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服部浩一（ハットリコウイチ）

研究テーマ	炎症・腫瘍増殖及び組織再生機構と各種疾患病態の解明及び治療法の開発
研究業績（論文）	1.Skrypnyk R, Skrypnyk M, Skikevych M, Skrypnyk I, Yatsenko T, Petrushanko T, Spahr A, Xu C, Takahashi S, Osada T, Berkovsky S, Hattori K and Heissig B. Salivary Gland Manifestations of Long COVID: A Case Report and Literature Review. Healthcare. 14(16): 2558, (2026) doi: 10.3390/healthcare14162558 2.Yano S, Osada T, Ogiwara S, Furihata M, Hattori K, Heissig B, Nomura O, Shibuya T, Nagahara A. Predicting Clinical Response to Granulocyte/Monocyte Adsorption Apheresis in Treatment-resistant Ulcerative Colitis. Gastro Hep Adv. 5: 100922 (2026) doi: 10.1016/j.gastha.2026.100922 3.Skrypnyk M, Spahr A, Berkovsky S, Yatsenko T, Xu C, Zuieva O, Osada T, Takahashi S, Hattori N, Takahashi K, Hattori K and Heissig B. Chronic Stress and the IL-10-Mediated Immunoregulatory Loop in the Pathogenesis of Periodontitis. Clin Sci (Lond). 139: 1469-1487 (2025) doi: 10.1042/CS20256843. 4.Skrypnyk M, Yatsenko T, Riabets O, Zuieva O, Salama Y, Rodionova I, Skikevych M, Salama Y, Osada T, Tobita M, Takahashi S, Hattori N, Takahashi K, Hattori K and Heissig B. Potassium Iodide Induces Apoptosis in Salivary Gland Cancer Cells. Int J Mol Sci. 26: 5199 (2025) doi: 10.3390/ijms26115199 5.Salama Y, Munakata S, Osada T, Takahashi S and Hattori K and Heissig B. Heparin-binding EGF-Like Growth Factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers. Cell Death Dis.15: 753. (2024) doi: 10.1038/s41419-024-07126-2 6.YatsenkoT, Rios R, Rios T, Salama Y, Takahashi S, Adachi E, Tabe Y, Hattori N, Osada T, Naito T, Takahashi K, Hattori K and Heissig B. The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction. Frontier Immunol. 15: 1445294. (2024) doi: 10.3389/fimmu.2024.1445294 7.Skrypnyk M, Yatsenko T, Riabets O, Salama Y, Skikevych M, Osada T, Tobita M, Takahashi S, Hattori K and Heissig B. Interleukin-10 induces TNF-α-driven apoptosis ROS production in salivary glands cancer cells. Heliyon. 10: E31777. (2024) doi: https://doi.org/10.1016/j.heliyon.2024.e31777 8.Yatsenko T, Rios R, Rios T, Salama Y, Takahashi S, Tabe Y, Naito T, Takahashi T, Hattori K and Heissig B. Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19. Frontier Immunol. 14: 1299792. (2024) doi: 10.3389/fimmu.2023.1299792 9.Mizoue Y, Ikeda T, Ikegami T, Riabets O, Oishi Y, Tobita M, Akutsu H, Hattori K, Heissig B and Koide H. The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells.Int J Dev Biol. 67: 147 - 153 (2023) doi: 10.1387/ijdb.230143hk 10.Yatsenko T, Skrypnyk M, Toroyanovska O, Tobita M, Osada T, Takahashi S, Hattori K, and Heissig B. The role of plasminogen/plasmin system in inflammation of oral cavity. Cells 12(3), 445; (2023) doi: 10.3390/cells12030445 11.Salama Y, Takahashi S, Tsuda Y, Okada Y, Hattori K, and Heissig B. YO2 induces melanoma cell apoptosis through p53-mediated LRP1 downregulation. Cancers(Basel). 15(1), 288; (2022) doi: 10.3390/cancers15010288 12.Heissig B, Salama Y, Iakoubov R, Vehreschild JJ, Rios R, Nogueira T, Vehreschild MJGT, Stecher M, Mori H, Lanznaster J, Adachi E, Jakob C, Tabe Y, Ruethrich M, Borgmann S, Naito T, Wille K, Valenti S, Hower M, Hattori N, Rieg S, Nagaoka T, Jensen BE, Yotsuyanagi H, Hertenstein B, Ogawa H, Wyen C, Kominami E, Roemmele C, Takahashi S, Rupp J, Takahashi K, Hanses F, Hattori K and on behalf of the LEOSS study group. COVID-19 severity and thrombo-inflammatory response linked to ethnicity. Biomedicines. 