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研究業績詳細

河盛隆造（カワモリリュウゾウ）

研究テーマ	糖尿病の病態生理の解明と治療法の開拓
研究業績（論文）	【英文原著】 1. Kadowaki S, Tamura Y, Someya Y, Takeno K, Kaga H, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H. Fatty Liver Has Stronger Association With Insulin Resistance Than Visceral Fat Accumulation in Nonobese Japanese Men. J Endocr Soc. 2019;3(7):1409-1416. Sci Rep. 2019;9(1):3857. 2. Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H. Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity. J Clin Endocrinol Metab. 2019;104(6):2325-2333. 3. Suzuki R, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Kaga H, Sugimoto D, Kadowaki S, Someya Y, Kanazawa A, Kawamori R, Watada H. Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men. 4. Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H. Dysfunction of muscle contraction with impaired intracellular Ca2+ handling in skeletal muscle and the effect of exercise training in male db/db mice. J Appl Physiol (1985). 2019 ;126(1):170-182. 5. Taira M, Imamura M, Takahashi A, Kamatani Y, Yamauchi T, Araki SI, Tanaka N, van Zuydam NR, Ahlqvist E, Toyoda M, Umezono T, Kawai K, Imanishi M, Watada H, Suzuki D, Maegawa H, Babazono T, Kaku K, Kawamori R; SUMMIT Consortium, Groop LC, McCarthy MI, Kadowaki T, Maeda S. A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. PLoS One. 2018;13(12): e0208654. 6. Shioya-Yamada M, Shimada K, Nishitani-Yokoyama M, Sai E, Takeno K, Tamura Y, Watada H, Kawamori R, Daida H, Kawai S. Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes. J Clin Med Res. 2018 ;10(8):630-635. 7. Chinzei K,Shimizu A, MoriＫ, HaradaＫ, TakedaＨ, Hashizume Ｍ, Ishizuka　Ｍ, KatoＮ, KawamoriＲ, KyoＳ, Nagata Ｋ, YamaneＴ, SakumaＩ, OheＫ, Mitsuishi Ｍ, Regulatory Science on AI-based Medical Devices and Systems. Advanced Biomedical Engineering. 2018:7 :118-123 8. Kawamori R, Haneda M, Suzaki K, Cheng G, Shiki K, Miyamoto Y, Solimando F, Lee C, Lee J, George J. Empagliflozin as add-on to linagliptin in a fixed-dose combination in Japanese patients with type 2 diabetes: Glycemic efficacy and safety profile in a 52-week, randomized, placebo-controlled trial. Diabetes Obes Metab. 2018;20:2200-2209 9. Someya Y, Tamura Y, Suzuki R, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Takeno K, Sato J, Kanazawa A, Kawamori R, Watada H. Characteristics of Glucose Metabolism in Underweight Japanese Women. J Endocr Soc. 2018 ;2(3):279-289. 10. Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H. Impaired peripheral insulin sensitivity in non-obese Japanese with type 2 diabetes mellitus and fatty liver. J Diabetes Investig 2018 ; 9(3): 529–535.Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H. Impaired peripheral insulin sensitivity in non-obese Japanese with type 2 diabetes mellitus and fatty liver. J Diabetes Investig 2017 [Epub ahead of print] 11. Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H. Correlates of insulin clearance in apparently healthy non-obese Japanese men. Sci Rep 2017;7: 1462 12. Osada T, Suzuki R, Ogawa A, Tanaka M, Hori M, Aoki S, Tamura Y, Watada H, Kawamori R. Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism. NeuroImage 2017;162:1-12. 13. Eshima H, Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, Kakigi R, Okada T, Sakurai T, Kawamori R, Watada H. Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle. Physiol Rep 2017;5: e13250. 