学校法人順天堂　研究者情報データベース:::研究業績詳細:::

HOME　＞　研究業績詳細

研究業績詳細

林田眞和（ハヤシダマサカズ）

研究テーマ	麻酔科学一般、心臓血管麻酔一般、オピオイドの薬理、神経障害性疼痛の薬物治療など
研究業績（論文）	1. Umeda M, Hara T, Hayashida M, Niijima T. Role of hydroxyl radical in neutrophil-mediated cytotoxicity. Cell Mol Biol. 1985;31(3):229-33. 2. Du HL, Hayashida M, Hanaoka K．Intraperitoneum insufflation of carbon dioxide increases epidural pressure in laparoscopic cholecystectomy．J　Anesth. 1995;9(4):357-9. 3. Du HL, Hayashida M, Suwa K, Yamada Y, Hanaoka K. Pancuronium increases pulmonary arterial pressure in lung injury. Br J Anaesth. 1996;77(4):526-9. 4. Orii R. Sugawara Y, Hayashida M, Yamada Y, Kubota K, Takayama T, Harihara Y, Makuuchi M, Hanaoka K. Peri-operative blood lactate levels in recipients of living-related liver transplantation. Transplantation. 2000;69(10):2124-7. 5. Orii R，Sugawara Y, Hayashida M, Yamada Y, Chang K, Takayama T, Makuuchi M，Hanaoka K. Effects of amrinone on ischemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. Br J Anaesth. 2000;85(3):389-95. 6. Kato M, Sugawara Y, Orii R, Hayashida M, Kaneko J, Takayama T, Hanaoka K, Makuuchi M, Lactate levels in cirrhotic patients undergoing liver resection. Hepatogastroenterology. 2001;48(40):1106-9. 7. Orii R，Sugawara Y, Hayashida M, Uchida K, Yamada Y, Takayama T, Makuuchi M, Hanaoka K, Lactate is correlated with indocyanine green elimination rate in liver resection for cirrhotic patients. Anesth Analg. 2001;92(4):1064-70. 8. Tomioka T, Sawamura S, Meno A, Hayashida M, Arita H, Hanaoka K. Is the current perception threshold test affected by circadian changes?-A study of healthy volunteers. The Pain Clinic. 2002; 13 (3): 213-215. 9. Hayashida M, Chinzei M, Fujiwara H, Komatsu K, Usui H, Uchida K, Tomioka T, Hanaoka K. Bispectral Index as an indicator of cerebral function during surgery using deep hypothermia and circulatory arrest. Cardiovascular Anesthesia. 2002; 6(1): 9-12, 10. Hayashida M, Chinzei Usui H, M, Komatsu K, Fujiwara H, Yamamoto H, Orii R, Hanaoka K. Frequent occurrence of cerebral ischemic events during pediatric cardiac surgery detected with the Bispectral Index. Cardiovascular Anesthesia. 2002; 6(1): 15-19. 11. Kin N, Hayashida M, Chang K, Uchida K, Hanaoka K. External manual compression of the abdominal aorta to control hemorrhage from a ruptured aneurysm. J Anesth. 2002;16(2):164-6. 12. Hayashida M, Chinzei M, Komatsu K, Yamamoto H, Tamai H, Orii R, Hanaoka K, Murakami A. Detection of cerebral hypoperfusion with bispectral index during paediatric cardiac surgery. Br J Anaesth. 2003;90(5):694-8. 13. Hayashida M, Fukunaga A, Hanaoka K. An animal model for surgical anesthesia and analgesia: characterization with isoflurane anesthesia and remifentanil analgesia. Anesth Analg. 2003;97(5):1340-1346. 14. Hayashida M, Fukunaga A, Hanaoka K. Detection of acute tolerance to the analgesic and nonanalgesic effects of remifentanil infusion in a rabbit model. Anesth Analg. 2003;97(5):1347-1352. 15. Sekiyama H, Sumida T, Hayashida M, Chinzei M, Ide Y, Arita H, Hanaoka K. Postherpetic neuralgia as a risk factor for classic heat stroke. J Anesth. 2003;17(1):57-8. 16. Tomioka T, Hayashida M, Hanaoka K. Pressure alopecia in living donors for liver transplantation. Can J Anaesth. 2004;51(2):186-7. 17. Hanaoka K, Arita H, Hayashida M, Yajima C, Lee SC. Pain control in Asia: Foreword of the round table discussion of pain control. Geriatr Gerontol Int. 2004;4(S1):S237-8. 18. Arita H, Hayashida M, Hanaoka K. Pain control for elderly patients in Japan. Geriatr Gerontol Int. 2004;4(S1):S239-41. 19. Hayashida M, Sato K, Fukunaga A, Fukuda K, Sekiyama H, Sawamura S, Arita H, Hanaoka K. Intravenous infusion of adenosine 5’-triphosphate alleviated a disabling postherpetic neuralgia. J Anesth. 2004;18(1):36-8. 20. Chinzei M, Sawamura S, Hayashida M, Kitamura T, Tamai H, Hanaoka K. The change in Bispectral Index during epileptiform electrical activity under sevoflurane anesthesia in a patient with epilepsy. Anesth Analg. 2004;98(6):1734-1736. 21. Hayashida M, Kin N, Tomioka T, Orii R, Sekiyama H, Usui H, Chinzei M, Hanaoka K. Cerebral ischaemia during cardiac surgery in children detected by combined monitoring of BIS and near-infrared spectroscopy. Brit J Anaesth. 2004;92(5):662-9. 22. Hayashida M, Fukunaga A, Fukuda K, Yamazaki SY, Arita H, Hanaoka K. A rabbit model for evaluation of surgical anesthesia and analgesia: characterization and validation with isoflurane anesthesia and fentanyl analgesia. J Anesth. 2004;18(4):282-91. 23. Hayashida M, Fukuda K, Fukunaga A, Meno A, Sato K, Tarui K, Arita H, Kaneko Y, Hanaoka K. Analgesic effect of intravenous ATP on postherpetic neuralgia in comparison with responses to intravenous ketamine and lidocaine. J Anesth. 2005;19(1):31-5. 24. Bougaki M, Hayashida M, Kin N, Tomioka T, Chinzei M, Hanaoka K. Bispectral Index monitoring during pediatric cardiac surgery: effects of anesthetic doses, hypothermic cardiopulmonary bypass, and age. Cardiovascular Anesthesia. 2005;9(1); 3-9. 25. Hayashida M, Fukuda K, Fukunaga A. Clinical application of adenosine and ATP for pain control. J Anesth. 2005;19(3):225-35. 26. Ikeda K, Ide S, Han W, Hayashida M, Uhl GR, Sora I. How individual sensitivity to opioids can be predicted by gene analyses. Trends Pharmacol Sci. 2005;26(6):311-7. 27. Xu H, Arita H, Hayashida M, Zhang L, Sekiyama H, Hanaoka K. Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats. J Ethnopharmacol. 2006;103(3):392-7. 28. Shu H, Arita H, Hayashida M, Sekiyama H, Hanaoka K. Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine. J Ethnopharmacol. 2006;103(3):398-405. 29. Shu H, Arita H, Hayashida M, Chiba S, Sekiyama H, Hanaoka K. Inhibition of morphine tolerance by processed Aconiti tuber is mediated through activation of kappa opioid receptors. J Ethnopharmacol. 2006;106(2):263-71. 30. Li C, Sekiyama H, Hayashida M, Sumida T, Arita H, Hanaoka K. Effect of repeated topical application of clonidine cream in a rat model of postoperative pain. PAIN RESEARCH. 2006;21(1):25-32. 31. Hayashida M, Fukunaga A, Fukuda K, Sakurai S, Mamiya H, Ichinohe T, Kaneko Y, Hanaoka K. The characteristics of intravenous adenosine-induced antinoception in a rabbit model of acute nociceptive pain: a comparative study with remifentanil. Anesth Analg. 2006;103(4):1004-10. 32. Mizuno J, Akune T, Tsuda T, Fukui Y, Otsuji M, Kin N, Saito Y, Orii R, Hayashida M, Arita H, Hanaoka K: Time course of systolic and diastolic blood pressure decreases during the preintubation period of anesthesia induction: Modelling with a logistic function. J Clin Anesth. 2007;19(7):497-505. 33. Li C, Sekiyama H, Hayashida M, Takeda K, Sumida T, Sawamura S, Yamada Y, Arita H, Hanaoka K. Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. Anesthesiology. 2007;107(3):486-94. 34. Hayashida M, Sekiyama H, Orii R, Chinzei M, Ogawa M, Arita H, Hanaoka K, Takamoto S. Effects of deep hypothermic circulatory arrest with retrograde cerebral perfusion on EEG bispectral index and suppression ratio. J Cardiothorac Vasc Anesth . 2007;21(1):61-7. 35. Shu H, Hayashida M, Chiba S, Sekiyama H, Kitamura T, Hanaoka K, Yamada Y, Arita H Inhibitory effect of processed Aconiti tuber on the development of antinociceptive tolerance to morphine: evaluation with a thermal assay. J Ethnopharmacol. 2007;113(3):560-3. 36. Fukuda K, Hayashida M, Fukunaga A, Kasahara M, Koukita Y, Ichinohe T, Kaneko Y. Pain-relieving effects of intravenous ATP in chronic intractable orofacial pain: an open-label study. J Anesth. 2007;21(1):24-30. 