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研究業績詳細

鍵山暢之（カギヤマノブユキ）

研究テーマ	循環器内科学、デジタルヘルス、人工知能
研究業績（論文）	1. Yoshikawa M, Otsuki H, Kawamoto T, Shibahashi E, Inagaki Y, Saito-Koyanagi C, Kogure T, Yamaguchi J, Yamamoto M, Kubo S, et al. Prognostic impact of regurgitant volume to left atrial volume ratio on ventricular functional mitral regurgitation. Eur Heart J Cardiovasc Imaging. 2026;27:174-184. doi: 10.1093/ehjci/jeaf304 2. Yamada Y, Konishi M, Kagiyama N, Kasai T, Kamiya K, Saito H, Maekawa E, Kitai T, Iwata K, Jujo K, et al. Prognostic impact of residual symptoms under low and normal physical performance in older patients hospitalized for worsening heart failure. Arch Gerontol Geriatr. 2026;147:106253. doi: 10.1016/j.archger.2026.106253 3. Yamada K, Kagiyama N, Morisawa T, Saitoh M, Iwata K, Kato M, Sakurada K, Kono Y, Iida Y, Taya M, et al. Machine learning prediction of 1-year mortality in older patients with heart failure: a nationwide, multicenter, prospective cohort study. Lancet Reg Health West Pac. 2026;67:101808. doi: 10.1016/j.lanwpc.2026.101808 4. Watanabe Y, Kubota Y, Murata H, Uchiyama S, Asai K, Nasu T, Ishii S, Kagiyama N, Kida K, Fujimoto W, et al. Relevant Adverse Events and Drug Discontinuation of Sacubitril/Valsartan in Patients with Transthyretin Amyloid Cardiomyopathy - Insights from the REVIEW-HF Registry. Int Heart J. 2026;67:221-227. doi: 10.1536/ihj.25-686 5. Unger A, Mandoli GE, Neglia D, Romero Dorta E, Kagiyama N, Borodzicz-Jazdzyk S, Velegraki E, Coisne A, Uygur B, Afana A, et al. Rational and design of EACVI-MMVD study: an international registry on multimodality imaging for mixed and multiple valvular heart disease. Eur Heart J Imaging Methods Pract. 2026;4:qyaf156. doi: 10.1093/ehjimp/qyaf156 6. Uchida S, Kamiya K, Yamashita M, Noda T, Kagiyama N, Matsue Y. Current findings and challenges on frailty, sarcopenia, and cachexia in older patients with heart failure: insights from the FRAGILE-HF study. J Cardiol. 2026;87:10-16. doi: 10.1016/j.jjcc.2025.05.013 7. Tokodi M, Kagiyama N, Pandey A, Nakamura Y, Akama Y, Takamatsu S, Toki M, Kitai T, Okada T, Lam CSP, et al. Comparison of the Expert Guidelines With Artificial Intelligence-Driven Echocardiographic Assessment of Diastolic Function. medRxiv. 2026. doi: 10.64898/2026.04.23.26350072 8. Tanaka H, Fukuda Y, Yamada H, Miyazaki S, Sakamoto J, Daimon M. Practical guidance for echocardiography for cancer therapy-related cardiac dysfunction: 2026 focused update. J Echocardiogr. 2026;24:123-140. doi: 10.1007/s12574-026-00731-4 9. Shimizu M, Takigahira T, Kagiyama N, Kaneko T, Sakamoto A, Fujita W, Yokotsuka N, Miyazaki S, Minamino T, Kato N. Calcific mitral stenosis with mild to moderate transmitral gradients compared with rheumatic mitral stenosis. Eur Heart J Cardiovasc Imaging. 2026;27:1252-1254. doi: 10.1093/ehjci/jeag085 10. Sato E, Kaneko T, Kagiyama N, Fujita W, Nishio R, Takahashi N, Doi S, Miyazaki S, Iwata H, Okazaki S, et al. How to guide transcatheter aortic valve implantation using intracardiac echocardiography. Eur Heart J Cardiovasc Imaging. 2026;27:289-292. doi: 10.1093/ehjci/jeaf253 11. Sato E, Kagiyama N, Kasai T, Morito K, Nakajima Y, Ito Y, Dotare T, Sunayama T, Kaneko T, Sato A, et al. Video-Based Automatic Quantification of Leg Edema: a Pilot Study in Patients With Hemodialysis With and Without Heart Failure　- Proof-of-Concept Study. Circ Rep. 2026;8:162-164. doi: 10.1253/circrep.CR-25-0180 12. Sakamoto A, Kagiyama N, Sato E, Nakamura Y, Murata A, Kaneko T, Miyazaki S, Ashikawa Y, Sugihara K, Minamino T. Artificial Intelligence-Based Automated Echocardiographic Analysis and the Workflow of Sonographers: A Randomized Crossover Trial (AI-Echo RCT). J Am Heart Assoc. 2026;15:e045637. doi: 10.1161/jaha.125.045637 13. Saito Y, Nagashima K, Kitano D, Miyauchi K, Nishizaki Y, Miyazaki S, Hayashi H, Nojiri S, Kagiyama N, Daida H, et al. Clinical utility of the BREATH score for heart failure risk stratification in patients with atrial fibrillation. J Cardiol. 2026. doi: 10.1016/j.jjcc.2026.03.012 14. Nakamura Y, Kagiyama N, Shrestha S, Akama Y, Kito S, Takamatsu S, Toki M, Kitai T, Okada T, Murata A, et al. Explainable machine learning for estimation of elevated left ventricular filling pressure: a multicenter validation. J Echocardiogr. 2026. doi: 10.1007/s12574-026-00738-x 15. Nakade T, Maeda D, Matsue Y, Kagiyama N, Ikeda Y, Saito K, Kamiya K, Saito H, Toki M, Maekawa E, et al. Prognostic Impact of Respiratory Sarcopenia in Older Patients with Heart Failure: A Post-hoc Analysis from the SONIC-HF Registry. Eur J Prev Cardiol. 2026. doi: 10.1093/eurjpc/zwag008 16. Nakade T, Maeda D, Matsue Y, Kagiyama N, Fujimoto Y, Ikeda Y, Sunayama T, Taishi D, Jujo K, Saito K, et al. Comparative prognostic value of three frailty-assessment tools in older patients with heart failure: post hoc analysis of the FRAGILE-HF cohort. Age Ageing. 2026;55. doi: 10.1093/ageing/afag031 17. Matsuo K, Kamiya K, Maeda D, Hamazaki N, Uchida S, Yamashita M, Konishi M, Kasai T, Saito H, Saito K, et al. C-reactive protein-to-albumin ratio as a marker of frailty, impaired physical function, and mortality in older adults with heart failure. Nutr Metab Cardiovasc Dis. 2026;36:104377. doi: 10.1016/j.numecd.2025.104377 18. Matsuo K, Kamiya K, Maeda D, Hamazaki N, Uchida S, Yamashita M, Konishi M, Kasai T, Saito H, Ogasahara Y, et al. Six-item screener for cognitive and prognostic assessment in heart failure: A comparison with the mini-cog. J Cardiol. 2026;87:275-281. doi: 10.1016/j.jjcc.2025.11.009 19. Matsuo K, Kamiya K, Maeda D, Hamazaki N, Uchida S, Yamashita M, Konishi M, Kasai T, Saito H, Ogasahara Y, et al. Association of Muscle-specific Strength With Impaired Physical Function and Prognosis in Heart Failure: A Comparison With Muscle Strength. J Am Med Dir Assoc. 2026;27:106151. doi: 10.1016/j.jamda.2026.106151 20. Matsuo K, Kamiya K, Maeda D, Hamazaki N, Uchida S, Yamashita M, Konishi M, Kasai T, Saito H, Ogasahara Y, et al. Prognostic value of GLIM criteria with and without inflammation assessment in older patients with heart failure: FRAGILE-HF cohort. Clin Nutr ESPEN. 2026;73:103127. doi: 10.1016/j.clnesp.2026.103127 21. Matsuo K, Kamiya K, Maeda D, Hamazaki N, Uchida S, Yamashita M, Konishi M, Kasai T, Saito H, Ogasahara Y, et al. Combined GLIM-defined malnutrition and sarcopenia and the risk of 2-year mortality in adults with heart failure: A FRAGILE-HF study post hoc analysis. JPEN J Parenter Enteral Nutr. 2026. doi: 10.1002/jpen.70110 22. Matsumoto S, Nasu T, Fujimoto W, Kagiyama N, Shiraishi Y, Ishii S, Ijichi T, Nakazawa G, Ikeda T, Kanaoka K. Vericiguat and hypotension in patients with heart failure and reduced ejection fraction: VERIFY-HF registry. Am Heart J. 2026;292:107281. doi: 10.1016/j.ahj.2025.09.013 23. Kato N, Watanabe T, Ishihara T, Kagiyama N, Shimizu M, Abe Y, Matsumura Y, Onishi T, Ichikawa Y, Nakanishi K, et al. Mitral Annular Calcification-Related Mitral Stenosis: 5-Year Outcomes and Prognostic Determinants in the JAMAC Study. J Am Coll Cardiol. 2026. doi: 10.1016/j.jacc.2025.12.004 24. Kato N, Ito J, Kaneko T, Hirose N, Amano M, Okada T, Sato Y, Ohno Y, Obokata M, Sato K, et al. Clinical Significance of Extreme Left Atrial Enlargement in Atrial Functional Mitral Regurgitation. Am J Cardiol. 