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研究業績詳細

末原義之（スエハラヨシユキ）

研究テーマ	整形外科学、ゲノム医療、骨軟部腫瘍、腫瘍学、再生医療、リハビリテーション、転移性骨腫瘍、腫瘍用人工関節、がん遺伝子パネル検査、プレシジョンメディシン、シングルセル解析、空間的ゲノム解析、GIST、肺癌
研究業績（論文）	本業績目録は、英文原著論文、総説、著書、学会発表、招待講演、研究助成報告書等の主要業績をまとめたものである。英文原著論文は約150報に及び、骨軟部腫瘍、肉腫、GIST、肺癌、融合遺伝子、チロシンキナーゼ異常、プロテオーム解析、腫瘍マーカー、がんゲノム医療、Precision Oncology、再生医療、シングルセル解析、空間的ゲノム解析など、幅広い領域で研究成果を発表してきた。代表的な研究成果には、GISTにおけるPfetinを含む予後バイオマーカー研究、滑膜肉腫・Ewing肉腫・骨肉腫における分子標的探索、肺癌におけるRET融合遺伝子研究、軟部肉腫におけるNTRK/ROS1融合遺伝子の同定、がん遺伝子パネル検査およびC-CATデータを用いた骨軟部腫瘍の全国規模ゲノム解析、シングルセル・空間的ゲノム解析を用いた希少がん研究が含まれる。近年では、C-CATデータベースを用いた骨軟部腫瘍における包括的がんゲノムプロファイリング検査の研究がThe Journal of Bone & Joint Surgeryにin pressとして採択されており、希少がん・骨軟部腫瘍領域におけるがんゲノム医療の社会実装に関する主要業績の一つである。業績概数「英文原著」　約150報「英文総説」　約2報「英文著書」　約1件「和文原著」　約20報「和文総説」　約15報「和文著書」　約7件「海外学会講演の要旨」　約100報「和文報告その他」　約330報・件「研究助成報告書」　約10報「学会の主催」　1件「国内学会シンポジウム・招待講演の要旨」　約35報「国内学会講演の要旨」　約290報主要な英文原著論文はPubMedおよびResearchmapを参照。和文原著、和文報告、研究助成報告書、学会主催、シンポジウム・招待講演、国内学会講演・一般演題等については、Researchmap、医中誌、KAKEN / NRID、および各学会プログラム・抄録集を参照。 Researchmap: https://researchmap.jp/ysuehara PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Yoshiyuki+Suehara&sort=date KAKEN / NRID: https://nrid.nii.ac.jp/ja/nrid/1000070509405/ 医中誌: 必要に応じて検索・参照「英文原著」 1. Kamio S, Ikegami M, Kitada R, Miwa S, Ogura K, Iwata S, Kawai A, Kobayashi E, Suehara Y, Kohsaka S. Differences Among Genomic Profiling Tests for Bone and Soft-Tissue Sarcomas in a Universal Health Insurance System. The Journal of Bone & Joint Surgery. Online published. corresponding author. 2. Kamio S, Ogura K, Suehara Y, Kitada R, Ikegami M, Sunami K, Koyama T, Yamamoto N, Shimomura S, Kondo H, et al. Analysis of comprehensive genomic profiling test for Ewing sarcoma in pediatric patients and adults using the nationwide clinical and genomic database in Japan. Japanese Journal of Clinical Oncology. 2026;56(1):33–39. doi: 10.1093/jjco/hyaf174. 3. Suehara Y, Hasegawa K, Majima Y, Mita N, Barbier S, Bogoeva N, Kato S. Patient and physician preferences for cancer panel testing in Japan: a best-worst scaling study. BMJ Open. 2025;15(8):e097620. doi: 10.1136/bmjopen-2024-097620. 4. Onagi H, Son R, Oguchi A, Sano K, Sasa K, Hasegawa N, Akaike K, Kubota D, Takagi T, Hayashi T, Ishijima M, Yao T, Suehara Y, Murakawa Y, Saito T. Potential involvement of myostatin in smooth muscle differentiation in pleomorphic leiomyosarcoma among high-grade sarcomas. International Journal of Molecular Sciences. 2025;26(16):7676. doi: 10.3390/ijms26167676. 5. Terashima Y, Park S, Ikeuchi H, Hayashi T, Kojima S, Ueno T, Ikegami M, Kitada R, Suehara Y, Tanaka S, Suzuki K, Mano H, Takamochi K, Kohsaka S. Discovery of novel RASGRF2 fusions as a therapeutic target in lung adenocarcinoma of never or light smokers. Cancer Science. 2025;116(10):2868–2881. doi: 10.1111/cas.70142. 6. Aihara Y, Ikegami M, Suehara Y, Watanabe T, Yoshimoto S, Mori T, Mano H, Kohsaka S, Suzuki S. Clinical presentation and prognostic factors of eyelid sebaceous carcinoma. Japanese Journal of Ophthalmology. 2025;69(4):595–605. doi: 10.1007/s10384-025-01187-2. 7. Suehara Y, Kitada R, Kamio S, Ogura K, Iwata S, Kobayashi E, Kawai A, Kohsaka S. Analysis of cancer multigene panel testing for osteosarcoma in pediatric and adults using the Center for Cancer Genomics and Advanced Therapeutics database in Japan. Journal of Orthopaedic Science. 2025;30(5):946–953. doi: 10.1016/j.jos.2024.10.016. corresponding author. 8. Sasa K, Son R, Oguchi A, Ashizawa K, Hasegawa N, Kubota D, Suehara Y, Takagi T, Okubo T, Akaike K, Sugimoto K, Takahashi M, Sakamoto K, Hashimoto T, Mine S, Fukunaga T, Ishijima M, Hayashi T, Yao T, Murakawa Y, Saito T. NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts. Sci Rep. 2024 14(1):768. 9. Hasegawa N, Hayashi T, Niizuma H, Kikuta K, Imanishi J, Endo M, Ikeuchi H, Sasa K, Sano K, Hirabayashi K, Takagi T, Ishijima M, Kato S, Kohsaka S, Saito T, Suehara Y. Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing. Clin Orthop Relat Res. 2024;482(3): 549-563 corresponding author 10. Kaino A, Niizuma H, Katayama S, Irie M, Nakano T, Sato D, Saito T, Kato S, Suehara Y, Sasahara Y, Kikuchi A. Two-year crizotinib monotherapy induced durable complete response of pediatric ALK-positive inflammatory myofibroblastic tumor. Pediatr Blood Cancer. 2023 70(8):e30330. 11. Kanamori K, Suina K, Shukuya T, Takahashi F, Hayashi T, Hara K, Saito T, Mitsuishi Y, Shimamura SS, Winardi W, Tajima K, Ko R, Mimori T, Asao T, Itoh M, Kawaji H, Suehara Y, Takamochi K, Suzuki K, Takahashi K. CALML5 is a novel diagnostic marker for differentiating thymic squamous cell carcinoma from type B3 thymoma. Thorac Cancer. 2023 14(12):1089-1097. 12. Hayashi T, Kishi M, Takamochi K, Hosoya M, Kohsaka S, Kishikawa S, Ura A, Sano K, Sasahara N, Suehara Y, Takahashi F, Saito T, Suzuki K, Yao T; Tokyo Metropolitan Innovative Oncology Research Group (TMIG). Expression of paired box 9 defines an aggressive subset of lung adenocarcinoma preferentially occurring in smokers. Histopathology. 2023 82(5):672-683. 13. Sasa K, Saito T, Kurihara T, Hasegawa N, Sano K, Kubota D, Akaike K, Okubo T, Hayashi T, Takagi T, Ishijima M, Suehara Y. Establishment of Rapid and Accurate Screening System for Molecular Target Therapy of Osteosarcoma. Technol Cancer Res Treat. 2022 ;21:15330338221138217. corresponding author 14. Morii T, Anazawa U, Sato C, Iwata S, Nakagawa M, Endo M, Nakamura T, Ikuta K, Nishida Y, Nakayama R, Udaka T, Kawamoto T, Kito M, Sato K, Imanishi J, Akiyama T, Kobayashi H, Nagano A, Outani H, Toki S, Nishisho T, Sasa K, Suehara Y, Kawano H, Ueda T, Morioka H. Dedifferentiated liposarcoma in the extremity and trunk wall: A multi-institutional study of 132 cases by the Japanese Musculoskeletal Oncology Group (JMOG). Eur J Surg Oncol. 2023 49(2):353-361. 15. Tanaka K, Machida R, Kawai A, Nakayama R, Tsukushi S, Asanuma K, Matsumoto Y, Hiraga H, Hiraoka K, Watanuki M, Yonemoto T, Abe S, Katagiri H, Nishida Y, Nagano A, Suehara Y, Kawashima H, Kawano M, Morii T, Hatano H, Toguchida J, Okuma T, Takeyama M, Takenaka S, Akisue T, Furuta T, Emori M, Hiruma T, Outani H, Yamamoto T, Kataoka T, Fukuda H, Ozaki T, Iwamoto Y. Perioperative Adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-risk soft tissue sarcomas: randomised, phase II/III study JCOG1306. Br J Cancer. 2022 127(8):1487-1496. 16. Yamashita A, Suehara Y, Hayashi T, Takagi T, Kubota D, Sasa K, Hasegawa N, Ishijima M, Yao T, Saito T. Molecular and clinicopathological analysis revealed an immuno-checkpoint inhibitor as a potential therapeutic target in a subset of high-grade myxofibrosarcoma. Virchows Arch. 2022 481(4):1-17. 17. Takamochi K, Hara K, Hayashi T, Kohsaka S, Takahashi F, Suehara Y, Shimokawa M, Suzuki K. Clinical relevance of PD-L2 expression in surgically resected lung adenocarcinoma. Lung Cancer. 2022 168:50-58. 18. Sasa K, Saito T, Kurihara T, Hasegawa N, Sano K, Kubota D, Akaike K, Okubo T, Hayashi T, Takagi T, Yao T, Ishijima M, Suehara Y. IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma. Discov Oncol. 