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李賢哲（リケンテツ）

研究テーマ	脂質の生理的意義の解明
研究業績（論文）	37. Ito D, Iida M, Iguchi Y, Hashizume A, Yamada S, Kishimoto Y, Komori S, Obara K, Nishisaki S, Yokoi S, Shimamura T, Takemoto Y, Nakatochi M, Akashi T, Hinohara K, Lee-Okada HC, Okada Y, Niwa J, Sobue G, Tanaka S, Takashina K, Yokomizo T, Katsuno M. Fatty acid amide hydrolase inhibition for treatment of amyotrophic lateral sclerosis. JCI Insight, 2026, 11, e198842. doi: 10.1172/jci.insight.198842 36. Yanai S, Sasaki J, Lee-Okada HC, Takahashi F, Kikuchi Y, Morioka S, Yamamoto T, Yuguchi K, Oikawa M, Kajiho H, Baba T, Yokoyama C, Morohashi KI, Suzuki A, Yokomizo T, Sasaki T. Adrenal lipoma formation via PI(3,4,5)P3/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes. Proc Natl Acad Sci U S A, 2025, 122, e2510306122. doi: 10.1073/pnas.2510306122. 35. Ishii Y, Makita K, Fujii U, Nakada E, Jang J, McGovern T, Sun R, Morozan A, Joy S, Dunberry S, Okuno T, Lee-Okada HC, Yokomizo T, Martin JG. Leukotriene C4 Synthase Deficiency Causes Spontaneous Emphysema in Female Mice. Am J Respir Cell Mol Biol, 2026, 74, 27-39. doi: 10.1165/rcmb.2024-0260OC. 34. Sakai R, Aizawa S, Lee-Okada HC, Hase K, Fujita H, Kikuchi H, Inoue YU, Inoue T, Kabuta C, Yokomizo T, Hashimoto T, Wada K, Mano T, Koyama-Honda I, Kabuta T. The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders. Cell Rep, 2025, 44, 115829. doi: 10.1016/j.celrep.2025.115829. 33. Ando M, Lee-Okada HC, Yokomizo T. Molecular Mechanisms by Which Polyunsaturated Fatty Acids Suppress the Pathogenesis and Progression of NAFLD. Yakugaku Zasshi, 2025, 145, 177-182 (Review) doi: 10.1248/yakushi.24-00177-2. 32. Lee-Okada HC, Xue C, Yokomizo T. Recent advances on the physiological and pathophysiological roles of polyunsaturated fatty acids and their biosynthetic pathway. Biochim Biophys Acta Mol Cell Biol Lipids, 2025, 1870, 159564 (Review, Correspondence) doi: 10.1016/j.bbalip.2024.159564 31. Takahashi F, Baba T, Christianto A, Yanai S, Lee-Okada HC, Ishiwata K, Nakabayashi K, Hata K, Ishii T, Hasegawa T, Yokomizo T, Choi MH, Morohashi KI. Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression. Cell Rep, 2024, 43, 113715. doi: 10.1016/j.celrep.2024.113715. 30. Jonnalagadda D, Kihara Y, Groves A, Ray M, Saha A, Ellington C, Lee-Okada HC, Furihata T, Yokomizo T, Quadros EV, Rivera R, Chun J. FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis. Cell Rep, 2023, 42, 113545. doi: 10.1016/j.celrep.2023.113545. 29. Ishida Y, Saeki K, Ueda M, Lee-Okada HC, Doi H, Kambe N, Nakajima S, Yokomizo T, Kabashima K. CYP4F22 p.V215D is a novel variant causative for lamellar ichthyosis. J Eur Acad Dermatol Venereol, 2024, 38, e493-e495. doi: 10.1111/jdv.19680. 28. Yamamoto H, Lee-Okada HC, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T, Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Mol Psychiatry, 2023, 28, 2848-2856. doi: 10.1038/s41380-023-01988-2 27. Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun, 2022, 13, 7857. doi: 10.1038/s41467-022-35501-0. 26. Ri K, Lee-Okada HC, Yokomizo T. Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production. Commun Biol, 2022, 5, 1001. (Correspondence) doi: 10.1038/s42003-022-03972-y. 25. Tan KJ, Nakamizo S, Lee-Okada HC, Sato R, Chow Z, Nakajima S, Common JEA, Saeki K, Yokomizo T, Ginhoux F, Kabashima K. A western diet alters skin ceramides and compromises the skin barrier in ears. J Invest Dermatol, 2022, 142, 2020-2023. doi: 10.1016/j.jid.2021.12.017. 24. Shioda R, Jo-Watanabe A, Lee-Okada HC, Yasukawa K, Okuno T, Suzuki Y, Yokomizo T. Dietary intake of n-3 polyunsaturated fatty acids alters the lipid mediator profile of the kidney but does not attenuate renal insufficiency. Biochem Biophys Res Commun, 2021, 582, 49-56. doi: 10.1016/j.bbrc.2021.10.028. 23. Hayashi Y, Lee‐Okada HC, Nakamura E, Tada N, Yokomizo T, Fujiwara Y, Ichi I. FADS2 ablation exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice. FEBS Lett, 2021, 595, 1920-1932. doi: 10.1002/1873-3468.14134 22. Lee‐Okada HC, Hama K, Yokoyama K, Yokomizo T. Development of a liquid chromatography–electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids. J Biochem, 2021, 170, 389-397. (Correspondence) https://doi.org/10.1093/jb/mvab054 21. Han B, Lee‐Okada HC, Ishimine M, Orita H, Nishikawa K, Takagaki T, Kajino K, Yokomizo T, Hino O, Kobayashi T. Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells. FEBS Open Bio, 2020, 10, 2375-2387. (Correspondence, Co-first) https://doi.org/10.1002/2211-5463.12985 20. Ishimine M, Yokomizo T, Lee-Okada HC. Carboxylesterase 2: A Key Enzyme in Drug and Prodrug Metabolism. Juntendo Med J, 2020, 66, 120-124. (Review, Correspondence) http://doi.org/10.14789/jmj.2020.66.JMJ19-R18 19. Ishizuka K, Kon K, Lee-Okada HC, Arai K, Uchiyama A, Yamashina S, Yokomizo T, Ikejima K. Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice, J Gastroenterol Hepatol, 2020, 35, 1437-1448. doi: 10.1111/jgh.15006. PMID: 32030821 18. Kaji S, Irino T, Kusuhara M, Makuuchi R, Yamakawa Y, Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Kami K, Ohashi Y, Zhang S, Orita H, Lee-Okada HC, Fukunaga T, Terashima M. Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence. Gastric Cancer. 2020, 23, 874-883. doi: 10.1007/s10120-020-01065-5. PMID: 32219586 17. Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life Sci Alliance, 2019, 3, e201900513. doi: 10.26508/lsa.201900513. PMID: 31879337 16. Fujihira H, Masahara-Negishi Y, Akimoto Y, Hirayama H, Lee HC, Story BA, Mueller WF, Jakob P, Clauder-Münster S, Steinmetz LM, Radhakrishnan SK, Kawakami H, Kamada Y, Miyoshi E, Yokomizo T, Suzuki T. Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress. Biochim Biophys Acta Mol Basis Dis, 2020, 1866, 165588. doi: 10.1016/j.bbadis.2019.165588. PMID: 31733337 15. Zhang S, Kohira Y, Orita H, Ishimine M, Kobayashi T, Buendia Chua SM, Nakaoka H, Inoue I, Hino O, Yokomizo T, Fukunaga T, Lee-Okada HC. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation. BPB Reports, 2019, 2, 130-133. (Correspondence) doi: 10.1248/bpbreports.2.6_130 https://www3.e-kenkyu.com/bpb-reports-online-journal/papers/29?number=6&volume=2&year=2019 14. Lee HC, Tominaga M, Yasukawa K, Ohba M, Takahashi N, Honda K, Okuno T, Takamori K, Yokomizo T. Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis. J Dermatol Sci, 2019, 95, 130-133. (Correspondence) doi: 10.1016/j.jdermsci.2019.07.010. PMID: 31383390 13. Shin M, Ware TB, Lee HC, Hsu KL. Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond. Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864, 907-921. (Review, Correspondence) doi: 10.1016/j.bbalip.2018.08.007 PMID: 30905349 12. Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat Commun, 2019, 10, 1567. doi: 10.1038/s41467-019-08829-3. PMID: 30952864 11. Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, Murakami A, Matsuda A, Yokomizo T. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses. FASEB J, 2019, 33, 3392-3403. doi: 10.1096/fj.201801805R. PMID: 30383446 10. Lee HC, Yokomizo T. Applications of mass spectrometry-based targeted and non-targeted lipidomics. Biochem Biophys Res Commun, 2018, 504, 576-581. (Review, Correspondence). doi: 10.1016/j.bbrc.2018.03.081. PMID: 29534960 9. Kawanishi N, Takagi K, Lee HC, Nakano D, Okuno T, Yokomizo T, Machida S. Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol, 2018, 314, R892-R901. (Co-first) doi: 10.1152/ajpregu.00371.2017. PMID: 29443549 8. Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer. Dis Markers, 2018, 2018, 5280736. (Correspondence, Co-first) doi: 10.1155/2018/5280736. PMID: 29651325 7. Cognetta AB 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chem Biol, 2015, 22, 928-37. doi: 10.1016/j.chembiol.2015.05.018. PMID: 26120000 6. Lee HC, Simon GM, Cravatt BF. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Biochemistry, 2015, 54, 2539-49. (Correspondence) doi: 10.1021/acs.biochem.5b00207. PMID: 25853435 5. Hirata Y, Yamamori N, Kono N, Lee HC, Inoue T, Arai H. Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein. Genes Cells, 2013, 18, 397-409. doi: 10.1111/gtc.12046. PMID: 23510452 4. Lee HC, Inoue T, Sasaki J, Kubo T, Matsuda S, Nakasaki Y, Hattori M, Tanaka F, Udagawa O, Kono N, Itoh T, Ogiso H, Taguchi R, Arita M, Sasaki T, Arai H. LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol Biol Cell, 2012, 23, 4689-4700. doi: 10.1091/mbc.E12-09-0673. PMID: 23097495 3. Lee HC, Kubo T, Kono N, Kage-Nakadai E, Gengyo-Ando K, Mitani S, Inoue T, Arai H. Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans. Genes Cells, 2012, 17, 748-57. doi: 10.1111/j.1365-2443.2012.01624.x. PMID: 22862955 2. Matsuda S, Inoue T, Lee HC, Kono N, Tanaka F, Gengyo-Ando K, Mitani S, Arai H. Member of the membrane-bound Oacyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity. Genes Cells, 2008, 13, 879-88. doi: 10.1111/j.1365-2443.2008.01212.x. PMID: 18782225 1. Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H. Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Mol Biol Cell, 2008, 19, 1174-84. doi: 10.1091/mbc.e07-09-0893. PMID: 18094042

