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研究業績詳細

八尾隆史（ヤオタカシ）

研究テーマ	消化管病理学
研究業績（論文）	1. Morimoto T, Mitomi H, Saito T, Takahashi M, Murakami T, Sakamoto N, Yao T, Watanabe S. Distinct profile of HIF1α, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma. J Gastroenterol Hepatol 29: 1192-1199, 2014. 2. Nomura R, Saito T, Mitomi H, Hidaka Y, Lee S-Y, Watanabe S, Yao T, GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. Hum Pathol 45: 2488-2496, 2014. 3. Saito T, Mitomi H, Imamhasan A, Hayashi T, Mitani K, Takahashi M, Kajiyama Y, Yao T. Downregulation of sFRP-2 by epigenetic silencing activates the β-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. Virchows Arch 464(2):135-43, 2014. 4. Ueyama H, Matsumoto K, Nagahara A, Hayashi T, Yao T, Watanabe S. Gastric adenocarcinoma of the fundic gland type (chief cell predominant type). Endosc 46: 153-157, 2014. 5. Lee S-Y, Saito T, Mitomi H, Hidaka Y, Murakami T, Nomura R, Watanabe S, Yao T. Mutation spectrum in the Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps. Virchow Arch 467:27–38, 2015 6. Murakami T, Mitomi H, Saito T, Takahashi M, Sakamoto N, Fukui N, Yao T, Watanabe S.Distinct WNT/β-catenin signaling activation in the serrated neoplasia pathway and the adenoma-carcinoma sequence of the colorectum. Mod Pathol. 28(1):146-58, 2015. 7. Gushima R, Yao T, Kurisaki-Arakawa A, Hara K, Hayashi T, Fukumura Y, Saito T, Arakawa A, Yao K, Sasaki Y. Expression of adipophilin in gastric epithelial neoplasia is associated with intestinal differentiation and discriminates between adenoma and adenocarcinoma. Virchow Arch 468: 169-177, 2016 8. Murakami T, Yao T, Mitomi H, Morimoto T, Ueyama H, Matsumoto K, Saito T, Osada T, Nagahara A, Watanabe S. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric cancer 19(2):498-507，2016 9. Matsumoto K, Ueyama H, Matsumoto K, Akazawa Y, Komori H, Takeda T, Murakami T, Asaoka D, Hojo M, Tomita N, Nagahara A, Kajiyama Y, Yao T, Watanabe S. Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation. World J Gastroenterol 22(36): 8203-8210, 2016. 10. Tajima Y, Murakami T, Saito T, Hiromoto T, Akazawa Y, Sasahara N, Mitomi H, Yao T, Watanabe S. Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma. Digestion 96(2):81-91, 2017. 11. Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Watanabe S. Epigenetic regulation of Wnt/β-catenin signal-associated genes in gastric neoplasia of the fundic gland (chief cell-predominant) type. Pathol Int 67(3):147-155, 2017. 12. Akazawa Y, Ueyama H, Yao T, Komori H, Takeda T, Matsumoto K, Matsumoto K, Asaoka D, Hojo M, Watanabe S, Nagahara A. Usefulness of Demarcation of Differentiated-Type Early Gastric Cancers after Helicobacter pylori Eradication by Magnifying Endoscopy with Narrow-Band Imaging. Digestion 98(3):175-184, 2018. 13. Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma. Hum Pathol 78:79-88, 2018. 14. He C, Fukumura Y, Toriyama A, Ogura K, Sasahara N, Mitani K, Yao T. Pyloric Gland Adenoma (PGA) of the Gallbladder: A Unique and Distinct Tumor from PGAs of the Stomach, Duodenum, and Pancreas. Am J Surg Pathol 42(9):1237-1245, 2018. 15. Hiromoto T, Murakami T, Akazawa Y, Sasahara N, Saito T, Sakamoto N, Mitomi H, Nagahara A, Yao T. Immunohistochemical and genetic characteristics of a colorectal mucin-rich variant of traditional serrated adenoma. Histopathology 73(3):444-453, 2018. 16. Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Sakamoto N, Osada T, Watanabe S. Distinct histopathological characteristics in colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp and conventional tubular adenoma. Virchows Arch 472(3):383-393, 2018. 17. Raposo TP, Comes MS, Idowu A, Agit B, Hassall J, Fadhil W, Nica R, Ecker R, Yao T, Ilyas M. CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Exp Mol Pathol 104(3):190-198, 2018. 18. Yatagai N, Saito T, Akazawa Y, Hayashi T, Yanai Y, Tsuyama S, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation. Virchows 474: 315-324, 2019. 19. Yamashiro Y, Saito T, Hayashi T, Murakami T, Yanai Y, Tsuyama S, Suehara Y, Takamochi K, Yao T. Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation. Histopathology 77: 492-502, 2020. 