HOME ＞ 研究業績詳細
研究業績詳細
大津 洋（オオツ ヒロシ）
| 研究テーマ | 生物統計学,臨床試験方法論,データサイエンス,レギュラトリーサイエンス |
|---|---|
| 研究業績（論文） | 1. 原著論文 1-1 英文原著 2025年 1. Ohtsu, H., Fujioka, I., Goto, M., Takai, C., Yonemoto, N., Sase, K., & Murashima, A. (2025). Five-Year Delivery Rate and Time to Delivery Among Women With and Without Rheumatoid Arthritis: A Real-World Analysis Using a Nationwide Claims Database in Japan. International Journal of Rheumatic Diseases. 2. Miyazato, K., Ohtsu, H., Shimomura, A., Yonemoto, N., Shimizu, C., Sase, K., & Ueda, S. (2025). Impact of adjuvant trastuzumab therapy and its discontinuation on cardiac function and mortality in patients with early-stage breast cancer: An analysis based on the Japanese Receipt Claim Database. Breast (Edinburgh, Scotland). 2024年 1. Homma, Y., Yamasaki, T., Tashiro, K., Okada, Y., Shirogane, Y., Watari, T., Hayashi, K., Baba, T., Nagata, K., Yanagisawa, N., Ohtsu, H., Fujiwara, N., Ando, J., Yamaji, K., Tamura, N., & Ishijima, M. (2024). Autologous concentrated bone marrow injection for precollapse osteonecrosis of the femoral head concurrent with contralateral total hip arthroplasty: protocol for a clinical trial. BMJ Open. 2. Bouchi, R., Izumi, K., Ishizuka, N., Uemura, Y., Ohtsu, H., Miyo, K., Tanaka, S., Satoh-Asahara, N., Hara, K., Odawara, M., Kusunoki, Y., Koyama, H., Onoue, T., Arima, H., Tsushita, K., Watada, H., Kadowaki, T., & Ueki, K. (2024). Internet of things-based approach for glycemic control in people with type 2 diabetes: A randomized controlled trial. Journal of Diabetes Investigation. 3. Saita, K., Sumitani, M., Koyama, Y., Sugita, S., Matsubayashi, Y., Ogata, T., Ohtsu, H., & Chikuda, H. (2024). Neuropathic pain development and maintenance and its association with motor recovery after cervical spinal cord injury. The Journal of Spinal Cord Medicine. 2023年 1. Uemura, Y., Ozaki, R., Shinozaki, T., Ohtsu, H., Shimizu, Y., Izumi, K., Saito, S., Matsunaga, N., & Ohmagari, N. (2023). Comparative effectiveness of tocilizumab vs standard care in patients with severe COVID-19-related pneumonia: a retrospective cohort study utilizing registry data as a synthetic control. BMC Infectious Diseases. 2. Terada, M., Saito, S., Kutsuna, S., Kinoshita-Iwamoto, N., Togano, T., Hangaishi, A., Shiratori, K., Takamatsu, Y., Maeda, K., Ishizaka, Y., Ohtsu, H., Satake, M., Mitsuya, H., & Ohmagari, N. (2023). Efficacy and Safety of Treatment with Plasma from COVID-19-Recovered Individuals. Life (Basel, Switzerland). 3. Iwase, T., Saji, S., Iijima, K., Higaki, K., Ohtani, S., Sato, Y., Hozumi, Y., Hasegawa, Y., Yanagita, Y., Takei, H., Tanaka, M., Masuoka, H., Tanabe, M., Egawa, C., Komoike, Y., Nakamura, T., Ohtsu, H., & Mukai, H. (2023). Postoperative Adjuvant Anastrozole for 10 or 5 Years in Patients With Hormone Receptor–Positive Breast Cancer: AERAS, a Randomized Multicenter Open-Label Phase III Trial. Journal of Clinical Oncology. 4. Egawa, M., Kanda, E., Ohtsu, H., Nakamura, T., & Yoshida, M. (2023). Hypertensive Disorders of Pregnancy are Associated with Cardiovascular Disease in Middle- and Older-Aged Japanese Women. Journal of Atherosclerosis and Thrombosis. 5. Homma, Y., Zhuang, X., Ohtsu, H., Ishii, S., Shirogane, Y., Hayashi, K., Watari, T., Baba, T., & Ishijima, M. (2023). Highly accurate acoustical prediction using support vector machine algorithm for post-operative subsidence after cementless total hip arthroplasty. International Orthopaedics. 2022年 1. Saito, S., Thao, P. T. N., Ishikane, M., Xuan, P. T., Kutsuna, S., Dai, H. Q., Ohtsu, H., Kimura, T., Kiyohara, H., Shimada, Y., Maruoka, Y., Thuy, P. T. P., Phu, T. T., Phuong, H. K., Tra, T. T., Duy, N. L. M., Ohara, H., Kurosu, H., Son, N. T., & Ohmagari, N. (2022). Physical oral care prevents ventilator-associated pneumonia in Vietnam: A prospective interventional study. Journal of Infection and Chemotherapy. 2. Ohtsu, H., Shimomura, A., Miyazaki, S., Yonemoto, N., Ueda, S., Shimizu, C., & Sase, K. (2022). Cardiotoxicity of adjuvant chemotherapy with trastuzumab: a Japanese claim-based data analysis. Open Heart. 3. Todo, T., Ino, Y., Ohtsu, H., Shibahara, J., & Tanaka, M. (2022). A phase I/II study of triple-mutated oncolytic herpes virus G47∆ in patients with progressive glioblastoma. Nature Communications. 4. Todo, T., Ito, H., Ino, Y., Ohtsu, H., Ota, Y., Shibahara, J., & Tanaka, M. (2022). Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial. Nature Medicine. 5. Matsushita, Y., Yokoyama, T., Hayakawa, K., Matsunaga, N., Ohtsu, H., Saito, S., Terada, M., Suzuki, S., Morioka, S., Kutsuna, S., Tsuzuki, S., Hara, H., Kimura, A., & Ohmagari, N. (2022). We should pay more attention to sex differences to predict the risk of severe COVID-19: men have the same risk of worse prognosis as women more than 10 years older. Journal of Epidemiology. 6. Kimura, Y., Ohtsu, H., Yonemoto, N., Azuma, N., & Sase, K. (2022). Endovascular versus open repair in patients with abdominal aortic aneurysm: a claims-based data analysis in Japan. BMJ Surgery, Interventions, & Health Technologies. 7. Matsunaga, N., Hayakawa, K., Asai, Y., Tsuzuki, S., Terada, M., Suzuki, S., Ohtsu, H., Kitajima, K., Toyoda, A., Suzuki, K., Suzuki, M., Saito, S., Uemura, Y., Shibata, T., Kondo, M., Nakamura-Uchiyama, F., Yokota, K., Saito, F., Izumi, K., Sugiura, W., & Ohmagari, N. (2022). Clinical characteristics of the first three waves of hospitalised patients with COVID-19 in Japan prior to the widespread use of vaccination: a nationwide observational study. The Lancet Regional Health - Western Pacific. 8. Fujioka, I., Ohtsu, H., Yonemoto, N., Sase, K., & Murashima, A. (2022). Association between prenatal exposure to antidepressants and neonatal morbidity: An analysis of real-world data from a nationwide claims database in Japan. Journal of Affective Disorders. 9. Egawa, M., Kanda, E., Ohtsu, H., Nakamura, T., & Yoshida, M. (2022). Number of Children and Risk of Cardiovascular Disease in Japanese Women: Findings from the Tohoku Medical Megabank. Journal of Atherosclerosis and Thrombosis. 10. Yoshihara, F., Ohtsu, H., Nakai, M., Tsuzuki, S., Hayakawa, K., Terada, M., Matsunaga, N., Yasuda, S., Ogawa, H., & Ohmagari, N. (2022). Renin-angiotensin system blocker and the COVID-19 aggravation in patients with hypertension, diabetes, renal failure, Cerebro-cardiovascular disease, or pulmonary disease: Report by the COVID-19 Registry Japan. Journal of Cardiology. 11. Chujo, D., Kurokawa, T., Kawabe, A., Takahashi, N., Inagaki, F., Shinohara, K., Hagiwara, S., Edamoto, Y., Ohmagari, N., Hinoshita, F., Tajima, T., Kajio, H., Ohtsu, H., Takemura, N., Matsumoto, S., & Shimoda, M. (2022). Allogeneic islet transplantation with monitoring of islet-specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report. Journal of Diabetes Investigation. 12. Suzuki, M., Hayakawa, K., Asai, Y., Matsunaga, N., Terada, M., Ohtsu, H., Toyoda, A., Takasaki, J., Hojo, M., Yanagawa, Y., Saito, S., Yamamoto, K., Ide, S., Akiyama, Y., Suzuki, T., Moriya, A., Mezaki, K., & Ohmagari, N. (2022). Evaluation of the detection of other pathogens in hospitalized patients with COVID-19 at a tertiary hospital in Japan. Japanese Journal of Infectious Diseases. 13. Hiroi, Y., Ohtsu, H., Uemura, Y., Hayakawa, K., Asai, Y., Kutsuna, S., Terada, M., Sugiura, W., & Ohmagari, N. (2022). Cardiovascular Complications of Hospitalized Patients With Coronavirus Disease 2019 in a Japanese Registry in 2020. Circulation Journal. 14. Nomoto, H., Suzuki, S., Asai, Y., Hayakawa, K., Gatanaga, H., Terada, M., Suzuki, K., Ohtsu, H., Toyoda, A., & Ohmagari, N. (2022). Clinical characteristics and prognosis of immunosuppressed inpatients with COVID-19 in Japan. Journal of Infection and Chemotherapy. 15. Asai, Y., Nomoto, H., Hayakawa, K., Matsunaga, N., Tsuzuki, S., Terada, M., Ohtsu, H., Kitajima, K., Suzuki, K., Suzuki, T., Nakamura, K., Morioka, S., Saito, S., Saito, F., & Ohmagari, N. (2022). Comorbidities as Risk Factors for Severe Disease in Hospitalized Elderly COVID-19 Patients by Different Age-Groups in Japan. Gerontology. 16. Tsubata, Y., Hotta, T., Hamai, K., Furuya, N., Yokoyama, T., Saito, R., Nakamura, A., Masuda, T., Hamaguchi, M., Kuyama, S., Honda, R., Senoo, T., Nakanishi, M., Yamasaki, M., Ishikawa, N., Fujitaka, K., Kubota, T., Ohtsu, H., Kobayashi, K., & Isobe, T. (2022). Incidence of venous thromboembolism in advanced lung cancer and efficacy and safety of direct oral anticoagulants: a multicenter, prospective, observational study (Rising-VTE/NEJ037 study). Therapeutic Advances in Medical Oncology. 