研究テーマ

脂質の生理的意義の解明

研究業績（論文）

37. Ito D, Iida M, Iguchi Y, Hashizume A, Yamada S, Kishimoto Y, Komori S, Obara K, Nishisaki S, Yokoi S, Shimamura T, Takemoto Y, Nakatochi M, Akashi T, Hinohara K, Lee-Okada HC, Okada Y, Niwa J, Sobue G, Tanaka S, Takashina K, Yokomizo T, Katsuno M. Fatty acid amide hydrolase inhibition for treatment of amyotrophic lateral sclerosis. JCI Insight, 2026, 11, e198842.
doi: 10.1172/jci.insight.198842

36. Yanai S, Sasaki J, Lee-Okada HC, Takahashi F, Kikuchi Y, Morioka S, Yamamoto T, Yuguchi K, Oikawa M, Kajiho H, Baba T, Yokoyama C, Morohashi KI, Suzuki A, Yokomizo T, Sasaki T. Adrenal lipoma formation via PI(3,4,5)P3/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes. Proc Natl Acad Sci U S A, 2025, 122, e2510306122.
doi: 10.1073/pnas.2510306122.

35. Ishii Y, Makita K, Fujii U, Nakada E, Jang J, McGovern T, Sun R, Morozan A, Joy S, Dunberry S, Okuno T, Lee-Okada HC, Yokomizo T, Martin JG. Leukotriene C4 Synthase Deficiency Causes Spontaneous Emphysema in Female Mice. Am J Respir Cell Mol Biol, 2026, 74, 27-39.
doi: 10.1165/rcmb.2024-0260OC.

34. Sakai R, Aizawa S, Lee-Okada HC, Hase K, Fujita H, Kikuchi H, Inoue YU, Inoue T, Kabuta C, Yokomizo T, Hashimoto T, Wada K, Mano T, Koyama-Honda I, Kabuta T. The lysosomal membrane protein LAMP2B mediates microlipophagy to target obesity-related disorders. Cell Rep, 2025, 44, 115829.
doi: 10.1016/j.celrep.2025.115829.

33. Ando M, Lee-Okada HC, Yokomizo T. Molecular Mechanisms by Which Polyunsaturated Fatty Acids Suppress the Pathogenesis and Progression of NAFLD. Yakugaku Zasshi, 2025, 145, 177-182 (Review)
doi: 10.1248/yakushi.24-00177-2.