14. Odawara M, Kawamori R,Tajima N, Iwamoto Y, Kageyama S, Yodo Y, Ueki F, Hotta N. 1. Long-term treatment study of global standard dose metformin in Japanese patients with type2 diabetes mellitus. Diabetol Int 2017;8:286-295. 15. Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study. Sci Rep 2017;7:40277. 16. Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2. J Clin Endocrinol Metab 2017;101:3676-3684. 17. Sai E, Shimada K, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H. Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy. Heart Vessels 2017;32:166-174. 18. Koga M, Inada S, Nakao T, Kawamori R, Kasayama S. The Glycated Albumin (GA) to HbA1c Ratio Reflects Shorter-Term Glycemic Control than GA: Analysis of Patients with Fulminant Type 1 Diabetes. J Clin Lab Anal 2017;31(1). 19. Ikeda S, Tamura Y, Kakehi S, Sanada H, Kawamori R, Watada H. Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle. Biochem Biophys Res Commun 2016;473:947-52. 20. Kawamori R, Kaku K, Hanafusa T, Ioriya K, Kageyama S, Hotta N. Clinical study of repaglinide efficacy and safety in type 2 diabetes mellitus patients with blood glucose levels inadequately controlled by sitagliptin. J Diabetes Investig 2016;7:253-9. 21. Kaku K, Kawamori R, Kakuma T. Efficacy and safety for insulin glargine biosimilar in patients with type 1 diabetes mellitus undergoing intensive insulin treatment. Japanese Pharmacology and Therapeutics 2016;44:35-46. 22. Matsuba R, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S. Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies. PLoS One 2016;11:e0154093. 23. Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, Ma RC, Okada Y, Iwata M, Hosoe J, Shojima N, Iwasaki M, Fujita H, Suzuki K, Danesh J, Jørgensen T, Jørgensen ME, Witte DR, Brandslund I, Christensen C, Hansen T, Mercader JM, Flannick J, Moreno-Macías H, Burtt NP, Zhang R, Kim YJ, Zheng W, Singh JR, Tam CH, Hirose H, Maegawa H, Ito C, Kaku K, Watada H, Tanaka Y, Tobe K, Kawamori R, Kubo M, Cho YS, Chan JC, Sanghera D, Frossard P, Park KS, Shu XO, Kim BJ, Florez JC, Tusié-Luna T, Jia W, Tai ES, Pedersen O, Saleheen D, Maeda S, Kadowaki T. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun 2016;7:10531. 24. Yasuda H, Hotta N, Kasuga M, Kashiwagi A, Kawamori R, Yamada T, Baba Y, Alev L, Nakajo K. Efficacy and safety of 40 mg or 60 mg duloxetine in Japanese adults with diabetic neuropathic pain: Results from a randomized, 52-week, open-label study. J Diabetes Investig 2016;7:100-8. 25. Teramukai S, Okuda Y, Miyazaki S, Kawamori R, Shirayama M, Teramoto T. Dynamic prediction model and risk assessment chart for cardiovascular disease based on on-treatment blood pressure and baseline risk factors. Hypertens Res 2016;39:113-8. 26. James E Foley, Vaishali Bhosekar, Kawamori R. Does the treatment of type 2 diabetes mellitus with the DPP -4 inhibitor vildagliptin reduce HbA1c to a greater extent in Japanese patients than in Caucasian patients? Vascular Health and Risk Management 2016;12:9–12. 27. Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet. Am J Physiol Endocrinol Metab 2016;310:E32-40. 28. Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S. Replication study of the association of rs7578597 in THADA, rs10886471 in GRK5, and rs7403531 in RASGRP1 with susceptibility to type 2 diabetes among a Japanese population. Diabetology International 2015;6:306-12. 