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和田裕雄（ワダヒロオ）

研究テーマ	呼吸器病学、加齢医学、産業医学、公衆衛生学、睡眠予防医学
研究業績（論文）	〈日本語原著・総説〉 1.久田剛志、西村泰光、土橋邦生、吉田貴彦、伊藤俊弘、森本泰夫、菅沼成文‌、李卿、和田裕雄、上田厚、香山不二雄‌、佐藤一博、佐藤実、柴田英治、竹下達也、柳澤裕之、角田正史、日本産業衛生学会アレルギー免疫毒性研究会．予防・臨床医学理論と実践体系におけるアレルギー・免疫毒性制御２．現代社会を取り巻く環境因子と気管支喘息発症メカニズム．産業衛生学雑誌2024, in press 2.和田裕雄、白濱龍太郎、植田結人、細川まゆ子、津田徹、谷川武．職域における睡眠・休養の問題「長時間労働の医師への健康確保措置に関するマニュアル」作成の科学的背景. 産業衛生学雑誌 2024, 66: 202-206. 3.和田裕雄、植田結人、谷川武．医師の働き方改革における追加的健康確保措置．医学のあゆみ 2023; 287:596-600 4.和田裕雄、今中雄一、磯博康．厚労省科学研究における調査から：VUCA時代に求められる公衆衛生人材．公衆衛生 2023; 87 (9): 881-889. 5.和田裕雄、安田行宏．健康経営と企業パフォーマンスに関する論点整理．証券アナリストジャーナル 2023;61 (7):18-30. 6.和田裕雄、谷川武. 睡眠時無呼吸症候群が社会に与える影響. 耳鼻咽喉科・頭頸部外科2023; 95(4): 299-304. 7.土橋邦生、吉田貴彦、森本泰夫、上田厚、伊藤俊弘、和田裕雄、香山不二雄、佐藤一博、佐藤実、柴田英治、菅沼成文、竹下達也、角田正史、西村泰光、柳澤裕之、李卿、日本産業衛生学会アレルギー免疫毒性研究会．予防・臨床医学理論と実践体系におけるアレルギー・免疫毒性制御　職業アレルギーとイソシアネート喘息．産業衛生学雑誌2023; 65: 1-8. 8.和田裕雄、谷川武. 睡眠時無呼吸症候群 (SAS) の疫学. 呼吸器内科　2022、41.4: 320-325. 9.稲垣暢也、磯博康、今中雄一、永井良三、杉山雄大、亀田義人、平木秀輔、和田裕雄、高野彩佳、飯島由佳、村越和輝.合同シンポジウム臨床医学と社会医学の未来. 日本内科学会雑誌2022; 111(9): 2004-2028. 10.和田裕雄、谷川武．高齢者の睡眠時無呼吸．老年内科2021; 4: 583-588. 11.和田裕雄、谷川武．ひとくちメモ：睡眠呼吸障害と運転のリスク．日本医師会雑誌2020; 149: 272. 12.和田裕雄, 谷川武．睡眠の諸問題　連載を終えるに当たって．公衆衛生2020; 84: 480-484. 13.和田裕雄、木村真奈美、谷川武. OSAとCSAの頻度. 呼吸器ジャーナル 2019; 67: 406-413. 14.和田裕雄、白濱龍太郎、津田徹、谷川武、職域における睡眠呼吸障害研究会．職域における睡眠呼吸障害と健康経営.日本産業衛生学雑誌. 2019; 61: 89-94. 15.和田裕雄、横山和仁．臨床医学の「診療」と社会医学の「実践」の接点．保健の科学 2018; 60: 465-470. 16.和田裕雄、谷川武．検査室外睡眠検査（OCST）の現状と適正使用．睡眠医療 2016; 36: 511-517. 17.和田裕雄、COPDの一次予防．呼吸器内科 2016; 30: 463-472. 18.和田裕雄、谷川武．睡眠呼吸障害の疫学．MB Medical Rehabilitation 2016; 203: 90-97. 19.和田裕雄、谷川武．睡眠障害と交通事故． Progress Med 2016; 36: 511-517. 〈英文原著・総説〉 1. Hamada S, Ueki J, Hirai T, Sano E, Hino K, Ikeda M, Sato S, Oga T, Tsuboi T, Kurosawa H, Wada H, On behalf of the Japanese White Paper on Home Respiratory Care 2024 working group. Current status and regional differences in disaster planning and preparedness for long-term oxygen therapy: The Japanese White Paper on Home Respiratory Care 2024. Respir Investig 2025, in press 2. Takeyama E, Tomooka K, Kunimatsu-Sanuki S, Sato S, Sakiyama N, Wada H, Matsumoto C. Tanigawa T. The association between self-checked visual field impairment and motor vehicle accidents among Japanese taxi drivers. Sci Rep 2025, in press 3. Yaegashi T, Wada H, Ueda Y, Zhu Q, Maruyama K, Kameda Y, Shirahama R, Ikeda A, Nakano H, Tanigawa T. Association between Asthma and Sleep-Disordered Breathing in Elementary School Children in Japan. Sleep Med 2025, in press 4. Zhu Q, Wada H, Ueda Y, Onuki K, Miyakawa M, Sato S, Kameda Y, Matsumoto F, Inoshita A, Nakano H, Tanigawa T. Association between subjective sleepiness and vigilant attention in elementary school students. Sleep Health 2025, in press. 5. Watanabe R, Ikeda A, Charvat H, Sato S, Suzuki Y, Maruyama K, Tomooka K, Wada H, Koyama Y, Tanigawa T. Association between levels of satisfaction with interpersonal relationships and insomnia symptoms among women working in aged-care services in Japan. Environ Health Prev Med. 2025; 30: 47. 6. Furuya R, Wada H, Onuki K, Kitazawa T, Miyakawa M, Zhu Q, Ueda Y, Sato S, Nakano H, Gozal D, Tanigawa T. Association between insufficient aleep and constipation among elementary school children in Japan. Sleep Biol Rhythms. 2025, in press 7. Hamada S, Ueki J, Hirai T, Sano E, Hino K, Ikeda M, Sato S, Oga T, Tsuboi T,　Kurosawa H, Wada H, on behalf of the Japanese White Paper on Home Respiratory Care 2024 working group. Current trends in long-term oxygen therapy and home mechanical ventilation: a summary of the Japanese White Paper on Home Respiratory Care 2024. Respir Investig 2025, in press. 8. Wada H, Basner M, Cordoza M, Dinges D, Tanigawa T. Objective alertness, rather than sleep duration, is associated with burnout and depression: a national survey of Japanese physicians. J Sleep Res 2025; 34(1): e14304. 