2026;270:60-66. doi: 10.1016/j.amjcard.2026.03.067 25. Kanenawa K, Ando K, Nasu T, Fujimoto W, Kagiyama N, Shiraishi Y, Ishii S, Ijichi T, Nakazawa G, Kanaoka K, et al. Changes in Natriuretic Peptide Levels and Cardiac Structure in Patients Treated With Vericiguat　- VERIFY-HF Registry. Circ J. 2026;90:628-638. doi: 10.1253/circj.CJ-25-1087 26. Kaneko T, Kagiyama N, Okazaki S, Amano M, Sato Y, Ohno Y, Obokata M, Sato K, Morita K, Kubo S, et al. Transcatheter edge-to-edge repair vs medical therapy in atrial functional mitral regurgitation: a propensity score-based comparison from the OCEAN-Mitral and REVEAL-AFMR registries. Eur Heart J. 2026;47:1304-1314. doi: 10.1093/eurheartj/ehaf511 27. Kanaoka K, Nakoji T, Takegawa K, Ishihara S, Nasu T, Fujimoto W, Kagiyama N, Shiraishi Y, Ishii S, Ijichi T, et al. Guideline-directed medical therapy and hypotension after initiation of vericiguat: Insights from the VERIFY-HF study. J Cardiol. 2026. doi: 10.1016/j.jjcc.2026.03.006 28. Kagiyama N, Tokodi M, Hathaway QA, Arnaout R, Davies R, Dey D, Duchateau N, Fraser AG, Goto S, Jamthikar AD, et al. PRIME 2.0: Proposed Requirements for Cardiovascular Imaging-Related Multimodal-AI Evaluation: An Updated Checklist. JACC Cardiovasc Imaging. 2026;19:225-251. doi: 10.1016/j.jcmg.2025.08.004 29. Akama Y, Nakade T, Matsue Y, Kagiyama N, Nakamura Y, Fujimoto Y, Maeda D, Inoue H, Sunayama T, Dotare T, et al. Prognostic Value of Handgrip Strength in Older Patients With Heart Failure: A Post Hoc Analysis of FRAGILE-HF. J Am Heart Assoc. 2026;15:e042280. doi: 10.1161/jaha.125.042280 30. Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, et al. Correction to: BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation. 2025;151:e967. doi: 10.1161/cir.0000000000001337 31. Watanabe Y, Kubota Y, Nishino T, Nasu T, Ishii S, Kagiyama N, Kida K, Fujimoto W, Kanaoka K, Matsumoto S. Temporal Changes in HbA1c Levels after Sacubitril/Valsartan Initiation in a Real-world Japanese Cohort: REVIEW-HF Registry. Jma j. 2025;8:281-285. doi: 10.31662/jmaj.2024-0242 32. Tsukada YT, Aoki-Kamiya C, Mizuno A, Nakayama A, Ide T, Aoyama R, Honye J, Hoshina K, Ikegame T, Inoue K, et al. JCS/JCC/JACR/JATS 2024 Guideline on Cardiovascular Practice With Consideration for Diversity, Equity, and Inclusion. Circ J. 2025;89:658-739. doi: 10.1253/circj.CJ-23-0890 33. Tsukada YT, Aoki-Kamiya C, Mizuno A, Nakayama A, Ide T, Aoyama R, Honye J, Hoshina K, Ikegame T, Inoue K, et al. JCS/JCC/JACR/JATS 2024 guideline on cardiovascular practice with consideration for diversity, equity, and inclusion. J Cardiol. 2025;85:510-574. doi: 10.1016/j.jjcc.2025.03.002 34. Terada M, Kagiyama N, Izumi Y, Higuchi R, Saji M, Kitamura M, Takamisawa I, Nanasato M, Iwakura T, Isobe M. Mitral Annular Dynamics After Transcatheter Edge-to-Edge Repair for Functional Mitral Regurgitation: Comparison With Surgical Annuloplasty. J Am Soc Echocardiogr. 2025;38:532-533. doi: 10.1016/j.echo.2025.02.005 35. Tanaka S, Imamura T, Ushijima R, Nakamura M, Fukuda N, Ueno H, Kinugawa K, Yamamoto M, Kubo S, Izumi Y, et al. Safety and Prognostic Implications of Mechanical Circulatory Support-Assisted Transcatheter Edge-to-Edge Repair: The OCEAN-Mitral Registry. J Am Heart Assoc. 2025;14:e042785. doi: 10.1161/jaha.125.042785 36. Takigami Y, Ishii S, Iida Y, Ikeda Y, Nabeta T, Oikawa J, Nasu T, Kanaoka K, Kagiyama N, Kida K, et al. Prognostic Impact of Sustained Reduction of N-Terminal Pro-B-Type Natriuretic Peptide After Initiating Sacubitril/Valsartan　- Insights From the REVIEW-HF Registry. Circ Rep. 2025;7:433-441. doi: 10.1253/circrep.CR-25-0029 37. Suzuki T, Nagasu H, Ebara T, Kagiyama N, Kishi T, Yano Y, Kario K, Nishiyama A, Arima H, Kawai F, et al. Unraveling the Implications of Digit Bias in Digital Health - A Literature Review. Intern Med. 2025;64:2090-2099. doi: 10.2169/internalmedicine.4666-24 38. Sakamoto A, Nakamura Y, Sato E, Kagiyama N. Artificial Intelligence in Clinics: Enhancing Cardiology Practice. Jma j. 2025;8:131-140. doi: 10.31662/jmaj.2024-0190 39. Sakamoto A, Nakamura Y, Kagiyama N, Sato E, Fujita W, Kaneko T, Minamino T. Low Arterial Stiffness by Pulse Wave Analysis and Aortic Diseases. Circ Rep. 2025;7:481-485. doi: 10.1253/circrep.CR-25-0043 40. Sakamoto A, Kaneko T, Sato E, Fujita W, Nakamura Y, Yokotsuka N, Kagiyama N. Artificial intelligence in echocardiography: current applications and future perspectives. J Echocardiogr. 2025;23:231-240. doi: 10.1007/s12574-025-00703-0 41. Sakamoto A, Kaneko T, Kagiyama N. The Rarest of the Rare: Imaging Features of Uncommon Cardiac Tumors. JACC Case Rep. 2025;30:103528. doi: 10.1016/j.jaccas.2025.103528 42. Saito Y, Kagiyama N, Harada T, Kaneko T, Kagami K, Dotare T, Yuasa N, Sato E, Sorimachi H, Murata A, et al. An evidence-based tool for screening for heart failure with preserved ejection fraction in primary care: The BREATH(2) score. J Cardiol. 2025;86:264-271. doi: 10.1016/j.jjcc.2025.03.018 43. Saito K, Nakade T, Kagiyama N, Maeda D, Fujimoto Y, Sunayama T, Dotare T, Jujo K, Kamiya K, Saito H, et al. Sarcopenia in heart failure: Comparison of prognostic value between the Asian working Group for Sarcopenia 2014 and 2019 criteria. Geriatr Gerontol Int. 2025;25:764-771. doi: 10.1111/ggi.70040 44. Saito H, Maeda D, Kagiyama N, Sunayama T, Dotare T, Fujimoto Y, Nakade T, Jujo K, Saito K, Kamiya K, et al. Prognostic importance of the reason for six-minute walk test interruption in hospitalized older patients with heart failure. Geriatr Gerontol Int. 2025;25:1475-1480. doi: 10.1111/ggi.70172 45. Sahashi Y, Ouyang D, Okura H, Kagiyama N. AI-echocardiography: Current status and future direction. J Cardiol. 2025;85:458-464. doi: 10.1016/j.jjcc.2025.02.005 46. Omori N, Amano M, Kaneko T, Sato Y, Ohno Y, Obokata M, Sato K, Okada T, Morita K, Machino-Ohtsuka T, et al. Factors Associated With and Prognosis of Atriogenic Tethering in Patients With Atrial Functional Mitral Regurgitation. Circ J. 2025. doi: 10.1253/circj.CJ-25-0465 47. Okada T, Kagiyama N, Kaneko T, Amano M, Sato Y, Ohno Y, Obokata M, Sato K, Morita K, Machino-Ohtsuka T, et al. Echocardiographic cardiac damage classification and clinical outcomes in atrial functional mitral regurgitation. Heart. 2025;111:532-540. doi: 10.1136/heartjnl-2024-325240 48. Noda T, Kamiya K, Uchida S, Toki M, Saito H, Iwata K, Matsue Y, Yoshioka K, Saito K, Murata A, et al. Prognostic value of ultrasound-assessed upper limb muscle thickness on mortality in older patients with heart failure: A post-hoc analysis of the SONIC-HF cohort study. Nutr Metab Cardiovasc Dis. 2025;35:104219. doi: 10.1016/j.numecd.2025.104219 49. Nishiura N, Kubo S, Ono S, Mushiake K, Osakada K, Maruo T, Kadota K, Yamamoto M, Saji M, Izumi Y, et al. Prognostic value of leaflet coaptation gap in transcatheter edge-to-edge repair for functional mitral regurgitation. Heart. 2025. doi: 10.1136/heartjnl-2024-325585 50. Nakade T, Matsue Y, Ikeda Y, Maeda D, Kagiyama N, Fujimoto Y, Inoue H, Sunayama T, Dotare T, Jujo K, et al. Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF. Eur J Prev Cardiol. 2025. doi: 10.1093/eurjpc/zwaf279 51. Nakade T, Maeda D, Matsue Y, Kagiyama N, Fujimoto Y, Sunayama T, Dotare T, Jujo K, Saito K, Kamiya K, et al. Prognostic Value of Sarcopenia Definitions and Outcomes Consortium Criteria in Older Patients with Heart Failure. J Am Med Dir Assoc. 