10(10), 2549; (2022) doi: 10.3390/biomedicines10102549 13.Heissig B, Salama Y, Tateno M, Takahashi S and Hattori K. siRNA against CD40 delivered via a fungal recognition receptor ameliorates murine acute graft-versus-host disease. EJHaem. 3(3): 849-861, (2022) doi: 10.1002/jha2.439. eCollection 2022 Aug 14.Salama Y, Shiou-Yuh Lin, Dhahri D, Hattori K, and Heissig B. Aloysia citrodora essential oil inhibits melanoma cell growth and migration by targeting HB-EGF-EGFR signaling. Int J Mol Sci. in press (2022) 15.Heissig B, Salama Y, Takahashi S, Okumura K and Hattori K. The multifaceted role of EGFL7 in cancer and drug resistance Cancers(Basel). 13:1014 (2021) doi: 10.3390/cancers13051014. 16.Heissig B, Salama Y, Takahashi S, Okumura K and Hattori K. The multifaceted role of EGFL7 in cancer and drug resistance Cancers(Basel).13:1014; doi: 10.3390/cancers13051014 (2021) doi: 10.3390/cancers13051014 17.Heissig B, Salama Y, Takahashi S, Osada T Okumura K and Hattori K. The multifaceted role of plasminogen in cancer Int J Mol Sci. 22:2304 (2021) doi: 10.3390/ijms22052304 doi: 10.3390/ijms22052304 18.Heissig B, Salama Y, Shimazu H, Takahashi S, Osada T and Hattori K. The multifaceted role of plasminogen in cancer and inflammation Cell Signal. 75:109761 (2020) doi:10.1016/j.cellsig.2020.109761. 19.Heissig B, Salama Y, Takahashi S, Osada T Okumura K and Hattori K. The multifaceted role of plasminogen in cancer Int J Mol Sci. 22:2304 (2021) doi: 10.3390/ijms22052304. 20.Heissig B, Salama Y, Shimazu H, Takahashi S, Osada T and Hattori K. The multifaceted role of plasminogen in cancer and inflammation Cell Signal. 75:109761 (2020) doi:10.1016/j.cellsig.2020.109761. 21.Sato-Okabayashi Y, Isoda K, Heissig B, Kadoguchi T, Akita K, Kitamura K, Shimada K, Hattori K and Daida H. Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression decreasing inflammatory cells in a murine model of atherosclerosis by decreasing inflammatory cells in a murine model of atherosclerosis. IJC Heart Vasc. 20:100529 (2020) 22.Salama Y, Andries H, Yokoyama K, Takahashi S, Hattori K and Heissig B The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models. Blood Adv. 24: 1021-1037, (2020) 23.Heissig B, Salama Y, Shimazu H, Takahashi S, Osada T and Hattori K. The multifaceted role of plasminogen in cancer and inflammation Cell Signal. 75:109761 (2020) 24.Salama Y, Shiou-Yuh Lin, Dhahri D, Hattori K, and Heissig B. The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis. FASEB J. 33: 3465-3480, (2019) 25.Salama Y, Hattori K, and Heissig B. The angiogenic factor Egfl7 alters thymogenesis by activating Flt3 signaling. Biochem Biophys Res Commun. 490: 209-216, (2017) 26.Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonsert S, Ohta Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K. Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome. Blood. 130: 59-72, (2017) 27.Eiamboonsert S, Salama Y, Watarai H, Dhahri D, Tsuda Y, Okada Y, Hattori K, and Heissig B. The role of plasmin in the pathogenesis of murine multiple myeloma. Biochem Biophys Res Commun. 488: 387-392, (2017) 28.Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Dhahri D, Eiamboonser S, Ichimura A, Dan T, Myata T, Takeda K, Sakamoto K, Hattori K and Heissig B. Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice. FASEB J. 31: 2625-2637, (2017) 29.Heissig B, Eiamboonsert S, Salama Y, Shimazu H, Dhahri D, Munakata S Tashiro Y and Hattori K. Cancer therapy targeting the fibrinolytic system Advanced Drug Delivery Rev 99: 172-179, (2016) 30.Heissig B, Eiamboonsert S, Salama Y, Shimazu H, Dhahri D, Munakata S Tashiro Y and Hattori K. Cancer therapy targeting the fibrinolytic system Advanced Drug Delivery Rev. 99: 172-179 (2016) 10.1016/j.addr.2015.11.010 31.Heissig B, Dhahri D, Eiamboonsert S, Salama Y, Shimazu H, Munakata S and Hattori K. Role of mesenchymal stem cell-derived factor in tissue regeneration and cancer progression Cell Mol Life Sci. 72: 4759-4770, (2015) doi: 10.1007/s00018-015-2035-7 32.Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonser S, Nakauchi H, Hattori K and Heissig B. The fibrinolytic pathway expands the murine bone marrow mesenchymal stem/stromal cells through a crosstalk with endothelial cells. Blood. 128: 1063-1075, (2016) 33.Heissig B, Dhahri D, Eiamboonsert S, Salama Y, Shimazu H, Munakata S and Hattori K. Role of mesenchymal stem cell-derived factor in tissue regeneration and cancer progression Cell Mol Life Sci 72: 4759-4770, (2015) 34.Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonser S,Takeda K,Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, and Hattori K. Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase-9-mediated cytokine release from myeloid cells. Gastroenterology.148：565-578 (2015) 35.Sato A,Nishida C,Sato-Kusubata K,Ishihara M,Tashiro Y,Gritli I,Shimazu H, Munakata S,Yagita H,Okumura K,Tsuda Y,Okada Y,Tojyo A,Nakauchi H, Takahashi S,Heissig B and Hattori K. Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking. Leukemia. 29: 145-156, (2015) 36.Nakahara F, Kitaura J, Nishida C, Uchida T, Togami K, Inoue D, Matsukawa T, Enomoto Y, Kawabata CK, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Hattori K and Kitamura T. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP9 up-regulation in leukemic cells. Blood. 123(25)3932-42 .(2014) 37.Caiado F, Carvalho T, Rosa I, Remedio L, Costa A, Matos J, Heissig B, Yagita H, Hattori K, da Silva JP, Fidalgo P, Dias Pereira A and Dias S. Bonemarrow-derived CD11b+ Jagged-2+ cells promote epithelial to mesenchymal transition and metastization in colorectal cancer. Cancer Res. 73, 4233-46 (2013)　 38.Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, and Hattori K. MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells. Blood.119, 5405-5416 (2012) 39.Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Tomiki Y, Sakamoto H, Dan T, Miyata T, Okumura K, Nakauchi H, Heissig B, and Hattori K. Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice. Blood.l19, 6382-6393 ( 2012 ) 40.Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Heissig B and Hattori K. Plasminogen deficiency attenuates post-natal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis. Exp Hematol, 40,143-154 (2012) 41.Ishihara M, Nishida C, Tashiro Y, Gritli I, Rosenkvist J, Koizumi M, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K. Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b+/F4/80+ myeloid cell recruitment .Leukemia. 26, 332-339 (2012) 42.Heissig B, Ohki-Koizumi M, Tashiro Y, Gritli I, Sato-Kusubata K and Hattori K. New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis Int J Hematol. 95, 131-137 (2012) 43.Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N and Nakano H. Tumor necrosis receptor-associated factor (Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease. J Biol Chem, 151, 17879-17888 (2011) doi: 10.1074/jbc.M111.221853