9. Iwata K, Sato M, Yoshida S, Wada H, Sekimizu K, Okazaki M. Histopathological analysis of filament formation of Nocardia farcinica in a silkworm infection model. Drug Discov Ther 2024; 18(5): 290-295. 10. Petrarca C, Viola D, Resta A, Di Giampaolo L, Wada H. Asbestos-related and non-communicable diseases in formerly exposed workers: relationship with residential asbestos, smoke and business sector. J Community Med Pub Health 2024; 8: 450. doi.org/10.29011/2577-2228.100450. 11. Wada H, Basner M, Cordoza M, Dinges D, Tanigawa T. Objective alertness, rather than sleep duration, is associated with burnout and depression: a national survey of Japanese physicians. J Sleep Res 2024: e14304. doi: 10.1111/jsr.14304. 12. Matsuura Y, Tomooka K, Wada H, Sato S, Endo M, Taneda K, Tanigawa T. The association of long working hours and short sleep duration on mental health among Japanese physicians. Ind Health. 2024 in press. doi:10.2486/indhealth.2023-0174. 13. Zhu Q, Wada H, Ueda Y, Onukia K, Miyakawa M, Sato S, Kameda Y, Matsumoto F, Inoshita A, Nakano H, Tanigawa T. Association between habitual snoring and vigilant attention in elementary school children. Sleep Med. 2024; 118: 9-15. 14. Wada H, Nakano H, Sakurai S, Tangiawa T. Self-reported Sleep Tendency Poorly Predicts the Presence of Obstructive Sleep Apnea in Commercial Truck Drivers. Sleep Med. 2024; 115: 109-113. 15. Koike S, Wada H, Ohde S, Ide H, Taneda K, Tanigawa T. Working hours of full-time hospital physicians in Japan: a cross-sectional nationwide survey. BMC Public Health. 2024; 24(1): 164. doi: 10.1186/ s12889-023-17531-5. 16. Kitazawa T, Wada H, Onuki K, Furuya R, Miyakawa M, Zhu Q, Ueda Y, Sato S, Kameda Y, Nakano H, Gzoazl D, Tanigawa T. Snoring, obstructive sleep apnea and upper respiratory tract infection in elementary school children in Japan. Sleep Breath. 2023; 10.1007/s11325-023-02932-y 17. Kimura T, Kawano H, Muto S, Muramoto N, Takano T, Lu Y, Eguchi H, Wada H, Okazaki Y, Ide H, Horie S. PKD1 mutation is a biomarker for autosomal dominant polycystic kidney disease. Biomolecules 2023; 13(7): 1020. doi: 10.3390/biom13071020. 18. Nishizaki Y, Kuroki H, Ishii S, Ohtsu S, Watanabe C, Nishizawa H, Nagao M, Nojima M, Watanabe R, Sato D, Sato K, Kawata Y, Wada H, Toyoda G, Ohbayashi K.. Determining Optimal Intervals for In-Person Visits During Video-Based Telemedicine Among Patients With Hypertension: Cluster Randomized Controlled Trial. JMIR Cardio. 2023; 7: e45230. 19. Zhu Q, Wada H, Onuki K, Kitazawa T, Furuya R, Miyakawa M, Sato S, Yonemoto N, Ueda Y, Nakano H, Gozal D, Tanigawa T. Validity and reliability of the Japanese version of the severity hierarchy score for pediatric obstructive sleep apnea screening. Sleep Med 2023; 101: 357-364. 20. Matsuo R, Tanigawa T, Oshima A, Tomooka K, Ikeda A, Wada H, Maruyama K, Saito I. Decreased psychomotor vigilance is a risk factor for motor vehicle crashes irrespective of subjective daytime sleepiness: the Toon Health Study. J Clin Sleep Med. 2023; 19(2): 319-325. 21. Wada H, Yasuda Y. Value Effect of Health and Productivity Management: An Event Study of the HPM Award in Japan. J Occup Environ Med. 2022; 64(6): 465-469. 22. Wada H, Nakamura M, Inoue SI, Kudo A, Hanawa T, Iwakura Y, Kobayashi F, Kamma H, Kamiya S, Ito K, Barnes PJ, Takizawa H. Dual Interleukin-17A/F Deficiency Protects against Acute and Chronic Response to Cigarette Smoke Exposure in Mice. Sci Rep 2021, 11: 11508. doi: 10.1038/s41598-021-90853-9. 23. Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H. Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort, The JACC Study. Sci Rep 2021; 11: 1531. doi: 10.1038/s41598-020-79860-4. 