37. Ohshima N, Chinzei M, Mizuno K, Hayashida M, Kitamura T, Shibuya H, Hanaoka K. Transient decreases in Bispectral Index without associated changes in the level of consciousness during photic stimulation in an epileptic patient. Brit J Anaesth. 2007;98(1):100-4. 38. Mizuno J, Gauss T, Suzuki M, Hayashida M, Arita H, Hanaoka K. Encephalopathy and rhabdomyolysis induced by iotrolan during epiduroscopy. Can J Anaesth. 2007;54(1):49-53. 39. Hayashida M, Nagashima M, Satoh Y, Katoh R, Tagami M, Ide S, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Komatsu H, Sora I, Fukuda K, Koga H, Hanaoka K, Ikeda K. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype. Pharmacogenomics. 2008;9(11):1605-16. 40. Shu H, Hayashida M, Arita H, Huang W, Xiao L, Chiba S, Sekiyama H, Hanaoka K. High doses of processed Aconiti tuber inhibit the acute but potentiate the chronic antinociception of morphine. J Ethnopharmacol. 2008;119(2):276-83. 41. Shu H, Hayashida M, Huang W, An K, Chiba S, Hanaoka K, Arita H. The comparison of effects of processed Aconiti tuber, U50488 and MK-801 on the antinociceptive tolerance to morphine. J Ethnopharmacol. 2008;117(1):158-65. 42. Kasai S, Hayashida M, Sora I, Ikeda K. Candidate gene polymorphisms predicting individual sensitivity to opioids. Naunyn Schmiedebergs Arch Pharmacol. 2008;377(4-6):269-81. 43. Oshima N, Chinzei M, Kikuchi E, Hayashida M. Preliminary application of processed electroencephalogram monitoring to differentiate senile dementia from depression. Psychogeriatrics. 2009;9(3):116–20. 44. Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, Nishizawa D, OgaiY, Hasegawa J, Nagashima M, Tagami M, Komatsu H, Sora I, Koga H, Kaneko Y, Ikeda K, Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain. 2009;147(1-3):194-201. 45. Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K. Association between KCNJ6 (GIRK2) gene　polymorphisms and postoperative analgesic requirements after major abdominal surgery. PLoS One. 2009;4(9):e7060. 46. Ariyama J, Hayashida M, Sugimoto Y, Imanishi H, To-oyma Y, Kitamura A. Spread of spinal anesthesia in patients having perianal surgery in the jackknife position: Effects of baricity of 0.5% bupivacaine and posture during and after induction of spinal anesthesia. J Clin Anesth. 2009;21(6):408-13. 47. Ariyama J, Hayashida M, Shibata K, Sugimoto Y, Imanishi H, O-oi Y, Kitamura A. Risk factors for the development of reversible psychomotor dysfunction following prolonged isoflurane inhalation in general intensive care unit. J Clin Anesth. 2009;21(8):567-73. 48. Handa T, Fukuda K, Hayashida M, Koukita Y, Ichinohe T, Kaneko Y. Effects of intravenous adenosine 5'-triphosphate on intraoperative hemodynamics and postoperative pain in patients undergoing major orofacial surgery: a double-blind placebo-controlled study. J Anesth. 2009;23(3):315-22. 49. Chiba S, Hayashida M, Yoshikawa M, Shu H, Nishiyama T, Yamada Y. Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine. J Anesth. 2009;23(1):99-107. 50. Tsukamoto S, Maruyama K, Nakagawa H, Iwase Y, Kitamura A, Hayashida M. Fatal hyperkalemia due to rapid red cell transfusion in a critically ill patient. J Nippon Med Sch. 2009;76(5):258-64. 51. Imanishi H, Kitamura A, Maruyama K, Ariyama J, Nakagawa H, Nishibe S, Hayashida M, Usuda Y. Suspected recurrent anaphylaxia in different forms during general anesthesia. J Anesth. 2010;24(1):143-5. 52. Ariyama J, Imanishi H, Nakagawa H, Kitamura A, Hayashida M. Epicardial hematoma and myocardial ischemia following application of Starfish stabilizer: an uncommon complication of the device. J Anesth. 2010;24(5):801-2. 53. Azuma K, Maruyama K, Imanishi H, Nakagawa H, Kitamura A, Hayashida M. Difficult management of anticoagulation with argatroban in a patient undergoing on-pump cardiac surgery. J Cardiothorac Vasc Anesth. 2010;24(5):831-3. 54. Maruyama K, Nishikawa Y, Nakagawa H, Ariyama J, Kitamura A, Hayashida M. Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil? J Anesth. 2010;24(2):293-6. 55. Shu H, Arita H, Hayashida M, Zhang L, An K, Huang W, Hanaoka K. Anti-hypersensitivity effects of Shu-jing-huo-xue-tang, a Chinese herbal medicine, in CCI-neuropathic rats. J Ethnopharmacol. 2010;131(2):464-70. 56. Maruyama K, Tsukamoto S, Ohno S, Kobayashi K, Nakagawa H, Kitamura A, Hayashida M. Effect of cardiopulmonary resuscitation on intubation using a Macintosh laryngoscope, the AirWay Scope, and the gum elastic bougie: A manikin study. Resuscitation. 2010;81(8):1014-8. 57. Aoki J, Hayashida M, Tagami M, Nagashima M, Fukuda KI, Nishizawa D, Ogai Y, Kasai S, Ikeda K, Iwahashi K. Association between 5-hydroxytryptamine 2A receptor gene polymorphism and postoperative analgesic requirements after major abdominal surgery. Neurosci Lett. 2010;479(1):40-3. 58. Fukuda K, Hayashida M, Ikeda K, Koukita Y, Ichinohe T, Kaneko Y. Diversity of opioid requirements for postoperative pain control following oral surgery--is it affected by polymorphism of the μ-opioid receptor? Anesth Prog. 2010;57(4):145-9. 59. Nishizawa D, Hayashida M, Nagashima M, Koga H, Ikeda K. Genetic polymorphisms and human sensitivity to opioid analgesics. Methods Mol Biol. 2010:617:395-420. 60. Maruyama K, Nakagawa H, Imanishi H, Kitamura A, Hayashida M. Comparison of postoperative pharyngeal morbidity using the Macintosh laryngoscope or AirWay Scope after mastectomy. J Anesth. 2011;25(5):773-6. 61. Chinzei M, Kitamura T, Oshima N, Hayashida M, Komori C, Kin N, Sekiyama H, Suzuki M, Yamada Y. Simultaneous monitoring of consciousness and hemodynamics during therapeutic total spinal anesthesia. Jpn J Clin Physiol. 2011; 41(6): 209-14. 62. Shu H, Hayashida M, Arita H, Huang W, Zhang H, An K, Wu G, Hanaoka K. Pentazocine-induced antinociception is mediated mainly by μ-opioid receptors and compromised by κ-opioid receptors in mice. J Pharmacol Exp Ther. 2014;349(2):347. 63. Hanaoka K, Hayashida M, Arita H, Ide Y, Tagami M, Nagase M. Drug challenge tests for diagnosis and treatments of intractable chronic pain. ScienceMED. 2011;2(4):279-82. 64. Nakagawa H, Maruyama K, Hayashida M, Kakoi H, Ohki R, Takenouchi K, Kitamura A. Comparison of tracheal intubation using Macintosh and Airtraq laryngoscopes during cardiopulmonary resuscitation with or without cervical immobilization：a manikin study. Anesthesia and Resuscitation. 2012;48(4):93-8. 65. Maruyama K, Mieda T, Nakagawa H, Kitamura A, Hayashida M. The effect of light-emitting diodes on intubation with Vital View plastic laryngoscope blade during a simulated resuscitation. Am J Emerg Med. 2012;30(1):242-4. 66. Sugasawa Y, Hayashida M, Yamaguchi K, Kajiyama Y, Inada E. Usefulness of stroke volume index obtained with the FloTrac/ Vigileo system for the prediction of acute kidney injury after radical esophagectomy. Ann Surg Oncol. 2013;20(12):3992-8. 67. Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K. Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. PLoS One. 2013;8(8):e70694. 68. Kasagi Y, Hayashida M, Sugasawa Y, Kikuchi I, Yamaguchi K, Okutani R, Takeda S, Inada E.　Antiemetic effect of naloxone in combination with dexamethasone and droperidol in patients undergoing laparoscopic gynecological surgery. J Anesth. 2013;27(6):879-84. 69. Mieda T, Hayashida M, Maruyama K, Nakagawa H, Yoshikawa H, Terao K, Imanishi H, Ariyama J, Kitamura A. Pulmonary Gas Embolism as a Potential Cause of Hypoxia Immediately After Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2013;27(5):951-4. 70. Sugasawa Y, Hayashida M, Inada E. Discrete subaortic stenosis diagnosed intraoperatively. J Anesth. 2014;28(2):311. 71. Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K. Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. Mol Pain. 2014:10:75. 72. Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K. Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence. J Pharmacol Sci. 2014;126(3):253-63. 73. Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K.　Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry. 2014;19(1):55-62. 74. Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Mol Brain. 2015:8:50. 75. Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K. Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements. J Pharmacol Sci. 2015;127(3):391-3. 76. Yoshida K, Nishizawa D, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K. Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. PLoS One. 2015;10(1):e0116885. 77. Mieda T, Nishizawa D, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M. Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. Pharmacogenomics. 2016;17(2):133-45. 78. Kawagoe I, Hayashida M, Suzuki K, Kitamura Y, Oh S, Satoh D, Inada E. Anesthetic management of patients undergoing right lung surgery after left upper lobectomy: selection of tubes for one-lung ventilation (OLV) and oxygenation during OLV. J Cardiothorac Vasc Anesth. 2016;30(4):961-6. 79. Ishibashi C, Hayashida M, Sugasawa Y, Yamaguchi K, Tomita N, Kajiyama Y, Inada E. Effects of dexmedetomidine on hemodynamics and respiration in intubated, spontaneously breathing patients after endoscopic submucosal dissection for cervical esophageal or pharyngeal cancer. J Anesth. 2016;30(4):628-36. 80. Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K. Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery. J Pain. 2016;17(10):1126-1134. 81. Mukaida H, Hayashida M, Matsushita S, Yamamoto M, Nakamura A, Amano A. Brain natriuretic peptide (BNP) may play a major role in risk stratification based on cerebral oxygen saturation by near-infrared spectroscopy in patients undergoing major cardiovascular surgery. PLoS One. 2017;12(7):e0181154. 82. Kawagoe I, Hayashida M, Nozumi Y, Banno T, Hirayama S, Suzuki K, Satoh D, Naito Y, Inada E A Combination of a partial anomalous pulmonary venous connection (PAPVC) and a lung tumor requiring pulmonary resection. J Cardiothorac Vasc Anesth. 2017;31(1):274-278. 83. Kawagoe I, Hayashida M, Satoh D, Suzuki K, Inada E. Ventilation failure after lateral jackknife positioning for robot-assisted lung cancer surgery in a patient after lingula-sparing left upper lobectomy. JA Clin Rep. 2018;4:51. 84. Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda KI, Kitamura A, Hayashida M, Ikeda K. Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy. Pharmacogenomics. 2018;19:113-127. 85. Yamamoto M, Hayashida M, Kakemizu-Watanabe M, Ando N, Mukaida H, Kawagoe I, Yusuke S, Inada E. B-type natriuretic peptide and hemoglobin are two major factors significantly associated with baseline cerebral oxygen saturation measured using the INVOS oximeter in patients undergoing off-pump coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2018;32:187-196. 86. Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda KI, Ikeda K. Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test. Neuropsychopharmacol Rep. 2018;38:86-91. 87. Kawagoe I, Hayashida M, Satoh D, Inada E. Intercostal misplacement of a thoracic epidural catheter discovered during lung cancer surgery: a case report. JA Clin Rep. 2019;5:44. 88. Niimi N, Kataoka K, Hayashida M, Inada E. The dynamic collapse of the trachea during anesthesia for a pediatric patient with a large anterior mediastinal mass: A case report. Clin Case Rep. 2020;8(9):1814-15. 89. Kawagoe I, Satoh D, Mitaka C, Fukuda M, Kochiyama T, Hayashida M. Specific airway management for SVC replacement during giant anterior mediastinal tumor resection. JA Clin Rep. 2020;6(1):70. 90. Mukaida H, Hayashida M, Matsushita S, Endo D, Oishi A, Shimada A, Hata H, Kajimoto K, Yamamoto T, Amano A. Free triiodothyronine (fT3) and B-type natriuretic peptide (BNP) predict in-hospital mortality after valve surgery. Gen Thorac Cardiovasc Surg. 2020;68(6):585-95. 91. Nishizawa D, Iseki M, Arita H, Hanaoka K, Yajima C, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Hayashida M, Ikeda K. Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia. Mol Pain. 2021;17:1744806921999924. 92. Inoue R, Nishizawa D, Hasegawa J, Nakayama K, Fukuda K, Ichinohe T, Mieda T, Tsujita M, Nakagawa H, Kitamura A, Sumikura H, Ikeda K, Hayashida M. Effects of rs958804 and rs7858836 single-nucleotide polymorphisms of the ASTN2 gene on pain-related phenotypes in patients who underwent laparoscopic colectomy and mandibular sagittal split ramus osteotomy. Neuropsychopharmacol Rep. 2021;41(1):82-90. 93. Kawagoe I, Hayashida M, Satoh D, Kochiyama T, Fukuda M, Kishii J. Postoperative analgesia in patients undergoing robot-assisted thoracic surgery: a comparison between thoracic epidural analgesia and intercostal nerve block combined with intravenous patient-controlled analgesia. Ann Palliat Med. 2021;10:1985-93. 94. Fukuda M, Kawagoe I, Kochiyama T, Ando N, Kudoh O, Satoh D, Hayashida M. Well leg compartment syndrome following robot-assisted radical cystectomy in the lithotomy position: a case report. JA Clin Rep. 2021;7:13. 95. Kuroda Y, Nonaka M, Kamikubo Y, Ogawa H, Murayama T, Kurebayashi N, Sakairi H, Miyano K, Komatsu A, Dodo T, Nakano-Ito K, Yamaguchi K, Sakurai T, Iseki M, Hayashida M, Uezono Y. Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors. Biomed Pharmacother. 2021;141:111800. 96. Kawagoe I, Hayashida M, Satoh D, Kudoh O, Fukuda M, Kochiyama T, Kishii J, Mitaka C. Unique strategy using a standard double lumen tube during one lung ventilation for successful intraoperative airway management in patients with a giant bulla on the ventilated side: case series. J Anesth. 2021;35(5):761-6. 97. Yamaguchi A, Kawagoe1 I, Inoue S, Kochiyama T, Fukuda M, Saito M, Hayashida M. Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial. J Thorac Dis 2021;13:5430-8. 98. Kadokura Y, Hayashida M, Kakemizu-Watanabe M, Yamamoto M, Endo D, Oishi A, Nakanishi K, Hata H. Cerebral oxygen saturation (rSO 2) during cardiopulmonary bypass (CPB) measured using the INVOS oximeter closely correlates with baseline rSO2. J Artif Organs. 2021;24(4):433-41. 99. Mitaka C, Kawagoe I, Satoh D, Hayashida M. Effect of recombinant human soluble thrombomodulin on coagulation-related variables in patients with sepsis-induced disseminated intravascular coagulation: a retrospective observational study. Clin Appl Thromb Hemost. 2021;27:10760296211050356. 100. Ohka S, Yamada S, Nishizawa D, Fukui Y, Arita H, Hanaoka K, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Hayashida M, Fukushi S, Saijo M, Ikeda AK. Heparan sulfate 3- O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus-mediated fusogenic activity. Mol Pain. 2021;17:17448069211052171. 101. Karasawa Y, Miyano K, Fujii H, Mizuguchi T, Kuroda Y, Nonaka M, Komatsu A, Ohshima K, Yamaguchi M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M. In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways. Molecules. 2021;26(19):6079. 102. Nakamura K, Sugita A, Sekiya S, Kitamura A, Mitsuhata H, Yamaguchi K, Hayashida M. Paths of thoracic epidural catheters in children undergoing the Nuss procedure for pectus excavatum repair. J Anesth. 2022;36(3):335-340. 103. Furuta Y, Nakamura Y, Tokida M, Ichikawa K, Okada H, Hayashida M, Okubo M, Ohsaka A. Implementation of an electronic identification system in the setting of perioperative autologous cell salvage transfusion: Experience at a university hospital. Transfus Apher Sci. 2022;61(1):103281. 