2021 12(1):57. doi: 10.1007/s12672-021-00453-2. corresponding author 19. Sasa K, Saito T, Kurihara T, Hasegawa N, Sano K, Kubota D, Akaike K, Okubo T, Hayashi T, Takagi T, Yao T, Ishijima M, Suehara Y. Endoplasmic Reticulum Stress in Osteosarcoma: IRE1α-XBP1 Inhibition Exerts Anti-Tumor Activity. J Oncol Res Ther. 2022 7: 10157. corresponding author 20. Kishikawa S, Hayashi T, Saito T, Takamochi K, Sasa K, Suehara Y, Takahashi F, Sasahara N, Kohsaka S, Suzuki K, Yao T. Distinct properties of pure- and mixed-type high-grade fetal lung adenocarcinomas by genetic profiling and transcription factor expression. Virchows Arch. 2022 480(3):609-619. doi: 10.1007/s00428-021-03247-7. 21. Smith RS, Odintsov I, Liu Z, Lui AJ, Hayashi T, Vojnic M, Suehara Y, Delasos L, Mattar MS, Hmeljak J, Ramirez HA, Shaw M, Bui G, Hartono AB, Gladstone E, Kunte S, Magnan H, Khodos I, De Stanchina E, La Quaglia MP, Yao J, Laé M, Lee SB, Spraggon L, Pratilas CA, Ladanyi M, Somwar R. Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling. Dis Model Mech. 2022 Jan 1;15(1):dmm047621. doi: 10.1242/dmm.047621. 22. Takamochi K, Hara K, Hayashi T, Kohsaka S, Takahashi F, Suehara Y, Suzuki K. Programmed death-ligand 1 expression and its associations with clinicopathological features, prognosis, and driver oncogene alterations in surgically resected lung adenocarcinoma. Lung Cancer. 2021 Nov;161:163-170. doi: 10.1016/j.lungcan.2021.09.011. 23. Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M. iPSC-Derived Neoantigen-Specific CTL Therapy for Ewing Sarcoma. Cancer Immunol Res. 2021 Oct;9(10):1175-1186. doi: 10.1158/2326-6066.CIR-21-0193. 24. Hasegawa N, Kohsaka S, Kurokawa K, Shinno Y, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Suehara Y, Ishijima M, Goto Y, Kojima Y, Yonemori K, Hayashi T, Saito T, Shukuya T, Takahashi F, Takahashi K, Mano H. Highly sensitive fusion detection using plasma cell-free RNA in non-small-cell lung cancers. Cancer Sci. 2021 Oct;112(10):4393-4403. doi: 10.1111/cas.15084. Epub 2021 Aug 18. 25. Sano K, Hayashi T, Suehara Y, Hosoya M, Takamochi K, Kohsaka S, Kishikawa S, Kishi M, Saito S, Takahashi F, Kaneko K, Suzuki K, Yao T, Ishijima M, Saito T. Transcription start site-level expression of thyroid transcription factor 1 isoforms in lung adenocarcinoma and its clinicopathological significance. J Pathol Clin Res. 2021 Jul;7(4):361-374. doi: 10.1002/cjp2.213. Epub 2021 May 20. 26. Takeuchi K, Ogawa H, Kuramitsu N, Akaike K, Goto A, Aoki H, Lassar A, Suehara Y, Hara A, Matsumoto K, Akiyama H. Colchicine protects against cartilage degeneration by inhibiting MMP-13 expression via PLC-γ1 phosphorylation. Osteoarthritis Cartilage. 2021 Nov;29(11):1564-1574. doi:10.1016/j.joca.2021.08.001. Epub 2021 Aug 20. 27. Yamashiro Y, Kurihara T, Hayashi T, Suehara Y, Yao T, Kato S, Saito T. NTRK fusion in Japanese colorectal adenocarcinomas. Sci Rep. 2021 Mar 11;11(1):5635. doi: 10.1038/s41598-021-85075-y. PMID: 33707574 28. Sasa K, Suehara Y, Takagi T, Sano K, Hayashi T, Saito T. Nodular fasciitis adjacent to the left humerus in a 15-year-old boy. Human Pathology: Case Reports Volume 23, March 2021, Article number 200478. https://doi.org/10.1016/j.ehpc.2021.200478 29. Kohsaka S, Hirata M, Ikegami M, Ueno T, Kojima S, Sakai T, Ito K, Naka N, Ogura K, Kawai A, Iwata S, Ohkuma T, Yonemoto T, Kobayashi H, Suehara Y, Hiraga H, Kawamoto T, Motoi T, Oda Y, Matsubara D, Matsuda K, Nishida Y, Mano H. Comprehensive molecular and clinicopathological profiling of desmoid tumors. Eur J Cancer. 2021 Mar;145:109-120. doi: 10.1016/j.ejca.2020.12.001. PMID: 33444924 30. Hayashi T, Kohsaka S, Takamochi K, Kishikawa S, Sano K, Hara K, Suehara Y, Takahashi F, Saito T, Suzuki K, Yao T. Histological Characteristics of Lung Adenocarcinoma with Uncommon Actionable Alterations: Special Emphasis on MET exon 14 Skipping Alterations. Histopathology. 2021 Jun;78(7):987-999. doi: 10.1111/his.14311. PMID: 33249657 31. Shimada Y, Naito T, Hayashi T, Saito T, Suehara Y, Chihaya Kakinuma C, Nozaki Y, Takagi H, Yao T. Establishment of PDX model derived from soft tissue tumor. J Toxicol Pathol. 2021 Jan;34(1):89-93. doi: 10.1293/tox.2020-0061. PMID: 33627948) 32. Ura A, Saito T, Motoi T, Takagi T, Suehara Y, Kurihara T, Sano K, Sasa K, Hayashi T, Yao T. Correction to: A case of primary distal-type epithelioid sarcoma of the lumbar vertebra with a review of literature. Virchows Archi 2020 Oct 25. doi: 10.1007/s00428-020-02955-w. Online ahead of print. PMID: 33103211 33. Iwata S, Akira Kawai, Ueda T, Ishii T, Yonemoto T, Suzuki Y, Kikuta K, Imanishi J, Okubo T, Sotobori T, Murata H, Kunisada T, Kakunaga S, Hiraoka K, Yanagawa T, Kawasaki M, Nishimura S, Okamoto T, Anazawa U, Hakozaki M, Imura Y, Takenaka S, Kobayashi E, Ogura K, Yasuda T, Akiyama T, Hosaka M, Watanuki M, Terauchi R, Otsuka T, Aiba H, Asanuma K, Abe S, Sato K, Yoshida Y, Suehara Y, Akaike K, Hiraga H, Kawano H, Shinoda Y. Symptomatic venous thromboembolism in patients with malignant bone and soft tissue tumors: a prospective multicenter cohort study. Annals of Surgical Oncology 2020 Nov 9. doi: 10.1245/s10434-020-09308-6. Online ahead of print.PMID: 33165723 34. Kurihara T, Suehara Y, Akaike K, Hayashi T, Kohsaka S, Ueno T, Hasegawa N, Takagi T, Okubo T, Kim Y, Mano H, Yao T, Kaneko K, Saito T. Nanostring-based screening for tyrosine kinase fusions in inflammatory myofibroblastic tumors. Sci Rep. 2020 Oct 30;10(1):18724. doi: 10.1038/s41598-020-75596-3. 35. Kim Y, Kobayashi E, Suehara Y, Ito A, Kubota D, Tanzawa Y, Endo M, Nakatani F, Kagamu H, Nakatsura T, Kawai A, Kaneko K, Kitano S. Immunological status of peripheral blood is associated with prognosis in bone and soft-tissue sarcoma patients. Oncology Reports. 2021 Mar;21(3):212. doi: 10.3892/ol.2021.12473. PMID: 33510813 36. Kishikawa S, Hayashi T, Saito T, Takamochi K, Kohsaka S, Sano K, Sasahara N, Sasa K, Kurihara T, Suehara Y, Takahashi F, Suzuki K, Yao T. High MUC6 expression level defines a distinct clinicopathological subset of pulmonary invasive mucinous adenocarcinoma. Modern Pathology Mod Pathol. 2021 Apr;34(4):786-797. doi: 10.1038/s41379-020-00690-w. PMID: 33024306 37. Suehara Y, Kohsaka S, Hayashi T, Akaike K, Kurisaki-Arakawa A, Sato S, Kobayashi E, Mizuno S, Ueno T, Morii T, Okuma T, Kurihara T, Hasegawa N, Sano K, Sasa K, Okubo T, Kim Y, Mano H, Saito T. Identification of a novel MAN1A1-ROS1 fusion gene through mRNA-based screening for tyrosine kinase gene aberrations in leiomyosarcoma. Clin Orthop Relat Res. 2021 Apr 1;479(4):838-852. doi: 10.1097/CORR.0000000000001548. PMID: 33196586) corresponding author 38. Tsuyama S, Kohsaka S, Hayashi T, Suehara Y, Hashimoto T, Kajiyama Y, Tsurumaru M, Ueno T, Mano H, Yao T, Saito T. Next generation sequencing for comprehensive analysis of the molecular and clinical characteristics of primary esophageal malignant melanoma. Histopathology 2021 Jan;78(2):240-251. doi: 10.1111/his.14210. PMID: 32654197 39. Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, YaoT. Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations. Human Pathology 2020 Sep;103:42-51. doi: 10.1016/j.humpath.2020.07.007. PMID: 32673682 40. Yamashiro Y, Saito T, Hayashi T, Murakami T, Yanai Y, Tsuyama S, Suehara Y, Takamochi K, Yao T. Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation. Histopathology 2020 Sep;77(3):492-502. doi: 10.1111/his.14158. PMID: 32438490 41. Sano K, Suehara Y, Okubo T, Sasa K, Kurihara T, Akaike K, Kubota D, Torigoe T, Hasegawa N, Ishii M, Y Nakamura, Kim Y, Takagi T, Kaneko K, Hayashi T, Saito T. Preoperative denosumab treatment with curettage maybe a risk factor for recurrence of giant cell tumor of bone. J Orthop Surg. 2020 Jan-Apr;28(2):2309499020929786. doi: 10.1177/2309499020929786.PMID: 32539628) corresponding author 42. Hayashi T, Takamochi K, Kohsaka S, Kishikawa S, Suehara Y, Takahashi F, Sasahara N, Suzuki K, Saito T, Mano H, Yao T. Transformation from EGFR/PTEN co‐mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis. Pathology International 2020 May;70(5):295-299. doi: 10.1111/pin.12919. PMID: 32162763 43. Suehara Y, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H. Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas. Clin Orthop Relat Res. 2020 Nov;478(11):2461-2476. doi: 10.1097/CORR.0000000000001322.PMID: 32567826. corresponding author 44. Kohsaka S, Hayashi T, Nagano M, Ueno T, Kojima S, Kawazu M, Shiraishi Y, Suehara Y, Takahashi F, Takahashi K, Suzuki K, Takamochi K, Mano H. Identification of Novel CD74-NRG2α Fusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers. Journal of Thoracic Oncology 2020 Jun;15(6):948-961. doi: 10.1016/j.jtho.2020.01.021. PMID: 32036070 45. Ihara H, Takahashi F, Mitsuishi Y, Kato M, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa S, Suzuki K, Takahashi K. Nintedanib Inhibits Epithelial Mesenchymal Transition via TGF-β/Smad pathway in Alveolar Epithelial Cells. Respiratory Investigation 2020 Jul;58(4):275-284. doi: 10.1016/j.resinv.2020.01.003. PMID: 32359980 46. Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda I, Ueno T, Kohsaka S, Mano H, Takahashi K. Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation. Thoracic Cancer. 2020 Jan;11(1):140-149. doi: 10.1111/1759-7714.13255. PMID: 31758670 47. Heng M, Gupta A, Chung PW, Healey JH, Vaynrub M, Rose PS, Houdek MT, Lin PP, Bishop AJ, Hornicek FJ, Chen YL, Lozano-Calderon S, Holt GE, Han I, Biau D, Niu X, Bernthal NM, Ferguson PC, Ueda T, Kakunaga S, Kawai A, Sugiura H, Kidani T, Kunisasa T, Ozaki T, Ae K, Nagano A, Ohno T, Hiraoka K, Yamamoto N, Tsuchiya H, Matsumoto Y, Yanagawa T, Nakayama R, Morioka H, Kubo T, Simose S, Yamagami Y, Yamamoto T, Kawasaki M, Torigoe T, Yazawa Y, Akiyama T, Gokita T, Manabe J, Kaya M, Emori M, Nakamura T, Matsumine A, Sugihara S, Yokouchi M, Komiya S, Suehara Y, Takagi T, Kawamoto T, Wasa J, Yonemoto T, Ishii T, Baba I, Hoshi M, Hamada K, Naka N, Sotobori T, Araki N, Okuma T, Goto T, Kobayashi H, Kawano H, Hosaka M, Futani H, Hiraga H, Nishida Y, Griffin A, Razak ARA, Shultz DB, Catton C, Robinson S, Patel SR, Lewis VO, Guadagnolo BA, DeLaney T, Wang H, Raskin K, Callan AK, Henshaw R, Isler M, Mottard S, Chen WM, Traub F, Chen TW, Turcotte RE, Davidson D, Tunn PU, Loong H, Ghert M, Werier J, Clarkson P, Abraham JA, Wunder JS.. The Role of Chemotherapy and Radiotherapy in Extraskeletal Osteosarcoma. Eur J Cancer. 2020 Jan;125:130-141. doi: 10.1016/j.ejca.2019.07.029. PMID: 31806415 48. Hasegawa N, Kohsaka S, Nakamura I, Ueno T, Kojima S, Akaike K, Okubo T , Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H. Detection of sarcoma circulating tumor cells using microfluidic chip type cell sorter and next-generation sequencing. Sci Rep. 9(1):20047. 2019 49. Tsuyama S, Saito T, Akazawa Y, Yanai Y, Yatagai N, Akaike K, Hayashi T, Suehara Y, Takahashi F, Takamochi K, Hashimoto T, Kajiyama Y, Tsurumaru M, Fukunaga T, Yao T. Molecular and clinicopathological analyses of esophageal carcinosarcoma with special reference to the differentiation mechanism. Virchows Archiv 475(4):415-424 2019 50. Suehara Y, Mukaihara K, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Akaike K, Kim Y, Kaneko K, Saito T. Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone. Proteomics Clin Appl 13(5):e1800147. 2019 corresponding author 51. Suehara Y, Alex D, Bowman A, Middha S, Zehir A, Chakravarty D, Wang L, Jour G, Nafa K, Hayashi T, Jungbluth AA, Frosina D, Slotkin E, Shukla N, Meyers P, Healey J, Hameed M, Ladanyi M. Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations. Clin Cancer Res. 25(21):6346-6356. 2019 Hidayat M, Mitsuishi Y, Takahashi F, TajimaK, Yae T, Miyahara K, Hayakawa D, 52. Winardi W, Ihara H, KoinumaY, Wirawan A, Nurwidya F, Kato M, Kobayashi I, Takamochi K, Hayashi T, Suehara Y, Moriyama M, Moriyama H, Habu S, Takahashi K. Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer Bosnian Journal of Basic Medical Sciences. 19(4):355-367 2019 53. Tsuda Y, Hirata M, Katayama K, Motoi T, Matsubara D, Oda Y, Fujita M, Kobayashi H, Kawano H, Nishida Y, Sakai T, Okuma T, Goto T, Ogura K, Kawai A, Ae K, Anazawa U, Suehara Y, Iwata S, Miyano S, Imoto S, Shibata T, Nakagawa H, Yamaguchi R, Tanaka S, Matsuda K. Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations. Int J Cancer. 145(12):3276-3284. 2019 54. Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H. Comprehensive assay for the molecular profiling of cancer by using DNA and RNA hybridization capture-based target enrichment from formalin- fixed paraffin-embedded specimens. Cancer Sci. 110(4):1464-1479 2019 55. Kato S, Hayashi T, Suehara Y, Hananoue H, Yamanaka S, Ichikawa Y, Higurashi T,Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T, Yao T, Nakajima A, Syed A, Zehir A, Ladanyi M, Kato S. Multicenter experience with large panel next generation sequencing in patients with advanced solid cancers in Japan. Jpn J Clin Oncol. 49(2):174-182 2019 56. Kurihara T, Suehara Y†, Akaike K, Hayashi T, Okubo T, Kim Y, Takagi T, Kaneko K, Yao T, Saito T. Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report. Human Pathology Case reports 16: 100289 2019 corresponding author †equal first 57. Saito T, Motoi T, Suehara Y, Takagi T, Okubo T, Kurihara T, Hayashi T, Kudo T, Maruyama Y, Kaneko K, YaoT. Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review. Human Pathology Case reports 16: 100288 2019 58. Ishii M, Suehara Y†, Kohsaka S, Tanabe Y, Hayashi T, Kazuno S, Tanabe Y, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T. Proteomic signatures corresponding to the SS18/SSX fusion gene. Oncotarget 9:37509-37519 2018 corresponding author †equal first 59. Sano K, Suehara Y, Tanabe Y, Okubo T, Kim Y, Ishii M, Kawasaki T, Terakado A, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K. The first study on locomotive syndrome in lower amputees. J Adv Med Med Res. 27(5): 1-10, 2018 corresponding author 60. Akaike K, Suehara Y†, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Ishii M, Kurihara T, Youngji K, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T. PPP2R1A regulated by PAX3/FOXO3 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. Oncotarget 9:25206-25215, 2018) corresponding author †equal first 61. Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K,Suehara Y, Takahashi F, Takamochi K, Murakami T, Watanabe S, Yao T. A comprehensive clinicopathological analysis of gastric adenocarcinoma with enteroblastic differentiation using next generation sequencing with emphasis on the distinction from socalled hepatoid adenocarcinoma. Human Pathology 78, 79-88, 2018) 62. Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M, Taguchi T, Takagi T, Kaneko K, Yao T, Saito T. KCTD12 may be negatively regulated by KIT in gastrointestinal stromal tumors. Oncotarget 9:27016-27026, 2018 63. Tanabe Y, Suehara Y†, Kim Y, Nojiri S, Okubo T, Ishii M, Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Okubo N, Saito T, Kaneko K. An The development of the short-form “25-question Geriatric Locomotive Function Scale”. J Adv Med Med Res. 25(10): 1-13, 2018 corresponding author †equal first 64. Tanabe Y, Suehara Y, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T. IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcomas. Oncotarget 9:14428-14443. 2018 corresponding author 65. Hayashi T, Takamochi K, Yanai Y, Mitani K, Tomita H, Mogushi K, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T. Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p40. Human Pathology S0046-8177(18)30037-6. 2018 66. Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T, Kaneko K, Ueno T, Kojima S, Kohashi K, Mano H, Oda Y, Yao T. Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. Human Pathology 2018 72:167–173 67. Kohsaka S, Nagano K, Ueno T, Suehara Y, Hayashi T, Shimada N, Takahashi K, Suzuki K, Takamochi K, Takahashi F, Mano H. High-throughput functional evaluation of variants of unknown significance in EGFR. Science Translational Medicine 2017 9, (416): eaan6566 68. Suehara Y. Development of Novel Therapeutic Strategies in Cancers and Sarcomas. Juntendo Medical Journal 63(2), 95-97. 2017 69. Takamochi K, Takahashi F, Suehara Y, Sato E, Kohsaka S, Hayashi T, Kitano S, Takeuchi K, Mano H, Suzuki K. Is DNA mismatch repair deficiency status a biomarker for immune checkpoint inhibitors in lung adenocarcinoma patients?: Microsatellite instability analysis using the Promega panel. Lung Cancer 2017 110, 26–31 70. Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S, Kobayashi K, Okubo T, Kim Y, Kohsaka S, Saito T, Kaneko K, Suehara Y. Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma. PLOS ONE 2017 12(9): e0185321. corresponding author 71. Suehara Y, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K. Arterial Thoracic Outlet Syndrome (aTOS) and Cerebellar Infarction Following a Stress Fracture of the First Rib and Extensive Callus: A case report. J Bone Joint Surg. Case Connector 2017 7 (3) e64 corresponding author 72. Saito T, Akaike K, Tomomasa R, Suehara Y, Takagi T, Kaneko K, Yao T. A case of epithelioid hemangioma of the right third rib in a 55-year-old man. Int J Clin Exp Pathol. 2016 9(9): 9681-9686 Tomomasa R, Akaike K, Asahina M, Toda-Ishii M, Yashiro D, Suehara Y, Takagi T, 73. Kaneko K, Yao T, Saito T. A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia. Int J Clin Exp Pathol . 2016; 9(7): 7230-7236 74. Kim Y, Suehara Y, Ishii M, Kawasaki T, Matsuoka K, Okubo T, Okubo N, Tanabe Y, Akaike K, Mukaihara K, Kubota D, Maruyama Y, Saito T, Kaneko K. A comparative study of 2 screening tools for locomotive syndrome (the “Loco-check” and the “GLFS-25”): An orthopedic outpatient-based survey. Br J Med Med Res. 2016 17(5): 1-13 corresponding author 75. Kageyama S, Yamaguchi S, Ito S, Suehara Y, Saito T, Akaike K, Miura K, Kato S. A case report of using nivolumab for a malignant melanoma patient with rheumatoid arthritis. Int Canc Conf J. 2016 5(4) 192–196 76. Kim Y, Kobayashi E, Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S. Reduced argininosuccinate synthetase expression in refractory sarcomas. Oncotarget. 2016 7(43) 70832-70844 77. Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota K , Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T. Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors. Modern Pathology. 2016 29, 1424–1432 78. Suehara Y, Osawa H, Kubota D, Kato S, Akaike K, Tanabe Y, Saito T, Kaneko K. Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy: A case report. J Bone Joint Surg. Case Connector 2016 6 (3): e70. corresponding author 79. Akaike K, Toda-Ishii M, Suehara Y, Takagi T, Kaneko K,Yao T, Saito T. Paget's sarcoma with sarcoma-specific TP53 mutation arising from a Japanese patient. Int J Clin Exp Pathol . Int J Clin Exp Pathol . 2016 9(3): 3978-3986 80. Tanabe Y, Suehara Y, Okubo T, Kim Y, Ishii M,Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K. An Outpatient-based Survey on the Recognition of Locomotive Syndrome in Japan: The Results of three Years of Surveys. Br J Med Med Res. 2016 15(9) BJMMR.26127 1-9. corresponding author 81. Mukaihara K, Suehara Y, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi, M, Kaneko K, Saito T. Expression of F-actin-capping protein subunit beta is associated with cell growth and motility in epithelioid sarcoma. BMC cancer. 2016 16(1):206. corresponding author 82. Mukaihara K, Suehara Y, Kohsaka S, Kubota D, Akaike K, Ishii M, Fujimura T, Okubo T, Takagi T, Yao T, Kaneko K, Ladanyi M, Saito T. Protein expression profiling of giant cell tumors of bone treated with denosumab. PLoS ONE. 2016 11(2): e0148401. corresponding author 83. Saito T, Akaike K, Kurisaki Arakawa A, Toda Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T. TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients. Molecular and Clinical Oncology. 2016 4(1):61-64. 84. Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T. TERT promoter mutations are a rare event in gastrointestinal stromal tumors. SpringerPlus 2015, 4:836 85. Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K, Saito T. Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases. PLoS ONE. 2015 10(6):e0129428. corresponding author 86. Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur. Int J Clin Exp Pathol . 2015; 8(3): 3270-3278 87. Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T. Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature. Int J Clin Exp Pathol . 2015; 8(3): 3299-3303 88. Ishii M, Kim Y, Suehara Y, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K. The Recognition of Locomotive Syndrome in 2014: A Cross-sectional Study in the Orthopeadic Outpatients in Tokyo. Br J Med Med Res. 2015 6(6) 606-616. corresponding author 89. Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T. Distinct clinicopathologic features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. Hum Pathol. 2015 46(3): 347-56 90. Kurisaki-Arakawa A, Akaike K, Tomomasa R, Arakawa A, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion. International Journal of Surgery Case Reports. 2014 5(12): 1123-1127 91. Lovly CM, McDonald NT, Chen H, Jin H, Lim D, Suehara Y, Wang Lu, Chen X, Lu P, Red-Brewer M, Johnson DH, Horn L, Ladanyi M, Pao W. Rationale for co-targeting IGF-1R and ALK in ALK fusion positive lung cancer. Nature Medicine 2014 20(9): 1027-34 92. Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T. Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature. Diagn Pathol 2014 9(1): 163. 93. Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S, Kaneko K, Horie S, Yao T. A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate. Int J Clin Exp Pathol. Int J Clin Exp Pathol 2014 7(8):5181-5 94. Akaike K, Suehara Y, Takagi T, Kaneko K, Saito T. Eggshell-like mineralized recurrent lesion in the popliteal region after treatment of giant cell tumor of bone with denosumab. Skeletal Radiol 2014 43(12):1767-72. 95. Kastenhuber ER, Huse JT, Berman SH, Pedraza A, Zhang J, Suehara Y, Viale A, Cavatore M, Heguy A, Szerlip N, Ladanyi M, Brennan CW: Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates. Acta Neuropathologica. 2014 127(5):747-59 96. Toda M, Suehara Y, Akaike K, Okubo T, Kubota D, Mukaihara K, Kaneko K, Yao T, Takagi T, Saito T. Giant-cell tumor of bone arising in the anterior rib with a positive expression of GPX-1: a case report and review of the literature. Int Canc Conf J 2014 3:178–182. corresponding author 97. Mukaihara K, Kubota D, Yoshida A, Asano N, Suehara Y, Kaneko K, Kawai A, Kondo T. Proteomic Profile of Epithelioid Sarcoma. J Proteomics Bioinform. 2014 7: 158-165. 98. Okubo T, Suehara Y, Kawasaki T, Akaike K, Toda M, Okubo N, Kubota D, Mukaihara K, Kim Y, Kaketa T, Homma Y, Shimanouchi N, Saito T, Takagi T and Kaneko K. An Outpatient-based Survey about the Recognition of Locomotive Syndrome and the Results of the Loco-check at a University Hospital in Tokyo. Br J Med Med Res. 2014 4: 3255-3268, 2014. corresponding author 99. Orita H, Ito T, Sakurada M, Kushida T, Maekawa H, Wada R, Suehara Y, Kubota D, and Sato K. Pfetin as a risk factor of recurrence in gastrointestinal stromal tumors. BioMed Research International 2014 : 651935. 100. Kubota T, Yoshida A, Kikuta K, Saito T, Suehara Y, Gotoh M, Kawai A, Kondo T. Proteomic approach to gastrointestinal stromal tumor identified prognostic biomarkers. J Proteomics Bioinform. 2014 7(1):10-16. 101. Suehara Y, Kubota D, Saito T. Tissue Sample Preparation for Biomarker Discovery (Methods in Molecular Biology, 2013 1002:13-23 ) corresponding author 102. Suehara Y, Kohsaka S, Kubota D, Mukaihara K, Akaike K, Mineki R, Fujimura T , Kaneko K, Ladanyi M, Saito T, Kondo T. Proteomic technologies to develop biomarkers and functional analyses for bone and soft tissue tumors. J Proteomics Bioinform. 2013 S3-001. corresponding author 103. Drilon A, Wang L, Hasanovic A, Suehara Y, Lipson D, Stephens P, Ross J, Miller V, Ginsberg M, Zakowski MF, Kris MG, Ladanyi M, Rizvi N: Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas. Cancer Discovery. 2013 3(6):630-5 104. Kondo T, Suehara Y, Kikuta K, Kubota D, Tajima T, Mukaihara K, Ichikawa H, Kawai A; Proteomic approach towards personalized sarcoma treatment: Lessons from prognostic biomarker discovery in gastrointestinal stromal tumor. Proteomics Clin Appl. 2013 7(1-2):70-78 105. Kubota D, Mukaihara K, Yoshida A, Suehara Y, Saito T, Okubo T, Gotoh M, Orita H, Tsuda H, Kaneko K, Kawai A, Kondo T, Sato K, Yao T: The prognostic value of pfetin: A validation study in gastrointestinal stromal tumors using a commercially available antibody. Jpn J Clin Oncol. 2013 43(6):669-75. 106. Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Kaneko K, Yao T: p53 mutations may be involved in malignant transformation of giant cell tumor of bone through interaction with GPX1. Virchows Archiv. 2013 463:67-77. 107. Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K: Desmoplastic fibroma of the rib with cystic change : A case report with review of literature. Skeletal Radiol 2013, 43(5):703-8. 108. Okubo T, Saito T, Takagi T, Torigoe T, Suehara Y, Akaike K, Yao T, Kaneko K: Desmoplastic fibroma of the scapula with fluorodeoxyglucose uptake on positron emission tomography: a case report and literature review. Int J Clin Exp Pathol 2013 15;6:2230-6. 109. Kubota D, Yoshida A, Tsuda H, Suehara Y, Okubo T, Saito T, Orita H, Sato K, Taguchi T, Yao T, Kaneko K, Katai H, Kawai A, Kondo T: Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor. PLos ONE. 2013; 8(8):e73896. 110. Suehara Y, Arcila ME, Wang Lu, Hasanovic A, Ang DC, Ito T, Kimura Y, Drilon A, Guha U, Rusch VW, Kris MG, Zakowski MF, Rizvi NA, Khanin R, Ladanyi M. Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clin Cancer Res. 2012 18(24): 6599-608 111. Suehara Y, Kubota D, Kikuta K, Kaneko K, Kawai A, Kondo T. Discovery of biomarkers for osteosarcoma by proteomics approaches. Sarcoma. 2012:425636. corresponding author 112. Saito T, Mitomi H, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Malignant granular cell tumor with unusual long clinical course. An autopsy case with review of literatures. J Cancer Sci Ther. 2012, 4:260-263. 113. Saito T, Mitomi H, Kurisaki A, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Low-grade myofibroblastic sarcoma of the distal femur. Int J Surg Case Rep, 2012; 4(2): 195-199. 114. Kubota D, Okubo T, Saito T, Suehara Y, Yoshida A, Kikuta K, Tsuda H, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T. Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour. Jpn J Clin Oncol, 2012 42(8): 730-41 115. Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Katagiri H, Murata H, Takahashi M, Ito I, Yao T, Kaneko K. Intraneural lipomatous tumor of the median nerve: Three case reports with a review of literature. Int J Surg Case Rep, 2012 3(9): 407-411. 116. Torigoe T, Tomita Y, Iwase Y, Aritomi K, Suehara Y, Oukubo T, Sakurai A, Terakado A, Tatsuya T, Kaneko K, Saito T, Yazawa Y. Pedicle freezing with liquid nitrogen for malignant bone tumour in the radius: a new technique of osteotomy of the ulna. Journal of Orthopaedic Surgery, 2012 20(1):98-102 117. Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Yao T, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T. Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor. Journal of proteomics, 2012 75(4):1089-98. 118. Suehara Y, Tochigi N, Kubota D, Kikuta K, Nakayama R, Seki K, Yoshida A, Ichikawa H, Hasegawa T, Kaneko K, Chuman H, Beppu Y, Kawai A, Kondo T. Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics. Journal of proteomics, 2011 74(6): 829-42. 119. Suehara Y: Proteomic analysis of soft tissue sarcoma. International Journal of Clinical Oncology, 2011 16(2): 727-33. 120. Saito T, Mitomi H, Izumi H, Suehara Y, Okubo T, Torigoe T, Takagi T, Kaneko K, Sato K, Matsumoto T, Yao T. A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. Hum Pathol. 2011 42(5): 727-33. 121. Saito T, Mitomi H, Suehara Y, Okubo T, Torigoe T, Takagi T, Kaneko K, Yao T. A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. Pathology Research and Practice, 2011 207(10):664-9. 122. Kubota D, Orita H, Yoshida A, Gotoh M, Kanda T, Tsuda H, Hasegawa T, Katai H, Shimada Y, Suehara Y, Kikuta K, Sato K, Tochigi N, Seki K, Shibata T, Toyama Y, Beppu Y, Kaneko K, Kawai A, Kondo T Pfetin as a Prognostic Biomarker for Gastrointestinal Stromal Tumor: Validation Study in Multiple Clinical Facilities. Jpn J Clin Oncol, 2011 41(10): 1194-1202. 123. Torigoe T, Terakado A, Suehara Y, Okubo T, Takagi T, Kaneko K, Yazawa Y: Metastatic Soft Tissue Tumors. Journal of Cancer Therapy, 2011 2(5): 746-751. 124. Torigoe T, Terakado A, Suehara Y, Okubo T, Takagi T, Kaneko K, Yazawa Y. The surgical Treatment and Outcome of Pathological Fracture in Patients with Giant Cell Tumor of Bone. Surgical Science, 2011 2(5):228-231. 