24. Wada H, Kondo K, Tanigawa T. Snoring is a pathogenic symptom: A need for its objective assessment. Geriatr Gerontol Int. 2020; 20(6): 648-649. 25. Wada H, Furuya S, Maruyama K, Ikeda A, Kondo K, Tanigawa T, on behalf of JAGES group. The prevalence and clinical impact of snoring in older community-dwelling adults. Geriatr Gerontol Int 2019; 19: 1165-1171. 26. Wada H, Kimura M, Shiarahama R, Ikeda A, Gozal D, Tanigawa T. Pectus excavatum is associated with sleep-related breathing disorders in children. Eur Respir J 2019; 54: pii: 1900524. 27. Wada H, Nagata K, Shirahama R, Tajima T, Kimura M, Ikeda A, Maruayma K, Tamura M, Suzuki K, Tanigawa T. The impact of sleep disordered breathing on performance in Judo players. BMJ Open Sport Exerc Med 2019; 5: e000418. (Official Journal of British Association of Sport and Exercise Medicine.) 28. Wada H, Fukumoto S, Tamamura K, Muto G, Ueki J, Tanigawa T. Toward the harmonization of work with treatment and prevention for patients with chronic respiratory failure. Ind Health 2019; 57: 84-89. 29. Wada H, Kimura M, Shirahama R, Tajima T, Maruyama K, Endo M, Ikeda A, Tanigawa T. Harmonizing work with the treatment and prevention of sleep disordered breathing in commercial motor vehicle drivers: implications for Health and Productivity Management. Ind Health 2019; 57: 3-9. 30. Wada H, Kimura M, Tajima T, Shirahama R, Suzuki Y, Suzuki Y, Hayashi T, Maruyama K, Endo M, Sakamoto N, Ikeda A, Gozal D, Tanigawa T. Nocturnal enuresis and sleep disordered breathing in primary school children: potential implications. Pediatir Pulm 2018, 53: 1541-1548. 31. Wada H, Shirahama R, Kimura M, Tajima T, Inoshita A, Tanigawa T. Sleep Disordered Breathing in Children. Juntendo Med J 2017; 63: 443-448. 32. Wada H, Ikeda A, Kales SA, Tanigawa T. Screening for sleep disordered breathing (SDB) in truck drivers in the US. Juntendo Med J 2015; 61: 350-351. 33. Wada H, Inui T, Nakamoto K, Sada M, Nakamura M, Takizawa H. A pivotal Role of Nrf2 in Airway Inflammatory Responses Inducedby Diesel Exhaust in Asthma: Mechanisms and Their Application to Clinical Interventions. 2015 in press. 34. Wada H, Akiyama Y, Takeda H, Nakamura M, Takizawa H. Social isolation in patients with chronic respiratory failure (CRF), undergoing long-term oxygen therapy (LTOT). J Am Geriatr Soc 2014; 62: 1807-1808. 35. Wada H, Hagiwara S, Yamamoto Y and Takizawa H. Links between lung dysfunction and glucose metabolism dysregulation: does lung dysfunction represent a systemic disorder? Intern Med 2014; 53; 2413-2414. 36. Kobayashi Y, Wada H, Rossios C, Takagi D, Charron C, Barnes PJ and Ito K. “A novel macrolide/fluoroketolide, splithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition",　Br J Pharmacol 2013; 169: 1024-1034. 37. Koybayashi Y, Wada H, Rossios C, Takagi D, Higaki M, Mikura S, Goto H and Barnes PJ. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-B inhibition. J Pharmacol Exp Ther 2013; 345: 76-85. [doi: 10.1124/jpet.112.200733.] 38. Yasutake T, Wada H, Higaki M, Nakamura M, Honda K, Watanabe M, Ishii H, Kamiya S, Takizawa H, and Goto H. Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549. F1000Research 2013, 2: 78 [doi: 10.12688/f1000research. 2-78.v1]. 39. Wada H and Takizawa H. Future Treatment for COPD: targeting oxidative stress and its related signal. Recent Pat Inflamm Allergy Drug Discov 2013; 7: 1-11.[ doi: 10.2174/1872213X11307010001] 40. Ohnishi H, Yonetani S, Matsushima S, Wada H, Takeshita K, Kuramochi D, De Souza PC, Campos CED, Da Costa BP, Ramos JP, Mikura S, Narisawa E, Fujita A, Funayama Y, Kobashi Y, Sakakibara Y, Ishiyama Y, Takakura S, Goto H, Watanabe T. Mycobacterium kyorinense Infection: Clinical Features and Antimicrobial Susceptibility. Emerg Infect Dis 2013; 19: 508-510.