2025;26:105350. doi: 10.1016/j.jamda.2024.105350 52. Nakade T, Maeda D, Matsue Y, Kagiyama N, Fujimoto Y, Sunayama T, Dotare T, Jujo K, Saito K, Kamiya K, et al. Association of pre-admission exercise habit with post-discharge outcomes for older patients with heart failure. Eur J Prev Cardiol. 2025;32:964-971. doi: 10.1093/eurjpc/zwaf069 53. Nakade T, Maeda D, Matsue Y, Kagiyama N, Fujimoto Y, Sunayama T, Dotare T, Jujo K, Saito K, Kamiya K, et al. Prognostic utility of the Global Leadership Initiative on Sarcopenia model in older patients with heart failure: post-hoc analysis of the FRAGILE-HF study. Eur J Prev Cardiol. 2025. doi: 10.1093/eurjpc/zwaf636 54. Nagahiro T, Konishi M, Kagiyama N, Kasai T, Kamiya K, Saito H, Saito K, Maekawa E, Kitai T, Iwata K, et al. Prognostic value of weight loss in hospitalized patients with heart failure. Eur Heart J Qual Care Clin Outcomes. 2025;11:123-129. doi: 10.1093/ehjqcco/qcae058 55. Murata A, Kaneko T, Amano M, Sato Y, Ohno Y, Obokata M, Sato K, Okada T, Sakamoto A, Hirose N, et al. Qualitative and quantitative assessment of atrial functional mitral regurgitation: analysis from the REVEAL-AFMR registry. Eur Heart J Cardiovasc Imaging. 2025;26:299-306. doi: 10.1093/ehjci/jeae288 56. Murakami T, Kagiyama N, Kaneko T, Kagami K, Amano M, Okada T, Sato Y, Ohno Y, Sato K, Morita K, et al. Characterization of Malnutrition in Atrial Functional Mitral Regurgitation. CJC Open. 2025;7:1038-1047. doi: 10.1016/j.cjco.2025.05.007 57. Misumi K, Matsue Y, Nogi K, Fujimoto Y, Kagiyama N, Kasai T, Kitai T, Oishi S, Akiyama E, Suzuki S, et al. Usefulness of hypochloremia at the time of discharge to predict prognosis in patients with chronic heart failure after hospitalization. J Cardiol. 2025;85:235-240. doi: 10.1016/j.jjcc.2024.08.011 58. Minami K, Sato K, Machino-Ohtsuka T, Kagiyama N. Comparison of clinical characteristics and prognosis of patients with atrial functional mitral regurgitation exhibiting sinus rhythm and atrial fibrillation. Eur Heart J Cardiovasc Imaging. 2025;26:928-930. doi: 10.1093/ehjci/jeaf061 59. Matsuo K, Kamiya K, Maeda D, Hamazaki N, Uchida S, Yamashita M, Konishi M, Kasai T, Saito H, Ogasahara Y, et al. Fat Mass and Cause-Specific Death in Older Patients with Heart Failure. Can J Cardiol. 2025. doi: 10.1016/j.cjca.2025.12.028 60. Maeda D, Matsue Y, Kagiyama N, Fujimoto Y, Sunayama T, Dotare T, Nakade T, Jujo K, Kamiya K, Saito H, et al. Clinical and Prognostic Utility of the Essential Frailty Toolset in Older Patients With Heart Failure. J Am Geriatr Soc. 2025;73:3455-3463. doi: 10.1111/jgs.70103 61. Kubo S, Yamamoto M, Saji M, Asami M, Enta Y, Shirai S, Izumo M, Mizuno S, Watanabe Y, Izumi Y, et al. Real-World Outcomes of the Initial Clip Selection for Transcatheter Edge-to-Edge Repair Using the MitraClip G4 From the Optimized Catheter Valvular Intervention-Mitral Registry. J Am Heart Assoc. 2025;14:e041907. doi: 10.1161/jaha.125.041907 62. Komiyama C, Kagiyama N, Yuri T, Hayashida A, Hirohata A, Yoshida K, Matsue Y, Minamino T. Determinants and Clinical Impact of Visit-to-visit Blood Pressure Variability in Patients with Heart Failure with Preserved Ejection Fraction. Jma j. 2025;8:871-881. doi: 10.31662/jmaj.2024-0256 63. Kobayashi T, Matsue Y, Fujimoto Y, Maeda D, Kida K, Kitai T, Kagiyama N, Yamaguchi T, Okumura T, Mizuno A, et al. Prevalence and Prognostic Implications of Changes in Tricuspid Regurgitation Severity in Acute Heart Failure. J Card Fail. 2025;31:781-788. doi: 10.1016/j.cardfail.2024.08.043 64. Kitai T, Kohsaka S, Kato T, Kato E, Sato K, Teramoto K, Yaku H, Akiyama E, Ando M, Izumi C, et al. JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure. J Card Fail. 2025;31:1164-1322. doi: 10.1016/j.cardfail.2025.02.014 65. Kitai T, Kohsaka S, Kato T, Kato E, Sato K, Teramoto K, Yaku H, Akiyama E, Ando M, Izumi C, et al. JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure. Circ J. 2025;89:1278-1444. doi: 10.1253/circj.CJ-25-0002 66. Kitai T, Kohsaka S, Kato T, Kato E, Sato K, Teramoto K, Yaku H, Akiyama E, Ando M, Izumi C, et al. CORRIGENDUM: JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure. Circ J. 2025;89:1579-1581. doi: 10.1253/circj.CJ-66-0242 67. Kitai T, Kohsaka S, Kato T, Kato E, Sato K, Teramoto K, Yaku H, Akiyama E, Ando M, Izumi C, et al. JCS/JHFS 2025 Guideline on Diagnosis and Treatment of Heart Failure. J Card Fail. 2025. doi: 10.1016/j.cardfail.2025.07.008 68. Kaneko T, Murata A, Amano M, Sato Y, Ohno Y, Obokata M, Sato K, Okada T, Fujita W, Morita K, et al. Characteristics, determinants, and prognostic impact of severe tricuspid regurgitation in patients with atrial functional mitral regurgitation: Insights from the REVEAL-AFMR registry. Eur J Heart Fail. 2025;27:1539-1548. doi: 10.1002/ejhf.3624 69. Kagiyama N, Kasai T, Daida H. Author's reply. J Cardiol. 2025;85:430-431. doi: 10.1016/j.jjcc.2024.11.009 70. Kagiyama N, Kamiya K, Toki M, Saito H, Iwata K, Matsue Y, Yoshioka K, Saito K, Murata A, Hayashida A, et al. Design, Rational, and Baseline Characteristics of the SONIC-HF Multicenter Registry. Jma j. 2025;8:552-559. doi: 10.31662/jmaj.2024-0364 71. Kagiyama N, Kamiya K, Toki M, Saito H, Iwata K, Matsue Y, Yoshioka K, Saito K, Kitai T, Maekawa E. Prognostic Impact of Diaphragm Thickness in Geriatric Patients With Heart Failure: The SONIC-HF Multicenter Registry. JACC Cardiovasc Imaging. 2025;18:389-391. doi: 10.1016/j.jcmg.2024.09.012 72. Kagiyama N. Treatment Strategy of Atrial Functional Mitral Regurgitation: Consideration of the Mechanistic Subtypes. JACC Cardiovasc Imaging. 2025;18:30-32. doi: 10.1016/j.jcmg.2024.07.027 73. Kagami K, Kagiyama N, Kaneko T, Harada T, Sato K, Amano M, Okada T, Sato Y, Ohno Y, Morita K, et al. Heart failure with preserved ejection fraction in atrial functional mitral regurgitation - Insight from the REVEAL-AFMR. Int J Cardiol. 2025;422:132958. doi: 10.1016/j.ijcard.2025.132958 74. 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Eur J Prev Cardiol. 2021;28:1022-1029. doi: 10.1093/eurjpc/zwaa117 149. Kitai T, Shimogai T, Tang WHW, Iwata K, Xanthopoulos A, Otsuka S, Nakada F, Yokoyama R, Kamiya K, Saito H, et al. Short physical performance battery vs. 6-minute walking test in hospitalized elderly patients with heart failure. Eur Heart J Open. 2021;1:oeab006. doi: 10.1093/ehjopen/oeab006 150. Kida K, Kitai T, Suzuki N, Ashikaga K, Kou S, Kagiyama N, Yamaguchi T, Okumura T, Mizuno A, Oishi S, et al. Prognostic Implications of Reductions in Heart Rates in Patients With Acute Heart Failure and Atrial Fibrillation. Circ J. 2021;85:1869-1875. doi: 10.1253/circj.CJ-21-0269 151. Kato T, Kasai T, Suda S, Sato A, Ishiwata S, Yatsu S, Matsumoto H, Shitara J, Shimizu M, Murata A, et al. Prognostic effects of arterial carbon dioxide levels in patients hospitalized into the cardiac intensive care unit for acute heart failure. Eur Heart J Acute Cardiovasc Care. 2021;10:497-502. doi: 10.1093/ehjacc/zuab001 152. Kagiyama N, Toki M, Yuri T, Aritaka S, Hayashida A, Sengupta PP, Yoshida K. Physiological and prognostic differences between types of exercise stress echocardiography for functional mitral regurgitation. Open Heart. 