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研究業績詳細

伝田香里（デンダカオリ）

研究テーマ	腫瘍生物学及び免疫学における糖鎖認識の重要性
研究業績（論文）	1. Sakio R, Miura T, Kihara A, Amano Y, Yoshimoto T, Ohno N, Denda-Nagai K, Irimura T, Tsubochi H, Fujita K, Hagiwara K, Maemondo M, Komura D, Ishikawa S, Ushiku T, Sata N, Kitayama J, Yamaguchi H, Fukushima N, Inamura K, Matsubara B, Niki T. Role of Upregulated Mucin 21 in Detached Lung Cancer Cells. Pathol Int 2026;76(6) e70141. 2. Horimoto Y, Hlaing MT, Saeki H, Denda-Nagai K, Ishii-Schrade K, Fujihira H, Abe M, Noji M, Shichino S, Saito M, Irimura T. Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases. Clin Exp Metastasis 2024;41(3)267-270. 3. Lee DH, Ahn H, Sim HI, Choi E, Choi S, Jo Y, Yun B, Song HK, Oh SJ, Denda-Nagai K, Park CS, Irimura T, Park Y, Jin HS. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. J Exp Clin Cancer Res 2023 42(1):272. 4. Manome-Zenke Y, Denda-Nagai K‡, Murakami R, Noji M, Tsuneda N, Ishii-Schrade KB, Kanomata N, Arai S, Irimura T, Ikeda S. Possible Involvement of Antigen-Presenting Cells Expressing the Macrophage Galactose-Type C-Type Lectin in Inflammatory Skin Diseases. J Invest Dermatol 2023;143(9):1834-1838.e10. (‡: corresponding author) 5. Semba R, Horimoto Y, Sakata-Matsuzawa M, Ishizuka Y, Denda-Nagai K, Fujihira H, Noji M, Onagi H, Ichida M, Miura H, Watanabe J, Saito M, Saito T, Arakawa A, Irimura T. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer. Sci Rep 2023;13(1):5281. 6. Murwanti R, Denda-Nagai K†, Sugiura D, Mogushi K, Gendler SJ, Irimura T†. Prevention of Inflammation-Driven Colon Carcinogenesis in Human MUC1 Transgenic Mice by Vaccination with MUC1 DNA and Dendritic Cells. Cancers (Basel) 2023;15(6):1920. (†: double corresponding authors.) 7. Hlaing MT, Horimoto Y, Denda-Nagai K, Fujihira H, Noji M, Kaji H, Tomioka A, Ishizuka Y, Saeki H, Arakawa A, Saito M, Irimura T. Tamoxifen-resistant breast cancer cells exhibit reactivity with Wisteria floribunda agglutinin. PLoS One 2022;17(8): e0273513. 8. Kokubu R, Ohno S, Kuratani H, Takahashi Y, Manabe N, Shimizu H, Chiba Y, Denda-Nagai K, Tsuiji M, Irimura T, Yamaguchi Y. O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations. Int J Mol Sci 2022;23(14):7855. 9. Nishida J, Shichino S, Tsukui T, Hoshino M, Okada T, Okada K, Yi Y, Toraya-Brown S, Mochizuki M, Koizumi R, Ishii-Schrade K, Denda-Nagai K‡, Irimura T. Unique Glycoform-Dependent Monoclonal Antibodies for Mouse Mucin 21. Int J Mol Sci. 23(12):6718, 2022. (‡: corresponding author) 10. Tian Y, Denda-Nagai K†, Tsukui T, Ishii-Schrade K, Okada K, Nishizono Y, Matsuzaki K, Hafley M, Bresalier RS, and Irimura T. Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner. Cell Death Discovery. 8, 2022. (†: double corresponding authors.) 11. Sakata-Matsuzawa M, Denda-Nagai K†, Fujihira H, NojiM, Ishii-Schrade K, Matsuda A, Kuno A, Okazaki M, Nakai K, Horimoto Y, Saito M, Irimura T†. Glycans unique to the relapse-prone subset within triple-negative breast cancer as revealed by lectin array-based analysis of surgical specimens. PLoS One 2021;16(5):e0250747. (†: double corresponding authors.) 12. Fujihira H, Takakura D, Matsuda A, Abe M, Miyazaki M, Nakagawa T, Kajino K, Denda-Nagai K, Noji M, Hino O, Irimura T. Bisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epitheloid mesothelioma cells. J Biochem 2021. published online. 13. Kurashina R, Denda-Nagai K†, Saba K, Hisai T, Hara H, Irimura T. Intestinal lamina propria macrophages upregulate Interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a. Glycobiology 2021;31(7):827-37. (: equally contributed., †: double corresponding authors.) 