17. Chujo, D., Imagawa, A., Yasuda, K., Abiru, N., Awata, T., Fukui, T., Ikegami, H., Kawasaki, E., Katsuki, T., Kobayashi, T., Kozawa, J., Nagasawa, K., Ohtsu, H., Oikawa, Y., Osawa, H., Shimada, A., Shimoda, M., Takahashi, K., Tsuchiya, K., Tsujimoto, T., Yasuda, H., Hanafusa, T., & Kajio, H. (2022). Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design. Diabetology International. 2021年 1. Matsushita, Y., Yokoyama, T., Hayakawa, K., Matsunaga, N., Ohtsu, H., Saito, S., Terada, M., Suzuki, S., Morioka, S., Kutsuna, S., Mizoue, T., Hara, H., Kimura, A., & Ohmagari, N. (2021). Smoking and severe illness in hospitalized COVID-19 patients in Japan. International Journal of Epidemiology. 2. Ishii, J., Kashiwabara, K., Ozaki, Y., Takahashi, H., Kitagawa, F., Nishimura, H., Ishii, H., Iimuro, S., Kawai, H., Muramatsu, T., Naruse, H., Iwata, H., Tanizawa-Motoyama, S., Ito, H., Watanabe, E., Matsuyama, Y., Fukumoto, Y., Sakuma, I., Nakagawa, Y., Hibi, K., Hiro, T., Hokimoto, S., Miyauchi, K., Ohtsu, H., Izawa, H., Ogawa, H., Daida, H., Shimokawa, H., Saito, Y., Kimura, T., Matsuzaki, M., & Nagai, R. (2021). Small Dense Low-Density Lipoprotein Cholesterol and Cardiovascular Risk in Statin-Treated Patients with Coronary Artery Disease. Journal of Atherosclerosis and Thrombosis. 3. Chikuda, H., Koyama, Y., Matsubayashi, Y., Ogata, T., Ohtsu, H., Sugita, S., Sumitani, M., Kadono, Y., Miura, T., Tanaka, S., Akiyama, T., Ando, K., Anno, M., Azuma, S., Endo, K., Endo, T., Fujiyoshi, T., Furuya, T., Hayashi, H., Higashikawa, A., Hiyama, A., Horii, C., Iimoto, S., Iizuka, Y., Ikuma, H., Imagama, S., Inokuchi, K., Inoue, H., Inoue, T., Ishii, K., Ishii, M., Ito, T., Itoi, A., Iwamoto, K., Iwasaki, M., Kaito, T., Kato, T., Katoh, H., Kawaguchi, Y., Kawano, O., Kimura, A., Kobayashi, K., Koda, M., Komatsu, M., Kumagai, G., Maeda, T., Makino, T., Mannoji, C., Masuda, K., Masuda, K., Matsumoto, K., Matsumoto, M., Matsunaga, S., Matsuyama, Y., Mieda, T., Miyoshi, K., Mochida, J., Moridaira, H., Motegi, H., Nakagawa, Y., Nohara, Y., Oae, K., Ogawa, S., Okazaki, R., Okuda, A., Onishi, E., Ono, A., Oshima, M., Oshita, Y., Saita, K., Sasao, Y., Sato, K., Sawakami, K., Seichi, A., Seki, S., Shigematsu, H., Suda, K., Takagi, Y., Takahashi, M., Takahashi, R., Takasawa, E., Takenaka, S., Takeshita, K., Takeshita, Y., Tokioka, T., Tokuhashi, Y., Tonosu, J., Uei, H., Wada, K., Watanabe, M., Yahata, T., Yamada, K., Yasuda, T., Yasui, K., & Yoshii, T. (2021). Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury With Preexisting Cervical Stenosis: A Randomized Clinical Trial. JAMA Network Open. 4. Togano, T., Uemura, Y., Asai, Y., Hayakawa, K., Matsunaga, N., Terada, M., Ohtsu, H., Suzuki, S., Toyoda, A., Hara, H., Sato, R., Ishikane, M., Kinoshita-Iwamoto, N., Hangaishi, A., & Ohmagari, N. (2021). The influence of pre-admission antiplatelet and anticoagulation therapy on the illness severity in hospitalized patients with COVID-19 in Japan. Journal of Infection and Chemotherapy. 5. Hara, H., Uemura, Y., Hayakawa, K., Togano, T., Asai, Y., Matsunaga, N., Terada, M., Ohtsu, H., Kitajima, K., Shimizu, Y., Sato, L., Ishikane, M., Kinoshita-Iwamoto, N., Shibata, T., Kondo, M., Izumi, K., Sugiura, W., & Ohmagari, N. (2021). Evaluation of the efficacy of anticoagulation therapy in reducing mortality in a nationwide cohort of hospitalized patients with coronavirus disease in Japan. International Journal of Infectious Diseases. 6. Bouchi, R., Izumi, K., Ohtsu, H., Miyo, K., Tanaka, S., Satoh-Asahara, N., Hara, K., Odawara, M., Kusunoki, Y., Koyama, H., Onoue, T., Arima, H., Tsushita, K., Watada, H., Kadowaki, T., & Ueki, K. (2021). Prevention of Worsening Diabetes through Behavioral Changes by an IoT-based Self-Monitoring System in Japan (PRISM-J): Study design and rationale for a multicenter, open-label, randomized parallel-group trial. GHM Open. 7. Tsuboi, M., Hachiya, M., Ohtsu, H., Akashi, H., Miyoshi, C., & Umeda, T. (2021). Epidemiology and risk of COVID-19 among travelers at airport and port quarantine stations across Japan: a nationwide descriptive analysis and an individually matched case-control study. Clinical Infectious Diseases. 8. Yamada, G., Hayakawa, K., Matsunaga, N., Terada, M., Suzuki, S., Asai, Y., Ohtsu, H., Toyoda, A., Kitajima, K., Tsuzuki, S., Saito, S., & Ohmagari, N. (2021). Predicting respiratory failure for COVID-19 patients in Japan: a simple clinical score for evaluating the need for hospitalisation. Epidemiology and Infection. 