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野澤和久（ノザワカズヒサ）

研究テーマ	膠原病リウマチ内科学
研究業績（論文）	# Nozawa K, Doe K, Uomori K, Sekigawa I, Takasaki Y, Yamaji K, Tamura N. Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus erythematosus. Autoimmunity. 2017 May 27:1-6. doi: 10.1080/08916934.2017.1329422. [Epub ahead of print] PubMed PMID: 28553742. # Uomori K, Nozawa K（corresponding author）, Ikeda K, Doe K, Yamada Y, Yamaguchi A, Fujishiro M, Kawasaki M, Morimoto S, Takamori K, Sekigawa I, Chan EK, Takasaki Y. A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren's syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14. Autoimmunity. 2016 Jun 21:1-10. [Epub ahead of print] PubMed PMID: 27328271. #　Matsuki-Muramoto Y, Nozawa K（corresponding author）, Uomori K, Sekigawa I, Takasaki Y. Bortezomib treatment prevents glomerulosclerosis associated with lupus nephritis in a murine model through suppressive effects on the immune and renin-angiotensin systems. Mod Rheumatol. 2016 May 11:1-10. [Epub ahead of print] PubMed PMID: 27166507. # Yamada Y, Nozawa K（corresponding author）, Nakano S, Mitsuo Y, Hiruma K, Doe K, Sekigawa I, Yamanaka K, Takasaki Y. Antibodies to microtubule-associated protein-2 in the cerebrospinal fluid are a useful diagnostic biomarker for neuropsychiatric systemic lupus erythematosus. Mod Rheumatol. 2016 Feb 16:1-7. [Epub ahead of print] PubMed PMID: 26667376. #Doe K, Nozawa K, Hirai T, Tsushima H, Hayashi E, Hiruma K, Ando S, Nakano S, Kon T, Amano H, Yamaji K, Tamura N, Takasaki Y. Second-to-fourth Digit Ratio in Systemic Lupus Erythematosus. J Rheumatol. 2015 Mar 1. pii: jrheum.140974. [Epub ahead of print] PubMed PMID: 25729029. #Nozawa K（corresponding author）, Fujishiro M, Takasaki Y, Sekigawa I. Inhibition of rheumatoid　arthritis by blocking connective tissue growth factor. World J Orthop. 2014 Nov 18;5(5):653-9. doi: 10.5312/wjo.v5.i5.653. eCollection 2014 Nov 18. Review. PubMed PMID: 25405094; PubMed Central PMCID: PMC4133473. #Doe K, Nozawa K, Okada T, Tada K, Yamaji K, Tamura N, Takasaki Y. Usefulness of minor salivary gland biopsy in the diagnosis of IgG4-related disease: a case report. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2673-7. eCollection 2014. PubMed PMID: 24966985; PubMed Central PMCID: PMC4069935. #Doe K, Nozawa K（corresponding author）, Hiruma K, Yamada Y, Matsuki Y, Nakano S, Ogasawara M, Nakano H, Ikeda T, Ikegami T, Fujishiro M, Kawasaki M, Ikeda K, Amano H, Morimoto S,Ogawa H, Takamori K, Sekigawa I, Takasaki Y. Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupuserythematosus. Lupus. 2014 May 16. pii: 0961203314536245. [Epub ahead of print] PubMed PMID: 24836587. #Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H,Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab: an anti-interleukin-6 receptor antibody. Biomed Res Int. 2013;2013:607137. doi: 10.1155/2013/607137. Epub 2013 Aug 22. PubMed PMID: 24058910; PubMed Central PMCID: PMC3766614. #Nozawa K（corresponding author）, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Inhibition of connective tissue growth factor ameliorates disease in a murine model of rheumatoid arthritis. Arthritis Rheum. 