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根岸尚子（ネギシナオコ）

研究テーマ	T細胞の抗原特異的トレランス誘導機構の解明
研究業績（論文）	Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy. Risa Yamamoto Kumi Izawa Tomoaki Ando Ayako Kaitani Atsushi Tanabe Hiromichi Yamada Shino Uchida Akihisa Yoshikawa Yasuharu Kume Shun Toriumi Akie Maehara Hexing Wang Masakazu Nagamine Naoko Negishi Nobuhiro Nakano Nobuyuki Ebihara Toshiaki Shimizu Hideoki Ogawa Ko Okumura Jiro Kitaura. Frontiers in immunology 14:1238297. 2023 Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium. Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K. Front Immunol. 2022 Mar 17;13:852427. doi: 10.3389/fimmu.2022.852427. eCollection 2022. PMID: 35371023 Anti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model. Zhu J, Inomata T, Nakamura M, Fujimoto K, Akasaki Y, Fujio K, Yanagawa A, Uchida K, Sung J, Negishi N, Nagino K, Okumura Y, Miura M, Shokirova H, Kuwahara M, Hirosawa K, Midorikawa-Inomata A, Eguchi A, Huang T, Yagita H, Habu S, Okumura K, Murakami A. Sci Rep. 2022 Mar 22;12(1):4853. doi: 10.1038/s41598-022-08949-9. PMID: 35318419 Ex Vivo-Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice. Zhu J, Inomata T, Fujimoto K, Uchida K, Fujio K, Nagino K, Miura M, Negishi N, Okumura Y, Akasaki Y, Hirosawa K, Kuwahara M, Eguchi A, Shokirova H, Yanagawa A, Midorikawa-Inomata A, Murakami A. Invest Ophthalmol Vis Sci. 2021 Jun 1;62(7):3. doi: 10.1167/iovs.62.7.3. PMID: 34061951 Novel immunotherapeutic effects of topically administered ripasudil (K-115) on corneal allograft survival. Inomata T, Fujimoto K, Okumura Y, Zhu J, Fujio K, Shokirova H, Miura M, Okano M, Funaki T, Sung J, Negishi N, Murakami A. Sci Rep. 2020 Nov 13;10(1):19817. doi: 10.1038/s41598-020-76882-w. PMID: 33188243 CD300f is a potential therapeutic target for the treatment of food allergy. Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J. Allergy. 2020 Feb;75(2):471-474. doi: 10.1111/all.14034. Epub 2019 Oct 2. CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity Naoko Negishi, Takehito Sato, Yumi Yamashita-Kanemaru, Kazuko Shibuya, Koichiro Uchida, Yoshie Kametani, Hideo Yagita, Jiro Kitaura, Ko Okumura and Sonoko Habu ImmunoHorizons 2(10) 338-348 2018.11 Delta-like 4-mediated Notch signaling is required for early T-cell development in a three-dimensional thymic structure. Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K European journal of immunology 45(8) 2252-2262 2015年8月 Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates. Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H Stem cells translational medicine 4(7) 708-719 2015年7月 Disappearance of centroacinar cells in the Notch ligand-deficient pancreas. Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K Genes to cells : devoted to molecular & cellular mechanisms 20(6) 500-511 2015年6月 Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1. Negishi N, Suzuki D, Ito R, Irie N, Matsuo K, Yahata T, Nagano K, Aoki K, Ohya K, Hozumi K, Ando K, Tamaoki N, Ito M, Habu S Experimental hematology 42(6) 487-94.e1 2014年6月 Commensal bacteria regulate thymic Aire expression. Nakajima A, Negishi N, Tsurui H, Kadowaki-Ohtsuji N, Maeda K, Nanno M, Yamaguchi Y, Shimizu N, Yagita H, Okumura K, Habu S PloS one 9(8) e105904 2014年 Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts. Ito R, Negishi N, Irie N, Matsuo K, Suzuki D, Katano I, Hayakawa E, Kawai K, Kamisako T, Eto T, Ogura T, Hozumi K, Ando K, Aiso S, Tamaoki N, Habu S, Ito M Experimental hematology 40(11) 953-963.e3 2012年11月

研究テーマ

T細胞の抗原特異的トレランス誘導機構の解明

研究業績（論文）

Murine model identifies tropomyosin as IgE cross-reactive protein between house dust mite and coho salmon that possibly contributes to the development of salmon allergy.
Risa Yamamoto Kumi Izawa Tomoaki Ando Ayako Kaitani Atsushi Tanabe Hiromichi Yamada Shino Uchida Akihisa Yoshikawa Yasuharu Kume Shun Toriumi Akie Maehara Hexing Wang Masakazu Nagamine Naoko Negishi Nobuhiro Nakano Nobuyuki Ebihara Toshiaki Shimizu Hideoki Ogawa Ko Okumura Jiro Kitaura. Frontiers in immunology 14:1238297. 2023

Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.
Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K.
Front Immunol. 2022 Mar 17;13:852427. doi: 10.3389/fimmu.2022.852427. eCollection 2022.
PMID: 35371023

Anti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model.
Zhu J, Inomata T, Nakamura M, Fujimoto K, Akasaki Y, Fujio K, Yanagawa A, Uchida K, Sung J, Negishi N, Nagino K, Okumura Y, Miura M, Shokirova H, Kuwahara M, Hirosawa K, Midorikawa-Inomata A, Eguchi A, Huang T, Yagita H, Habu S, Okumura K, Murakami A.
Sci Rep. 2022 Mar 22;12(1):4853. doi: 10.1038/s41598-022-08949-9.
PMID: 35318419

Ex Vivo-Induced Bone Marrow-Derived Myeloid Suppressor Cells Prevent Corneal Allograft Rejection in Mice.
Zhu J, Inomata T, Fujimoto K, Uchida K, Fujio K, Nagino K, Miura M, Negishi N, Okumura Y, Akasaki Y, Hirosawa K, Kuwahara M, Eguchi A, Shokirova H, Yanagawa A, Midorikawa-Inomata A, Murakami A.
Invest Ophthalmol Vis Sci. 2021 Jun 1;62(7):3. doi: 10.1167/iovs.62.7.3.
PMID: 34061951

Novel immunotherapeutic effects of topically administered ripasudil (K-115) on corneal allograft survival.
Inomata T, Fujimoto K, Okumura Y, Zhu J, Fujio K, Shokirova H, Miura M, Okano M, Funaki T, Sung J, Negishi N, Murakami A.
Sci Rep. 2020 Nov 13;10(1):19817. doi: 10.1038/s41598-020-76882-w.
PMID: 33188243

CD300f is a potential therapeutic target for the treatment of food allergy.
Uchida S, Izawa K, Ando T, Yamada H, Uchida K, Negishi N, Kaitani A, Maehara A, Nagamine M, Kamei A, Takamori A, Maeda K, Nakano N, Shimizu T, Ogawa H, Okumura K, Nagahara A, Watanabe S, Kitaura J.
Allergy. 2020 Feb;75(2):471-474. doi: 10.1111/all.14034. Epub 2019 Oct 2.

CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity
Naoko Negishi, Takehito Sato, Yumi Yamashita-Kanemaru, Kazuko Shibuya, Koichiro Uchida, Yoshie Kametani, Hideo Yagita, Jiro Kitaura, Ko Okumura and Sonoko Habu
ImmunoHorizons 2(10) 338-348 2018.11

Delta-like 4-mediated Notch signaling is required for early T-cell development in a three-dimensional thymic structure.
Hirano K, Negishi N, Yazawa M, Yagita H, Habu S, Hozumi K
European journal of immunology 45(8) 2252-2262 2015年8月

Allogeneic Neural Stem/Progenitor Cells Derived From Embryonic Stem Cells Promote Functional Recovery After Transplantation Into Injured Spinal Cord of Nonhuman Primates.
Iwai H, Shimada H, Nishimura S, Kobayashi Y, Itakura G, Hori K, Hikishima K, Ebise H, Negishi N, Shibata S, Habu S, Toyama Y, Nakamura M, Okano H
Stem cells translational medicine 4(7) 708-719 2015年7月

Disappearance of centroacinar cells in the Notch ligand-deficient pancreas.
Nakano Y, Negishi N, Gocho S, Mine T, Sakurai Y, Yazawa M, Abe K, Yagita H, Habu S, Kageyama R, Kawaguchi Y, Hozumi K
Genes to cells : devoted to molecular & cellular mechanisms 20(6) 500-511 2015年6月

Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged1.
Negishi N, Suzuki D, Ito R, Irie N, Matsuo K, Yahata T, Nagano K, Aoki K, Ohya K, Hozumi K, Ando K, Tamaoki N, Ito M, Habu S
Experimental hematology 42(6) 487-94.e1 2014年6月

Commensal bacteria regulate thymic Aire expression.
Nakajima A, Negishi N, Tsurui H, Kadowaki-Ohtsuji N, Maeda K, Nanno M, Yamaguchi Y, Shimizu N, Yagita H, Okumura K, Habu S
PloS one 9(8) e105904 2014年

Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts.
Ito R, Negishi N, Irie N, Matsuo K, Suzuki D, Katano I, Hayakawa E, Kawai K, Kamisako T, Eto T, Ogura T, Hozumi K, Ando K, Aiso S, Tamaoki N, Habu S, Ito M
Experimental hematology 40(11) 953-963.e3 2012年11月

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根岸 尚子（ネギシ ナオコ）

根岸尚子（ネギシナオコ）