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三高千恵子（ミタカチエコ）

研究テーマ	急性腎傷害、敗血症性ショック
研究業績（論文）	1. Mitaka C, Sakanishi N, Tsunoda Y, et al. Anesthetic management of congenital insensitivity to pain with anhydrous. Anesthesiology 63:328-329,1985 2. Mitaka C, Nagura T, Sakanishi N, et al. Two-dimentional echocardiographic evaluation of inferior vena cava, right ventricle, and left ventricle during positive-pressure ventilation with varying levels of positive end-expiratory pressure. Crit Care Med 17:205-210, 1989 3. Mitaka C, Nagura T, Sakanishi N, et al. Plasma alpha-atrial natriuretic peptide. concentration in acute respiratory failure with sepsis: preliminary study. Crit Care Med 18:1201-1203,1990 4. Mitaka C, Hirata Y, Nagura T, et al. Plasma alpha-human atrial natriuretic peptide in patients with acute lung injury. Am Rev Respir Dis 146:43-46, 1992 5. Mitaka C, Hirata Y, Makita K, et al. Endothelin-1 and atrial natriuretic peptide in septic shock. Am Heart J 126:466-468,1993 6. Mitaka C, Hirata Y, Nagura T, et al. Circulating endothelin-1 concentration in acute respiratory failure. Chest 104:476-480, 1993 7. Mitaka C, Hirata Y, Ichikawa K, et al. Effect of TNF-α on hemodynamic changes and circulating endothelium-derived vasoactive factors in dogs. Am J Physiol 267:H1530-H1536, 1994 8. Mitaka C, Hirata Y, Ichikawa K, et al. Effects of nitric oxide synthase inhibitor on hemodynamic changes and O2 delivery in septic shock dogs. Am J Physiol 268:H2017-H2023, 1995 9. Hirata Y, Mitaka C, Sato K, et al. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 81: 1449-1453, 1996 10. Mitaka C, Hirata Y, Ichikawa K, et al. Effect of aminoguanidine, a more selective inhibitor for inducible nitric oxide synthase, on cardiovascular changes in endotoxin shock dogs. Applied Cardiopulmonary Pathophysiology 6:145-150, 1996 11. Hirata Y, Mitaka C, Sato K, Nagura T, Tsunoda Y, Amaha K, Marumo F: Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 81: 1449-1453, 1996 11. Mitaka C, Hirata Y, Sato K, et al. C-type natriuretic peptide in sepsis. Intensive Care Med 23:354-355, 1997 12. Mitaka C, Hirata Y, Nagura T, et al. Increased plasma concentrations of brain natriuretic peptide in patients with acute lung injury. J Crit Care 12:66-71, 1997 13. Mitaka C, Hirata Y, Yokoyama K, et al. Beneficial effect of carboxy-PTIO on hemodynamic and blood gas changes in septic shock dogs. Crit Care 1:45-50, 1997 14. Mitaka C, Hirata Y, Yokoyama K, et al. Pathologic role of endothelin-1 in septic shock. J Cardiovascular Pharmacy 31(Suppl. I):S233-S235, 1998 15. Mitaka C, Hirata Y, Nagura T, et al. Beneficial effect of atrial natriuretic peptide on pulmonary gas exchange in patients with acute lung injury. Chest 114:223-228, 1998 16. Mitaka C, Hirata Y, Yokoyama K, et al. Improvement of renal dysfunction in dogs with endotoxemia by a non-selective endothelia receptor antagonist. Crit Care Med 27:146-153, 1999 17. Mitaka C, Hirata Y, Masaki Y, et al S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model. Intensive Care Med 26:117-124, 2000 18. Mitaka C, Hirata Y, Yokoyama K, et al. L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin concentrations in dogs with endotoxic shock. J Crit Care 16:17-23, 2001 19. Imai T, Mitaka C, Nosaka T, et al. Accuracy and repeatability of blood volume measurement by pulse dye densitometry compared to the conventional method using 51Cr-labeled red blood cells. Intensive Care Med 26: 1343-1349, 2000 20. Mitaka C, Hirata Y, Yokoyama K, et al. A selective inhibitor for inducible NO synthase improves hypotension and lactic acidosis in canine endotoxic shock. Crit Care Med 29: 2156-2161, 2001 21. Mitaka C, Hirata Y, Habuka K, et al. Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema. Crit Care Med 30: 1570-1575, 2002 22. Mitaka C, Yokoyama K, Morimoto T, et al. An increase in urinary nitrite/nitrate excretion is associated with the hyperdynamic state after cardiovascular surgery. Intensive Care Med 28: 1103-1109, 2002 23. Mitaka C, Hirata Y, Yokoyama K, et al. Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome. Shock19: 305-309, 2003 24. Mitaka C, Hirata Y, Habuka K, et al. Atrial natriuretic peptide infusion improves ischemic renal failure after suprarenal abdominal aortic cross-clamping in dogs. Crit Care Med 31: 2205-2210, 2003 25. Mitaka C, Hirata Y, Narumi Y, Yokoyama K, Makita K, Katsuyama K, Imai T: Blockade of nuclear factor-kB activation prevents hypodynamic shock and gastric hypoperfusion induced by endotoxin in anesthetized dogs. Intensive Care Medicine 31: 718-723, 2005 26. Mitaka C: Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clinica Chimica Acta 351: 17-29, 2005 27. Mitaka C, Yokoyama K, Imai T: Nitric oxide production is more prominent in off-pump than in on-pump coronary artery bypass surgery. Anaesth Intensive Care 35: 505-509, 2007 28. Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T: Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. Crit Care Med 36: 745-751, 2008 29. Mitaka C, Tsuchida N, Kawada K, Nakajima Y, Imai T, Sasaki S: A longer duration of polymyxin B-immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock. Shock 32: 478-483, 2009 30. Mitaka C, kudo T, Haraguchi G, Tomita M: Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis. Crit Care 15:R258, 2011 31. Mitaka C, Tomita M: Polymyxin B-immobilized column hemoperfusion therapy for septic shock. Shock 36: 332-338, 2011 32. Hnin Si MK, Mitaka C, Tulafu M, et al. Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats. Respir Res 14: 126, 2013 33. Tulafu M, Mitaka C, Hnin Si MK, et al. Atrial natriuretic peptide attenuates kidney-lung crosstalk in kidney injury. J Surg Res 186: 217-225, 2014 34. Zhao D, Zhou J, Haraguchi G, Arai H, Mitaka C. Procalcitonin for the differential diagnosis of infectious and non-infectious systemic inflammatory response syndrome after cardiac surgery. J Intensive Care 2: 35, 2014 35. Mitaka C, Hnin Si MK, Tulafu M, et al. Qi Y, Uchida T, Abe S, Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury. Intensive Care Medicine Experimental,2,28-44,2014 36. Mitaka C, Fujiwara N, Yamamoto M, et al.: Polymyxin B-immobilized fiber column hemoperfusion removes endotoxin throughout a 24-hour treatment period. J Critical Care 29: 728-732, 2014 37. Mitaka C, Hnin Si MK, Tulafu M, et al.: Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury. Intensive Care Medicine Experimental 2: 28, 2014 38. Sugiura M, Mitaka C, Haraguchi G, et al.: Polymyxin B-immobilized fiber column hemoperfusion maily helps to constrict peripheral blood vessels in treatment for septic shock. J Intensive Care 2015;3:14 39. Mitaka C, Masuda T, Kido K, et al.: Polymyxin B hemoperfusion prevents acute kidney injury in sepsis model. J Surg Res 201:59-68, 2016 40. Mitaka C, Ohnuma T, Murayama T, et al. Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury: A multi center randomized controlled trial. J Crit Care38:253-258, 2017 41. Furusawa H, Sugiura M, Mitaka C, et al. Direct hemoperfusion with polymyxin B-immobilized fibre treatment for acute exacerbation of interstitial pneumonia. Respirology 22:1357-1362, 2017 42. Mitaka C, et al. High-flow oxygen via tracheostomy facilitates weaning from prolonged mechanical ventilation in patients with restrictive pulmonary dysfunction:two cases reports. Journal of Medical Case Reports 12:292,2018 43. Mitaka C, Ishibashi C, Kawagoe I, et al. Correlation between urinary biomarker and organ failure in patients with sepsis and patients after esophagectomy: a prospective observational study. J Intensive Care 8:11, 2020 44. Mitaka C, Kusaoi M, Kawagoe I, Satoh D. Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock. Acute and Critical Care 2021: 36(2):85-91. 45. Mitaka C, Kawagoe I, Satoh D, Hayashida M.et al. Effect of recombinant human soluble thrombomodulin on coagulation-related variables in patients with sepsis-induced disseminated intravascular coagulation: a retrospective observational study. Clinical App Thromb Hemost. 2021;27:1-7. Doi:10.1177/10760296211050356 46. Satoh D, Mitaka C, Okazaki A, Koh K, Kawagoe I, Hashimoto T, Hayashida M. Effects of nasal high-flow therapy after open chest esophagectomy for esophageal cancer. J Surg 2021;6:1369. DOI:10.29011/2575-9760.001369 47. Mitaka C, Kusaoi M, Kawagoe I, Satoh D, Iba T. Impact of extended duration of polymyxin B-immobilized fiber column direct hemoperfusion on hemodynamics, vasoactive substance requirement, and pulmonary oxygenation in patients with sepsis: an observational study. Blood Purif 2022:51:62-69. DOI:10.1159/000515685 48. Niimi N, Taga K, Miyazaki T, Naito T, Mitaka C. Rhabdomyolysis secondary to hypervirulent Klebsiella Pneumoniae infection: A case report. Clin Case Rep 2022:10:e6754 49. Mitaka C, Teranishi K, Wakita M, Misawa S, Nojiri S, Satoh D, Hayashida M. Incidences of and risk factors for clinical and subclinical contrast-associated acute kidney injury in patients who underwent neuroendovascular surgery. Neuroradiol J. 2023 Apr 27; 19714009231173104. DOI:10.1177/19714009231173104 50. Hasegawa A, Niimi N, Mitaka C, Hayashida M. Negative pressure pulmonary edema due to upper airway obstruction after general anesthesia in a patient with Parkinson's disease: A case report. Clin Case Rep 2023;11:e7444