125. Suehara Y, Nozawa M, Kim SG, Nagayama M, Kojima T, Torigoe T, Kubota D, Yazawa Y, Takagi T, Matsumoto T. Late recurrence of giant cell tumor of bone after adjuvant treatment. J Orthop Surg. 2010 18(1): 122-5. corresponding author 126. Kikuta K, Gotoh M, Kanda T, Tochigi N, Shimoda T, Hasegawa T, Katai H, Shimada Y, Suehara Y, Kawai A, Hirohashi S, Kondo T. Pfetin as a Prognostic Biomarker in Gastrointestinal Stromal Tumor: Novel Monoclonal Antibody and External Validation Study in Multiple Clinical Facilities. Jpn J Clin Oncol, 2010 40(1): 60-72) 127. Kikuta K, Tochigi N, Saito S, Shimoda T, Morioka H, Toyama Y, Hosono A, Suehara Y, Beppu Y, Kawai A, Hirohashi S, Kondo T. Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. Proteomics Clin Appl, 2010 4(5) 560-567. 128. Torigoe T, Terakado A, Suehara Y, Kurosawa H, Yazawa Y, Takagi T. Bone versus soft-tissue sarcomas in the elderly. J Orthop Surg. 2010 18(1): 58-62 129. Suehara Y, Kikuta K, Nakayama R, Tochigi N, Seki K, Ichikawa H, Fujii K, Hasegawa T, Shimoda T, Kurosawa H, Chuman H, Beppu Y, Kawai A, Hirohashi S, Kondo T. GST-P1 as a histological biomarker of synovial sarcoma revealed by proteomics. Proteomics Clin Appl, 2009 3(5), 623-634 130. Suehara Y, Kikuta K, Nakayama R, Fujii K, Ichikawa H, Shibata T, Seki K, Hasegawa T, Gotoh M, Tochigi N, Shimoda T, Shimada Y, Sano T, Beppu Y, Kurosawa H, Hirohashi S, Kawai A, KondoT. Anatomic site-specific proteomic signatures of gastrointestinal stromal tumors. Proteomics Clin Appl, 2009 3(5), 584-59. 131. Suehara Y, Kondo T, Seki K, Shibata T, Fujii K, Gotoh M, Hasegawa T, Shimada Y, Sasako M, Shimoda T, Kurosawa H, Beppu Y, Kawai A, Hirohashi S. Pfetin, as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. Clin Cancer Res 2008 14: 1707-1717. 132. Suehara Y, Kondo T, Seki K, Shibata T, Fujii K, Gotoh M, Hasegawa T, Shimada Y, Sasako M, Shimoda T, Kurosawa H, Beppu Y, Kawai A, Hirohashi S. Pfetin predicts outcome for patients with gastrointestinal stromal tumors. Nature Clinical Practice Oncology 2008 5(7), 364-365. 133. Kawai A, Kondo T, Suehara Y, Kikuta K, Hirohashi S. Protein-expression profiles associated with clinicopathological features of bone and soft tissue sarcomas. Clin Orthop Relat Res. 2008 466(9):2099-2106. 134. Torigoe T, Terakado A, Suehara Y, Kurosawa H. Xanthoma of bone associated with lipoprotein lipase deficiency. Skeletal Radiol. 2008 37(12):1153-1156. 135. Kobayashi E, Kawai A, Endo M, Suehara Y, Takeda K, Nakatani F, Asano T, Sakuraba M, Chuman H, Seki K, Beppu Y. Myxoinflammatory fibroblastic sarcoma. J Orthop Sci. 2008 13(6):566-571. 136. Suehara Y, Kondo T, Fujii K, Hasegawa T, Kawai A, Seki K, Beppu Y, Nishimura T, Kurosawa H, Hirohashi S. Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas. Proteomics 15: 4402-4409, 2006. 137. Suehara Y, Yazawa Y, Hitachi K: Clear cell sarcoma arising from the chest wall. J Orthop Sci. 2004; 9: 171-174. 138. Suehara Y, Yazawa Y, Hitachi K: Intra-abdominal desmoplastic small round cell tumor. The result of ifosfamide-based chemotherapy. Int J Clin Oncol. 2004; 9: 134-138. 139. Suehara Y, Yazawa Y, Hitachi K, Yazawa M. Periosteal osteosarcoma with secondary bone marrow involvement. J Orthop Sci. 2004; 9: 646-649. 140. Suehara Y, Yazawa Y, Hitachi K: Metastatic Bednar tumor with fibrosarcomatous change. J Orthop Sci. 2004; 9: 662-665. 「英文総説」 1. Suehara Y, Kondo T. Pfetin predicts outcome for patients with gastrointestinal stromal tumors. Nat Rev Clin Oncol. 5: 364-365, 2008, doi.org/10.1038/ncponc1143 2. Suehara Y. Development of novel therapeutic strategies in cancers and sarcomas. Juntendo Medical Journal 63, 95-97. 2017 corresponding author (IF: none)

研究テーマ

整形外科学、ゲノム医療、骨軟部腫瘍、腫瘍学、再生医療、リハビリテーション、転移性骨腫瘍、腫瘍用人工関節、がん遺伝子パネル検査、プレシジョンメディシン、シングルセル解析、空間的ゲノム解析、GIST、肺癌

研究業績（論文）

本業績目録は、英文原著論文、総説、著書、学会発表、招待講演、研究助成報告書等の主要業績をまとめたものである。英文原著論文は約150報に及び、骨軟部腫瘍、肉腫、GIST、肺癌、融合遺伝子、チロシンキナーゼ異常、プロテオーム解析、腫瘍マーカー、がんゲノム医療、Precision Oncology、再生医療、シングルセル解析、空間的ゲノム解析など、幅広い領域で研究成果を発表してきた。
代表的な研究成果には、GISTにおけるPfetinを含む予後バイオマーカー研究、滑膜肉腫・Ewing肉腫・骨肉腫における分子標的探索、肺癌におけるRET融合遺伝子研究、軟部肉腫におけるNTRK/ROS1融合遺伝子の同定、がん遺伝子パネル検査およびC-CATデータを用いた骨軟部腫瘍の全国規模ゲノム解析、シングルセル・空間的ゲノム解析を用いた希少がん研究が含まれる。
近年では、C-CATデータベースを用いた骨軟部腫瘍における包括的がんゲノムプロファイリング検査の研究がThe Journal of Bone & Joint Surgeryにin pressとして採択されており、希少がん・骨軟部腫瘍領域におけるがんゲノム医療の社会実装に関する主要業績の一つである。

業績概数
「英文原著」　約150報
「英文総説」　約2報
「英文著書」　約1件
「和文原著」　約20報
「和文総説」　約15報
「和文著書」　約7件
「海外学会講演の要旨」　約100報
「和文報告その他」　約330報・件
「研究助成報告書」　約10報
「学会の主催」　1件
「国内学会シンポジウム・招待講演の要旨」　約35報
「国内学会講演の要旨」　約290報

主要な英文原著論文はPubMedおよびResearchmapを参照。和文原著、和文報告、研究助成報告書、学会主催、シンポジウム・招待講演、国内学会講演・一般演題等については、Researchmap、医中誌、KAKEN / NRID、および各学会プログラム・抄録集を参照。

Researchmap: https://researchmap.jp/ysuehara
PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Yoshiyuki+Suehara&sort=date
KAKEN / NRID: https://nrid.nii.ac.jp/ja/nrid/1000070509405/
医中誌: 必要に応じて検索・参照

「英文原著」
1. Kamio S, Ikegami M, Kitada R, Miwa S, Ogura K, Iwata S, Kawai A, Kobayashi E, Suehara Y*, Kohsaka S. Differences Among Genomic Profiling Tests for Bone and Soft-Tissue Sarcomas in a Universal Health Insurance System. The Journal of Bone & Joint Surgery. Online published. *corresponding author.
2. Kamio S, Ogura K, Suehara Y, Kitada R, Ikegami M, Sunami K, Koyama T, Yamamoto N, Shimomura S, Kondo H, et al. Analysis of comprehensive genomic profiling test for Ewing sarcoma in pediatric patients and adults using the nationwide clinical and genomic database in Japan. Japanese Journal of Clinical Oncology. 2026;56(1):33–39. doi: 10.1093/jjco/hyaf174.
3. Suehara Y, Hasegawa K, Majima Y, Mita N, Barbier S, Bogoeva N, Kato S. Patient and physician preferences for cancer panel testing in Japan: a best-worst scaling study. BMJ Open. 2025;15(8):e097620. doi: 10.1136/bmjopen-2024-097620.
4. Onagi H, Son R, Oguchi A, Sano K, Sasa K, Hasegawa N, Akaike K, Kubota D, Takagi T, Hayashi T, Ishijima M, Yao T, Suehara Y, Murakawa Y, Saito T. Potential involvement of myostatin in smooth muscle differentiation in pleomorphic leiomyosarcoma among high-grade sarcomas. International Journal of Molecular Sciences. 2025;26(16):7676. doi: 10.3390/ijms26167676.
5. Terashima Y, Park S, Ikeuchi H, Hayashi T, Kojima S, Ueno T, Ikegami M, Kitada R, Suehara Y, Tanaka S, Suzuki K, Mano H, Takamochi K, Kohsaka S. Discovery of novel RASGRF2 fusions as a therapeutic target in lung adenocarcinoma of never or light smokers. Cancer Science. 2025;116(10):2868–2881. doi: 10.1111/cas.70142.
6. Aihara Y, Ikegami M, Suehara Y, Watanabe T, Yoshimoto S, Mori T, Mano H, Kohsaka S, Suzuki S. Clinical presentation and prognostic factors of eyelid sebaceous carcinoma. Japanese Journal of Ophthalmology. 2025;69(4):595–605. doi: 10.1007/s10384-025-01187-2.
7. Suehara Y*, Kitada R, Kamio S, Ogura K, Iwata S, Kobayashi E, Kawai A, Kohsaka S. Analysis of cancer multigene panel testing for osteosarcoma in pediatric and adults using the Center for Cancer Genomics and Advanced Therapeutics database in Japan. Journal of Orthopaedic Science. 2025;30(5):946–953. doi: 10.1016/j.jos.2024.10.016. *corresponding author.