2021;8. doi: 10.1136/openhrt-2021-001583 153. Jujo K, Kagiyama N, Saito K, Kamiya K, Saito H, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, et al. Impact of Social Frailty in Hospitalized Elderly Patients With Heart Failure: A FRAGILE-HF Registry Subanalysis. J Am Heart Assoc. 2021;10:e019954. doi: 10.1161/jaha.120.019954 154. Ishida M, Matsumoto C, Kida K, Fukuda M, Kagiyama N, Kusunose K, Matsumoto S, Nomura S, Okumura T, Shiono Y, et al. New Vision, Mission, and Values of the Japanese Circulation Society. Circ J. 2021;85:2248-2251. doi: 10.1253/circj.CJ-21-0822 155. Hirose S, Matsue Y, Kamiya K, Kagiyama N, Hiki M, Dotare T, Sunayama T, Konishi M, Saito H, Saito K, et al. Prevalence and prognostic implications of malnutrition as defined by GLIM criteria in elderly patients with heart failure. Clin Nutr. 2021;40:4334-4340. doi: 10.1016/j.clnu.2021.01.014 156. Hayasaka K, Matsue Y, Kitai T, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Mizukami A, et al. Tricuspid regurgitation pressure gradient identifies prognostically relevant worsening renal function in acute heart failure. Eur Heart J Cardiovasc Imaging. 2021;22:203-209. doi: 10.1093/ehjci/jeaa035 157. Hasselberg NE, Kagiyama N, Soyama Y, Sugahara M, Goda A, Ryo-Koriyama K, Batel O, Chakinala M, Simon MA, Gorcsan J, 3rd. The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension. J Am Soc Echocardiogr. 2021;34:851-861.e851. doi: 10.1016/j.echo.2021.03.007 158. Yoshioka K, Matsue Y, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Mizukami A, Kuroda S, et al. Impact of brain natriuretic peptide reduction on the worsening renal function in patients with acute heart failure. PLoS One. 2020;15:e0235493. doi: 10.1371/journal.pone.0235493 159. Tokodi M, Shrestha S, Bianco C, Kagiyama N, Casaclang-Verzosa G, Narula J, Sengupta PP. Interpatient Similarities in Cardiac Function: A Platform for Personalized Cardiovascular Medicine. JACC Cardiovasc Imaging. 2020;13:1119-1132. doi: 10.1016/j.jcmg.2019.12.018 160. Sugimoto T, Mizuno A, Kishi T, Ito N, Matsumoto C, Fukuda M, Kagiyama N, Shibata T, Ohmori T, Oishi S, et al. Coronavirus Disease 2019 (COVID-19) Information for Cardiologists　- Systematic Literature Review and Additional Analysis. Circ J. 2020;84:1039-1043. doi: 10.1253/circj.CJ-20-0302 161. Seo Y, Daimon M, Yamada H, Kagiyama N, Ohta M, Izumi C, Yamamoto K, Nakatani S. Review of the efforts of the Japanese Society of Echocardiography for coronavirus disease 2019 (COVID-19) during the initial outbreak in Japan. J Echocardiogr. 2020;18:226-233. doi: 10.1007/s12574-020-00487-5 162. Seo Y, Daimon M, Yamada H, Kagiyama N, Ohta M, Izumi C, Yamamoto K, Nakatani S. Correction to: Review of the efforts of the Japanese Society of Echocardiography for coronavirus disease 2019 (COVID-19) during the initial outbreak in Japan. J Echocardiogr. 2020;18:234. doi: 10.1007/s12574-020-00494-6 163. Sengupta PP, Shrestha S, Berthon B, Messas E, Donal E, Tison GH, Min JK, D'Hooge J, Voigt JU, Dudley J, et al. Proposed Requirements for Cardiovascular Imaging-Related Machine Learning Evaluation (PRIME): A Checklist: Reviewed by the American College of Cardiology Healthcare Innovation Council. JACC Cardiovasc Imaging. 2020;13:2017-2035. doi: 10.1016/j.jcmg.2020.07.015 164. Matsue Y, Kamiya K, Saito H, Saito K, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Jujo K, et al. Prevalence and prognostic impact of the coexistence of multiple frailty domains in elderly patients with heart failure: the FRAGILE-HF cohort study. Eur J Heart Fail. 2020;22:2112-2119. doi: 10.1002/ejhf.1926 165. Matsue Y, Kagiyama N, Yamaguchi T, Kuroda S, Okumura T, Kida K, Mizuno A, Oishi S, Inuzuka Y, Akiyama E, et al. Clinical and Prognostic Values of ALBI Score in Patients With Acute Heart Failure. Heart Lung Circ. 2020;29:1328-1337. doi: 10.1016/j.hlc.2019.12.003 166. Kagiyama N, Sugahara M, Crago EA, Qi Z, Lagattuta TF, Yousef KM, Friedlander RM, Hravnak MT, Gorcsan J, 3rd. Neurocardiac Injury Assessed by Strain Imaging Is Associated With In-Hospital Mortality in Patients With Subarachnoid Hemorrhage. JACC Cardiovasc Imaging. 2020;13:535-546. doi: 10.1016/j.jcmg.2019.02.023 167. Kagiyama N, Shrestha S, Cho JS, Khalil M, Singh Y, Challa A, Casaclang-Verzosa G, Sengupta PP. A low-cost texture-based pipeline for predicting myocardial tissue remodeling and fibrosis using cardiac ultrasound. EBioMedicine. 2020;54:102726. doi: 10.1016/j.ebiom.2020.102726 168. Kagiyama N, Shrestha S. Echocardiographic assessment of mitral regurgitation. J Med Ultrason (2001). 2020;47:59-70. doi: 10.1007/s10396-019-00971-1 169. Kagiyama N, Piccirilli M, Yanamala N, Shrestha S, Farjo PD, Casaclang-Verzosa G, Tarhuni WM, Nezarat N, Budoff MJ, Narula J, et al. Machine Learning Assessment of Left Ventricular Diastolic Function Based on Electrocardiographic Features. J Am Coll Cardiol. 2020;76:930-941. doi: 10.1016/j.jacc.2020.06.061 170. Kagiyama N, Mondillo S, Yoshida K, Mandoli GE, Cameli M. Subtypes of Atrial Functional Mitral Regurgitation: Imaging Insights Into Their Mechanisms and Therapeutic Implications. JACC Cardiovasc Imaging. 2020;13:820-835. doi: 10.1016/j.jcmg.2019.01.040 171. Husaini M, Soyama Y, Kagiyama N, Thakker P, Thangam M, Haque N, Deych E, Sintek M, Lasala J, Gorcsan J, 3rd, et al. Clinical and Echocardiographic Features Associated With Improved Survival in Patients With Severe Aortic Stenosis Undergoing Balloon Aortic Valvuloplasty (BAV). J Invasive Cardiol. 2020;32:E277-e285. doi: 10.25270/jic/20.00098 172. Farjo PD, Yanamala N, Kagiyama N, Patel HB, Casaclang-Verzosa G, Nezarat N, Budoff MJ, Sengupta PP. Prediction of coronary artery calcium scoring from surface electrocardiogram in atherosclerotic cardiovascular disease: a pilot study. Eur Heart J Digit Health. 2020;1:51-61. doi: 10.1093/ehjdh/ztaa008 173. Citro R, Okura H, Ghadri JR, Izumi C, Meimoun P, Izumo M, Dawson D, Kaji S, Eitel I, Kagiyama N, et al. Multimodality imaging in takotsubo syndrome: a joint consensus document of the European Association of Cardiovascular Imaging (EACVI) and the Japanese Society of Echocardiography (JSE). Eur Heart J Cardiovasc Imaging. 2020;21:1184-1207. doi: 10.1093/ehjci/jeaa149 174. Citro R, Okura H, Ghadri JR, Izumi C, Meimoun P, Izumo M, Dawson D, Kaji S, Eitel I, Kagiyama N, et al. Multimodality imaging in takotsubo syndrome: a joint consensus document of the European Association of Cardiovascular Imaging (EACVI) and the Japanese Society of Echocardiography (JSE). J Echocardiogr. 2020;18:199-224. doi: 10.1007/s12574-020-00480-y 175. Citro R, Okura H, Ghadri JR, Izumi C, Meimoun P, Izumo M, Dawson D, Kaji S, Eitel I, Kagiyama N, et al. Correction to: Multimodality imaging in takotsubo syndrome: a joint consensus document of the European Association of Cardiovascular Imaging (EACVI) and the Japanese Society of Echocardiography (JSE). J Echocardiogr. 2020;18:225. doi: 10.1007/s12574-020-00503-8 176. Cho JS, Shrestha S, Kagiyama N, Hu L, Ghaffar YA, Casaclang-Verzosa G, Zeb I, Sengupta PP. A Network-Based "Phenomics" Approach for Discovering Patient Subtypes From High-Throughput Cardiac Imaging Data. JACC Cardiovasc Imaging. 2020;13:1655-1670. doi: 10.1016/j.jcmg.2020.02.008 177. Benjamin MM, Bianco C, Caccamo M, Sokos G, Kagiyama N, Shrestha S, Verzosa G, Sengupta PP. Non-invasive prediction of tissue Doppler-derived E/e' ratio using lung Doppler signals. Eur Heart J Cardiovasc Imaging. 