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本井ゆみ子（モトイユミコ）

研究テーマ	認知症の基礎および臨床研究
研究業績（論文）	2024年 1)Ahmed Imtiaz,Shotaro Shimonaka,Mohammad Nasir Uddin, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori and Yumiko Motoi. Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates. Frontiers in Aging Neuroscience 26 March 2024 DOI 10.3389/fnagi.2024.1368291 2)Kazuo Yamashiro, Kaito Takabayashi, Koji Kamagata, Yuichiro Nishimoto,Yuka Togashi, Yohsuke Yamauchi, Kotaro Ogaki, Yuanzhe Li, Taku Hatano,Yumiko Motoi, Michimasa Suzuki, Koichi Miyakawa, Dai Ishikawa, Shigeki Aoki , Takao Urabe, Nobutaka Hattor Free water in gray matter linked to gut microbiota changes with decreased butyrate producers in Alzheimer's disease and mild cognitive impairment. Neurobiology Dis.193(2024)106464 2018年 1) Takeshige H, Nakayama S, Nishioka K, Yuanzhe Li, Motoi Y, Hattori N. "Marked reduction in striatal dopamine transporter uptake during the early stage of motor symptoms in patients with the MAPT N279K mutation Intern Med 57: 3015-3019, 2018 2) Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H. Change of Amyloid-_ 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus. J Alz Dis 63 (2018) 989–1002 3) Andica C, Kamagata K, Hatano T, Okuzumi A, Saito A, Nakazawa M, Ueda R, Motoi Y, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S. Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson’s disease: Retrograde degeneration observed by tract-profile analysis. Parkinsonism Relat Disord. 2018 June;51:55-60 4) Yano K, Hirayama S, Misawa N, Furuta A, Ueno T, Motoi Y, Seino U, Ebinuma H, Ikeuchi T, Shneider WJ, Bujo H, Miida T. Soluble LR11 competes with amyloid  binding to cerebrospinal fluid-high-density lipoprotein. Clin Chim Acta 2019 Feb:489:29-34 2017年 1) Nakayama S, Suda A, Nakanishi A, Motoi Y, Hattori N. Galantamine Response Associates with Agitation and the Prefrontal Cortex in Patients with Alzheimer's Disease. J Alzheimers Dis. 2017;57(1):267-273. 2) Hara Y, Motoi Y, Hikishima K, Mizum H, Onoe H, Matsumoto SE, Elahi M, Okano H, Aoki S, Hattori N Involvement of the septo-hippocampal cholinergic pathway in association with septal acetylcholinesterase upregulation in a mouse model of tauopathy.　Hara.　 Curr Alzheimer Res. 2017;14(1):94-103. IP 2.197 3) Matsushima T, Conedera S, Tanaka R, Li Y, Yoshino H, Funayama M, Ikeda A, Hosaka Y, Okuzumi A, Shimada Y, Yamashiro K, Motoi Y, Nishioka K, Hattori N. Genotype-phenotype correlations of cysteine replacement in CADASIL. Neurobiol Aging. 2017 Feb;50:169.e7-169.e14 4) Yamamoto H, Arimura S, Nakanishi A, Shimo Y, Motoi Y, Ishiguro K, Murakami K, Hattori N, Aoki S. Age-related effects and gender differences in Japanese Healthy controls for [123I]FP-CIT SPECT. Ann Nucl Med Ann Nucl Med 2017 Jun 31 (5) 407 2016年 Nishioka K, Hayashi T,Suzuki M, Li Y, Nakayama S, Matsushima T, Usui T, Sshibata N, Motoi Y, Tanaka R, Nishioka K, Hattori N. Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series. International J of Rhermatic Disease 2016 Jan;19(1):21-9 1.469 2) Elahi M, Motoi Y, Matsumoto S, Hasan Z, Ishiguro K, Hattori N. Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice. Neurosci. Lett. 610　(2016)207-212.　　IP 2.107 3) Elahi M, Hasan Z, Motoi Y, Matsumoto S, Ishiguro K, Hattori N. Region-specific vulnerability to oxidative stress, Neuroinflammation, and Tau hyperphosphorylation in experimental diabetes Mellitis mice. J Alz Dis. 2016 Feb 25;51(4):1209-1224 IP 3.290 4) Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagaa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study. Int J Geriatr Psychiatry 2016 DOI:10.1002/gps.4600 5) Suzuki A1, Shibata N1, Kasanuki K1, Nagata T2, Shinagawa S3, Kobayashi N3, Ohnuma T1, Takeshita Y1, Kawai E1,Takayama T1, Nishioka K4, Motoi Y4, Hattori N4, Nakayama K3, Yamada H5, Arai H1. Shibata Genetic association between presenilin 2 polymorphisms and Alzheimer's disease and dementia of Lewy body type in a Japanese population. Dementia and Geriatric Cognitive Disorders Extra Dement Geriatr Cogn Dis Extra. 2016 Mar 16;6(1):90-7 2014年 1. Ishikawa KI, Motoi Y, Mizuno Y, Kubo SI, Hattori N. Effect of dose escalation in Parkinson7s patients with dementia receiving long-term donepezil treatment: an exploratory study. Psychogeriatrics. 2014 2. Motoi Y, Shimada K, Ishiguro K, Hattori N. Lithium and autophagy. ACS Chem Neurosci. 2014 Apr 16 2013年まで 1. Shimada K, Motoi Y, Ishiguro K, Kambe T, Matsumoto S, Itaya M, Kunichika M, Mori H, Shinohara S, Chiba M, Mizuno Y, Ueno T, Hattori N. Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion. Neurobiol Dis. 46 2012 101-108 2. Kamagata K, Motoi Y, Abe O, Shimoji K, Hori M, Nakanishi A, Sano T, Kuwatsuru R, Aoki S, Hattori N. White matter alterlation of the cingulum in Parkinson's disease with and without dementia: evaluation by diffusion tensor tract-specific analysis. AJNR 33:890- 3. Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N.Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Neurobiol Dis. 42 (2011) 404-414. 4. Kamakagata K, Motoi Y, Shimogi K, Nakanishi A, Hori M, Mizuno Y, Hattori N, Aoki S. posterior hypoperfusion in Parkinson's disease and Parkinson's disease with dementia measured with arterial spin-labering MR imaging.J MRI 33:803-807 (2011) 5. Ogaki K, Motoi Y, Li Y, Tomiyama H, Shimizu N, Takanashi M, Nakanishi A, Yokoyama K, Hattori N. Visual grasping in FTDP-17 (MAPT): A comparison of N-isopropyl-p-[(123)I]-iodoamphetamine brain perfusion single photon emission computed tomography analysis with PSP.Mov Disord 2011, 26(3) 561-563.

