学校法人順天堂　研究者情報データベース:::研究業績詳細:::

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研究業績詳細

大津洋（オオツヒロシ）

研究テーマ	生物統計学,臨床試験方法論,データサイエンス,レギュラトリーサイエンス
研究業績（論文）	1. 原著論文 1-1 英文原著 1. Kurita T, Mitamura H, Aizawa Y, Nitta T, Aonuma K, Tsuboi N, Chinushi M,Kobayashi Y, Soejima K, Satomi K, Furushima H, Ohe T, Ogawa S, Kodama I, Ohtsu H,Yamazaki T; (Nippon ICD Plus Pharmachologic Option Necessity (NIPPON) Investigators). Japanese randomized trial for investigation of a combined therapy of amiodarone and implantable cardioverter defibrillator in patients with ventricular tachycardia and fibrillation: the Nippon ICD Plus Pharmachologic Option Necessity study design. Circulation Journal.70(3):316-320.,2006 2. Sakurai Y, Yagishita A, Goto Y, Ohtsu H, Mannen T. Fusiform type alexia: pure alexia for words in contrast to posterior occipital type pure alexia for letters. Journal of Neurological Sciences, 247(1),81-92., 2006 3. Yamashita T, Ogawa S, Aizawa Y, Atarashi H, Inoue H, Ohe T, Okumura K, Ohtsu H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki T, Watanabe E; J-RHYTHM II Investigators. Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension. Circulation Journal. 70(10), 1318-1321.,2006 4. Yamamoto K, Miyata T, Onozuka A, Koyama H, Ohtsu H, Nagawa H. Plantar flexion as an alternative to treadmill exercise for evaluating patients with intermittent claudication. European Journal of Vascular & Endovascular Surgery. 33(3),325-329. 2007 5. Sakurai Y, Terao Y, Ichikawa Y, Ohtsu H, Momose T, Tsuji S, Mannen T. Pure alexia for kana. Characterization of alexia with lesions of the inferior occipital cortex. , Journal of the Neurological Sciences. ,268(1-2), 48-59., 2008 6. Nakajima J, Murakawa T, Fukami T, Sano A, Takamoto S, Ohtsu H. Postthymectomy myasthenia gravis: relationship with thymoma and antiacetylcholine receptor antibody. The Annals of Thoracic Surgery. ,86(3),941-945,2008 7. Kunimatsu N, Aoki S, Kunimatsu A, Yoshida M, Abe O, Yamada H, Masutani Y, Kasai K, Yamasue H, Ohtsu H, Ohtomo K. Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia. Psychiatry Research. 164(3),198-205,2008 8. Imamura M, Okunishi K, Ohtsu H, Nakagome K, Harada H, Tanaka R, Yamamoto K,Dohi M. Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax. 64(1),44-49. 2009 9. Karasaki T, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Kusakabe M, Ohtsu H, Takamoto S. Video-assisted thoracic surgery lobectomy preserves more latissimus dorsi muscle than conventional surgery. Interactive Cardiovascular and Thoracic Surgery. 8(3),316-320,2009 10. Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y,Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H; for the J-RHYTHM Investigators. Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation. Circulation Journal. 73(2),242-248,2009 11. Kusunoki T, Matsuoka J, Ohtsu H, Kagimura T and Nakamura H. Relationship between Intraclass and Concordance correlation Coefficients: Similarities and Differences. Japanese Journal of Biometrics,2009, 30(1),35-54 12. Inoue Y, Sugawara Y, Tamura S, Ohtsu H, Taguri M, Makuuchi M, Kokudo N. Validity and feasibility of transient elastography for the transplanted liver in the peritransplantation period. Transplantation. ,88(1),103-109.,2009 13. Ishiguro A, Sekine T, Kakiuchi S, Nishimura R, Goishi K, Tsuchida S, Ohtsu H,Igarashi T. Skin and subcutaneous blood flows of very low birth weight infants　during the first 3 postnatal days. The Journal of Maternal-Fetal & Neonatal Medicine. ,23(6),522-528., 2010 14. Ando K, Ohtsu H, Arakawa Y, Kubota K, Yamaguchi T, Nagase M, Yamada A, Fujita T; Eplerenone combination Versus conventional Agents to Lower blood pressure on　Urinary Antialbuminuric Treatment Effect Study Investigators. Rationale and　design of the Eplerenone combination Versus conventional Agents to Lower blood　pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a　double-blinded randomized placebo-controlled trial to evaluate the　antialbuminuric effects of an aldosterone blocker in hypertensive patients with　albuminuria. Hypertension Research. ,33(6),616-621.,2010 15. Suzuki R, Horiuchi S, Ohtsu H. Evaluation of the labor curve in nulliparous Japanese women. Am J Obstet Gynecol., 203(3) ,225.e1-6, 2010 16. Yamamoto K, Ozaki H, Takayasu K, Akehi N, Fukui S, Sakai A, Kodama M,Shimonagata T, Kobayashi K, Ota M, Horiguchi Y, Ebisuno S, Katsube Y, Yamazaki T,Ohtsu H, Hori M. The effect of losartan and amlodipine on left ventricular　diastolic function and atherosclerosis in Japanese patients with mild-to-moderate　hypertension (J-ELAN) study. Hypertension Research. 34(3),325-330.,2011 17. Yamashita T, Inoue H, Okumura K, Kodama I, Aizawa Y, Atarashi H, Ohe T, Ohtsu　H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Koretsune Y, Saikawa T, Sakurai M,　Sato T, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki　T, Watanabe E, Ogawa S; J-RHYTHM II Investigators. Randomized trial of　angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in　the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II　study). Europace. 13(4),473-479.,2011 18. Watanabe E, Yamashita T, Suzuki S, Saikawa T, Hirai M, Yamazaki T, Ohtsu H, Ogawa S, the J-RHYTHM Investigators Statin Treatment for Patients With Paroxysmal Atrial Fibrillation A J-RHYTHM Substudy , International Heart Journal,52(2), 103-106 ,2011 19. Chikuda H, Seichi A, Takeshita K, Matsunaga S, Watanabe M, Nakagawa Y, Oshima　K, Sasao Y, Tokuhashi Y, Nakahara S, Endo K, Uchida K, Takahata M, Yokoyama T,Yamada K, Nohara Y, Imagama S, Hosoe H, Ohtsu H, Kawaguchi H, Toyama Y, Nakamura K. Acute cervical spinal cord injury complicated by preexisting ossification of　the posterior longitudinal ligament: a multicenter study. Spine ,36(18),1453-1458.,2011 20. Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Tada M, Uno K, Ohtsu H, Koike K, Ohtomo K. Pancreas divisum as a predisposing factor　for chronic and recurrent idiopathic pancreatitis: initial in vivo survey. Gut.,60(8),1103-1108.,2011 21. Aikou S, Ohmoto Y, Gunji T, Matsuhashi N, Ohtsu H, Miura H, Kubota K, Yamagata　Y, Seto Y, Nakajima A, Goldenring JR, Kaminishi M, Nomura S. Tests for serum　levels of trefoil factor family proteins can improve gastric cancer screening.　Gastroenterology. 141(3).837-845.e1-7.2011 22. Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Kiryu S, Tada M, Uno K, Ohtsu H, Okura N, Koike K, Ohtomo K. Meandering main pancreatic duct as a relevant factor to the onset of idiopathic recurrent acute pancreatitis. PLoS One. 2012;7(5):e37652, 2012 23. Inuzuka R, Tatebe S, Wakiguchi S, Nakajima H, Ohtsu H, Dimopoulos K, Aotsuka H. B-type natriuretic peptide at the early stage of univentricular circulation　reflects inadequate adaptation to volume overload, International Journal of Cardiology, 159(2),88-93,2012 24. Fujita M, Ando K, Kawarazaki H, Kawarasaki C, Muraoka K, Ohtsu H, Shimizu H,Fujita T. Sympathoexcitation by brain oxidative stress mediates arterial pressure　elevation in salt-induced chronic kidney disease., Hypertension.,59(1),105-12.,2012 25. Shimada T, Kitamoto A, Todokoro A, Ishii-Takahashi A, Kuwabara H, Kim Soo-Yung, Watanabe K, Minowa I, Someya T, Ohtsu H, Osuga Y, Kano Y, Kasai K, Kato N, Sasaki T , Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population,, Research in Autism Spectrum Disorders,6(1),500-507,2012 26. Maeda E, Akahane M, Yoshioka N, Takao H, Matsuda I, Kamiya K, Hirano K, Tada　M, Ohtsu H, Fukushima N, Ohtomo K. Comparison of CT findings of biliary tract　changes with autoimmune pancreatitis and extrahepatic bile duct　cholangiocarcinoma. Japanese Journal of Radiology . 