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吉原利典（ヨシハラトシノリ）

研究テーマ	骨格筋萎縮制御機構の解明と対抗策の開発
研究業績（論文）	Uda M,Yoshihara T,Ichinoseki-Sekine N, Baba T. Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats. Physiol Rep. 2024. 査読有 Yoshihara T, Dobashi S, Naito H. Pre-heating stress associated with acute oral leucine supplementation effects in rat gastrocnemius muscle: implications for protein synthesis signaling pathways. Thermal Biol. 119, 103801, 2024. 査読有 Yoshihara T, Dobashi S, Naito H. Effects of preconditioning with heat stress on acute exercise-induced intracellular signaling in male rat gastrocnemius muscle. Physiol Rep. 12, e15913, 2024. 査読有 Dobashi S, Naito H, Yoshihara T. Cage restriction-induced physical inactivity promotes subsequent hepatic apoptosis during tail suspension in young male rats. Physiol. Rep. 11, e15695, 2023. 査読有 Kobayashi T, Ogura Y, Kishiro S, Kurosaka M, Yoshihara T, Kakigi R, Manakawa N, Uehara K, Suzuki T, Goto K, Niki H. Impacts of myosin heavy chain phenotypes on recovery of leg extension force after ACL-reconstructed knee. The Journal of Physical Fitness and Sports Medicine, 12(3), 77-85, 2023. 査読有吉原利典. 骨格筋におけるエピジェネティック修飾の加齢変化.「運動適応におけるエピジェネティクス」, 体育の科学72, 杏林書院, 東京, 818-823, 2022年12月. 1) Tsuzuki T, Yoshihara T, Ichinoseki-Sekine N, Kobayashi H, Negishi T, Yukawa K, Naito H. Exercise training improves obesity-induced inflammatory signaling in rat brown adipose tissue. Biochemistry and Biophysics Reports, 32, 101398, 2022. 査読有 2) Yoshihara T, Dobashi S, Takaragawa M, Naito H. Effect of losartan treatment on Smad signaling and recovery from hindlimb unloading-induced soleus muscle atrophy in female rats. Eur J Pharmacol. 931, 175223, 2022. 査読有 3) Ishihara Y, Ozaki H, Nakagata T, Yoshihara T, Natsume T, Kitada T, Ishibashi M, Deng P, Yamada Y, Kobayashi H, Machida S, Naito H. Association between Daily Physical Activity and Locomotive Syndrome in Community-Dwelling Japanese Older Adults: A Cross-Sectional Study. Int J Environ Res Public Health. 19(13); 8164, 2022. 査読有 4) Yoshihara T, Takaragawa M, Dobashi S, Naito H. Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-β signaling. J Physiol Sci. 72; 6, 2022. 査読有 5) Chang S-w, Yoshihara T(Contributed equally), Tsuzuki T, Natsume T, Kakigi R, Machida S, Naito H. Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. PLoS ONE. 17(2); e0264171, 2022. 査読有 6) 吉原利典, 内藤久士. 骨格筋肥大のサイエンスとトレーニングへの応用 Chapter 5 先進的レジスタンストレーニングの実践, pp 123-136, 2021. 7) Natsume T, Ozaki H, Nakagata T, Yoshihara T, Kitada T, Ishihara Y, Deng P, Osawa T, Sawada S, Kobayashi H, Machida S, Naito H. Site-Specific Muscle Loss in the Abdomen and Anterior Thigh in Elderly Males with Locomotive Syndrome.J Sports Sci Med. 20(4); 635-641, 2021. 査読有 8) Sawada S, Ozaki H, Natsume T, Deng P, Yoshihara T, Nakagata T, Osawa T, Ishihara Y, Kitada T, Kimura K, Sato N, Machida S, Naito H.The 30-s chair stand test can be a useful tool for screening sarcopenia in elderly Japanese participants. BMC Musculoskel Disord. 22(1); 639, 2021. 査読有 9) Nguyen BL, Yoshihara T, Deminice R, Lawrence J, Ozdemir M, Hyatt H, Powers SK. Alterations in renin-angiotensin receptors are not responsible for exercise preconditioning of skeletal muscle fibers. Sports Medicine and Health Science. 3(3); 148-156,2021. 査読有 10) Sawada S, Ozaki H, Natsume T, Nakano D, Deng P, Yoshihara T, Naito, H. Serum Albumin Levels as a Predictive Biomarker for Low-Load Resistance Training Programs’ Effects on Muscle Thickness in the Community-Dwelling Elderly Japanese Population: Results From the Interventional Study. BMC geriatrics. 21(1); 464-464, 2021. 査読有 11) Yoshihara T, Deminice R, Hyatt H, Ozdemir M, Nguyen B, Powers SK. Angiotensin 1-7 protects against ventilator-induced diaphragm dysfunction. Clin Transl Sci. 14(4);1512-1523, 2021. 査読有 12) Yoshihara T, Natsume T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Machida S, Naito H. Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle.J Appl Physiol. 130(4); 1214-1225J , 2021. 査読有 13) Hyatt H, Ozdemir M, Yoshihara T, Nguyen B, Deminice R, Powers SK. Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction.Redox Biol.38; 101802, 2021. 査読有 14) Uda M,Yoshihara T,Ichinoseki-Sekine N, Baba T, Yoshioka T. Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats. PLoS One.15(12): e0243660, 2020. 査読有 15) Yoshihara T, Naito H. Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: a narrative literature review. J Physiol Sci.70(1); 55, 2020. 査読有 16) Ogura Y, Kakehashi C, Yoshihara T, Kurosaka M, Kakigi R, Higashida K, Fujiwara SE, Akema T, Funabashi T.Ketogenic diet feeding improves aerobic metabolism property in extensor digitorum longus muscle of sedentary male rats. PLoS One.15(10), e0241382, 2020.査読有 17) Ozaki H, Sawada S, Osawa T, Natsume T, Yoshihara T, Deng P, Machida S, Naito H. Muscle Size and Strength of the Lower Body in Supervised and in Combined Supervised and Unsupervised Low-Load Resistance Training. Journal of Sports Science and Medicine. 19, 721-726, 2020. 査読有 18) 吉原利典. パワーズ運動生理学 Section 1 第2章内部環境の制御, メディカルサイエンスインターナショナル, pp 32-42, 2020. 19) 深尾宏祐, 高澤祐治, 吉原利典（分担執筆）. パワーズ運動生理学 Section 2 第17章特別な配慮を要する集団に対する運動処方, メディカルサイエンスインターナショナル, pp 403-430, 2020. 20) Deminice R, Hyatt H, Yoshihara T, Ozdemir M, Nguyen B, Levine S, Powers SK. Human and Rodent Skeletal Muscles Express Angiotensin II Type 1 Receptors. Cells. 9(7), 1688, 2020.査読有 21) Yoshihara T, Machida S, Naito H. Can Blood Parameters Predict the Risk of Locomotive Syndrome in Middle-Aged and Older Individuals? A Literature Review.Int J Phys Med Rehabil. 8(2), 1000546, 2020. (Editor Invited) 査読有 22) Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci. 9(5), 415-425, 2020. (Editor Invited) 査読有 23) Ozaki H, Nakagata T, Yoshihara T, Kitada T, Natsume T, Ishihara Y, Deng P, Kobayashi H, Machida S, Naito H. Effects of Progressive Walking and Stair-Climbing Training .rogram on Muscle Size and Strength of the Lower Body in Untrained Older Adults. J Sports Sci Med.18(4), 722, 2019. 査読有 24) Yoshihara T. Epigenetic mechanisms for prevention of skeletal muscle atrophy. Impact.(7), 81-83, 2019.(Editor Invited) 25) Yoshihara T, Chang SW, Tsuzuki T, Natsume T, Kakigi R, Sugiura T, Naito H. Sex-specific differences in rat soleus-muscle signaling pathway responses to a bout of horizontal and downhill running. J Physiol Biochem. 75(4), 585-595, 2019. 査読有 26) Yoshihara T, Machida S, Tsuzuki T, Kakigi R, Chang SW, Sugiura T, Naito H. Age-related changes in histone modification in rat gastrocnemius muscle. Exp Gerontol. 125, 110658, 2019. 査読有 27) Yoshihara T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H. Exercise preconditioning attenuates hind limb unloading-induced gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in old rats. Exp Gerontol. 122, 34-41, 2019. 査読有 28) Yoshihara T, Sugiura T, Shibaguchi T, Naito H. Role of Astaxanthin Supplementation in Prevention of Disuse Muscle Atrophy: A Review. The Journal of Physical Fitness and Sports Medicine. 8(2): 61-71, 2019. 査読有 29) Yoshihara T. Age-specific signaling responses to skeletal muscle disuse: A literature review. Biomed J Sci Tech Res. 16(3), 11776-11778, 2019. (Editor Invited) 査読無 30) Yoshihara T, Ozaki H, Nakagata T, Natsume T, Kitada T, Ishihara Y, Sawada S, Ishibashi M, Kobayashi H, Machida S, Naito H. Association between Locomotive Syndrome and blood parameters in Japanese middle-aged and elderly individuals: A cross-sectional study. BMC Musculoskelet Disord. 20: 104, 2019. 査読有 31) Yoshihara T, Naito H. Sex-related adaptation to disuse-induced skeletal muscle wasting. Biomed J Sci Tech Res. 14(1), 10644-10646, 2019. (Editor Invited) 査読無 32) Yoshihara T, Natsume T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H. Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle. J Physiol Sci. 69(2), 235-244, 2019. 査読有 33) Shibaguchi T, Hoshi M, Yoshihara T, Naito H, Goto K, Yoshioka T, Sugiura T. Impact of different temperature stimuli on the expression of myosin heavy chain isoforms during recovery from bupivacaine-induced muscle injury in rats. J Appl Physiol (1985), 127(1), 178-189, 2019. 査読有 34) Natsume T, Yoshihara T, Naito H. Electromyostimulation with blood flow restriction enhances activation of mTOR and MAPK signaling pathways in rat gastrocnemius muscles. Applied Physiology, Nutrition, and Metabolism. 44(6), 637-644, 2019. 査読有 35) Morton AB, Smuder AJ, Wiggs MP, Hall SE, Ahn B, Hinkley JM, Ichinoseki-Sekine N, Huertas AM, Ozdemir M, Yoshihara T, Wawrzyniak NR, Powers SK. Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction. Redox Biol. 20: 402-413, 2019. 査読有 36) Hyatt H, Deminice R, Yoshihara T, Powers SK. Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects. Arch Biochem Biophys. 662: 49-60, 2018. 査読有 37) Tsuzuki T, Yoshihara T, Ichinoseki-Sekine N, Kakigi R, Takamine Y, Kobayashi H, Naito H. Body temperature elevation during exercise is essential for activating the Akt signaling pathway in the skeletal muscle of type 2 diabetic rats. PLoS One. 13(10): e0205456, 2018. 査読有 38) Yoshihara T, Ozaki H, Nakagata T, Natsume T, Kitada T, Ishihara Y, Deng P, Osawa T, Ishibashi M, Ishijima M, Kobayashi H, Machida S, Naito H. Effects of a progressive walking program on the risk of developing locomotive syndrome in elderly Japanese people: a single-arm trial. J. Phys. Ther. Sci. 30(9): 1180-1186, 2018. 査読有 39) Yoshihara T, Sugiura T, Miyaji N, Yamamoto Y, Shibaguchi T, Kakigi R, Naito H, Goto K, Ohmori D, Yoshioka T. Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy. Journal of Zhejiang University-SCIENCE B. 19(11): 844-852, 2018. 査読有 40) Shibaguchi T, Maeoka T, Yoshihara T, Naito H, Goto K, Yoshioka T, Sugiura T. Age-related changes in myostatin expression in rat skeletal muscles. The Journal of Physical Fitness and Sports Medicine. 7; 4: 221-227, 2018. 査読有 41) Yamashita Y, Nakada S, Yoshihara T, Nara T, Furuya N, Miida T, Hattori N, Arikawa-Hirasawa. Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep. 17; 8(1): 7766, 2018. 査読有 42) Takamine Y, Ichinoseki-Sekine N, Tsuzuki T, Yoshihara T, Naito H. Effects of voluntary running exercise on bone histology in type 2 diabetic rats. PLoS One. 15; 13(2): e0193068, 2018. 査読有 43) Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. PLoS Genet. 13(8): e1006950, 2017. 査読有 44) Chang S W, Yoshihara T, Naito H. Assessing lower limb muscle strength in the elderly: Locomotive syndrome risk test in Japan. Quarterly of Chinese Physical Education. 31(4): 337-348, 2017. (In Chinese) 査読有 45) Yoshihara T, Kakigi R, Naito H. Heat stress induces FoxO3a phosphorylation in rat skeletal muscle. Musculoskeletal Regeneration. 3, e1514, 2017. (Editor Invited) 査読無 46) Tsuzuki T, Kobayashi H, Yoshihara T, Kakigi R, Ichinoseki-Sekine N, Naito H. Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes. Cell Stress Chaperones. 22(2):　263-269, 2017. 査読有 47) Chang S-w, Yoshihara T, Machida S, Naito H. Circadian rhythm of intracellular protein synthesis signaling in rat cardiac and skeletal muscles. Biochem Biophys Rep. 9, 153-8, 2017. 査読有 48) Yoshihara T, Yamamoto Y, Shibaguchi T, Miyaji N, Kakigi R, Naito H, Goto K, Ohmori D, Yoshioka T, Sugiura T. Dietary astaxanthin supplementation attenuates disuse-induced muscle atrophy and myonuclear apoptosis in the rat soleus muscle. J Physiol Sci. 67(1), 181-190, 2017. 査読有 49) Yoshihara T, Kobayashi H, Kakigi R, Sugiura T, Naito H. Heat stress-induced phosphorylation of FoxO3a signaling in rat skeletal muscle. Acta Physiol (Oxf). 218(3), 178-187, 2016. 