研究テーマ

急性腎傷害、敗血症性ショック

研究業績（論文）

1. Mitaka C, Sakanishi N, Tsunoda Y, et al. Anesthetic management of congenital insensitivity to pain with anhydrous. Anesthesiology 63:328-329,1985

2. Mitaka C, Nagura T, Sakanishi N, et al. Two-dimentional echocardiographic evaluation of inferior vena cava, right ventricle, and left ventricle during positive-pressure ventilation with varying levels of positive end-expiratory pressure. Crit Care Med 17:205-210, 1989

3. Mitaka C, Nagura T, Sakanishi N, et al. Plasma alpha-atrial natriuretic peptide. concentration in acute respiratory failure with sepsis: preliminary study. Crit Care Med 18:1201-1203,1990

4. Mitaka C, Hirata Y, Nagura T, et al. Plasma alpha-human atrial natriuretic peptide in patients with acute lung injury. Am Rev Respir Dis 146:43-46, 1992

5. Mitaka C, Hirata Y, Makita K, et al. Endothelin-1 and atrial natriuretic peptide in septic shock. Am Heart J 126:466-468,1993

6. Mitaka C, Hirata Y, Nagura T, et al. Circulating endothelin-1 concentration in acute respiratory failure. Chest 104:476-480, 1993

7. Mitaka C, Hirata Y, Ichikawa K, et al. Effect of TNF-α on hemodynamic changes and circulating endothelium-derived vasoactive factors in dogs. Am J Physiol 267:H1530-H1536, 1994

8. Mitaka C, Hirata Y, Ichikawa K, et al. Effects of nitric oxide synthase inhibitor on hemodynamic changes and O2 delivery in septic shock dogs. Am J Physiol 268:H2017-H2023, 1995

9. Hirata Y, Mitaka C, Sato K, et al. Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 81: 1449-1453, 1996

10. Mitaka C, Hirata Y, Ichikawa K, et al. Effect of aminoguanidine, a more selective inhibitor for inducible nitric oxide synthase, on cardiovascular changes in endotoxin shock dogs. Applied Cardiopulmonary Pathophysiology 6:145-150, 1996

11. Hirata Y, Mitaka C, Sato K, Nagura T, Tsunoda Y, Amaha K, Marumo F: Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 81: 1449-1453, 1996

11. Mitaka C, Hirata Y, Sato K, et al. C-type natriuretic peptide in sepsis. Intensive Care Med 23:354-355, 1997

12. Mitaka C, Hirata Y, Nagura T, et al. Increased plasma concentrations of brain natriuretic peptide in patients with acute lung injury. J Crit Care 12:66-71, 1997