8. Sasa K, Son R, Oguchi A, Ashizawa K, Hasegawa N, Kubota D, Suehara Y, Takagi T, Okubo T, Akaike K, Sugimoto K, Takahashi M, Sakamoto K, Hashimoto T, Mine S, Fukunaga T, Ishijima M, Hayashi T, Yao T, Murakawa Y, Saito T. NTRK2 expression in gastrointestinal stromal tumors with a special emphasis on the clinicopathological and prognostic impacts. Sci Rep. 2024 14(1):768.
9. Hasegawa N, Hayashi T, Niizuma H, Kikuta K, Imanishi J, Endo M, Ikeuchi H, Sasa K, Sano K, Hirabayashi K, Takagi T, Ishijima M, Kato S, Kohsaka S, Saito T, Suehara Y*. Detection of Novel Tyrosine Kinase Fusion Genes as Potential Therapeutic Targets in Bone and Soft Tissue Sarcomas Using DNA/RNA-based Clinical Sequencing. Clin Orthop Relat Res. 2024;482(3): 549-563 *corresponding author
10. Kaino A, Niizuma H, Katayama S, Irie M, Nakano T, Sato D, Saito T, Kato S, Suehara Y, Sasahara Y, Kikuchi A. Two-year crizotinib monotherapy induced durable complete response of pediatric ALK-positive inflammatory myofibroblastic tumor. Pediatr Blood Cancer. 2023 70(8):e30330.
11. Kanamori K, Suina K, Shukuya T, Takahashi F, Hayashi T, Hara K, Saito T, Mitsuishi Y, Shimamura SS, Winardi W, Tajima K, Ko R, Mimori T, Asao T, Itoh M, Kawaji H, Suehara Y, Takamochi K, Suzuki K, Takahashi K. CALML5 is a novel diagnostic marker for differentiating thymic squamous cell carcinoma from type B3 thymoma. Thorac Cancer. 2023 14(12):1089-1097.
12. Hayashi T, Kishi M, Takamochi K, Hosoya M, Kohsaka S, Kishikawa S, Ura A, Sano K, Sasahara N, Suehara Y, Takahashi F, Saito T, Suzuki K, Yao T; Tokyo Metropolitan Innovative Oncology Research Group (TMIG). Expression of paired box 9 defines an aggressive subset of lung adenocarcinoma preferentially occurring in smokers. Histopathology. 2023 82(5):672-683.
13. Sasa K, Saito T, Kurihara T, Hasegawa N, Sano K, Kubota D, Akaike K, Okubo T, Hayashi T, Takagi T, Ishijima M, Suehara Y*. Establishment of Rapid and Accurate Screening System for Molecular Target Therapy of Osteosarcoma. Technol Cancer Res Treat. 2022 ;21:15330338221138217. *corresponding author
14. Morii T, Anazawa U, Sato C, Iwata S, Nakagawa M, Endo M, Nakamura T, Ikuta K, Nishida Y, Nakayama R, Udaka T, Kawamoto T, Kito M, Sato K, Imanishi J, Akiyama T, Kobayashi H, Nagano A, Outani H, Toki S, Nishisho T, Sasa K, Suehara Y, Kawano H, Ueda T, Morioka H. Dedifferentiated liposarcoma in the extremity and trunk wall: A multi-institutional study of 132 cases by the Japanese Musculoskeletal Oncology Group (JMOG). Eur J Surg Oncol. 2023 49(2):353-361.
15. Tanaka K, Machida R, Kawai A, Nakayama R, Tsukushi S, Asanuma K, Matsumoto Y, Hiraga H, Hiraoka K, Watanuki M, Yonemoto T, Abe S, Katagiri H, Nishida Y, Nagano A, Suehara Y, Kawashima H, Kawano M, Morii T, Hatano H, Toguchida J, Okuma T, Takeyama M, Takenaka S, Akisue T, Furuta T, Emori M, Hiruma T, Outani H, Yamamoto T, Kataoka T, Fukuda H, Ozaki T, Iwamoto Y. Perioperative Adriamycin plus ifosfamide vs. gemcitabine plus docetaxel for high-risk soft tissue sarcomas: randomised, phase II/III study JCOG1306. Br J Cancer. 2022 127(8):1487-1496.
16. Yamashita A, Suehara Y, Hayashi T, Takagi T, Kubota D, Sasa K, Hasegawa N, Ishijima M, Yao T, Saito T. Molecular and clinicopathological analysis revealed an immuno-checkpoint inhibitor as a potential therapeutic target in a subset of high-grade myxofibrosarcoma. Virchows Arch. 2022 481(4):1-17.
17. Takamochi K, Hara K, Hayashi T, Kohsaka S, Takahashi F, Suehara Y, Shimokawa M, Suzuki K. Clinical relevance of PD-L2 expression in surgically resected lung adenocarcinoma. Lung Cancer. 2022 168:50-58.
18. Sasa K, Saito T, Kurihara T, Hasegawa N, Sano K, Kubota D, Akaike K, Okubo T, Hayashi T, Takagi T, Yao T, Ishijima M, Suehara Y*. IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma. Discov Oncol. 2021 12(1):57. doi: 10.1007/s12672-021-00453-2. *corresponding author
19. Sasa K, Saito T, Kurihara T, Hasegawa N, Sano K, Kubota D, Akaike K, Okubo T, Hayashi T, Takagi T, Yao T, Ishijima M, Suehara Y*. Endoplasmic Reticulum Stress in Osteosarcoma: IRE1α-XBP1 Inhibition Exerts Anti-Tumor Activity. J Oncol Res Ther. 2022 7: 10157. *corresponding author
20. Kishikawa S, Hayashi T, Saito T, Takamochi K, Sasa K, Suehara Y, Takahashi F, Sasahara N, Kohsaka S, Suzuki K, Yao T. Distinct properties of pure- and mixed-type high-grade fetal lung adenocarcinomas by genetic profiling and transcription factor expression. Virchows Arch. 2022 480(3):609-619. doi: 10.1007/s00428-021-03247-7.
21. Smith RS, Odintsov I, Liu Z, Lui AJ, Hayashi T, Vojnic M, Suehara Y, Delasos L, Mattar MS, Hmeljak J, Ramirez HA, Shaw M, Bui G, Hartono AB, Gladstone E, Kunte S, Magnan H, Khodos I, De Stanchina E, La Quaglia MP, Yao J, Laé M, Lee SB, Spraggon L, Pratilas CA, Ladanyi M, Somwar R. Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling. Dis Model Mech. 2022 Jan 1;15(1):dmm047621. doi: 10.1242/dmm.047621.
22. Takamochi K, Hara K, Hayashi T, Kohsaka S, Takahashi F, Suehara Y, Suzuki K. Programmed death-ligand 1 expression and its associations with clinicopathological features, prognosis, and driver oncogene alterations in surgically resected lung adenocarcinoma. Lung Cancer. 2021 Nov;161:163-170. doi: 10.1016/j.lungcan.2021.09.011.
23. Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M. iPSC-Derived Neoantigen-Specific CTL Therapy for Ewing Sarcoma. Cancer Immunol Res. 2021 Oct;9(10):1175-1186. doi: 10.1158/2326-6066.CIR-21-0193.
24. Hasegawa N, Kohsaka S, Kurokawa K, Shinno Y, Takeda Nakamura I, Ueno T, Kojima S, Kawazu M, Suehara Y, Ishijima M, Goto Y, Kojima Y, Yonemori K, Hayashi T, Saito T, Shukuya T, Takahashi F, Takahashi K, Mano H. Highly sensitive fusion detection using plasma cell-free RNA in non-small-cell lung cancers. Cancer Sci. 2021 Oct;112(10):4393-4403. doi: 10.1111/cas.15084. Epub 2021 Aug 18.
25. Sano K, Hayashi T, Suehara Y, Hosoya M, Takamochi K, Kohsaka S, Kishikawa S, Kishi M, Saito S, Takahashi F, Kaneko K, Suzuki K, Yao T, Ishijima M, Saito T. Transcription start site-level expression of thyroid transcription factor 1 isoforms in lung adenocarcinoma and its clinicopathological significance. J Pathol Clin Res. 2021 Jul;7(4):361-374. doi: 10.1002/cjp2.213. Epub 2021 May 20.
26. Takeuchi K, Ogawa H, Kuramitsu N, Akaike K, Goto A, Aoki H, Lassar A, Suehara Y, Hara A, Matsumoto K, Akiyama H. Colchicine protects against cartilage degeneration by inhibiting MMP-13 expression via PLC-γ1 phosphorylation. Osteoarthritis Cartilage. 2021 Nov;29(11):1564-1574. doi:10.1016/j.joca.2021.08.001. Epub 2021 Aug 20.