14. Okazaki M, Mogushi K, Denda-Nagai K†, Fujihira H, Noji M, Ishii-Schrade K, Sakata-Matsuzawa M, Nakai K, Horimoto Y, Saito M, IrimuraT†. Biological and Clinicopathological Implications of Beta-3-N-acetylglucosaminyltransferase 8 in Triple-negative Breast Cancer. Anticancer Res 2021;41(2):848-858. (†: double corresponding authors.) 15. Kanemaru K, Noguchi E, Thara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A. Clc10a regulates mite-induced dermatitis. Sci Immunol 2019;4(42) eaax6908. 16. Yoshimura Y, Denda-Nagai K†, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, Noji M, Shichino S, Chiba Y, Irimura T†. Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies. Sci Rep 2019;9(1):16641. (: equally contributed., †: double corresponding authors.) 17. Yoshimoto T, Matsubara D, Soda M, Ueno T, Amano Y, Kihara A, Sakatani T, Nakano T, Shibano T, Endo S, Hagiwara K, Fukayama M, Denda-Nagai K, Irimura T, Mano H, Niki T. Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma. Cancer Sci 2019;110(9):3006-3011. 18. Matsumura M, Okudela K, Nakashima Y, Mitsui H, Denda-Nagai K, Suzuki T, Arai H, Umeda S, Tateishi Y, Koike C, Kataoka T, Irimura T, Ohashi K. Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas - Implications for the progression of EGFR-mutated lung adenocarcinomas. PLoS One 2019;14(4):e0215237. 19. Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T. A Critical Domain of Ebolavirus Envelope Glycoprotein Determines Glycoform and Infectivity. Sci Rep 2018;8:5495. 20. Ng WC, Liong S, Tate MD, Irimura T, Denda-Nagai K, Brooks AG, Londrigan SL, Reading PC. The macrophage galactose-type lectin can function as an attachment site and entry for influenza virus. J Virol. 2014;88(3):1659-72. 21. Murakami R, Denda-Nagai K†, Hashimoto S, Nagai S, Hattori M, Irimura T†. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS One 2013;8(9):e73270. (*: equally contributed., †: double corresponding authors.) 22. Sugiura D, Denda-Nagai K†, Takashima M, Murakami R, Nagai S, Takeda K, Irimura T†. Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo. PLoS One 2012;7(9):e44770. (†: double corresponding authors.) 23. Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Tsukui T, Itoh Y, Okada K, Yi Y, Irimura T. Mucin 21in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies. Glycobiology 2012;22(9):1218-26. 24. Usami K, Matsuno K, Igarashi M, Denda-Nagai K, Takada A, Irimura T. Involvementof viral envelop GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin. Biochem Biophys Res Commun 2011;407(1):74-8. 25. Sugiura D, Denda-Nagai K, Takeda K, Irimura T. Organ microenvironment plays significant roles through Fas ligand in vccine-induced CD4(+) T cell dependent suppression of tumor growth at the orthotopic site. Cancer Sci 2010;101(9):1965-9. 26. Yi Y, Kamata-Sakurai M, Denda-Nagai K, Itoh T, Okada K, Ishii-Schrade K, Iguchi A, Sugiura D, Irimura T. Mucin 21/epiglycanin modulate cell adhesion. J Biol Chem 2010;285(28):21233-40. 27. Denda-Nagai K, Aida S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T. Distribution and function of macriphage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. J Biol Chem 2010;285(25):19193-204. 28. Kumamoto Y, Denda-Nagai K, Aida S, Higashi N, Irimura T. MGL2+ dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo. PLoS One 2009;4(5):e5619. 