30(3):227-234.,2012 27. Nakayama A, Morita H, Miyata T, Ando J, Fujita H, Ohtsu H, Akai T, Hoshina K, Nagayama M, Takanashi S, Sumiyoshi T, Nagai R. Inverse association between the existence of coronary artery disease and progression of abdominal aortic　aneurysm., Atherosclerosis. 222(1),278-83.,2012 28. Nakayama A, Morita H, Ando J, Fujita H, Ohtsu H, Nagai R. Adverse cardiovascular outcomes associated with concurrent use of clopidogrel or ticlopidine and proton-pump inhibitors in patients undergoing percutaneous　coronary intervention., Heart and Vessels. 28,292-300,2013 29. Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, Sirota M, Morgan AA, Chen R, Ohtsu H, Maeda S, Kadowaki T, Butte AJ. Expression-based genome-wide　association study links the receptor CD44 in adipose tissue with type 2 diabetes.　 Proceedings of the National Academy of Sciences of the United States of America. ,109(18),7049-7054.,2012 30. Kato S, Chikuda H, Seichi A, Ohtsu H, Kimura A, Toyama Y. Radiographical risk factors for major intraoperative blood loss during laminoplasty in patients with ossification of the posterior longitudinal ligament. Spine, 37(25):E1588-93.,2012 31. Shirota Y, Ohtsu H, Hamada M, Enomoto H, Ugawa Y For Research Committee on rTMS Treatment of Parkinson's Disease. Supplementary motor area stimulation for Parkinson disease: a randomized controlled study. Neurology. 80(15):1400-1405.,2013 32. Yamamoto T, Yokota K, Amao R, Maeno T, Haga N, Taguri M, Ohtsu H, Ichikawa Y,Goto J, Tsuji S. An open trial of long-term testosterone suppression in spinal and bulbar muscular atrophy. Muscle & Nerve. 47(6), 16-22.,2013 33. Yoshikawa T, Hayashi N, Maeda E, Matsuda I, Sasaki H, Ohtsu H, Ohtomo K. Peritoneal fluid accumulation in healthy men and postmenopausal women: evaluation on pelvic MRI. American Journal of Roentgenology. ,200(6):1181-1185.,2013 34. Chikuda H, Ohtsu H, Ogata T, Sugita S, Sumitani M, Koyama Y, Matsumoto M,Toyama Y; OSCIS investigators. Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery. Trials. 14,245.,2013 35. Mihara M, Hara H, Narushima M, Todokoro T, Iida T, Ohtsu H, Murai N, Koshima I. Indocyanine green lymphography is superior to lymphoscintigraphy in imaging diagnosis of secondary lymphedema of the lower limbs. Journal of Vascular Surgery: Venous and Lymphatic Disorders. ,1(2):194-201.,2013 36. Terao R, Yuda K, Kure K, Inoue T, Ohtsu H, Yanagi Y. Effect of vitreomacular adhesion on antivascular endothelial growth factor therapy for macular edema secondary to branch retinal vein occlusion. Japanese Journal of Ophthalmology., 58(2),139-145.,2014 37. Maeda E, Katsura M, Gonoi W, Yoshikawa T, Hayashi N, Ohtsu H, Ohtomo K. Abnormal signal intensities of the seminal vesicles in a screening population. Journal of Magnetic Reson Imaging. ,39(6),1426-1430.,2014 38. Sugita S, Chikuda H, Kadono Y, Ohtsu H, Takeshita K, Nishino J, Tohma S,Tanaka S. Clinical characteristics of rheumatoid arthritis patients undergoing cervical spine surgery: an analysis of National Database of Rheumatic Diseases in Japan. BMC Musculoskeletal Disorders.,15,203.,2014 39. Yamamoto M, Watanabe E, Suzuki T, Yamazaki T, Ohtsu H, Ozaki Y, Ogawa S,Yamashita T; J-RHYTHM II Investigators. Association between the quality of life and asymptomatic episodes of paroxysmal atrial fibrillation in the J-RHYTHM II study. Journal of Cardiology . 64(1),64-69.,2014 40. ndo K, Ohtsu H, Uchida S, Kaname S, Arakawa Y, Fujita T; EVALUATE Study Group. Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol. 2(12):944-53.,2014 41. Mihara M, Hara H, Furniss D, Narushima M, Iida T, Kikuchi K, Ohtsu H, Gennaro P, Gabriele G, Murai N. Lymphaticovenular anastomosis to prevent cellulitis associated with lymphoedema. British Journal of Surgery. 101(11):1391-6.,2014 42. Hara H, Mihara M, Ohtsu H, Narushima M, Iida T, Koshima I. Indication of Lymphaticovenous Anastomosis for Lower Limb Primary Lymphedema. Plastic and Reconstructive Surgery, 136(4):883-893,2015 43. Yoshida Y, Sakamoto M, Maeda E, Ohtsu H, Ota S, Asamura H, Nakajima J. Can Image Analysis on High-Resolution Computed Tomography Predict Non-Invasive Growth　in Adenocarcinoma of the Lung? , Annals of Thoracic Cardiovascular Surgery, 21,8–13,2015 44. Goto M, Abe O, Aoki S, Hayashi N, Ohtsu H, Takao H, Miyati T, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K. Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study. Radiological Physics Technology. ,8(1),64-72,2015 45. Kato NP, Kinugawa K, Sano M, Kogure A, Sakuragi F, Kobukata K, Ohtsu H, Wakita S, Jaarsma T, Kazuma K 　How effective is an in-hospital heart failure self-care program in a Japanese setting? Lessons from a randomized controlled pilot study., Patient preference and adherence, 10 ,171-181,2016 46. Nakayama A, Morita H, Hayashi N, Nomura Y, Hoshina K, Shigematsu K, Ohtsu H, Miyata T, Komuro I. Inverse Correlation Between Calcium Accumulation and the Expansion Rate of Abdominal Aortic Aneurysms. Circulation journal, 80(2),332-339,2016 47. Yagata H, Ohtsu H, Komoike Y, Saji S, Takei H, Nakamura T, Ohashi Y, Iwase T, Shimozuma K Joint symptoms and health-related quality of life in postmenopausal women with breast cancer who completed 5 years of anastrozole., Supportive care in cancer, 24(2) 683-689,2016 48. Currie G, Taylor AH, Fujita T, Ohtsu H, Lindhardt M, Rossing P, Boesby L, Edwards NC, Ferro CJ, Townend JN, van den Meiracker AH, Saklayen MG, Oveisi S, Jardine AG, Delles C, Preiss DJ, Mark PB Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis., BMC nephrology, 17(1) 127,2016 49. Ishibashi Y, Ohtsu H, Ikemura M, Kikuchi Y, Niwa T, Nishioka K, Uchida Y, Miura H, Aikou S, Gunji T, Matsuhashi N, Ohmoto Y, Sasaki T, Seto Y, Ogawa T, Tada K, Nomura S Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer., Scientific reports,7(1) 4846,2017 50. Nakatani T, Sase K, Oshiyama H, Akiyama M, Horie M, Nawata K, Nishinaka T, Tanoue Y, Toda K, Tozawa M, Yamazaki S, Yanase M, Ohtsu H, Ishida M, Hiramatsu A, Ishii K, Kitamura S, J-MACS investigators Japanese registry for Mechanically Assisted Circulatory Support: First report., The Journal of heart and lung transplantation,36(10) ,1087-1096,2017 51. Sugiyama T, Miyo K, Tsujimoto T, et al. Design of and rationale for the Japan Diabetes compREhensive database project based on an Advanced electronic Medical record System (J-DREAMS). Diabetology International. 8(4),375-382.,2017 52. Miyauchi K, Kimura T, Shimokawa H, Daida H, Iimuro S, Iwata H, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Ohashi Y, Ohtsu H, Saito Y, Matsuzaki M, Nagai R, REAL-CAD Trial Investigaters. Rationale and Design of Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy with Pitavastatin in Coronary Artery Disease (REAL-CAD) Trial., International heart journal, 59(2), 315-320,2018 53. Taguchi I, Iimuro S, Iwata H, Takashima H, Abe M, Amiya E, Ogawa T, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Miyauchi K, Yamazaki T, Ito H, Otsuji Y, Kimura K, Takahashi J, Hirayama A, Yokoi H, Kitagawa K, Urabe T, Okada Y, Terayama Y, Toyoda K, Nagao T, Matsumoto M, Ohashi Y, Kaneko T, Fujita R, Ohtsu H, Ogawa H, Daida H, Shimokawa H, Saito Y, Kimura T, Inoue T, Matsuzaki M, Nagai R High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial., Circulation, 137(19), 1997-2009,2018 54. Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, Ito S, Yamamoto T, Tomino Y, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H, Ohtsu H, Ohashi Y, FEATHER Study Investigators. Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial., American journal of kidney diseases ,72(6) ,798-810,2018 55. Nishimoto M, Ohtsu H, Marumo T, Kawarazaki W, Ayuzawa N, Ueda K, Hirohama D, Kawakami-Mori F, Shibata S, Nagase M, Isshiki M, Oba S, Shimosawa T, Fujita T. Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study, Hypertension Research. ,42(4),514-521.,2019 56. Miyazaki D, Fukagawa K, Fukushima A, Fujishima H, Uchio E, Ebihara N, Shoji J, Takamura E, Namba K, Ohashi Y, Okamoto S, Satake Y, Ohtsu H, Shimizu Y, Inoue Y. Air pollution significantly associated with severe ocular allergic inflammatory diseases. Scientific reports, 9(1) 18205,2019 57. Kinjo T, Tadokoro T, Tokushige A, Zamami T, Taira S, Ikehara Y, Tsuhako C, Ohtsu H, Ueda S, Kakinohana M. Effects of Perioperative Administration of Acetaminophen on Postoperative Shivering: A Randomized, Triple-Blind, Placebo-Controlled Trial. Anesthesia & Analgesia. ,130(4),983-990.,2020 58. Yamauchi M, Haranaga S, Parrott G, Kinjo T, Yamashiro T, Tsubakimoto M, Ohtsu H, Ueda S, Fujita J. Analysis of bronchoalveolar lavage samples collected from 30 patients with drug-induced pneumonitis. Respiratory Investigation, 58(3),204-211,2020 59. Matsunaga N, Hayakawa K, Terada M, Ohtsu H, Asai Y, Tsuzuki S, Suzuki S, Toyoda A, Suzuki K, Endo M, Fujii N, Suzuki M, Saito S, Uemura Y, Shibata T, Kondo M, Izumi K, Terada-Hirashima J, Mikami A, Sugiura W, Ohmagari N. Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan: Report of the COVID-19 Registry Japan. Clin Infect Dis. 73(11):e3677-e3689.,2021 60. Kubota K, Tanaka N, Miyata Y, Ohtsu H, Nakahara T, Sakamoto S, Kudo T, Nishiyama Y, Tateishi U, Murakami K, Nakamoto Y, Taki Y, Kaneta T, Kawabe J, Nagamachi S, Kawano T, Hatazawa J, Mizutani Y, Baba S, Kirii K, Yokoyama K, Okamura T, Kameyama M, Minamimoto R, Kunimatsu J, Kato O, Yamashita H, Kaneko H, Kutsuna S, Ohmagari N, Hagiwara A, Kikuchi Y, Kobayakawa M. Comparison of 18F-FDG PET/CT and 67Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan. , Annals of Nuclear Medicine. 35(1),31-46. 2021 61. Saito S, Asai Y, Matsunaga N, Hayakawa K, Terada M, Ohtsu H, Tsuzuki S, Ohmagari N. First and second COVID-19 waves in Japan: A comparison of disease severity and characteristics., Journal of Infection. 82(4),84-123,2021 62. Omote K, Yokota I, Nagai T, Sakuma I, Nakagawa Y, Kamiya K, Iwata H, Miyauchi K, Ozaki Y, Hibi K, Hiro T, Fukumoto Y, Mori H, Hokimoto S, Ohashi Y, Ohtsu H, Ogawa H, Daida H, Iimuro S, Shimokawa H, Saito Y, Kimura T, Matsuzaki M, Nagai R, Anzai T. High-Density Lipoprotein Cholesterol and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Statins: An Observation from the REAL-CAD Study. J Atheroscler Thromb. 29(1):50-68.,2022 63. Terada M, Ohtsu H, Saito S, Hayakawa K, Tsuzuki S, Asai Y, Matsunaga N, Kutsuna S, Sugiura W, Ohmagari N. Risk factors for severity on admission and the disease progression during hospitalisation in a large cohort of patients with COVID-19 in Japan. BMJ Open. 11(6):e047007.,2021 64. Yamada G, Hayakawa K, Asai Y, Matsunaga N, Ohtsu H, Hojo M, Hashimoto M, Kobayashi K, Sasaki R, Okamoto T, Yanagawa Y, Katagiri D, Terada M, Suzuki M, Sato L, Miyazato Y, Ishikane M, Morioka S, Saito S, Ohmagari N. External validation and update of prediction models for unfavorable outcomes in hospitalized patients with COVID-19 in Japan. J Infect Chemother. 27(7):1043-1050.,2021 65. Yamada G, Hayakawa K, Matsunaga N, Terada M, Suzuki S, Asai Y, Ohtsu H, Toyoda A, Kitajima K, Tsuzuki S, Saito S, Ohmagari N. Predicting respiratory failure for COVID-19 patients in Japan: a simple clinical score for evaluating the need for hospitalisation. Epidemiol Infect. 149:e175.,2021 66. Hara H, Uemura Y, Hayakawa K, Togano T, Asai Y, Matsunaga N, Terada M, Ohtsu H, Kitajima K, Shimizu Y, Sato L, Ishikane M, Kinoshita-Iwamoto N, Shibata T, Kondo M, Izumi K, Sugiura W, Ohmagari N. Evaluation of the efficacy of anticoagulation therapy in reducing mortality in a nationwide cohort of hospitalized patients with coronavirus disease in Japan. Int J Infect Dis. 112:111-116.,2021 67. Togano T, Uemura Y, Asai Y, Hayakawa K, Matsunaga N, Terada M, Ohtsu H, Suzuki S, Toyoda A, Hara H, Sato R, Ishikane M, Kinoshita-Iwamoto N, Hangaishi A, Ohmagari N. The influence of pre-admission antiplatelet and anticoagulation therapy on the illness severity in hospitalized patients with COVID-19 in Japan. J Infect Chemother. 27(10):1498-1503.,2021 68. OSCIS investigators; Chikuda H, Koyama Y, Matsubayashi Y, Ogata T, Ohtsu H, Sugita S, Sumitani M, Kadono Y, Miura T, Tanaka S, Akiyama T, Ando K, Anno M, Azuma S, Endo K, Endo T, Fujiyoshi T, Furuya T, Hayashi H, Higashikawa A, Hiyama A, Horii C, Iimoto S, Iizuka Y, Ikuma H, Imagama S, Inokuchi K, Inoue H, Inoue T, Ishii K, Ishii M, Ito T, Itoi A, Iwamoto K, Iwasaki M, Kaito T, Kato T, Katoh H, Kawaguchi Y, Kawano O, Kimura A, Kobayashi K, Koda M, Komatsu M, Kumagai G, Maeda T, Makino T, Mannoji C, Masuda K, Masuda K, Matsumoto K, Matsumoto M, Matsunaga S, Matsuyama Y, Mieda T, Miyoshi K, Mochida J, Moridaira H, Motegi H, Nakagawa Y, Nohara Y, Oae K, Ogawa S, Okazaki R, Okuda A, Onishi E, Ono A, Oshima M, Oshita Y, Saita K, Sasao Y, Sato K, Sawakami K, Seichi A, Seki S, Shigematsu H, Suda K, Takagi Y, Takahashi M, Takahashi R, Takasawa E, Takenaka S, Takeshita K, Takeshita Y, Tokioka T, Tokuhashi Y, Tonosu J, Uei H, Wada K, Watanabe M, Yahata T, Yamada K, Yasuda T, Yasui K, Yoshii T. Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury With Preexisting Cervical Stenosis: A Randomized Clinical Trial. JAMA Netw Open. 4(11):e2133604.,2021 69. Chujo D, Imagawa A, Yasuda K, Abiru N, Awata T, Fukui T, Ikegami H, Kawasaki E, Katsuki T, Kobayashi T, Kozawa J, Nagasawa K, Ohtsu H, Oikawa Y, Osawa H, Shimada A, Shimoda M, Takahashi K, Tsuchiya K, Tsujimoto T, Yasuda H, Hanafusa T, Kajio H. Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design. Diabetol Int. 13(1):288-294.,2021 70. Matsushita Y, Yokoyama T, Hayakawa K, Matsunaga N, Ohtsu H, Saito S, Terada M, Suzuki S, Morioka S, Kutsuna S, Mizoue T, Hara H, Kimura A, Ohmagari N. Smoking and severe illness in hospitalized COVID-19 patients in Japan. Int J Epidemiol. 51(4):1078-1087.,2021 71. Tsuboi M, Hachiya M, Ohtsu H, Akashi H, Miyoshi C, Umeda T. Epidemiology and Risk of Coronavirus Disease 2019 Among Travelers at Airport and Port Quarantine Stations Across Japan: A Nationwide Descriptive Analysis and an Individually Matched Case-Control Study. Clin Infect Dis. 74(9):1614-1622,2022 72. Asai Y, Nomoto H, Hayakawa K, Matsunaga N, Tsuzuki S, Terada M, Ohtsu H, Kitajima K, Suzuki K, Suzuki T, Nakamura K, Morioka S, Saito S, Saito F, Ohmagari N. Comorbidities as Risk Factors for Severe Disease in Hospitalized Elderly COVID-19 Patients by Different Age-Groups in Japan. Gerontology. 