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研究業績詳細

三井田 孝(ミイダ タカシ)

研究テーマ 各種病態におけるHDL亜分画の変化
研究業績(論文) 1 教育の内容方法の工夫
6年生の選択実習において、各自が興味を持った検査項目に影響する因子について、自分で実験計画をたたてデータを取るよう改訂した
2 作成した教科書、教材、参考書等
(1)心電図演習問題(2003年4月~2008年3月)
 実際の患者データから、代表的な心電図異常
 (頻度が高いか、頻度が低くても生命にかかわるもの)を
 問題形式にまとめた
3 なし
4 その他教育活動上特記すべき事項
(1)高校一年生対象のオープンキャンパス(2003~2007年)
 医学部に興味のある高校生に検査部を案内し業務を紹介

(2)司法修習生に対する医療安全管理の研修(2004年~2007年)
 医療安全管理の現状と問題点についての説明と意見交換
5 なし
6 業績

* Web of Science Researcher ID (A-5589-2012): https://publons.com/researcher/1354319/takashi-miida/

*SCOPUS ID (7006100838)
http://www.scopus.com/authid/detail.url?authorId=7006100838

*Pubmed My Bibliography
https://www.ncbi.nlm.nih.gov/myncbi/16YiiHcdx49/bibliography/public/

*ORCID ID (orcid.org/0000-0002-4294-8030)
http://orcid.org/0000-0002-4294-8030
 

(英文原著論文:2022~2025.06)

1) Sai K, Huicheng Qi, Ogura M, Matsuda K, Miida T. Enhancement of ABCA1 and ABCG1 expression and cholesterol efflux by a metabolite of tipelukast: A potential therapeutic strategy for atherosclerosis. J Atheroscler Thromb (in press)

2) Misawa S, Chonan M, Sano M, Igawa G, Takahashi M, Ito K, Nagasawa T, Furusawa K, Otsuka S, Takeda S, Kawakami T, Wakita M, Tabe Y, Miida T. Species distribution and antifungal susceptibility of fungal blood isolates over a 16-year period at a university hospital. Med Mycol J (in press)

3) Handoh T, Ai T, Inaba H, Yamamoto H, Horiuchi Y, Hori A, Turker I, Tabe Y, Miida T. Knockdown of telethonin reduces contraction and provoked aberrant Ca2+-waves in human iPS cell-induced cardiomyocytes. Juntendo Med J (in press)

4) Horiuchi Y, Hirayama S, Hori A, Ichikawa Y, Soda S, Seino U, Sekihara K, Ueno T, Fukushima Y, Kubono K, Miida T. Preβ1-HDL binds to TG-rich lipoproteins and its release is impaired in the postprandial state among patients with poorly controlled type 2 diabetes. Ann Clin Biochem (in press)

5) Takei S, Teramoto K, Sekiguchi Y, Miida T, Kirikae T, Tada T, Tabe Y. Identification of Elizabethkingia species by MALDI-MS proteotyping. Microbiol Spectr, Vol. 13, No. 3, e0245424, 2025.
Miida T, Hirayama S, Fukushima Y, Hori A, Ito S, Hinata M, Wakita M, Tabata H, Tamura Y, Watada, Kawamori R, Vesper HW, Cobbaert CM. Harmonization of lipoprotein(a) immunoassays using a serum panel value assigned with the IFCC-endorsed mass spectrometry-based reference measurement procedure as a first step towards apolipoprotein standardization. J Atheroscler Thromb, Vol. 32, No. , 580-595, 2025.

6) Kato Y, Ihara H, Takei S, Nakamura A, Fujimoto Y, Handoh T, Kurokawa K, Arai Y, Shibayama K, Sumiyoshi I, Ochi Y, Watanabe J, Hoshi K, Misawa S, Togo S, Naito T, Tabe Y, Miida T, Takahashi K. Antimicrobial susceptibility analysis of a sitafloxacin, clarithromycin, and isepamicin combination in Mycobacterium abscessus species. J Clin Tuberc Other Mycobact Dis, Vol. 36, 100464, 2024.

