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平澤恵理（ヒラサワエリ）

研究テーマ	神経筋疾患における細胞外マトリックスの研究
研究業績（論文）	1.なし 2.なし 3. 4. 5. 6. 著書 1.Arikawa-Hirasawa E. Role of perlecan in developmentand disease. Extracellular Matrix in Development and Disease edited by Jeffrey Miner, Elsevir Advances in Developmental Biology and Biochemistry, volume 15　p65-80 2005 2.Annual Review 神経　2004 分担執筆　p286-292中外医学社XIV. 筋疾患　Schwartz-Jampel症候群（軟骨異栄養性筋強直症）とパールカン原著論文 1 Sunohara N, Arahata K, Hoffman EP, Yamada H, Nishimiya J, Arikawa E. Kaido M, Nonaka I, and Sugita H：Quadriceps myopathy:form fruste of Becker muscular dystrophy. Annals of Neurology, 28:634-639,1990. 2 ○Arikawa E,Ishihara T, Nonaka I, Sugita H, and Arahata K：Immunocytochemical analysis of dystrophin in congenital muscular dystrophy. Journal of the Neurological Science, 105:79-87,1991. 3 ○Arikawa E, Hoffman EP, Kaido M, Nonaka I, and Arahata K:The requency of patients with dystrophin abnormalities in a limb-girdle patient population. Neurology, 41:1491-1496, 1991. 4 Arahata K, Beggs AH, Honda H, Ito S, Ishiura S, Tsukahara T, Ishiguro T, Eguchi C, Orimo S, Arikawa E, Kaido M, Nonaka I, Sugita H, and Kunkel LM: Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy. Journal of the Neurological Sciences, 101:148-156,1991. 5 Beggs AH, Neumann E, Arahata K, Arikawa E. Nonaka I, Anderson MS, and Kunkel LM: Possible influences on the expression of X chromosome linked dystrophin abnormalities by heterozygosity for autosomal recessive Fukuyama congenital muscular dystrophy. Proc. Natl. Acad. Sci. U.S.A., 89:6623-6627,1992. 6 Udd B, Rapola J, Arikawa E, and Somer H: Nonvacuolar myopathy in a large family with both late adult onset distal myopathy and severe proximal muscular dystrophy. Journal of the Neurological Sciences, 113:214-221,1992. 7 Hoffman EP, Arahata K, Minetti C, Bonilla E, Rowland LP, and Co-Authors：Dystrophinopathy in isolated cases of myopathy in females． Neurology 42;967-975,1992 8 Hayashi YK, Engvall E, Arikawa-Hirasawa E, Goto K, Koga R, Nonaka I, Sugita H, and Arahata K: Abnormal localization of laminin subunits in muscular dystrophies. Journal of the Neurological Sciences,19:53-61,1993. 9 ○Arikawa-Hirasawa E, Koga R, Tsukahara T, Nonaka I, Mitsudome A, Goto K, Beggs AH, and Arahata K: A severe muscular dystrophy patient with an internally deleted very short (110 kD) dystrophin: presence of the binding site for dystrophin-associated glycoprotein (DAG) may not be enough for physiological function of dystrophin．Neuromusclar Disorders, 5:429-438,1995 10 Yamanouchi Y, Arikawa E, Arahata K, Ozawa E, and Nonaka I. Limb-girdle muscular dystrophy: Clinical and pathologic reevaluation, Journal of the Neurological Sciences, 129:15-20,1995. 11 Tumaki N, Tanaka K, Arikawa-Hirasawa E, Nakase T, Kimura T, Thomas JT, Ochi T, Luyten FP, and Yamada Y: Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation. Journal of Cell Biology,144:161-173,1999 12 ○Arikawa-Hirasawa E, Watanabe H, Takami H, Hassell JR, and Yamada Y: Perlecan is essential for cartilage and cephalic development. Nature Genetics, 23:354-358,1999. 13 Fleischmajer R, Kuroda K, Utani A, Douglas MacDonald E, Perlish JS, Arikawa-Hirasawa E, Sekiguchi K, Sanzen N, Timpl R, and Yamada Y: Differential expression of laminin alpha chains during proliferative and differentiation stages in a model for skin morphogenesis. Matrix Biology,19:637-647,2000. 14 ○Arikawa-Hirasawa E, Wilcox RL, Govindraj P, Hassell JR, Yamada Y: Dyssegmental dysplasia, Silverman-Handmaker type, is caused by a functional null mutation of perlecan. Nature Genetics, 27: 431-434. 2001 15 ○Arikawa-Hirasawa E and Yamada Y. Perlecan mutations in mice and humans: critical role of perlecan in skeletal development and disease. Acta Myologica, 20:134-137. 2001 16 ○Arikawa-Hirasawa E, Le AH , Nishino I, Nonaka I, Ho NC , Francomano CA, Govindraj P, Hassell JR, Devaney JM , Spranger J, Stevenson RH, Iannaccone S, Dalakas MC, and Yamada Y. Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia. Am. J. Hum. Gen., 70:1368-1375 2001 17 ○Arikawa-Hirasawa E, Rossi SG, Rotundo RL, and Yamada Y. Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice. Nature Neuroscience, 5:119-123, 2002. 18 Yuasa K, Fukumoto S, Kamasaki Y, Yamada A, Fukumoto E, Kanaoka K, Saito K, Harada H, Arikawa-Hirasawa E, Miyagoe-Suzuki Y, Takeda S, Okamoto K, Kato Y, Fujiwara T. Laminin alpha2 essential for odontoblast differentiation regulating dentin sialoprotein expression. 279(11):10286-92. J Biol Chem. 2004 19 Vikramadithyan RK, Kako Y, Chen G, Hu Y, Arikawa-Hirasawa E, Yamada Y, Goldberg IJ. Atherosclerosis in perlecan heterozygous mice. J Lipid Res. Oct;45(10):1806-12.2004 20 Ichikawa N, Kasai S, Suzuki N, Nishi N, Oishi S, Fujii N, Kadoya Y, Hatori,K Mizuno Y, Nomizu M, and Arikawa-Hirasawa E Identification of neurite outgrowth active sites on the laminin alpha4 chain G domain. Biochemistry ;44(15):5755-5762. ;2005 21 Sugie K, Noguchi S, Kozuka Y, Arikawa-Hirasawa E, Tanaka M, Yan C, Saftig P, von Figura K, Hirano M, Ueno S, Nonaka I, Nishino I. Autophagic Vacuoles with Sarcolemmal Features Delineate Danon Disease and Related Myopathies. J Neuropathol Exp Neurol　Vol. 64, No. 6 pp. 513–522,2005 22 Sher, I., Zisman-Rozen, S., Eliahu L, Whitelock JM, Maas-Szabowski N, Yamada Y, Breitkreutz D, Fusenig NE, Arikawa-Hirasawa E, Iozzo RV, Bergman R, Ron D. Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation. J. Biol. Chem., Vol. 281, (8), 5178-5187, February 24, 2006 23 Kerever A, Schnack J, Vellinga D, Ichikawa N, Moon C, Arikawa-Hirasawa E, Efird JT Mercier F. Novel Extracellular Matrix Structures in the Neural Stem Cell Niche Capture the Neurogenic Factor FGF-2 from the Extracellular Milieu Stem Cells Sep ;25(9):2146-57. 2007 24 Awamura Y, Uchida K, Arikawa-Hirasawa E. Long-term follow-up of laminin alpha2 (merosin)-deficient muscular dystrophy in a cat 　J Feline Med Surg. 10, 274-279, 2008 25 Arimura T, Hayashi YK, Murakami T, Oya Y, Funabe S, Arikawa-Hirasawa E, Hattori N, Nishino I and Kimura A.Mutational analysis of Fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy Circulation Journal Jan;73(1):158-61, 2009 26 Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi ,Sasaki T, Hattori N,Mizuno Y, Hozumi K, Yamada Y, and Arikawa-Hirasawa E. Binding of laminin-1 to GM1 ganglioside in lipid rafts is critical forneurite outgrowth. J Cell Sci. Jan 15;122:289-99, 2009 27 Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T. Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia Neuropsychopharmacolog. 2010 Apr;35(5):1155-64. Epub Jan 13. 2010 . 28 Sakamoto Y, Ishijima M, Kaneko H, Kurebayashi N, Ichikawa N, Futami I, Kurosawa H, Arikawa-Hirasawa E Distinct Mechanosensitive Ca2+ Influx Mechanisms in Human Primary Synovial Fibroblasts J Orthop Res. 28:859-864, 2010 Jan 27[Epub ahead of print] 29 Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E, Mochizuki H, Kohsaka S, Uchino S. Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-d-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells. Neuroscience. 2010 May 5;167(2):372-83. Epub Jan 28. 2010 30 Xu Z, Ichikawa N, Kosaki K, Yamada Y, Sasaki T, Sakai LY Kurosawa H, Hattori N, Arikawa-Hirasawa E. Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition Matrix Biol. 2010 Jul;29(6):461-70. Jun 9. [Epub ahead of print] 2010 31 Sasaki T, Takagi J, Giudici C, Yamada Y, Arikawa-Hirasawa E, Deutzmann R, Timpl R, Sonnenberg A, Bächinger HP, Tonge D.Laminin-121-Recombinant expression and interactions with integrins. Matrix Biol. 2010 Jul;29(6):484-93. 32 Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E, Kubota M, Liu L, Xu Z, Futami I, Yusup A, Miyahara K, Xu S, Kaneko K, Kurosawa H, Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis, Int. Orthop.2011 Jun;35(6):831-8. Epub 2010Jun 2, 2010 [Epub ahead of print] 33 Chyba M, Mercier F, RaderJ, Douet V Arikawa-Hirasawa E, Kwon YC, Kodama R Dynamic mathematical modeling of cell-fractone interactions　 Journal of Math-for-Industry, Vol. 3 (2011A-8), pp. 79–88 34 Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai,T, Kohsaka S, Chiba H, Hattori H, Yamada Y, and Arikawa-Hirasawa E.　Laminin a1 is essential for mouse cerebellar development　 Matrix Biol. 31(1)January, Pages 17–28 2012 35 Mercier F, Arikawa-Hirasawa E: Heparan sulfate niche for cell proliferation in the adult brain. Neuroscience Letters 2012 Feb 29;510(2):67-72. doi: 10.1016/j.neulet.2011.12.046. Epub 2011 Dec 31. 36 Yoshinaga H, Sakoda,S Good JM, Takahashi MP, Kubota T, Arikawa-Hirasawa E, Nakata T, Ohno K, Kitamura T, Kobayashi K, and Ohtsuka Y: A novel mutation in SCN4A causes severe myotonia and school-age-onset paralytic episodes. Journal of the Neurological Sciences Apr 15;315(1-2):15-9 2012 37 Inomata T , Ebihara N, Funaki, T Matsuda A, Watanabe Y, Ning L, Xu Z, Murakami A, Arikawa-Hirasawa E: Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure, Invest Ophthalmol Vis Sci.、Mar 9;53(3):1277-84., 2012 38 Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012 Mar 7. May;31(4):234-45 2012. Epub 2012 Mar 7 Epub ahead of print 39 Suzuki N, Fukushi M, Kosaki K, Doyle AD, de Vega S, Yoshizaki K, Akazawa C, Arikawa-Hirasawa E, Yamada Y Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS..J Neurosci. Aug 22;32(34):11586-99. 2012 40 Futami I, Ishijima M, Kaneko H, Tsuji K, Ichikawa-Tomikawa N, Sadatsuki R, Muneta T, Arikawa-Hirasawa E, Sekiya I, Kaneko K Isolation and Characterization of MultipotentialMesenchymal Cells from the Mouse Synovium. PLoS ONE 7(9): e45517 1-12　2012 41 Douet V, Arikawa-Hirasawa E, Mercier F. Fractone-heparan sulfates mediate BMP-7 inhibition of cell proliferation in the adult subventricular zone. Neurosci Lett. Neurosci Lett. 2012 Oct 24;528(2):120-5. 2012. Epub 2012 Sep 7. 42 Douet V, Arikawa-Hirasawa E, Mercier F Fractone-heparan sulfates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone. Cell Prolif. 2013 Apr;46(2):137-45. 