[ doi: 10.3201/eid1903.120591] 41. 1Hiraoka S, Wada H, MoritaK, Honda K, Koyanagi M, Y okoyama K, Fukuchi Y, Nitatori T, Goto H. Pulmonary volumetric analyses based on three-dimensional computed tomography (3D-CT), compared with pulmonary function test. Jpn J Diagn Imaging 2012; 30: 145-155. (*equal contribution to this publication.) 42. Wada H, Hagiwara S, Saitoh E, Ieki R, Yamamoto Y, Adcock IM and Goto H. Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease (COPD). BioMarkers 2012; 17: 520-523. [doi: 10.3109/1354750X.2012.692393.] 43. Watanabe A, Goto H, Soma K, Kikuchi T, Gomi K, Miki H, Maemondo M, Ikeda H, Kuroki J, Wada H, Yokoyama T, Izumi S, Mitsutake K and Ueda Y “Usefulness of linezolid in the treatment of hospital-acquired pneumonia caused by MRSA: a prospective observational study” J Infect Chemother 2012; 18: 160-168. 44. Saraya T, Nakata K, Nakagaki K, Motoi N, Iihara K, Fujioka Y, Oka T, Kurai D, Wada H, Ishii H, Taguchi H, Kamiya S and Goto H. “Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.” Results in Immunology 2011; 1: 76-87. 45. Mikura S, Wada H, Okazaki M, Nakamura M, Honda K, Yasutake T, Higaki M, Ishii T, Watanabe T, Tsunoda T and Goto H. “Risk factors for bacteraemia attributable to Pseudomonas aeruginosa resistant to imipenem, levofloxacin, or gentamicin.” J Hosp Infect 2011; 79: 267-268. 46. Takata S, Wada H, Tamura M, Koide T, Higaki M, Mikura S, Yasutake T, Hirao S, Nakamura M, Honda K, Nagatomo T, Tanaka Y, Watanabe M, Yokoyama T, Saraya T, Kurai D, Ishii H and Goto H. "Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community acquired pneumonia (CAP), as presented with biologic half-life times.” BioMarkers 2011; 16: 530-535. 47. Ohshima N, Matsui H, Matsui Y, Kawashima M, Shimada M, Higaki N, Shoji S, Wada H, Fujita A, Watanabe H, Yamaguchi N, Matsuoka R, Oki K, Takahashi H, Suzuki M, Yamazaki H , Yoshizawa M and Goto H “Addition of leukotriene receptor antagonists to inhaled corticosteroids improved QOL of patients with bronchial asthma surveyed in suburban Tokyo, Japan.” Allergol Int 2011; 60: 473-481. 48. Hirao S, Wada H, Nakagaki K, Saraya T, Kurai D, Mikura S, Yasutake T, Higaki M, Yokoyama T, Ishii H, Nakata K, Akashi T, Kamiya S and Goto H. “Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone” FEMS Immunology & Medical Microbiology 2011; 62: 182-189. 49. Mikura S, Wada H, Higaki M, Yasutake T, Ishii H, Kamiya S and Goto H “Erythromycin prevents the pulmonary inflammation induced by exposure to cigarette smoke” Transl Res 2011; 158: 30-37. 50. Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Goto H, Bemis JE, Elliott P, Barnes PJ and Ito K “A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9” FASEB J 2009; 23: 2810-2819 51. Wada H, Yamamoto M, Okazaki M, Watanabe T and Goto H. Isolation of Mycobacterium kyorinense in a patient with respiratory failure. Ann Intern Med 2009; 150: 568-570 52. Wada H, Hagiwara S, Goto H and Yamamoto Y, The redox status of coenzyme Q10 associated to the chronological age. J Am Geriatrics Soc 2007; 55: 1141-1142. 53. Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Iguchi M, Yuasa K, Kodaka T, Koishi T, Yamamoto Y and Goto H. Increased oxidative stress in patients with chronic obstructive pulmonary disesase (COPD) as measured by redox status of plasma coenzyme Q10. Pathophysiology 2006; 13: 29-33. 54. Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Kodaka T, Yamamoto Y and Goto H. Reduction in Plasma Free Fatty Acid in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2005; 171: 1465. 55. Wada H, Kagoshima M, Ito K, Barnes PJ and Adcock IM. 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene. Biochem Biophys Res Comm 2005; 331: 93-99.

