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研究業績詳細

Kerever Aurelien（ケレベールオレリアン）

研究テーマ	細胞外マトリックスと幹細胞生物学・老化研究
研究業績（論文）	Tanaka, T., Kerever, A., Suzuki, Y., Kunitomi, T., Kato, K., Yamashita, Y., Higashi, K., Akazawa, C., Saitow, F., Suzuki, H., Arikawa-Hirasawa, E. GPR17+ Oligodendrocyte Lineage Cells Regulate the Critical Period of Brain Development Through Novel Chondroitin Sulfate-Rich Structures. Glia 74, e70188 (2026). Nishimura, H., Kerever, A., Kato, K., Ono, T., Nakayama, S., Tanaka, T., Abe, R., Arikawa-Hirasawa, E. Oligodendrocyte differentiation on murine decellularized brain tissue. Neuroscience Letters 846, 138079 (2025). Egorova, D., Kerever, A., Inada, M., Itoh, Y., Arikawa-Hirasawa, E., Miyata, S. Microglial depletion increases aggrecan and hyaluronan levels in the diffuse and aggregated extracellular matrix of the mouse brain. Scientific Reports 15, 9376 (2025). Yamada, H., Makino, S., Okunaga, I., Miyake, T., Yamamoto-Nonaka, K., Oliva Trejo, J.A., Tominaga, T., Empitu, M.A., Kadariswantiningsih, I.N., Kerever, A., Komiya, A., Ichikawa, T., Arikawa-Hirasawa, E., Yanagita, M., Asanuma, K. Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue. PNAS Nexus 3, pgad433 (2023). Kato, K., Nishimura, H., Suzuki, Y., Tanaka, T., Abe, R., Kerever, A., Arikawa-Hirasawa, E. Oligodendrocyte Cell Line OLP6 Successfully Differentiates on Decellularized Brain Tissue. Juntendo Medical Journal 69, 300–306 (2023). Tsuji, Y., Kerever, A., Furukawa, T., Kamagata, K., Saito, Y., Aoki, S., Hata, J., Okano, H., Kobayashi, K., Okada, T., Miya, K., Keino-Masu, K., Masu, M., Arikawa-Hirasawa, E. Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain. Magnetic Resonance Imaging 88, 123–131 (2022). Hayashiji, N., Kawahara, G., Xu, X., Fukuda, T., Kerever, A., Gu, J., Hayashi, Y.K., Arikawa-Hirasawa, E. α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish. Cells 12, 144 (2022). Nonaka, R., Iesaki, T., Kerever, A., Arikawa-Hirasawa, E. Increased Risk of Aortic Dissection with Perlecan Deficiency. International Journal of Molecular Sciences 23, 315 (2021). Kerever, A., Nagahara, F., Keino-Masu, K., Masu, M., van Kuppevelt, T.H., Vivès, R.R., Arikawa-Hirasawa, E. Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches. Glycobiology 31, 1531–1542 (2021). Kerever, A., Arikawa-Hirasawa, E. Optimal Extracellular Matrix Niches for Neurogenesis: Identifying Glycosaminoglycan Chain Composition in the Subventricular Neurogenic Zone. Frontiers in Neuroanatomy 15, 764458 (2021). Suzuki, Y., Kerever, A., Tanaka, T., Higashi, K., Arikawa-Hirasawa, E. The Structural and Compositional Changes of Chondroitin Sulfate Chains in the Aged Mouse Hippocampus. Juntendo Medical Journal 65, 64–70 (2019). Tanaka, H., Kondo, K., Chen, X., Homma, H., Tagawa, K., Kerever, A., Aoki, S., Saito, T., Saido, T., Muramatsu, S.-I., Fujita, K., Okazawa, H. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Molecular Psychiatry 23, 2029–2039 (2018). Irie, R., Kamagata, K., Kerever, A., Ueda, R., Yokosawa, S., Otake, Y., Ochi, H., Yoshizawa, H., Hayashi, A., Tagawa, K., Okazawa, H., Takahashi, K., Sato, K., Hori, M., Arikawa-Hirasawa, E., Aoki, S. The relationship between neurite density measured with confocal microscopy in a cleared mouse brain and metrics obtained from diffusion tensor and diffusion kurtosis imaging. Magnetic Resonance in Medical Sciences 17, 138–144 (2018). Yamada, T., Kerever, A., Yoshimura, Y., Suzuki, Y., Nonaka, R., Higashi, K., Toida, T., Mercier, F., Arikawa-Hirasawa, E. Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche. Journal of Neurochemistry 142, 534–544 (2017). Sato, K., Kerever, A., Kamagata, K., Tsuruta, K., Irie, R., Tagawa, K., Okazawa, H., Arikawa-Hirasawa, E., Nitta, N., Aoki, I., Aoki, S. Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain. Acta Radiologica Open 6, 2058460117703816 (2017). Kamagata, K., Kerever, A., Yokosawa, S., Otake, Y., Ochi, H., Hori, M., Kamiya, K., Tsuruta, K., Tagawa, K., Okazawa, H., Aoki, S., Arikawa-Hirasawa, E. Quantitative histological validation of diffusion tensor MRI with two-photon microscopy of cleared mouse brain. Magnetic Resonance in Medical Sciences 15, 416–421 (2016). Kerever, A., Yamada, T., Suzuki, Y., Mercier, F., Arikawa-Hirasawa, E. Fractone aging in the subventricular zone of the lateral ventricle. Journal of Chemical Neuroanatomy 66–67, 52–60 (2015). Kerever, A., Kamagata, K., Yokosawa, S., Otake, Y., Ochi, H., Yamada, T., Hori, M., Kamiya, K., Nishikori, A., Aoki, S., Arikawa-Hirasawa, E. See-through brains and diffusion tensor MRI clarified fiber connections: A preliminary microstructural study in a mouse with callosal agenesis. Magnetic Resonance in Medical Sciences 14, 159–162 (2015). Kerever, A., Mercier, F., Nonaka, R., de Vega, S., Oda, Y., Zalc, B., Okada, Y., Hattori, N., Yamada, Y., Arikawa-Hirasawa, E. Perlecan is required for FGF-2 signaling in the neural stem cell niche. Stem Cell Research 12, 492–505 (2014). Douet, V., Kerever, A., Arikawa-Hirasawa, E., Mercier, F. Fractone-heparan sulphates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone. Cell Proliferation 46, 137–145 (2013). Miguez, A., Ducret, S., Di Meglio, T., Parras, C., Hmidan, H., Haton, C., Sekizar, S., Mannioui, A., Vidal, M., Kerever, A., Nyabi, O., Haigh, J., Zalc, B., Rijli, F.M., Thomas, J.-L. Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning. Journal of Neuroscience 32, 17172–17185 (2012). Kerever, A., Schnack, J., Vellinga, D., Ichikawa, N., Moon, C., Arikawa-Hirasawa, E., Efird, J.T., Mercier, F. Novel Extracellular Matrix Structures in the Neural Stem Cell Niche Capture the Neurogenic Factor Fibroblast Growth Factor 2 from the Extracellular Milieu. STEM CELLS 25, 2146–2157 (2007).

