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研究業績詳細

水野 博司(ミズノ ヒロシ)

研究テーマ 脂肪組織由来幹細胞や徐放型増殖因子による再生医学、創傷治癒学研究、下肢難治性創傷に対する下肢救済医学
研究業績(論文) Sano K, Suehara Y, Kubota D, Takahashi R, Ichikawa Y, Tobita M and Mizuno H
Subtotal second toe transfer for finger reconstruction after malignant fibroblastic tumor resection
J Hand Microsurg DOI https://doi.org/ 10.1055/s-0043-1762897. ISSN 0974-3227, 2023

Sano K, Kimura K, Ichikawa Y and Mizuno H
Blind curettage technique for treatment of mucous cyst associated with Heberden nodes: description of operative technique
J Hand Microsurg DOI https://doi.org/ 10.1055/s-0043-1761228. ISSN 0974-3227, 2023

Ichikawa Y, Tobita M, Takahashi R, Ito T, Senda D, Tanaka R, Mizuno H and Sano K
Learning curve and ergonomics associated with 3D-monitor-assisted microsurgery using a digital microscope
J Plast Reconstr Surg January 27; doi: dx.doi.org/10.53045/jprs.2021-0026, 2023

Tanaka R, Fujimura S, Kado M, Arita K, Hirano-Ito R, Mita T, Watada H, Kato Y, Miyauchi K and Mizuno H
Phase I/IIa feasibility trial of autologous quality-and quantity-cultured peripheral blood mononuclear cell therapy for non-healing extremity ulcers
Stem Cells Transl Med 11: 146-158, 2022

Tobita M, Masubuchi Y, Ogata Y, Mitani A, Kikuchi T, Toriumi T, Raudales JLM, Mizuno H, Suzuki Y, Wakana K, Yoneda H, Kamijo R, Kino-oka M, Morio T, Okada K, Murakami S and Honda M
Study protocol for periodontal tissue regeneration with a mixture of autologous adipose-derived stem cells and platelet rich plasma: A multicenter, randomized, open-
label clinical trial
Regener Ther 21: 436-441, 2022

Jiang S, Ito-Hirano R, Nishikai-Shen T, Fujimura S, Mizuno H and Tanaka R
Effect of MNCQQ cells on migration of human dermal fibroblast in diabetic condition
Biomedicines 10, 2544 doi.org/10.3390/biomedicines10102544, 2022

Matsui C, Escandon JM, Mohammad A, Tanaka T, Sasaki M, Myo MM, Yu L, Thein YYC and Mizuno H
Dental silicone-based surgical guide to harvest the chimeric scapular flap: preventing iatrogenic vascular injury
Plast Reconstr Surg Global Open 10: e4337, 2022

Ichikawa Y, Hayashi A, Tobita M, Sano K and Mizuno H
Initial experience of 4K-three-dimensional digital microscope for lymphaticovenular anastomosis
Plast Reconstr Surg 150: 935e-936e, 2022

Matsui C, Lao WW, Tanaka T, Tsuji N, Matsui Y, Orgun D, Sugawara Y and Mizuno H
Real-time assessment of free flap capillary circulation using video-capillaroscopy
Plast Reconstr Surg 150: 407-413, 2022

Matsui C, Mizuno H and Roche N
Use of dental impression silicone to facilitate simple surgical guides in mandibular reconstruction
J Craniofas Surg 33: e28-e30, 2022

Ko KC and Mizuno H
Functional and aesthetic double eyelid surgery: challenges and the first clinical outcome study in Myanmar
Juntendo Medical Journal 67: 451-462, 2021

Faruk M, Josh F, Soekamto TH, Adriani JR, Jonatan B and Mizuno H
The combination of stromal vascular fraction cells and platelet-rich plasma reduces malondialdehyde and nitric oxide levels in deep dermal burn injury
J Inflamm Res 14: 3049-3061, 2021

Tanaka R, Ito-Hirano R, Fujimura S, Arita K, Hgiwara H, Mita T, Itoh M, Kawaji H, Ogawa T, Watada H, Masuda H, Asahara T and Mizuno H
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing
Stem Cells Translational Medicine 10: 895-909, 2021

