 7:4298, 2017.

23. Shiba E, Izawa K, Kaitani A, Isobe M, Maehara A, Uchida K, Maeda K, Nakano N, Ogawa H, Okumura K, Kitamura T, Shimizu T, Kitaura J: Ceramide-CD300f Binding Inhibits Lipopolysaccharide-induced Skin Inflammation. J Biol Chem. 292: 2924-2932, 2017.

24. Matsukawa T, Izawa K, Isobe M, Takahashi M, Maehara A, Yamanishi Y, Kaitani A, Okumura K, Teshima T, Kitamura T, Kitaura J: Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation. Gut. 65: 777-87, 2016.

25. Izawa K, Isobe M, Matsukawa T, Ito S, Maehara A, Takahashi M, Yamanishi Y, Kaitani A, Oki T, Okumura K, Kitamura T, Kitaura J: Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation. J Allergy Clin Immunol. 133: 270-273, 2014.

26. Takahashi M, Izawa K, Kashiwakura J, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J. Human CD300C Delivers an Fc Receptor-γ-dependent Activating Signal in Mast Cells and Monocytes and Differs from CD300A in Ligand Recognition. J Biol Chem. 288: 7662-7675, 2013.

27. Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, Okumura K, Kitamura T, Kitaura J: The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. Immunity. 37: 827-839, 2012.

28. Yamanishi Y, Takahashi M, Izawa K, Isobe M, Ito S, Tsuchiya A, Maehara A, Kaitani A, Uchida T, Togami K, Enomoto Y, Nakahara F, Oki T, Kajikawa M, Kurihara H, Kitamura T, Kitaura J: A Soluble Form of LMIR5/CD300b Amplifies Lipopolysaccharide-Induced Lethal Inflammation in Sepsis. J Immunol. 189, 1773-1779, 2012.

29. Enomoto Y, Yamanishi Y, Izawa K, Kaitani A, Takamatsu R, Kajikawa M, Takai T, Kitamura T, Kitaura J: Characterization of leukocyte mono-immunoglobulin-like receptor 7 (LMIR7)/CLM-3 as an activating receptor: its similarities to and differences from LMIR4/CLM-5. J Biol Chem. 285: 35274-35283, 2010.

30. Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207: 1501-1511, 2010.

31. Izawa K, Kitaura J, Yamanishi Y, Matsuoka T, Kaitani A, Sugiuchi M, Takahashi M, Maehara A, Enomoto Y, Oki T, Takai T, Kitamura T: An activating and inhibitory signal from an inhibitory receptor LMIR3/CLM-1: LMIR3 augments lipopolysaccharide response through association with FcRgamma in mast cells. J Immunol. 183: 925-936, 2009.

■総説など（和文）

1. 北浦次郎、山田啓迪、貝谷綾子、山本里彩、安藤智暁、伊沢久未：（特集/アレルギーマーチと自然免疫）アレルギーマーチとマスト細胞、アレルギーの臨床。44：9－14、2024。

2. 貝谷綾子、伊沢久未、井出拓磨、前原明絵、安藤智暁、北浦次郎: FcεRIの制御機構（解説）、臨床免疫・アレルギー科。79：300－306、2023。

3. 北浦次郎、伊沢久未、貝谷綾子：＜アレルギー研究の展望＞ペア型免疫受容体とアレルギー疾患、アレルギーの臨床。42：15-19、2022。

4. 伊沢久未、貝谷綾子、北浦次郎：アレルギー疾患と抑制化受容体(特集:抑制化受容体と免疫応答)、炎症と免疫。29：13-18、2021。

5. 貝谷綾子、伊沢久未、内田志野、亀井杏菜、前原明絵、安藤智暁、北浦次郎: CD300f分子とアレルギー（解説）、臨床免疫・アレルギー科。75：218-225、2021。

6. 内田志野、伊沢久未、安藤智暁、貝谷綾子、北浦次郎：CD300は食物アレルギーの治療標的となりうる。臨床免疫・アレルギー科。74：398-405、2020。

7. 貝谷綾子、高森絢子、安藤智暁、伊沢久未、北浦次郎：薬剤による偽アレルギーにおけるCD300fの役割について。臨床免疫・アレルギー科。72：122-128、2019。

8. 貝谷綾子、前原明絵、高森綾子、伊沢久未、北浦次郎：セラミドと皮膚アレルギー・炎症。臨床免疫・アレルギー科。69：576-582、2018。

9. 伊沢久未、前原明絵、貝谷綾子、高森綾子、北浦次郎：敗血症性腹膜炎におけるCD300fとセラミドの役割。臨床免疫・アレルギー科。69：250-256、2018。

10. 伊沢久未、貝谷綾子、前原明絵、北浦次郎：マスト細胞およびIgE依存性のアナフィラキシーを制御する受容体について。臨床免疫・アレルギー科。66：571-575、2016。

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貝谷 綾子（カイタニ アヤコ）

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