2020;21:994-1004. doi: 10.1093/ehjci/jeaa090 178. Abdul Ghffar Y, Osman M, Shrestha S, Shaukat F, Kagiyama N, Alkhouli M, Raybuck B, Badhwar V, Sengupta PP. Usefulness of Semisupervised Machine-Learning-Based Phenogrouping to Improve Risk Assessment for Patients Undergoing Transcatheter Aortic Valve Implantation. Am J Cardiol. 2020;136:122-130. doi: 10.1016/j.amjcard.2020.08.048 179. Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, et al. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation. 2019;139:2238-2255. doi: 10.1161/circulationaha.118.035889 180. Yoshioka K, Matsue Y, Yamaguchi T, Kitai T, Kagiyama N, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, et al. Safety and Prognostic Impact of Early Treatment with Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients with Acute Heart Failure. Am J Cardiovasc Drugs. 2019;19:597-605. doi: 10.1007/s40256-019-00355-3 181. Sugahara M, Kagiyama N, Hasselberg NE, Blauwet LA, Briller J, Cooper L, Fett JD, Hsich E, Wells G, McNamara D, et al. Global Left Ventricular Strain at Presentation Is Associated with Subsequent Recovery in Patients with Peripartum Cardiomyopathy. J Am Soc Echocardiogr. 2019;32:1565-1573. doi: 10.1016/j.echo.2019.07.018 182. Seetharam K, Kagiyama N, Sengupta PP. Application of mobile health, telemedicine and artificial intelligence to echocardiography. Echo Res Pract. 2019;6:R41-r52. doi: 10.1530/erp-18-0081 183. Saito H, Kagiyama N, Nagano N, Matsumoto K, Yoshioka K, Endo Y, Hayashida A, Matsue Y. Social isolation is associated with 90-day rehospitalization due to heart failure. Eur J Cardiovasc Nurs. 2019;18:16-20. doi: 10.1177/1474515118800113 184. Kagiyama N, Yuri T, Hayashida A, Hirohata A, Yamamoto K, Yoshida K. Visit-to-Visit B-Type Natriuretic Peptide Variability during the Previous Year Has Independent Prognostic Value in Patients with Stable Chronic Heart Failure. Cardiology. 2019;143:92-99. doi: 10.1159/000500823 185. Kagiyama N, Shrestha S, Farjo PD, Sengupta PP. Artificial Intelligence: Practical Primer for Clinical Research in Cardiovascular Disease. J Am Heart Assoc. 2019;8:e012788. doi: 10.1161/jaha.119.012788 186. Kagiyama N, Otsuki Y, Tsunoda M, Yoshitaka H. Multimodality Imaging in Aortic Arch Aneurysm Ruptured Into the Pulmonary Artery. Ann Thorac Surg. 2019;107:e217. doi: 10.1016/j.athoracsur.2018.08.088 187. Kagiyama N, Kitai T, Hayashida A, Yamaguchi T, Okumura T, Kida K, Mizuno A, Oishi S, Inuzuka Y, Akiyama E, et al. Prognostic Value of BNP Reduction During Hospitalization in Patients With Acute Heart Failure. J Card Fail. 2019;25:712-721. doi: 10.1016/j.cardfail.2019.04.004 188. Kagiyama N, Gorcsan J, 3rd. The Authors Reply. JACC Cardiovasc Imaging. 2019;12:2095. doi: 10.1016/j.jcmg.2019.08.004 189. Yoshitani H, Isotani A, Song JK, Shirai S, Umeda H, Jang JY, Onoue T, Toki M, Sun BJ, Kim DH, et al. Surgical as Opposed to Transcatheter Aortic Valve Replacement Improves Basal Interventricular Septal Hypertrophy. Circ J. 2018;82:2887-2895. doi: 10.1253/circj.CJ-18-0390 190. Yamaguchi T, Kitai T, Miyamoto T, Kagiyama N, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, Yamamoto M, et al. Effect of Optimizing Guideline-Directed Medical Therapy Before Discharge on Mortality and Heart Failure Readmission in Patients Hospitalized With Heart Failure With Reduced Ejection Fraction. Am J Cardiol. 2018;121:969-974. doi: 10.1016/j.amjcard.2018.01.006 191. Totsugawa T, Tsunoda M, Kagiyama N, Otsuki Y, Yoshitaka H, Sakaguchi T. Preoperative Simulation Using CT Virtual Endoscopy for Minimally Invasive Surgery of Hypertrophic Obstructive Cardiomyopathy. Int Heart J. 2018;59:637-640. doi: 10.1536/ihj.17-284 192. Takushi H, Hayashida A, Kagiyama N, Toki M, Hirohata A, Yamamoto K, Yoshida K. Paravalvular leakages between sewing cuffs after the second surgery for double valve replacement: evaluation by three-dimensional color-Doppler transesophageal echocardiography. J Echocardiogr. 2018;16:52-53. doi: 10.1007/s12574-017-0353-5 193. Sakaguchi T, Kagiyama N, Toki M, Hiraoka A, Hayashida A, Totsugawa T, Tamura K, Chikazawa G, Yoshitaka H, Yoshida K. Residual Mitral Regurgitation After Repair for Posterior Leaflet Prolapse-Importance of Preoperative Anterior Leaflet Tethering. J Am Heart Assoc. 2018;7. doi: 10.1161/jaha.117.008495 194. Kusunose K, Shibayama K, Iwano H, Izumo M, Kagiyama N, Kurosawa K, Mihara H, Oe H, Onishi T, Onishi T, et al. Reduced variability of visual left ventricular ejection fraction assessment with reference images: The Japanese Association of Young Echocardiography Fellows multicenter study. J Cardiol. 2018;72:74-80. doi: 10.1016/j.jjcc.2018.01.007 195. Kondo T, Okumura T, Matsue Y, Shiraishi A, Kagiyama N, Yamaguchi T, Kuroda S, Kida K, Mizuno A, Oishi S, et al. Specialty-Related Differences in the Acute-Phase Treatment and Prognosis in Patients With Acute Heart Failure　- Insights From REALITY-AHF. Circ J. 2018;83:174-181. doi: 10.1253/circj.CJ-18-0724 196. Kagiyama N, Matsue Y. The time-to-treatment concept in acute heart failure: Lessons and implications from REALITY-AHF. Anatol J Cardiol. 2018;20:125-129. doi: 10.14744/AnatolJCardiol.2018.88935 197. Gorcsan J, 3rd, Kagiyama N. Can global longitudinal strain predict response to cardiac resynchronization therapy? Heart Rhythm. 2018;15:1540-1541. doi: 10.1016/j.hrthm.2018.05.029 198. Matsue Y, Yoshioka K, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, et al. Prognostic importance of sodium level trajectory in acute heart failure. Heart Vessels. 2017;32:1498-1505. doi: 10.1007/s00380-017-1020-5 199. Matsue Y, Ter Maaten JM, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, et al. Early treatment with tolvaptan improves diuretic response in acute heart failure with renal dysfunction. Clin Res Cardiol. 2017;106:802-812. doi: 10.1007/s00392-017-1122-1 200. Matsue Y, Damman K, Voors AA, Kagiyama N, Yamaguchi T, Kuroda S, Okumura T, Kida K, Mizuno A, Oishi S, et al. Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure. J Am Coll Cardiol. 2017;69:3042-3051. doi: 10.1016/j.jacc.2017.04.042 201. Kagiyama N, Toki M, Hayashida A, Ohara M, Hirohata A, Yamamoto K, Totsugawa T, Sakaguchi T, Yoshida K, Isobe M. Prolapse Volume to Prolapse Height Ratio for Differentiating Barlow's Disease From Fibroelastic Deficiency. Circ J. 2017;81:1730-1735. doi: 10.1253/circj.CJ-16-1291 202. Kagiyama N, Nakazato T, Yoshida K, Sakaguchi T. Importance of detailed distribution of branches in giant coronary aneurysm. Eur J Cardiothorac Surg. 2017;51:394. doi: 10.1093/ejcts/ezw309 203. Kagiyama N, Hayashida A, Toki M, Fukuda S, Ohara M, Hirohata A, Yamamoto K, Isobe M, Yoshida K. Insufficient Leaflet Remodeling in Patients With Atrial Fibrillation: Association With the Severity of Mitral Regurgitation. Circ Cardiovasc Imaging. 2017;10. doi: 10.1161/circimaging.116.005451 204. Yoshioka K, Matsue Y, Kagiyama N, Yoshida K, Kume T, Okura H, Suzuki M, Matsumura A, Yoshida K, Hashimoto Y. Recovery from hyponatremia in acute phase is associated with better in-hospital mortality rate in acute heart failure syndrome. J Cardiol. 