7) Hori A, Ai T, Inaba H, Hato T, Tanaka K, Sato S, Okamoto M, Horiuchi Y, Paran FJ, Tabe Y, Mori S, Rosales C, Akamatsu W, Murayama T, Kurebayashi N, Sakurai T, Miida T. Carvedilol suppresses ryanodine receptor-dependent Ca2+ bursts in human neurons bearing PSEN1 variants found in early onset Alzheimer’s disease. PLoS One, Vol. 9, No. 8, e0291887, 2024.

8) Takei S, Tabe Y, Miida T, Hishinuma T, Khasawneh A, Kirikae T, Sherchand JB, Tada T. Multidrug-resistant Klebsiella pneumoniae clinical isolates producing NDM- and OXA-type carbapenemase in Nepal. J Glob Antimicrob Resist Vol. 37, 233-243, 2024.

9) Takei S, Teramoto K, Fujimura J, Fujiwara M, Suzuki M, Fukui Y, Sekiguchi Y, Kawakami T, Chonan M, Wakita M, Horiuchi Y, Miida T, Naito T, Kirikae T, Tada T, Tabe Y. Isolation and identification of Wickerhamiella tropicalis from blood culture by MALDI-MS. Front Cell Infect Microbiol, Vol. 14, 1361432, 2024.

10) Kobori Y, Hirayama S, Fukushima Y, Ueno T, Sekihara K, Hori A, Horiuchi Y, Makino S, Nishioka E, Miida T. Low serum carnitine level is associated with increased urinary carnitine excretion in late pregnancy. Ann Clin Biochem, Vol. 61, No. 5, 356–364, 2024.

11) Oshiro S, Mizukoshi F, Mizutani N, Akiwa M, Sekiguchi J, Tada T, Yamamoto Y, Tabe Y, Miida T, Kirikae T. Detection of SARS-CoV-2 omicron variants by immunochromatographic kit. Heliyon, Vol. 9, No. 10, e20913, 2023.

12) Takahashi T, Ai T, Saito K, Nojiri S, Takahashi M, Igawa G, Yamamoto T, Khasawneh A, Faith JP, Takei S, Horiuchi Y, Kanno T, Tobiume M, Hiki M, Wakita M, Miida T, Okuzawa A, Suzuki T, Takahashi K, Naito T, Tabe Y. Assessment of antibody dynamics and neutralizing activity using serological assay after SARS-CoV-2 infection and vaccination. PLoS One, Vol. 18, No. 9, e0291670, 2023.

13) Jin B, Oyama R, Tsuchiya K, Hando T, Wakita M, Yan Y, Saita M, Takei S, Horiuchi Y, Miida T, Tabe Y, Naito T. Investigation of the individual genetic evolution of SARS-CoV-2 in a small cluster during the rapid spread of the BF.5 lineage in Tokyo, Japan. Front Microbiol, Vol. 14, 1229234, 2023.

14) Kubota S, Sasano H, Suzuki M, Fukui Y, Chonan M, Kawakami T, Tabe Y, Miida T, Kimura T, Naito Toshio. Impact of the COVID-19 pandemic on initiation of antibiotic treatment after performing a blood culture and intervention by the antimicrobial stewardship team. Int J Gen Med, Vol. 16, 3713-3719, 2023.
Kai T, Hirayama S, Soda S, Fuwa F, Nakagawa S, Ueno T, Hori A, Miida T. Higher concentration of 25-hydroxycholesterol in treatment-naïve patients with type 2 diabetes compared to healthy individuals. J Clin Lipidol, Vol. 17, No. 3, 384-391, 2023.

15) Kuwabara N, Fuwa F, Sato S, Hirayama S, Miida T, Nakagawa S. Simultaneous determination of cholesterol precursors, plant sterols, and oxysterols in plasma using one-round pretreatment. Med Mass Spectrom, Vol. 7, No. 1, 89-97, 2023.

16) Sagara R, Hirayama S, Ueno T, Hori A, Kobori Y, Kai T, Nishioka E, Matsukawa T, Makino S, Miida T. Lipoprotein lipase concentration in umbilical cord blood reflects neonatal birth weight. Clin Chim Acta, Vol. 542, 117275, 2023.