2013 Jun;65(6):1477-86. doi: 10.1002/art.37902. PubMed PMID: 23436223. #Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, KanekoH, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric tumor necrosis factor-alpha receptor. Int J Rheum Dis. 2012 Oct;15(5):486-95. doi: 10.1111/j.1756-185X.2012.01816.x. Epub 2012 Sep 25. PubMed PMID: 23083039. #Yamaguchi A, Nozawa K（corresponding author）, Fujishiro M, Kawasaki M, Suzuki F, Takamori K, Ogawa H,Takasaki Y, Sekigawa I. CC motif chemokine ligand 13 is associated with rheumatoid arthritis pathogenesis. Mod Rheumatol. 2013 Sep;23(5):856-63. doi: 10.1007/s10165-012-0752-4. Epub 2012 Sep 25. PubMed PMID: 23007802. #Yamaguchi A, Nozawa K（corresponding author）, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis. Immunopharmacol Immunotoxicol. 2012 Oct;34(5):852-7. doi: 10.3109/08923973.2012.664149. Epub 2012 Mar 7. PubMed PMID: 22393877. #Fujishiro M, Nozawa K（corresponding author）, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I. Regenerating gene (REG) 1 alpha promotes pannus progression in patients with rheumatoid arthritis. Mod Rheumatol. 2012 Apr;22(2):228-37. doi:10.1007/s10165-011-0564-y. Epub 2011 Dec 28. PubMed PMID: 22203215. #Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y, TakamoriK, Ogawa H, Sekigawa I. Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus. Lupus. 2011 Oct;20(12):1231-9. doi: 10.1177/0961203311409963. PubMed PMID: 21980035. #Yamada R, Nozawa K（corresponding author）, Yoshimine T, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus Erythematosus: Diagnostic Utility of ADAMTS-13 Activity. Autoimmune Dis. 2011;2011:483642. doi: 10.4061/2011/483642. Epub 2011 Jul 11. PubMed PMID: 21776377; PubMed Central PMCID: PMC3138087. #Doe K, Hohtatsu K, Lee S, Nozawa K, Amano H, Tamura N, Takasaki Y. [Case report: Usefulness of lip biopsy for the diagnosis of IgG4-related diseases with retroperitoneal fibrosis: report of a case]. Nihon Naika Gakkai Zasshi. 2011 Jun 10;100(6):1645-7. Japanese. PubMed PMID: 21770290. #Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y,Takamori K, Ogawa H, Sekigawa I. Fluctuations in the gene expression ofperipheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus. Clin Exp Rheumatol. 2010 May-Jun;28(3):311-7. Epub 2010 Jun 23. PubMed PMID: 20460036. #Sekigawa I, Fujishiro M, Yamaguchi A, Kawasaki M, Inui A, Nozawa K, Takasaki Y, Takamori K, Ogawa H. A new hypothesis of the possible mechanisms of gender differences in systemic lupus erythematosus. Clin Exp Rheumatol. 2010 May-Jun;28(3):419-23. Epub 2010 Jun 23. Review. PubMed PMID: 20460035. #Matsuyama N, Morimoto S, Tokano Y, Amano H, Nozawa K, Isonuma H, Hashimoto H, Takasaki Y. The long-term prognosis of lupus nephritis patients treated with intravenous cyclophosphamide. Intern Med. 2010;49(9):823-8. Epub 2010 Apr 30. PubMed PMID: 20453401.