2016;67:406-411. doi: 10.1016/j.jjcc.2015.12.004 205. Matsue Y, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, Sugi K, et al. Clinical Effectiveness of Tolvaptan in Patients With Acute Heart Failure and Renal Dysfunction. J Card Fail. 2016;22:423-432. doi: 10.1016/j.cardfail.2016.02.007 206. Matsue Y, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, Sugi K, et al. Prognostic impact of early treatment with tolvaptan in patients with acute heart failure and renal dysfunction. Int J Cardiol. 2016;221:188-193. doi: 10.1016/j.ijcard.2016.07.063 207. Matsue Y, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, Sugi K, et al. Corrigendum to "Clinical Effectiveness of Tolvaptan in Patients With Acute Heart Failure and Renal Dysfunction" Journal of Cardiac Failure, Vol. 22, No. 6, June 2016, pp. 423-432. J Card Fail. 2016;22:941. doi: 10.1016/j.cardfail.2016.07.434 208. Matsue Y, Shiraishi A, Kagiyama N, Yoshida K, Kume T, Okura H, Suzuki M, Matsumura A, Yoshida K, Hashimoto Y. Renal function on admission modifies prognostic impact of diuretics in acute heart failure: a propensity score matched and interaction analysis. Heart Vessels. 2016;31:1980-1987. doi: 10.1007/s00380-016-0817-y 209. Kagiyama N, Toki M, Hara M, Fukuda S, Aritaka S, Miki T, Ohara M, Hayashida A, Hirohata A, Yamamoto K, et al. Efficacy and Accuracy of Novel Automated Mitral Valve Quantification: Three-Dimensional Transesophageal Echocardiographic Study. Echocardiography. 2016;33:756-763. doi: 10.1111/echo.13135 210. Kagiyama N, Okura H, Tamada T, Imai K, Yamada R, Kume T, Hayashida A, Neishi Y, Kawamoto T, Yoshida K. Impact of right ventricular involvement on the prognosis of takotsubo cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2016;17:210-216. doi: 10.1093/ehjci/jev145 211. Kagiyama N, Okura H, Matsue Y, Tamada T, Imai K, Yamada R, Kume T, Hayashida A, Neishi Y, Yoshida K. Multiple Unfavorable Echocardiographic Findings in Takotsubo Cardiomyopathy Are Associated with Increased In-Hospital Events and Mortality. J Am Soc Echocardiogr. 2016;29:1179-1187. doi: 10.1016/j.echo.2016.08.021 212. Sumatani I, Kagiyama N, Saito C, Makanae M, Kanetsuna H, Ahn K, Mizukami A, Hashimoto Y. Infective endocarditis with negative blood culture and negative echocardiographic findings. J Echocardiogr. 2015;13:66-68. doi: 10.1007/s12574-015-0242-8 213. Matsue Y, Kagiyama N, Yoshida K, Kume T, Okura H, Suzuki M, Matsumura A, Yoshida K, Hashimoto Y. Carperitide Is Associated With Increased In-Hospital Mortality in Acute Heart Failure: A Propensity Score-Matched Analysis. J Card Fail. 2015;21:859-864. doi: 10.1016/j.cardfail.2015.05.007 214. Kagiyama N, Okura H, Kume T, Hayashida A, Yoshida K. Isolated right ventricular takotsubo cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2015;16:285. doi: 10.1093/ehjci/jeu207 215. Fujita Y, Kagiyama N, Sakuta Y, Tsuge M. Sudden hypoxemia after uneventful laparoscopic cholecystectomy: another form of SAM presentation. BMC Anesthesiol. 2015;15:51. doi: 10.1186/s12871-015-0031-y 216. Kagiyama N, Okura H, Nezuo S, Kawamoto T, Murakami T, Hashimoto Y, Tanemoto K, Yoshida K. Two cases of acute bioprosthetic mitral valve thrombosis immediately after mitral valve replacement. Circulation. 2014;129:e328-330. doi: 10.1161/circulationaha.113.005583 217. Isobe M, Hashimura K, Hiramitsu S, Kagiyama N, Inomata T. [Discussion meeting on the how to manage cardiomyopathy]. Nihon Naika Gakkai Zasshi. 2014;103:408-424; quiz 425-432. doi: 10.2169/naika.103.408

研究テーマ

循環器内科学、デジタルヘルス、人工知能

研究業績（論文）

1. Yoshikawa M, Otsuki H, Kawamoto T, Shibahashi E, Inagaki Y, Saito-Koyanagi C, Kogure T, Yamaguchi J, Yamamoto M, Kubo S, et al. Prognostic impact of regurgitant volume to left atrial volume ratio on ventricular functional mitral regurgitation. Eur Heart J Cardiovasc Imaging. 2026;27:174-184. doi: 10.1093/ehjci/jeaf304
2. Yamada Y, Konishi M, Kagiyama N, Kasai T, Kamiya K, Saito H, Maekawa E, Kitai T, Iwata K, Jujo K, et al. Prognostic impact of residual symptoms under low and normal physical performance in older patients hospitalized for worsening heart failure. Arch Gerontol Geriatr. 2026;147:106253. doi: 10.1016/j.archger.2026.106253
3. Yamada K, Kagiyama N, Morisawa T, Saitoh M, Iwata K, Kato M, Sakurada K, Kono Y, Iida Y, Taya M, et al. Machine learning prediction of 1-year mortality in older patients with heart failure: a nationwide, multicenter, prospective cohort study. Lancet Reg Health West Pac. 2026;67:101808. doi: 10.1016/j.lanwpc.2026.101808
4. Watanabe Y, Kubota Y, Murata H, Uchiyama S, Asai K, Nasu T, Ishii S, Kagiyama N, Kida K, Fujimoto W, et al. Relevant Adverse Events and Drug Discontinuation of Sacubitril/Valsartan in Patients with Transthyretin Amyloid Cardiomyopathy - Insights from the REVIEW-HF Registry. Int Heart J. 2026;67:221-227. doi: 10.1536/ihj.25-686
5. Unger A, Mandoli GE, Neglia D, Romero Dorta E, Kagiyama N, Borodzicz-Jazdzyk S, Velegraki E, Coisne A, Uygur B, Afana A, et al. Rational and design of EACVI-MMVD study: an international registry on multimodality imaging for mixed and multiple valvular heart disease. Eur Heart J Imaging Methods Pract. 2026;4:qyaf156. doi: 10.1093/ehjimp/qyaf156
6. Uchida S, Kamiya K, Yamashita M, Noda T, Kagiyama N, Matsue Y. Current findings and challenges on frailty, sarcopenia, and cachexia in older patients with heart failure: insights from the FRAGILE-HF study. J Cardiol. 2026;87:10-16. doi: 10.1016/j.jjcc.2025.05.013
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159. Tokodi M, Shrestha S, Bianco C, Kagiyama N, Casaclang-Verzosa G, Narula J, Sengupta PP. Interpatient Similarities in Cardiac Function: A Platform for Personalized Cardiovascular Medicine. JACC Cardiovasc Imaging. 2020;13:1119-1132. doi: 10.1016/j.jcmg.2019.12.018
160. Sugimoto T, Mizuno A, Kishi T, Ito N, Matsumoto C, Fukuda M, Kagiyama N, Shibata T, Ohmori T, Oishi S, et al. Coronavirus Disease 2019 (COVID-19) Information for Cardiologists　- Systematic Literature Review and Additional Analysis. Circ J. 2020;84:1039-1043. doi: 10.1253/circj.CJ-20-0302
161. Seo Y, Daimon M, Yamada H, Kagiyama N, Ohta M, Izumi C, Yamamoto K, Nakatani S. Review of the efforts of the Japanese Society of Echocardiography for coronavirus disease 2019 (COVID-19) during the initial outbreak in Japan. J Echocardiogr. 2020;18:226-233. doi: 10.1007/s12574-020-00487-5
162. Seo Y, Daimon M, Yamada H, Kagiyama N, Ohta M, Izumi C, Yamamoto K, Nakatani S. Correction to: Review of the efforts of the Japanese Society of Echocardiography for coronavirus disease 2019 (COVID-19) during the initial outbreak in Japan. J Echocardiogr. 2020;18:234. doi: 10.1007/s12574-020-00494-6
163. Sengupta PP, Shrestha S, Berthon B, Messas E, Donal E, Tison GH, Min JK, D'Hooge J, Voigt JU, Dudley J, et al. Proposed Requirements for Cardiovascular Imaging-Related Machine Learning Evaluation (PRIME): A Checklist: Reviewed by the American College of Cardiology Healthcare Innovation Council. JACC Cardiovasc Imaging. 2020;13:2017-2035. doi: 10.1016/j.jcmg.2020.07.015
164. Matsue Y, Kamiya K, Saito H, Saito K, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Jujo K, et al. Prevalence and prognostic impact of the coexistence of multiple frailty domains in elderly patients with heart failure: the FRAGILE-HF cohort study. Eur J Heart Fail. 2020;22:2112-2119. doi: 10.1002/ejhf.1926
