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佐々木啓（ササキヒラク）

研究テーマ	日和見病原体の病原性と免疫応答、新規ワクチンと疫学に関する研究
研究業績（論文）	・Zhang M, Sasaki H, Yang T, Chen J, Li R, Yi C, Li J, He M, Yi SQ. 2023. Fecal microbiota transplantation from Suncus murinus, an obesity-resistant animal, to C57BL/6NCrSIc mice, and the antibiotic effects in the approach. Frontiers in Microbiology 14:1138983. ・Sasaki H, Ueshiba H, Yanagisawa N, Itoh Y, Ishikawa H, Shigenaga A, Benga L, Ike F. 2022. Genomic and pathogenic characterization of RTX toxin producing Rodentibacter sp. that is closely related to Rodentibacter haemolyticus Infection, Genetics and Evolution 102:105314. ・Ishikawa H, Kunoa Y, Kohda C, Sasaki H, Nagashima R, Iyoda M. 2022. Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 prevent influenza virus infection and attenuate secondary bacterial infection risk. Letters in Applied Microbiology 74(5):632-639. doi: 10.1111/lam.13649. ・Sasaki H, Fukunaga T, Asano A, Tsumita M, Suzuki Y, Shibata N. 2021. Persistence of anti-rubella immunoglobulin G antibody titres in young adults involved in a short-term periodic immunisation in Japan. Japanese Journal of Infectious Diseases 74(5):473-476. ・Sasaki H, Fukunaga T, Asano A, Yamanaka K, Oikawa K, Shibata N. 2021. Seroprevalence of anti-mumps virus IgG antibody titer and voluntary mumps vaccination coverage in young adults in Japan. Human Vaccines and Immunotherapeutics 17(9):3153-3155. ・Sasaki H, Ishikawa H, Itoh T, Arano M, Hirata K, Ueshiba H. 2021. Penicillin-binding proteins and associated protein mutations confer oxacillin/cefoxitin tolerance in borderline oxacillin-resistant Staphylococcus aureus. Microbial Drug Resistance 27(5):590-595. ・Zhang MS, Dai YD, Terayama H, Sasaki H, Ren K, Wang ZD, Chen JF, Yamamoto Y, Yi SQ. 2020. High fat diet load study in a natural obesity-resistant animal model, Suncus murinus. Journal of Veterinary Science and Research 2:19-29. ・Ishikawa H, Ino S, Yamochi T, Sasaki H, Kobayashi T, Kohda C, Takimoto M, Tanaka K. 2020. NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway. Biochemistry and Biophysics Reports 21:100722. ・Sasaki H, Fukunaga T, Asano A, Suzuki Y, Nakanishi Y, Kondo J, Ishikawa H, Shibata N. 2019. A survey of vaccine-induced measles IgG antibody titer to verify temporal changes in response to measles vaccination in young adults. Vaccines (Basel) 7: E118. ・Nguyen VH, Kikuchi H, Sasaki H, Iizumi K, Kubohara Y, Oshima Y. 2017. Production of novel bispyrone metabolites in the cellular slime mold Dictyostelium giganteum induced by zinc(II) ion. Tetrahedron 73(5): 583–588. ・Terayama H, Hirai S, Naito M, Qu N, Katagiri C, Nagahori K, Hayashi S, Sasaki H, Moriya S, Hiramoto M, Miyazawa K, Hatayama N, Li ZL, Sakabe K, Matsushita M, Itoh M. 2016. Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone. Scientific Reports 6:35599 DOI: 10.1038/srep35599 ・Ishikawa H, Fukui T, Ino S, Sasaki H, Awano N, Kohda C, Tanaka K. 2016. Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung. Virology 499:23-29. ・Sasaki H, Ishikawa H, Terayama H, Asano R, Kawamoto E, Ishibashi H, Boot R. 2016. Identification of a virulence determinant that is conserved in the Jawetz and Heyl biotypes in [Pasteurella] pneumotropica. Pathogens and Disease 74(6):ftw066 ・Ishikawa H, Ino S, Sasaki H, Fukui T, Kohda C, Tanaka K. 2016. The protective effects of intranasal administration of IL-12 given before influenza virus infection and the negative effects of IL-12 treatment given after viral infection. Journal of Medical Virology 88:1487–1496. ・Sasaki H, Awais R, Takahashi J, Tanji Y, Tada C, Nakai Y. 2015. Effect of grazing on fecal shedding of pathogenic Escherichia coli in beef cattle. Journal of Integrated Field Science 12: 39-42. ・Sasaki H, Ishikawa H, Asano R, Ueshiba H, Matsumoto T, Boot R, Kawamoto E. 2014. Draft genome sequence of the rodent opportunistic pathogen Pasteurella pneumotropica ATCC 35149T. Genome Announcements 2(4):e00771-14 ・Sasaki H, Ishikawa H, Kojima K, Itoh M, Matsumoto T, Kawamoto E. 2013. Intranasal immunization with a non-adjuvanted adhesive protein descended from Pasteurella pneumotropica and its preventive efficacy against opportunistic infection in mice. Vaccine 31:5729-5735. ・Ishikawa H, Awano N, Fukui T, Sasaki H, Kyuwa S. 2013. The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication. Biochemical and Biophysical Research Communication 434(4):791-6. ・Ishikawa H, Sasaki H, Fukui T, Fujita K, Kutsukake E, Matsumoto T. 2012. NK cells activated by the induction of asthma play an important role in protecting mice from influenza virus infection. J Clin Immunol 32:256–267. ・Ishikawa H, Tanaka K, Kutsukake E, Fukui T, Sasaki H, Hata A, Noda S, Matsumoto T. 2010. IFN-γ production downstream of NKT cell activation in mice infected with influenza virus enhances the cytolytic activities of both NK cells and viral antigen-specific CD8+ T cells. Virology 407:325-332 ・Sasaki H, Kawamoto E, Tanaka Y, Sawada T, Kunita S, Yagami K. 2009. Identification and characterization of hemolysin-like proteins similar to RTX toxin in Pasteurella pneumotropica. J Bacteriol 191:3698-3705. ・Sasaki H, Kawamoto E, Tanaka Y, Sawada T, Kunita S, Yagami K. 2009. Comparative analysis of Pasteurella pneumotropica isolates from laboratory mice and rats. Antonie van Leeuwenhoek 95:311-317. ・Sthitmatee N, Numee S, Kawamoto E, Sasaki H, Yamashita K, Takahashi N, Kataoka Y, Sawada T. 2008. Protection of chickens from fowl cholera by vaccination with recombinant adhesive protein of Pasteurella multocida. Vaccine 26:2398-2407. ・Wakase S, Sasaki H, Ito K, Otawa K, Kitazume O, Nonaka J, Satoh M, Sasaki T, Nakai Y. 2008. Investigation of the microbial community in a microbiological additive used in a manure composting process. Bioresource Technol 99:2687-2693. ・Sasaki H, Nonaka J, Sasaki T, Nakai Y. 2007. Ammonia removal from livestock wastewater by ammonia-assimilating microorganisms immobilized in polyvinyl alcohol. Journal of Industrial Microbiology and Biotechnology 34:105–110. ・Sasaki H, Kawamoto E, Okiyama E, Ueshiba H, Amao H, Sawada T. 2006. Molecular typing of Pasteurella pneumotropica by amplified ribosomal DNA analysis and pulsed-field gel electrophoresis. Microbiology and Immunology, 50:265-272. ・Sasaki H, Yano H, Sasaki T, Nakai Y. 2005. A survey of ammonia-assimilating micro-organisms in cattle manure composting. Journal of Applied Microbiology, 99: 1356-1363.