研究テーマ

呼吸器病学、加齢医学、産業医学、公衆衛生学、睡眠予防医学

研究業績（論文）

〈日本語原著・総説〉
1.久田剛志、西村泰光、土橋邦生、吉田貴彦、伊藤俊弘、森本泰夫、菅沼成文‌、李卿、和田裕雄、上田厚、香山不二雄‌、佐藤一博、佐藤実、柴田英治、竹下達也、柳澤裕之、角田正史、日本産業衛生学会アレルギー免疫毒性研究会．予防・臨床医学理論と実践体系におけるアレルギー・免疫毒性制御２．現代社会を取り巻く環境因子と気管支喘息発症メカニズム．産業衛生学雑誌2024, in press

2.和田裕雄、白濱龍太郎、植田結人、細川まゆ子、津田徹、谷川武．職域における睡眠・休養の問題「長時間労働の医師への健康確保措置に関するマニュアル」作成の科学的背景. 産業衛生学雑誌 2024, 66: 202-206.

3.和田裕雄、植田結人、谷川武．医師の働き方改革における追加的健康確保措置．医学のあゆみ 2023; 287:596-600

4.和田裕雄、今中雄一、磯博康．厚労省科学研究における調査から：VUCA時代に求められる公衆衛生人材．公衆衛生 2023; 87 (9): 881-889.

5.和田裕雄、安田行宏．健康経営と企業パフォーマンスに関する論点整理．証券アナリストジャーナル 2023;61 (7):18-30.

6.和田裕雄、谷川武. 睡眠時無呼吸症候群が社会に与える影響. 耳鼻咽喉科・頭頸部外科2023; 95(4): 299-304.

7.土橋邦生、吉田貴彦、森本泰夫、上田厚、伊藤俊弘、和田裕雄、香山不二雄、佐藤一博、佐藤実、柴田英治、菅沼成文、竹下達也、角田正史、西村泰光、柳澤裕之、李卿、日本産業衛生学会アレルギー免疫毒性研究会．予防・臨床医学理論と実践体系におけるアレルギー・免疫毒性制御　職業アレルギーとイソシアネート喘息．産業衛生学雑誌2023; 65: 1-8.

8.和田裕雄、谷川武. 睡眠時無呼吸症候群 (SAS) の疫学. 呼吸器内科　2022、41.4: 320-325.

9.稲垣暢也、磯博康、今中雄一、永井良三、杉山雄大、亀田義人、平木秀輔、和田裕雄、高野彩佳、飯島由佳、村越和輝.合同シンポジウム臨床医学と社会医学の未来. 日本内科学会雑誌2022; 111(9): 2004-2028.

10.和田裕雄、谷川武．高齢者の睡眠時無呼吸．老年内科2021; 4: 583-588.

11.和田裕雄、谷川武．ひとくちメモ：睡眠呼吸障害と運転のリスク．日本医師会雑誌2020; 149: 272.

12.和田裕雄, 谷川武．睡眠の諸問題　連載を終えるに当たって．公衆衛生2020; 84: 480-484.

13.和田裕雄、木村真奈美、谷川武. OSAとCSAの頻度. 呼吸器ジャーナル 2019; 67: 406-413.

14.和田裕雄、白濱龍太郎、津田徹、谷川武、職域における睡眠呼吸障害研究会．職域における睡眠呼吸障害と健康経営.日本産業衛生学雑誌. 2019; 61: 89-94.

15.和田裕雄、横山和仁．臨床医学の「診療」と社会医学の「実践」の接点．保健の科学 2018; 60: 465-470.

16.和田裕雄、谷川武．検査室外睡眠検査（OCST）の現状と適正使用．睡眠医療 2016; 36: 511-517.

17.和田裕雄、COPDの一次予防．呼吸器内科 2016; 30: 463-472.

18.和田裕雄、谷川武．睡眠呼吸障害の疫学．MB Medical Rehabilitation 2016; 203: 90-97.

19.和田裕雄、谷川武．睡眠障害と交通事故． Progress Med 2016; 36: 511-517.

〈英文原著・総説〉
1. Hamada S, Ueki J, Hirai T, Sano E, Hino K, Ikeda M, Sato S, Oga T, Tsuboi T, Kurosawa H, Wada H, On behalf of the Japanese White Paper on Home Respiratory Care 2024 working group. Current status and regional differences in disaster planning and preparedness for long-term oxygen therapy: The Japanese White Paper on Home Respiratory Care 2024. Respir Investig 2025, in press

2. Takeyama E, Tomooka K, Kunimatsu-Sanuki S, Sato S, Sakiyama N, Wada H, Matsumoto C. Tanigawa T. The association between self-checked visual field impairment and motor vehicle accidents among Japanese taxi drivers. Sci Rep 2025, in press

3. Yaegashi T, Wada H, Ueda Y, Zhu Q, Maruyama K, Kameda Y, Shirahama R, Ikeda A, Nakano H, Tanigawa T. Association between Asthma and Sleep-Disordered Breathing in Elementary School Children in Japan. Sleep Med 2025, in press

4. Zhu Q, Wada H, Ueda Y, Onuki K, Miyakawa M, Sato S, Kameda Y, Matsumoto F, Inoshita A, Nakano H, Tanigawa T. Association between subjective sleepiness and vigilant attention in elementary school students. Sleep Health 2025, in press.