165. Matsue Y, Kagiyama N, Yamaguchi T, Kuroda S, Okumura T, Kida K, Mizuno A, Oishi S, Inuzuka Y, Akiyama E, et al. Clinical and Prognostic Values of ALBI Score in Patients With Acute Heart Failure. Heart Lung Circ. 2020;29:1328-1337. doi: 10.1016/j.hlc.2019.12.003
166. Kagiyama N, Sugahara M, Crago EA, Qi Z, Lagattuta TF, Yousef KM, Friedlander RM, Hravnak MT, Gorcsan J, 3rd. Neurocardiac Injury Assessed by Strain Imaging Is Associated With In-Hospital Mortality in Patients With Subarachnoid Hemorrhage. JACC Cardiovasc Imaging. 2020;13:535-546. doi: 10.1016/j.jcmg.2019.02.023
167. Kagiyama N, Shrestha S, Cho JS, Khalil M, Singh Y, Challa A, Casaclang-Verzosa G, Sengupta PP. A low-cost texture-based pipeline for predicting myocardial tissue remodeling and fibrosis using cardiac ultrasound. EBioMedicine. 2020;54:102726. doi: 10.1016/j.ebiom.2020.102726
168. Kagiyama N, Shrestha S. Echocardiographic assessment of mitral regurgitation. J Med Ultrason (2001). 2020;47:59-70. doi: 10.1007/s10396-019-00971-1
169. Kagiyama N, Piccirilli M, Yanamala N, Shrestha S, Farjo PD, Casaclang-Verzosa G, Tarhuni WM, Nezarat N, Budoff MJ, Narula J, et al. Machine Learning Assessment of Left Ventricular Diastolic Function Based on Electrocardiographic Features. J Am Coll Cardiol. 2020;76:930-941. doi: 10.1016/j.jacc.2020.06.061
170. Kagiyama N, Mondillo S, Yoshida K, Mandoli GE, Cameli M. Subtypes of Atrial Functional Mitral Regurgitation: Imaging Insights Into Their Mechanisms and Therapeutic Implications. JACC Cardiovasc Imaging. 2020;13:820-835. doi: 10.1016/j.jcmg.2019.01.040
171. Husaini M, Soyama Y, Kagiyama N, Thakker P, Thangam M, Haque N, Deych E, Sintek M, Lasala J, Gorcsan J, 3rd, et al. Clinical and Echocardiographic Features Associated With Improved Survival in Patients With Severe Aortic Stenosis Undergoing Balloon Aortic Valvuloplasty (BAV). J Invasive Cardiol. 2020;32:E277-e285. doi: 10.25270/jic/20.00098
172. Farjo PD, Yanamala N, Kagiyama N, Patel HB, Casaclang-Verzosa G, Nezarat N, Budoff MJ, Sengupta PP. Prediction of coronary artery calcium scoring from surface electrocardiogram in atherosclerotic cardiovascular disease: a pilot study. Eur Heart J Digit Health. 2020;1:51-61. doi: 10.1093/ehjdh/ztaa008
173. Citro R, Okura H, Ghadri JR, Izumi C, Meimoun P, Izumo M, Dawson D, Kaji S, Eitel I, Kagiyama N, et al. Multimodality imaging in takotsubo syndrome: a joint consensus document of the European Association of Cardiovascular Imaging (EACVI) and the Japanese Society of Echocardiography (JSE). Eur Heart J Cardiovasc Imaging. 2020;21:1184-1207. doi: 10.1093/ehjci/jeaa149
174. Citro R, Okura H, Ghadri JR, Izumi C, Meimoun P, Izumo M, Dawson D, Kaji S, Eitel I, Kagiyama N, et al. Multimodality imaging in takotsubo syndrome: a joint consensus document of the European Association of Cardiovascular Imaging (EACVI) and the Japanese Society of Echocardiography (JSE). J Echocardiogr. 2020;18:199-224. doi: 10.1007/s12574-020-00480-y
175. Citro R, Okura H, Ghadri JR, Izumi C, Meimoun P, Izumo M, Dawson D, Kaji S, Eitel I, Kagiyama N, et al. Correction to: Multimodality imaging in takotsubo syndrome: a joint consensus document of the European Association of Cardiovascular Imaging (EACVI) and the Japanese Society of Echocardiography (JSE). J Echocardiogr. 2020;18:225. doi: 10.1007/s12574-020-00503-8
176. Cho JS, Shrestha S, Kagiyama N, Hu L, Ghaffar YA, Casaclang-Verzosa G, Zeb I, Sengupta PP. A Network-Based "Phenomics" Approach for Discovering Patient Subtypes From High-Throughput Cardiac Imaging Data. JACC Cardiovasc Imaging. 2020;13:1655-1670. doi: 10.1016/j.jcmg.2020.02.008
177. Benjamin MM, Bianco C, Caccamo M, Sokos G, Kagiyama N, Shrestha S, Verzosa G, Sengupta PP. Non-invasive prediction of tissue Doppler-derived E/e' ratio using lung Doppler signals. Eur Heart J Cardiovasc Imaging. 2020;21:994-1004. doi: 10.1093/ehjci/jeaa090
178. Abdul Ghffar Y, Osman M, Shrestha S, Shaukat F, Kagiyama N, Alkhouli M, Raybuck B, Badhwar V, Sengupta PP. Usefulness of Semisupervised Machine-Learning-Based Phenogrouping to Improve Risk Assessment for Patients Undergoing Transcatheter Aortic Valve Implantation. Am J Cardiol. 2020;136:122-130. doi: 10.1016/j.amjcard.2020.08.048
179. Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, et al. BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension. Circulation. 2019;139:2238-2255. doi: 10.1161/circulationaha.118.035889
180. Yoshioka K, Matsue Y, Yamaguchi T, Kitai T, Kagiyama N, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, et al. Safety and Prognostic Impact of Early Treatment with Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients with Acute Heart Failure. Am J Cardiovasc Drugs. 2019;19:597-605. doi: 10.1007/s40256-019-00355-3
181. Sugahara M, Kagiyama N, Hasselberg NE, Blauwet LA, Briller J, Cooper L, Fett JD, Hsich E, Wells G, McNamara D, et al. Global Left Ventricular Strain at Presentation Is Associated with Subsequent Recovery in Patients with Peripartum Cardiomyopathy. J Am Soc Echocardiogr. 2019;32:1565-1573. doi: 10.1016/j.echo.2019.07.018
182. Seetharam K, Kagiyama N, Sengupta PP. Application of mobile health, telemedicine and artificial intelligence to echocardiography. Echo Res Pract. 2019;6:R41-r52. doi: 10.1530/erp-18-0081
183. Saito H, Kagiyama N, Nagano N, Matsumoto K, Yoshioka K, Endo Y, Hayashida A, Matsue Y. Social isolation is associated with 90-day rehospitalization due to heart failure. Eur J Cardiovasc Nurs. 2019;18:16-20. doi: 10.1177/1474515118800113
184. Kagiyama N, Yuri T, Hayashida A, Hirohata A, Yamamoto K, Yoshida K. Visit-to-Visit B-Type Natriuretic Peptide Variability during the Previous Year Has Independent Prognostic Value in Patients with Stable Chronic Heart Failure. Cardiology. 2019;143:92-99. doi: 10.1159/000500823
185. Kagiyama N, Shrestha S, Farjo PD, Sengupta PP. Artificial Intelligence: Practical Primer for Clinical Research in Cardiovascular Disease. J Am Heart Assoc. 2019;8:e012788. doi: 10.1161/jaha.119.012788
186. Kagiyama N, Otsuki Y, Tsunoda M, Yoshitaka H. Multimodality Imaging in Aortic Arch Aneurysm Ruptured Into the Pulmonary Artery. Ann Thorac Surg. 2019;107:e217. doi: 10.1016/j.athoracsur.2018.08.088
187. Kagiyama N, Kitai T, Hayashida A, Yamaguchi T, Okumura T, Kida K, Mizuno A, Oishi S, Inuzuka Y, Akiyama E, et al. Prognostic Value of BNP Reduction During Hospitalization in Patients With Acute Heart Failure. J Card Fail. 2019;25:712-721. doi: 10.1016/j.cardfail.2019.04.004
188. Kagiyama N, Gorcsan J, 3rd. The Authors Reply. JACC Cardiovasc Imaging. 2019;12:2095. doi: 10.1016/j.jcmg.2019.08.004
189. Yoshitani H, Isotani A, Song JK, Shirai S, Umeda H, Jang JY, Onoue T, Toki M, Sun BJ, Kim DH, et al. Surgical as Opposed to Transcatheter Aortic Valve Replacement Improves Basal Interventricular Septal Hypertrophy. Circ J. 2018;82:2887-2895. doi: 10.1253/circj.CJ-18-0390
190. Yamaguchi T, Kitai T, Miyamoto T, Kagiyama N, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, Yamamoto M, et al. Effect of Optimizing Guideline-Directed Medical Therapy Before Discharge on Mortality and Heart Failure Readmission in Patients Hospitalized With Heart Failure With Reduced Ejection Fraction. Am J Cardiol. 2018;121:969-974. doi: 10.1016/j.amjcard.2018.01.006