29. Saba K, Denda-Nagai K, Irimura T. A C-type lectin MGL1/CD301a plays an anti-inflammatory role in murine experimental colitis. Am J Pathol 2009;174(1):144-52. 30. Sugiura D, Aida S, Denda-Nagai K, Takeda K, Kamata-Sakurai M, Yagita H, Irimura T. Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases. Cancer Sci 2008;99(12):2477-84. 31. Oo-Puthinan S, Maenuma K, Sakakura M, Denda-Nagai K, Tsuiji M, Shimada I, Nakamura-Tsuruta S, Hirabayashi J, Bovin NV, Irimura T. The amino acids involved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2 (CD301a and b) of mice. Biochim Biophys Acta 2008;1780(2):89-100. 32. Itoh Y, Kamata-Sakurai M, Denda-Nagai K, Nagai S, Tsuiji M, Ishii-Schrade K, Okada K, Goto A, Fukayama M, Irimura T. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. Glycobiology 2008;18(1):74-83. 33. Napoletano C, Rughetti A, Agervig Tarp MP, Coleman J, Bennett EP, Picco G, Sale P, Denda-Nagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M. Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells. Cancer Res 2007;67(17):8358-67. 34. Sano Y, Usami K, Izawa R, Denda-Nagai K, Higashi N, Kimura T, Suzuki N, Irimura T. Properties of blocking and non-blocking monoclonal antibodies specific for human macrophge galactose-type C-type lectin (MGL/ClecSF10A/CD301). J Biochem 2007;141(1):127-36. 35. Dupasquier M, Stoitzner P, Wan H, Cerqueira D, van Oudenaren A, Voerman JS, Denda-Nagai K, Irimura T, Raes G, Romani N, Leenen PJ. The dermal microenvironment incduces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes, independent of IL-4/IL-13 signaling. J Leukoc Biol 2006;80(4):838-49. 36. Kumamoto Y, Higashi N, Denda-Nagai K, Tsuiji M, Sato K, Crocker PR, Irimura T. Identification of sialoadhesin as a dominant lymph node counter-receptor for macrophage galactose-type C-type lectin 1. J Biol Chem 2004;279(47):49274-80. 37. Kamata M, Denda-Nagai K, Kubota N, Aida S, Takeda K, Irimura T. Vaccination of mice with MUC1 cDNA suppresses the development of lung metastases. Clin Exp Metastasis 2002;19(8):689-96. 38. Takeuchi H, Kato K, Denda-Nagai K, Hanisch FG, Clausen H, Irimura T. The epitope recognized by the unique anti-MUC1 monoclonal antibody MY.1E12 involves sialy alpha 2-3galactosyl beta 1-3N-acetylgalactosaminide linked to a distinct threonine residue in the MUC1 tandem repeat. J Immunol Methods 2002;270(2):199-209. 39. Denda-Nagai K, Kubota N, Tsuiji M, Kamata M, Irimura T. Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of galactosylated antigens. Glycobiology 2002;12(7):443-50. 40. Higashi N, Fujioka K, Denda-Nagai K, Hashimoto S, Nagai S, Sato T, Fujita Y, Morikawa A, Tsuiji M, Miyata-Takeuchi M, Sano Y, Suzuki N, Yamamoto K, Matsushima K, Irimura T. The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells. J Biol Chem 2002;277(23):20686-93. 41. Denda-Nagai K, Irimura T. MUC1 in carcinoma-host interactions. Glycoconj J 2000;17(7-9):649-58. 42. Denda-Nagai K, Fujita K, Fujime M, Nakatsugawa S, Ishigaki T, Irimura T. Absence of correlations of MUC1 expression to malignant behavior of renal cell carcinoma in experimental systems. Clin Exp Metastasis 2000;18(1):77-81. 43. Irimura T, Denda K, Iida Si, Takeuchi H, Kato K. Diverse glycosylation of MUC1 and MUC2: Potential significance in tumor immunity. J Biochem 1999;126(6):975-85. 44. Fujita K, Denda K, Yamamoto M, Matsumoto T, Fujime M, Irimura T. Expression of MUC1 mucins inversely correlated with post-surgical survival of renal cell carcinoma patients. Br J Cancer 1999;80(1-2):301-8.