5. Watanabe R, Ikeda A, Charvat H, Sato S, Suzuki Y, Maruyama K, Tomooka K, Wada H, Koyama Y, Tanigawa T. Association between levels of satisfaction with interpersonal relationships and insomnia symptoms among women working in aged-care services in Japan. Environ Health Prev Med. 2025; 30: 47.

6. Furuya R, Wada H, Onuki K, Kitazawa T, Miyakawa M, Zhu Q, Ueda Y, Sato S, Nakano H, Gozal D, Tanigawa T. Association between insufficient aleep and constipation among elementary school children in Japan. Sleep Biol Rhythms. 2025, in press

7. Hamada S, Ueki J, Hirai T, Sano E, Hino K, Ikeda M, Sato S, Oga T, Tsuboi T,　Kurosawa H, Wada H, on behalf of the Japanese White Paper on Home Respiratory Care 2024 working group. Current trends in long-term oxygen therapy and home mechanical ventilation: a summary of the Japanese White Paper on Home Respiratory Care 2024. Respir Investig 2025, in press.

8. Wada H, Basner M, Cordoza M, Dinges D, Tanigawa T. Objective alertness, rather than sleep duration, is associated with burnout and depression: a national survey of Japanese physicians. J Sleep Res 2025; 34(1): e14304.

9. Iwata K, Sato M, Yoshida S, Wada H, Sekimizu K, Okazaki M. Histopathological analysis of filament formation of Nocardia farcinica in a silkworm infection model. Drug Discov Ther 2024; 18(5): 290-295.

10. Petrarca C, Viola D, Resta A, Di Giampaolo L, Wada H. Asbestos-related and non-communicable diseases in formerly exposed workers: relationship with residential asbestos, smoke and business sector. J Community Med Pub Health 2024; 8: 450. doi.org/10.29011/2577-2228.100450.

11. Wada H, Basner M, Cordoza M, Dinges D, Tanigawa T. Objective alertness, rather than sleep duration, is associated with burnout and depression: a national survey of Japanese physicians. J Sleep Res 2024: e14304. doi: 10.1111/jsr.14304.

12. Matsuura Y, Tomooka K, Wada H, Sato S, Endo M, Taneda K, Tanigawa T. The association of long working hours and short sleep duration on mental health among Japanese physicians. Ind Health. 2024 in press. doi:10.2486/indhealth.2023-0174.

13. Zhu Q, Wada H, Ueda Y, Onukia K, Miyakawa M, Sato S, Kameda Y, Matsumoto F, Inoshita A, Nakano H, Tanigawa T. Association between habitual snoring and vigilant attention in elementary school children. Sleep Med. 2024; 118: 9-15.

14. Wada H, Nakano H, Sakurai S, Tangiawa T. Self-reported Sleep Tendency Poorly Predicts the Presence of Obstructive Sleep Apnea in Commercial Truck Drivers. Sleep Med. 2024; 115: 109-113.

15. Koike S, Wada H, Ohde S, Ide H, Taneda K, Tanigawa T. Working hours of full-time hospital physicians in Japan: a cross-sectional nationwide survey. BMC Public Health. 2024; 24(1): 164. doi: 10.1186/ s12889-023-17531-5.

16. Kitazawa T, Wada H, Onuki K, Furuya R, Miyakawa M, Zhu Q, Ueda Y, Sato S, Kameda Y, Nakano H, Gzoazl D, Tanigawa T. Snoring, obstructive sleep apnea and upper respiratory tract infection in elementary school children in Japan. Sleep Breath. 2023; 10.1007/s11325-023-02932-y

17. Kimura T, Kawano H, Muto S, Muramoto N, Takano T, Lu Y, Eguchi H, Wada H, Okazaki Y, Ide H, Horie S. PKD1 mutation is a biomarker for autosomal dominant polycystic kidney disease. Biomolecules 2023; 13(7): 1020. doi: 10.3390/biom13071020.

18. Nishizaki Y, Kuroki H, Ishii S, Ohtsu S, Watanabe C, Nishizawa H, Nagao M, Nojima M, Watanabe R, Sato D, Sato K, Kawata Y, Wada H, Toyoda G, Ohbayashi K.. Determining Optimal Intervals for In-Person Visits During Video-Based Telemedicine Among Patients With Hypertension: Cluster Randomized Controlled Trial. JMIR Cardio. 2023; 7: e45230.

19. Zhu Q, Wada H, Onuki K, Kitazawa T, Furuya R, Miyakawa M, Sato S, Yonemoto N, Ueda Y, Nakano H, Gozal D, Tanigawa T. Validity and reliability of the Japanese version of the severity hierarchy score for pediatric obstructive sleep apnea screening. Sleep Med 2023; 101: 357-364.

20. Matsuo R, Tanigawa T, Oshima A, Tomooka K, Ikeda A, Wada H, Maruyama K, Saito I. Decreased psychomotor vigilance is a risk factor for motor vehicle crashes irrespective of subjective daytime sleepiness: the Toon Health Study. J Clin Sleep Med. 2023; 19(2): 319-325.