研究テーマ

炎症・腫瘍増殖及び組織再生機構と各種疾患病態の解明及び治療法の開発

研究業績（論文）

1.Skrypnyk R, Skrypnyk M, Skikevych M, Skrypnyk I, Yatsenko T, Petrushanko T, Spahr A, Xu C, Takahashi S, Osada T, Berkovsky S, Hattori K and Heissig B. Salivary Gland Manifestations of Long COVID: A Case Report and
Literature Review. Healthcare. 14(16): 2558, (2026) doi: 10.3390/healthcare14162558

2.Yano S, Osada T, Ogiwara S, Furihata M, Hattori K, Heissig B, Nomura O, Shibuya T, Nagahara A. Predicting Clinical Response to Granulocyte/Monocyte Adsorption Apheresis in Treatment-resistant Ulcerative Colitis. Gastro Hep Adv. 5: 100922 (2026) doi: 10.1016/j.gastha.2026.100922

3.Skrypnyk M, Spahr A, Berkovsky S, Yatsenko T, Xu C, Zuieva O, Osada T, Takahashi S, Hattori N, Takahashi K, Hattori K and Heissig B. Chronic Stress and the IL-10-Mediated Immunoregulatory Loop in the Pathogenesis of Periodontitis. Clin Sci (Lond). 139: 1469-1487 (2025) doi: 10.1042/CS20256843.

4.Skrypnyk M, Yatsenko T, Riabets O, Zuieva O, Salama Y, Rodionova I, Skikevych M, Salama Y, Osada T, Tobita M, Takahashi S, Hattori N, Takahashi K, Hattori K and Heissig B. Potassium Iodide Induces Apoptosis in Salivary Gland Cancer Cells. Int J Mol Sci. 26: 5199 (2025) doi: 10.3390/ijms26115199

5.Salama Y, Munakata S, Osada T, Takahashi S and Hattori K and Heissig B. Heparin-binding EGF-Like Growth Factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers. Cell Death Dis.15: 753. (2024) doi: 10.1038/s41419-024-07126-2

6.YatsenkoT, Rios R, Rios T, Salama Y, Takahashi S, Adachi E, Tabe Y, Hattori N, Osada T, Naito T, Takahashi K, Hattori K and Heissig B. The influence of 4G/5G polymorphism in the plasminogen-activator-inhibitor-1 promoter on COVID-19 severity and endothelial dysfunction. Frontier Immunol. 15: 1445294. (2024) doi: 10.3389/fimmu.2024.1445294

7.Skrypnyk M, Yatsenko T, Riabets O, Salama Y, Skikevych M, Osada T, Tobita M, Takahashi S, Hattori K and Heissig B. Interleukin-10 induces TNF-α-driven apoptosis ROS production in salivary glands cancer cells. Heliyon. 10: E31777. (2024) doi: https://doi.org/10.1016/j.heliyon.2024.e31777

8.Yatsenko T, Rios R, Rios T, Salama Y, Takahashi S, Tabe Y, Naito T, Takahashi T, Hattori K and Heissig B. Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19. Frontier Immunol. 14: 1299792. (2024) doi: 10.3389/fimmu.2023.1299792

9.Mizoue Y, Ikeda T, Ikegami T, Riabets O, Oishi Y, Tobita M, Akutsu H, Hattori K, Heissig B and Koide H. The stem cell transcription factor ZFP296 transforms NIH3T3 cells and promotes anchorage-independent growth of cancer cells.Int J Dev Biol. 67: 147 - 153 (2023) doi: 10.1387/ijdb.230143hk

10.Yatsenko T, Skrypnyk M, Toroyanovska O, Tobita M, Osada T, Takahashi S, Hattori K, and Heissig B. The role of plasminogen/plasmin system in inflammation of oral cavity. Cells 12(3), 445; (2023) doi: 10.3390/cells12030445

11.Salama Y, Takahashi S, Tsuda Y, Okada Y, Hattori K, and Heissig B. YO2 induces melanoma cell apoptosis through p53-mediated LRP1 downregulation. Cancers(Basel). 15(1), 288; (2022) doi: 10.3390/cancers15010288