研究テーマ

膠原病リウマチ内科学

研究業績（論文）

# Nozawa K, Doe K, Uomori K, Sekigawa I, Takasaki Y, Yamaji K, Tamura N.
Antiribonuclease H2 antibodies are an immune biomarker for systemic lupus
erythematosus. Autoimmunity. 2017 May 27:1-6. doi: 10.1080/08916934.2017.1329422.
[Epub ahead of print] PubMed PMID: 28553742.

# Uomori K, Nozawa K（corresponding author）, Ikeda K, Doe K, Yamada Y, Yamaguchi A, Fujishiro M,
Kawasaki M, Morimoto S, Takamori K, Sekigawa I, Chan EK, Takasaki Y. A
re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren's
syndrome: Significant role of interferon-γ in the production of autoantibodies
against NA-14. Autoimmunity. 2016 Jun 21:1-10. [Epub ahead of print] PubMed PMID:
27328271.

#　Matsuki-Muramoto Y, Nozawa K（corresponding author）, Uomori K, Sekigawa I, Takasaki Y. Bortezomib treatment prevents glomerulosclerosis associated with lupus nephritis in a murine
model through suppressive effects on the immune and renin-angiotensin systems.
Mod Rheumatol. 2016 May 11:1-10. [Epub ahead of print] PubMed PMID: 27166507.

# Yamada Y, Nozawa K（corresponding author）, Nakano S, Mitsuo Y, Hiruma K, Doe K, Sekigawa I, Yamanaka K, Takasaki Y. Antibodies to microtubule-associated protein-2 in the
cerebrospinal fluid are a useful diagnostic biomarker for neuropsychiatric
systemic lupus erythematosus. Mod Rheumatol. 2016 Feb 16:1-7. [Epub ahead of
print] PubMed PMID: 26667376.

#Doe K, Nozawa K, Hirai T, Tsushima H, Hayashi E, Hiruma K, Ando S, Nakano S, Kon T, Amano H, Yamaji K, Tamura N, Takasaki Y. Second-to-fourth Digit Ratio in
Systemic Lupus Erythematosus. J Rheumatol. 2015 Mar 1. pii: jrheum.140974. [Epub
ahead of print] PubMed PMID: 25729029.

#Nozawa K（corresponding author）, Fujishiro M, Takasaki Y, Sekigawa I. Inhibition of rheumatoid　arthritis by blocking connective tissue growth factor. World J Orthop. 2014 Nov
18;5(5):653-9. doi: 10.5312/wjo.v5.i5.653. eCollection 2014 Nov 18. Review.
PubMed PMID: 25405094; PubMed Central PMCID: PMC4133473.

#Doe K, Nozawa K, Okada T, Tada K, Yamaji K, Tamura N, Takasaki Y. Usefulness
of minor salivary gland biopsy in the diagnosis of IgG4-related disease: a case
report. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2673-7. eCollection 2014. PubMed PMID: 24966985; PubMed Central PMCID: PMC4069935.

#Doe K, Nozawa K（corresponding author）, Hiruma K, Yamada Y, Matsuki Y, Nakano S, Ogasawara M, Nakano H, Ikeda T, Ikegami T, Fujishiro M, Kawasaki M, Ikeda K, Amano H, Morimoto S,Ogawa H, Takamori K, Sekigawa I, Takasaki Y. Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupuserythematosus. Lupus. 2014 May 16. pii: 0961203314536245. [Epub ahead of print]
PubMed PMID: 24836587.

#Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H,Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis
in patients with rheumatoid arthritis receiving therapy with tocilizumab: an
anti-interleukin-6 receptor antibody. Biomed Res Int. 2013;2013:607137. doi:
10.1155/2013/607137. Epub 2013 Aug 22. PubMed PMID: 24058910; PubMed Central
PMCID: PMC3766614.

#Nozawa K（corresponding author）, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa
I. Inhibition of connective tissue growth factor ameliorates disease in a murine
model of rheumatoid arthritis. Arthritis Rheum. 2013 Jun;65(6):1477-86. doi:
10.1002/art.37902. PubMed PMID: 23436223.

#Yanagida M, Jung G, Tanaka Y, Sone S, Fujishiro M, Ikeda K, Nozawa K, KanekoH, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. Serum proteome analysis in
patients with rheumatoid arthritis receiving therapy with etanercept, a chimeric
tumor necrosis factor-alpha receptor. Int J Rheum Dis. 2012 Oct;15(5):486-95.
doi: 10.1111/j.1756-185X.2012.01816.x. Epub 2012 Sep 25. PubMed PMID: 23083039.