17) Tsuchiya K, Kimura K, Ai T, Yamamoto T, Nagasaka K, Takemura H, Edahiro Y, Saito K, Horiuchi Y, Misawa S, Takaku T, Ando J, Ando M, Miida T, Uchihashi K, Tabe Y. Bone marrow aspirate examination using the automated blood cell analyzer Sysmex XN-3000. Int J Lab Hematol, Vol. 15, 460-468, 2023.

18) Watanabe J, Ihara H, Takei S, Nakamura A, Fujimoto Y, Handoh T, Kurokawa K, Arai Y, Shibayama K, Sumiyoshi I, Ochi Y, Okabe T, Misawa S, Togo S, Naito T, Tabe Y, Miida T, Takahashi K. The synergetic effect of sitafloxacin-arbekacin combination in the Mycobacterium abscessus species. Sci Rep, Vol. 13, No. 1, 2027, 2023.

19) Takahashi M, Saito K, Ai T, Nojiri S, Khasawneh A, Paran FJ, Horiuchi Y, Takei S, Yamamoto T, Wakita M, Hiki M, Miida T, Naito T, Takahashi K, Tabe Y. Performance evaluation of the Ortho VITROS SARS-CoV-2 Spike-Specific Quantitative IgG test by comparison with the surrogate virus neutralizing antibody test and clinical assessment. PLoS One, Vol. 18, No. 1, e0279779, 2023.

20) Fukuda N, Balikagala B, Ueno T, Anywar DA, Kimura E, Palacpac NMQ, Odongo-Aginya EI, Ogwang M, Horii T, Miida T, Mita T. The impact of sequestration on artemisinin-induced parasite clearance in Plasmodium falciparum malaria in Africa. Clin Infect Dis, Vol. 76, No.9, 1585-1593, 2023.

21) Castleberry M, Raby CA, Ifrim A, Shibata Y, Matsushita S, Ugawa S, Miura Y, Hori A, Miida T, Linton MF, Michell DL, Tsujita M, Vickers KC. High-density lipoproteins mediate small RNA intercellular communication between dendritic cells and macrophages. J Lipid Res, Vol. 64, No. 2, 100328, 2023.

22) Tsuchiya K, Yamamoto N, Hosaka Y, Wakita M, Hiki M, Matsushita Y, Mori H, Hori S, Misawa S, Miida T, Nojiri S, Takahashi K, Naito T, Tabe Y. Molecular characterization of SARS-CoV-2 detected in Tokyo, Japan during five waves: Identification of the amino acid substitutions associated with transmissibility and severity. Front Microbiol, Vol. 13, 912061, 2022.

23) Suzuki K, Tange M, Yamagishi R, Hanada H, Mukai S, Sato T, Tanaka T, Akashi T, Kadomatsu K, Maeda T, Miida T, Takeuchi I, Murakami H, Sekido Y, Murakami-Tonami Y. SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesothelioma. Cell Death Discov, Vol. 8, No. 1, 446, 2022.

24) Takei S, Ai T, Yamamoto T, Igawa G, Kanno T, Tobiume M, Hiki M, Saito K, Khasawneh A, Wakita M, Misawa S, Miida T, Okuzawa A, Suzuki T, Takahashi K, Naito T, Tabe Y. Performance evaluation of the Roche Elecsys ® Anti-SARS-CoV-2 immunoassays by comparison with neutralizing antibodies and clinical assessment. PLoS One, Vol. 17, N0.9, e0274181, 2022.

25) Takahashi M, Ai T, Sinozuka K, Baba Y, Igawa G, Nojiri S, Yamamoto T, Yuri M, Takei S, Saito K, Horiuchi Y, Kanno T, Tobiume M, Khasawneh A, Paran FJ, Hiki M, Wakita M, Miida T, Suzuki T, Okuzawa A, Takahashi K, Naito T, Tabe Y. Activation of SARS-COV-2 neutralizing antibody is slower than elevation of spike-specific IgG, IgM, and nucleocapsid-specific IgG antibodies. Sci Rep, Vol. 12, 14909, 2022.

26) Takei S, Lu YJ, Tohya M, Watanabe S, Misawa S, Tabe Y, Miida T, Mya S, Tin H, Tada Ta, Kirikae T. Spread of carbapenem-resistant Klebsiella pneumoniae clinical isolates producing NDM-type metallo-β-lactamase in Myanmar. Microbiol Spectr, Vol. 10, No. 4, e0067322, 2022.