29. Yuzo S, Hirohito S, Masashi K, Ryuzo K, Yoshihito A, Yoshiharu O, Shiro T, Susumu S, Shigeru M, Isao O, Tamura Y, Watanabe T. Current situation of exercise therapy in patients with diabetes mellitus in Japan (Report no. 1): Nationwide survey to physicians using the questionaires. Journal of the Japan Diabetes Society 2015;58:568-75. 30. Tanaka R, Yamashiro K, Okuma Y, Shimura H, Nakamura S, Ueno Y, Tanaka Y, Miyamoto N, Tomizawa Y, Nakahara T, Furukawa Y, Watada H, Kawamori R, Hattori N, Urabe T. Effects of Pioglitazone for Secondary Stroke Prevention in Patients with Impaired Glucose Tolerance and Newly Diagnosed Diabetes: The J-SPIRIT Study. J Atheroscler Thromb 2015;22:1305-16. 31. Matsuba R, Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S. Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes. PLoS One 2015;10:e0126363. 32. Sai E, Shimada K, Yokoyama T, Sato S, Nishizaki Y, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R,Daida H. Evaluation of myocardial triglyceride accumulation assessed on 1H-magnetic resonance spectroscopy in apparently healthy Japanese subjects. Intern Med 2015;54: 367-373. 33. Watanabe T, Tamura Y, Kakehi S, Funayama T, Takeno K, Kawaguchi M, Yamamoto L, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R,Watada H. Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study. Journal of Diabetes Investigation 2015;6: 164-172. 34. Home PD, Dain M-P, Freemantle N, Kawamori R, Pfohl M, Brette S, Pilorget V, Scherbaum WA, Vespasiani G, Vincent M, Balkau B. Four-year evolution of insulin regimens, glycaemic control, hypoglycaemia and body weight after starting insulin therapy in type 2 diabetes across three continents. Diabetes Res Clin Pract 2015;108(2):350-9. 35. Arakawa S, Watanabe T, Sone H, Tamura Y, Kobayashi M, Kawamori R, Atsumi Y, Oshida Y, Tanaka S, Suzuki S, Makita S, Ohsawa I, Sato Yuzo. The factors that affect exercise therapy for patients with type 2 diabetes in Japan: a nationwide survey. Diabetol Int 2015;6:19-25. 36. Teramoto T, Kawamori R, Miyazaki S, Teramukai S, Sato Y, Okuda Y, Shirayama M. Lipid and blood pressure control for the prevention of cardiovascular disease in hypertensive patients: a subanalysis of the OMEGA study. J Atheroscler Thromb 2015;22:62-75. 37. Katakami N, Kaneto H, Matsuoka TA, Takahara M, Osonoi T, Saitou M, Kawai K, Ishibashi F, Kashiwagi A, Kawamori R, Shimomura I, Yamasaki Y. Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes--an 8-year prospective study. Atherosclerosis 2014;235:408-14. 38. Shimoji K, Uka T, Tamura Y, Yoshida M, Kamagata K, Hori M, Motoi Y, Watada H, Kawamori R, Aoki S. Diffusional kurtosis imaging analysis in patients with hypertension. Jpn J Radiol 2014;32:98-104. 39. Kawamori R, Teramoto T, Miyazaki S, Teramukai S, Miyazaki K, Okuda Y. Relationship between diabetes mellitus and cardiovascular events in hypertensive patients receiving olmesartan-based treatment (OMEGA Study Subanalysis). Journal of the Japan Diabetes Society 2014;57:94-101. 40. Yasunari E, Mita T, Osonoi Y, Azuma K, Goto H, Ohmura C, Kanazawa A, Kawamori R, Fujitani Y, Watada H. Repetitive hypoglycemia increases circulating adrenaline level with resultant worsening of intimal thickening after vascular injury in male Goto-Kakizaki rat carotid artery. Endocrinology 2014;155:2244-53. 41. Kawaguchi M, Tamura Y, Kakehi S, Takeno K, Sakurai Y, Watanabe T, Funayama T, Sato F, Ikeda S, Ogura Y, Saga N, Naito H, Fujitani Y, Kanazawa A, Kawamori R, Watada H. Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular lipid-accumulated nonobese men. J Clin Endocrinol Metab 2014;99:3343-52. 42. Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C, Ma RC, Imamura M, Iwata M, Tsunoda T, Morizono T, Shojima N, So WY, Leung TF, Kwan P, Zhang R, Wang J, Yu W, Maegawa H, Hirose H; DIAGRAM consortium, Kaku K, Ito C, Watada H, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Jia W, Chan JC, Teo YY, Shyong TE, Kamatani N, Kubo M, Maeda S, Kadowaki T. Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet 2014;23:239-46. 43. Daida H, Nohara R, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yokoi H, Yoshida M; Justification for Atherosclerosis Regression Treatment (JART) Investigators. Can intensive lipid-lowering therapy improve the carotid intima-media thickness in Japanese subjects under primary prevention for cardiovascular disease?: The JART and JART extension subanalysis. J Atheroscler Thromb 2014;21:739-54. 44. Yokoi H, Nohara R, Daida H, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yoshida M. Change in carotid intima-media thickness in a high-risk group of patients by intensive lipid-lowering therapy with rosuvastatin: subanalysis of the JART study. Int Heart J 2014;55:146-52. 45. Yoshii H, Onuma T, Yamazaki T, Watada H, Matsuhisa M, Matsumoto M, Kitagawa K, Kitakaze M, Yamasaki Y, Kawamori R; PROFIT-J Study Group. Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: the PROFIT-J study. J Atheroscler Thromb 2014;21:563-573. 46. Sato F, Mita T, Yamamoto R, Hirose T, Ito C, Tamura Y, Yokota A, Someya Y, Uchida T, Uchino H, Kawamori R, Gosho M, Ohmura C, Kanazawa A, Watada H. Reliability and validity of the Japanese version of the Diabetes Quality-Of-Life questionnaire for Japanese patients with type 2 diabetes mellitus. Diabetol Int 2014;5:21-29. 47. Kawamori R, Kaku K, Hanafusa T, Oikawa T, Kageyama S, Hotta N. Effect of combination therapy with repaglinide and metformin hydrochloride on glycemic control in Japanese patients with type 2 diabetes mellitus. J Diabetes Investig 2014;5:72-79. 48. Teramoto T, Kawamori R, Miyazaki S, Teramukai S, Mori Y, Okuda Y, Hiramatsu K; OMEGA Study Group. Risk factors for primary prevention of cardiovascular disease and risk reduction by lipid control: the OMEGA study risk factor sub-analysis. Clin Exp Hypertens 2014;36:236-243.

研究テーマ

糖尿病の病態生理の解明と治療法の開拓

研究業績（論文）

【英文原著】
1. Kadowaki S, Tamura Y, Someya Y, Takeno K, Kaga H, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H. Fatty Liver Has Stronger Association With Insulin Resistance Than Visceral Fat Accumulation in Nonobese Japanese Men. J Endocr Soc. 2019;3(7):1409-1416. Sci Rep. 2019;9(1):3857.
2. Sugimoto D, Tamura Y, Takeno K, Kaga H, Someya Y, Kakehi S, Funayama T, Furukawa Y, Suzuki R, Kadowaki S, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Kanazawa A, Kawamori R, Watada H. Clinical Features of Nonobese, Apparently Healthy, Japanese Men With Reduced Adipose Tissue Insulin Sensitivity. J Clin Endocrinol Metab. 2019;104(6):2325-2333.
3. Suzuki R, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Kaga H, Sugimoto D, Kadowaki S, Someya Y, Kanazawa A, Kawamori R, Watada H. Three days of a eucaloric, low-carbohydrate/high-fat diet increases insulin clearance in healthy non-obese Japanese men.
4. Eshima H, Tamura Y, Kakehi S, Nakamura K, Kurebayashi N, Murayama T, Kakigi R, Sakurai T, Kawamori R, Watada H. Dysfunction of muscle contraction with impaired intracellular Ca2+ handling in skeletal muscle and the effect of exercise training in male db/db mice. J Appl Physiol (1985). 2019 ;126(1):170-182.