32. Lee-Okada HC, Xue C, Yokomizo T. Recent advances on the physiological and pathophysiological roles of polyunsaturated fatty acids and their biosynthetic pathway. Biochim Biophys Acta Mol Cell Biol Lipids, 2025, 1870, 159564 (Review, Correspondence)
doi: 10.1016/j.bbalip.2024.159564

31. Takahashi F, Baba T, Christianto A, Yanai S, Lee-Okada HC, Ishiwata K, Nakabayashi K, Hata K, Ishii T, Hasegawa T, Yokomizo T, Choi MH, Morohashi KI. Development of sexual dimorphism of skeletal muscles through the adrenal cortex, caused by androgen-induced global gene suppression. Cell Rep, 2024, 43, 113715.
doi: 10.1016/j.celrep.2024.113715.

30. Jonnalagadda D, Kihara Y, Groves A, Ray M, Saha A, Ellington C, Lee-Okada HC, Furihata T, Yokomizo T, Quadros EV, Rivera R, Chun J. FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis. Cell Rep, 2023, 42, 113545.
doi: 10.1016/j.celrep.2023.113545.

29. Ishida Y, Saeki K, Ueda M, Lee-Okada HC, Doi H, Kambe N, Nakajima S, Yokomizo T, Kabashima K. CYP4F22 p.V215D is a novel variant causative for lamellar ichthyosis. J Eur Acad Dermatol Venereol, 2024, 38, e493-e495.
doi: 10.1111/jdv.19680.

28. Yamamoto H, Lee-Okada HC, Ikeda M, Nakamura T, Saito T, Takata A, Yokomizo T, Iwata N, Kato T, Kasahara T. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Mol Psychiatry, 2023, 28, 2848-2856.
doi: 10.1038/s41380-023-01988-2

27. Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nat Commun, 2022, 13, 7857.
doi: 10.1038/s41467-022-35501-0.

26. Ri K, Lee-Okada HC, Yokomizo T. Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production. Commun Biol, 2022, 5, 1001. (Correspondence)
doi: 10.1038/s42003-022-03972-y.

25. Tan KJ, Nakamizo S, Lee-Okada HC, Sato R, Chow Z, Nakajima S, Common JEA, Saeki K, Yokomizo T, Ginhoux F, Kabashima K. A western diet alters skin ceramides and compromises the skin barrier in ears. J Invest Dermatol, 2022, 142, 2020-2023.
doi: 10.1016/j.jid.2021.12.017.

24. Shioda R, Jo-Watanabe A, Lee-Okada HC, Yasukawa K, Okuno T, Suzuki Y, Yokomizo T. Dietary intake of n-3 polyunsaturated fatty acids alters the lipid mediator profile of the kidney but does not attenuate renal insufficiency. Biochem Biophys Res Commun, 2021, 582, 49-56.
doi: 10.1016/j.bbrc.2021.10.028.

23. Hayashi Y, Lee‐Okada HC, Nakamura E, Tada N, Yokomizo T, Fujiwara Y, Ichi I. FADS2 ablation exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice. FEBS Lett, 2021, 595, 1920-1932.
doi: 10.1002/1873-3468.14134

22. Lee‐Okada HC, Hama K, Yokoyama K, Yokomizo T. Development of a liquid chromatography–electrospray ionization tandem mass spectrometric method for the simultaneous analysis of free fatty acids. J Biochem, 2021, 170, 389-397. (Correspondence)
https://doi.org/10.1093/jb/mvab054

21. Han B, Lee‐Okada HC, Ishimine M, Orita H, Nishikawa K, Takagaki T, Kajino K, Yokomizo T, Hino O, Kobayashi T. Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells. FEBS Open Bio, 2020, 10, 2375-2387. (Correspondence, Co-first)
https://doi.org/10.1002/2211-5463.12985

20. Ishimine M, Yokomizo T, Lee-Okada HC. Carboxylesterase 2: A Key Enzyme in Drug and Prodrug Metabolism. Juntendo Med J, 2020, 66, 120-124. (Review, Correspondence)
http://doi.org/10.14789/jmj.2020.66.JMJ19-R18

19. Ishizuka K, Kon K, Lee-Okada HC, Arai K, Uchiyama A, Yamashina S, Yokomizo T, Ikejima K. Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice, J Gastroenterol Hepatol, 2020, 35, 1437-1448.
doi: 10.1111/jgh.15006.
PMID: 32030821

18. Kaji S, Irino T, Kusuhara M, Makuuchi R, Yamakawa Y, Tokunaga M, Tanizawa Y, Bando E, Kawamura T, Kami K, Ohashi Y, Zhang S, Orita H, Lee-Okada HC, Fukunaga T, Terashima M. Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence. Gastric Cancer. 2020, 23, 874-883.
doi: 10.1007/s10120-020-01065-5.
PMID: 32219586