20. Ueyama H, Yao T, Akazawa Y, Hayashi T, Kurahara K, Oshiro Y, Yamada M, Oda I, Fujioka S, Kusumoto C, Fukuda M, Uchita K, Kadota T, Oono Y, Okamoto K, Murakami K, Matsuo Y, Kato M, Maehata T, Yahagi N, Yasuhara Y, Yada T, Uraushihara K, Yamane T, Matsuo T, Ito M, Maruyama Y, Osako A, Ono S, Kato M, Yagi K, Hashimoto T, Tomita N, Tsuyama S, Saito T, Matsumoto K, Matsumoto K, Watanabe S, Uemura N, Chiba T, Nagahara A. Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland type. J Gastroenterol 56(9):814-828, 2021. 21. Akazawa Y, Ueyama H, Hayashi T, Utsunomiya H, Uchida R, Abe D, Oki S, Suzuki N, Ikeda A, Yatagai N, Komori H, Takeda T, Matsumoto K, Ueda K, Matsumoto K, Asaoka D, Hojo M, Saito T, Yao T, Nagahara A. Clinicopathological and molecular characterization of early gastric adenocarcinoma in Helicobacter pylori-uninfected patients: emphasis on differentiated gastric adenocarcinoma. J Gastroenterol 57:725-734, 2022. 22. Yanai Y, Hayashi T, Tsuyama S, Nasu M, Hashimoto T, Kajiyama Y, Tsurumaru M, Mine S, Orita H, Fukunaga T, Yao T, Saito T. Clinicopathological and mutational analysis of esophageal basaloid squamous cell carcinoma. Virchows Arch 481:477-487, 2022. 23. Abe D, Akazawa Y, Yatagai N, Hayashi T, Ueyama H, Mine S, Fukunaga T, Nagahara A, Yao T, Saito T. Clinicopathological characteristics of gastric adenocarcinoma with enteroblastic differentiation and gastric adenocarcinoma with enteroblastic marker expression. Virchows Arch 483:405-414, 2023. 24. Haruma K, Kinoshita Y, Yao T, Kushima R, Akiyama J, Aoyama N, Kanoo T, Miyata K, Kusumoto N, Uemura N. Randomised clinical trial: 3-year interim analysis results of the VISION trial to evaluate the long-term safety of vonoprazan as maintenance treatment in patients with erosive oesophagitis. BMC Gastroenterol 23(1):139, 2023. doi: 10.1186/s12876-023-02772-w. 25. Kojima M, Yokota M, Yanagisawa N, Kitamura S, Amemiya K, Kawano S, Tsukada Y, Sakuyama N, Nagayasu K, Hashimoto T, Nakashima K, Jiang K, Kanemitsu Y, Fujita F, Akiba J, Notohara K, Itakura J, Sekine S, Sakashita S, Sakamoto N, Ishikawa S, Nakanishi Y, Yao T, Liang WY, Lauwers GY, Ito M, Sakamoto K, Ishii G, Ochiai A. Assessment of Elastic Laminal Invasion Contributes to an Objective pT3 Subclassification in Colon Cancer. Am J Surg Pathol 47(10):1122-1133, 2023. 26. Namikawa K, Kamada T, Fujisaki J, Sato Y, Murao T, Chiba T, Kaizaki Y, Ishido K, Ihara Y, Kurahara K, Suga T, Suzuki H, Ito M, Hirakawa K, Maruyama Y, Gotoda T, Hosokawa O, Koike T, Mabe K, Yao T, Inui K, Iishi H, Ogata H, Furuta T, Haruma K; Collaborators. Clinical characteristics and long-term prognosis of type 1 gastric neuroendocrine tumors in a large Japanese national cohort. Dig Endosc 35(6):757-766, 2023. 27. Okami H, Ozawa N, Sohda M, Yokobori T, Osone K, Erkhem-Ochir B, Dorjkhorloo G, Shiraishi T, Okada T, Sano A, Sakai M, Miyazaki T, Ogawa H, Yao T, Oike T, Sato H, Shirabe K, Shibata A, Saeki H. HLA Class I Expression Is Associated with DNA Damage and Immune Cell Infiltration into Dysplastic and Neoplastic Lesions in Ulcerative Colitis. Int J Mol Sci 24(17):13648, 2023. doi: 10.3390/ijms241713648. 28. Okano S, Yamashiro Y, Onagi H, Sasa K, Hayashi T, Takahashi M, Sugimoto K, Sakamoto K, Yao T, Saito T. Tyrosine kinase alterations in colorectal cancer with emphasis on the distinct clinicopathological characteristics. Histopathology 83(5):733-742, 2023. 29. Shiota T, Murata K, Kishimoto M, Yao T, Noura S, Morita S, Akiyoshi T, Okamura S, Imasato M, Furuhata T, Suto T, Takemasa I, Shingai T, Ueda M, Mizuno H, Hisamatsu Y, Takeda T, Fujii M, Kagawa Y, Sugihara K; Study Group of Appendiceal Neoplasms from the Japan Society of Colorectal Cancer Research Group. Clinicopathological features of appendiceal goblet cell adenocarcinoma in Japan: a multicenter retrospective study. Surg Today 53(2):174-181, 2023. 30. Suzuki N, Ikeda A, Ueyama H, Yatagai N, Uemura Y, Yamamoto M, Iwano T, Utsunomiya H, Uchida R, Abe D, Oki S, Akazawa Y, Takeda T, Ueda K, Hojo M, Yao T, Nagahara A. Endoscopic Diagnosis Strategy of Raspberry-Shaped Gastric Lesion in Helicobacter Pylori-Uninfected Patient. J Clin Med 12(17):5437, 2023. doi: 10.3390/jcm12175437