43 Nakazawa N, Miyahara K, Okawada M, Yamataka A, Suzuki R, Akazawa C, Tomikawa-Ichikawa N, Arikawa-Hirasawa E. Laminin-1 promotes enteric nervous system development in mouse embryo. Pediatr Surg Int. 2013 Nov;29(11):1205-8. 44 Suzuki N, Numakawa T • Joshua Chou J, de Vega, S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi N, Arikawa-Hirasawa E, Yamada Y, Akazawa C. Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling . The FASEB Journal article fj.13-241034. Published online. 2014 Mar;28(3):1386-97. doi: 10.1096/fj.13-241034. Epub 2013 Dec 16. 45 Kerever A Mercier F, Nonaka R, de Vega S, Oda Y, Zalc B, Okada Y, Hattori N, Yamada Y, Arikawa-Hirasawa, Perlecan is required for FGF-2 signaling in the neural stem cell niche. Stem Cell Res. 2013 Dec 28;12(2):492-505. 46 Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014 Jan 21;10(4). [Epub ahead of print] 47 de Vega S, Suzuki N, Nonaka R, Sasaki T, Forcinito P, Arikawa-Hirasawa E, Yamada Y. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture. Arch Biochem Biophys. 2014 Jan 27 48 Ning L, Kurihara H, de Vega S,* Ichikawa-Tomikawa n, Xu Z,Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-HirasawA E, Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGFβ pathway The American Journal of Pathology . 2014 Jun;184(6):1683-94 48 Ning L, Kurihara H, de Vega S,* Ichikawa-Tomikawa n, Xu Z,Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-Hirasawa E, Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGFβ pathway The American Journal of Pathology . 2014 Jun;184(6):1683-94.doi: 10.1016/j.ajpath.2014.02.006. Epub 2014 Apr 8 Nonaka R, Iesaki T, de Vega S, Daida H, Okada T, Sasaki T, and Arikawa-Hirasawa E Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase. Physiol Rep. 2015 Jan 27;3(1). pii: e12272. doi: 10.14814/phy2.12272. Print 2015 Jan 1. 49 Kerever A, Kamagata K, Yokosawa S, Otake Y, Ochi H, Yamada T, Hori M, Kamiya K, Nishikori A, Aoki S, Arikawa-Hirasawa E. See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Magnetic Resonance in Medical Sciences 14(2):159-62. 2015 doi: 10.2463/mrms.2014-0142. Epub 2015 Mar 31　 50 Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K. A missense mutation in domain III in HSPG2 in Schwartz–Jampel syndrome compromises secretion of perlecan into the extracellular space　Neuromuscul Disord. Aug;25(8):667-71. doi: 10.1016/j.nmd.2015.05.002. Epub 2015 May 8.　2015 51 Kerever A, Yamada T, Suzuki Y Mercier F, Arikawa-Hirasawa, E Fractone aging in the subventricular zone of the lateral ventricle" J Chem Neuroanat. 2015 Jul-Sep;66-67:52-60. Doi10.1016/j.jchemneu.　2015.06.001. Epub 2015 Jun 14. 52 Ning L, Xu Z, Furuya N, Nonaka R, Yamada Y, Arikawa-Hirasawa E. Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle. Matrix Biol. 2015 Oct;48:263 doi:10.1016/j.matbio.2015.08.002. Epub 2015 Aug 28.5310.1016/j.matbio.2015.08.002. 53 de Vega S, Hozumi K, Suzuki N, Nonaka R, Seo E, Takeda A, Ikeuchi T, Nomizu M, Yamada Y, Arikawa-Hirasawa E.Identification of Peptides Derived from the C-terminal Domain of Fibulin-7 Active for Endothelial Cell Adhesion and Tube Formation Disruption. Biopolymers. 2015 Oct 22. doi: 10.1002/bip.22754. 54 Kamagata K, Kerever A, Yokosawa S, Otake Y, Ochi H, Hori M, Kamiya K, Tsuruta K, Tagawa K, Okazawa H, Aoki S, Arikawa-Hirasawa E. Quantitative Histological Validation of Diffusion Tensor MRI with Two-Photon Microscopy of Cleared Mouse Brain.Magn Reson Med Sci. 2016 Mar 30. 55 Sadatsuki R, Kaneko H, Kinoshita M, Futami I, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M.　Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.J Orthop Res doi: J Orthop Res. 2017 Apr;35(4):837-846. doi: 10.1002/jor.23318. 56 Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E. 　Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche. J Neurochem. 2017 May 26. doi: 10.1111/jnc.14081. 57 Sato K, Kerever A, Kamagata K, Tsuruta K, Irie R, Tagawa K, Okazawa H, Arikawa-Hirasawa E, Nitta N, Aoki I, Aoki S. Understanding microstructure of　he brain by comparison of neurite　orientation dispersion and density　imaging (NODDI) with transparent　mouse brain　 Acta Radiol Open. 2017 Apr 17;6(4):2058460117703816. doi: 10.1177/2058460117703816. 59 Fujiwara N, Nakazawa-Tanaka N, Miyahara K, Arikawa-Hirasawa E, Akazawa C, Yamataka A.Altered expression of laminin alpha1 in aganglionic colon of endothelin receptor-B null mouse model of Hirschsprung's disease. Pediatr Surg Int. 2018Feb;34(2):137-141. Doi 10.1007/s00383-017-4180-6. [Epub ahead of print Oct 5 2017]PMID: 28983681 60 Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche. J Neurochem. 2017 Aug;142(4):534-544. doi: 10.1111/jnc.14081. Epub 2017 Jun 20. 