研究テーマ

腫瘍生物学及び免疫学における糖鎖認識の重要性

研究業績（論文）

1. Sakio R, Miura T, Kihara A, Amano Y, Yoshimoto T, Ohno N, Denda-Nagai K, Irimura T, Tsubochi H, Fujita K, Hagiwara K, Maemondo M, Komura D, Ishikawa S, Ushiku T, Sata N, Kitayama J, Yamaguchi H, Fukushima N, Inamura K, Matsubara B, Niki T. Role of Upregulated Mucin 21 in Detached Lung Cancer Cells. Pathol Int 2026;76(6) e70141.

2. Horimoto Y, Hlaing MT, Saeki H, Denda-Nagai K, Ishii-Schrade K, Fujihira H, Abe M, Noji M, Shichino S, Saito M, Irimura T. Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases. Clin Exp Metastasis 2024;41(3)267-270.

3. Lee DH, Ahn H, Sim HI, Choi E, Choi S, Jo Y, Yun B, Song HK, Oh SJ, Denda-Nagai K, Park CS, Irimura T, Park Y, Jin HS. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. J Exp Clin Cancer Res 2023 42(1):272.

4. Manome-Zenke Y, Denda-Nagai K‡, Murakami R, Noji M, Tsuneda N, Ishii-Schrade KB, Kanomata N, Arai S, Irimura T, Ikeda S. Possible Involvement of Antigen-Presenting Cells Expressing the Macrophage Galactose-Type C-Type Lectin in Inflammatory Skin Diseases. J Invest Dermatol 2023;143(9):1834-1838.e10. (‡: corresponding author)

5. Semba R, Horimoto Y, Sakata-Matsuzawa M, Ishizuka Y, Denda-Nagai K, Fujihira H, Noji M, Onagi H, Ichida M, Miura H, Watanabe J, Saito M, Saito T, Arakawa A, Irimura T. Possible correlation of apical localization of MUC1 glycoprotein with luminal A-like status of breast cancer. Sci Rep 2023;13(1):5281.

6. Murwanti R, Denda-Nagai K†, Sugiura D, Mogushi K, Gendler SJ, Irimura T†. Prevention of Inflammation-Driven Colon Carcinogenesis in Human MUC1 Transgenic Mice by Vaccination with MUC1 DNA and Dendritic Cells. Cancers (Basel) 2023;15(6):1920. (†: double corresponding authors.)

7. Hlaing MT, Horimoto Y, Denda-Nagai K, Fujihira H, Noji M, Kaji H, Tomioka A, Ishizuka Y, Saeki H, Arakawa A, Saito M, Irimura T. Tamoxifen-resistant breast cancer cells exhibit reactivity with Wisteria floribunda agglutinin. PLoS One 2022;17(8): e0273513.

8. Kokubu R, Ohno S, Kuratani H, Takahashi Y, Manabe N, Shimizu H, Chiba Y, Denda-Nagai K, Tsuiji M, Irimura T, Yamaguchi Y. O-Glycan-Dependent Interaction between MUC1 Glycopeptide and MY.1E12 Antibody by NMR, Molecular Dynamics and Docking Simulations. Int J Mol Sci 2022;23(14):7855.

9. Nishida J, Shichino S, Tsukui T, Hoshino M, Okada T, Okada K, Yi Y, Toraya-Brown S, Mochizuki M, Koizumi R, Ishii-Schrade K, Denda-Nagai K‡, Irimura T. Unique Glycoform-Dependent Monoclonal Antibodies for Mouse Mucin 21. Int J Mol Sci. 23(12):6718, 2022. (‡: corresponding author)

10. Tian Y, Denda-Nagai K†, Tsukui T, Ishii-Schrade K, Okada K, Nishizono Y, Matsuzaki K, Hafley M, Bresalier RS, and Irimura T. Mucin 21 confers resistance to apoptosis in an O-glycosylation-dependent manner. Cell Death Discovery. 8, 2022. (†: double corresponding authors.)

11. Sakata-Matsuzawa M, Denda-Nagai K†, Fujihira H, NojiM, Ishii-Schrade K, Matsuda A, Kuno A, Okazaki M, Nakai K, Horimoto Y, Saito M, Irimura T†. Glycans unique to the relapse-prone subset within triple-negative breast cancer as revealed by lectin array-based analysis of surgical specimens. PLoS One 2021;16(5):e0250747. (†: double corresponding authors.)

12. Fujihira H, Takakura D, Matsuda A, Abe M, Miyazaki M, Nakagawa T, Kajino K, Denda-Nagai K, Noji M, Hino O, Irimura T. Bisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epitheloid mesothelioma cells. J Biochem 2021. published online.