査読有 50) Yoshihara T, Sugiura T, Naito H. Astaxanthin supplementation attenuates disuse muscle atrophy and myonuclear apoptosis in rat skeletal muscle. Musculoskeletal Regeneration. 2, e1431, 2016.(Editor Invited) 査読無 51) Yoshihara T, Machida S, Naito H. Disuse-induced nuclear accumulation of histone deacetylase 4 in rat skeletal muscle. Musculoskeletal Regeneration. 2, e1368, 2016.(Editor Invited) 査読無 52) Yoshihara T, Sugiura T, Naito H. Heat stress-induced protection against skeletal muscle atrophy via suppression of the apoptotic and proteolytic systems. Musculoskeletal Regeneration. 2, e1255, 2016.(Editor Invited) 査読無 53) Shibaguchi T, Yamaguchi Y, Miyaji N, Yoshihara T, Naito H, Goto K, Ohmori D, Yoshioka T, Sugiura T. Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats. Physiol Rep. 4(15), e12885, 2016. 査読有 54) Yoshihara T, Machida S, Kurosaka Y, Kakigi R, Sugiura T, Naito H. Immobilization induces nuclear accumulation of HDAC4 in rat skeletal muscle. J Physiol Sci. 66(4):337-43. 2016. 査読有 55) Yoshihara T, Ozaki H, Nakagata T, Natsume T, Machida S, Naito H. Effect of 6-month walking and stair-climbing exercise program and walking with blood flow restriction on body composition and hemoglobin A1c levels in elderly people. Juntendo Medical Journal. 62 (Suppl 1), 231-5, 2016. 査読無 56) Shibaguchi T, Sugiura T, Fujitsu T, Nomura T, Yoshihara T, Naito H, Yoshioka T, Ogura A, Ohira Y. Effects of icing or heat stress on the induction of fibrosis and/or regeneration of injured rat soleus muscle. J Physiol Sci. 66(4):345-57. 2016. 査読有 57) Yoshihara T, Sugiura T, Yamamoto Y, Shibaguchi T, Kakigi R, Naito H. The response of apoptotic and proteolytic systems to repeated heat stress in atrophied rat skeletal muscle. Physiol Rep. 3(10), e12597, 2015. 査読有 58) Yoshihara T, Ichinoseki-Sekine N, Kakigi R, Tsuzuki T, Sugiura T, Powers SK, Naito H. Repeated exposure to heat stress results in a diaphragm phenotype that resists ventilator-induced diaphragm dysfunction. J Appl Physiol, 119(9), 1023-31, 2015. 査読有 59) Ichinoseki-Sekine N, Yoshihara T, Kakigi R, Sugiura T, Powers SK, Naito H, Heat stress protects against mechanical ventilation-induced diaphragmatic atrophy, J Appl Physiol, 117(5); 518-24, 2014. 査読有 60) 内藤久士, 町田修一, 吉原利典（分担執筆）. ニュー運動生理学（I）Session5 運動と筋－4骨格筋の肥大と萎縮, 真興交易㈱医書出版部, pp 224-233, 2014. 61) Kakigi R, Yoshihara T, Ozaki H, Ogura Y, Ichinoseki-Sekine N, Kobayashi H, Naito H. Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle, Eur J Appl Physiol. 114(4), 735-42, 2014. 査読有 62) Yoshihara T, Naito H, Kakigi R, Ichinoseki-Sekine N, Ogura Y, Sugiura T, Katamoto S. Heat stress activates the Akt/mTOR signaling pathway in rat skeletal muscle, Acta Physiol. 207(2), 416-26, 2013. 査読有 63) Ichinoseki-Sekine N, Yoshihara T, Kakigi R, Ogura Y, Sugiura T, Naito H. Fiber-type specific expression of α-actinin isoforms in rat skeletal muscle, Biochem Biophys Res Commun, 419(2), 401-4, 2012. 査読有 64) Naito H, Yoshihara T, Kakigi R, Ichinoseki-Sekine N, Tsuzuki T. Heat stress-induced changes in skeletal muscle: heat shock proteins and cell signaling transduction. The Journal of Physical Fitness and Sports Medicine, 1 (1), 125-31, 2012. 査読無 65) Ogura Y, Naito H, Kakigi R, Ichinoseki-Sekine N, Kurosaka M, Yoshihara T, Akema T. Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle, Acta Physiol, 202(4), 683-90, 2011. 査読有 66) Kakigi R, Naito H, Ogura Y, Kobayashi H, Saga N, Ichinoseki-Sekine N, Yoshihara T, Katamoto S. Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle. J Physiol Sci, 61, 131-140, 2011. 査読有 67) 吉原利典, 杉浦崇夫, 芝口翼, 山元勇樹, 後藤勝正, 磯山智美, 内藤久士, 大森大二郎,吉岡利忠. 熱ストレス負荷とアスタキサンチン投与の組み合わせが廃用性筋萎縮に与える影響. 体力科学, 日本体力医学会, 59(3), 303-312, 2010. 査読有 68) 芝口翼, 杉浦崇夫, 古川達也, 吉原利典, 山元勇樹, 後藤勝正, 内藤久士, 大森大二郎,吉岡利忠. 間欠的な再負荷と温熱負荷の組み合わせによる骨格筋萎縮の抑制. 山口県体育学研究, 山口県体育学会, 53, 1-8, 2010. 査読有 69) 杉浦崇夫, 芝口翼, 吉原利典, 山元勇樹, 後藤勝正, 内藤久士, 吉岡利忠. 萎縮ラットヒラメ筋のデスミン発現に及ぼす熱ストレス効果. 体力科学, 日本体力医学会, 59(1), 167-174, 2010. 査読有