104. Kasai S, Nishizawa D, Hasegawa J, Fukuda KI, Ichinohe T, Nagashima M, Hayashida M, Ikeda K. Short Tandem Repeat Variation in the CNR1 Gene Associated With Analgesic Requirements of Opioids in Postoperative Pain Management. Front Genet. 2022;13:815089. 105. Nishizawa D, Nagashima M, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Fukuda KI, Ichinohe T, Hayashida M, Ikeda K. Associations between the C3orf20 rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and C3orf20 Gene Expression in the Brain. Pharmaceutics. 2022;14(4):727. 106. Inada M, Kawagoe I, Kudoh O, Satoh D, Mitaka C, Hayashida M. Dilutional acidosis during whole lung lavage under general anesthesia due to excessive absorption of normal saline. JA Clin Rep. 2022;8(1):30. 107. Kawagoe I, Hayashida M, Satoh D, Mitaka C. Comparison of desflurane and propofol in the speed and the quality of emergence from anesthesia in patients undergoing lung cancer surgery-a prospective, randomized study. Transl Cancer Res. 2022;11(4):736-44. 108. Kageshima Y, Inada E, Yamaguchi K, Hayashida M. Comparison Between Effects of Amenamevir and Famciclovir on Intensities of Acute Pain and the Incidence of Postherpetic Neuralgia in Adult Patients with Herpes Zoster. Juntendo Medical Journal. 2022;68(2):120-30. 109. Komatsu A, Miyano K, Nakayama D, Mizobuchi Y, Uezono E, Ohshima K, Karasawa Y, Kuroda Y, Nonaka M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M. Novel Opioid Analgesics for the Development of Transdermal Opioid Patches That Possess Morphine-Like Pharmacological Profiles Rather Than Fentanyl: Possible Opioid Switching Alternatives Among Patch Formula. Anesth Analg. 2022;134(5):1082-93. 110. Takeuchi K, Hayashida M, Kudoh O, Niimi N, Kataoka K, Kakemizu-Watanabe M, Yamamoto M, Hara A, Kawagoe I, Yamaguchi K. Continuing versus withholding angiotensin receptor blocker (ARB)/calcium channel blocker (CCB) combination tablets during perioperative periods in patients undergoing minor surgery: a single-blinded randomized controlled trial. J Anesth. 2022;36(3):374-82. 111. Yamazaki S, Yamaguchi K, Someya A, Nagaoka I, Hayashida M. Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells. Int J Mol Sci. 2022;23(17):10096. 112. Yamaguchi M, Miyano K, Hirayama S, Karasawa Y, Ohshima K, Uezono E, Komatsu A, Nonaka M, Fujii H, Yamaguchi K, Iseki M, Hayashida M, Uezono Y. Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways. Molecules. 2022;27(20):7065. 113. Umeno Y, Ishikawa S, Kudoh O, Hayashida M. Effects of the Multidisciplinary Preoperative Clinic on the Incidence of Elective Surgery Cancellation. J Med Syst. 2022;46(12):95. 114. Miyake Y, Fujiwara K, Kataoka K, Ochi T, Seo S, Koga H, Lane GJ, Nishimura K, Hayashida M, Yamataka A. Retroperitoneoscopic Surgery in Children Does Not Cause Pathological Desaturation in Cerebral/Renal Oxygenation on Near-Infrared Spectroscopy Compared with Laparoscopic and Thoracoscopic Surgery. J Laparoendosc Adv Surg Tech A. 2022;32(12):1260-4. 115. Kudoh O, Hayashida M. Historical Changes in Anesthesia Practice for Laparoscopic Gynecological Surgery at Juntendo University Hospital – A Retrospective Observational Study Focusing on Factors Affecting the Incidence of Postoperative Nausea and Vomiting. Juntendo Medical Journal. 2022;68(6):582-9. 116. Aoki Y, Nishizawa D, Ohka S, Kasai S, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Setsuro Ogawa S, Hiranuma A, Hasegawa J, Nakayama K, Ebata Y, Ichinohe T, Hayashida M, Fukuda K-I, Kazutaka Ikeda K. Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain. Int J Mol Sci. 2023 Jan 5;24(2):1028. 117. Kusano Y, Kawagoe I, Yamaguchi A, Kishii J, Morita Y, Fukuda M, Kochiyama T, Hayashida M. Postoperative analgesia following robot-assisted thoracic surgery for mediastinal disease: retrospective comparative study of general anesthesia alone, combined with epidural analgesia, and with ultrasound-guided thoracic paraspinal block. Ann Transl Med. 2023;11(5):206. 118. Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai, S, Hasegawa J, Nakayama K, Ebata Y, Kitamura A, Shimizu H, Takashima T, Masakazu Hayashida M, Ikeda K. Genome-Wide Association Study Identifies Genetic Polymorphisms Associated with Estimated Minimum Effective Concentration of Fentanyl in Patients Undergoing Laparoscopic-Assisted Colectomy. Int J Mol Sci. 2023;24(9):8421. 119. Uezono E, Mizobuchi Y, Miyano K, Ohbuchi K, Murata H, Komatsu A, Manabe S, Nonaka M, Hirokawa T, Yamaguchi K, Iseki M, Uezono Y, Hayashida M, Kawagoe I. Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses. Int J Mol Sci. 2023;24(9):8369. 120. Ikeda M, Hayashida M, Kadokura Y, Kakemizu-Watanabe M, Yamamoto M, Miyazaki S, Gong C, Ishikawa S. Associations among preoperative transthoracic echocardiography variables and cerebral near-infrared spectroscopy values at baseline before anesthesia in patients undergoing cardiac surgery: a retrospective observational study. Heart Vessels. 2023;38(6):839-48. 121. Nishizawa D, Morino R, Inoue R, Ohka S, Kasai S, Hasegawa J, Ebata Y, Nakayama K, Sumikura H, Hayashida M, Yokota M, Ikeda K. Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting. Cancers (Basel). 2023 26;15(19):4729. 122. Umeno Y, Ishikawa S, Kudoh O, Nojiri S, Deshipande G, Inada E, Hayashida M. Introduction of a Multidisciplinary Preoperative Clinic at Juntendo University Hospital - A Retrospective Observational Study Focusing on Effects of Preoperative Interventions on Clinical Outcomes. Juntendo Medical Journal. 2023;69(5):378-87. 123. Mitaka C, Teranishi K, Wakita M, Misawa S, Nojiri S, Satoh D, Hayashida M. Incidences of and risk factors for clinical and subclinical contrast-associated acute kidney injury in patients who underwent neuroendovascular surgery. Neuroradiol J. 2023;36(5):601-609. 124. Satoh D, Takeuchi K, Kawagoe I, Kisii J, Kudoh O, Hayashida M. Prognosis for major abdominal surgeries based on intraoperative low-dose nutrition: A metabolic perspective. Clin Nutr ESPEN. 2023;58:208-212. 125. Soeda M, Ohka S, Nishizawa D, Iseki M, Yamaguchi K, Arita H, Hanaoka K, Kato J, Ogawa S, Hiranuma A, Hasegawa J, Nakayama K, Ebata Y, Hayashida M, Ichinohe T, Fukuda KI, Ikeda K. Single-Nucleotide Polymorphisms of the PAR2 and IL-17A Genes Are Significantly Associated with Chronic Pain. Int J Mol Sci. 2023;24(24):17627. 126. Hasegawa A, Niimi N, Mitaka C, Hayashida M. Negative pressure pulmonary edema due to upper airway obstruction after general anesthesia in a patient with Parkinson's disease: A case report. Clin Case Rep. 2023;11(6):e7444. 127. Ishikawa S, Shirakawa K, Kuroda Y, Yube Y, Mine S, Hayashida M, Kawagoe I. Persistent bilateral pneumothorax after robotic-assisted inguinal hernia repair: possible relevance to recent esophageal cancer surgery - a case report. JA Clin Rep. 2023;9(1):37. 128. Fukuda M, Sakai H, Koh K, Sakuraba S, Ando N, Hayashida M, Kawagoe I. Unusual severe hypoxemia due to unilateral pulmonary edema after conventional cardiopulmonary bypass salvaged by veno-venous extracorporeal membrane oxygenation: a case report. JA Clin Rep. 2023;9(1):65. 129. Imai E, Fukuda M, Kochiyama T, Yamaguchi A, Sugasawa Y, Hayashida M, Kawagoe I. Successful one-lung ventilation in a patient after laryngectomy by inserting a long spiral single-lumen tube into the left main bronchus: a case report. AME Case Rep. 2023:8:16. 130. Ishikawa S, Hayashida M, Satoh D, Mine S, Kawagoe I. Persistent pneumothorax after laparoscopic appendectomy in a patient who had undergone radical esophagectomy 5 years before: possible relationship with vulnerability of the hiatus after esophagectomy: a case report. J Surg Case Rep. 2024;2024(5):rjae308.