研究テーマ

消化管病理学

研究業績（論文）

1. Morimoto T, Mitomi H, Saito T, Takahashi M, Murakami T, Sakamoto N, Yao T, Watanabe S. Distinct profile of HIF1α, PTCH, EphB2, or DNA repair protein expression and BRAF mutation in colorectal serrated adenoma. J Gastroenterol Hepatol 29: 1192-1199, 2014.
2. Nomura R, Saito T, Mitomi H, Hidaka Y, Lee S-Y, Watanabe S, Yao T, GNAS mutation as an alternative mechanism of activation of the Wnt/β-catenin signaling pathway in gastric adenocarcinoma of the fundic gland type. Hum Pathol 45: 2488-2496, 2014.
3. Saito T, Mitomi H, Imamhasan A, Hayashi T, Mitani K, Takahashi M, Kajiyama Y, Yao T. Downregulation of sFRP-2 by epigenetic silencing activates the β-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. Virchows Arch 464(2):135-43, 2014.
4. Ueyama H, Matsumoto K, Nagahara A, Hayashi T, Yao T, Watanabe S. Gastric adenocarcinoma of the fundic gland type (chief cell predominant type). Endosc 46: 153-157, 2014.
5. Lee S-Y, Saito T, Mitomi H, Hidaka Y, Murakami T, Nomura R, Watanabe S, Yao T. Mutation spectrum in the Wnt/β-catenin signaling pathway in gastric fundic gland-associated neoplasms/polyps. Virchow Arch 467:27–38, 2015
6. Murakami T, Mitomi H, Saito T, Takahashi M, Sakamoto N, Fukui N, Yao T, Watanabe S.Distinct WNT/β-catenin signaling activation in the serrated neoplasia pathway and the adenoma-carcinoma sequence of the colorectum. Mod Pathol. 28(1):146-58, 2015.
7. Gushima R, Yao T, Kurisaki-Arakawa A, Hara K, Hayashi T, Fukumura Y, Saito T, Arakawa A, Yao K, Sasaki Y. Expression of adipophilin in gastric epithelial neoplasia is associated with intestinal differentiation and discriminates between adenoma and adenocarcinoma. Virchow Arch 468: 169-177, 2016
8. Murakami T, Yao T, Mitomi H, Morimoto T, Ueyama H, Matsumoto K, Saito T, Osada T, Nagahara A, Watanabe S. Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases. Gastric cancer 19(2):498-507，2016
9. Matsumoto K, Ueyama H, Matsumoto K, Akazawa Y, Komori H, Takeda T, Murakami T, Asaoka D, Hojo M, Tomita N, Nagahara A, Kajiyama Y, Yao T, Watanabe S. Clinicopathological features of alpha-fetoprotein producing early gastric cancer with enteroblastic differentiation. World J Gastroenterol 22(36): 8203-8210, 2016.
10. Tajima Y, Murakami T, Saito T, Hiromoto T, Akazawa Y, Sasahara N, Mitomi H, Yao T, Watanabe S. Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma. Digestion 96(2):81-91, 2017.
11. Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Watanabe S. Epigenetic regulation of Wnt/β-catenin signal-associated genes in gastric neoplasia of the fundic gland (chief cell-predominant) type. Pathol Int 67(3):147-155, 2017.
12. Akazawa Y, Ueyama H, Yao T, Komori H, Takeda T, Matsumoto K, Matsumoto K, Asaoka D, Hojo M, Watanabe S, Nagahara A. Usefulness of Demarcation of Differentiated-Type Early Gastric Cancers after Helicobacter pylori Eradication by Magnifying Endoscopy with Narrow-Band Imaging. Digestion 98(3):175-184, 2018.
13. Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K, Suehara Y, Takahashi F, Takamochi K, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. Next-generation sequencing analysis for gastric adenocarcinoma with enteroblastic differentiation: emphasis on the relationship with hepatoid adenocarcinoma. Hum Pathol 78:79-88, 2018.
14. He C, Fukumura Y, Toriyama A, Ogura K, Sasahara N, Mitani K, Yao T. Pyloric Gland Adenoma (PGA) of the Gallbladder: A Unique and Distinct Tumor from PGAs of the Stomach, Duodenum, and Pancreas. Am J Surg Pathol 42(9):1237-1245, 2018.
15. Hiromoto T, Murakami T, Akazawa Y, Sasahara N, Saito T, Sakamoto N, Mitomi H, Nagahara A, Yao T. Immunohistochemical and genetic characteristics of a colorectal mucin-rich variant of traditional serrated adenoma. Histopathology 73(3):444-453, 2018.
16. Murakami T, Mitomi H, Yao T, Saito T, Shibuya T, Sakamoto N, Osada T, Watanabe S. Distinct histopathological characteristics in colorectal submucosal invasive carcinoma arising in sessile serrated adenoma/polyp and conventional tubular adenoma. Virchows Arch 472(3):383-393, 2018.
17. Raposo TP, Comes MS, Idowu A, Agit B, Hassall J, Fadhil W, Nica R, Ecker R, Yao T, Ilyas M. CD10 inhibits cell motility but expression is associated with advanced stage disease in colorectal cancer. Exp Mol Pathol 104(3):190-198, 2018.
18. Yatagai N, Saito T, Akazawa Y, Hayashi T, Yanai Y, Tsuyama S, Ueyama H, Murakami T, Watanabe S, Nagahara A, Yao T. TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation. Virchows 474: 315-324, 2019.
19. Yamashiro Y, Saito T, Hayashi T, Murakami T, Yanai Y, Tsuyama S, Suehara Y, Takamochi K, Yao T. Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation. Histopathology 77: 492-502, 2020.
20. Ueyama H, Yao T, Akazawa Y, Hayashi T, Kurahara K, Oshiro Y, Yamada M, Oda I, Fujioka S, Kusumoto C, Fukuda M, Uchita K, Kadota T, Oono Y, Okamoto K, Murakami K, Matsuo Y, Kato M, Maehata T, Yahagi N, Yasuhara Y, Yada T, Uraushihara K, Yamane T, Matsuo T, Ito M, Maruyama Y, Osako A, Ono S, Kato M, Yagi K, Hashimoto T, Tomita N, Tsuyama S, Saito T, Matsumoto K, Matsumoto K, Watanabe S, Uemura N, Chiba T, Nagahara A. Gastric epithelial neoplasm of fundic-gland mucosa lineage: proposal for a new classification in association with gastric adenocarcinoma of fundic-gland type. J Gastroenterol 56(9):814-828, 2021.
21. Akazawa Y, Ueyama H, Hayashi T, Utsunomiya H, Uchida R, Abe D, Oki S, Suzuki N, Ikeda A, Yatagai N, Komori H, Takeda T, Matsumoto K, Ueda K, Matsumoto K, Asaoka D, Hojo M, Saito T, Yao T, Nagahara A. Clinicopathological and molecular characterization of early gastric adenocarcinoma in Helicobacter pylori-uninfected patients: emphasis on differentiated gastric adenocarcinoma. J Gastroenterol 57:725-734, 2022.
22. Yanai Y, Hayashi T, Tsuyama S, Nasu M, Hashimoto T, Kajiyama Y, Tsurumaru M, Mine S, Orita H, Fukunaga T, Yao T, Saito T. Clinicopathological and mutational analysis of esophageal basaloid squamous cell carcinoma. Virchows Arch 481:477-487, 2022.
