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野中里紗（ノナカリサ）

研究テーマ	細胞外マトリックスに着目した細胞機能解析、iPS細胞を用いた神経変性疾患の解析
研究業績（論文）	1.Long-Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease. Kensuke Daida Manabu Funayama Kimberley J Billingsley Laksh Malik Abigail Miano-Burkhardt Hampton L Leonard Mary B Makarious Hirotaka Iwaki Jinhui Ding J Raphael Gibbs Mayu Ishiguro Hiroyo Yoshino Kotaro Ogaki Genko Oyama Kenya Nishioka Risa Nonaka Wado Akamatsu Cornelis Blauwendraat Nobutaka Hattori Movement disorders 38(12):2249-2257 2023年12月 2. A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease. Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-Ichi Ishikawa, Nobutaka Hattori Frontiers in neuroscience 17 1202027-1202027 2023年 3. Increased Risk of Aortic Dissection with Perlecan Deficiency. Risa Nonaka, Takafumi Iesaki, Aurelien Kerever, Eri Arikawa-Hirasawa International journal of molecular sciences 23(1) 2021年12月28日 4. Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells. Kei-Ichi Ishikawa, Risa Nonaka, Wado Akamatsu Methods in molecular biology (Clifton, N.J.) 2322 73-80 2021年 5. Mutations in CHCHD2 cause α-synuclein aggregation. Ikeda A, Nishioka K, Meng H, Takanashi M, Hasegawa I, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa K-I, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori, N Human Molecular Genetics, 28 (23), pp. 3895-3911. 2019年10月 6. NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy. Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N EMBO Reports, 19 (12), art. no. e46363 2018年10月 7. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K Proceedings of the National Academy of Sciences of the United States of America 115(25) E5815-E5823 2018年6月 8. Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche. Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E Journal of neurochemistry 142(4) 534-544 2017年8月 9. Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression. Sadatsuki R, Kaneko H, Kinoshita M, Futami I, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M Journal of orthopaedic research : official publication of the Orthopaedic Research Society 35(4) 837-846 2017年4月 10. Identification of peptides derived from the C-terminal domain of fibulin-7 active for endothelial cell adhesion and tube formation disruption. de Vega S, Hozumi K, Suzuki N, Nonaka R, Seo E, Takeda A, Ikeuchi T, Nomizu M, Yamada Y, Arikawa-Hirasawa E Biopolymers 106(2) 184-195 2016年3月 11. Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle. Ning L, Xu Z, Furuya N, Nonaka R, Yamada Y, Arikawa-Hirasawa E Matrix biology : journal of the International Society for Matrix Biology 48 26-35 2015年10月 12. A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space. Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K Neuromuscular disorders : NMD 25(8) 667-671 2015年8月 13. Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase. Nonaka R, Iesaki T, de Vega S, Daida H, Okada T, Sasaki T, Arikawa-Hirasawa E Physiological reports 3(1) 2015年1月 14. Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathway. Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-Hirasawa E The American journal of pathology 184(6) 1683-1694 2014年6月 15. Perlecan is required for FGF-2 signaling in the neural stem cell niche. Kerever A, Mercier F, Nonaka R, de Vega S, Oda Y, Zalc B, Okada Y, Hattori N, Yamada Y, Arikawa-Hirasawa E Stem cell research 12(2) 492-505 2014年3月 16. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture. de Vega S, Suzuki N, Nonaka R, Sasaki T, Forcinito P, Arikawa-Hirasawa E, Yamada Y Archives of biochemistry and biophysics 545 148-153 2014年3月 17. Domain 36 of tropoelastin in elastic fiber formation. Nonaka R, Sato F, Wachi H Biological & pharmaceutical bulletin 37(4) 698-702 2014年 18. Involvement of reactive oxygen species in abnormal tropoelastin deposition induced by UVA-photosensitizers Satoshi Onoue, Risa Nonaka, Fumiaki Sato, Chiharu Koide, Akinobu Hayashi, Hiroshi Wachi Journal of Health Science 55 946-951 2009年12月 19. DANCE/fibulin-5 promotes elastic fiber formation in a tropoelastin isoform-dependent manner. Nonaka R, Onoue S, Wachi H, Sato F, Urban Z, Starcher BC, Seyama Y Clinical biochemistry 42(7-8) 713-721 2009年5月 20. Characterization of the molecular interaction between tropoelastin and DANCE/fibulin-5. Wachi H, Nonaka R, Sato F, Shibata-Sato K, Ishida M, Iketani S, Maeda I, Okamoto K, Urban Z, Onoue S, Seyama Y Journal of biochemistry 143(5) 633-639 2008年5月 21. Distinct steps of cross-linking, self-association, and maturation of tropoelastin are necessary for elastic fiber formation. Sato F, Wachi H, Ishida M, Nonaka R, Onoue S, Urban Z, Starcher BC, Seyama Y Journal of molecular biology 369(3) 841-851 2007年6月 22. Domains 16 and 17 of tropoelastin in elastic fibre formation. Wachi H, Sato F, Nakazawa J, Nonaka R, Szabo Z, Urban Z, Yasunaga T, Maeda I, Okamoto K, Starcher BC, Li DY, Mecham RP, Seyama Y The Biochemical journal 402(1) 63-70 2007年2月