27) Maki R, Horiuchi Y, Hayashi F, Nojiri S, Takehara I, Iwasaki Y, Miyake K, Miida T, Ai T, Tabe Y. Development of an evaluation model to determine disease severity in COVID-19 using basic laboratory markers. (Letter) Int J Lab Hematol, Vol. 44, No. 5, e245-e249, 2022.

28) Tsuchiya K, Hosaka Y, Takahashi T, Chonan M, Makita Y, Katayama I, Ai T, Idei M, Horiuchi Y, Yamatani K, Wakita M, Misawa S, Okuzawa A, Miida T, Naito T, Takahashi K, Tabe Y. Meals and room temperature storage do not significantly affect feasibility of direct RT-PCR tests for SARS-CoV-2 using saliva. Clin Lab, Vol. 68, No. 6, 1113-1119, 2022.

29) Igawa G, Ai T, Yamamoto T, Ito K, Nojiri S, Saito K, Wakita M, Fukuda H, Hori S, Misawa S, Miida T, Seyama K, Takahashi K, Tabe Y, Naito T. Antibody response and seroprevalence in healthcare workers after the BNT162b2 vaccination in a university hospital at Tokyo. Sci Rep, Vol. 12, No. 1, 8707, 2022.
Takamatsu A, Oshiro S, Mizutani N, Tada T, Tabe Y, Miida T, Kirikae T, Tagashira Y. Correlation of COVID-19 severity and immunoglobulin presence against spike and nucleocapsid proteins in SARS-CoV-2. Viral Immunol, Vol. 35, No. 3, 1-5, 2022.

30) Idei M, Abe M, Tanaka M, Hamada C, Isshiki M, Nakata J, Suzuki Y, Hino O, Miida T. Effluent N-terminal expressed in renal cell carcinoma/mesothelin predicts increased peritoneal permeability in patients undergoing peritoneal dialysis. Ther Apher Dial, Vol. 26, No. 5, 1014-1022, 2022.

31) Oshiro S, Tabe Y, Funatogawa K, Saito K, Tada T, Mizutani N, Akiwa M, Sekiguchi J, Miida T, Kirikae T. Assessment of an immunochromatographic kit for detection of severe acute respiratory syndrome coronavirus 2 and influenza viruses. J Virol Methods, Vol. 302, 114477, 2022.

32) Yamatani K, Ai T, Saito K, Suzuki K, Hori A, Kinjo S, Ikeo K, Ruvolo V, Zhang W, Mak PY, Kaczkowski B, Harada H, Katayama K, Sugimoto Y, Myslinski J, Hato T, Miida T, Konopleva M, Hayashizaki Y, Carter BZ, Tabe Y, Andreeff M. Inhibition of BCL2A1 by STAT5 inactivation overcomes resistance to targeted therapies of FLT3-ITD/D835 mutant AML. Transl Oncol, Vol. 18, 101354, 2022.




(英文総説・エディトリアル)

1) Miida T. Global standardization of lipid/lipoprotein testing. Juntendo Med J, Vol. 70, No. 5, 324-331, 2024.

2) Ogura M, Okazaki S, Okazaki H, Tada H, Dobashi K, Nakamura K, Matsunaga K, Miida T, Minamino T, Yokoyama S, Harada-Shiba M. Transitional medicine of intractable primary dyslipidemias in Japan. J Atheroscler Thromb, Vol. 31, No. 5, 501-519, 2024.

3) Okamura T, Tsukamoto K, Arai H, Fujioka Y, Ishigaki, Koba S, Ohmura H, Shoji T, Yokote K, Yoshida H, Yoshida M, Deguchi J, Dobashi K, Fujiyoshi A, Hamaguchi H, Hara M, Harada-Shiba M, Hirata T, Iida M, Ikeda Y, Ishibashi S, Kanda H, Kihara S, Kitagawa K, Kodama S, Koseki M, Maezawa Y, Masuda D, Miida T, Miyamoto Y, Nishimura R, Node K, Noguchi M, Ohishi M, Saito I, Sawada S, Sone H, Takemoto M, Wakatsuki A, Yanai H. Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2022. J Atheroscler Thromb, Vol. 31, No. 6, 641-853, 2024.