21. Wada H, Yasuda Y. Value Effect of Health and Productivity Management: An Event Study of the HPM Award in Japan. J Occup Environ Med. 2022; 64(6): 465-469.

22. Wada H, Nakamura M, Inoue SI, Kudo A, Hanawa T, Iwakura Y, Kobayashi F, Kamma H, Kamiya S, Ito K, Barnes PJ, Takizawa H. Dual Interleukin-17A/F Deficiency Protects against Acute and Chronic Response to Cigarette Smoke Exposure in Mice. Sci Rep 2021, 11: 11508. doi: 10.1038/s41598-021-90853-9.

23. Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H. Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort, The JACC Study. Sci Rep 2021; 11: 1531. doi: 10.1038/s41598-020-79860-4.

24. Wada H, Kondo K, Tanigawa T. Snoring is a pathogenic symptom: A need for its objective assessment. Geriatr Gerontol Int. 2020; 20(6): 648-649.

25. Wada H, Furuya S, Maruyama K, Ikeda A, Kondo K, Tanigawa T, on behalf of JAGES group. The prevalence and clinical impact of snoring in older community-dwelling adults. Geriatr Gerontol Int 2019; 19: 1165-1171.

26. Wada H, Kimura M, Shiarahama R, Ikeda A, Gozal D, Tanigawa T. Pectus excavatum is associated with sleep-related breathing disorders in children. Eur Respir J 2019; 54: pii: 1900524.

27. Wada H, Nagata K, Shirahama R, Tajima T, Kimura M, Ikeda A, Maruayma K, Tamura M, Suzuki K, Tanigawa T. The impact of sleep disordered breathing on performance in Judo players. BMJ Open Sport Exerc Med 2019; 5: e000418. (Official Journal of British Association of Sport and Exercise Medicine.)

28. Wada H, Fukumoto S, Tamamura K, Muto G, Ueki J, Tanigawa T. Toward the harmonization of work with treatment and prevention for patients with chronic respiratory failure. Ind Health 2019; 57: 84-89.

29. Wada H, Kimura M, Shirahama R, Tajima T, Maruyama K, Endo M, Ikeda A, Tanigawa T. Harmonizing work with the treatment and prevention of sleep disordered breathing in commercial motor vehicle drivers: implications for Health and Productivity Management. Ind Health 2019; 57: 3-9.

30. Wada H, Kimura M, Tajima T, Shirahama R, Suzuki Y, Suzuki Y, Hayashi T, Maruyama K, Endo M, Sakamoto N, Ikeda A, Gozal D, Tanigawa T. Nocturnal enuresis and sleep disordered breathing in primary school children: potential implications. Pediatir Pulm 2018, 53: 1541-1548.

31. Wada H, Shirahama R, Kimura M, Tajima T, Inoshita A, Tanigawa T. Sleep Disordered Breathing in Children. Juntendo Med J 2017; 63: 443-448.

32. Wada H, Ikeda A, Kales SA, Tanigawa T. Screening for sleep disordered breathing (SDB) in truck drivers in the US. Juntendo Med J 2015; 61: 350-351.

33. Wada H, Inui T, Nakamoto K, Sada M, Nakamura M, Takizawa H. A pivotal Role of Nrf2 in Airway Inflammatory Responses Inducedby Diesel Exhaust in Asthma: Mechanisms and Their Application to Clinical Interventions. 2015 in press.

34. Wada H, Akiyama Y, Takeda H, Nakamura M, Takizawa H. Social isolation in patients with chronic respiratory failure (CRF), undergoing long-term oxygen therapy (LTOT). J Am Geriatr Soc 2014; 62: 1807-1808.

35. Wada H, Hagiwara S, Yamamoto Y and Takizawa H. Links between lung dysfunction and glucose metabolism dysregulation: does lung dysfunction represent a systemic disorder? Intern Med 2014; 53; 2413-2414.

36. Kobayashi Y, Wada H, Rossios C, Takagi D, Charron C, Barnes PJ and Ito K. “A novel macrolide/fluoroketolide, splithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition",　Br J Pharmacol 2013; 169: 1024-1034.

37. Koybayashi Y, Wada H, Rossios C, Takagi D, Higaki M, Mikura S, Goto H and Barnes PJ. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-B inhibition. J Pharmacol Exp Ther 2013; 345: 76-85. [doi: 10.1124/jpet.112.200733.]

38. Yasutake T, Wada H, Higaki M, Nakamura M, Honda K, Watanabe M, Ishii H, Kamiya S, Takizawa H, and Goto H. Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549. F1000Research 2013, 2: 78 [doi: 10.12688/f1000research. 2-78.v1].