研究テーマ

骨格筋萎縮制御機構の解明と対抗策の開発

研究業績（論文）

Uda M,Yoshihara T,Ichinoseki-Sekine N, Baba T. Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats. Physiol Rep. 2024. 査読有

Yoshihara T, Dobashi S, Naito H. Pre-heating stress associated with acute oral leucine supplementation effects in rat gastrocnemius muscle: implications for protein synthesis signaling pathways. Thermal Biol. 119, 103801, 2024. 査読有

Yoshihara T, Dobashi S, Naito H. Effects of preconditioning with heat stress on acute exercise-induced intracellular signaling in male rat gastrocnemius muscle. Physiol Rep. 12, e15913, 2024. 査読有

Dobashi S, Naito H, Yoshihara T. Cage restriction-induced physical inactivity promotes subsequent hepatic apoptosis during tail suspension in young male rats. Physiol. Rep. 11, e15695, 2023. 査読有

Kobayashi T, Ogura Y, Kishiro S, Kurosaka M, Yoshihara T, Kakigi R, Manakawa N, Uehara K, Suzuki T, Goto K, Niki H. Impacts of myosin heavy chain phenotypes on recovery of leg extension force after ACL-reconstructed knee. The Journal of Physical Fitness and Sports Medicine, 12(3), 77-85, 2023. 査読有

吉原利典. 骨格筋におけるエピジェネティック修飾の加齢変化.「運動適応におけるエピジェネティクス」, 体育の科学72, 杏林書院, 東京, 818-823, 2022年12月.

1) Tsuzuki T, Yoshihara T, Ichinoseki-Sekine N, Kobayashi H, Negishi T, Yukawa K, Naito H. Exercise training improves obesity-induced inflammatory signaling in rat brown adipose tissue. Biochemistry and Biophysics Reports, 32, 101398, 2022. 査読有

2) Yoshihara T, Dobashi S, Takaragawa M, Naito H. Effect of losartan treatment on Smad signaling and recovery from hindlimb unloading-induced soleus muscle atrophy in female rats. Eur J Pharmacol. 931, 175223, 2022. 査読有

3) Ishihara Y, Ozaki H, Nakagata T, Yoshihara T, Natsume T, Kitada T, Ishibashi M, Deng P, Yamada Y, Kobayashi H, Machida S, Naito H. Association between Daily Physical Activity and Locomotive Syndrome in Community-Dwelling Japanese Older Adults: A Cross-Sectional Study. Int J Environ Res Public Health. 19(13); 8164, 2022. 査読有

4) Yoshihara T, Takaragawa M, Dobashi S, Naito H. Losartan treatment attenuates hindlimb unloading-induced atrophy in the soleus muscle of female rats via canonical TGF-β signaling. J Physiol Sci. 72; 6, 2022. 査読有

5) Chang S-w, Yoshihara T(Contributed equally), Tsuzuki T, Natsume T, Kakigi R, Machida S, Naito H. Circadian rhythms modulate the effect of eccentric exercise on rat soleus muscles. PLoS ONE. 17(2); e0264171, 2022. 査読有

6) 吉原利典, 内藤久士. 骨格筋肥大のサイエンスとトレーニングへの応用 Chapter 5 先進的レジスタンストレーニングの実践, pp 123-136, 2021.

7) Natsume T, Ozaki H, Nakagata T, Yoshihara T, Kitada T, Ishihara Y, Deng P, Osawa T, Sawada S, Kobayashi H, Machida S, Naito H. Site-Specific Muscle Loss in the Abdomen and Anterior Thigh in Elderly Males with Locomotive Syndrome.J Sports Sci Med. 20(4); 635-641, 2021. 査読有

8) Sawada S, Ozaki H, Natsume T, Deng P, Yoshihara T, Nakagata T, Osawa T, Ishihara Y, Kitada T, Kimura K, Sato N, Machida S, Naito H.The 30-s chair stand test can be a useful tool for screening sarcopenia in elderly Japanese participants. BMC Musculoskel Disord. 22(1); 639, 2021. 査読有

9) Nguyen BL, Yoshihara T, Deminice R, Lawrence J, Ozdemir M, Hyatt H, Powers SK. Alterations in renin-angiotensin receptors are not responsible for exercise preconditioning of skeletal muscle fibers. Sports Medicine and Health Science. 3(3); 148-156,2021. 査読有

10) Sawada S, Ozaki H, Natsume T, Nakano D, Deng P, Yoshihara T, Naito, H. Serum Albumin Levels as a Predictive Biomarker for Low-Load Resistance Training Programs’ Effects on Muscle Thickness in the Community-Dwelling Elderly Japanese Population: Results From the Interventional Study. BMC geriatrics. 21(1); 464-464, 2021. 査読有

11) Yoshihara T, Deminice R, Hyatt H, Ozdemir M, Nguyen B, Powers SK. Angiotensin 1-7 protects against ventilator-induced diaphragm dysfunction. Clin Transl Sci. 14(4);1512-1523, 2021. 査読有

12) Yoshihara T, Natsume T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Machida S, Naito H. Long-term physical inactivity exacerbates hindlimb unloading-induced muscle atrophy in young rat soleus muscle.J Appl Physiol. 130(4); 1214-1225J , 2021. 査読有

13) Hyatt H, Ozdemir M, Yoshihara T, Nguyen B, Deminice R, Powers SK. Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction.Redox Biol.38; 101802, 2021. 査読有

14) Uda M,Yoshihara T,Ichinoseki-Sekine N, Baba T, Yoshioka T. Potential roles of neuronal nitric oxide synthase and the PTEN-induced kinase 1 (PINK1)/Parkin pathway for mitochondrial protein degradation in disuse-induced soleus muscle atrophy in adult rats. PLoS One.15(12): e0243660, 2020. 査読有