研究テーマ

日和見病原体の病原性と免疫応答、新規ワクチンと疫学に関する研究

研究業績（論文）

・Zhang M, Sasaki H, Yang T, Chen J, Li R, Yi C, Li J, He M, Yi SQ. 2023. Fecal microbiota transplantation from Suncus murinus, an obesity-resistant animal, to C57BL/6NCrSIc mice, and the antibiotic effects in the approach. Frontiers in Microbiology 14:1138983.
・Sasaki H, Ueshiba H, Yanagisawa N, Itoh Y, Ishikawa H, Shigenaga A, Benga L, Ike F. 2022. Genomic and pathogenic characterization of RTX toxin producing Rodentibacter sp. that is closely related to Rodentibacter haemolyticus Infection, Genetics and Evolution 102:105314.
・Ishikawa H, Kunoa Y, Kohda C, Sasaki H, Nagashima R, Iyoda M. 2022. Exopolysaccharides from Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 prevent influenza virus infection and attenuate secondary bacterial infection risk. Letters in Applied Microbiology 74(5):632-639. doi: 10.1111/lam.13649.
・Sasaki H, Fukunaga T, Asano A, Tsumita M, Suzuki Y, Shibata N. 2021. Persistence of anti-rubella immunoglobulin G antibody titres in young adults involved in a short-term periodic immunisation in Japan. Japanese Journal of Infectious Diseases 74(5):473-476.
・Sasaki H, Fukunaga T, Asano A, Yamanaka K, Oikawa K, Shibata N. 2021. Seroprevalence of anti-mumps virus IgG antibody titer and voluntary mumps vaccination coverage in young adults in Japan. Human Vaccines and Immunotherapeutics 17(9):3153-3155.
・Sasaki H, Ishikawa H, Itoh T, Arano M, Hirata K, Ueshiba H. 2021. Penicillin-binding proteins and associated protein mutations confer oxacillin/cefoxitin tolerance in borderline oxacillin-resistant Staphylococcus aureus. Microbial Drug Resistance 27(5):590-595.
・Zhang MS, Dai YD, Terayama H, Sasaki H, Ren K, Wang ZD, Chen JF, Yamamoto Y, Yi SQ. 2020. High fat diet load study in a natural obesity-resistant animal model, Suncus murinus. Journal of Veterinary Science and Research 2:19-29.
・Ishikawa H, Ino S, Yamochi T, Sasaki H, Kobayashi T, Kohda C, Takimoto M, Tanaka K. 2020. NKT cells are responsible for the clearance of murine norovirus through the virus-specific secretory IgA pathway. Biochemistry and Biophysics Reports 21:100722.
・Sasaki H, Fukunaga T, Asano A, Suzuki Y, Nakanishi Y, Kondo J, Ishikawa H, Shibata N. 2019. A survey of vaccine-induced measles IgG antibody titer to verify temporal changes in response to measles vaccination in young adults. Vaccines (Basel) 7: E118.
・Nguyen VH, Kikuchi H, Sasaki H, Iizumi K, Kubohara Y, Oshima Y. 2017. Production of novel bispyrone metabolites in the cellular slime mold Dictyostelium giganteum induced by zinc(II) ion. Tetrahedron 73(5): 583–588.
・Terayama H, Hirai S, Naito M, Qu N, Katagiri C, Nagahori K, Hayashi S, Sasaki H, Moriya S, Hiramoto M, Miyazawa K, Hatayama N, Li ZL, Sakabe K, Matsushita M, Itoh M. 2016. Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone. Scientific Reports 6:35599 DOI: 10.1038/srep35599
・Ishikawa H, Fukui T, Ino S, Sasaki H, Awano N, Kohda C, Tanaka K. 2016. Influenza virus infection causes neutrophil dysfunction through reduced G-CSF production and an increased risk of secondary bacteria infection in the lung. Virology 499:23-29.
・Sasaki H, Ishikawa H, Terayama H, Asano R, Kawamoto E, Ishibashi H, Boot R. 2016. Identification of a virulence determinant that is conserved in the Jawetz and Heyl biotypes in [Pasteurella] pneumotropica. Pathogens and Disease 74(6):ftw066
