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研究業績詳細

加藤 忠史（カトウ タダフミ）

研究テーマ 双極性障害の神経生物学的研究
研究業績（論文） Selected peer-reviewed publications

1. Nishioka M, Sakashita-Kubota M, Iijima K, Hasegawa Y, Ishiwata M, Takase K, Ichikawa R, Mechawar N, Turecki G, Kato T (2026) Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis. Nature Communications 17:1338.
2. Okumura Y, Tamune H, Harada2 H, Kato T* (2026) Real-world effectiveness of mono- and combination therapies of mood stabilizers and antipsychotics in bipolar disorder: A nationwide within-individual study of 315,046 patients. British J Psychiatry, April 30/2026.
3. Nagakura A, Kawakami I, Kimura A, Ikeda K, Oshima K, Kubota-Sakashita M, Kato T (2025)　Increased granulovacuolar degeneration in the thalamus and higher neurofibrillary tangle Braak stages in bipolar disorder.　Psychiatry Clin Neurosci. 79: 801-807.
4. Nishioka M, Tanei ZI, Saito Y, Morishima M, Hino M, Mori K, Nagaoka A, Shishido R, Saito R, Kitamura H, Nagakura A, Kimura A, Iritani S, Oshima K, Kakita A, Kunii Y, Murayama S, Kato T (2025) Mosaic variants of neurodevelopmental and mitochondrial genes in postmortem paraventricular thalamus in bipolar disorder detected by deep exome sequencing. Psychiatry Clin Neurosci. 79: 653-666.
5. Ohtani H, Ichikawa R, Mori K, Kato T*, Nishioka M* (2025) Single-molecule DNA analysis of mitochondrial heteroplasmic variants in the brains of patients with bipolar disorder. Mol Psychiatry 30: 4764-477
6. Singh B, Swartz HA, Cuellar-Barboza AB, Schaffer A, Kato T, Dols A, Sperry SH, Vassilev AB, Burdick KE, Frye MA (in press) Bipolar Disorders. Lancet
7. Nakamura T, Yoshihara T, Tanegashima C, Kadota M, Kobayashi Y, Honda K, Ishiwata M, Ueda J, Hara T, Nakanishi M, Takumi T, Itohara S, Kuraku S, Asano M, Kasahara T, Nakajima K, Tsuboi T, Takata A, Kato T (2024) Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor. Mol Psychiatry, 29: 2888-2904.
8. Kubota-Sakashita M*, Kawakami H, Kikuzato K, Shirai F, Nakamura T, Kato T* (2024) An ex vivo screening using mouse brain mitochondria identified seco-cycline D as an inhibitor of mitochondrial permeability transition pore. Biocheml Biophys Research Commun, 691:149253.
9. Nishioka M*, Takayama J, Sakai N, Kazuno A, Ishiwata M, Ueda J, Hayama T, Fujii K, Someya T, Kuriyama S, Tamiya G, Takata A*, Kato T* (2023). Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder. Molecular Psychiatry, May 30.
10. Yamamoto H, Lee-Okada HC, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T*, Kasahara T*(2023). GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Molecular Psychiatry, Feb 21, 2023.
11. Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki A, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H (2023). Highly prevalent NF-κB signaling pathway-activating somatic mutations in intracranial aneurysms. Science Translational Medicine, Jun 14.
12. Nishioka M, Kazuno A, Nakamura T, Sakai N, Hayama T, Fujii K, Matsuo K, Komori A, Ishiwata M, Watanabe Y, Oka T, Matoba N, Kataoka M, Alkanaq AN, Hamanaka K, Tsuboi T, Sengoku T, Ogata K, Iwata N, Ikeda M, Matsumoto N, Kato T#, Takata A# (2021) Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder. Nature Communications 12: 3750. (# co-corresponding authors in alphabetical order)
13. Bundo M*, Ueda J*, Nakachi Y, Kasai K, Kato T#, Iwamoto K#. Decreased DNA methylation at promoters and gene-specific neuronal hypermethylation in the prefrontal cortex of patients with bipolar disorder. Molecular Psychiatry April 20, 2021 (# co-corresponding authors)
14. Kato TM, Kubota-Sakashita M, Fujimori-Tonou N, Saitow F, Fuke S, Masuda A, Itohara S, Suzuki H, Kato T* (2018). Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder. Molecular Psychiatry 23: 2039–2049
15. Takata A*, Matsumoto N, Kato T* (2017) Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci. Nature Communications 8: 14519
16. Hou L, —— Kato T (112 of 123 authors), —— McMahon FJ*, Schulze TG* (2016) Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet 38: 1085-1093
17. Kataoka M#, Matoba N#, Sawada T, Kazuno AA, Ishiwata M, Fujii K, Matsuo K, Takata A*, Kato T* (2016) Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations. Molecular Psychiatry 21: 885-893
18. Kasahara T#, Takata A#, Kato TM#, Kubota-Sakashita M, Sawada T, Kakita A, Mizukami H, Kaneda D, Ozawa K, Kato T* (2016) Depression-like Episodes in Mice Harboring mtDNA Deletions in Paraventricular Thalamus. Molecular Psychiatry 21: 39-48
19. Consortium on Lithium Genetics, Hou L, Heilbronner U, Rietschel M, Kato T, Kuo PH, McMahon FJ*, and Schulze TG* (2014) Variant GADL1 and response to lithium in bipolar I disorder. New England Journal of Medicine 370: 1857-1859
20. Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T*, Iwamoto K* (2014) Increased L1 retrotransposition in the neuronal genome in schizophrenia. Neuron, 81: 306-313
21. Iwamoto K*, Bundo M, Ueda J, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T* (2011) Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Research 21: 688-696
22. Kasahara T*, Abe K, Mekada K, Yoshiki A, Kato T* (2010) Genetic variation of melatonin productivity in laboratory mice under domestication. Proceedings of the National Academy of Sciences of the United States of America 107: 6412-6417
23. Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, Tomonaga S, Watanabe Y, Chung YJ, Banerjee R, Iwamoto K, Kato T, Okazawa M, Yamauchi K, Tanda K, Takao K, Miyakawa T, Bradley A, Takumi T (2009) Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell 137: 1235-1246
24. Oldham MC, Konopka G, Iwamoto K, Langfelder P, Kato T, Horvath S, Geschwind DH (2008) Functional organization of the transcriptome in human brain. Nature Neuroscience 11: 1271－1282
25. Kazuno A, Munakata K, Nagai T, Shimozono S, Tanaka M, Yoneda M, Kato N, Miyawaki A, Kato T* (2006) Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics. PLoS Genetics 2: e128
26. Iwamoto K, Bundo M, Kato T* (2005) Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Human Molecular Genetics 14: 241-253
27. Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T* (2003) Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nature Genetics 35: 171-175
28. Kasahara T, Kato T* (2003) A new redox-cofactor vitamin for mammals. Nature 422: 832

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