17. Takahashi SS, Sou YS, Saito T, Kuma A, Yabe T, Sugiura Y, Lee HC, Suematsu M, Yokomizo T, Koike M, Terai S, Mizushima N, Waguri S, Komatsu M. Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. Life Sci Alliance, 2019, 3, e201900513.
doi: 10.26508/lsa.201900513.
PMID: 31879337

16. Fujihira H, Masahara-Negishi Y, Akimoto Y, Hirayama H, Lee HC, Story BA, Mueller WF, Jakob P, Clauder-Münster S, Steinmetz LM, Radhakrishnan SK, Kawakami H, Kamada Y, Miyoshi E, Yokomizo T, Suzuki T. Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress. Biochim Biophys Acta Mol Basis Dis, 2020, 1866, 165588.
doi: 10.1016/j.bbadis.2019.165588.
PMID: 31733337

15. Zhang S, Kohira Y, Orita H, Ishimine M, Kobayashi T, Buendia Chua SM, Nakaoka H, Inoue I, Hino O, Yokomizo T, Fukunaga T, Lee-Okada HC. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation. BPB Reports, 2019, 2, 130-133. (Correspondence)
doi: 10.1248/bpbreports.2.6_130
https://www3.e-kenkyu.com/bpb-reports-online-journal/papers/29?number=6&volume=2&year=2019

14. Lee HC, Tominaga M, Yasukawa K, Ohba M, Takahashi N, Honda K, Okuno T, Takamori K, Yokomizo T. Dietary supplementation of omega-3 fatty acid eicosapentaenoic acid does not ameliorate pruritus in murine models of atopic dermatitis and psoriasis. J Dermatol Sci, 2019, 95, 130-133. (Correspondence)
doi: 10.1016/j.jdermsci.2019.07.010.
PMID: 31383390

13. Shin M, Ware TB, Lee HC, Hsu KL. Lipid-metabolizing serine hydrolases in the mammalian central nervous system: endocannabinoids and beyond. Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864, 907-921. (Review, Correspondence)
doi: 10.1016/j.bbalip.2018.08.007
PMID: 30905349

12. Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, Okuda S, Lee HC, Ikeda K, Kanegae Y, Saito I, Auwerx J, Motohashi H, Suematsu M, Soga T, Yokomizo T, Waguri S, Mizushima N, Komatsu M. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat Commun, 2019, 10, 1567.
doi: 10.1038/s41467-019-08829-3.
PMID: 30952864

11. Hirakata T, Lee HC, Ohba M, Saeki K, Okuno T, Murakami A, Matsuda A, Yokomizo T. Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses. FASEB J, 2019, 33, 3392-3403.
doi: 10.1096/fj.201801805R.
PMID: 30383446

10. Lee HC, Yokomizo T. Applications of mass spectrometry-based targeted and non-targeted lipidomics. Biochem Biophys Res Commun, 2018, 504, 576-581. (Review, Correspondence).
doi: 10.1016/j.bbrc.2018.03.081.
PMID: 29534960

9. Kawanishi N, Takagi K, Lee HC, Nakano D, Okuno T, Yokomizo T, Machida S. Endurance exercise training and high-fat diet differentially affect composition of diacylglycerol molecular species in rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol, 2018, 314, R892-R901. (Co-first)
doi: 10.1152/ajpregu.00371.2017.
PMID: 29443549

8. Ishimine M, Lee HC, Nakaoka H, Orita H, Kobayashi T, Mizuguchi K, Endo M, Inoue I, Sato K, Yokomizo T. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer. Dis Markers, 2018, 2018, 5280736. (Correspondence, Co-first)
doi: 10.1155/2018/5280736.
PMID: 29651325

7. Cognetta AB 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chem Biol, 2015, 22, 928-37.
doi: 10.1016/j.chembiol.2015.05.018.
PMID: 26120000

6. Lee HC, Simon GM, Cravatt BF. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Biochemistry, 2015, 54, 2539-49. (Correspondence)
doi: 10.1021/acs.biochem.5b00207.
PMID: 25853435

5. Hirata Y, Yamamori N, Kono N, Lee HC, Inoue T, Arai H. Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein. Genes Cells, 2013, 18, 397-409.
doi: 10.1111/gtc.12046.
PMID: 23510452

4. Lee HC, Inoue T, Sasaki J, Kubo T, Matsuda S, Nakasaki Y, Hattori M, Tanaka F, Udagawa O, Kono N, Itoh T, Ogiso H, Taguchi R, Arita M, Sasaki T, Arai H. LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol Biol Cell, 2012, 23, 4689-4700.
doi: 10.1091/mbc.E12-09-0673.
PMID: 23097495

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李 賢哲（リ ケンテツ）

李賢哲（リケンテツ）