15) Yoshihara T, Naito H. Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: a narrative literature review. J Physiol Sci.70(1); 55, 2020. 査読有

16) Ogura Y, Kakehashi C, Yoshihara T, Kurosaka M, Kakigi R, Higashida K, Fujiwara SE, Akema T, Funabashi T.Ketogenic diet feeding improves aerobic metabolism property in extensor digitorum longus muscle of sedentary male rats. PLoS One.15(10), e0241382, 2020.査読有

17) Ozaki H, Sawada S, Osawa T, Natsume T, Yoshihara T, Deng P, Machida S, Naito H. Muscle Size and Strength of the Lower Body in Supervised and in Combined Supervised and Unsupervised Low-Load Resistance Training. Journal of Sports Science and Medicine. 19, 721-726, 2020. 査読有

18) 吉原利典. パワーズ運動生理学 Section 1 第2章内部環境の制御, メディカルサイエンスインターナショナル, pp 32-42, 2020.

19) 深尾宏祐, 高澤祐治, 吉原利典（分担執筆）. パワーズ運動生理学 Section 2 第17章特別な配慮を要する集団に対する運動処方, メディカルサイエンスインターナショナル, pp 403-430, 2020.

20) Deminice R, Hyatt H, Yoshihara T, Ozdemir M, Nguyen B, Levine S, Powers SK. Human and Rodent Skeletal Muscles Express Angiotensin II Type 1 Receptors. Cells. 9(7), 1688, 2020.査読有

21) Yoshihara T, Machida S, Naito H. Can Blood Parameters Predict the Risk of Locomotive Syndrome in Middle-Aged and Older Individuals? A Literature Review.Int J Phys Med Rehabil. 8(2), 1000546, 2020. (Editor Invited) 査読有

22) Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci. 9(5), 415-425, 2020. (Editor Invited) 査読有

23) Ozaki H, Nakagata T, Yoshihara T, Kitada T, Natsume T, Ishihara Y, Deng P, Kobayashi H, Machida S, Naito H. Effects of Progressive Walking and Stair-Climbing Training .rogram on Muscle Size and Strength of the Lower Body in Untrained Older Adults. J Sports Sci Med.18(4), 722, 2019. 査読有

24) Yoshihara T. Epigenetic mechanisms for prevention of skeletal muscle atrophy. Impact.(7), 81-83, 2019.(Editor Invited)

25) Yoshihara T, Chang SW, Tsuzuki T, Natsume T, Kakigi R, Sugiura T, Naito H. Sex-specific differences in rat soleus-muscle signaling pathway responses to a bout of horizontal and downhill running. J Physiol Biochem. 75(4), 585-595, 2019. 査読有

26) Yoshihara T, Machida S, Tsuzuki T, Kakigi R, Chang SW, Sugiura T, Naito H. Age-related changes in histone modification in rat gastrocnemius muscle. Exp Gerontol. 125, 110658, 2019. 査読有

27) Yoshihara T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H. Exercise preconditioning attenuates hind limb unloading-induced gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in old rats. Exp Gerontol. 122, 34-41, 2019. 査読有

28) Yoshihara T, Sugiura T, Shibaguchi T, Naito H. Role of Astaxanthin Supplementation in Prevention of Disuse Muscle Atrophy: A Review. The Journal of Physical Fitness and Sports Medicine. 8(2): 61-71, 2019. 査読有

29) Yoshihara T. Age-specific signaling responses to skeletal muscle disuse: A literature review. Biomed J Sci Tech Res. 16(3), 11776-11778, 2019. (Editor Invited) 査読無

30) Yoshihara T, Ozaki H, Nakagata T, Natsume T, Kitada T, Ishihara Y, Sawada S, Ishibashi M, Kobayashi H, Machida S, Naito H. Association between Locomotive Syndrome and blood parameters in Japanese middle-aged and elderly individuals: A cross-sectional study. BMC Musculoskelet Disord. 20: 104, 2019. 査読有

31) Yoshihara T, Naito H. Sex-related adaptation to disuse-induced skeletal muscle wasting. Biomed J Sci Tech Res. 14(1), 10644-10646, 2019. (Editor Invited) 査読無

32) Yoshihara T, Natsume T, Tsuzuki T, Chang SW, Kakigi R, Sugiura T, Naito H. Sex differences in forkhead box O3a signaling response to hindlimb unloading in rat soleus muscle. J Physiol Sci. 69(2), 235-244, 2019. 査読有

33) Shibaguchi T, Hoshi M, Yoshihara T, Naito H, Goto K, Yoshioka T, Sugiura T. Impact of different temperature stimuli on the expression of myosin heavy chain isoforms during recovery from bupivacaine-induced muscle injury in rats. J Appl Physiol (1985), 127(1), 178-189, 2019. 査読有

34) Natsume T, Yoshihara T, Naito H. Electromyostimulation with blood flow restriction enhances activation of mTOR and MAPK signaling pathways in rat gastrocnemius muscles. Applied Physiology, Nutrition, and Metabolism. 44(6), 637-644, 2019. 査読有