4) Miida T. Blood sampling on admission in patients with acute coronary syndrome (Editorial). J Atheroscler Thromb 30: 1-2, 2023.

5) KurodaKuroda M, Bujo H, Murano T, Yamaguchi T, Ogura M, Ikewaki K, Koseki M, Takeuchi Y, Nakatsuka A, Hori M, Matsuki K, Miida T, Yokoyama S, Wada J, Harada-Shiba M. Current status of familial lecithin cholesterol acyltransferase (LCAT) deficiency in Japan. J Atheroscler Thromb 28: 679-691, 2021.

6) Koyama S, Sekijima Y, Ogura M, Hori M, Matsuki K, Miida T, Harada-Shiba M. Cerebrotendinous xanthomatosis: molecular pathogenesis, clinical spectrum, diagnosis, and disease-modifying treatments. J Atheroscler Thromb 28: 905-925, 2021.

7) Miida T, Hirayama S. Controversy over the atherogenicity of lipoprotein-X. Curr Opin Endocrinol Diabetes 26: 117-123, 2019.

8) Watts GF, Ding PYA, George P, Hagger MS, Hu M, Lin J, Lin KK, Marais AD, Miida T, Nawawi HM, Pang J, Park JE, Gonzalez-Santos LE, Su TC, Truong TH, Santos RD, Soran H, Yamashita S, Tomlinson B for the members of the “Ten Countries Study.” Translational research for improving the care of familial hypercholesterolaemia: The “Ten Countries Study” and beyond. J Atheroscler Thromb 23: 891-900, 2016.

9) Hirayama S, Miida T. Small dense LDL: An emerging risk factor for cardiovascular disease. Clin Chim Acta 414: 215-224, 2012.

10) Miida T, Hirayama S. Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events. Curr Opin Lipidol 21: 70-75, 2010.

11) Miida T, Takahashi A, Ikeuchi T. Prevention of stroke and dementia by statin therapy: Experimental and clinical evidence of their pleiotropic effects, Pharmacol Ther 113: 378-393, 2007.

12) Miida T, Takahashi A, Tanabe N, Ikeuchi T. Can statins really reduce the risk of Alzheimer’s disease and slow its progression? Curr Opin Lipidol 16: 619-623, 2005.

13) Okada M, Matsuto T, Miida T, Obayashi K, Zhu Y, Fueki Y. Lipid analyses for the management of vascular diseases. J Atheroscler Thromb 11: 190-199, 2004.

14) Miida T, Hirayama S, Nakamura Y. Cholesterol-independent effects of statins and its new therapeutic targets: ischemic stroke and dementia. J Atheroscler Thromb 11: 253-264, 2004.



(英文著書)

1) Nagasaka H, Tsukahara H, Miida T. Oxidative stress in inherited metabolic diseases. In: Studies on Pediatric Disorders in Applied Basic Research and Clinical Practice. (Tsukahara H., Kaneko K, Eds.), Springer, New York, NY (U.S.A.), p387-404, 2014.

2) Miida T, Hirayama S. Preβ1-HDL: A native lipid-poor HDL, and its potential as a new marker for HDL metabolism (Chapter 12). In: The HDL Handbook - Biological Functions and Clinical Implications -. (Komoda T, Ed), Academic Press, London (UK), Burlington, San Diego (U.S.A.), p243-259, 2010.

3) Obayashi K, Ando Y, Miida T, Masaaki Nakamura, Taro Yamashita, Mitsuharu Ueda, Katsuki Haraoka, HIsayasu Terazaki, Masahiko Okada. Macroscopic assessment of skin venules in patients with familial amyloidotic polyneuropathy (FAP) using near-infrared spectrophotoscopy: As a marker of autonomic dysfunction. In: Amyloid and Amyloidosis (Gilles G, Kyle RA, Skinner M. Eds.), CRC Press, Boca Raton (U.S.A.), p334-336, 2004.

4) Fielding CJ, Fielding PE, Miida T. High density lipoprotein-cell interactions. In: High Density Lipoproteins and Atherosclerosis (Miller NE, Tall AR, Eds.) Excerpta Medica, Amsterdam (the Netherlands), p 145-152, 1992.

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