39. Wada H and Takizawa H. Future Treatment for COPD: targeting oxidative stress and its related signal. Recent Pat Inflamm Allergy Drug Discov 2013; 7: 1-11.[ doi: 10.2174/1872213X11307010001]

40. Ohnishi H, Yonetani S, Matsushima S, Wada H, Takeshita K, Kuramochi D, De Souza PC, Campos CED, Da Costa BP, Ramos JP, Mikura S, Narisawa E, Fujita A, Funayama Y, Kobashi Y, Sakakibara Y, Ishiyama Y, Takakura S, Goto H, Watanabe T. Mycobacterium kyorinense Infection: Clinical Features and Antimicrobial Susceptibility. Emerg Infect Dis 2013; 19: 508-510.[ doi: 10.3201/eid1903.120591]

41. 1Hiraoka S*, Wada H*, MoritaK, Honda K, Koyanagi M, Y okoyama K, Fukuchi Y, Nitatori T, Goto H. Pulmonary volumetric analyses based on three-dimensional computed tomography (3D-CT), compared with pulmonary function test. Jpn J Diagn Imaging 2012; 30: 145-155. (*equal contribution to this publication.)

42. Wada H, Hagiwara S, Saitoh E, Ieki R, Yamamoto Y, Adcock IM and Goto H. Up-regulation of blood arachidonate (20:4) levels in patients with chronic obstructive pulmonary disease (COPD). BioMarkers 2012; 17: 520-523. [doi: 10.3109/1354750X.2012.692393.]

43. Watanabe A, Goto H, Soma K, Kikuchi T, Gomi K, Miki H, Maemondo M, Ikeda H, Kuroki J, Wada H, Yokoyama T, Izumi S, Mitsutake K and Ueda Y “Usefulness of linezolid in the treatment of hospital-acquired pneumonia caused by MRSA: a prospective observational study” J Infect Chemother 2012; 18: 160-168.

44. Saraya T, Nakata K, Nakagaki K, Motoi N, Iihara K, Fujioka Y, Oka T, Kurai D, Wada H, Ishii H, Taguchi H, Kamiya S and Goto H. “Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.” Results in Immunology 2011; 1: 76-87.

45. Mikura S, Wada H, Okazaki M, Nakamura M, Honda K, Yasutake T, Higaki M, Ishii T, Watanabe T, Tsunoda T and Goto H. “Risk factors for bacteraemia attributable to Pseudomonas aeruginosa resistant to imipenem, levofloxacin, or gentamicin.” J Hosp Infect 2011; 79: 267-268.

46. Takata S, Wada H, Tamura M, Koide T, Higaki M, Mikura S, Yasutake T, Hirao S, Nakamura M, Honda K, Nagatomo T, Tanaka Y, Watanabe M, Yokoyama T, Saraya T, Kurai D, Ishii H and Goto H. "Kinetics of c-reactive protein (CRP) and serum amyloid A protein (SAA) in patients with community acquired pneumonia (CAP), as presented with biologic half-life times.” BioMarkers 2011; 16: 530-535.

47. Ohshima N, Matsui H, Matsui Y, Kawashima M, Shimada M, Higaki N, Shoji S, Wada H, Fujita A, Watanabe H, Yamaguchi N, Matsuoka R, Oki K, Takahashi H, Suzuki M, Yamazaki H , Yoshizawa M and Goto H “Addition of leukotriene receptor antagonists to inhaled corticosteroids improved QOL of patients with bronchial asthma surveyed in suburban Tokyo, Japan.” Allergol Int 2011; 60: 473-481.

48. Hirao S, Wada H, Nakagaki K, Saraya T, Kurai D, Mikura S, Yasutake T, Higaki M, Yokoyama T, Ishii H, Nakata K, Akashi T, Kamiya S and Goto H. “Inflammation provoked by Mycoplasma pneumoniae extract: implications for combination treatment with clarithromycin and dexamethasone” FEMS Immunology & Medical Microbiology 2011; 62: 182-189.

49. Mikura S, Wada H, Higaki M, Yasutake T, Ishii H, Kamiya S and Goto H “Erythromycin prevents the pulmonary inflammation induced by exposure to cigarette smoke” Transl Res 2011; 158: 30-37.

50. Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Goto H, Bemis JE, Elliott P, Barnes PJ and Ito K “A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9” FASEB J 2009; 23: 2810-2819

51. Wada H, Yamamoto M, Okazaki M, Watanabe T and Goto H. Isolation of Mycobacterium kyorinense in a patient with respiratory failure. Ann Intern Med 2009; 150: 568-570

52. Wada H, Hagiwara S, Goto H and Yamamoto Y, The redox status of coenzyme Q10 associated to the chronological age. J Am Geriatrics Soc 2007; 55: 1141-1142.

53. Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Iguchi M, Yuasa K, Kodaka T, Koishi T, Yamamoto Y and Goto H. Increased oxidative stress in patients with chronic obstructive pulmonary disesase (COPD) as measured by redox status of plasma coenzyme Q10. Pathophysiology 2006; 13: 29-33.

54. Wada H, Hagiwara S, Saitoh E, Ieki R, Okamura T, Ota T, Kodaka T, Yamamoto Y and Goto H. Reduction in Plasma Free Fatty Acid in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2005; 171: 1465.

55. Wada H, Kagoshima M, Ito K, Barnes PJ and Adcock IM. 5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene. Biochem Biophys Res Comm 2005; 331: 93-99.

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和田 裕雄（ワダ ヒロオ）

和田裕雄（ワダヒロオ）