13. Kurashina R*, Denda-Nagai K*†, Saba K, Hisai T, Hara H, Irimura T. Intestinal lamina propria macrophages upregulate Interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a. Glycobiology 2021;31(7):827-37. (*: equally contributed., †: double corresponding authors.)

14. Okazaki M, Mogushi K, Denda-Nagai K†, Fujihira H, Noji M, Ishii-Schrade K, Sakata-Matsuzawa M, Nakai K, Horimoto Y, Saito M, IrimuraT†. Biological and Clinicopathological Implications of Beta-3-N-acetylglucosaminyltransferase 8 in Triple-negative Breast Cancer. Anticancer Res 2021;41(2):848-858. (†: double corresponding authors.)

15. Kanemaru K, Noguchi E, Thara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A. Clc10a regulates mite-induced dermatitis. Sci Immunol 2019;4(42) eaax6908.

16. Yoshimura Y*, Denda-Nagai K*†, Takahashi Y, Nagashima I, Shimizu H, Kishimoto T, Noji M, Shichino S, Chiba Y, Irimura T†. Products of Chemoenzymatic Synthesis Representing MUC1 Tandem Repeat Unit with T-, ST- or STn-antigen Revealed Distinct Specificities of Anti-MUC1 Antibodies. Sci Rep 2019;9(1):16641. (*: equally contributed., †: double corresponding authors.)

17. Yoshimoto T, Matsubara D, Soda M, Ueno T, Amano Y, Kihara A, Sakatani T, Nakano T, Shibano T, Endo S, Hagiwara K, Fukayama M, Denda-Nagai K, Irimura T, Mano H, Niki T. Mucin 21 is a key molecule involved in the incohesive growth pattern in lung adenocarcinoma. Cancer Sci 2019;110(9):3006-3011.

18. Matsumura M, Okudela K, Nakashima Y, Mitsui H, Denda-Nagai K, Suzuki T, Arai H, Umeda S, Tateishi Y, Koike C, Kataoka T, Irimura T, Ohashi K. Specific expression of MUC21 in micropapillary elements of lung adenocarcinomas - Implications for the progression of EGFR-mutated lung adenocarcinomas. PLoS One 2019;14(4):e0215237.

19. Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T. A Critical Domain of Ebolavirus Envelope Glycoprotein Determines Glycoform and Infectivity. Sci Rep 2018;8:5495.

20. Ng WC, Liong S, Tate MD, Irimura T, Denda-Nagai K, Brooks AG, Londrigan SL, Reading PC. The macrophage galactose-type lectin can function as an attachment site and entry for influenza virus. J Virol. 2014;88(3):1659-72.

21. Murakami R*, Denda-Nagai K*†, Hashimoto S, Nagai S, Hattori M, Irimura T†. A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS One 2013;8(9):e73270. (*: equally contributed., †: double corresponding authors.)

22. Sugiura D, Denda-Nagai K†, Takashima M, Murakami R, Nagai S, Takeda K, Irimura T†. Local effects of regulatory T cells in MUC1 transgenic mice potentiate growth of MUC1 expressing tumor cells in vivo. PLoS One 2012;7(9):e44770. (†: double corresponding authors.)

23. Tian Y, Denda-Nagai K, Kamata-Sakurai M, Nakamori S, Tsukui T, Itoh Y, Okada K, Yi Y, Irimura T. Mucin 21in esophageal squamous epithelia and carcinomas: analysis with glycoform-specific monoclonal antibodies. Glycobiology 2012;22(9):1218-26.

24. Usami K, Matsuno K, Igarashi M, Denda-Nagai K, Takada A, Irimura T. Involvementof viral envelop GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin. Biochem Biophys Res Commun 2011;407(1):74-8.

25. Sugiura D, Denda-Nagai K, Takeda K, Irimura T. Organ microenvironment plays significant roles through Fas ligand in vccine-induced CD4(+) T cell dependent suppression of tumor growth at the orthotopic site. Cancer Sci 2010;101(9):1965-9.

26. Yi Y, Kamata-Sakurai M, Denda-Nagai K, Itoh T, Okada K, Ishii-Schrade K, Iguchi A, Sugiura D, Irimura T. Mucin 21/epiglycanin modulate cell adhesion. J Biol Chem 2010;285(28):21233-40.