9. Yamada, G., Hayakawa, K., Asai, Y., Matsunaga, N., Ohtsu, H., Hojo, M., Hashimoto, M., Kobayashi, K., Sasaki, R., Okamoto, T., Yanagawa, Y., Katagiri, D., Terada, M., Suzuki, M., Sato, L., Miyazato, Y., Ishikane, M., Morioka, S., Saito, S., & Ohmagari, N. (2021). External validation and update of prediction models for unfavorable outcomes in hospitalized patients with COVID-19 in Japan. Journal of Infection and Chemotherapy. 10. Terada, M., Ohtsu, H., Saito, S., Hayakawa, K., Tsuzuki, S., Asai, Y., Matsunaga, N., Kutsuna, S., Sugiura, W., & Ohmagari, N. (2021). Risk factors for severity on admission and the disease progression during hospitalisation in a large cohort of patients with COVID-19 in Japan. BMJ Open. Omote, K., Yokota, I., Nagai, T., Sakuma, I., Nakagawa, Y., Kamiya, K., Iwata, H., Miyauchi, K., Ozaki, Y., Hibi, K., Hiro, T., Fukumoto, Y., Mori, H., Hokimoto, S., Ohashi, Y., Ohtsu, H., Ogawa, H., Daida, H., Iimuro, S., Shimokawa, H., Saito, Y., Kimura, T., Matsuzaki, M., Nagai, R., & Anzai, T. (2021). High-Density Lipoprotein Cholesterol and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Statins: An Observation from the REAL-CAD Study. Journal of Atherosclerosis and Thrombosis. 11. Kubota, K., Tanaka, N., Miyata, Y., Ohtsu, H., Nakahara, T., Sakamoto, S., Kudo, T., Nishiyama, Y., Tateishi, U., Murakami, K., Nakamoto, Y., Taki, Y., Kaneta, T., Kawabe, J., Nagamachi, S., Kawano, T., Hatazawa, J., Mizutani, Y., Baba, S., Kirii, K., Yokoyama, K., Okamura, T., Kameyama, M., Minamimoto, R., Kunimatsu, J., Kato, O., Yamashita, H., Kaneko, H., Kutsuna, S., Ohmagari, N., Hagiwara, A., Kikuchi, Y., & Kobayakawa, M. (2021). Comparison of 18F-FDG PET/CT and 67Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan. Annals of Nuclear Medicine. 2020年 1. Saito, S., Asai, Y., Matsunaga, N., Hayakawa, K., Terada, M., Ohtsu, H., Tsuzuki, S., & Ohmagari, N. (2020). First and second COVID-19 waves in Japan: A comparison of disease severity and characteristics. The Journal of Infection. Matsunaga, N., Hayakawa, K., Terada, M., Ohtsu, H., Asai, Y., Tsuzuki, S., Suzuki, S., Toyoda, A., Suzuki, K., Endo, M., Fujii, N., Suzuki, M., Saito, S., Uemura, Y., Shibata, T., Kondo, M., Izumi, K., Terada-Hirashima, J., Mikami, A., Sugiura, W., & Ohmagari, N. (2020). Clinical epidemiology of hospitalized patients with COVID-19 in Japan: Report of the COVID-19 REGISTRY JAPAN. Clinical Infectious Diseases. 2. Yamauchi, M., Haranaga, S., Parrott, G., Kinjo, T., Yamashiro, T., Tsubakimoto, M., Ohtsu, H., Ueda, S., & Fujita, J. (2020). Analysis of bronchoalveolar lavage samples collected from 30 patients with drug-induced pneumonitis. Respiratory Investigation. 3. Kinjo, T., Tadokoro, T., Tokushige, A., Zamami, T., Taira, S., Ikehara, Y., Tsuhako, C., Ohtsu, H., Ueda, S., & Kakinohana, M. (2020). Effects of Perioperative Administration of Acetaminophen on Postoperative Shivering: A Randomized, Triple-Blind, Placebo-Controlled Trial. Anesthesia and Analgesia. 4. Shinano, H., Miyazaki, S., Miura, K., Ohtsu, H., Yonemoto, N., Matsuoka, K., Konishi, H., Daida, H., Saito, M., & Sase, K. (2020). Risk Profiling of Cancer Treatment-Related Cardiovascular Disorders in Breast Cancer Patients Who Received Adjuvant Chemotherapy With Trastuzumab. Circulation Reports. 2019年 1. Miyazaki, D., Fukagawa, K., Fukushima, A., Fujishima, H., Uchio, E., Ebihara, N., Shoji, J., Takamura, E., Namba, K., Ohashi, Y., Okamoto, S., Satake, Y., Ohtsu, H., Shimizu, Y., & Inoue, Y. (2019). Air pollution significantly associated with severe ocular allergic inflammatory diseases. Scientific Reports. 2. Nishimoto, M., Ohtsu, H., Marumo, T., Kawarazaki, W., Ayuzawa, N., Ueda, K., Hirohama, D., Kawakami-Mori, F., Shibata, S., Nagase, M., Isshiki, M., Oba, S., Shimosawa, T., & Fujita, T. (2019). Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study. Hypertension Research. 2018年 1. Lee, H. S., Jeon, S. W., Nomura, S., Seto, Y., Kwon, Y. H., Nam, S. Y., Ishibashi, Y., Ohtsu, H., Ohmoto, Y., & Yang, H. M. (2018). Screening biomarker as an alternative to endoscopy for the detection of early gastric cancer: The combination of serum trefoil factor family 3 and pepsinogen. Gastroenterology Research and Practice. 