Morimura N, Mizobata Y, Sugita M, Takeda S, Kiyozumi T, Shoko T, Inoue Y, Otomo Y, Sakurai A, Koido Y, Tanabe S, Okumura T, Yamasawa F, Tanaka H, Kinoshi T, Kaku K, Matsuda K, Kitamura N, Hayakawa T, Kuroda Y, Kuroki Y, Sasaki J, Oda J, Inokuchi M, Kakuta T, Arai S, Sato N, Matsuura H, Nozawa M, Osamura T, Yamashita K, Okudera H, Kawana A, Koshinaga T, Hirano S, Sugawara E, Kamata M, Tajiri Y, Kohno M, Suzuki M, Nakase H, Suehiro E, Yamase H, Otake H, Morisaki H, Ozawa A, Takahashi S, Otsuka K, Harikae K, Kishi K, Mizuno H, akajima H, Ueta H Nagayama M, Kikuchi M, Yokota H Shimazu T, Yukioka T and The Joint Committee of the Academic Consortium
on Emergency Medical Services, Disaster Medical Response Plan during the Tokyo Olympic and Paralympic Games in 2020 (AC2020)
Medicine at mass gatherings: current progress of preparedness of emergency medical services and disaster medical response during 2020 Tokyo Olympic and Paralympic games from the perspective of academic consortium (AC2020)
Acute Medicine & Surgery 8: e626, 2021

Geerom M, Fujimura S, Aiba E, Orgun D, Arita K, Kitamura R, Senda D, Mizuno H, Hamdi M and Tanaka R
Quality and quantity-cultured human mononuclear cells improve the human fat graft vascularization and survival in an in vivo murine experimental model
Plast Reconstr Surg 147: 373-385, 2021

水野博司、山下理絵、宮田成章、林 寛子
特定細胞加工物および細胞増殖因子を用いた注入療法の現状調査
日本美容外科学会会報 42: 19-26, 2020

Orgun D, Yoshizawa H, Shimizu A, Horiguchi M, Mochizuki M, Kamimori T, Aiba-Kojima E, Mizuno H and Hayashi A
Oncoplastic lower eyelid reconstruction – A 10-year retrospective analysis
J Craniofas Surg 30: 2396-2400, 2019

Ichikawa Y, Senda D, Shingyochi Y and Mizuno H
Potential advantages of using three-dimensional exoscope for microvascular anastomosis in free flap transfer
Plast Reconstr Surg 144: 726e-727e, 2019

Geeroms M, Hamdi M, Hirano R, Hagiwara H, Fujimura S, Mizuno H and Tanaka R
Quality and quantity cultured murine endothelial progenitor cells increase vascularization and decrease fibrosis in the fat graft
Plast Reconstr Surg 143: 744e, 2019

Senda D, Orgun D, Shimizu A, Shimoji K, Miyajima M, Arai H, Mizuno H and Komuro Y
Quantitative analysis of change in intracranial volume after posterior cranial vault distraction and frontal orbital advancement/remodeling
J Craniofas Surg 30: 23-27, 2019

Shigeta R, Orgun D, Mizuno H and Hayashi A
Mammary analogue secretory carcinoma (MASC) arising in the parotid gland of child
Plast Reconstr Surg Glob Open 6 (12): e2059, 2018

Hagiwara H, Higashibata A, Ogawa S, Kanazawa S, Mizuno H and Tanaka R
Effectiveness of endothelial progenitor cell culture under microgravity for improved angiogenic potential
Sci Rep 8 (1): 14239, 2018

Kado M, Tanaka R, Arita K, Okada K, Hirano R, Fujimura S and Mizuno H
Human peripheral blood mononuclear cells enriched in endothelial progenitor cells via quality and quantity controlled culture accelerate vascularization and wound healing in a porcine wound model
Cell Transplant 27: 1068-1079, 2018

Ohtake T, Kobayashi S, Mochida Y, Ishioka K, Moriya H, Hidaka S, Matsuura R, Sumida M, Katagiri D, Noiri E, Slavin S, Mizuno H and Tanaka R
Human peripheral blood mononuclear cells incubated in vasculogenic conditioning medium dramatically improve ischemia/reperfusion acute kidney injury in mice
Cell Transplant 27: 520–530, 2018

Tanaka R, Masuda H, Fujimura S, Ito-Hirano R, Arita K, Kakinuma Y, Hagiwara H, Kado M, Hayashi A, Mita T, Ogawa T, Watada H, Mizuno H, Sawada N and Asahara T
Quality-quantity control culture enhances vasculogenesis and wound healing efficacy of human diabetic peripheral blood CD 34+ cells
Stem Cells Transl Med 7: 428-438, 2018

Tajima S, Tobita M and Mizuno H
Current status of bone regeneration using adipose-derived stem cells
Histol Histopathol 33: 619-627, 2018

Mifuji K, Ishikawa M, Kamei N, Tanaka R, Arita K, Mizuno H, Asahara T, Adachi N and Ochi M
Angiogenic conditioning of peripheral blood mononuclear cells promotes fracture healing
Bone Joint Res 6: 489-498, 2017

Nishikai-Yan Shen T, Kanazawa S, Kado M, Okada K, Luo L, Hayashi A, Mizuno H and Tanaka R
Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice
PLOS ONE 23; 12: e0178232, 2017

Hayashi A, Mochizuki M, Kamimori T, Horiguchi M, Tanaka R and Mizuno H
Application of Kuhnt-Szymanowski procedure to lower eyelid margin defect after tumor resection
Plast Reconstr Surg Global Open 5: e1230, 2017