61 Nakazawa-Tanaka N, Fujiwara N, Miyahara K, Nakada S, Arikawa-Hirasawa E, Akazawa C, Urao M, Yamataka A.The effect of laminin-1 on enteric neural crest-derived cell migration in the Hirschsprung's disease mouse model. Pediatr Surg Int. 2018 Apr 10;17(2):138-144 doi: 10.1007/s00383-017-4181-5. [Epub ahead of print] PMID: 29018955 62 Irie R, Kamagata K, Kerever A, Ueda R, Yokosawa S, Otake Y, Ochi H, Yoshizawa H, Hayashi A, Tagawa K, Okazawa H, Takahashi K, Sato K, Hori M, Arikawa-Hirasawa E, Aoki S.The Relationship between Neurite Density Measured with Confocal Microscopy in a Cleared Mouse Brain and Metrics Obtained from Diffusion Tensor and Diffusion Kurtosis Imaging. Magn Reson Med Sci. 2018 Apr 10;17(2):138-144. doi: 10.2463/mrms.mp.2017-0031. 63 Yamashita Y, Nakada S, Yoshihara T, Nara T, Furuya N, Miida T, Hattori N, Arikawa-Hirasawa E. Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep. 2018 May 17;8(1):7766. doi: 10.1038/s41598-018-25635-x. PMID:29773865 64 Ikeuchi T, de Vega S, Forcinito P, Doyle AD, Amaral J, Rodriguez IR, Arikawa-Hirasawa E, Yamada Y. Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity. Sci Rep. 2018 Dec 5;8(1):17654. 65 de Vega S, Kondo A, Suzuki M, Arai H, Jiapaer S, Sabit H, Nakada M, Ikeuchi T, Ishijima M, Arikawa-Hirasawa E, Yamada Y, Okada Y. Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1. Int J Cancer. 2019 Mar 28. doi: 10.1002/ijc.32306. 66 Yoshimura Y, Ishijima M, Ishibashi M, Liu L, Arikawa-Hirasawa E, Machida S, Naito H, Hamada C, Kominami E. A nationwide observational study of locomotive syndrome in Japan using the ResearchKit: The Locomonitor study J Orthop Sci. 2019 Nov;24(6):1094-1104. doi: 10.1016/j.jos.2019.08.009. 67 Nakamura K, Ikeuchi T, Nara K, Rhodes CS, Zhang P, Chiba Y, Kazuno S, Miura Y, Ago T, Arikawa-Hirasawa E, Mukouyama YS, Yamada Y.Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier J Cell Biol . 2019 Oct 7;218(10):3506-3525. 68 Nakada S, Yamashita Y, Machida S, Miyagoe-Suzuki Y, Arikawa-Hirasawa E. Perlecan Facilitates Neuronal Nitric Oxide Synthase Delocalization in Denervation-Induced Muscle Atrophy Cells. 2020 Nov 23;9(11):2524. doi:10.3390/cells9112524.doi: 10.1083/jcb.201807178. 69 Kerever A, Nagahara F, Keino-Masu K, Masu M, van Kuppevelt TH, Vivès RR, Arikawa-Hirasawa E.Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches Glycobiology. 2021 Jul 29;cwab081. doi: 10.1093/glycob/cwab081. 70 Nonaka R, Iesaki T, Kerever A, Arikawa-Hirasawa E Increased Risk of Aortic Dissection with Perlecan Deficiency. Int J Mol Sci. 2021 23(1):315. 71 Tsuji Y, Kerever A, Furukawa T, Kamagata K, Saito Y, Aoki S, Hata J, Okano H, Kobayashi K, Okada T, Miya K, Keino-Masu K, Masu M, Arikawa-Hirasawa E Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain. Magn Reson Imaging. 2022 88:123-131 72 Nakada S, Yamashita Y, Akiba S, Shima T, Arikawa-Hirasawa E. Myocyte Culture with Decellularized Skeletal Muscle Sheet with Observable Interaction with the Extracellular Matrix. Bioengineering (Basel). 12;9(7):309. 2022 doi: 10.3390/bioengineering9070309. 73 Arikawa-Hirasawa E Impact of the heparan sulfate proteoglycan perlecan on human disease and health. Am J Physiol Cell Physiol . 2022 Jun 1;322(6):C1117-C1122. doi: 10.1152/ajpcell.00113.2022 74 Hayashiji N, Kawahara G, Xu X, Fukuda T, Kerever A, Gu J, Hayashi YK, Arikawa-Hirasawa E. α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish. Cells. 2022 Dec 29;12(1):144.doi: 10.3390/cells12010144. 75 Yamashita Y, Nakada S, Nakamura K, Sakurai H, Ohno K, Goto T, Mabuchi Y, Akazawa C, Hattori N, Arikawa-Hirasawa E. Evaluation of Human-Induced Pluripotent Stem Cells Derived from a Patient with Schwartz-Jampel Syndrome Revealed Distinct Hyperexcitability in the Skeletal MusclesBiomedicines. 2023 Mar 7;11(3):814. doi: 10.3390/biomedicines11030814. 76. Kanazawa A, Fujibayashi K, Watanabe Y, Kushiro S, Yanagisawa N, Fukataki Y, Kitamura S, Hayashi W, Nagao M, Nishizaki Y, Inomata T, Arikawa-Hirasawa E, Naito T. Evaluation of a Medical Interview-Assistance System Using Artificial Intelligence for Resident Physicians Interviewing Simulated Patients: A Crossover, Randomized, Controlled Trial. Int J Environ Res Public Health. 2023 Jun 19;20(12):6176. doi: 10.3390/ijerph20126176. 77. Yamada H, Makino SI, Okunaga I, Miyake T, Yamamoto-Nonaka K, Oliva Trejo JA, Tominaga T, Empitu MA, Kadariswantiningsih IN, Kerever A, Komiya A, Ichikawa T, Arikawa-Hirasawa E, Yanagita M, Asanuma K. Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue. PNAS Nexus. 2024 Jan 8;3(1):pgad433. doi: 10.1093/pnasnexus/pgad433. eCollection 2024 Jan. 78. Farshadyeganeh P, Yamada T, Ohashi H, Nishimura G, Fujita H, Oishi Y, Nunode M, Ishikawa S, Murotsuki J, Yamashita Y, Ikegawa S, Ogi T, Arikawa-Hirasawa E, Ohno K. Dyssegmental dysplasia Rolland-Desbuquois type is caused by pathogenic variants in HSPG2 - a founder haplotype shared in five patients. J Hum Genet. 2024 Jun;69(6):235-244. doi: 10.1038/s10038-024-01229-6. 79. Kato K, Nishimura H, Suzuki Y, Tanaka T, Abe R, Kerever A, Arikawa-Hirasawa E. Juntendo Iji Zasshi. 2023 Jun 22;69(4):300-306. Oligodendrocyte Cell Line OLP6 Successfully Differentiates on Decellularized Brain Tissue. doi: 10.14789/jmj.JMJ23-0007-OA.