2. Taguchi, I., Iimuro, S., Iwata, H., Takashima, H., Abe, M., Amiya, E., Ogawa, T., Ozaki, Y., Sakuma, I., Nakagawa, Y., Hibi, K., Hiro, T., Fukumoto, Y., Hokimoto, S., Miyauchi, K., Yamazaki, T., Ito, H., Otsuji, Y., Kimura, K., Takahashi, J., Hirayama, A., Yokoi, H., Kitagawa, K., Urabe, T., Okada, Y., Terayama, Y., Toyoda, K., Nagao, T., Matsumoto, M., Ohashi, Y., Kaneko, T., Fujita, R., Ohtsu, H., Ogawa, H., Daida, H., Shimokawa, H., Saito, Y., Kimura, T., Inoue, T., Matsuzaki, M., & Nagai, R. (2018). High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial. Circulation. 3. Miyauchi, K., Kimura, T., Shimokawa, H., Daida, H., Iimuro, S., Iwata, H., Ozaki, Y., Sakuma, I., Nakagawa, Y., Hibi, K., Hiro, T., Fukumoto, Y., Hokimoto, S., Ohashi, Y., Ohtsu, H., Saito, Y., Matsuzaki, M., & Nagai, R. (2018). Rationale and Design of Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy with Pitavastatin in Coronary Artery Disease (REAL-CAD) Trial. International Heart Journal. 2017年 1. Sugiyama, T., Miyo, K., Tsujimoto, T., Kominami, R., Ohtsu, H., Ohsugi, M., Waki, K., Noguchi, T., Ohe, K., Kadowaki, T., Kasuga, M., Ueki, K., & Kajio, H. (2017). Design of and rationale for the Japan Diabetes compREhensive database project based on an Advanced electronic Medical record System (J-DREAMS). Diabetology International. 2. Nakatani, T., Sase, K., Oshiyama, H., Akiyama, M., Horie, M., Nawata, K., Nishinaka, T., Tanoue, Y., Toda, K., Tozawa, M., Yamazaki, S., Yanase, M., Ohtsu, H., Ishida, M., Hiramatsu, A., Ishii, K., & Kitamura, S. (2017). Japanese registry for Mechanically Assisted Circulatory Support: First report. Journal of Heart and Lung Transplantation. 3. Ishibashi, Y., Ohtsu, H., Ikemura, M., Kikuchi, Y., Niwa, T., Nishioka, K., Uchida, Y., Miura, H., Aikou, S., Gunji, T., Matsuhashi, N., Ohmoto, Y., Sasaki, T., Seto, Y., Ogawa, T., Tada, K., & Nomura, S. (2017). Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer. Scientific Reports. 2016年 1. Currie, G., Taylor, A. H. M., Fujita, T., Ohtsu, H., Lindhardt, M., Rossing, P., Boesby, L., Edwards, N. C., Ferro, C. J., Townend, J. N., van den Meiracker, A. H., Saklayen, M. G., Oveisi, S., Jardine, A. G., Delles, C., Preiss, D. J., & Mark, P. B. (2016). Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis. BMC Nephrology. 2. Nakayama, A., Morita, H., Hayashi, N., Nomura, Y., Hoshina, K., Shigematsu, K., Ohtsu, H., Miyata, T., & Komuro, I. (2016). Inverse Correlation Between Calcium Accumulation and the Expansion Rate of Abdominal Aortic Aneurysms. Circulation Journal. 3. Kato, N. P., Kinugawa, K., Sano, M., Kogure, A., Sakuragi, F., Kobukata, K., Ohtsu, H., Wakita, S., Jaarsma, T., & Kazuma, K. (2016). How effective is an in-hospital heart failure self-care program in a Japanese setting? Lessons from a randomized controlled pilot study. Patient Preference and Adherence. 2015年 1. Hara, H., Mihara, M., Ohtsu, H., Narushima, M., Iida, T., & Koshima, I. (2015). Indication of lymphaticovenous Anastomosis for lower limb primary Lymphedema. Plastic and Reconstructive Surgery. 2. Yoshida, Y., Sakamoto, M., Maeda, E., Ohtsu, H., Ota, S., Asamura, H., & Nakajima, J. (2015). Can Image Analysis on High-Resolution Computed Tomography Predict Non-Invasive Growth in Adenocarcinoma of the Lung? Annals of Thoracic and Cardiovascular Surgery. 3. Goto, M., Abe, O., Aoki, S., Hayashi, N., Ohtsu, H., Takao, H., Miyati, T., Matsuda, H., Yamashita, F., Iwatsubo, T., Mori, H., Kunimatsu, A., Ino, K., Yano, K., & Ohtomo, K. (2015). Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study. Radiological Physics and Technology. 2014年 1. Ando, K., Ohtsu, H., Uchida, S., Kaname, S., Arakawa, Y., & Fujita, T. (2014). Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes & Endocrinology. 2. Yamamoto, M., Watanabe, E., Suzuki, T., Yamazaki, T., Ohtsu, H., Ozaki, Y., Ogawa, S., & Yamashita, T. (2014). Association between the quality of life and asymptomatic episodes of paroxysmal atrial fibrillation in the J-RHYTHM II study. Journal of Cardiology. 3. Maeda, E., Katsura, M., Gonoi, W., Yoshikawa, T., Hayashi, N., Ohtsu, H., & Ohtomo, K. (2014). Abnormal Signal Intensities of the Seminal Vesicles in a Screening Population. Journal of Magnetic Resonance Imaging. 