#Yamaguchi A, Nozawa K（corresponding author）, Fujishiro M, Kawasaki M, Suzuki F, Takamori K, Ogawa H,Takasaki Y, Sekigawa I. CC motif chemokine ligand 13 is associated with
rheumatoid arthritis pathogenesis. Mod Rheumatol. 2013 Sep;23(5):856-63. doi:
10.1007/s10165-012-0752-4. Epub 2012 Sep 25. PubMed PMID: 23007802.

#Yamaguchi A, Nozawa K（corresponding author）, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y. Estrogen inhibits apoptosis and promotes CC motif chemokine ligand
13 expression on synovial fibroblasts in rheumatoid arthritis. Immunopharmacol
Immunotoxicol. 2012 Oct;34(5):852-7. doi: 10.3109/08923973.2012.664149. Epub 2012
Mar 7. PubMed PMID: 22393877.

#Fujishiro M, Nozawa K（corresponding author）, Kawasaki M, Yamaguchi A, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Fukui H, Kaneko K, Ogawa H, Takamori K, Takasaki Y, Sekigawa I.
Regenerating gene (REG) 1 alpha promotes pannus progression in patients with
rheumatoid arthritis. Mod Rheumatol. 2012 Apr;22(2):228-37. doi:10.1007/s10165-011-0564-y. Epub 2011 Dec 28. PubMed PMID: 22203215.

#Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y, TakamoriK, Ogawa H, Sekigawa I. Possible role of the JAK/STAT pathways in the regulation
of T cell-interferon related genes in systemic lupus erythematosus. Lupus. 2011
Oct;20(12):1231-9. doi: 10.1177/0961203311409963. PubMed PMID: 21980035.

#Yamada R, Nozawa K（corresponding author）, Yoshimine T, Takasaki Y, Ogawa H, Takamori K, Sekigawa I. A Case of Thrombotic Thrombocytopenia Purpura Associated with Systemic Lupus
Erythematosus: Diagnostic Utility of ADAMTS-13 Activity. Autoimmune Dis.
2011;2011:483642. doi: 10.4061/2011/483642. Epub 2011 Jul 11. PubMed PMID:
21776377; PubMed Central PMCID: PMC3138087.

#Doe K, Hohtatsu K, Lee S, Nozawa K, Amano H, Tamura N, Takasaki Y. [Case
report: Usefulness of lip biopsy for the diagnosis of IgG4-related diseases with
retroperitoneal fibrosis: report of a case]. Nihon Naika Gakkai Zasshi. 2011 Jun
10;100(6):1645-7. Japanese. PubMed PMID: 21770290.

#Kawasaki M, Fujishiro M, Yamaguchi A, Nozawa K, Kaneko H, Takasaki Y,Takamori K, Ogawa H, Sekigawa I. Fluctuations in the gene expression ofperipheral blood mononuclear cells between the active and inactive phases of systemic lupus erythematosus. Clin Exp Rheumatol. 2010 May-Jun;28(3):311-7. Epub
2010 Jun 23. PubMed PMID: 20460036.

#Sekigawa I, Fujishiro M, Yamaguchi A, Kawasaki M, Inui A, Nozawa K, Takasaki
Y, Takamori K, Ogawa H. A new hypothesis of the possible mechanisms of gender
differences in systemic lupus erythematosus. Clin Exp Rheumatol. 2010
May-Jun;28(3):419-23. Epub 2010 Jun 23. Review. PubMed PMID: 20460035.

#Matsuyama N, Morimoto S, Tokano Y, Amano H, Nozawa K, Isonuma H, Hashimoto H,
Takasaki Y. The long-term prognosis of lupus nephritis patients treated with
intravenous cyclophosphamide. Intern Med. 2010;49(9):823-8. Epub 2010 Apr 30.
PubMed PMID: 20453401.

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研究業績詳細

野澤 和久（ノザワ カズヒサ）

野澤和久（ノザワカズヒサ）