研究テーマ

神経筋疾患における細胞外マトリックスの研究

研究業績（論文）

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著書
1.Arikawa-Hirasawa E. Role of perlecan in developmentand disease. Extracellular Matrix in Development and Disease edited by Jeffrey Miner, Elsevir Advances in Developmental Biology and Biochemistry, volume 15　p65-80 2005
2.Annual Review 神経　2004 分担執筆　p286-292中外医学社XIV. 筋疾患　Schwartz-Jampel症候群（軟骨異栄養性筋強直症）とパールカン
原著論文
1 Sunohara N, Arahata K, Hoffman EP, Yamada H, Nishimiya J, Arikawa E. Kaido M, Nonaka I, and Sugita H：Quadriceps myopathy:form fruste of Becker muscular dystrophy. Annals of Neurology, 28:634-639,1990.

2 ○Arikawa E,Ishihara T, Nonaka I, Sugita H, and Arahata K：Immunocytochemical analysis of dystrophin in congenital muscular dystrophy. Journal of the Neurological Science, 105:79-87,1991.

3 ○Arikawa E, Hoffman EP, Kaido M, Nonaka I, and Arahata K:The requency of patients with dystrophin abnormalities in a limb-girdle patient population. Neurology, 41:1491-1496, 1991.

4 Arahata K, Beggs AH, Honda H, Ito S, Ishiura S, Tsukahara T, Ishiguro T, Eguchi C, Orimo S, Arikawa E, Kaido M, Nonaka I, Sugita H, and Kunkel LM: Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy. Journal of the Neurological Sciences, 101:148-156,1991.

5 Beggs AH, Neumann E, Arahata K, Arikawa E. Nonaka I, Anderson MS, and Kunkel LM: Possible influences on the expression of X chromosome linked dystrophin abnormalities by heterozygosity for autosomal recessive Fukuyama congenital muscular dystrophy. Proc. Natl. Acad. Sci. U.S.A., 89:6623-6627,1992.

6 Udd B, Rapola J, Arikawa E, and Somer H: Nonvacuolar myopathy in a large family with both late adult onset distal myopathy and severe proximal muscular dystrophy. Journal of the Neurological Sciences, 113:214-221,1992.

7 Hoffman EP, Arahata K, Minetti C, Bonilla E, Rowland LP, and Co-Authors：Dystrophinopathy in isolated cases of myopathy in females． Neurology 42;967-975,1992

8 Hayashi YK, Engvall E, Arikawa-Hirasawa E, Goto K, Koga R, Nonaka I, Sugita H, and Arahata K: Abnormal localization of laminin subunits in muscular dystrophies. Journal of the Neurological Sciences,19:53-61,1993.

9 ○Arikawa-Hirasawa E, Koga R, Tsukahara T, Nonaka I, Mitsudome A, Goto K, Beggs AH, and Arahata K: A severe muscular dystrophy patient with an internally deleted very short (110 kD) dystrophin: presence of the binding site for dystrophin-associated glycoprotein (DAG) may not be enough for physiological function of dystrophin．Neuromusclar Disorders, 5:429-438,1995

10 Yamanouchi Y, Arikawa E, Arahata K, Ozawa E, and Nonaka I. Limb-girdle muscular dystrophy: Clinical and pathologic reevaluation, Journal of the Neurological Sciences, 129:15-20,1995.

11 Tumaki N, Tanaka K, Arikawa-Hirasawa E, Nakase T, Kimura T, Thomas JT, Ochi T, Luyten FP, and Yamada Y: Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation. Journal of Cell Biology,144:161-173,1999

12 ○Arikawa-Hirasawa E, Watanabe H, Takami H, Hassell JR, and Yamada Y: Perlecan is essential for cartilage and cephalic development. Nature Genetics, 23:354-358,1999.

13 Fleischmajer R, Kuroda K, Utani A, Douglas MacDonald E, Perlish JS, Arikawa-Hirasawa E, Sekiguchi K, Sanzen N, Timpl R, and Yamada Y: Differential expression of laminin alpha chains during proliferative and differentiation stages in a model for skin morphogenesis. Matrix Biology,19:637-647,2000.

14 ○Arikawa-Hirasawa E, Wilcox RL, Govindraj P, Hassell JR, Yamada Y: Dyssegmental dysplasia, Silverman-Handmaker type, is caused by a functional null mutation of perlecan. Nature Genetics, 27: 431-434. 2001

15 ○Arikawa-Hirasawa E and Yamada Y. Perlecan mutations in mice and humans: critical role of perlecan in skeletal development and disease. Acta Myologica, 20:134-137. 2001

16 ○Arikawa-Hirasawa E, Le AH , Nishino I, Nonaka I, Ho NC , Francomano CA, Govindraj P, Hassell JR, Devaney JM , Spranger J, Stevenson RH, Iannaccone S, Dalakas MC, and Yamada Y. Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia. Am. J. Hum. Gen., 70:1368-1375 2001

17 ○Arikawa-Hirasawa E, Rossi SG, Rotundo RL, and Yamada Y. Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice. Nature Neuroscience, 5:119-123, 2002.

18 Yuasa K, Fukumoto S, Kamasaki Y, Yamada A, Fukumoto E, Kanaoka K, Saito K, Harada H, Arikawa-Hirasawa E, Miyagoe-Suzuki Y, Takeda S, Okamoto K, Kato Y, Fujiwara T. Laminin alpha2 essential for odontoblast differentiation regulating dentin sialoprotein expression. 279(11):10286-92. J Biol Chem. 2004

19 Vikramadithyan RK, Kako Y, Chen G, Hu Y, Arikawa-Hirasawa E, Yamada Y, Goldberg IJ. Atherosclerosis in perlecan heterozygous mice. J Lipid Res. Oct;45(10):1806-12.2004

20 Ichikawa N, Kasai S, Suzuki N, Nishi N, Oishi S, Fujii N, Kadoya Y, Hatori,K Mizuno Y, Nomizu M, and Arikawa-Hirasawa E Identification of neurite outgrowth active sites on the laminin alpha4 chain G domain. Biochemistry ;44(15):5755-5762. ;2005

21 Sugie K, Noguchi S, Kozuka Y, Arikawa-Hirasawa E, Tanaka M, Yan C, Saftig P, von Figura K, Hirano M, Ueno S, Nonaka I, Nishino I. Autophagic Vacuoles with Sarcolemmal Features Delineate Danon Disease and Related Myopathies. J Neuropathol Exp Neurol　Vol. 64, No. 6 pp. 513–522,2005

22 Sher, I., Zisman-Rozen, S., Eliahu L, Whitelock JM, Maas-Szabowski N, Yamada Y, Breitkreutz D, Fusenig NE, Arikawa-Hirasawa E, Iozzo RV, Bergman R, Ron D. Targeting perlecan in human keratinocytes reveals novel roles for perlecan in epidermal formation. J. Biol. Chem., Vol. 281, (8), 5178-5187, February 24, 2006

23 Kerever A, Schnack J, Vellinga D, Ichikawa N, Moon C, Arikawa-Hirasawa E, Efird JT Mercier F. Novel Extracellular Matrix Structures in the Neural Stem Cell Niche Capture the Neurogenic Factor FGF-2 from the Extracellular Milieu Stem Cells Sep ;25(9):2146-57. 2007

24 Awamura Y, Uchida K, Arikawa-Hirasawa E. Long-term follow-up of laminin alpha2 (merosin)-deficient muscular dystrophy in a cat 　J Feline Med Surg. 10, 274-279, 2008

25 Arimura T, Hayashi YK, Murakami T, Oya Y, Funabe S, Arikawa-Hirasawa E, Hattori N, Nishino I and Kimura A.Mutational analysis of Fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy Circulation Journal Jan;73(1):158-61, 2009

26 Ichikawa N, Iwabuchi K, Kurihara H, Ishii K, Kobayashi ,Sasaki T, Hattori N,Mizuno Y, Hozumi K, Yamada Y, and Arikawa-Hirasawa E. Binding of laminin-1 to GM1 ganglioside in lipid rafts is critical forneurite outgrowth. J Cell Sci. Jan 15;122:289-99, 2009

27 Syu A, Ishiguro H, Inada T, Horiuchi Y, Tanaka S, Ishikawa M, Arai M, Itokawa M, Niizato K, Iritani S, Ozaki N, Takahashi M, Kakita A, Takahashi H, Nawa H, Keino-Masu K, Arikawa-Hirasawa E, Arinami T. Association of the HSPG2 gene with neuroleptic-induced tardive dyskinesia Neuropsychopharmacolog. 2010 Apr;35(5):1155-64. Epub Jan 13. 2010 .