35) Morton AB, Smuder AJ, Wiggs MP, Hall SE, Ahn B, Hinkley JM, Ichinoseki-Sekine N, Huertas AM, Ozdemir M, Yoshihara T, Wawrzyniak NR, Powers SK. Increased SOD2 in the diaphragm contributes to exercise-induced protection against ventilator-induced diaphragm dysfunction. Redox Biol. 20: 402-413, 2019. 査読有

36) Hyatt H, Deminice R, Yoshihara T, Powers SK. Mitochondrial dysfunction induces muscle atrophy during prolonged inactivity: A review of the causes and effects. Arch Biochem Biophys. 662: 49-60, 2018. 査読有

37) Tsuzuki T, Yoshihara T, Ichinoseki-Sekine N, Kakigi R, Takamine Y, Kobayashi H, Naito H. Body temperature elevation during exercise is essential for activating the Akt signaling pathway in the skeletal muscle of type 2 diabetic rats. PLoS One. 13(10): e0205456, 2018. 査読有

38) Yoshihara T, Ozaki H, Nakagata T, Natsume T, Kitada T, Ishihara Y, Deng P, Osawa T, Ishibashi M, Ishijima M, Kobayashi H, Machida S, Naito H. Effects of a progressive walking program on the risk of developing locomotive syndrome in elderly Japanese people: a single-arm trial. J. Phys. Ther. Sci. 30(9): 1180-1186, 2018. 査読有

39) Yoshihara T, Sugiura T, Miyaji N, Yamamoto Y, Shibaguchi T, Kakigi R, Naito H, Goto K, Ohmori D, Yoshioka T. Effect of a combination of astaxanthin supplementation, heat stress, and intermittent reloading on satellite cells during disuse muscle atrophy. Journal of Zhejiang University-SCIENCE B. 19(11): 844-852, 2018. 査読有

40) Shibaguchi T, Maeoka T, Yoshihara T, Naito H, Goto K, Yoshioka T, Sugiura T. Age-related changes in myostatin expression in rat skeletal muscles. The Journal of Physical Fitness and Sports Medicine. 7; 4: 221-227, 2018. 査読有

41) Yamashita Y, Nakada S, Yoshihara T, Nara T, Furuya N, Miida T, Hattori N, Arikawa-Hirasawa. Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep. 17; 8(1): 7766, 2018. 査読有

42) Takamine Y, Ichinoseki-Sekine N, Tsuzuki T, Yoshihara T, Naito H. Effects of voluntary running exercise on bone histology in type 2 diabetic rats. PLoS One. 15; 13(2): e0193068, 2018. 査読有

43) Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression. PLoS Genet. 13(8): e1006950, 2017. 査読有

44) Chang S W, Yoshihara T, Naito H. Assessing lower limb muscle strength in the elderly: Locomotive syndrome risk test in Japan. Quarterly of Chinese Physical Education. 31(4): 337-348, 2017. (In Chinese) 査読有

45) Yoshihara T, Kakigi R, Naito H. Heat stress induces FoxO3a phosphorylation in rat skeletal muscle. Musculoskeletal Regeneration. 3, e1514, 2017. (Editor Invited) 査読無

46) Tsuzuki T, Kobayashi H, Yoshihara T, Kakigi R, Ichinoseki-Sekine N, Naito H. Attenuation of exercise-induced heat shock protein 72 expression blunts improvements in whole-body insulin resistance in rats with type 2 diabetes. Cell Stress Chaperones. 22(2):　263-269, 2017. 査読有

47) Chang S-w, Yoshihara T, Machida S, Naito H. Circadian rhythm of intracellular protein synthesis signaling in rat cardiac and skeletal muscles. Biochem Biophys Rep. 9, 153-8, 2017. 査読有

48) Yoshihara T, Yamamoto Y, Shibaguchi T, Miyaji N, Kakigi R, Naito H, Goto K, Ohmori D, Yoshioka T, Sugiura T. Dietary astaxanthin supplementation attenuates disuse-induced muscle atrophy and myonuclear apoptosis in the rat soleus muscle. J Physiol Sci. 67(1), 181-190, 2017. 査読有

49) Yoshihara T, Kobayashi H, Kakigi R, Sugiura T, Naito H. Heat stress-induced phosphorylation of FoxO3a signaling in rat skeletal muscle. Acta Physiol (Oxf). 218(3), 178-187, 2016. 査読有

50) Yoshihara T, Sugiura T, Naito H. Astaxanthin supplementation attenuates disuse muscle atrophy and myonuclear apoptosis in rat skeletal muscle. Musculoskeletal Regeneration. 2, e1431, 2016.(Editor Invited) 査読無

51) Yoshihara T, Machida S, Naito H. Disuse-induced nuclear accumulation of histone deacetylase 4 in rat skeletal muscle. Musculoskeletal Regeneration. 2, e1368, 2016.(Editor Invited) 査読無

52) Yoshihara T, Sugiura T, Naito H. Heat stress-induced protection against skeletal muscle atrophy via suppression of the apoptotic and proteolytic systems. Musculoskeletal Regeneration. 2, e1255, 2016.(Editor Invited) 査読無