5. Taira M, Imamura M, Takahashi A, Kamatani Y, Yamauchi T, Araki SI, Tanaka N, van Zuydam NR, Ahlqvist E, Toyoda M, Umezono T, Kawai K, Imanishi M, Watada H, Suzuki D, Maegawa H, Babazono T, Kaku K, Kawamori R; SUMMIT Consortium, Groop LC, McCarthy MI, Kadowaki T, Maeda S. A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes. PLoS One. 2018;13(12): e0208654.
6. Shioya-Yamada M, Shimada K, Nishitani-Yokoyama M, Sai E, Takeno K, Tamura Y, Watada H, Kawamori R, Daida H, Kawai S. Association Between Visceral Fat Accumulation and Exercise Tolerance in Non-Obese Subjects Without Diabetes. J Clin Med Res. 2018 ;10(8):630-635.
7. Chinzei K,Shimizu A, MoriＫ, HaradaＫ, TakedaＨ, Hashizume Ｍ, Ishizuka　Ｍ, KatoＮ, KawamoriＲ, KyoＳ, Nagata Ｋ, YamaneＴ, SakumaＩ, OheＫ, Mitsuishi Ｍ, Regulatory Science on AI-based Medical Devices and Systems. Advanced Biomedical Engineering. 2018:7 :118-123
8. Kawamori R, Haneda M, Suzaki K, Cheng G, Shiki K, Miyamoto Y, Solimando F, Lee C, Lee J, George J. Empagliflozin as add-on to linagliptin in a fixed-dose combination in Japanese patients with type 2 diabetes: Glycemic efficacy and safety profile in a 52-week, randomized, placebo-controlled trial. Diabetes Obes Metab. 2018;20:2200-2209
9. Someya Y, Tamura Y, Suzuki R, Kaga H, Kadowaki S, Sugimoto D, Kakehi S, Funayama T, Furukawa Y, Takeno K, Sato J, Kanazawa A, Kawamori R, Watada H. Characteristics of Glucose Metabolism in Underweight Japanese Women. J Endocr Soc. 2018 ;2(3):279-289.
10. Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H. Impaired peripheral insulin sensitivity in non-obese Japanese with type 2 diabetes mellitus and fatty liver. J Diabetes Investig 2018 ; 9(3): 529–535.Furukawa Y, Tamura Y, Takeno K, Funayama T, Kaga H, Suzuki R, Watanabe T, Kakehi S, Kanazawa A, Kawamori R, Watada H. Impaired peripheral insulin sensitivity in non-obese Japanese with type 2 diabetes mellitus and fatty liver. J Diabetes Investig 2017 [Epub ahead of print]
11. Kaga H, Tamura Y, Takeno K, Kakehi S, Funayama T, Furukawa Y, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Giacca A, Kanazawa A, Kawamori R, Watada H. Correlates of insulin clearance in apparently healthy non-obese Japanese men. Sci Rep 2017;7: 1462
12. Osada T, Suzuki R, Ogawa A, Tanaka M, Hori M, Aoki S, Tamura Y, Watada H, Kawamori R. Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism. NeuroImage 2017;162:1-12.
13. Eshima H, Tamura Y, Kakehi S, Kurebayashi N, Murayama T, Nakamura K, Kakigi R, Okada T, Sakurai T, Kawamori R, Watada H. Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle. Physiol Rep 2017;5: e13250.
14. Odawara M, Kawamori R,Tajima N, Iwamoto Y, Kageyama S, Yodo Y, Ueki F, Hotta N. 1. Long-term treatment study of global standard dose metformin in Japanese patients with type2 diabetes mellitus. Diabetol Int 2017;8:286-295.
15. Funayama T, Tamura Y, Takeno K, Kawaguchi M, Kakehi S, Watanabe T, Furukawa Y, Kaga H, Yamamoto R, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Effects of alcohol abstinence on glucose metabolism in Japanese men with elevated fasting glucose: A pilot study. Sci Rep 2017;7:40277.