研究テーマ

麻酔科学一般、心臓血管麻酔一般、オピオイドの薬理、神経障害性疼痛の薬物治療など

研究業績（論文）

1. Umeda M, Hara T, Hayashida M, Niijima T. Role of hydroxyl radical in neutrophil-mediated cytotoxicity. Cell Mol Biol. 1985;31(3):229-33.

2. Du HL, Hayashida M, Hanaoka K．Intraperitoneum insufflation of carbon dioxide increases epidural pressure in laparoscopic cholecystectomy．J　Anesth. 1995;9(4):357-9.

3. Du HL, Hayashida M, Suwa K, Yamada Y, Hanaoka K.
Pancuronium increases pulmonary arterial pressure in lung injury. Br J Anaesth. 1996;77(4):526-9.

4. Orii R. Sugawara Y, Hayashida M, Yamada Y, Kubota K, Takayama T, Harihara Y, Makuuchi M, Hanaoka K. Peri-operative blood lactate levels in recipients of living-related liver transplantation. Transplantation. 2000;69(10):2124-7.

5. Orii R，Sugawara Y, Hayashida M, Yamada Y, Chang K, Takayama T, Makuuchi M，Hanaoka K. Effects of amrinone on ischemia-reperfusion injury in cirrhotic patients undergoing hepatectomy: a comparative study with prostaglandin E1. Br J Anaesth. 2000;85(3):389-95.

6. Kato M, Sugawara Y, Orii R, Hayashida M, Kaneko J, Takayama T, Hanaoka K, Makuuchi M, Lactate levels in cirrhotic patients undergoing liver resection. Hepatogastroenterology. 2001;48(40):1106-9.

7. Orii R，Sugawara Y, Hayashida M, Uchida K, Yamada Y, Takayama T, Makuuchi M, Hanaoka K, Lactate is correlated with indocyanine green elimination rate in liver resection for cirrhotic patients. Anesth Analg. 2001;92(4):1064-70.

8. Tomioka T, Sawamura S, Meno A, Hayashida M, Arita H, Hanaoka K. Is the current perception threshold test affected by circadian changes?-A study of healthy volunteers. The Pain Clinic. 2002; 13 (3): 213-215.

9. Hayashida M, Chinzei M, Fujiwara H, Komatsu K, Usui H, Uchida K, Tomioka T, Hanaoka K. Bispectral Index as an indicator of cerebral function during surgery using deep hypothermia and circulatory arrest. Cardiovascular Anesthesia. 2002; 6(1): 9-12,

10. Hayashida M, Chinzei Usui H, M, Komatsu K, Fujiwara H, Yamamoto H, Orii R, Hanaoka K. Frequent occurrence of cerebral ischemic events during pediatric cardiac surgery detected with the Bispectral Index. Cardiovascular Anesthesia. 2002; 6(1): 15-19.

11. Kin N, Hayashida M, Chang K, Uchida K, Hanaoka K. External manual compression of the abdominal aorta to control hemorrhage from a ruptured aneurysm. J Anesth. 2002;16(2):164-6.

12. Hayashida M, Chinzei M, Komatsu K, Yamamoto H, Tamai H, Orii R, Hanaoka K, Murakami A. Detection of cerebral hypoperfusion with bispectral index during paediatric cardiac surgery. Br J Anaesth. 2003;90(5):694-8.

13. Hayashida M, Fukunaga A, Hanaoka K. An animal model for surgical anesthesia and analgesia: characterization with isoflurane anesthesia and remifentanil analgesia. Anesth Analg. 2003;97(5):1340-1346.

14. Hayashida M, Fukunaga A, Hanaoka K. Detection of acute tolerance to the analgesic and nonanalgesic effects of remifentanil infusion in a rabbit model. Anesth Analg. 2003;97(5):1347-1352.

15. Sekiyama H, Sumida T, Hayashida M, Chinzei M, Ide Y, Arita H, Hanaoka K. Postherpetic neuralgia as a risk factor for classic heat stroke. J Anesth. 2003;17(1):57-8.

16. Tomioka T, Hayashida M, Hanaoka K. Pressure alopecia in living donors for liver transplantation. Can J Anaesth. 2004;51(2):186-7.

17. Hanaoka K, Arita H, Hayashida M, Yajima C, Lee SC. Pain control in Asia: Foreword of the round table discussion of pain control. Geriatr Gerontol Int. 2004;4(S1):S237-8.

18. Arita H, Hayashida M, Hanaoka K. Pain control for elderly patients in Japan. Geriatr Gerontol Int. 2004;4(S1):S239-41.

19. Hayashida M, Sato K, Fukunaga A, Fukuda K, Sekiyama H, Sawamura S, Arita H, Hanaoka K. Intravenous infusion of adenosine 5’-triphosphate alleviated a disabling postherpetic neuralgia. J Anesth. 2004;18(1):36-8.

20. Chinzei M, Sawamura S, Hayashida M, Kitamura T, Tamai H, Hanaoka K. The change in Bispectral Index during epileptiform electrical activity under sevoflurane anesthesia in a patient with epilepsy. Anesth Analg. 2004;98(6):1734-1736.

21. Hayashida M, Kin N, Tomioka T, Orii R, Sekiyama H, Usui H, Chinzei M, Hanaoka K. Cerebral ischaemia during cardiac surgery in children detected by combined monitoring of BIS and near-infrared spectroscopy. Brit J Anaesth. 2004;92(5):662-9.

22. Hayashida M, Fukunaga A, Fukuda K, Yamazaki SY, Arita H, Hanaoka K. A rabbit model for evaluation of surgical anesthesia and analgesia: characterization and validation with isoflurane anesthesia and fentanyl analgesia. J Anesth. 2004;18(4):282-91.

23. Hayashida M, Fukuda K, Fukunaga A, Meno A, Sato K, Tarui K, Arita H, Kaneko Y, Hanaoka K. Analgesic effect of intravenous ATP on postherpetic neuralgia in comparison with responses to intravenous ketamine and lidocaine. J Anesth. 2005;19(1):31-5.

24. Bougaki M, Hayashida M, Kin N, Tomioka T, Chinzei M, Hanaoka K. Bispectral Index monitoring during pediatric cardiac surgery: effects of anesthetic doses, hypothermic cardiopulmonary bypass, and age. Cardiovascular Anesthesia. 2005;9(1); 3-9.

25. Hayashida M, Fukuda K, Fukunaga A. Clinical application of adenosine and ATP for pain control. J Anesth. 2005;19(3):225-35.

26. Ikeda K, Ide S, Han W, Hayashida M, Uhl GR, Sora I. How individual sensitivity to opioids can be predicted by gene analyses. Trends Pharmacol Sci. 2005;26(6):311-7.

27. Xu H, Arita H, Hayashida M, Zhang L, Sekiyama H, Hanaoka K. Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats. J Ethnopharmacol. 2006;103(3):392-7.

28. Shu H, Arita H, Hayashida M, Sekiyama H, Hanaoka K. Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine. J Ethnopharmacol. 2006;103(3):398-405.

29. Shu H, Arita H, Hayashida M, Chiba S, Sekiyama H, Hanaoka K. Inhibition of morphine tolerance by processed Aconiti tuber is mediated through activation of kappa opioid receptors. J Ethnopharmacol. 2006;106(2):263-71.

30. Li C, Sekiyama H, Hayashida M, Sumida T, Arita H, Hanaoka K. Effect of repeated topical application of clonidine cream in a rat model of postoperative pain. PAIN RESEARCH. 2006;21(1):25-32.

31. Hayashida M, Fukunaga A, Fukuda K, Sakurai S, Mamiya H, Ichinohe T, Kaneko Y, Hanaoka K. The characteristics of intravenous adenosine-induced antinoception in a rabbit model of acute nociceptive pain: a comparative study with remifentanil. Anesth Analg. 2006;103(4):1004-10.

32. Mizuno J, Akune T, Tsuda T, Fukui Y, Otsuji M, Kin N, Saito Y, Orii R, Hayashida M, Arita H, Hanaoka K: Time course of systolic and diastolic blood pressure decreases during the preintubation period of anesthesia induction: Modelling with a logistic function. J Clin Anesth. 2007;19(7):497-505.

33. Li C, Sekiyama H, Hayashida M, Takeda K, Sumida T, Sawamura S, Yamada Y, Arita H, Hanaoka K. Effects of topical application of clonidine cream on pain behaviors and spinal Fos protein expression in rat models of neuropathic pain, postoperative pain, and inflammatory pain. Anesthesiology. 2007;107(3):486-94.

34. Hayashida M, Sekiyama H, Orii R, Chinzei M, Ogawa M, Arita H, Hanaoka K, Takamoto S. Effects of deep hypothermic circulatory arrest with retrograde cerebral perfusion on EEG bispectral index and suppression ratio. J Cardiothorac Vasc Anesth . 2007;21(1):61-7.

35. Shu H, Hayashida M, Chiba S, Sekiyama H, Kitamura T, Hanaoka K, Yamada Y, Arita H Inhibitory effect of processed Aconiti tuber on the development of antinociceptive tolerance to morphine: evaluation with a thermal assay. J Ethnopharmacol. 2007;113(3):560-3.

36. Fukuda K, Hayashida M, Fukunaga A, Kasahara M, Koukita Y, Ichinohe T, Kaneko Y. Pain-relieving effects of intravenous ATP in chronic intractable orofacial pain: an open-label study. J Anesth. 2007;21(1):24-30.

37. Ohshima N, Chinzei M, Mizuno K, Hayashida M, Kitamura T, Shibuya H, Hanaoka K. Transient decreases in Bispectral Index without associated changes in the level of consciousness during photic stimulation in an epileptic patient. Brit J Anaesth. 2007;98(1):100-4.