4. Sugita, S., Chikuda, H., Kadono, Y., Ohtsu, H., Takeshita, K., Nishino, J., Tohma, S., & Tanaka, S. (2014). Clinical characteristics of rheumatoid arthritis patients undergoing cervical spine surgery: an analysis of National Database of Rheumatic Diseases in Japan. BMC Musculoskeletal Disorders. 5. Terao, R., Yuda, K., Kure, K., Inoue, T., Ohtsu, H., & Yanagi, Y. (2014). Effect of vitreomacular adhesion on antivascular endothelial growth factor therapy for macular edema secondary to branch retinal vein occlusion. Japanese Journal of Ophthalmology. 6. Mihara, M., Hara, H., Furniss, D., Narushima, M., Iida, T., Kikuchi, K., Ohtsu, H., Gennaro, P., Gabriele, G., & Murai, N. (2014). Lymphaticovenular anastomosis to prevent cellulitis associated with lymphoedema. British Journal of Surgery. 2013年 1. Chikuda, H., Ohtsu, H., Ogata, T., Sugita, S., Sumitani, M., Koyama, Y., Matsumoto, M., & Toyama, Y. (2013). Optimal treatment for Spinal Cord Injury associated with cervical canal Stenosis (OSCIS): A study protocol for a randomized controlled trial comparing early versus delayed surgery. Trials. 2. Yoshikawa, T., Hayashi, N., Maeda, E., Matsuda, I., Sasaki, H., Ohtsu, H., & Ohtomo, K. (2013). Peritoneal Fluid Accumulation in Healthy Men and Postmenopausal Women: Evaluation on Pelvic MRI. American Journal of Roentgenology. Yamamoto, T., Yokota, K., Amao, R., Maeno, T., Haga, N., Taguri, M., Ohtsu, H., Ichikawa, Y., Goto, J., & Tsuji, S. (2013). An open trial of long-term testosterone suppression in spinal and bulbar muscular atrophy. Muscle and Nerve. 3. Nakayama, A., Morita, H., Ando, J., Fujita, H., Ohtsu, H., & Nagai, R. (2013). Adverse cardiovascular outcomes associated with concurrent use of clopidogrel or ticlopidine and proton-pump inhibitors in patients undergoing percutaneous coronary intervention. Heart and Vessels. 4. Shirota, Y., Ohtsu, H., Hamada, M., Enomoto, H., & Ugawa, Y. (2013). Supplementary motor area stimulation for Parkinson disease: A randomized controlled study. Neurology. 5. Mihara, M., Hara, H., Narushima, M., Todokoro, T., Iida, T., Ohtsu, H., Murai, N., & Koshima, I. (2013). Indocyanine green lymphography is superior to lymphoscintigraphy in imaging diagnosis of secondary lymphedema of the lower limbs. Journal of Vascular Surgery: Venous and Lymphatic Disorders. 2012年 1. Kato, S., Chikuda, H., Seichi, A., Ohtsu, H., Kimura, A., & Toyama, Y. (2012). Radiographical Risk Factors for Major Intraoperative Blood Loss During Laminoplasty in Patients With Ossification of the Posterior Longitudinal Ligament. Spine. 2. Inuzuka, R., Tatebe, S., Wakiguchi, S., Nakajima, H., Ohtsu, H., Dimopoulos, K., & Aotsuka, H. (2012). B-type natriuretic peptide at the early stage of univentricular circulation reflects inadequate adaptation to volume overload. International Journal of Cardiology. 3. Nakayama, A., Morita, H., Miyata, T., Ando, J., Fujita, H., Ohtsu, H., Akai, T., Hoshina, K., Nagayama, M., Takanashi, S., Sumiyoshi, T., & Nagai, R. (2012). Inverse association between the existence of coronary artery disease and progression of abdominal aortic aneurysm. Atherosclerosis. 4. Kodama, K., Horikoshi, M., Toda, K., Yamada, S., Hara, K., Irie, J., Sirota, M., Morgan, A. A., Chen, R., Ohtsu, H., Maeda, S., Kadowaki, T., & Butte, A. J. (2012). Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 5. Gonoi, W., Akai, H., Hagiwara, K., Akahane, M., Hayashi, N., Maeda, E., Yoshikawa, T., Kiryu, S., Tada, M., Uno, K., Ohtsu, H., Okura, N., Koike, K., & Ohtomo, K. (2012). Meandering Main Pancreatic Duct as a Relevant Factor to the Onset of Idiopathic Recurrent Acute Pancreatitis. PLOS ONE. Maeda, E., Akahane, M., Yoshioka, N., Takao, H., Matsuda, I., Kamiya, K., Hirano, K., Tada, M., Ohtsu, H., Fukushima, N., & Ohtomo, K. (2012). Comparison of CT findings of biliary tract changes with autoimmune pancreatitis and extrahepatic bile duct cholangiocarcinoma. Japanese Journal of Radiology. 6. Shimada, T., Kitamoto, A., Todokoro, A., Ishii-Takahashi, A., Kuwabara, H., Kim, S. Y., Watanabe, K., Minowa, I., Someya, T., Ohtsu, H., Osuga, Y., Kano, Y., Kasai, K., Kato, N., & Sasaki, T. (2012). Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population. Research in Autism Spectrum Disorders. 7. Fujita, M., Ando, K., Kawarazaki, H., Kawarasaki, C., Muraoka, K., Ohtsu, H., Shimizu, H., & Fujita, T. (2012). Sympathoexcitation by Brain Oxidative Stress Mediates Arterial Pressure Elevation in Salt-Induced Chronic Kidney Disease. Hypertension. 