53) Shibaguchi T, Yamaguchi Y, Miyaji N, Yoshihara T, Naito H, Goto K, Ohmori D, Yoshioka T, Sugiura T. Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats. Physiol Rep. 4(15), e12885, 2016. 査読有

54) Yoshihara T, Machida S, Kurosaka Y, Kakigi R, Sugiura T, Naito H. Immobilization induces nuclear accumulation of HDAC4 in rat skeletal muscle. J Physiol Sci. 66(4):337-43. 2016. 査読有

55) Yoshihara T, Ozaki H, Nakagata T, Natsume T, Machida S, Naito H. Effect of 6-month walking and stair-climbing exercise program and walking with blood flow restriction on body composition and hemoglobin A1c levels in elderly people. Juntendo Medical Journal. 62 (Suppl 1), 231-5, 2016. 査読無

56) Shibaguchi T, Sugiura T, Fujitsu T, Nomura T, Yoshihara T, Naito H, Yoshioka T, Ogura A, Ohira Y. Effects of icing or heat stress on the induction of fibrosis and/or regeneration of injured rat soleus muscle. J Physiol Sci. 66(4):345-57. 2016. 査読有

57) Yoshihara T, Sugiura T, Yamamoto Y, Shibaguchi T, Kakigi R, Naito H. The response of apoptotic and proteolytic systems to repeated heat stress in atrophied rat skeletal muscle. Physiol Rep. 3(10), e12597, 2015. 査読有

58) Yoshihara T, Ichinoseki-Sekine N, Kakigi R, Tsuzuki T, Sugiura T, Powers SK, Naito H. Repeated exposure to heat stress results in a diaphragm phenotype that resists ventilator-induced diaphragm dysfunction. J Appl Physiol, 119(9), 1023-31, 2015. 査読有

59) Ichinoseki-Sekine N, Yoshihara T, Kakigi R, Sugiura T, Powers SK, Naito H, Heat stress protects against mechanical ventilation-induced diaphragmatic atrophy, J Appl Physiol, 117(5); 518-24, 2014. 査読有

60) 内藤久士, 町田修一, 吉原利典（分担執筆）. ニュー運動生理学（I）Session5 運動と筋－4骨格筋の肥大と萎縮, 真興交易㈱医書出版部, pp 224-233, 2014.

61) Kakigi R, Yoshihara T, Ozaki H, Ogura Y, Ichinoseki-Sekine N, Kobayashi H, Naito H. Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle, Eur J Appl Physiol. 114(4), 735-42, 2014. 査読有

62) Yoshihara T, Naito H, Kakigi R, Ichinoseki-Sekine N, Ogura Y, Sugiura T, Katamoto S. Heat stress activates the Akt/mTOR signaling pathway in rat skeletal muscle, Acta Physiol. 207(2), 416-26, 2013. 査読有

63) Ichinoseki-Sekine N, Yoshihara T, Kakigi R, Ogura Y, Sugiura T, Naito H. Fiber-type specific expression of α-actinin isoforms in rat skeletal muscle, Biochem Biophys Res Commun, 419(2), 401-4, 2012. 査読有

64) Naito H, Yoshihara T, Kakigi R, Ichinoseki-Sekine N, Tsuzuki T. Heat stress-induced changes in skeletal muscle: heat shock proteins and cell signaling transduction. The Journal of Physical Fitness and Sports Medicine, 1 (1), 125-31, 2012. 査読無

65) Ogura Y, Naito H, Kakigi R, Ichinoseki-Sekine N, Kurosaka M, Yoshihara T, Akema T. Effects of ageing and endurance exercise training on alpha-actinin isoforms in rat plantaris muscle, Acta Physiol, 202(4), 683-90, 2011. 査読有

66) Kakigi R, Naito H, Ogura Y, Kobayashi H, Saga N, Ichinoseki-Sekine N, Yoshihara T, Katamoto S. Heat stress enhances mTOR signaling after resistance exercise in human skeletal muscle. J Physiol Sci, 61, 131-140, 2011. 査読有

67) 吉原利典, 杉浦崇夫, 芝口翼, 山元勇樹, 後藤勝正, 磯山智美, 内藤久士, 大森大二郎,吉岡利忠. 熱ストレス負荷とアスタキサンチン投与の組み合わせが廃用性筋萎縮に与える影響. 体力科学, 日本体力医学会, 59(3), 303-312, 2010. 査読有

68) 芝口翼, 杉浦崇夫, 古川達也, 吉原利典, 山元勇樹, 後藤勝正, 内藤久士, 大森大二郎,吉岡利忠. 間欠的な再負荷と温熱負荷の組み合わせによる骨格筋萎縮の抑制. 山口県体育学研究, 山口県体育学会, 53, 1-8, 2010. 査読有

69) 杉浦崇夫, 芝口翼, 吉原利典, 山元勇樹, 後藤勝正, 内藤久士, 吉岡利忠. 萎縮ラットヒラメ筋のデスミン発現に及ぼす熱ストレス効果. 体力科学, 日本体力医学会, 59(1), 167-174, 2010. 査読有

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吉原 利典（ヨシハラ トシノリ）

吉原利典（ヨシハラトシノリ）