13. Mitaka C, Hirata Y, Yokoyama K, et al. Beneficial effect of carboxy-PTIO on hemodynamic and blood gas changes in septic shock dogs. Crit Care 1:45-50, 1997

14. Mitaka C, Hirata Y, Yokoyama K, et al. Pathologic role of endothelin-1 in septic shock. J Cardiovascular Pharmacy 31(Suppl. I):S233-S235, 1998

15. Mitaka C, Hirata Y, Nagura T, et al. Beneficial effect of atrial natriuretic peptide on pulmonary gas exchange in patients with acute lung injury. Chest 114:223-228, 1998

16. Mitaka C, Hirata Y, Yokoyama K, et al. Improvement of renal dysfunction in dogs with endotoxemia by a non-selective endothelia receptor antagonist. Crit Care Med 27:146-153, 1999

17. Mitaka C, Hirata Y, Masaki Y, et al S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model. Intensive Care Med 26:117-124, 2000

18. Mitaka C, Hirata Y, Yokoyama K, et al. L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin concentrations in dogs with endotoxic shock. J Crit Care 16:17-23, 2001

19. Imai T, Mitaka C, Nosaka T, et al. Accuracy and repeatability of blood volume measurement by pulse dye densitometry compared to the conventional method using 51Cr-labeled red blood cells. Intensive Care Med 26: 1343-1349, 2000

20. Mitaka C, Hirata Y, Yokoyama K, et al. A selective inhibitor for inducible NO synthase improves hypotension and lactic acidosis in canine endotoxic shock. Crit Care Med 29: 2156-2161, 2001

21. Mitaka C, Hirata Y, Habuka K, et al. Atrial natriuretic peptide improves pulmonary gas exchange by reducing extravascular lung water in canine model with oleic acid-induced pulmonary edema. Crit Care Med 30: 1570-1575, 2002

22. Mitaka C, Yokoyama K, Morimoto T, et al. An increase in urinary nitrite/nitrate excretion is associated with the hyperdynamic state after cardiovascular surgery. Intensive Care Med 28: 1103-1109, 2002

23. Mitaka C, Hirata Y, Yokoyama K, et al. Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome. Shock19: 305-309, 2003

24. Mitaka C, Hirata Y, Habuka K, et al. Atrial natriuretic peptide infusion improves ischemic renal failure after suprarenal abdominal aortic cross-clamping in dogs. Crit Care Med 31: 2205-2210, 2003

25. Mitaka C, Hirata Y, Narumi Y, Yokoyama K, Makita K, Katsuyama K, Imai T: Blockade of nuclear factor-kB activation prevents hypodynamic shock and gastric hypoperfusion induced by endotoxin in anesthetized dogs. Intensive Care Medicine 31: 718-723, 2005

26. Mitaka C: Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clinica Chimica Acta 351: 17-29, 2005

27. Mitaka C, Yokoyama K, Imai T: Nitric oxide production is more prominent in off-pump than in on-pump coronary artery bypass surgery. Anaesth Intensive Care 35: 505-509, 2007

28. Mitaka C, Kudo T, Jibiki M, Sugano N, Inoue Y, Makita K, Imai T: Effects of human atrial natriuretic peptide on renal function in patients undergoing abdominal aortic aneurysm repair. Crit Care Med 36: 745-751, 2008

29. Mitaka C, Tsuchida N, Kawada K, Nakajima Y, Imai T, Sasaki S: A longer duration of polymyxin B-immobilized fiber column hemoperfusion improves pulmonary oxygenation in patients with septic shock. Shock 32: 478-483, 2009

30. Mitaka C, kudo T, Haraguchi G, Tomita M: Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis. Crit Care 15:R258, 2011

31. Mitaka C, Tomita M: Polymyxin B-immobilized column hemoperfusion therapy for septic shock. Shock 36: 332-338, 2011

32. Hnin Si MK, Mitaka C, Tulafu M, et al. Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates lung-kidney crosstalk induced by intratracheal lipopolysaccharide instillation in rats. Respir Res 14: 126, 2013

33. Tulafu M, Mitaka C, Hnin Si MK, et al. Atrial natriuretic peptide attenuates kidney-lung crosstalk in kidney injury. J Surg Res 186: 217-225, 2014