2011年 1. Aikou, S., Ohmoto, Y., Gunji, T., Matsuhashi, N., Ohtsu, H., Miura, H., Kubota, K., Yamagata, Y., Seto, Y., Nakajima, A., Goldenring, J. R., Kaminishi, M., & Nomura, S. (2011). Tests for Serum Levels of Trefoil Factor Family Proteins Can Improve Gastric Cancer Screening. Gastroenterology. 2. Chikuda, H., Seichi, A., Takeshita, K., Matsunaga, S., Watanabe, M., Nakagawa, Y., Oshima, K., Sasao, Y., Tokuhashi, Y., Nakahara, S., Endo, K., Uchida, K., Takahata, M., Yokoyama, T., Yamada, K., Nohara, Y., Imagama, S., Hosoe, H., Ohtsu, H., Kawaguchi, H., Toyama, Y., & Nakamura, K. (2011). Acute Cervical Spinal Cord Injury Complicated by Preexisting Ossification of the Posterior Longitudinal Ligament A Multicenter Study. Spine. 3. Gonoi, W., Akai, H., Hagiwara, K., Akahane, M., Hayashi, N., Maeda, E., Yoshikawa, T., Tada, M., Uno, K., Ohtsu, H., Koike, K., & Ohtomo, K. (2011). Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey. Gut. 4. Yamashita, T., Inoue, H., Okumura, K., Kodama, I., Aizawa, Y., Atarashi, H., Ohe, T., Ohtsu, H., Kato, T., Kamakura, S., Kumagai, K., Kurachi, Y., Koretsune, Y., Saikawa, T., Sakurai, M., Sato, T., Sugi, K., Nakaya, H., Hirai, M., Hirayama, A., Fukatani, M., Mitamura, H., Yamazaki, T., Watanabe, E., & Ogawa, S. (2011). Randomized trial of angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II Study). Europace. 5. Watanabe, E., Yamashita, T., Suzuki, S., Saikawa, T., Hirai, M., Yamazaki, T., Ohtsu, H., & Ogawa, S. (2011). Statin Treatment for Patients With Paroxysmal Atrial Fibrillation A J-RHYTHM Substudy. International Heart Journal. 6. Yamamoto, K., Ozaki, H., Takayasu, K., Akehi, N., Fukui, S., Sakai, A., Kodama, M., Shimonagata, T., Kobayashi, K., Ota, M., Horiguchi, Y., Ebisuno, S., Katsube, Y., Yamazaki, T., Ohtsu, H., & Hori, M. (2011). The Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function and Atherosclerosis in Japanese Patients with Mild-to-Moderate Hypertension (J-ELAN) study. Hypertension Research. 2010年 1. Suzuki, R., Horiuchi, S., & Ohtsu, H. (2010). Evaluation of the labor curve in nulliparous Japanese women. American Journal of Obstetrics and Gynecology. 2. Ishiguro, A., Sekine, T., Kakiuchi, S., Nishimura, R., Goishi, K., Tsuchida, S., Ohtsu, H., & Igarashi, T. (2010). Skin and subcutaneous blood flows of very low birth weight infants during the first 3 postnatal days. Journal of Maternal-Fetal & Neonatal Medicine. 3. Ando, K., Ohtsu, H., Arakawa, Y., Kubota, K., Yamaguchi, T., Nagase, M., Yamada, A., & Fujita, T. (2010). Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria. Hypertension Research. 4. Hirasawa, N., Goi, Y., Tanaka, R., Ishihara, K., Ohtsu, H., & Ohuchi, K. (2010). Involvement of prostaglandins and histamine in nickel wire-induced acute inflammation in mice. Journal of Biomedical Materials Research Part A. Yamashita, T., Ogawa, S., Aizawa, Y., Atarashi, H., Inoue, H., Ohe, T., Okumura, K., Ohtsu, H., Kato, T., Kamakura, S., Kumagai, K., Kurachi, Y., Kodama, I., Koretsune, Y., Saikawa, T., Sakurai, M., Sugi, K., Nakaya, H., Hirai, M., Hirayama, A., Fukatani, M., Mitamura, H., Yamazaki, T., & Watanabe, E. (2010). J-RHYTHM II Study: A Randomized Study of Angiotensin II Type 1 Receptor Blocker vs Dihydropiridine Ca Antagonist for Treatment of Paroxysmal Atrial Fibrillation in Patients with Hypertension. Circulation Journal. 2009年 1. Inoue, Y., Sugawara, Y., Tamura, S., Ohtsu, H., Taguri, M., Makuuchi, M., & Kokudo, N. (2009). Validity and feasibility of transient elastography for the transplanted liver in the peritransplantation period. Transplantation. 2. Karasaki, T., Nakajima, J., Murakawa, T., Fukami, T., Yoshida, Y., Kusakabe, M., Ohtsu, H., & Takamoto, S. (2009). Institutional report - Pulmonary Video-assisted thoracic surgery lobectomy preserves more latissimus dorsi muscle than conventional surgery. Interactive Cardiovascular and Thoracic Surgery. 3. Ogawa, S., Yamashita, T., Yamazaki, T., Aizawa, Y., Atarashi, H., Inoue, H., Ohe, T., Ohtsu, H., Okumura, K., Katoh, T., Kamakura, S., Kumagai, K., Kurachi, Y., Kodama, I., Koretsune, Y., Saikawa, T., Sakurai, M., Sugi, K., Tabuchi, T., Nakaya, H., Nakayama, T., Hirai, M., Fukatani, M., & Mitamura, H. (2009). Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation -J-RHYTHM Study-. Circulation Journal. 