研究テーマ

認知症の基礎および臨床研究

研究業績（論文）

2024年
1)Ahmed Imtiaz,Shotaro Shimonaka,Mohammad Nasir Uddin,
Montasir Elahi, Koichi Ishiguro, Masato Hasegawa,
Nobutaka Hattori and Yumiko Motoi. Selection of lansoprazole from an FDA-approved drug library to inhibit the Alzheimer’s disease seed-dependent formation of tau aggregates. Frontiers in Aging Neuroscience 26 March 2024
DOI 10.3389/fnagi.2024.1368291
2)Kazuo Yamashiro, Kaito Takabayashi, Koji Kamagata, Yuichiro Nishimoto,Yuka Togashi, Yohsuke Yamauchi, Kotaro Ogaki, Yuanzhe Li, Taku Hatano,Yumiko Motoi, Michimasa Suzuki, Koichi Miyakawa, Dai Ishikawa, Shigeki Aoki ,
Takao Urabe, Nobutaka Hattor Free water in gray matter linked to gut microbiota changes with decreased
butyrate producers in Alzheimer's disease and mild cognitive impairment. Neurobiology Dis.193(2024)106464
2018年
1) Takeshige H, Nakayama S, Nishioka K, Yuanzhe Li, Motoi Y, Hattori N.
"Marked reduction in striatal dopamine transporter uptake during the early stage of motor symptoms in patients with the MAPT N279K mutation Intern Med 57: 3015-3019, 2018
2) Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H. Change of Amyloid-_ 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus. J Alz Dis 63 (2018) 989–1002
3) Andica C, Kamagata K, Hatano T, Okuzumi A, Saito A, Nakazawa M, Ueda R, Motoi Y, Kamiya K, Suzuki M, Hori M, Kumamaru KK, Hattori N, Aoki S. Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson’s disease: Retrograde degeneration observed by tract-profile analysis. Parkinsonism Relat Disord. 2018 June;51:55-60
4) Yano K, Hirayama S, Misawa N, Furuta A, Ueno T, Motoi Y, Seino U, Ebinuma H, Ikeuchi T, Shneider WJ, Bujo H, Miida T. Soluble LR11 competes with amyloid  binding to cerebrospinal fluid-high-density lipoprotein. Clin Chim Acta 2019 Feb:489:29-34