16. Takeno K, Tamura Y, Kawaguchi M, Kakehi S, Watanabe T, Funayama T, Furukawa Y, Kaga H, Yamamoto R, Kim M, Nishitani-Yokoyama M, Shimada K, Daida H, Aoki S, Taka H, Fujimura T, Sawada SS, Giacca A, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Relation between insulin sensitivity and metabolic abnormalities in Japanese men with BMI of 23-25 kg/m2. J Clin Endocrinol Metab 2017;101:3676-3684.
17. Sai E, Shimada K, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H. Myocardial triglyceride content in patients with left ventricular hypertrophy: comparison between hypertensive heart disease and hypertrophic cardiomyopathy. Heart Vessels 2017;32:166-174.
18. Koga M, Inada S, Nakao T, Kawamori R, Kasayama S. The Glycated Albumin (GA) to HbA1c Ratio Reflects Shorter-Term Glycemic Control than GA: Analysis of Patients with Fulminant Type 1 Diabetes.
J Clin Lab Anal 2017;31(1).
19. Ikeda S, Tamura Y, Kakehi S, Sanada H, Kawamori R, Watada H. Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle. Biochem Biophys Res Commun 2016;473:947-52.
20. Kawamori R, Kaku K, Hanafusa T, Ioriya K, Kageyama S, Hotta N. Clinical study of repaglinide efficacy and safety in type 2 diabetes mellitus patients with blood glucose levels inadequately controlled by sitagliptin. J Diabetes Investig 2016;7:253-9.
21. Kaku K, Kawamori R, Kakuma T. Efficacy and safety for insulin glargine biosimilar in patients with type 1 diabetes mellitus undergoing intensive insulin treatment. Japanese Pharmacology and Therapeutics 2016;44:35-46.
22. Matsuba R, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S. Replication Study in a Japanese Population of Six Susceptibility Loci for Type 2 Diabetes Originally Identified by a Transethnic Meta-Analysis of Genome-Wide Association Studies. PLoS One 2016;11:e0154093.
23. Imamura M, Takahashi A, Yamauchi T, Hara K, Yasuda K, Grarup N, Zhao W, Wang X, Huerta-Chagoya A, Hu C, Moon S, Long J, Kwak SH, Rasheed A, Saxena R, Ma RC, Okada Y, Iwata M, Hosoe J, Shojima N, Iwasaki M, Fujita H, Suzuki K, Danesh J, Jørgensen T, Jørgensen ME, Witte DR, Brandslund I, Christensen C, Hansen T, Mercader JM, Flannick J, Moreno-Macías H, Burtt NP, Zhang R, Kim YJ, Zheng W, Singh JR, Tam CH, Hirose H, Maegawa H, Ito C, Kaku K, Watada H, Tanaka Y, Tobe K, Kawamori R, Kubo M, Cho YS, Chan JC, Sanghera D, Frossard P, Park KS, Shu XO, Kim BJ, Florez JC, Tusié-Luna T, Jia W, Tai ES, Pedersen O, Saleheen D, Maeda S, Kadowaki T. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun 2016;7:10531.
24. Yasuda H, Hotta N, Kasuga M, Kashiwagi A, Kawamori R, Yamada T, Baba Y, Alev L, Nakajo K. Efficacy and safety of 40 mg or 60 mg duloxetine in Japanese adults with diabetic neuropathic pain: Results from a randomized, 52-week, open-label study. J Diabetes Investig 2016;7:100-8.
25. Teramukai S, Okuda Y, Miyazaki S, Kawamori R, Shirayama M, Teramoto T. Dynamic prediction model and risk assessment chart for cardiovascular disease based on on-treatment blood pressure and baseline risk factors.
Hypertens Res 2016;39:113-8.
26. James E Foley, Vaishali Bhosekar, Kawamori R. Does the treatment of type 2 diabetes mellitus with the DPP -4 inhibitor vildagliptin reduce HbA1c to a greater extent in Japanese patients than in Caucasian patients? Vascular Health and Risk Management 2016;12:9–12.
27. Kakehi S, Tamura Y, Takeno K, Sakurai Y, Kawaguchi M, Watanabe T, Funayama T, Sato F, Ikeda S, Kanazawa A, Fujitani Y, Kawamori R, Watada H. Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat diet. Am J Physiol Endocrinol Metab 2016;310:E32-40.
28. Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S. Replication study of the association of rs7578597 in THADA, rs10886471 in GRK5, and rs7403531 in RASGRP1 with susceptibility to type 2 diabetes among a Japanese population. Diabetology International 2015;6:306-12.
29. Yuzo S, Hirohito S, Masashi K, Ryuzo K, Yoshihito A, Yoshiharu O, Shiro T, Susumu S, Shigeru M, Isao O, Tamura Y, Watanabe T. Current situation of exercise therapy in patients with diabetes mellitus in Japan (Report no. 1): Nationwide survey to physicians using the questionaires. Journal of the Japan Diabetes Society 2015;58:568-75.
30. Tanaka R, Yamashiro K, Okuma Y, Shimura H, Nakamura S, Ueno Y, Tanaka Y, Miyamoto N, Tomizawa Y, Nakahara T, Furukawa Y, Watada H, Kawamori R, Hattori N, Urabe T. Effects of Pioglitazone for Secondary Stroke Prevention in Patients with Impaired Glucose Tolerance and Newly Diagnosed Diabetes: The J-SPIRIT Study. J Atheroscler Thromb 2015;22:1305-16.
31. Matsuba R, Sakai K, Imamura M, Tanaka Y, Iwata M, Hirose H, Kaku K, Maegawa H, Watada H, Tobe K, Kashiwagi A, Kawamori R, Maeda S. Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes. PLoS One 2015;10:e0126363.
32. Sai E, Shimada K, Yokoyama T, Sato S, Nishizaki Y, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R,Daida H. Evaluation of myocardial triglyceride accumulation assessed on 1H-magnetic resonance spectroscopy in apparently healthy Japanese subjects. Intern Med 2015;54: 367-373.
33. Watanabe T, Tamura Y, Kakehi S, Funayama T, Takeno K, Kawaguchi M, Yamamoto L, Sato F, Ikeda S, Taka H, Fujimura T, Fujitani Y, Kawamori R,Watada H. Effects of sitagliptin on ectopic fat contents and glucose metabolism in type 2 diabetic patients with fatty liver: A pilot study. Journal of Diabetes Investigation 2015;6: 164-172.
34. Home PD, Dain M-P, Freemantle N, Kawamori R, Pfohl M, Brette S, Pilorget V, Scherbaum WA, Vespasiani G, Vincent M, Balkau B. Four-year evolution of insulin regimens, glycaemic control, hypoglycaemia and body weight after starting insulin therapy in type 2 diabetes across three continents. Diabetes Res Clin Pract 2015;108(2):350-9.
35. Arakawa S, Watanabe T, Sone H, Tamura Y, Kobayashi M, Kawamori R, Atsumi Y, Oshida Y, Tanaka S, Suzuki S, Makita S, Ohsawa I, Sato Yuzo. The factors that affect exercise therapy for patients with type 2 diabetes in Japan: a nationwide survey. Diabetol Int 2015;6:19-25.
36. Teramoto T, Kawamori R, Miyazaki S, Teramukai S, Sato Y, Okuda Y, Shirayama M. Lipid and blood pressure control for the prevention of cardiovascular disease in hypertensive patients: a subanalysis of the OMEGA study. J Atheroscler Thromb 2015;22:62-75.
37. Katakami N, Kaneto H, Matsuoka TA, Takahara M, Osonoi T, Saitou M, Kawai K, Ishibashi F, Kashiwagi A, Kawamori R, Shimomura I, Yamasaki Y. Accumulation of oxidative stress-related gene polymorphisms and the risk of coronary heart disease events in patients with type 2 diabetes--an 8-year prospective study. Atherosclerosis 2014;235:408-14.
38. Shimoji K, Uka T, Tamura Y, Yoshida M, Kamagata K, Hori M, Motoi Y, Watada H, Kawamori R, Aoki S. Diffusional kurtosis imaging analysis in patients with hypertension. Jpn J Radiol 2014;32:98-104.