28 Sakamoto Y, Ishijima M, Kaneko H, Kurebayashi N, Ichikawa N, Futami I, Kurosawa H, Arikawa-Hirasawa E Distinct Mechanosensitive Ca2+ Influx Mechanisms in Human Primary Synovial Fibroblasts J Orthop Res. 28:859-864, 2010 Jan 27[Epub ahead of print]

29 Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E, Mochizuki H, Kohsaka S, Uchino S. Pigment epithelium-derived factor up-regulation induced by memantine, an N-methyl-d-aspartate receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells. Neuroscience. 2010 May 5;167(2):372-83. Epub Jan 28. 2010

30 Xu Z, Ichikawa N, Kosaki K, Yamada Y, Sasaki T, Sakai LY Kurosawa H, Hattori N, Arikawa-Hirasawa E. Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition Matrix Biol. 2010 Jul;29(6):461-70. Jun 9. [Epub ahead of print] 2010

31 Sasaki T, Takagi J, Giudici C, Yamada Y, Arikawa-Hirasawa E, Deutzmann R, Timpl R, Sonnenberg A, Bächinger HP, Tonge D.Laminin-121-Recombinant expression and interactions with integrins. Matrix Biol. 2010 Jul;29(6):484-93.

32 Ning L, Ishijima M, Kaneko H, Kurihara H, Arikawa-Hirasawa E, Kubota M, Liu L, Xu Z, Futami I, Yusup A, Miyahara K, Xu S, Kaneko K, Kurosawa H, Correlations between both the expression levels of inflammatory mediators and growth factor in medial perimeniscal synovial tissue and the severity of medial knee osteoarthritis, Int. Orthop.2011 Jun;35(6):831-8. Epub 2010Jun 2, 2010 [Epub ahead of print]

33 Chyba M, Mercier F, RaderJ, Douet V Arikawa-Hirasawa E, Kwon YC, Kodama R Dynamic mathematical modeling of cell-fractone interactions　 Journal of Math-for-Industry, Vol. 3 (2011A-8), pp. 79–88

34 Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai,T, Kohsaka S, Chiba H, Hattori H, Yamada Y, and Arikawa-Hirasawa E.　Laminin a1 is essential for mouse cerebellar development　 Matrix Biol. 31(1)January, Pages 17–28 2012

35 Mercier F, Arikawa-Hirasawa E: Heparan sulfate niche for cell proliferation in the adult brain. Neuroscience Letters 2012 Feb 29;510(2):67-72. doi: 10.1016/j.neulet.2011.12.046. Epub 2011 Dec 31.

36 Yoshinaga H, Sakoda,S Good JM, Takahashi MP, Kubota T, Arikawa-Hirasawa E, Nakata T, Ohno K, Kitamura T, Kobayashi K, and Ohtsuka Y: A novel mutation in SCN4A causes severe myotonia and school-age-onset paralytic episodes. Journal of the Neurological Sciences Apr 15;315(1-2):15-9 2012

37 Inomata T , Ebihara N, Funaki, T Matsuda A, Watanabe Y, Ning L, Xu Z, Murakami A, Arikawa-Hirasawa E: Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure, Invest Ophthalmol Vis Sci.、Mar 9;53(3):1277-84., 2012

38 Ishijima M, Suzuki N, Hozumi K, Matsunobu T, Kosaki K, Kaneko H, Hassell JR, Arikawa-Hirasawa E, Yamada Y Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012 Mar 7. May;31(4):234-45 2012. Epub 2012 Mar 7 Epub ahead of print

39 Suzuki N, Fukushi M, Kosaki K, Doyle AD, de Vega S, Yoshizaki K, Akazawa C, Arikawa-Hirasawa E, Yamada Y Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS..J Neurosci. Aug 22;32(34):11586-99. 2012

40 Futami I, Ishijima M, Kaneko H, Tsuji K, Ichikawa-Tomikawa N, Sadatsuki R, Muneta T, Arikawa-Hirasawa E, Sekiya I, Kaneko K Isolation and Characterization of MultipotentialMesenchymal Cells from the Mouse Synovium. PLoS ONE 7(9): e45517 1-12　2012

41 Douet V, Arikawa-Hirasawa E, Mercier F. Fractone-heparan sulfates mediate BMP-7 inhibition of cell proliferation in the adult subventricular zone. Neurosci Lett. Neurosci Lett. 2012 Oct 24;528(2):120-5. 2012. Epub 2012 Sep 7.

42 Douet V, Arikawa-Hirasawa E, Mercier F Fractone-heparan sulfates mediate FGF-2 stimulation of cell proliferation in the adult subventricular zone. Cell Prolif. 2013 Apr;46(2):137-45.

43 Nakazawa N, Miyahara K, Okawada M, Yamataka A, Suzuki R, Akazawa C, Tomikawa-Ichikawa N, Arikawa-Hirasawa E. Laminin-1 promotes enteric nervous system development in mouse embryo. Pediatr Surg Int. 2013 Nov;29(11):1205-8.

44 Suzuki N, Numakawa T • Joshua Chou J, de Vega, S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi N, Arikawa-Hirasawa E, Yamada Y, Akazawa C. Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling . The FASEB Journal article fj.13-241034. Published online. 2014 Mar;28(3):1386-97. doi: 10.1096/fj.13-241034. Epub 2013 Dec 16.

45 Kerever A Mercier F, Nonaka R, de Vega S, Oda Y, Zalc B, Okada Y, Hattori N, Yamada Y, Arikawa-Hirasawa, Perlecan is required for FGF-2 signaling in the neural stem cell niche. Stem Cell Res. 2013 Dec 28;12(2):492-505.