68(9):1027-1037.,2022 73. Nomoto H, Suzuki S, Asai Y, Hayakawa K, Gatanaga H, Terada M, Suzuki K, Ohtsu H, Toyoda A, Ohmagari N. Clinical characteristics and prognosis of immunosuppressed inpatients with COVID-19 in Japan. J Infect Chemother. 28(2):224-231.,2022 74. Hiroi Y, Ohtsu H, Uemura Y, Hayakawa K, Asai Y, Kutsuna S, Terada M, Sugiura W, Ohmagari N. Cardiovascular Complications of Hospitalized Patients With Coronavirus Disease 2019 in a Japanese Registry,2022 75. Suzuki M, Hayakawa K, Asai Y, Matsunaga N, Terada M, Ohtsu H, Toyoda A, Takasaki J, Hojo M, Yanagawa Y, Saito S, Yamamoto K, Ide S, Akiyama Y, Suzuki T, Moriya A, Mezaki K, Ohmagari N. Evaluation of the Detection of Pathogens in Hospitalized Patients with COVID-19 at a Tertiary Hospital in Japan. Jpn J Infect Dis. 2022 Jul 22;75(4):419-422. 76. Ohtsu H, Shimomura A, Sase K. Real-World Evidence in Cardio-Oncology: What Is It and What Can It Tell Us? JACC CardioOncol. 2022 Mar 15;4(1):95-97.,2022 77. Chujo D, Kurokawa T, Kawabe A, Takahashi N, Inagaki F, Shinohara K, Hagiwara S, Edamoto Y, Ohmagari N, Hinoshita F, Tajima T, Kajio H, Ohtsu H, Takemura N, Matsumoto S, Shimoda M. Allogeneic islet transplantation with monitoring of islet-specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report. J Diabetes Investig. 13(4):741-745.,2022 78. Yoshihara F, Ohtsu H, Nakai M, Tsuzuki S, Hayakawa K, Terada M, Matsunaga N, Yasuda S, Ogawa H, Ohmagari N. Renin-angiotensin system blocker and the COVID-19 aggravation in patients with hypertension, diabetes, renal failure, Cerebro-cardiovascular disease, or pulmonary disease: Report by the COVID-19 Registry Japan. J Cardiol. 80(4):292-297.,2022 79. Fujioka I, Ohtsu H, Yonemoto N, Sase K, Murashima A. Association between prenatal exposure to antidepressants and neonatal morbidity: An analysis of real-world data from a nationwide claims database in Japan. J Affect Disord. 310:60-67.,2022 80. Matsunaga N, Hayakawa K, Asai Y, Tsuzuki S, Terada M, Suzuki S, Ohtsu H, Kitajima K, Toyoda A, Suzuki K, Suzuki M, Saito S, Uemura Y, Shibata T, Kondo M, Nakamura-Uchiyama F, Yokota K, Saito F, Izumi K, Sugiura W, Ohmagari N. Clinical characteristics of the first three waves of hospitalised patients with COVID-19 in Japan prior to the widespread use of vaccination: a nationwide observational study. Lancet Reg Health West Pac. 22:100421.,2022 81. Kimura Y, Ohtsu H, Yonemoto N, Azuma N, Sase K. Endovascular versus open repair in patients with abdominal aortic aneurysm: a claims-based data analysis in Japan. BMJ Surg Interv Health Technol. 4(1):e000131.,2022 82. Todo T, Ito H, Ino Y, Ohtsu H, Ota Y, Shibahara J, Tanaka M. Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial. Nat Med. 28(8):1630-1639. doi: 10.1038/s41591-022-01897-x. ,2022 83. Todo T, Ino Y, Ohtsu H, Shibahara J, Tanaka M. A phase I/II study of triple-mutated oncolytic herpes virus G47∆ in patients with progressive glioblastoma. Nat Commun. 13(1):4119,2022 84. Ohtsu H, Shimomura A, Miyazaki S, Yonemoto N, Ueda S, Shimizu C, Sase K. "Cardiotoxicity of adjuvant chemotherapy with trastuzumab: a Japanese claim-based data analysis.", Open heart 9 2 ,2022 85. Ishii J, Kashiwabara K, Ozaki Y, Takahashi H, Kitagawa F, Nishimura H, Ishii H, Iimuro S, Kawai H, Muramatsu T, Naruse H, Iwata H, Tanizawa-Motoyama S, Ito H, Watanabe E, Matsuyama Y, Fukumoto Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Hokimoto S, Miyauchi K, Ohtsu H, Izawa H, Ogawa H, Daida H, Shimokawa H, Saito Y, Kimura T, Matsuzaki M, Nagai R. Small Dense Low-Density Lipoprotein Cholesterol and Cardiovascular Risk in Statin-Treated Patients with Coronary Artery Disease. J Atheroscler Thromb. 29(10):1458-1474.,2021 86. Matsushita Y, Yokoyama T, Hayakawa K, Matsunaga N, Ohtsu H, Saito S, Terada M, Suzuki S, Morioka S, Kutsuna S, Mizoue T, Hara H, Kimura A, Ohmagari N. Smoking and severe illness in hospitalized COVID-19 patients in Japan. Int J Epidemiol. 51(4):1078-1087.,2022 87. Saito S, Thao PTN, Ishikane M, Xuan PT, Kutsuna S, Dai HQ, Ohtsu H, Kimura T, Kiyohara H, Shimada Y, Maruoka Y, Thuy PTP, Phu TT, Phuong HK, Tra TT, Duy NLM, Ohara H, Kurosu H, Son NT, Ohmagari N.,"Physical oral care prevents ventilator-associated pneumonia in Vietnam: A prospective interventional study.",Journal of infection and chemotherapy 28 12 1632-1638,2022 88. Egawa M, Kanda E, Ohtsu H, Nakamura T, Yoshida M. Number of Children and Risk of Cardiovascular Disease in Japanese Women: Findings from the Tohoku Medical Megabank. J Atheroscler Thromb. 30(2):131-137.,2023 89. Matsushita Y, Yokoyama T, Hayakawa K, Matsunaga N, Ohtsu H, Saito S, Terada M, Suzuki S, Morioka S, Kutsuna S, Tsuzuki S, Hara H, Kimura A, Ohmagari N. We Should Pay More Attention to Sex Differences to Predict the Risk of Severe COVID-19: Men Have the Same Risk of Worse Prognosis as Women More Than 10 Years Older. J Epidemiol. 33(1):38-44. ,2023 1-2 和文原著 1. 石川洋一、古川裕之、小出大介、大津洋、木内貴弘　電子カルテ導入病院における治験実施の現状と課題　日本病院薬剤師会雑誌,42(12),1577-1580,2006 2. 大津洋、信濃裕美、佐瀬一洋、松岡淨、富野康日己,　人を対象とする医学研究における重篤な有害事象報告に関する研究－国際基準からみた統合指針の特徴と多施設共同試験の運用－, 日本臨床試験学会誌　10,43(s2) s227-38, 2015 3. 田中紀子、三重野牧子、黒澤匠雅、大津洋、松岡淨.　医学統計コンサルテーションの実施状況の他施設比較, 薬理と治療　44(5),67-71,2016 4. 小早川雅男, 寺田麻里, 大津洋, 泉和生, 齋藤翔, 北條泰輔, 渡邉裕司, “NIH and FDA Release Protocol Template for Phase 2 and 3 IND/IDE Clinical Trials” の翻訳への取り組み, 臨床薬理 49(1) 35-38 2018 5. 大津洋, 信濃裕美, 松岡淨, 米本直裕, 佐瀬一洋国際基準からみた臨床研究法の特徴と多施設共同試験の運用―GCPコンパリソン法による重篤な有害事象報告に関する検討―”, 臨床評価 46(2) 303‐320 2018 6. 寺田麻里，小早川雅男，大津洋，齋藤翔，北川明，泉和生，渡邉裕司, 臨床研究の推進及び円滑化を目的としたひな形作成に関する取り組み―NIH-FDA Clinical Trial Protocol Template と日本の規制に合わせた検討―, 臨床薬理 50(4) 183-196 2019 7. 米本直裕, 松谷司郎, 大津洋, 佐瀬一洋レセプトデータベースを用いた自殺・自傷行動の把握, Journal of Epidemiology 31(Suppl.) 122-122 2021 8. 吉原史樹, 大津洋, 中井陸運, 都築慎也, 早川佳代子, 寺田麻里, 松永展明, 安田聡, 小川久雄, 大曲貴夫, COVID-19 REGISTRY JAPANデータを用いたレニン・アンジオテンシン(RA)抑制薬とCOVID-19重症化との関連性評価 ,日本腎臓学会誌 64 3 316-316 2022

研究テーマ

生物統計学,臨床試験方法論,データサイエンス,レギュラトリーサイエンス

研究業績（論文）

1. 原著論文
1-1 英文原著
1. Kurita T, Mitamura H, Aizawa Y, Nitta T, Aonuma K, Tsuboi N, Chinushi M,Kobayashi Y, Soejima K, Satomi K, Furushima H, Ohe T, Ogawa S, Kodama I, Ohtsu H,Yamazaki T; (Nippon ICD Plus Pharmachologic Option Necessity (NIPPON) Investigators). Japanese randomized trial for investigation of a combined therapy of amiodarone and implantable cardioverter defibrillator in patients with ventricular tachycardia and fibrillation: the Nippon ICD Plus Pharmachologic Option Necessity study design. Circulation Journal.70(3):316-320.,2006
2. Sakurai Y, Yagishita A, Goto Y, Ohtsu H, Mannen T. Fusiform type alexia: pure alexia for words in contrast to posterior occipital type pure alexia for letters. Journal of Neurological Sciences, 247(1),81-92., 2006
3. Yamashita T, Ogawa S, Aizawa Y, Atarashi H, Inoue H, Ohe T, Okumura K, Ohtsu H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki T, Watanabe E; J-RHYTHM II Investigators. Randomized study of angiotensin II type 1 receptor blocker vs dihydropiridine calcium antagonist for the treatment of paroxysmal atrial fibrillation in patients with hypertension. Circulation Journal. 70(10), 1318-1321.,2006