34. Zhao D, Zhou J, Haraguchi G, Arai H, Mitaka C. Procalcitonin for the differential diagnosis of infectious and non-infectious systemic inflammatory response syndrome after cardiac surgery. J Intensive Care 2: 35, 2014

35. Mitaka C, Hnin Si MK, Tulafu M, et al. Qi Y, Uchida T, Abe S, Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury. Intensive Care Medicine Experimental,2,28-44,2014

36. Mitaka C, Fujiwara N, Yamamoto M, et al.: Polymyxin B-immobilized fiber column hemoperfusion removes endotoxin throughout a 24-hour treatment period. J Critical Care 29: 728-732, 2014

37. Mitaka C, Hnin Si MK, Tulafu M, et al.: Effects of atrial natriuretic peptide on inter-organ crosstalk among the kidney, lung, and heart in a rat model of renal ischemia-reperfusion injury. Intensive Care Medicine Experimental 2: 28, 2014

38. Sugiura M, Mitaka C, Haraguchi G, et al.: Polymyxin B-immobilized fiber column hemoperfusion maily helps to constrict peripheral blood vessels in treatment for septic shock. J Intensive Care 2015;3:14

39. Mitaka C, Masuda T, Kido K, et al.: Polymyxin B hemoperfusion prevents acute kidney injury in sepsis model. J Surg Res 201:59-68, 2016

40. Mitaka C, Ohnuma T, Murayama T, et al. Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery-associated acute kidney injury: A multi center randomized controlled trial. J Crit Care38:253-258, 2017

41. Furusawa H, Sugiura M, Mitaka C, et al. Direct hemoperfusion with polymyxin B-immobilized fibre treatment for acute exacerbation of interstitial pneumonia. Respirology 22:1357-1362, 2017

42. Mitaka C, et al. High-flow oxygen via tracheostomy facilitates weaning from prolonged mechanical ventilation in patients with restrictive pulmonary dysfunction:two cases reports. Journal of Medical Case Reports 12:292,2018

43. Mitaka C, Ishibashi C, Kawagoe I, et al. Correlation between urinary biomarker and organ failure in patients with sepsis and patients after esophagectomy: a prospective observational study. J Intensive Care 8:11, 2020

44. Mitaka C, Kusaoi M, Kawagoe I, Satoh D. Up-to-date information on polymyxin B-immobilized fiber column direct hemoperfusion for septic shock. Acute and Critical Care 2021: 36(2):85-91.

45. Mitaka C, Kawagoe I, Satoh D, Hayashida M.et al. Effect of recombinant human soluble thrombomodulin on coagulation-related variables in patients with sepsis-induced disseminated intravascular coagulation: a retrospective observational study. Clinical App Thromb Hemost. 2021;27:1-7. Doi:10.1177/10760296211050356

46. Satoh D, Mitaka C, Okazaki A, Koh K, Kawagoe I, Hashimoto T, Hayashida M. Effects of nasal high-flow therapy after open chest esophagectomy for esophageal cancer. J Surg 2021;6:1369. DOI:10.29011/2575-9760.001369

47. Mitaka C, Kusaoi M, Kawagoe I, Satoh D, Iba T. Impact of extended duration of polymyxin B-immobilized fiber column direct hemoperfusion on hemodynamics, vasoactive substance requirement, and pulmonary oxygenation in patients with sepsis: an observational study. Blood Purif 2022:51:62-69. DOI:10.1159/000515685

48. Niimi N, Taga K, Miyazaki T, Naito T, Mitaka C. Rhabdomyolysis secondary to hypervirulent Klebsiella Pneumoniae infection: A case report. Clin Case Rep 2022:10:e6754

49. Mitaka C, Teranishi K, Wakita M, Misawa S, Nojiri S, Satoh D, Hayashida M. Incidences of and risk factors for clinical and subclinical contrast-associated acute kidney injury in patients who underwent neuroendovascular surgery. Neuroradiol J. 2023 Apr 27; 19714009231173104. DOI:10.1177/19714009231173104

50. Hasegawa A, Niimi N, Mitaka C, Hayashida M. Negative pressure pulmonary edema due to upper airway obstruction after general anesthesia in a patient with Parkinson's disease: A case report. Clin Case Rep 2023;11:e7444

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【学校法人順天堂】研究者情報データベース

研究業績詳細

三高 千恵子（ミタカ チエコ）

三高千恵子（ミタカチエコ）