46 Furuya N, Ikeda SI, Sato S, Soma S, Ezaki J, Trejo JA, Takeda-Ezaki M, Fujimura T, Arikawa-Hirasawa E, Tada N, Komatsu M, Tanaka K, Kominami E, Hattori N, Ueno T. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014 Jan 21;10(4). [Epub ahead of print]

47 de Vega S, Suzuki N, Nonaka R, Sasaki T, Forcinito P, Arikawa-Hirasawa E, Yamada Y. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture. Arch Biochem Biophys. 2014 Jan 27

48 Ning L, Kurihara H, de Vega S,* Ichikawa-Tomikawa n, Xu Z,Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-HirasawA E, Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGFβ pathway The American Journal of Pathology . 2014 Jun;184(6):1683-94

48 Ning L, Kurihara H, de Vega S,* Ichikawa-Tomikawa n, Xu Z,Nonaka R, Kazuno S, Yamada Y, Miner JH, Arikawa-Hirasawa E, Laminin α1 regulates age-related mesangial cell proliferation and mesangial matrix accumulation through the TGFβ pathway The American Journal of Pathology . 2014 Jun;184(6):1683-94.doi: 10.1016/j.ajpath.2014.02.006. Epub 2014 Apr 8

Nonaka R, Iesaki T, de Vega S, Daida H, Okada T, Sasaki T, and Arikawa-Hirasawa E Perlecan deficiency causes endothelial dysfunction by reducing the expression of endothelial nitric oxide synthase. Physiol Rep. 2015 Jan 27;3(1). pii: e12272. doi: 10.14814/phy2.12272. Print 2015 Jan 1.

49 Kerever A, Kamagata K, Yokosawa S, Otake Y, Ochi H, Yamada T, Hori M, Kamiya K, Nishikori A, Aoki S, Arikawa-Hirasawa E. See-through Brains and Diffusion Tensor MRI Clarified Fiber Connections: A Magnetic Resonance in Medical Sciences 14(2):159-62. 2015 doi: 10.2463/mrms.2014-0142. Epub 2015 Mar 31　

50 Iwata S, Ito M, Nakata T, Noguchi Y, Okuno T, Ohkawara B, Masuda A, Goto T, Adachi M, Osaka H, Nonaka R, Arikawa-Hirasawa E, Ohno K. A missense mutation in domain III in HSPG2 in Schwartz–Jampel syndrome compromises secretion of perlecan into the extracellular space　Neuromuscul Disord. Aug;25(8):667-71. doi: 10.1016/j.nmd.2015.05.002. Epub 2015 May 8.　2015

51 Kerever A, Yamada T, Suzuki Y Mercier F, Arikawa-Hirasawa, E Fractone aging in the subventricular zone of the lateral ventricle" J Chem Neuroanat. 2015 Jul-Sep;66-67:52-60. Doi10.1016/j.jchemneu.　2015.06.001. Epub 2015 Jun 14.

52 Ning L, Xu Z, Furuya N, Nonaka R, Yamada Y, Arikawa-Hirasawa E. Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle. Matrix Biol. 2015 Oct;48:263 doi:10.1016/j.matbio.2015.08.002. Epub 2015 Aug 28.5310.1016/j.matbio.2015.08.002.

53 de Vega S, Hozumi K, Suzuki N, Nonaka R, Seo E, Takeda A, Ikeuchi T, Nomizu M, Yamada Y, Arikawa-Hirasawa E.Identification of Peptides Derived from the C-terminal Domain of Fibulin-7 Active for Endothelial Cell Adhesion and Tube Formation Disruption. Biopolymers. 2015 Oct 22. doi: 10.1002/bip.22754.

54 Kamagata K, Kerever A, Yokosawa S, Otake Y, Ochi H, Hori M, Kamiya K, Tsuruta K, Tagawa K, Okazawa H, Aoki S, Arikawa-Hirasawa E. Quantitative Histological Validation of Diffusion Tensor MRI with Two-Photon Microscopy of Cleared Mouse Brain.Magn Reson Med Sci. 2016 Mar 30.

55 Sadatsuki R, Kaneko H, Kinoshita M, Futami I, Nonaka R, Culley KL, Otero M, Hada S, Goldring MB, Yamada Y, Kaneko K, Arikawa-Hirasawa E, Ishijima M.　Perlecan is required for the chondrogenic differentiation of synovial mesenchymal cells through regulation of Sox9 gene expression.J Orthop Res doi: J Orthop Res. 2017 Apr;35(4):837-846. doi: 10.1002/jor.23318.

56 Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E. 　Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche. J Neurochem. 2017 May 26. doi: 10.1111/jnc.14081.

57 Sato K, Kerever A, Kamagata K, Tsuruta K, Irie R, Tagawa K, Okazawa H, Arikawa-Hirasawa E, Nitta N, Aoki I, Aoki S. Understanding microstructure of　he brain by comparison of neurite　orientation dispersion and density　imaging (NODDI) with transparent　mouse brain　 Acta Radiol Open. 2017 Apr 17;6(4):2058460117703816. doi: 10.1177/2058460117703816.

59 Fujiwara N, Nakazawa-Tanaka N, Miyahara K, Arikawa-Hirasawa E, Akazawa C, Yamataka A.Altered expression of laminin alpha1 in aganglionic colon of endothelin receptor-B null mouse model of Hirschsprung's disease. Pediatr Surg Int. 2018Feb;34(2):137-141. Doi 10.1007/s00383-017-4180-6. [Epub ahead of print Oct 5 2017]PMID: 28983681

60 Yamada T, Kerever A, Yoshimura Y, Suzuki Y, Nonaka R, Higashi K, Toida T, Mercier F, Arikawa-Hirasawa E Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche. J Neurochem. 2017 Aug;142(4):534-544. doi: 10.1111/jnc.14081. Epub 2017 Jun 20.

61 Nakazawa-Tanaka N, Fujiwara N, Miyahara K, Nakada S, Arikawa-Hirasawa E, Akazawa C, Urao M, Yamataka A.The effect of laminin-1 on enteric neural crest-derived cell migration in the Hirschsprung's disease mouse model. Pediatr Surg Int. 2018 Apr 10;17(2):138-144 doi: 10.1007/s00383-017-4181-5. [Epub ahead of print] PMID: 29018955

62 Irie R, Kamagata K, Kerever A, Ueda R, Yokosawa S, Otake Y, Ochi H, Yoshizawa H, Hayashi A, Tagawa K, Okazawa H, Takahashi K, Sato K, Hori M, Arikawa-Hirasawa E, Aoki S.The Relationship between Neurite Density Measured with Confocal Microscopy in a Cleared Mouse Brain and Metrics Obtained from Diffusion Tensor and Diffusion Kurtosis Imaging. Magn Reson Med Sci. 2018 Apr 10;17(2):138-144. doi: 10.2463/mrms.mp.2017-0031.