研究テーマ

細胞外マトリックスと幹細胞生物学・老化研究

研究業績（論文）

Tanaka, T., Kerever, A., Suzuki, Y., Kunitomi, T., Kato, K., Yamashita, Y., Higashi, K., Akazawa, C., Saitow, F., Suzuki, H., Arikawa-Hirasawa, E. GPR17+ Oligodendrocyte Lineage Cells Regulate the Critical Period of Brain Development Through Novel Chondroitin Sulfate-Rich Structures. Glia 74, e70188 (2026).

Nishimura, H., Kerever, A., Kato, K., Ono, T., Nakayama, S., Tanaka, T., Abe, R., Arikawa-Hirasawa, E. Oligodendrocyte differentiation on murine decellularized brain tissue. Neuroscience Letters 846, 138079 (2025).

Egorova, D., Kerever, A., Inada, M., Itoh, Y., Arikawa-Hirasawa, E., Miyata, S. Microglial depletion increases aggrecan and hyaluronan levels in the diffuse and aggregated extracellular matrix of the mouse brain. Scientific Reports 15, 9376 (2025).

Yamada, H., Makino, S., Okunaga, I., Miyake, T., Yamamoto-Nonaka, K., Oliva Trejo, J.A., Tominaga, T., Empitu, M.A., Kadariswantiningsih, I.N., Kerever, A., Komiya, A., Ichikawa, T., Arikawa-Hirasawa, E., Yanagita, M., Asanuma, K. Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue. PNAS Nexus 3, pgad433 (2023).

Kato, K., Nishimura, H., Suzuki, Y., Tanaka, T., Abe, R., Kerever, A., Arikawa-Hirasawa, E. Oligodendrocyte Cell Line OLP6 Successfully Differentiates on Decellularized Brain Tissue. Juntendo Medical Journal 69, 300–306 (2023).

Tsuji, Y., Kerever, A., Furukawa, T., Kamagata, K., Saito, Y., Aoki, S., Hata, J., Okano, H., Kobayashi, K., Okada, T., Miya, K., Keino-Masu, K., Masu, M., Arikawa-Hirasawa, E. Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain. Magnetic Resonance Imaging 88, 123–131 (2022).

Hayashiji, N., Kawahara, G., Xu, X., Fukuda, T., Kerever, A., Gu, J., Hayashi, Y.K., Arikawa-Hirasawa, E. α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish. Cells 12, 144 (2022).