2017年
1) Nakayama S, Suda A, Nakanishi A, Motoi Y, Hattori N. Galantamine Response Associates with Agitation and the Prefrontal Cortex in Patients with Alzheimer's Disease. J Alzheimers Dis. 2017;57(1):267-273.
2) Hara Y, Motoi Y, Hikishima K, Mizum H, Onoe H, Matsumoto SE, Elahi M, Okano H, Aoki S, Hattori N Involvement of the septo-hippocampal cholinergic pathway in association with septal acetylcholinesterase upregulation in a mouse model of tauopathy.　Hara.　 Curr Alzheimer Res. 2017;14(1):94-103. IP 2.197
3) Matsushima T, Conedera S, Tanaka R, Li Y, Yoshino H, Funayama M, Ikeda A, Hosaka Y, Okuzumi A, Shimada Y, Yamashiro K, Motoi Y, Nishioka K, Hattori N. Genotype-phenotype correlations of cysteine replacement in CADASIL. Neurobiol Aging. 2017 Feb;50:169.e7-169.e14
4) Yamamoto H, Arimura S, Nakanishi A, Shimo Y, Motoi Y, Ishiguro K, Murakami K, Hattori N, Aoki S. Age-related effects and gender differences in Japanese Healthy controls for [123I]FP-CIT SPECT. Ann Nucl Med Ann Nucl Med 2017 Jun 31 (5) 407

2016年
Nishioka K, Hayashi T,Suzuki M, Li Y, Nakayama S, Matsushima T, Usui T, Sshibata N, Motoi Y, Tanaka R, Nishioka K, Hattori N. Fibromyalgia syndrome and cognitive dysfunction in elderly: a case series. International J of Rhermatic Disease 2016 Jan;19(1):21-9 1.469
2) Elahi M, Motoi Y, Matsumoto S, Hasan Z, Ishiguro K, Hattori N. Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice. Neurosci. Lett. 610　(2016)207-212.　　IP 2.107
3) Elahi M, Hasan Z, Motoi Y, Matsumoto S, Ishiguro K, Hattori N. Region-specific vulnerability to oxidative stress, Neuroinflammation, and Tau hyperphosphorylation in experimental diabetes Mellitis mice. J Alz Dis. 2016 Feb 25;51(4):1209-1224 IP 3.290
4) Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagaa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H. Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study. Int J Geriatr Psychiatry 2016 DOI:10.1002/gps.4600
5) Suzuki A1, Shibata N1, Kasanuki K1, Nagata T2, Shinagawa S3, Kobayashi N3, Ohnuma T1, Takeshita Y1, Kawai E1,Takayama T1, Nishioka K4, Motoi Y4, Hattori N4, Nakayama K3, Yamada H5, Arai H1. Shibata Genetic association between presenilin 2 polymorphisms and Alzheimer's disease and dementia of Lewy body type in a Japanese population. Dementia and Geriatric Cognitive Disorders Extra Dement Geriatr Cogn Dis Extra. 2016 Mar 16;6(1):90-7

2014年
1. Ishikawa KI, Motoi Y, Mizuno Y, Kubo SI, Hattori N. Effect of dose escalation in Parkinson7s patients with dementia receiving long-term donepezil treatment: an exploratory study. Psychogeriatrics. 2014
2. Motoi Y, Shimada K, Ishiguro K, Hattori N. Lithium and autophagy. ACS Chem Neurosci. 2014 Apr 16
2013年まで
1. Shimada K, Motoi Y, Ishiguro K, Kambe T, Matsumoto S, Itaya M, Kunichika M, Mori H, Shinohara S, Chiba M, Mizuno Y, Ueno T, Hattori N. Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion. Neurobiol Dis. 46 2012 101-108
2. Kamagata K, Motoi Y, Abe O, Shimoji K, Hori M, Nakanishi A, Sano T, Kuwatsuru R, Aoki S, Hattori N. White matter alterlation of the cingulum in Parkinson's disease with and without dementia: evaluation by diffusion tensor tract-specific analysis. AJNR 33:890-
3. Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N.Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice. Neurobiol Dis. 42 (2011) 404-414.
4. Kamakagata K, Motoi Y, Shimogi K, Nakanishi A, Hori M, Mizuno Y, Hattori N, Aoki S. posterior hypoperfusion in Parkinson's disease and Parkinson's disease with dementia measured with arterial spin-labering MR imaging.J MRI 33:803-807 (2011)
5. Ogaki K, Motoi Y, Li Y, Tomiyama H, Shimizu N, Takanashi M, Nakanishi A, Yokoyama K, Hattori N. Visual grasping in FTDP-17 (MAPT): A comparison of N-isopropyl-p-[(123)I]-iodoamphetamine brain perfusion single photon emission computed tomography analysis with PSP.Mov Disord 2011, 26(3) 561-563.

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研究業績詳細

本井 ゆみ子（モトイ ユミコ）

本井ゆみ子（モトイユミコ）