Shingyochi Y, Kanazawa S, Tajima S, Tanaka R, Mizuno H and Tobita M
A low-level carbon dioxide laser promotes fibroblast proliferation and migration through activation of Akt, ERK, and JNK
PLOS ONE 12: e168937, 2017

Senda D, Andou E, OrgunD, Horiguchi M, Matsuda A, Arakawa A, Mizuno H and Hayashi A
The rapid development of squamous cell carcinoma on the nasal dursum of a patient receiving immunosuppressive therapy
J Craniofas Surg 28: e277-279, 2017

Kado M, Shimizu A, Matsumura T, Mochizuki M, Mizuno H and Hayashi A
Successful treatment of infantile hemangioma with propranolol in low-birth-weight infants
J Craniofac Surg 28: 789-793, 2017

Orgun D, Horiguchi M, Hayashi A, Shimoji K, Arai H and Mizuno H
Conservative treatment of large aplasia cutis congenital of the scalp with bone defect with basic fibroblast growth factor application: A case report
J Craniofac Surg 28: e154-158, 2017

Luo L, Tanaka R, Kanazawa S, Lu F, Yokomizo T and Mizuno H
A synthetic BLT2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes
J Diabetes Complications 31: 13-20, 2017

Orgun D and Mizuno H
Multipotency and secretome: the mechanisms behind the regenerative potential of adipose-derived stem cells
Plast Aesthet Res 4: 32-40, 2017

Horiguchi M, Miyata N and Mizuno H
A preclinical study testing “Focused Multiple Laser Beams”, a new concept of irradiation with the 1064nm Nd:YAG laser for skin rejuvenation
J Cosmet and Laser Ther DOI: 10.1080/14764172.2016.1256484, 2017

Natori Y, Yoshizawa H, Senda D, Mizuno H and Hayashi A
The fluorescent intensity from the transgenic Thy-1-YFP 16 mouse correlates with amount of regenerated axons
Plast Reconstr Surg Glob Open 4(6):e758, 2016

Yoshizawa H, Senda D, Natori Y, Tanaka R, Mizuno H and Hayashi A
End-to-side neurorrhaphy as Schwann cells provider to acellular nerve allograft and its suitable application
PLOS ONE 11: e0167507, 2016 

Horikoshi-Ishihara H, Tobita M, Tajima S, Tanaka R, Oshita T, Tabata Y and Mizuno H
Co-administration of adipose-derived stem cells and control-released basic fibroblast growth factor facilitates angiogenesis in a murine ischemic hind limb model
J Vasc Surg 64: 1825-1834, 2016

Oshita T, Tobita M, Tajima S and Mizuno H
Adipose-derived stem cells improve collagenase-induced tendinopathy in a rat model
Am J Sports Med 44: 1983-1989, 2016

Hayashi A, Yoshizawa H, Natori Y, Senda D, Tanaka R and Mizuno H
Levator lengthening technique using cartilage or fascia graft for paralytic lagophthalmos in facial paralysis
J Plast Reconstr Aesthet Surg 69: 679-686, 2016

Sukmawati D, Tanaka R, Fujimura S, Jitsukawa S, Ito-Hirano R, Hayashi A, Itoh S, Mizuno H, and Daida H
The role of notch signaling in oxidative stress tolerance cells dysfunction
J Diabetes Complications 30: 12-20, 2016

Hayashi A, Natori Y, Komoto M, Matsumura T, Horiguchi M, Yoshizawa H, Iwanuma Y, Tsurumaru M, Kajiyama Y and Mizuno H
Microvascular reconstruction of free jejunal graft in larynx-preserving esophagectomy for cervical esophageal carcinoma
Plast Reconstr Surg Global Open 4: e632, 2016

Ferraro GA, Mizuno H and Pallua N
Editorial - Adipose stem cells: From bench to bedside
Stem Cells International ID 6484038, 2016

Hayashi A, Mochizuki M, Suda S, Natori Y, Andou E, Yoshizawa H, Senda D, Tanaka R and Mizuno H
Effectiveness of platysma muscle flap in preventing Frey syndrome and depressive deformities after parotidectomy
J Plast Reconstr Aesthet Surg 69: 663-672, 2016

Hayashi A, Yoshizawa H, Natori Y, Suda S, Mochizuki M, Tsukiyama Y, Tanaka R and Mizuno H
Assessment of T-shaped double fascia graft for lower lip deformity from facial paralysis: A questionnaire survey
J Plast Reconstr Aesthet Surg 69: 427-435, 2016

Huang C, Orbay H, Tobita M, Miyamoto M, Tabata Y, Hyakusoku H and Mizuno H
Pro-apoptotic effect of control-released basic fibroblast growth factor on skin wound healing in a diabetic mouse model
Wound Repair Regen 24: 65-74, 2016

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