4. Yamamoto K, Miyata T, Onozuka A, Koyama H, Ohtsu H, Nagawa H. Plantar flexion as an alternative to treadmill exercise for evaluating patients with intermittent claudication. European Journal of Vascular & Endovascular Surgery. 33(3),325-329. 2007
5. Sakurai Y, Terao Y, Ichikawa Y, Ohtsu H, Momose T, Tsuji S, Mannen T. Pure alexia for kana. Characterization of alexia with lesions of the inferior occipital cortex. , Journal of the Neurological Sciences. ,268(1-2), 48-59., 2008
6. Nakajima J, Murakawa T, Fukami T, Sano A, Takamoto S, Ohtsu H. Postthymectomy myasthenia gravis: relationship with thymoma and antiacetylcholine receptor antibody. The Annals of Thoracic Surgery. ,86(3),941-945,2008
7. Kunimatsu N, Aoki S, Kunimatsu A, Yoshida M, Abe O, Yamada H, Masutani Y, Kasai K, Yamasue H, Ohtsu H, Ohtomo K. Tract-specific analysis of the superior occipitofrontal fasciculus in schizophrenia. Psychiatry Research. 164(3),198-205,2008
8. Imamura M, Okunishi K, Ohtsu H, Nakagome K, Harada H, Tanaka R, Yamamoto K,Dohi M. Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung. Thorax. 64(1),44-49. 2009
9. Karasaki T, Nakajima J, Murakawa T, Fukami T, Yoshida Y, Kusakabe M, Ohtsu H, Takamoto S. Video-assisted thoracic surgery lobectomy preserves more latissimus dorsi muscle than conventional surgery. Interactive Cardiovascular and Thoracic Surgery. 8(3),316-320,2009
10. Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y,Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H; for the J-RHYTHM Investigators. Optimal Treatment Strategy for Patients With Paroxysmal Atrial Fibrillation. Circulation Journal. 73(2),242-248,2009
11. Kusunoki T, Matsuoka J, Ohtsu H, Kagimura T and Nakamura H. Relationship between Intraclass and Concordance correlation Coefficients: Similarities and Differences. Japanese Journal of Biometrics,2009, 30(1),35-54
12. Inoue Y, Sugawara Y, Tamura S, Ohtsu H, Taguri M, Makuuchi M, Kokudo N. Validity and feasibility of transient elastography for the transplanted liver in the peritransplantation period. Transplantation. ,88(1),103-109.,2009
13. Ishiguro A, Sekine T, Kakiuchi S, Nishimura R, Goishi K, Tsuchida S, Ohtsu H,Igarashi T. Skin and subcutaneous blood flows of very low birth weight infants　during the first 3 postnatal days. The Journal of Maternal-Fetal & Neonatal Medicine. ,23(6),522-528., 2010
14. Ando K, Ohtsu H, Arakawa Y, Kubota K, Yamaguchi T, Nagase M, Yamada A, Fujita T; Eplerenone combination Versus conventional Agents to Lower blood pressure on　Urinary Antialbuminuric Treatment Effect Study Investigators. Rationale and　design of the Eplerenone combination Versus conventional Agents to Lower blood　pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a　double-blinded randomized placebo-controlled trial to evaluate the　antialbuminuric effects of an aldosterone blocker in hypertensive patients with　albuminuria. Hypertension Research. ,33(6),616-621.,2010
15. Suzuki R, Horiuchi S, Ohtsu H. Evaluation of the labor curve in nulliparous Japanese women. Am J Obstet Gynecol., 203(3) ,225.e1-6, 2010
16. Yamamoto K, Ozaki H, Takayasu K, Akehi N, Fukui S, Sakai A, Kodama M,Shimonagata T, Kobayashi K, Ota M, Horiguchi Y, Ebisuno S, Katsube Y, Yamazaki T,Ohtsu H, Hori M. The effect of losartan and amlodipine on left ventricular　diastolic function and atherosclerosis in Japanese patients with mild-to-moderate　hypertension (J-ELAN) study. Hypertension Research. 34(3),325-330.,2011
17. Yamashita T, Inoue H, Okumura K, Kodama I, Aizawa Y, Atarashi H, Ohe T, Ohtsu　H, Kato T, Kamakura S, Kumagai K, Kurachi Y, Koretsune Y, Saikawa T, Sakurai M,　Sato T, Sugi K, Nakaya H, Hirai M, Hirayama A, Fukatani M, Mitamura H, Yamazaki　T, Watanabe E, Ogawa S; J-RHYTHM II Investigators. Randomized trial of　angiotensin II-receptor blocker vs. dihydropiridine calcium channel blocker in　the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II　study). Europace. 13(4),473-479.,2011
18. Watanabe E, Yamashita T, Suzuki S, Saikawa T, Hirai M, Yamazaki T, Ohtsu H, Ogawa S, the J-RHYTHM Investigators Statin Treatment for Patients With Paroxysmal Atrial Fibrillation A J-RHYTHM Substudy , International Heart Journal,52(2), 103-106 ,2011
19. Chikuda H, Seichi A, Takeshita K, Matsunaga S, Watanabe M, Nakagawa Y, Oshima　K, Sasao Y, Tokuhashi Y, Nakahara S, Endo K, Uchida K, Takahata M, Yokoyama T,Yamada K, Nohara Y, Imagama S, Hosoe H, Ohtsu H, Kawaguchi H, Toyama Y, Nakamura K. Acute cervical spinal cord injury complicated by preexisting ossification of　the posterior longitudinal ligament: a multicenter study. Spine ,36(18),1453-1458.,2011
20. Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Tada M, Uno K, Ohtsu H, Koike K, Ohtomo K. Pancreas divisum as a predisposing factor　for chronic and recurrent idiopathic pancreatitis: initial in vivo survey. Gut.,60(8),1103-1108.,2011
21. Aikou S, Ohmoto Y, Gunji T, Matsuhashi N, Ohtsu H, Miura H, Kubota K, Yamagata　Y, Seto Y, Nakajima A, Goldenring JR, Kaminishi M, Nomura S. Tests for serum　levels of trefoil factor family proteins can improve gastric cancer screening.　Gastroenterology. 141(3).837-845.e1-7.2011
22. Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Kiryu S, Tada M, Uno K, Ohtsu H, Okura N, Koike K, Ohtomo K. Meandering main pancreatic duct as a relevant factor to the onset of idiopathic recurrent acute pancreatitis. PLoS One. 2012;7(5):e37652, 2012
23. Inuzuka R, Tatebe S, Wakiguchi S, Nakajima H, Ohtsu H, Dimopoulos K, Aotsuka H. B-type natriuretic peptide at the early stage of univentricular circulation　reflects inadequate adaptation to volume overload, International Journal of Cardiology, 159(2),88-93,2012
24. Fujita M, Ando K, Kawarazaki H, Kawarasaki C, Muraoka K, Ohtsu H, Shimizu H,Fujita T. Sympathoexcitation by brain oxidative stress mediates arterial pressure　elevation in salt-induced chronic kidney disease., Hypertension.,59(1),105-12.,2012
25. Shimada T, Kitamoto A, Todokoro A, Ishii-Takahashi A, Kuwabara H, Kim Soo-Yung, Watanabe K, Minowa I, Someya T, Ohtsu H, Osuga Y, Kano Y, Kasai K, Kato N, Sasaki T , Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population,, Research in Autism Spectrum Disorders,6(1),500-507,2012
26. Maeda E, Akahane M, Yoshioka N, Takao H, Matsuda I, Kamiya K, Hirano K, Tada　M, Ohtsu H, Fukushima N, Ohtomo K. Comparison of CT findings of biliary tract　changes with autoimmune pancreatitis and extrahepatic bile duct　cholangiocarcinoma. Japanese Journal of Radiology . 30(3):227-234.,2012
27. Nakayama A, Morita H, Miyata T, Ando J, Fujita H, Ohtsu H, Akai T, Hoshina K, Nagayama M, Takanashi S, Sumiyoshi T, Nagai R. Inverse association between the existence of coronary artery disease and progression of abdominal aortic　aneurysm., Atherosclerosis. 222(1),278-83.,2012
28. Nakayama A, Morita H, Ando J, Fujita H, Ohtsu H, Nagai R. Adverse cardiovascular outcomes associated with concurrent use of clopidogrel or ticlopidine and proton-pump inhibitors in patients undergoing percutaneous　coronary intervention., Heart and Vessels. 28,292-300,2013
29. Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, Sirota M, Morgan AA, Chen R, Ohtsu H, Maeda S, Kadowaki T, Butte AJ. Expression-based genome-wide　association study links the receptor CD44 in adipose tissue with type 2 diabetes.　 Proceedings of the National Academy of Sciences of the United States of America. ,109(18),7049-7054.,2012