23. Abe D, Akazawa Y, Yatagai N, Hayashi T, Ueyama H, Mine S, Fukunaga T, Nagahara A, Yao T, Saito T. Clinicopathological characteristics of gastric adenocarcinoma with enteroblastic differentiation and gastric adenocarcinoma with enteroblastic marker expression. Virchows Arch 483:405-414, 2023.
24. Haruma K, Kinoshita Y, Yao T, Kushima R, Akiyama J, Aoyama N, Kanoo T, Miyata K, Kusumoto N, Uemura N. Randomised clinical trial: 3-year interim analysis results of the VISION trial to evaluate the long-term safety of vonoprazan as maintenance treatment in patients with erosive oesophagitis. BMC Gastroenterol 23(1):139, 2023. doi: 10.1186/s12876-023-02772-w.
25. Kojima M, Yokota M, Yanagisawa N, Kitamura S, Amemiya K, Kawano S, Tsukada Y, Sakuyama N, Nagayasu K, Hashimoto T, Nakashima K, Jiang K, Kanemitsu Y, Fujita F, Akiba J, Notohara K, Itakura J, Sekine S, Sakashita S, Sakamoto N, Ishikawa S, Nakanishi Y, Yao T, Liang WY, Lauwers GY, Ito M, Sakamoto K, Ishii G, Ochiai A. Assessment of Elastic Laminal Invasion Contributes to an Objective pT3 Subclassification in Colon Cancer. Am J Surg Pathol 47(10):1122-1133, 2023.
26. Namikawa K, Kamada T, Fujisaki J, Sato Y, Murao T, Chiba T, Kaizaki Y, Ishido K, Ihara Y, Kurahara K, Suga T, Suzuki H, Ito M, Hirakawa K, Maruyama Y, Gotoda T, Hosokawa O, Koike T, Mabe K, Yao T, Inui K, Iishi H, Ogata H, Furuta T, Haruma K; Collaborators. Clinical characteristics and long-term prognosis of type 1 gastric neuroendocrine tumors in a large Japanese national cohort. Dig Endosc 35(6):757-766, 2023.
27. Okami H, Ozawa N, Sohda M, Yokobori T, Osone K, Erkhem-Ochir B, Dorjkhorloo G, Shiraishi T, Okada T, Sano A, Sakai M, Miyazaki T, Ogawa H, Yao T, Oike T, Sato H, Shirabe K, Shibata A, Saeki H. HLA Class I Expression Is Associated with DNA Damage and Immune Cell Infiltration into Dysplastic and Neoplastic Lesions in Ulcerative Colitis. Int J Mol Sci 24(17):13648, 2023. doi: 10.3390/ijms241713648.
28. Okano S, Yamashiro Y, Onagi H, Sasa K, Hayashi T, Takahashi M, Sugimoto K, Sakamoto K, Yao T, Saito T. Tyrosine kinase alterations in colorectal cancer with emphasis on the distinct clinicopathological characteristics. Histopathology 83(5):733-742, 2023.
29. Shiota T, Murata K, Kishimoto M, Yao T, Noura S, Morita S, Akiyoshi T, Okamura S, Imasato M, Furuhata T, Suto T, Takemasa I, Shingai T, Ueda M, Mizuno H, Hisamatsu Y, Takeda T, Fujii M, Kagawa Y, Sugihara K; Study Group of Appendiceal Neoplasms from the Japan Society of Colorectal Cancer Research Group. Clinicopathological features of appendiceal goblet cell adenocarcinoma in Japan: a multicenter retrospective study. Surg Today 53(2):174-181, 2023.
30. Suzuki N, Ikeda A, Ueyama H, Yatagai N, Uemura Y, Yamamoto M, Iwano T, Utsunomiya H, Uchida R, Abe D, Oki S, Akazawa Y, Takeda T, Ueda K, Hojo M, Yao T, Nagahara A. Endoscopic Diagnosis Strategy of Raspberry-Shaped Gastric Lesion in Helicobacter Pylori-Uninfected Patient. J Clin Med 12(17):5437, 2023. doi: 10.3390/jcm12175437

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研究業績詳細

八尾 隆史（ヤオ タカシ）

八尾隆史（ヤオタカシ）