39. Kawamori R, Teramoto T, Miyazaki S, Teramukai S, Miyazaki K, Okuda Y. Relationship between diabetes mellitus and cardiovascular events in hypertensive patients receiving olmesartan-based treatment (OMEGA Study Subanalysis). Journal of the Japan Diabetes Society 2014;57:94-101.
40. Yasunari E, Mita T, Osonoi Y, Azuma K, Goto H, Ohmura C, Kanazawa A, Kawamori R, Fujitani Y, Watada H. Repetitive hypoglycemia increases circulating adrenaline level with resultant worsening of intimal thickening after vascular injury in male Goto-Kakizaki rat carotid artery. Endocrinology 2014;155:2244-53.
41. Kawaguchi M, Tamura Y, Kakehi S, Takeno K, Sakurai Y, Watanabe T, Funayama T, Sato F, Ikeda S, Ogura Y, Saga N, Naito H, Fujitani Y, Kanazawa A, Kawamori R, Watada H. Association between expression of FABPpm in skeletal muscle and insulin sensitivity in intramyocellular lipid-accumulated nonobese men. J Clin Endocrinol Metab 2014;99:3343-52.
42. Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C, Ma RC, Imamura M, Iwata M, Tsunoda T, Morizono T, Shojima N, So WY, Leung TF, Kwan P, Zhang R, Wang J, Yu W, Maegawa H, Hirose H; DIAGRAM consortium, Kaku K, Ito C, Watada H, Tanaka Y, Tobe K, Kashiwagi A, Kawamori R, Jia W, Chan JC, Teo YY, Shyong TE, Kamatani N, Kubo M, Maeda S, Kadowaki T. Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet 2014;23:239-46.
43. Daida H, Nohara R, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yokoi H, Yoshida M; Justification for Atherosclerosis Regression Treatment (JART) Investigators. Can intensive lipid-lowering therapy improve the carotid intima-media thickness in Japanese subjects under primary prevention for cardiovascular disease?: The JART and JART extension subanalysis. J Atheroscler Thromb 2014;21:739-54.
44. Yokoi H, Nohara R, Daida H, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yoshida M. Change in carotid intima-media thickness in a high-risk group of patients by intensive lipid-lowering therapy with rosuvastatin: subanalysis of the JART study. Int Heart J 2014;55:146-52.
45. Yoshii H, Onuma T, Yamazaki T, Watada H, Matsuhisa M, Matsumoto M, Kitagawa K, Kitakaze M, Yamasaki Y, Kawamori R; PROFIT-J Study Group. Effects of pioglitazone on macrovascular events in patients with type 2 diabetes mellitus at high risk of stroke: the PROFIT-J study. J Atheroscler Thromb 2014;21:563-573.
46. Sato F, Mita T, Yamamoto R, Hirose T, Ito C, Tamura Y, Yokota A, Someya Y, Uchida T, Uchino H, Kawamori R, Gosho M, Ohmura C, Kanazawa A, Watada H. Reliability and validity of the Japanese version of the Diabetes Quality-Of-Life questionnaire for Japanese patients with type 2 diabetes mellitus. Diabetol Int 2014;5:21-29.
47. Kawamori R, Kaku K, Hanafusa T, Oikawa T, Kageyama S, Hotta N. Effect of combination therapy with repaglinide and metformin hydrochloride on glycemic control in Japanese patients with type 2 diabetes mellitus. J Diabetes Investig 2014;5:72-79.
48. Teramoto T, Kawamori R, Miyazaki S, Teramukai S, Mori Y, Okuda Y, Hiramatsu K; OMEGA Study Group. Risk factors for primary prevention of cardiovascular disease and risk reduction by lipid control: the OMEGA study risk factor sub-analysis. Clin Exp Hypertens 2014;36:236-243.

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河盛 隆造（カワモリ リュウゾウ）

河盛隆造（カワモリリュウゾウ）