38. Mizuno J, Gauss T, Suzuki M, Hayashida M, Arita H, Hanaoka K. Encephalopathy and rhabdomyolysis induced by iotrolan during epiduroscopy. Can J Anaesth. 2007;54(1):49-53.

39. Hayashida M, Nagashima M, Satoh Y, Katoh R, Tagami M, Ide S, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Komatsu H, Sora I, Fukuda K, Koga H, Hanaoka K, Ikeda K. Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype. Pharmacogenomics. 2008;9(11):1605-16.

40. Shu H, Hayashida M, Arita H, Huang W, Xiao L, Chiba S, Sekiyama H, Hanaoka K. High doses of processed Aconiti tuber inhibit the acute but potentiate the chronic antinociception of morphine. J Ethnopharmacol. 2008;119(2):276-83.

41. Shu H, Hayashida M, Huang W, An K, Chiba S, Hanaoka K, Arita H. The comparison of effects of processed Aconiti tuber, U50488 and MK-801 on the antinociceptive tolerance to morphine. J Ethnopharmacol. 2008;117(1):158-65.

42. Kasai S, Hayashida M, Sora I, Ikeda K. Candidate gene polymorphisms predicting individual sensitivity to opioids. Naunyn Schmiedebergs Arch Pharmacol. 2008;377(4-6):269-81.

43. Oshima N, Chinzei M, Kikuchi E, Hayashida M. Preliminary application of processed electroencephalogram monitoring to differentiate senile dementia from depression. Psychogeriatrics. 2009;9(3):116–20.

44. Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, Nishizawa D, OgaiY, Hasegawa J, Nagashima M, Tagami M, Komatsu H, Sora I, Koga H, Kaneko Y, Ikeda K, Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery. Pain. 2009;147(1-3):194-201.

45. Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K. Association between KCNJ6 (GIRK2) gene　polymorphisms and postoperative analgesic requirements after major abdominal surgery. PLoS One. 2009;4(9):e7060.

46. Ariyama J, Hayashida M, Sugimoto Y, Imanishi H, To-oyma Y, Kitamura A. Spread of spinal anesthesia in patients having perianal surgery in the jackknife position: Effects of baricity of 0.5% bupivacaine and posture during and after induction of spinal anesthesia. J Clin Anesth. 2009;21(6):408-13.

47. Ariyama J, Hayashida M, Shibata K, Sugimoto Y, Imanishi H, O-oi Y, Kitamura A. Risk factors for the development of reversible psychomotor dysfunction following prolonged isoflurane inhalation in general intensive care unit. J Clin Anesth. 2009;21(8):567-73.

48. Handa T, Fukuda K, Hayashida M, Koukita Y, Ichinohe T, Kaneko Y. Effects of intravenous adenosine 5'-triphosphate on intraoperative hemodynamics and postoperative pain in patients undergoing major orofacial surgery: a double-blind placebo-controlled study. J Anesth. 2009;23(3):315-22.

49. Chiba S, Hayashida M, Yoshikawa M, Shu H, Nishiyama T, Yamada Y. Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine. J Anesth. 2009;23(1):99-107.

50. Tsukamoto S, Maruyama K, Nakagawa H, Iwase Y, Kitamura A, Hayashida M. Fatal hyperkalemia due to rapid red cell transfusion in a critically ill patient. J Nippon Med Sch. 2009;76(5):258-64.

51. Imanishi H, Kitamura A, Maruyama K, Ariyama J, Nakagawa H, Nishibe S, Hayashida M, Usuda Y. Suspected recurrent anaphylaxia in different forms during general anesthesia. J Anesth. 2010;24(1):143-5.

52. Ariyama J, Imanishi H, Nakagawa H, Kitamura A, Hayashida M. Epicardial hematoma and myocardial ischemia following application of Starfish stabilizer: an uncommon complication of the device. J Anesth. 2010;24(5):801-2.

53. Azuma K, Maruyama K, Imanishi H, Nakagawa H, Kitamura A, Hayashida M. Difficult management of anticoagulation with argatroban in a patient undergoing on-pump cardiac surgery. J Cardiothorac Vasc Anesth. 2010;24(5):831-3.

54. Maruyama K, Nishikawa Y, Nakagawa H, Ariyama J, Kitamura A, Hayashida M. Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil? J Anesth. 2010;24(2):293-6.

55. Shu H, Arita H, Hayashida M, Zhang L, An K, Huang W, Hanaoka K. Anti-hypersensitivity effects of Shu-jing-huo-xue-tang, a Chinese herbal medicine, in CCI-neuropathic rats. J Ethnopharmacol. 2010;131(2):464-70.

56. Maruyama K, Tsukamoto S, Ohno S, Kobayashi K, Nakagawa H, Kitamura A, Hayashida M. Effect of cardiopulmonary resuscitation on intubation using a Macintosh laryngoscope, the AirWay Scope, and the gum elastic bougie: A manikin study. Resuscitation. 2010;81(8):1014-8.

57. Aoki J, Hayashida M, Tagami M, Nagashima M, Fukuda KI, Nishizawa D, Ogai Y, Kasai S, Ikeda K, Iwahashi K. Association between 5-hydroxytryptamine 2A receptor gene polymorphism and postoperative analgesic requirements after major abdominal surgery. Neurosci Lett. 2010;479(1):40-3.

58. Fukuda K, Hayashida M, Ikeda K, Koukita Y, Ichinohe T, Kaneko Y. Diversity of opioid requirements for postoperative pain control following oral surgery--is it affected by polymorphism of the μ-opioid receptor? Anesth Prog. 2010;57(4):145-9.

59. Nishizawa D, Hayashida M, Nagashima M, Koga H, Ikeda K. Genetic polymorphisms and human sensitivity to opioid analgesics. Methods Mol Biol. 2010:617:395-420.

60. Maruyama K, Nakagawa H, Imanishi H, Kitamura A, Hayashida M. Comparison of postoperative pharyngeal morbidity using the Macintosh laryngoscope or AirWay Scope after mastectomy. J Anesth. 2011;25(5):773-6.

61. Chinzei M, Kitamura T, Oshima N, Hayashida M, Komori C, Kin N, Sekiyama H, Suzuki M, Yamada Y. Simultaneous monitoring of consciousness and hemodynamics during therapeutic total spinal anesthesia. Jpn J Clin Physiol. 2011; 41(6): 209-14.

62. Shu H, Hayashida M, Arita H, Huang W, Zhang H, An K, Wu G, Hanaoka K. Pentazocine-induced antinociception is mediated mainly by μ-opioid receptors and compromised by κ-opioid receptors in mice. J Pharmacol Exp Ther. 2014;349(2):347.

63. Hanaoka K, Hayashida M, Arita H, Ide Y, Tagami M, Nagase M. Drug challenge tests for diagnosis and treatments of intractable chronic pain. ScienceMED. 2011;2(4):279-82.

64. Nakagawa H, Maruyama K, Hayashida M, Kakoi H, Ohki R, Takenouchi K, Kitamura A. Comparison of tracheal intubation using Macintosh and Airtraq laryngoscopes during cardiopulmonary resuscitation with or without cervical immobilization：a manikin study. Anesthesia and Resuscitation. 2012;48(4):93-8.

65. Maruyama K, Mieda T, Nakagawa H, Kitamura A, Hayashida M. The effect of light-emitting diodes on intubation with Vital View plastic laryngoscope blade during a simulated resuscitation. Am J Emerg Med. 2012;30(1):242-4.

66. Sugasawa Y, Hayashida M, Yamaguchi K, Kajiyama Y, Inada E. Usefulness of stroke volume index obtained with the FloTrac/ Vigileo system for the prediction of acute kidney injury after radical esophagectomy. Ann Surg Oncol. 2013;20(12):3992-8.

67. Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K. Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. PLoS One. 2013;8(8):e70694.

68. Kasagi Y, Hayashida M, Sugasawa Y, Kikuchi I, Yamaguchi K, Okutani R, Takeda S, Inada E.　Antiemetic effect of naloxone in combination with dexamethasone and droperidol in patients undergoing laparoscopic gynecological surgery. J Anesth. 2013;27(6):879-84.

69. Mieda T, Hayashida M, Maruyama K, Nakagawa H, Yoshikawa H, Terao K, Imanishi H, Ariyama J, Kitamura A. Pulmonary Gas Embolism as a Potential Cause of Hypoxia Immediately After Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. 2013;27(5):951-4.

70. Sugasawa Y, Hayashida M, Inada E. Discrete subaortic stenosis diagnosed intraoperatively. J Anesth. 2014;28(2):311.

71. Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K. Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl. Mol Pain. 2014:10:75.

72. Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K. Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence. J Pharmacol Sci. 2014;126(3):253-63.

73. Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Aoki Y, Nishi A, Saita N, Koukita Y, Nagashima M, Katoh R, Satoh Y, Tagami M, Higuchi S, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Koga M, Arinami T, Kaneko Y, Hayashida M, Ikeda K.　Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Mol Psychiatry. 2014;19(1):55-62.

74. Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, Nagashima M, Katoh R, Satoh Y, Tagami M, Ujike H, Ozaki N, Inada T, Iwata N, Sora I, Iyo M, Yamada M, Kondo N, Won MJ, Naruse N, Uehara-Aoyama K, Itokawa M, Ohi K, Hashimoto R, Tanisawa K, Arai T, Mori S, Sawabe M, Naka-Mieno M, Yamada Y, Yamada M, Sato N, Muramatsu M, Tanaka M, Irukayama-Tomobe Y, Saito YC, Sakurai T, Hayashida M, Sugimura H, Ikeda K. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Mol Brain. 2015:8:50.

75. Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K. Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements. J Pharmacol Sci. 2015;127(3):391-3.

76. Yoshida K, Nishizawa D, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K. Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. PLoS One. 2015;10(1):e0116885.

77. Mieda T, Nishizawa D, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M. Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. Pharmacogenomics. 2016;17(2):133-45.

78. Kawagoe I, Hayashida M, Suzuki K, Kitamura Y, Oh S, Satoh D, Inada E. Anesthetic management of patients undergoing right lung surgery after left upper lobectomy: selection of tubes for one-lung ventilation (OLV) and oxygenation during OLV. J Cardiothorac Vasc Anesth. 2016;30(4):961-6.

79. Ishibashi C, Hayashida M, Sugasawa Y, Yamaguchi K, Tomita N, Kajiyama Y, Inada E. Effects of dexmedetomidine on hemodynamics and respiration in intubated, spontaneously breathing patients after endoscopic submucosal dissection for cervical esophageal or pharyngeal cancer. J Anesth. 2016;30(4):628-36.

80. Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K. Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery. J Pain. 2016;17(10):1126-1134.

81. Mukaida H, Hayashida M, Matsushita S, Yamamoto M, Nakamura A, Amano A. Brain natriuretic peptide (BNP) may play a major role in risk stratification based on cerebral oxygen saturation by near-infrared spectroscopy in patients undergoing major cardiovascular surgery. PLoS One. 2017;12(7):e0181154.

82. Kawagoe I, Hayashida M, Nozumi Y, Banno T, Hirayama S, Suzuki K, Satoh D, Naito Y, Inada E A Combination of a partial anomalous pulmonary venous connection (PAPVC) and a lung tumor requiring pulmonary resection. J Cardiothorac Vasc Anesth. 2017;31(1):274-278.

83. Kawagoe I, Hayashida M, Satoh D, Suzuki K, Inada E. Ventilation failure after lateral jackknife positioning for robot-assisted lung cancer surgery in a patient after lingula-sparing left upper lobectomy. JA Clin Rep. 2018;4:51.

84. Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda KI, Kitamura A, Hayashida M, Ikeda K. Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy. Pharmacogenomics. 2018;19:113-127.

85. Yamamoto M, Hayashida M, Kakemizu-Watanabe M, Ando N, Mukaida H, Kawagoe I, Yusuke S, Inada E. B-type natriuretic peptide and hemoglobin are two major factors significantly associated with baseline cerebral oxygen saturation measured using the INVOS oximeter in patients undergoing off-pump coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2018;32:187-196.

86. Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda KI, Ikeda K. Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test. Neuropsychopharmacol Rep. 2018;38:86-91.

87. Kawagoe I, Hayashida M, Satoh D, Inada E. Intercostal misplacement of a thoracic epidural catheter discovered during lung cancer surgery: a case report. JA Clin Rep. 2019;5:44.

88. Niimi N, Kataoka K, Hayashida M, Inada E. The dynamic collapse of the trachea during anesthesia for a pediatric patient with a large anterior mediastinal mass: A case report. Clin Case Rep. 2020;8(9):1814-15.

89. Kawagoe I, Satoh D, Mitaka C, Fukuda M, Kochiyama T, Hayashida M. Specific airway management for SVC replacement during giant anterior mediastinal tumor resection. JA Clin Rep. 2020;6(1):70.

90. Mukaida H, Hayashida M, Matsushita S, Endo D, Oishi A, Shimada A, Hata H, Kajimoto K, Yamamoto T, Amano A. Free triiodothyronine (fT3) and B-type natriuretic peptide (BNP) predict in-hospital mortality after valve surgery. Gen Thorac Cardiovasc Surg. 2020;68(6):585-95.

91. Nishizawa D, Iseki M, Arita H, Hanaoka K, Yajima C, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Hayashida M, Ikeda K. Genome-wide association study identifies candidate loci associated with chronic pain and postherpetic neuralgia. Mol Pain. 2021;17:1744806921999924.

92. Inoue R, Nishizawa D, Hasegawa J, Nakayama K, Fukuda K, Ichinohe T, Mieda T, Tsujita M, Nakagawa H, Kitamura A, Sumikura H, Ikeda K, Hayashida M. Effects of rs958804 and rs7858836 single-nucleotide polymorphisms of the ASTN2 gene on pain-related phenotypes in patients who underwent laparoscopic colectomy and mandibular sagittal split ramus osteotomy. Neuropsychopharmacol Rep. 2021;41(1):82-90.

93. Kawagoe I, Hayashida M, Satoh D, Kochiyama T, Fukuda M, Kishii J. Postoperative analgesia in patients undergoing robot-assisted thoracic surgery: a comparison between thoracic epidural analgesia and intercostal nerve block combined with intravenous patient-controlled analgesia. Ann Palliat Med. 2021;10:1985-93.

94. Fukuda M, Kawagoe I, Kochiyama T, Ando N, Kudoh O, Satoh D, Hayashida M. Well leg compartment syndrome following robot-assisted radical cystectomy in the lithotomy position: a case report. JA Clin Rep. 2021;7:13.

95. Kuroda Y, Nonaka M, Kamikubo Y, Ogawa H, Murayama T, Kurebayashi N, Sakairi H, Miyano K, Komatsu A, Dodo T, Nakano-Ito K, Yamaguchi K, Sakurai T, Iseki M, Hayashida M, Uezono Y. Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors. Biomed Pharmacother. 2021;141:111800.

96. Kawagoe I, Hayashida M, Satoh D, Kudoh O, Fukuda M, Kochiyama T, Kishii J, Mitaka C. Unique strategy using a standard double lumen tube during one lung ventilation for successful intraoperative airway management in patients with a giant bulla on the ventilated side: case series. J Anesth. 2021;35(5):761-6.

97. Yamaguchi A, Kawagoe1 I, Inoue S, Kochiyama T, Fukuda M, Saito M, Hayashida M. Propofol decreases CD8+ T cells and sevoflurane increases regulatory T cells after lung cancer resection: a randomized controlled trial. J Thorac Dis 2021;13:5430-8.

98. Kadokura Y, Hayashida M, Kakemizu-Watanabe M, Yamamoto M, Endo D, Oishi A, Nakanishi K, Hata H. Cerebral oxygen saturation (rSO 2) during cardiopulmonary bypass (CPB) measured using the INVOS oximeter closely correlates with baseline rSO2. J Artif Organs. 2021;24(4):433-41.

99. Mitaka C, Kawagoe I, Satoh D, Hayashida M. Effect of recombinant human soluble thrombomodulin on coagulation-related variables in patients with sepsis-induced disseminated intravascular coagulation: a retrospective observational study. Clin Appl Thromb Hemost. 2021;27:10760296211050356.

100. Ohka S, Yamada S, Nishizawa D, Fukui Y, Arita H, Hanaoka K, Iseki M, Kato J, Ogawa S, Hiranuma A, Kasai S, Hasegawa J, Hayashida M, Fukushi S, Saijo M, Ikeda AK. Heparan sulfate 3- O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus-mediated fusogenic activity. Mol Pain. 2021;17:17448069211052171.

101. Karasawa Y, Miyano K, Fujii H, Mizuguchi T, Kuroda Y, Nonaka M, Komatsu A, Ohshima K, Yamaguchi M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M. In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways. Molecules. 2021;26(19):6079.

102. Nakamura K, Sugita A, Sekiya S, Kitamura A, Mitsuhata H, Yamaguchi K, Hayashida M. Paths of thoracic epidural catheters in children undergoing the Nuss procedure for pectus excavatum repair. J Anesth. 2022;36(3):335-340.

103. Furuta Y, Nakamura Y, Tokida M, Ichikawa K, Okada H, Hayashida M, Okubo M, Ohsaka A. Implementation of an electronic identification system in the setting of perioperative autologous cell salvage transfusion: Experience at a university hospital. Transfus Apher Sci. 2022;61(1):103281.

104. Kasai S, Nishizawa D, Hasegawa J, Fukuda KI, Ichinohe T, Nagashima M, Hayashida M, Ikeda K. Short Tandem Repeat Variation in the CNR1 Gene Associated With Analgesic Requirements of Opioids in Postoperative Pain Management. Front Genet. 2022;13:815089.