研究テーマ

細胞外マトリックスに着目した細胞機能解析、iPS細胞を用いた神経変性疾患の解析

研究業績（論文）

1.Long-Read Sequencing Resolves a Complex Structural Variant in PRKN Parkinson's Disease.
Kensuke Daida Manabu Funayama Kimberley J Billingsley Laksh Malik Abigail Miano-Burkhardt Hampton L Leonard Mary B Makarious Hirotaka Iwaki Jinhui Ding J Raphael Gibbs Mayu Ishiguro Hiroyo Yoshino Kotaro Ogaki Genko Oyama Kenya Nishioka Risa Nonaka Wado Akamatsu Cornelis Blauwendraat Nobutaka Hattori
Movement disorders 38(12):2249-2257 2023年12月

2. A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease.
Ryota Nakamura, Risa Nonaka, Genko Oyama, Takayuki Jo, Hikaru Kamo, Maierdanjiang Nuermaimaiti, Wado Akamatsu, Kei-Ichi Ishikawa, Nobutaka Hattori
Frontiers in neuroscience 17 1202027-1202027 2023年

3. Increased Risk of Aortic Dissection with Perlecan Deficiency.
Risa Nonaka, Takafumi Iesaki, Aurelien Kerever, Eri Arikawa-Hirasawa
International journal of molecular sciences 23(1) 2021年12月28日

4. Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells.
Kei-Ichi Ishikawa, Risa Nonaka, Wado Akamatsu
Methods in molecular biology (Clifton, N.J.) 2322 73-80 2021年

5. Mutations in CHCHD2 cause α-synuclein aggregation.
Ikeda A, Nishioka K, Meng H, Takanashi M, Hasegawa I, Inoshita T, Shiba-Fukushima K, Li Y, Yoshino H, Mori A, Okuzumi A, Yamaguchi A, Nonaka R, Izawa N, Ishikawa K-I, Saiki H, Morita M, Hasegawa M, Hasegawa K, Elahi M, Funayama M, Okano H, Akamatsu W, Imai Y, Hattori, N
Human Molecular Genetics, 28 (23), pp. 3895-3911. 2019年10月

6. NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.
Furuya N, Kakuta S, Sumiyoshi K, Ando M, Nonaka R, Suzuki A, Kazuno S, Saiki S, Hattori N
EMBO Reports, 19 (12), art. no. e46363 2018年10月

7. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.
Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K
Proceedings of the National Academy of Sciences of the United States of America 115(25) E5815-E5823 2018年6月

8. Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche.
Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E
Journal of neurochemistry 142(4) 534-544 2017年8月

9. Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.
Sadatsuki R, Kaneko H, Kinoshita M, Futami I, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 35(4) 837-846 2017年4月

10. Identification of peptides derived from the C-terminal domain of fibulin-7 active for endothelial cell adhesion and tube formation disruption.
de Vega S, Hozumi K, Suzuki N, Nonaka R, Seo E, Takeda A, Ikeuchi T, Nomizu M, Yamada Y, Arikawa-Hirasawa E
Biopolymers 106(2) 184-195 2016年3月

11. Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle.
Ning L, Xu Z, Furuya N, Nonaka R, Yamada Y, Arikawa-Hirasawa E
Matrix biology : journal of the International Society for Matrix Biology 48 26-35 2015年10月

12. A missense mutation in domain III in HSPG2 in Schwartz-Jampel syndrome compromises secretion of perlecan into the extracellular space.
Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K
Neuromuscular disorders : NMD 25(8) 667-671 2015年8月

13. Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase.
Nonaka R, Iesaki T, de Vega S, Daida H, Okada T, Sasaki T, Arikawa-Hirasawa E
Physiological reports 3(1) 2015年1月

14. Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGF-β pathway.
Ning L, Kurihara H, de Vega S, Ichikawa-Tomikawa N, Xu Z, Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-Hirasawa E
The American journal of pathology 184(6) 1683-1694 2014年6月

15. Perlecan is required for FGF-2 signaling in the neural stem cell niche.
Kerever A, Mercier F, Nonaka R, de Vega S, Oda Y, Zalc B, Okada Y, Hattori N, Yamada Y, Arikawa-Hirasawa E
Stem cell research 12(2) 492-505 2014年3月

16. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture.
de Vega S, Suzuki N, Nonaka R, Sasaki T, Forcinito P, Arikawa-Hirasawa E, Yamada Y
Archives of biochemistry and biophysics 545 148-153 2014年3月

17. Domain 36 of tropoelastin in elastic fiber formation.
Nonaka R, Sato F, Wachi H
Biological & pharmaceutical bulletin 37(4) 698-702 2014年

18. Involvement of reactive oxygen species in abnormal tropoelastin deposition induced by UVA-photosensitizers
Satoshi Onoue, Risa Nonaka, Fumiaki Sato, Chiharu Koide, Akinobu Hayashi, Hiroshi Wachi
Journal of Health Science 55 946-951 2009年12月

19. DANCE/fibulin-5 promotes elastic fiber formation in a tropoelastin isoform-dependent manner.
Nonaka R, Onoue S, Wachi H, Sato F, Urban Z, Starcher BC, Seyama Y
Clinical biochemistry 42(7-8) 713-721 2009年5月

20. Characterization of the molecular interaction between tropoelastin and DANCE/fibulin-5.
Wachi H, Nonaka R, Sato F, Shibata-Sato K, Ishida M, Iketani S, Maeda I, Okamoto K, Urban Z, Onoue S, Seyama Y
Journal of biochemistry 143(5) 633-639 2008年5月

21. Distinct steps of cross-linking, self-association, and maturation of tropoelastin are necessary for elastic fiber formation.
Sato F, Wachi H, Ishida M, Nonaka R, Onoue S, Urban Z, Starcher BC, Seyama Y
Journal of molecular biology 369(3) 841-851 2007年6月

22. Domains 16 and 17 of tropoelastin in elastic fibre formation.
Wachi H, Sato F, Nakazawa J, Nonaka R, Szabo Z, Urban Z, Yasunaga T, Maeda I, Okamoto K, Starcher BC, Li DY, Mecham RP, Seyama Y
The Biochemical journal 402(1) 63-70 2007年2月

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研究業績詳細

野中 里紗（ノナカ リサ）

野中里紗（ノナカリサ）