12.Heissig B, Salama Y, Iakoubov R, Vehreschild JJ, Rios R, Nogueira T, Vehreschild MJGT, Stecher M, Mori H, Lanznaster J, Adachi E, Jakob C, Tabe Y, Ruethrich M, Borgmann S, Naito T, Wille K, Valenti S, Hower M, Hattori N, Rieg S, Nagaoka T, Jensen BE, Yotsuyanagi H, Hertenstein B, Ogawa H, Wyen C, Kominami E, Roemmele C, Takahashi S, Rupp J, Takahashi K, Hanses F, Hattori K and on behalf of the LEOSS study group. COVID-19 severity and thrombo-inflammatory response linked to ethnicity. Biomedicines. 10(10), 2549; (2022) doi: 10.3390/biomedicines10102549

13.Heissig B, Salama Y, Tateno M, Takahashi S and Hattori K. siRNA against CD40 delivered via a fungal recognition receptor ameliorates murine acute graft-versus-host disease. EJHaem. 3(3): 849-861, (2022) doi: 10.1002/jha2.439. eCollection 2022 Aug

14.Salama Y, Shiou-Yuh Lin, Dhahri D, Hattori K, and Heissig B. Aloysia citrodora essential oil inhibits melanoma cell growth and migration by targeting HB-EGF-EGFR signaling. Int J Mol Sci. in press (2022)

15.Heissig B, Salama Y, Takahashi S, Okumura K and Hattori K. The multifaceted role of EGFL7 in cancer and drug resistance Cancers(Basel). 13:1014 (2021) doi: 10.3390/cancers13051014.

16.Heissig B, Salama Y, Takahashi S, Okumura K and Hattori K. The multifaceted role of EGFL7 in cancer and drug resistance Cancers(Basel).13:1014; doi: 10.3390/cancers13051014 (2021) doi: 10.3390/cancers13051014

17.Heissig B, Salama Y, Takahashi S, Osada T Okumura K and Hattori K. The multifaceted role of plasminogen in cancer Int J Mol Sci. 22:2304 (2021) doi: 10.3390/ijms22052304 doi: 10.3390/ijms22052304

18.Heissig B, Salama Y, Shimazu H, Takahashi S, Osada T and Hattori K. The multifaceted role of plasminogen in cancer and inflammation Cell Signal. 75:109761 (2020) doi:10.1016/j.cellsig.2020.109761.

19.Heissig B, Salama Y, Takahashi S, Osada T Okumura K and Hattori K. The multifaceted role of plasminogen in cancer Int J Mol Sci. 22:2304 (2021) doi: 10.3390/ijms22052304.

20.Heissig B, Salama Y, Shimazu H, Takahashi S, Osada T and Hattori K. The multifaceted role of plasminogen in cancer and inflammation Cell Signal. 75:109761 (2020) doi:10.1016/j.cellsig.2020.109761.

21.Sato-Okabayashi Y, Isoda K, Heissig B, Kadoguchi T, Akita K, Kitamura K, Shimada K, Hattori K and Daida H. Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression decreasing inflammatory cells in a murine model of atherosclerosis by decreasing inflammatory cells in a murine model of atherosclerosis. IJC Heart Vasc. 20:100529 (2020)

22.Salama Y, Andries H, Yokoyama K, Takahashi S, Hattori K and Heissig B The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models. Blood Adv. 24: 1021-1037, (2020)

23.Heissig B, Salama Y, Shimazu H, Takahashi S, Osada T and Hattori K. The multifaceted role of plasminogen in cancer and inflammation Cell Signal. 75:109761 (2020)

24.Salama Y, Shiou-Yuh Lin, Dhahri D, Hattori K, and Heissig B. The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis. FASEB J. 33: 3465-3480, (2019)

25.Salama Y, Hattori K, and Heissig B. The angiogenic factor Egfl7 alters thymogenesis by activating Flt3 signaling. Biochem Biophys Res Commun. 490: 209-216, (2017)

26.Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonsert S, Ohta Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K. Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome. Blood. 130: 59-72, (2017)

27.Eiamboonsert S, Salama Y, Watarai H, Dhahri D, Tsuda Y, Okada Y, Hattori K, and Heissig B. The role of plasmin in the pathogenesis of murine multiple myeloma. Biochem Biophys Res Commun. 488: 387-392, (2017)