4. Imamura, M., Okunishi, K., Ohtsu, H., Nakagome, K., Harada, H., Tanaka, R., Yamamoto, K., & Dohi, M. (2009). Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax. 2008年 1. Kunimatsu, N., Aoki, S., Kunimatsu, A., Yoshida, M., Abe, O., Yamada, H., Masutani, Y., Kasai, K., Yamasue, H., Ohtsu, H., & Ohtomo, K. (2008). Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia. Psychiatry Research: Neuroimaging. 2. Nakajima, J., Murakawa, T., Fukami, T., Sano, A., Takamoto, S., & Ohtsu, H. (2008). Postthymectomy myasthenia gravis: Relationship with thymoma and antiacetylcholine receptor antibody. Annals of Thoracic Surgery. 3. Sakurai, Y., Terao, Y., Ichikawa, Y., Ohtsu, H., Momose, T., Tsuji, S., & Mannen, T. (2008). Pure alexia for kana. Characterization of alexia with lesions of the inferior occipital cortex. Journal of the Neurological Sciences. 2007年 1. Yamamoto, K., Miyata, T., Onozuka, A., Koyama, H., Ohtsu, H., & Nagawa, H. (2007). Plantar flexion as an alternative to treadmill exercise for evaluating patients with intermittent claudication. European Journal of Vascular and Endovascular Surgery. 2. Shiga, T., Maemura, K., Imai, Y., Kawanami, D., Takeda, N., Ando, J., Morita, T., Manabe, I., Hayashi, D., Ohtsu, H., Sugiyama, A., Miyamoto, K., Sagara, M., Ito, Y., Yamazaki, T., Hirata, Y., Kodama, T., & Nagai, R. (2007). Long pentraxin 3 is more specific than C-reactive protein as a marker for vascular inflammation. Journal of the American College of Cardiology. 2006年 1. Yamashita, T., Ogawa, S., Aizawa, Y., Atarashi, H., Inoue, H., Ohe, T., Okumura, K., Ohtsu, H., Kato, T., Kamakura, S., Kumagai, K., Kurachi, Y., Kodama, I., Koretsune, Y., Saikawa, T., Sakurai, M., Sugi, K., Nakaya, H., Hirai, M., Hirayama, A., Fukatani, M., Mitamura, H., Yamazaki, T., & Watanabe, E. (2006). Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension - The J-RHYTHM II study design for the investigation of upstream therapy for atrial fibrillation. Circulation Journal. 2. Sakurai, Y., Yagishita, A., Goto, Y., Ohtsu, H., & Mannen, T. (2006). Fusiform type alexia: Pure alexia for words in contrast to posterior occipital type pure alexia for letters. Journal of the Neurological Sciences. 3. Kurita, T., Mitamura, H., Aizawa, Y., Nitta, T., Aonuma, K., Tsuboi, N., Chinushi, M., Kobayashi, Y., Soejima, K., Satomi, K., Furushima, H., Ohe, T., Ogawa, S., Kodama, I., Ohtsu, H., & Yamazaki, T. (2006). Japanese randomized trial for investigation of a combined therapy of amiodarone and implantable cardioverter defibrillator in patients with ventricular tachycardia and fibrillation - The Nippon ICD plus Pharmacologic Option Necessity (NIPPON) study design. Circulation Journal. 2005年 1. Morita, A., Fujiwara, S., Hashi, K., Ohtsu, H., & Kirino, T. (2005). Risk of rupture associated with intact cerebral aneurysms in the Japanese population: a systematic review of the literature from Japan. Journal of Neurosurgery. 1-2 和文原著 2022年 吉原史樹, 大津洋, 中井陸運, 都築慎也, 早川佳代子, 寺田麻里, 松永展明, 安田聡, 小川久雄, 大曲貴夫. (2022). COVID-19 REGISTRY JAPANデータを用いたレニン・アンジオテンシン(RA)抑制薬とCOVID-19重症化との関連性評価. 日本腎臓学会誌, 64(3), 316. 2021年 米本直裕, 松谷司郎, 大津洋, 佐瀬一洋. (2021). レセプトデータベースを用いた自殺・自傷行動の把握. Journal of Epidemiology, 31(Suppl.), 122. 2019年 寺田麻里, 小早川雅男, 大津洋, 齋藤翔, 北川明, 泉和生, 渡邉裕司. (2019). 臨床研究の推進及び円滑化を目的としたひな形作成に関する取り組み―NIH-FDA Clinical Trial Protocol Template と日本の規制に合わせた検討―. 臨床薬理, 50(4), 183-196. 2018年 小早川雅男, 寺田麻里, 大津洋, 泉和生, 齋藤翔, 北條泰輔, 渡邉裕司. (2018). "NIH and FDA Release Protocol Template for Phase 2 and 3 IND/IDE Clinical Trials" の翻訳への取り組み. 臨床薬理, 49(1), 35-38. 2.大津洋, 信濃裕美, 松岡淨, 米本直裕, 佐瀬一洋. (2018). 国際基準からみた臨床研究法の特徴と多施設共同試験の運用―GCPコンパリソン法による重篤な有害事象報告に関する検討―. 臨床評価, 46(2), 303-320. 2016年 田中紀子, 三重野牧子, 黒澤匠雅, 大津洋, 松岡淨. (2016). 医学統計コンサルテーションの実施状況の他施設比較. 薬理と治療, 44(5), 67-71. 2015年 大津洋, 信濃裕美, 佐瀬一洋, 松岡淨, 富野康日己. (2015). 人を対象とする医学研究における重篤な有害事象報告に関する研究 －国際基準からみた統合指針の特徴と多施設共同試験の運用－. 日本臨床試験学会誌, 10(43, s2), s227-238. 2006年 石川洋一, 古川裕之, 小出大介, 大津洋, 木内貴弘. (2006). 電子カルテ導入病院における治験実施の現状と課題. 日本病院薬剤師会雑誌, 42(12), 1577-1580. 1-3 英文総説 2025年 Ohtsu, H., Shimomura, A., & Sase, K. (2025). Breaking the One-Size-Fits-All Approach in Cardio-Oncology: Applying the BEST to Optimize Cardiotoxicity Monitoring. JACC: CardioOncology. 2022年 Ohtsu, H., Shimomura, A., & Sase, K. (2022). Real-World Evidence in Cardio-Oncology. JACC: CardioOncology. |
| 研究者 | 教育活動 | researchmap(JST) |