30. Kato S, Chikuda H, Seichi A, Ohtsu H, Kimura A, Toyama Y. Radiographical risk factors for major intraoperative blood loss during laminoplasty in patients with ossification of the posterior longitudinal ligament. Spine, 37(25):E1588-93.,2012
31. Shirota Y, Ohtsu H, Hamada M, Enomoto H, Ugawa Y For Research Committee on rTMS Treatment of Parkinson's Disease. Supplementary motor area stimulation for Parkinson disease: a randomized controlled study. Neurology. 80(15):1400-1405.,2013
32. Yamamoto T, Yokota K, Amao R, Maeno T, Haga N, Taguri M, Ohtsu H, Ichikawa Y,Goto J, Tsuji S. An open trial of long-term testosterone suppression in spinal and bulbar muscular atrophy. Muscle & Nerve. 47(6), 16-22.,2013
33. Yoshikawa T, Hayashi N, Maeda E, Matsuda I, Sasaki H, Ohtsu H, Ohtomo K. Peritoneal fluid accumulation in healthy men and postmenopausal women: evaluation on pelvic MRI. American Journal of Roentgenology. ,200(6):1181-1185.,2013
34. Chikuda H, Ohtsu H, Ogata T, Sugita S, Sumitani M, Koyama Y, Matsumoto M,Toyama Y; OSCIS investigators. Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery. Trials. 14,245.,2013
35. Mihara M, Hara H, Narushima M, Todokoro T, Iida T, Ohtsu H, Murai N, Koshima I. Indocyanine green lymphography is superior to lymphoscintigraphy in imaging diagnosis of secondary lymphedema of the lower limbs. Journal of Vascular Surgery: Venous and Lymphatic Disorders. ,1(2):194-201.,2013
36. Terao R, Yuda K, Kure K, Inoue T, Ohtsu H, Yanagi Y. Effect of vitreomacular adhesion on antivascular endothelial growth factor therapy for macular edema secondary to branch retinal vein occlusion. Japanese Journal of Ophthalmology., 58(2),139-145.,2014
37. Maeda E, Katsura M, Gonoi W, Yoshikawa T, Hayashi N, Ohtsu H, Ohtomo K. Abnormal signal intensities of the seminal vesicles in a screening population. Journal of Magnetic Reson Imaging. ,39(6),1426-1430.,2014
38. Sugita S, Chikuda H, Kadono Y, Ohtsu H, Takeshita K, Nishino J, Tohma S,Tanaka S. Clinical characteristics of rheumatoid arthritis patients undergoing cervical spine surgery: an analysis of National Database of Rheumatic Diseases in Japan. BMC Musculoskeletal Disorders.,15,203.,2014
39. Yamamoto M, Watanabe E, Suzuki T, Yamazaki T, Ohtsu H, Ozaki Y, Ogawa S,Yamashita T; J-RHYTHM II Investigators. Association between the quality of life and asymptomatic episodes of paroxysmal atrial fibrillation in the J-RHYTHM II study. Journal of Cardiology . 64(1),64-69.,2014
40. ndo K, Ohtsu H, Uchida S, Kaname S, Arakawa Y, Fujita T; EVALUATE Study Group. Anti-albuminuric effect of the aldosterone blocker eplerenone in non-diabetic hypertensive patients with albuminuria: a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol. 2(12):944-53.,2014
41. Mihara M, Hara H, Furniss D, Narushima M, Iida T, Kikuchi K, Ohtsu H, Gennaro P, Gabriele G, Murai N. Lymphaticovenular anastomosis to prevent cellulitis associated with lymphoedema. British Journal of Surgery. 101(11):1391-6.,2014
42. Hara H, Mihara M, Ohtsu H, Narushima M, Iida T, Koshima I. Indication of Lymphaticovenous Anastomosis for Lower Limb Primary Lymphedema. Plastic and Reconstructive Surgery, 136(4):883-893,2015
43. Yoshida Y, Sakamoto M, Maeda E, Ohtsu H, Ota S, Asamura H, Nakajima J. Can Image Analysis on High-Resolution Computed Tomography Predict Non-Invasive Growth　in Adenocarcinoma of the Lung? , Annals of Thoracic Cardiovascular Surgery, 21,8–13,2015 44. Goto M, Abe O, Aoki S, Hayashi N, Ohtsu H, Takao H, Miyati T, Matsuda H, Yamashita F, Iwatsubo T, Mori H, Kunimatsu A, Ino K, Yano K, Ohtomo K. Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study. Radiological Physics Technology. ,8(1),64-72,2015
45. Kato NP, Kinugawa K, Sano M, Kogure A, Sakuragi F, Kobukata K, Ohtsu H, Wakita S, Jaarsma T, Kazuma K 　How effective is an in-hospital heart failure self-care program in a Japanese setting? Lessons from a randomized controlled pilot study., Patient preference and adherence, 10 ,171-181,2016
46. Nakayama A, Morita H, Hayashi N, Nomura Y, Hoshina K, Shigematsu K, Ohtsu H, Miyata T, Komuro I. Inverse Correlation Between Calcium Accumulation and the Expansion Rate of Abdominal Aortic Aneurysms. Circulation journal, 80(2),332-339,2016
47. Yagata H, Ohtsu H, Komoike Y, Saji S, Takei H, Nakamura T, Ohashi Y, Iwase T, Shimozuma K Joint symptoms and health-related quality of life in postmenopausal women with breast cancer who completed 5 years of anastrozole., Supportive care in cancer, 24(2) 683-689,2016
48. Currie G, Taylor AH, Fujita T, Ohtsu H, Lindhardt M, Rossing P, Boesby L, Edwards NC, Ferro CJ, Townend JN, van den Meiracker AH, Saklayen MG, Oveisi S, Jardine AG, Delles C, Preiss DJ, Mark PB Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis., BMC nephrology, 17(1) 127,2016
49. Ishibashi Y, Ohtsu H, Ikemura M, Kikuchi Y, Niwa T, Nishioka K, Uchida Y, Miura H, Aikou S, Gunji T, Matsuhashi N, Ohmoto Y, Sasaki T, Seto Y, Ogawa T, Tada K, Nomura S Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer., Scientific reports,7(1) 4846,2017
50. Nakatani T, Sase K, Oshiyama H, Akiyama M, Horie M, Nawata K, Nishinaka T, Tanoue Y, Toda K, Tozawa M, Yamazaki S, Yanase M, Ohtsu H, Ishida M, Hiramatsu A, Ishii K, Kitamura S, J-MACS investigators Japanese registry for Mechanically Assisted Circulatory Support: First report., The Journal of heart and lung transplantation,36(10) ,1087-1096,2017
51. Sugiyama T, Miyo K, Tsujimoto T, et al. Design of and rationale for the Japan Diabetes compREhensive database project based on an Advanced electronic Medical record System (J-DREAMS). Diabetology International. 8(4),375-382.,2017
52. Miyauchi K, Kimura T, Shimokawa H, Daida H, Iimuro S, Iwata H, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Ohashi Y, Ohtsu H, Saito Y, Matsuzaki M, Nagai R, REAL-CAD Trial Investigaters. Rationale and Design of Randomized Evaluation of Aggressive or Moderate Lipid Lowering Therapy with Pitavastatin in Coronary Artery Disease (REAL-CAD) Trial., International heart journal, 59(2), 315-320,2018
53. Taguchi I, Iimuro S, Iwata H, Takashima H, Abe M, Amiya E, Ogawa T, Ozaki Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Fukumoto Y, Hokimoto S, Miyauchi K, Yamazaki T, Ito H, Otsuji Y, Kimura K, Takahashi J, Hirayama A, Yokoi H, Kitagawa K, Urabe T, Okada Y, Terayama Y, Toyoda K, Nagao T, Matsumoto M, Ohashi Y, Kaneko T, Fujita R, Ohtsu H, Ogawa H, Daida H, Shimokawa H, Saito Y, Kimura T, Inoue T, Matsuzaki M, Nagai R High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial., Circulation, 137(19), 1997-2009,2018
54. Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, Ito S, Yamamoto T, Tomino Y, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H, Ohtsu H, Ohashi Y, FEATHER Study Investigators. Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial., American journal of kidney diseases ,72(6) ,798-810,2018
55. Nishimoto M, Ohtsu H, Marumo T, Kawarazaki W, Ayuzawa N, Ueda K, Hirohama D, Kawakami-Mori F, Shibata S, Nagase M, Isshiki M, Oba S, Shimosawa T, Fujita T. Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study, Hypertension Research. ,42(4),514-521.,2019