28.Honjo K, Munakata S, Tashiro Y, Salama Y, Shimazu H, Dhahri D, Eiamboonser S, Ichimura A, Dan T, Myata T, Takeda K, Sakamoto K, Hattori K and Heissig B. Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice. FASEB J. 31: 2625-2637, (2017)

29.Heissig B, Eiamboonsert S, Salama Y, Shimazu H, Dhahri D, Munakata S Tashiro Y and Hattori K. Cancer therapy targeting the fibrinolytic system Advanced Drug Delivery Rev 99: 172-179, (2016)

30.Heissig B, Eiamboonsert S, Salama Y, Shimazu H, Dhahri D, Munakata S Tashiro Y and Hattori K. Cancer therapy targeting the fibrinolytic system Advanced Drug Delivery Rev. 99: 172-179 (2016) 10.1016/j.addr.2015.11.010

31.Heissig B, Dhahri D, Eiamboonsert S, Salama Y, Shimazu H, Munakata S and Hattori K. Role of mesenchymal stem cell-derived factor in tissue regeneration and cancer progression Cell Mol Life Sci. 72: 4759-4770, (2015) doi: 10.1007/s00018-015-2035-7

32.Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonser S, Nakauchi H, Hattori K and Heissig B. The fibrinolytic pathway expands the murine bone marrow mesenchymal stem/stromal cells through a crosstalk with endothelial cells. Blood. 128: 1063-1075, (2016)

33.Heissig B, Dhahri D, Eiamboonsert S, Salama Y, Shimazu H, Munakata S and Hattori K. Role of mesenchymal stem cell-derived factor in tissue regeneration and cancer progression Cell Mol Life Sci 72: 4759-4770, (2015)

34.Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonser S,Takeda K,Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, and Hattori K. Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase-9-mediated cytokine release from myeloid cells. Gastroenterology.148：565-578 (2015)

35.Sato A,Nishida C,Sato-Kusubata K,Ishihara M,Tashiro Y,Gritli I,Shimazu H, Munakata S,Yagita H,Okumura K,Tsuda Y,Okada Y,Tojyo A,Nakauchi H, Takahashi S,Heissig B and Hattori K. Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking. Leukemia. 29: 145-156, (2015)

36.Nakahara F, Kitaura J, Nishida C, Uchida T, Togami K, Inoue D, Matsukawa T, Enomoto Y, Kawabata CK, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Hattori K and Kitamura T. Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP9 up-regulation in leukemic cells. Blood. 123(25)3932-42 .(2014)

37.Caiado F, Carvalho T, Rosa I, Remedio L, Costa A, Matos J, Heissig B, Yagita H, Hattori K, da Silva JP, Fidalgo P, Dias Pereira A and Dias S. Bonemarrow-derived CD11b+ Jagged-2+ cells promote epithelial to mesenchymal transition and metastization in colorectal cancer. Cancer Res. 73, 4233-46 (2013)　

38.Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, and Hattori K. MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells. Blood.119, 5405-5416 (2012)

39.Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Tomiki Y, Sakamoto H, Dan T, Miyata T, Okumura K, Nakauchi H, Heissig B, and Hattori K. Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice. Blood.l19, 6382-6393 ( 2012 )

40.Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Heissig B and Hattori K. Plasminogen deficiency attenuates post-natal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis. Exp Hematol, 40,143-154 (2012)

41.Ishihara M, Nishida C, Tashiro Y, Gritli I, Rosenkvist J, Koizumi M, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Heissig B and Hattori K. Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b+/F4/80+ myeloid cell recruitment .Leukemia. 26, 332-339 (2012)

42.Heissig B, Ohki-Koizumi M, Tashiro Y, Gritli I, Sato-Kusubata K and Hattori K. New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis Int J Hematol. 95, 131-137 (2012)

43.Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N and Nakano H. Tumor necrosis receptor-associated factor (Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease. J Biol Chem, 151, 17879-17888 (2011) doi: 10.1074/jbc.M111.221853

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