63 Yamashita Y, Nakada S, Yoshihara T, Nara T, Furuya N, Miida T, Hattori N, Arikawa-Hirasawa E. Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep. 2018 May 17;8(1):7766. doi: 10.1038/s41598-018-25635-x. PMID:29773865

64 Ikeuchi T, de Vega S, Forcinito P, Doyle AD, Amaral J, Rodriguez IR, Arikawa-Hirasawa E, Yamada Y. Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity. Sci Rep. 2018 Dec 5;8(1):17654.

65 de Vega S, Kondo A, Suzuki M, Arai H, Jiapaer S, Sabit H, Nakada M, Ikeuchi T, Ishijima M, Arikawa-Hirasawa E, Yamada Y, Okada Y. Fibulin-7 is overexpressed in glioblastomas and modulates glioblastoma neovascularization through interaction with angiopoietin-1. Int J Cancer. 2019 Mar 28. doi: 10.1002/ijc.32306.

66 Yoshimura Y, Ishijima M, Ishibashi M, Liu L, Arikawa-Hirasawa E, Machida S, Naito H, Hamada C, Kominami E. A nationwide observational study of locomotive syndrome in Japan using the ResearchKit: The Locomonitor study J Orthop Sci. 2019 Nov;24(6):1094-1104. doi: 10.1016/j.jos.2019.08.009.

67 Nakamura K, Ikeuchi T, Nara K, Rhodes CS, Zhang P, Chiba Y, Kazuno S, Miura Y, Ago T, Arikawa-Hirasawa E, Mukouyama YS, Yamada Y.Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier J Cell Biol
. 2019 Oct 7;218(10):3506-3525.

68 Nakada S, Yamashita Y, Machida S, Miyagoe-Suzuki Y, Arikawa-Hirasawa E. Perlecan Facilitates Neuronal Nitric Oxide Synthase Delocalization in Denervation-Induced Muscle Atrophy Cells. 2020 Nov 23;9(11):2524. doi:10.3390/cells9112524.doi: 10.1083/jcb.201807178.

69 Kerever A, Nagahara F, Keino-Masu K, Masu M, van Kuppevelt TH, Vivès RR, Arikawa-Hirasawa E.Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches Glycobiology. 2021 Jul 29;cwab081. doi: 10.1093/glycob/cwab081.

70 Nonaka R, Iesaki T, Kerever A, Arikawa-Hirasawa E Increased Risk of Aortic Dissection with Perlecan Deficiency. Int J Mol Sci. 2021 23(1):315.

71 Tsuji Y, Kerever A, Furukawa T, Kamagata K, Saito Y, Aoki S, Hata J, Okano H, Kobayashi K, Okada T, Miya K, Keino-Masu K, Masu M, Arikawa-Hirasawa E Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain. Magn Reson Imaging. 2022 88:123-131

72 Nakada S, Yamashita Y, Akiba S, Shima T, Arikawa-Hirasawa E. Myocyte Culture with Decellularized Skeletal Muscle Sheet with Observable Interaction with the Extracellular Matrix. Bioengineering (Basel). 12;9(7):309. 2022 doi: 10.3390/bioengineering9070309.

73 Arikawa-Hirasawa E Impact of the heparan sulfate proteoglycan perlecan on human disease and health. Am J Physiol Cell Physiol
. 2022 Jun 1;322(6):C1117-C1122. doi: 10.1152/ajpcell.00113.2022

74 Hayashiji N, Kawahara G, Xu X, Fukuda T, Kerever A, Gu J, Hayashi YK, Arikawa-Hirasawa E. α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish. Cells. 2022 Dec 29;12(1):144.doi: 10.3390/cells12010144.

75 Yamashita Y, Nakada S, Nakamura K, Sakurai H, Ohno K, Goto T, Mabuchi Y, Akazawa C, Hattori N, Arikawa-Hirasawa E. Evaluation of Human-Induced Pluripotent Stem Cells Derived from a Patient with Schwartz-Jampel Syndrome Revealed Distinct Hyperexcitability in the Skeletal MusclesBiomedicines. 2023 Mar 7;11(3):814. doi: 10.3390/biomedicines11030814.

76. Kanazawa A, Fujibayashi K, Watanabe Y, Kushiro S, Yanagisawa N, Fukataki Y, Kitamura S, Hayashi W, Nagao M, Nishizaki Y, Inomata T, Arikawa-Hirasawa E, Naito T.
Evaluation of a Medical Interview-Assistance System Using Artificial Intelligence for Resident Physicians Interviewing Simulated Patients: A Crossover, Randomized, Controlled Trial.
Int J Environ Res Public Health. 2023 Jun 19;20(12):6176. doi: 10.3390/ijerph20126176.

77. Yamada H, Makino SI, Okunaga I, Miyake T, Yamamoto-Nonaka K, Oliva Trejo JA, Tominaga T, Empitu MA, Kadariswantiningsih IN, Kerever A, Komiya A, Ichikawa T, Arikawa-Hirasawa E, Yanagita M, Asanuma K. Beyond 2D: A scalable and highly sensitive method for a comprehensive 3D analysis of kidney biopsy tissue. PNAS Nexus. 2024 Jan 8;3(1):pgad433. doi: 10.1093/pnasnexus/pgad433. eCollection 2024 Jan.

78. Farshadyeganeh P, Yamada T, Ohashi H, Nishimura G, Fujita H, Oishi Y, Nunode M, Ishikawa S, Murotsuki J, Yamashita Y, Ikegawa S, Ogi T, Arikawa-Hirasawa E, Ohno K. Dyssegmental dysplasia Rolland-Desbuquois type is caused by pathogenic variants in HSPG2 - a founder haplotype shared in five patients. J Hum Genet. 2024 Jun;69(6):235-244. doi: 10.1038/s10038-024-01229-6.

79. Kato K, Nishimura H, Suzuki Y, Tanaka T, Abe R, Kerever A, Arikawa-Hirasawa E.
Juntendo Iji Zasshi. 2023 Jun 22;69(4):300-306. Oligodendrocyte Cell Line OLP6 Successfully Differentiates on Decellularized Brain Tissue. doi: 10.14789/jmj.JMJ23-0007-OA.

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