56. Miyazaki D, Fukagawa K, Fukushima A, Fujishima H, Uchio E, Ebihara N, Shoji J, Takamura E, Namba K, Ohashi Y, Okamoto S, Satake Y, Ohtsu H, Shimizu Y, Inoue Y. Air pollution significantly associated with severe ocular allergic inflammatory diseases. Scientific reports, 9(1) 18205,2019
57. Kinjo T, Tadokoro T, Tokushige A, Zamami T, Taira S, Ikehara Y, Tsuhako C, Ohtsu H, Ueda S, Kakinohana M. Effects of Perioperative Administration of Acetaminophen on Postoperative Shivering: A Randomized, Triple-Blind, Placebo-Controlled Trial. Anesthesia & Analgesia. ,130(4),983-990.,2020
58. Yamauchi M, Haranaga S, Parrott G, Kinjo T, Yamashiro T, Tsubakimoto M, Ohtsu H, Ueda S, Fujita J. Analysis of bronchoalveolar lavage samples collected from 30 patients with drug-induced pneumonitis. Respiratory Investigation, 58(3),204-211,2020
59. Matsunaga N, Hayakawa K, Terada M, Ohtsu H, Asai Y, Tsuzuki S, Suzuki S, Toyoda A, Suzuki K, Endo M, Fujii N, Suzuki M, Saito S, Uemura Y, Shibata T, Kondo M, Izumi K, Terada-Hirashima J, Mikami A, Sugiura W, Ohmagari N. Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan: Report of the COVID-19 Registry Japan. Clin Infect Dis. 73(11):e3677-e3689.,2021
60. Kubota K, Tanaka N, Miyata Y, Ohtsu H, Nakahara T, Sakamoto S, Kudo T, Nishiyama Y, Tateishi U, Murakami K, Nakamoto Y, Taki Y, Kaneta T, Kawabe J, Nagamachi S, Kawano T, Hatazawa J, Mizutani Y, Baba S, Kirii K, Yokoyama K, Okamura T, Kameyama M, Minamimoto R, Kunimatsu J, Kato O, Yamashita H, Kaneko H, Kutsuna S, Ohmagari N, Hagiwara A, Kikuchi Y, Kobayakawa M. Comparison of 18F-FDG PET/CT and 67Ga-SPECT for the diagnosis of fever of unknown origin: a multicenter prospective study in Japan. , Annals of Nuclear Medicine. 35(1),31-46. 2021
61. Saito S, Asai Y, Matsunaga N, Hayakawa K, Terada M, Ohtsu H, Tsuzuki S, Ohmagari N. First and second COVID-19 waves in Japan: A comparison of disease severity and characteristics., Journal of Infection. 82(4),84-123,2021
62. Omote K, Yokota I, Nagai T, Sakuma I, Nakagawa Y, Kamiya K, Iwata H, Miyauchi K, Ozaki Y, Hibi K, Hiro T, Fukumoto Y, Mori H, Hokimoto S, Ohashi Y, Ohtsu H, Ogawa H, Daida H, Iimuro S, Shimokawa H, Saito Y, Kimura T, Matsuzaki M, Nagai R, Anzai T. High-Density Lipoprotein Cholesterol and Cardiovascular Events in Patients with Stable Coronary Artery Disease Treated with Statins: An Observation from the REAL-CAD Study. J Atheroscler Thromb. 29(1):50-68.,2022
63. Terada M, Ohtsu H, Saito S, Hayakawa K, Tsuzuki S, Asai Y, Matsunaga N, Kutsuna S, Sugiura W, Ohmagari N. Risk factors for severity on admission and the disease progression during hospitalisation in a large cohort of patients with COVID-19 in Japan. BMJ Open. 11(6):e047007.,2021
64. Yamada G, Hayakawa K, Asai Y, Matsunaga N, Ohtsu H, Hojo M, Hashimoto M, Kobayashi K, Sasaki R, Okamoto T, Yanagawa Y, Katagiri D, Terada M, Suzuki M, Sato L, Miyazato Y, Ishikane M, Morioka S, Saito S, Ohmagari N. External validation and update of prediction models for unfavorable outcomes in hospitalized patients with COVID-19 in Japan. J Infect Chemother. 27(7):1043-1050.,2021
65. Yamada G, Hayakawa K, Matsunaga N, Terada M, Suzuki S, Asai Y, Ohtsu H, Toyoda A, Kitajima K, Tsuzuki S, Saito S, Ohmagari N. Predicting respiratory failure for COVID-19 patients in Japan: a simple clinical score for evaluating the need for hospitalisation. Epidemiol Infect. 149:e175.,2021
66. Hara H, Uemura Y, Hayakawa K, Togano T, Asai Y, Matsunaga N, Terada M, Ohtsu H, Kitajima K, Shimizu Y, Sato L, Ishikane M, Kinoshita-Iwamoto N, Shibata T, Kondo M, Izumi K, Sugiura W, Ohmagari N. Evaluation of the efficacy of anticoagulation therapy in reducing mortality in a nationwide cohort of hospitalized patients with coronavirus disease in Japan. Int J Infect Dis. 112:111-116.,2021
67. Togano T, Uemura Y, Asai Y, Hayakawa K, Matsunaga N, Terada M, Ohtsu H, Suzuki S, Toyoda A, Hara H, Sato R, Ishikane M, Kinoshita-Iwamoto N, Hangaishi A, Ohmagari N. The influence of pre-admission antiplatelet and anticoagulation therapy on the illness severity in hospitalized patients with COVID-19 in Japan. J Infect Chemother. 27(10):1498-1503.,2021
68. OSCIS investigators; Chikuda H, Koyama Y, Matsubayashi Y, Ogata T, Ohtsu H, Sugita S, Sumitani M, Kadono Y, Miura T, Tanaka S, Akiyama T, Ando K, Anno M, Azuma S, Endo K, Endo T, Fujiyoshi T, Furuya T, Hayashi H, Higashikawa A, Hiyama A, Horii C, Iimoto S, Iizuka Y, Ikuma H, Imagama S, Inokuchi K, Inoue H, Inoue T, Ishii K, Ishii M, Ito T, Itoi A, Iwamoto K, Iwasaki M, Kaito T, Kato T, Katoh H, Kawaguchi Y, Kawano O, Kimura A, Kobayashi K, Koda M, Komatsu M, Kumagai G, Maeda T, Makino T, Mannoji C, Masuda K, Masuda K, Matsumoto K, Matsumoto M, Matsunaga S, Matsuyama Y, Mieda T, Miyoshi K, Mochida J, Moridaira H, Motegi H, Nakagawa Y, Nohara Y, Oae K, Ogawa S, Okazaki R, Okuda A, Onishi E, Ono A, Oshima M, Oshita Y, Saita K, Sasao Y, Sato K, Sawakami K, Seichi A, Seki S, Shigematsu H, Suda K, Takagi Y, Takahashi M, Takahashi R, Takasawa E, Takenaka S, Takeshita K, Takeshita Y, Tokioka T, Tokuhashi Y, Tonosu J, Uei H, Wada K, Watanabe M, Yahata T, Yamada K, Yasuda T, Yasui K, Yoshii T. Effect of Early vs Delayed Surgical Treatment on Motor Recovery in Incomplete Cervical Spinal Cord Injury With Preexisting Cervical Stenosis: A Randomized Clinical Trial. JAMA Netw Open. 4(11):e2133604.,2021
69. Chujo D, Imagawa A, Yasuda K, Abiru N, Awata T, Fukui T, Ikegami H, Kawasaki E, Katsuki T, Kobayashi T, Kozawa J, Nagasawa K, Ohtsu H, Oikawa Y, Osawa H, Shimada A, Shimoda M, Takahashi K, Tsuchiya K, Tsujimoto T, Yasuda H, Hanafusa T, Kajio H. Japanese Type 1 Diabetes Database Study (TIDE-J): rationale and study design. Diabetol Int. 13(1):288-294.,2021
70. Matsushita Y, Yokoyama T, Hayakawa K, Matsunaga N, Ohtsu H, Saito S, Terada M, Suzuki S, Morioka S, Kutsuna S, Mizoue T, Hara H, Kimura A, Ohmagari N. Smoking and severe illness in hospitalized COVID-19 patients in Japan. Int J Epidemiol. 51(4):1078-1087.,2021
71. Tsuboi M, Hachiya M, Ohtsu H, Akashi H, Miyoshi C, Umeda T. Epidemiology and Risk of Coronavirus Disease 2019 Among Travelers at Airport and Port Quarantine Stations Across Japan: A Nationwide Descriptive Analysis and an Individually Matched Case-Control Study. Clin Infect Dis. 74(9):1614-1622,2022
72. Asai Y, Nomoto H, Hayakawa K, Matsunaga N, Tsuzuki S, Terada M, Ohtsu H, Kitajima K, Suzuki K, Suzuki T, Nakamura K, Morioka S, Saito S, Saito F, Ohmagari N. Comorbidities as Risk Factors for Severe Disease in Hospitalized Elderly COVID-19 Patients by Different Age-Groups in Japan. Gerontology. 68(9):1027-1037.,2022
73. Nomoto H, Suzuki S, Asai Y, Hayakawa K, Gatanaga H, Terada M, Suzuki K, Ohtsu H, Toyoda A, Ohmagari N. Clinical characteristics and prognosis of immunosuppressed inpatients with COVID-19 in Japan. J Infect Chemother. 28(2):224-231.,2022
74. Hiroi Y, Ohtsu H, Uemura Y, Hayakawa K, Asai Y, Kutsuna S, Terada M, Sugiura W, Ohmagari N. Cardiovascular Complications of Hospitalized Patients With Coronavirus Disease 2019 in a Japanese Registry,2022
75. Suzuki M, Hayakawa K, Asai Y, Matsunaga N, Terada M, Ohtsu H, Toyoda A, Takasaki J, Hojo M, Yanagawa Y, Saito S, Yamamoto K, Ide S, Akiyama Y, Suzuki T, Moriya A, Mezaki K, Ohmagari N. Evaluation of the Detection of Pathogens in Hospitalized Patients with COVID-19 at a Tertiary Hospital in Japan. Jpn J Infect Dis. 2022 Jul 22;75(4):419-422.