・Ishikawa H, Ino S, Sasaki H, Fukui T, Kohda C, Tanaka K. 2016. The protective effects of intranasal administration of IL-12 given before influenza virus infection and the negative effects of IL-12 treatment given after viral infection. Journal of Medical Virology 88:1487–1496.
・Sasaki H, Awais R, Takahashi J, Tanji Y, Tada C, Nakai Y. 2015. Effect of grazing on fecal shedding of pathogenic Escherichia coli in beef cattle. Journal of Integrated Field Science 12: 39-42.
・Sasaki H, Ishikawa H, Asano R, Ueshiba H, Matsumoto T, Boot R, Kawamoto E. 2014. Draft genome sequence of the rodent opportunistic pathogen Pasteurella pneumotropica ATCC 35149T. Genome Announcements 2(4):e00771-14
・Sasaki H, Ishikawa H, Kojima K, Itoh M, Matsumoto T, Kawamoto E. 2013. Intranasal immunization with a non-adjuvanted adhesive protein descended from Pasteurella pneumotropica and its preventive efficacy against opportunistic infection in mice. Vaccine 31:5729-5735.
・Ishikawa H, Awano N, Fukui T, Sasaki H, Kyuwa S. 2013. The protective effects of lactoferrin against murine norovirus infection through inhibition of both viral attachment and replication. Biochemical and Biophysical Research Communication 434(4):791-6.
・Ishikawa H, Sasaki H, Fukui T, Fujita K, Kutsukake E, Matsumoto T. 2012. NK cells activated by the induction of asthma play an important role in protecting mice from influenza virus infection. J Clin Immunol 32:256–267.
・Ishikawa H, Tanaka K, Kutsukake E, Fukui T, Sasaki H, Hata A, Noda S, Matsumoto T. 2010. IFN-γ production downstream of NKT cell activation in mice infected with influenza virus enhances the cytolytic activities of both NK cells and viral antigen-specific CD8+ T cells. Virology 407:325-332
・Sasaki H, Kawamoto E, Tanaka Y, Sawada T, Kunita S, Yagami K. 2009. Identification and characterization of hemolysin-like proteins similar to RTX toxin in Pasteurella pneumotropica. J Bacteriol 191:3698-3705.
・Sasaki H, Kawamoto E, Tanaka Y, Sawada T, Kunita S, Yagami K. 2009. Comparative analysis of Pasteurella pneumotropica isolates from laboratory mice and rats. Antonie van Leeuwenhoek 95:311-317.
・Sthitmatee N, Numee S, Kawamoto E, Sasaki H, Yamashita K, Takahashi N, Kataoka Y, Sawada T. 2008. Protection of chickens from fowl cholera by vaccination with recombinant adhesive protein of Pasteurella multocida. Vaccine 26:2398-2407.
・Wakase S, Sasaki H, Ito K, Otawa K, Kitazume O, Nonaka J, Satoh M, Sasaki T, Nakai Y. 2008. Investigation of the microbial community in a microbiological additive used in a manure composting process. Bioresource Technol 99:2687-2693.
・Sasaki H, Nonaka J, Sasaki T, Nakai Y. 2007. Ammonia removal from livestock wastewater by ammonia-assimilating microorganisms immobilized in polyvinyl alcohol. Journal of Industrial Microbiology and Biotechnology 34:105–110.
・Sasaki H, Kawamoto E, Okiyama E, Ueshiba H, Amao H, Sawada T. 2006. Molecular typing of Pasteurella pneumotropica by amplified ribosomal DNA analysis and pulsed-field gel electrophoresis. Microbiology and Immunology, 50:265-272.
・Sasaki H, Yano H, Sasaki T, Nakai Y. 2005. A survey of ammonia-assimilating micro-organisms in cattle manure composting. Journal of Applied Microbiology, 99: 1356-1363.

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【学校法人順天堂】研究者情報データベース

研究業績詳細

佐々木 啓（ササキ ヒラク）

佐々木啓（ササキヒラク）