105. Nishizawa D, Nagashima M, Kasai S, Hasegawa J, Nakayama K, Ebata Y, Fukuda KI, Ichinohe T, Hayashida M, Ikeda K. Associations between the C3orf20 rs12496846 Polymorphism and Both Postoperative Analgesia after Orthognathic and Abdominal Surgeries and C3orf20 Gene Expression in the Brain. Pharmaceutics. 2022;14(4):727.

106. Inada M, Kawagoe I, Kudoh O, Satoh D, Mitaka C, Hayashida M. Dilutional acidosis during whole lung lavage under general anesthesia due to excessive absorption of normal saline. JA Clin Rep. 2022;8(1):30.

107. Kawagoe I, Hayashida M, Satoh D, Mitaka C. Comparison of desflurane and propofol in the speed and the quality of emergence from anesthesia in patients undergoing lung cancer surgery-a prospective, randomized study. Transl Cancer Res. 2022;11(4):736-44.

108. Kageshima Y, Inada E, Yamaguchi K, Hayashida M. Comparison Between Effects of Amenamevir and Famciclovir on Intensities of Acute Pain and the Incidence of Postherpetic Neuralgia in Adult Patients with Herpes Zoster. Juntendo Medical Journal. 2022;68(2):120-30.

109. Komatsu A, Miyano K, Nakayama D, Mizobuchi Y, Uezono E, Ohshima K, Karasawa Y, Kuroda Y, Nonaka M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M. Novel Opioid Analgesics for the Development of Transdermal Opioid Patches That Possess Morphine-Like Pharmacological Profiles Rather Than Fentanyl: Possible Opioid Switching Alternatives Among Patch Formula. Anesth Analg. 2022;134(5):1082-93.

110. Takeuchi K, Hayashida M, Kudoh O, Niimi N, Kataoka K, Kakemizu-Watanabe M, Yamamoto M, Hara A, Kawagoe I, Yamaguchi K. Continuing versus withholding angiotensin receptor blocker (ARB)/calcium channel blocker (CCB) combination tablets during perioperative periods in patients undergoing minor surgery: a single-blinded randomized controlled trial. J Anesth. 2022;36(3):374-82.

111. Yamazaki S, Yamaguchi K, Someya A, Nagaoka I, Hayashida M. Anti-Inflammatory Action of Dexmedetomidine on Human Microglial Cells. Int J Mol Sci. 2022;23(17):10096.

112. Yamaguchi M, Miyano K, Hirayama S, Karasawa Y, Ohshima K, Uezono E, Komatsu A, Nonaka M, Fujii H, Yamaguchi K, Iseki M, Hayashida M, Uezono Y. Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways. Molecules. 2022;27(20):7065.

113. Umeno Y, Ishikawa S, Kudoh O, Hayashida M. Effects of the Multidisciplinary Preoperative Clinic on the Incidence of Elective Surgery Cancellation. J Med Syst. 2022;46(12):95.

114. Miyake Y, Fujiwara K, Kataoka K, Ochi T, Seo S, Koga H, Lane GJ, Nishimura K, Hayashida M, Yamataka A. Retroperitoneoscopic Surgery in Children Does Not Cause Pathological Desaturation in Cerebral/Renal Oxygenation on Near-Infrared Spectroscopy Compared with Laparoscopic and Thoracoscopic Surgery. J Laparoendosc Adv Surg Tech A. 2022;32(12):1260-4.

115. Kudoh O, Hayashida M. Historical Changes in Anesthesia Practice for Laparoscopic Gynecological Surgery at Juntendo University Hospital – A Retrospective Observational Study Focusing on Factors Affecting the Incidence of Postoperative Nausea and Vomiting. Juntendo Medical Journal. 2022;68(6):582-9.

116. Aoki Y, Nishizawa D, Ohka S, Kasai S, Arita H, Hanaoka K, Yajima C, Iseki M, Kato J, Setsuro Ogawa S, Hiranuma A, Hasegawa J, Nakayama K, Ebata Y, Ichinohe T, Hayashida M, Fukuda K-I, Kazutaka Ikeda K. Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain. Int J Mol Sci. 2023 Jan 5;24(2):1028.

117. Kusano Y, Kawagoe I, Yamaguchi A, Kishii J, Morita Y, Fukuda M, Kochiyama T, Hayashida M. Postoperative analgesia following robot-assisted thoracic surgery for mediastinal disease: retrospective comparative study of general anesthesia alone, combined with epidural analgesia, and with ultrasound-guided thoracic paraspinal block. Ann Transl Med. 2023;11(5):206.

118. Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai, S, Hasegawa J, Nakayama K, Ebata Y, Kitamura A, Shimizu H, Takashima T, Masakazu Hayashida M, Ikeda K. Genome-Wide Association Study Identifies Genetic Polymorphisms Associated with Estimated Minimum Effective Concentration of Fentanyl in Patients Undergoing Laparoscopic-Assisted Colectomy. Int J Mol Sci. 2023;24(9):8421.

119. Uezono E, Mizobuchi Y, Miyano K, Ohbuchi K, Murata H, Komatsu A, Manabe S, Nonaka M, Hirokawa T, Yamaguchi K, Iseki M, Uezono Y, Hayashida M, Kawagoe I. Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses. Int J Mol Sci. 2023;24(9):8369.

120. Ikeda M, Hayashida M, Kadokura Y, Kakemizu-Watanabe M, Yamamoto M, Miyazaki S, Gong C, Ishikawa S. Associations among preoperative transthoracic echocardiography variables and cerebral near-infrared spectroscopy values at baseline before anesthesia in patients undergoing cardiac surgery: a retrospective observational study. Heart Vessels. 2023;38(6):839-48.

121. Nishizawa D, Morino R, Inoue R, Ohka S, Kasai S, Hasegawa J, Ebata Y, Nakayama K, Sumikura H, Hayashida M, Yokota M, Ikeda K. Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting. Cancers (Basel). 2023 26;15(19):4729.

122. Umeno Y, Ishikawa S, Kudoh O, Nojiri S, Deshipande G, Inada E, Hayashida M. Introduction of a Multidisciplinary Preoperative Clinic at Juntendo University Hospital - A Retrospective Observational Study Focusing on Effects of Preoperative Interventions on Clinical Outcomes. Juntendo Medical Journal. 2023;69(5):378-87.

123. Mitaka C, Teranishi K, Wakita M, Misawa S, Nojiri S, Satoh D, Hayashida M. Incidences of and risk factors for clinical and subclinical contrast-associated acute kidney injury in patients who underwent neuroendovascular surgery. Neuroradiol J. 2023;36(5):601-609.

124. Satoh D, Takeuchi K, Kawagoe I, Kisii J, Kudoh O, Hayashida M. Prognosis for major abdominal surgeries based on intraoperative low-dose nutrition: A metabolic perspective. Clin Nutr ESPEN. 2023;58:208-212.

125. Soeda M, Ohka S, Nishizawa D, Iseki M, Yamaguchi K, Arita H, Hanaoka K, Kato J, Ogawa S, Hiranuma A, Hasegawa J, Nakayama K, Ebata Y, Hayashida M, Ichinohe T, Fukuda KI, Ikeda K. Single-Nucleotide Polymorphisms of the PAR2 and IL-17A Genes Are Significantly Associated with Chronic Pain. Int J Mol Sci. 2023;24(24):17627.

126. Hasegawa A, Niimi N, Mitaka C, Hayashida M. Negative pressure pulmonary edema due to upper airway obstruction after general anesthesia in a patient with Parkinson's disease: A case report. Clin Case Rep. 2023;11(6):e7444.

127. Ishikawa S, Shirakawa K, Kuroda Y, Yube Y, Mine S, Hayashida M, Kawagoe I. Persistent bilateral pneumothorax after robotic-assisted inguinal hernia repair: possible relevance to recent esophageal cancer surgery - a case report. JA Clin Rep. 2023;9(1):37.

128. Fukuda M, Sakai H, Koh K, Sakuraba S, Ando N, Hayashida M, Kawagoe I. Unusual severe hypoxemia due to unilateral pulmonary edema after conventional cardiopulmonary bypass salvaged by veno-venous extracorporeal membrane oxygenation: a case report. JA Clin Rep. 2023;9(1):65.

129. Imai E, Fukuda M, Kochiyama T, Yamaguchi A, Sugasawa Y, Hayashida M, Kawagoe I. Successful one-lung ventilation in a patient after laryngectomy by inserting a long spiral single-lumen tube into the left main bronchus: a case report. AME Case Rep. 2023:8:16.

130. Ishikawa S, Hayashida M, Satoh D, Mine S, Kawagoe I. Persistent pneumothorax after laparoscopic appendectomy in a patient who had undergone radical esophagectomy 5 years before: possible relationship with vulnerability of the hiatus after esophagectomy: a case report. J Surg Case Rep. 2024;2024(5):rjae308.

研究者

教育活動

【学校法人順天堂】研究者情報データベース

研究業績詳細

林田 眞和（ハヤシダ マサカズ）

林田眞和（ハヤシダマサカズ）