76. Ohtsu H, Shimomura A, Sase K. Real-World Evidence in Cardio-Oncology: What Is It and What Can It Tell Us? JACC CardioOncol. 2022 Mar 15;4(1):95-97.,2022
77. Chujo D, Kurokawa T, Kawabe A, Takahashi N, Inagaki F, Shinohara K, Hagiwara S, Edamoto Y, Ohmagari N, Hinoshita F, Tajima T, Kajio H, Ohtsu H, Takemura N, Matsumoto S, Shimoda M. Allogeneic islet transplantation with monitoring of islet-specific cellular autoimmunity in a Japanese patient with type 1 diabetes: A case report. J Diabetes Investig. 13(4):741-745.,2022
78. Yoshihara F, Ohtsu H, Nakai M, Tsuzuki S, Hayakawa K, Terada M, Matsunaga N, Yasuda S, Ogawa H, Ohmagari N. Renin-angiotensin system blocker and the COVID-19 aggravation in patients with hypertension, diabetes, renal failure, Cerebro-cardiovascular disease, or pulmonary disease: Report by the COVID-19 Registry Japan. J Cardiol. 80(4):292-297.,2022
79. Fujioka I, Ohtsu H, Yonemoto N, Sase K, Murashima A. Association between prenatal exposure to antidepressants and neonatal morbidity: An analysis of real-world data from a nationwide claims database in Japan. J Affect Disord. 310:60-67.,2022
80. Matsunaga N, Hayakawa K, Asai Y, Tsuzuki S, Terada M, Suzuki S, Ohtsu H, Kitajima K, Toyoda A, Suzuki K, Suzuki M, Saito S, Uemura Y, Shibata T, Kondo M, Nakamura-Uchiyama F, Yokota K, Saito F, Izumi K, Sugiura W, Ohmagari N. Clinical characteristics of the first three waves of hospitalised patients with COVID-19 in Japan prior to the widespread use of vaccination: a nationwide observational study. Lancet Reg Health West Pac. 22:100421.,2022
81. Kimura Y, Ohtsu H, Yonemoto N, Azuma N, Sase K. Endovascular versus open repair in patients with abdominal aortic aneurysm: a claims-based data analysis in Japan. BMJ Surg Interv Health Technol. 4(1):e000131.,2022
82. Todo T, Ito H, Ino Y, Ohtsu H, Ota Y, Shibahara J, Tanaka M. Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial. Nat Med. 28(8):1630-1639. doi: 10.1038/s41591-022-01897-x. ,2022
83. Todo T, Ino Y, Ohtsu H, Shibahara J, Tanaka M. A phase I/II study of triple-mutated oncolytic herpes virus G47∆ in patients with progressive glioblastoma. Nat Commun. 13(1):4119,2022
84. Ohtsu H, Shimomura A, Miyazaki S, Yonemoto N, Ueda S, Shimizu C, Sase K. "Cardiotoxicity of adjuvant chemotherapy with trastuzumab: a Japanese claim-based data analysis.", Open heart 9 2 ,2022
85. Ishii J, Kashiwabara K, Ozaki Y, Takahashi H, Kitagawa F, Nishimura H, Ishii H, Iimuro S, Kawai H, Muramatsu T, Naruse H, Iwata H, Tanizawa-Motoyama S, Ito H, Watanabe E, Matsuyama Y, Fukumoto Y, Sakuma I, Nakagawa Y, Hibi K, Hiro T, Hokimoto S, Miyauchi K, Ohtsu H, Izawa H, Ogawa H, Daida H, Shimokawa H, Saito Y, Kimura T, Matsuzaki M, Nagai R. Small Dense Low-Density Lipoprotein Cholesterol and Cardiovascular Risk in Statin-Treated Patients with Coronary Artery Disease. J Atheroscler Thromb. 29(10):1458-1474.,2021
86. Matsushita Y, Yokoyama T, Hayakawa K, Matsunaga N, Ohtsu H, Saito S, Terada M, Suzuki S, Morioka S, Kutsuna S, Mizoue T, Hara H, Kimura A, Ohmagari N. Smoking and severe illness in hospitalized COVID-19 patients in Japan. Int J Epidemiol. 51(4):1078-1087.,2022
87. Saito S, Thao PTN, Ishikane M, Xuan PT, Kutsuna S, Dai HQ, Ohtsu H, Kimura T, Kiyohara H, Shimada Y, Maruoka Y, Thuy PTP, Phu TT, Phuong HK, Tra TT, Duy NLM, Ohara H, Kurosu H, Son NT, Ohmagari N.,"Physical oral care prevents ventilator-associated pneumonia in Vietnam: A prospective interventional study.",Journal of infection and chemotherapy 28 12 1632-1638,2022
88. Egawa M, Kanda E, Ohtsu H, Nakamura T, Yoshida M. Number of Children and Risk of Cardiovascular Disease in Japanese Women: Findings from the Tohoku Medical Megabank. J Atheroscler Thromb. 30(2):131-137.,2023
89. Matsushita Y, Yokoyama T, Hayakawa K, Matsunaga N, Ohtsu H, Saito S, Terada M, Suzuki S, Morioka S, Kutsuna S, Tsuzuki S, Hara H, Kimura A, Ohmagari N. We Should Pay More Attention to Sex Differences to Predict the Risk of Severe COVID-19: Men Have the Same Risk of Worse Prognosis as Women More Than 10 Years Older. J Epidemiol. 33(1):38-44. ,2023

1-2 和文原著
1. 石川洋一、古川裕之、小出大介、大津洋、木内貴弘　電子カルテ導入病院における治験実施の現状と課題　日本病院薬剤師会雑誌,42(12),1577-1580,2006
2. 大津洋、信濃裕美、佐瀬一洋、松岡淨、富野康日己,　人を対象とする医学研究における重篤な有害事象報告に関する研究－国際基準からみた統合指針の特徴と多施設共同試験の運用－, 日本臨床試験学会誌　10,43(s2) s227-38, 2015
3. 田中紀子、三重野牧子、黒澤匠雅、大津洋、松岡淨.　医学統計コンサルテーションの実施状況の他施設比較, 薬理と治療　44(5),67-71,2016
4. 小早川雅男, 寺田麻里, 大津洋, 泉和生, 齋藤翔, 北條泰輔, 渡邉裕司, “NIH and FDA Release Protocol Template for Phase 2 and 3 IND/IDE Clinical Trials” の翻訳への取り組み, 臨床薬理 49(1) 35-38 2018
5. 大津洋, 信濃裕美, 松岡淨, 米本直裕, 佐瀬一洋国際基準からみた臨床研究法の特徴と多施設共同試験の運用―GCPコンパリソン法による重篤な有害事象報告に関する検討―”, 臨床評価 46(2) 303‐320 2018
6. 寺田麻里，小早川雅男，大津洋，齋藤翔，北川明，泉和生，渡邉裕司, 臨床研究の推進及び円滑化を目的としたひな形作成に関する取り組み―NIH-FDA Clinical Trial Protocol Template と日本の規制に合わせた検討―, 臨床薬理 50(4) 183-196 2019
7. 米本直裕, 松谷司郎, 大津洋, 佐瀬一洋レセプトデータベースを用いた自殺・自傷行動の把握, Journal of Epidemiology 31(Suppl.) 122-122 2021
8. 吉原史樹, 大津洋, 中井陸運, 都築慎也, 早川佳代子, 寺田麻里, 松永展明, 安田聡, 小川久雄, 大曲貴夫, COVID-19 REGISTRY JAPANデータを用いたレニン・アンジオテンシン(RA)抑制薬とCOVID-19重症化との関連性評価 ,日本腎臓学会誌 64 3 316-316 2022

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大津 洋（オオツ ヒロシ）

大津洋（オオツヒロシ）