27. Denda-Nagai K, Aida S, Saba K, Suzuki K, Moriyama S, Oo-Puthinan S, Tsuiji M, Morikawa A, Kumamoto Y, Sugiura D, Kudo A, Akimoto Y, Kawakami H, Bovin NV, Irimura T. Distribution and function of macriphage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. J Biol Chem 2010;285(25):19193-204.

28. Kumamoto Y, Denda-Nagai K, Aida S, Higashi N, Irimura T. MGL2+ dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo. PLoS One 2009;4(5):e5619.

29. Saba K, Denda-Nagai K, Irimura T. A C-type lectin MGL1/CD301a plays an anti-inflammatory role in murine experimental colitis. Am J Pathol 2009;174(1):144-52.

30. Sugiura D, Aida S, Denda-Nagai K, Takeda K, Kamata-Sakurai M, Yagita H, Irimura T. Differential effector mechanisms induced by vaccination with MUC1 DNA in the rejection of colon carcinoma growth at orthotopic sites and metastases. Cancer Sci 2008;99(12):2477-84.

31. Oo-Puthinan S, Maenuma K, Sakakura M, Denda-Nagai K, Tsuiji M, Shimada I, Nakamura-Tsuruta S, Hirabayashi J, Bovin NV, Irimura T. The amino acids involved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2 (CD301a and b) of mice. Biochim Biophys Acta 2008;1780(2):89-100.

32. Itoh Y, Kamata-Sakurai M, Denda-Nagai K, Nagai S, Tsuiji M, Ishii-Schrade K, Okada K, Goto A, Fukayama M, Irimura T. Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin. Glycobiology 2008;18(1):74-83.

33. Napoletano C, Rughetti A, Agervig Tarp MP, Coleman J, Bennett EP, Picco G, Sale P, Denda-Nagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M. Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells. Cancer Res 2007;67(17):8358-67.

34. Sano Y, Usami K, Izawa R, Denda-Nagai K, Higashi N, Kimura T, Suzuki N, Irimura T. Properties of blocking and non-blocking monoclonal antibodies specific for human macrophge galactose-type C-type lectin (MGL/ClecSF10A/CD301). J Biochem 2007;141(1):127-36.

35. Dupasquier M, Stoitzner P, Wan H, Cerqueira D, van Oudenaren A, Voerman JS, Denda-Nagai K, Irimura T, Raes G, Romani N, Leenen PJ. The dermal microenvironment incduces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes, independent of IL-4/IL-13 signaling. J Leukoc Biol 2006;80(4):838-49.

36. Kumamoto Y, Higashi N, Denda-Nagai K, Tsuiji M, Sato K, Crocker PR, Irimura T. Identification of sialoadhesin as a dominant lymph node counter-receptor for macrophage galactose-type C-type lectin 1. J Biol Chem 2004;279(47):49274-80.

37. Kamata M, Denda-Nagai K, Kubota N, Aida S, Takeda K, Irimura T. Vaccination of mice with MUC1 cDNA suppresses the development of lung metastases. Clin Exp Metastasis 2002;19(8):689-96.

38. Takeuchi H, Kato K, Denda-Nagai K, Hanisch FG, Clausen H, Irimura T. The epitope recognized by the unique anti-MUC1 monoclonal antibody MY.1E12 involves sialy alpha 2-3galactosyl beta 1-3N-acetylgalactosaminide linked to a distinct threonine residue in the MUC1 tandem repeat.
J Immunol Methods 2002;270(2):199-209.

39. Denda-Nagai K, Kubota N, Tsuiji M, Kamata M, Irimura T. Macrophage C-type lectin on bone marrow-derived immature dendritic cells is involved in the internalization of galactosylated antigens. Glycobiology 2002;12(7):443-50.

40. Higashi N, Fujioka K, Denda-Nagai K, Hashimoto S, Nagai S, Sato T, Fujita Y, Morikawa A, Tsuiji M, Miyata-Takeuchi M, Sano Y, Suzuki N, Yamamoto K, Matsushima K, Irimura T. The macrophage C-type lectin specific for galactose/N-acetylgalactosamine is an endocytic receptor expressed on monocyte-derived immature dendritic cells. J Biol Chem 2002;277(23):20686-93.

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伝田 香里（デンダ カオリ）

伝田香里（デンダカオリ）