Nonaka, R., Iesaki, T., Kerever, A., Arikawa-Hirasawa, E. Increased Risk of Aortic Dissection with Perlecan Deficiency. International Journal of Molecular Sciences 23, 315 (2021).

Kerever, A., Nagahara, F., Keino-Masu, K., Masu, M., van Kuppevelt, T.H., Vivès, R.R., Arikawa-Hirasawa, E. Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches. Glycobiology 31, 1531–1542 (2021).

Kerever, A., Arikawa-Hirasawa, E. Optimal Extracellular Matrix Niches for Neurogenesis: Identifying Glycosaminoglycan Chain Composition in the Subventricular Neurogenic Zone. Frontiers in Neuroanatomy 15, 764458 (2021).

Suzuki, Y., Kerever, A., Tanaka, T., Higashi, K., Arikawa-Hirasawa, E. The Structural and Compositional Changes of Chondroitin Sulfate Chains in the Aged Mouse Hippocampus. Juntendo Medical Journal 65, 64–70 (2019).

Tanaka, H., Kondo, K., Chen, X., Homma, H., Tagawa, K., Kerever, A., Aoki, S., Saito, T., Saido, T., Muramatsu, S.-I., Fujita, K., Okazawa, H. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. Molecular Psychiatry 23, 2029–2039 (2018).

Irie, R., Kamagata, K., Kerever, A., Ueda, R., Yokosawa, S., Otake, Y., Ochi, H., Yoshizawa, H., Hayashi, A., Tagawa, K., Okazawa, H., Takahashi, K., Sato, K., Hori, M., Arikawa-Hirasawa, E., Aoki, S. The relationship between neurite density measured with confocal microscopy in a cleared mouse brain and metrics obtained from diffusion tensor and diffusion kurtosis imaging. Magnetic Resonance in Medical Sciences 17, 138–144 (2018).

Yamada, T., Kerever, A., Yoshimura, Y., Suzuki, Y., Nonaka, R., Higashi, K., Toida, T., Mercier, F., Arikawa-Hirasawa, E. Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche. Journal of Neurochemistry 142, 534–544 (2017).

Sato, K., Kerever, A., Kamagata, K., Tsuruta, K., Irie, R., Tagawa, K., Okazawa, H., Arikawa-Hirasawa, E., Nitta, N., Aoki, I., Aoki, S. Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain. Acta Radiologica Open 6, 2058460117703816 (2017).

Kamagata, K., Kerever, A., Yokosawa, S., Otake, Y., Ochi, H., Hori, M., Kamiya, K., Tsuruta, K., Tagawa, K., Okazawa, H., Aoki, S., Arikawa-Hirasawa, E. Quantitative histological validation of diffusion tensor MRI with two-photon microscopy of cleared mouse brain. Magnetic Resonance in Medical Sciences 15, 416–421 (2016).

Kerever, A., Yamada, T., Suzuki, Y., Mercier, F., Arikawa-Hirasawa, E. Fractone aging in the subventricular zone of the lateral ventricle. Journal of Chemical Neuroanatomy 66–67, 52–60 (2015).

Kerever, A., Kamagata, K., Yokosawa, S., Otake, Y., Ochi, H., Yamada, T., Hori, M., Kamiya, K., Nishikori, A., Aoki, S., Arikawa-Hirasawa, E. See-through brains and diffusion tensor MRI clarified fiber connections: A preliminary microstructural study in a mouse with callosal agenesis. Magnetic Resonance in Medical Sciences 14, 159–162 (2015).

Kerever, A., Mercier, F., Nonaka, R., de Vega, S., Oda, Y., Zalc, B., Okada, Y., Hattori, N., Yamada, Y., Arikawa-Hirasawa, E. Perlecan is required for FGF-2 signaling in the neural stem cell niche. Stem Cell Research 12, 492–505 (2014).

Douet, V., Kerever, A., Arikawa-Hirasawa, E., Mercier, F. Fractone-heparan sulphates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone. Cell Proliferation 46, 137–145 (2013).

Miguez, A., Ducret, S., Di Meglio, T., Parras, C., Hmidan, H., Haton, C., Sekizar, S., Mannioui, A., Vidal, M., Kerever, A., Nyabi, O., Haigh, J., Zalc, B., Rijli, F.M., Thomas, J.-L. Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning. Journal of Neuroscience 32, 17172–17185 (2012).

Kerever, A., Schnack, J., Vellinga, D., Ichikawa, N., Moon, C., Arikawa-Hirasawa, E., Efird, J.T., Mercier, F. Novel Extracellular Matrix Structures in the Neural Stem Cell Niche Capture the Neurogenic Factor Fibroblast Growth Factor 2 from the Extracellular Milieu. STEM CELLS 25, 2146–2157 (2007).

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【学校法人順天堂】研究者情報データベース

研究業績詳細

Kerever Aurelien（ケレベール オレリアン）

Kerever Aurelien（ケレベールオレリアン）