191. Totsugawa T, Tsunoda M, Kagiyama N, Otsuki Y, Yoshitaka H, Sakaguchi T. Preoperative Simulation Using CT Virtual Endoscopy for Minimally Invasive Surgery of Hypertrophic Obstructive Cardiomyopathy. Int Heart J. 2018;59:637-640. doi: 10.1536/ihj.17-284
192. Takushi H, Hayashida A, Kagiyama N, Toki M, Hirohata A, Yamamoto K, Yoshida K. Paravalvular leakages between sewing cuffs after the second surgery for double valve replacement: evaluation by three-dimensional color-Doppler transesophageal echocardiography. J Echocardiogr. 2018;16:52-53. doi: 10.1007/s12574-017-0353-5
193. Sakaguchi T, Kagiyama N, Toki M, Hiraoka A, Hayashida A, Totsugawa T, Tamura K, Chikazawa G, Yoshitaka H, Yoshida K. Residual Mitral Regurgitation After Repair for Posterior Leaflet Prolapse-Importance of Preoperative Anterior Leaflet Tethering. J Am Heart Assoc. 2018;7. doi: 10.1161/jaha.117.008495
194. Kusunose K, Shibayama K, Iwano H, Izumo M, Kagiyama N, Kurosawa K, Mihara H, Oe H, Onishi T, Onishi T, et al. Reduced variability of visual left ventricular ejection fraction assessment with reference images: The Japanese Association of Young Echocardiography Fellows multicenter study. J Cardiol. 2018;72:74-80. doi: 10.1016/j.jjcc.2018.01.007
195. Kondo T, Okumura T, Matsue Y, Shiraishi A, Kagiyama N, Yamaguchi T, Kuroda S, Kida K, Mizuno A, Oishi S, et al. Specialty-Related Differences in the Acute-Phase Treatment and Prognosis in Patients With Acute Heart Failure　- Insights From REALITY-AHF. Circ J. 2018;83:174-181. doi: 10.1253/circj.CJ-18-0724
196. Kagiyama N, Matsue Y. The time-to-treatment concept in acute heart failure: Lessons and implications from REALITY-AHF. Anatol J Cardiol. 2018;20:125-129. doi: 10.14744/AnatolJCardiol.2018.88935
197. Gorcsan J, 3rd, Kagiyama N. Can global longitudinal strain predict response to cardiac resynchronization therapy? Heart Rhythm. 2018;15:1540-1541. doi: 10.1016/j.hrthm.2018.05.029
198. Matsue Y, Yoshioka K, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, et al. Prognostic importance of sodium level trajectory in acute heart failure. Heart Vessels. 2017;32:1498-1505. doi: 10.1007/s00380-017-1020-5
199. Matsue Y, Ter Maaten JM, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, et al. Early treatment with tolvaptan improves diuretic response in acute heart failure with renal dysfunction. Clin Res Cardiol. 2017;106:802-812. doi: 10.1007/s00392-017-1122-1
200. Matsue Y, Damman K, Voors AA, Kagiyama N, Yamaguchi T, Kuroda S, Okumura T, Kida K, Mizuno A, Oishi S, et al. Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure. J Am Coll Cardiol. 2017;69:3042-3051. doi: 10.1016/j.jacc.2017.04.042
201. Kagiyama N, Toki M, Hayashida A, Ohara M, Hirohata A, Yamamoto K, Totsugawa T, Sakaguchi T, Yoshida K, Isobe M. Prolapse Volume to Prolapse Height Ratio for Differentiating Barlow's Disease From Fibroelastic Deficiency. Circ J. 2017;81:1730-1735. doi: 10.1253/circj.CJ-16-1291
202. Kagiyama N, Nakazato T, Yoshida K, Sakaguchi T. Importance of detailed distribution of branches in giant coronary aneurysm. Eur J Cardiothorac Surg. 2017;51:394. doi: 10.1093/ejcts/ezw309
203. Kagiyama N, Hayashida A, Toki M, Fukuda S, Ohara M, Hirohata A, Yamamoto K, Isobe M, Yoshida K. Insufficient Leaflet Remodeling in Patients With Atrial Fibrillation: Association With the Severity of Mitral Regurgitation. Circ Cardiovasc Imaging. 2017;10. doi: 10.1161/circimaging.116.005451
204. Yoshioka K, Matsue Y, Kagiyama N, Yoshida K, Kume T, Okura H, Suzuki M, Matsumura A, Yoshida K, Hashimoto Y. Recovery from hyponatremia in acute phase is associated with better in-hospital mortality rate in acute heart failure syndrome. J Cardiol. 2016;67:406-411. doi: 10.1016/j.jjcc.2015.12.004
205. Matsue Y, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, Sugi K, et al. Clinical Effectiveness of Tolvaptan in Patients With Acute Heart Failure and Renal Dysfunction. J Card Fail. 2016;22:423-432. doi: 10.1016/j.cardfail.2016.02.007
206. Matsue Y, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, Sugi K, et al. Prognostic impact of early treatment with tolvaptan in patients with acute heart failure and renal dysfunction. Int J Cardiol. 2016;221:188-193. doi: 10.1016/j.ijcard.2016.07.063
207. Matsue Y, Suzuki M, Torii S, Yamaguchi S, Fukamizu S, Ono Y, Fujii H, Kitai T, Nishioka T, Sugi K, et al. Corrigendum to "Clinical Effectiveness of Tolvaptan in Patients With Acute Heart Failure and Renal Dysfunction" Journal of Cardiac Failure, Vol. 22, No. 6, June 2016, pp. 423-432. J Card Fail. 2016;22:941. doi: 10.1016/j.cardfail.2016.07.434
208. Matsue Y, Shiraishi A, Kagiyama N, Yoshida K, Kume T, Okura H, Suzuki M, Matsumura A, Yoshida K, Hashimoto Y. Renal function on admission modifies prognostic impact of diuretics in acute heart failure: a propensity score matched and interaction analysis. Heart Vessels. 2016;31:1980-1987. doi: 10.1007/s00380-016-0817-y
209. Kagiyama N, Toki M, Hara M, Fukuda S, Aritaka S, Miki T, Ohara M, Hayashida A, Hirohata A, Yamamoto K, et al. Efficacy and Accuracy of Novel Automated Mitral Valve Quantification: Three-Dimensional Transesophageal Echocardiographic Study. Echocardiography. 2016;33:756-763. doi: 10.1111/echo.13135
210. Kagiyama N, Okura H, Tamada T, Imai K, Yamada R, Kume T, Hayashida A, Neishi Y, Kawamoto T, Yoshida K. Impact of right ventricular involvement on the prognosis of takotsubo cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2016;17:210-216. doi: 10.1093/ehjci/jev145
211. Kagiyama N, Okura H, Matsue Y, Tamada T, Imai K, Yamada R, Kume T, Hayashida A, Neishi Y, Yoshida K. Multiple Unfavorable Echocardiographic Findings in Takotsubo Cardiomyopathy Are Associated with Increased In-Hospital Events and Mortality. J Am Soc Echocardiogr. 2016;29:1179-1187. doi: 10.1016/j.echo.2016.08.021
212. Sumatani I, Kagiyama N, Saito C, Makanae M, Kanetsuna H, Ahn K, Mizukami A, Hashimoto Y. Infective endocarditis with negative blood culture and negative echocardiographic findings. J Echocardiogr. 2015;13:66-68. doi: 10.1007/s12574-015-0242-8
213. Matsue Y, Kagiyama N, Yoshida K, Kume T, Okura H, Suzuki M, Matsumura A, Yoshida K, Hashimoto Y. Carperitide Is Associated With Increased In-Hospital Mortality in Acute Heart Failure: A Propensity Score-Matched Analysis. J Card Fail. 2015;21:859-864. doi: 10.1016/j.cardfail.2015.05.007
214. Kagiyama N, Okura H, Kume T, Hayashida A, Yoshida K. Isolated right ventricular takotsubo cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2015;16:285. doi: 10.1093/ehjci/jeu207
215. Fujita Y, Kagiyama N, Sakuta Y, Tsuge M. Sudden hypoxemia after uneventful laparoscopic cholecystectomy: another form of SAM presentation. BMC Anesthesiol. 2015;15:51. doi: 10.1186/s12871-015-0031-y
216. Kagiyama N, Okura H, Nezuo S, Kawamoto T, Murakami T, Hashimoto Y, Tanemoto K, Yoshida K. Two cases of acute bioprosthetic mitral valve thrombosis immediately after mitral valve replacement. Circulation. 2014;129:e328-330. doi: 10.1161/circulationaha.113.005583
217. Isobe M, Hashimura K, Hiramitsu S, Kagiyama N, Inomata T. [Discussion meeting on the how to manage cardiomyopathy]. Nihon Naika Gakkai Zasshi. 2014;103:408-424; quiz 425-432. doi: 10.2169/naika.103.408

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鍵山 暢之（カギヤマ ノブユキ）

鍵山暢之（カギヤマノブユキ）