27. Yamashiro Y, Kurihara T, Hayashi T, Suehara Y, Yao T, Kato S, Saito T. NTRK fusion in Japanese colorectal adenocarcinomas. Sci Rep. 2021 Mar 11;11(1):5635. doi: 10.1038/s41598-021-85075-y. PMID: 33707574
28. Sasa K, Suehara Y, Takagi T, Sano K, Hayashi T, Saito T. Nodular fasciitis adjacent to the left humerus in a 15-year-old boy. Human Pathology: Case Reports Volume 23, March 2021, Article number 200478. https://doi.org/10.1016/j.ehpc.2021.200478
29. Kohsaka S, Hirata M, Ikegami M, Ueno T, Kojima S, Sakai T, Ito K, Naka N, Ogura K, Kawai A, Iwata S, Ohkuma T, Yonemoto T, Kobayashi H, Suehara Y, Hiraga H, Kawamoto T, Motoi T, Oda Y, Matsubara D, Matsuda K, Nishida Y, Mano H. Comprehensive molecular and clinicopathological profiling of desmoid tumors. Eur J Cancer. 2021 Mar;145:109-120. doi: 10.1016/j.ejca.2020.12.001. PMID: 33444924
30. Hayashi T, Kohsaka S, Takamochi K, Kishikawa S, Sano K, Hara K, Suehara Y, Takahashi F, Saito T, Suzuki K, Yao T. Histological Characteristics of Lung Adenocarcinoma with Uncommon Actionable Alterations: Special Emphasis on MET exon 14 Skipping Alterations. Histopathology. 2021 Jun;78(7):987-999. doi: 10.1111/his.14311. PMID: 33249657
31. Shimada Y, Naito T, Hayashi T, Saito T, Suehara Y, Chihaya Kakinuma C, Nozaki Y, Takagi H, Yao T. Establishment of PDX model derived from soft tissue tumor. J Toxicol Pathol. 2021 Jan;34(1):89-93. doi: 10.1293/tox.2020-0061. PMID: 33627948)
32. Ura A, Saito T, Motoi T, Takagi T, Suehara Y, Kurihara T, Sano K, Sasa K, Hayashi T, Yao T. Correction to: A case of primary distal-type epithelioid sarcoma of the lumbar vertebra with a review of literature. Virchows Archi 2020 Oct 25. doi: 10.1007/s00428-020-02955-w. Online ahead of print. PMID: 33103211
33. Iwata S, Akira Kawai, Ueda T, Ishii T, Yonemoto T, Suzuki Y, Kikuta K, Imanishi J, Okubo T, Sotobori T, Murata H, Kunisada T, Kakunaga S, Hiraoka K, Yanagawa T, Kawasaki M, Nishimura S, Okamoto T, Anazawa U, Hakozaki M, Imura Y, Takenaka S, Kobayashi E, Ogura K, Yasuda T, Akiyama T, Hosaka M, Watanuki M, Terauchi R, Otsuka T, Aiba H, Asanuma K, Abe S, Sato K, Yoshida Y, Suehara Y, Akaike K, Hiraga H, Kawano H, Shinoda Y. Symptomatic venous thromboembolism in patients with malignant bone and soft tissue tumors: a prospective multicenter cohort study. Annals of Surgical Oncology 2020 Nov 9. doi: 10.1245/s10434-020-09308-6. Online ahead of print.PMID: 33165723
34. Kurihara T, Suehara Y, Akaike K, Hayashi T, Kohsaka S, Ueno T, Hasegawa N, Takagi T, Okubo T, Kim Y, Mano H, Yao T, Kaneko K, Saito T. Nanostring-based screening for tyrosine kinase fusions in inflammatory myofibroblastic tumors. Sci Rep. 2020 Oct 30;10(1):18724. doi: 10.1038/s41598-020-75596-3.
35. Kim Y, Kobayashi E, Suehara Y, Ito A, Kubota D, Tanzawa Y, Endo M, Nakatani F, Kagamu H, Nakatsura T, Kawai A, Kaneko K, Kitano S. Immunological status of peripheral blood is associated with prognosis in bone and soft-tissue sarcoma patients. Oncology Reports. 2021 Mar;21(3):212. doi: 10.3892/ol.2021.12473. PMID: 33510813
36. Kishikawa S, Hayashi T, Saito T, Takamochi K, Kohsaka S, Sano K, Sasahara N, Sasa K, Kurihara T, Suehara Y, Takahashi F, Suzuki K, Yao T. High MUC6 expression level defines a distinct clinicopathological subset of pulmonary invasive mucinous adenocarcinoma. Modern Pathology Mod Pathol. 2021 Apr;34(4):786-797. doi: 10.1038/s41379-020-00690-w. PMID: 33024306
37. Suehara Y*, Kohsaka S, Hayashi T, Akaike K, Kurisaki-Arakawa A, Sato S, Kobayashi E, Mizuno S, Ueno T, Morii T, Okuma T, Kurihara T, Hasegawa N, Sano K, Sasa K, Okubo T, Kim Y, Mano H, Saito T. Identification of a novel MAN1A1-ROS1 fusion gene through mRNA-based screening for tyrosine kinase gene aberrations in leiomyosarcoma. Clin Orthop Relat Res. 2021 Apr 1;479(4):838-852. doi: 10.1097/CORR.0000000000001548. PMID: 33196586) *corresponding author
38. Tsuyama S, Kohsaka S, Hayashi T, Suehara Y, Hashimoto T, Kajiyama Y, Tsurumaru M, Ueno T, Mano H, Yao T, Saito T. Next generation sequencing for comprehensive analysis of the molecular and clinical characteristics of primary esophageal malignant melanoma. Histopathology 2021 Jan;78(2):240-251. doi: 10.1111/his.14210. PMID: 32654197
39. Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, YaoT. Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations. Human Pathology 2020 Sep;103:42-51. doi: 10.1016/j.humpath.2020.07.007. PMID: 32673682
40. Yamashiro Y, Saito T, Hayashi T, Murakami T, Yanai Y, Tsuyama S, Suehara Y, Takamochi K, Yao T. Molecular and clinicopathological features of colorectal adenocarcinoma with enteroblastic differentiation. Histopathology 2020 Sep;77(3):492-502. doi: 10.1111/his.14158. PMID: 32438490
41. Sano K, Suehara Y*, Okubo T, Sasa K, Kurihara T, Akaike K, Kubota D, Torigoe T, Hasegawa N, Ishii M, Y Nakamura, Kim Y, Takagi T, Kaneko K, Hayashi T, Saito T. Preoperative denosumab treatment with curettage maybe a risk factor for recurrence of giant cell tumor of bone. J Orthop Surg. 2020 Jan-Apr;28(2):2309499020929786. doi: 10.1177/2309499020929786.PMID: 32539628) *corresponding author
42. Hayashi T, Takamochi K, Kohsaka S, Kishikawa S, Suehara Y, Takahashi F, Sasahara N, Suzuki K, Saito T, Mano H, Yao T. Transformation from EGFR/PTEN co‐mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis. Pathology International 2020 May;70(5):295-299. doi: 10.1111/pin.12919. PMID: 32162763
43. Suehara Y*, Kohsaka S, Yamaguchi S, Hayashi T, Kurihara T, Akaike K, Ueno T, Kojima S, Ikegami M, Mizuno S, Okubo T, Kim Y, Kaneko K, Saito T, Kato S, Mano H. Assessment of Predictive Biomarkers of the Response to Pazopanib Based on an Integrative Analysis of High-grade Soft-tissue Sarcomas. Clin Orthop Relat Res. 2020 Nov;478(11):2461-2476. doi: 10.1097/CORR.0000000000001322.PMID: 32567826. *corresponding author
44. Kohsaka S, Hayashi T, Nagano M, Ueno T, Kojima S, Kawazu M, Shiraishi Y, Suehara Y, Takahashi F, Takahashi K, Suzuki K, Takamochi K, Mano H. Identification of Novel CD74-NRG2α Fusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers. Journal of Thoracic Oncology 2020 Jun;15(6):948-961. doi: 10.1016/j.jtho.2020.01.021. PMID: 32036070
45. Ihara H, Takahashi F, Mitsuishi Y, Kato M, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa S, Suzuki K, Takahashi K. Nintedanib Inhibits Epithelial Mesenchymal Transition via TGF-β/Smad pathway in Alveolar Epithelial Cells. Respiratory Investigation 2020 Jul;58(4):275-284. doi: 10.1016/j.resinv.2020.01.003. PMID: 32359980
46. Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda I, Ueno T, Kohsaka S, Mano H, Takahashi K. Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation. Thoracic Cancer. 2020 Jan;11(1):140-149. doi: 10.1111/1759-7714.13255. PMID: 31758670
47. Heng M, Gupta A, Chung PW, Healey JH, Vaynrub M, Rose PS, Houdek MT, Lin PP, Bishop AJ, Hornicek FJ, Chen YL, Lozano-Calderon S, Holt GE, Han I, Biau D, Niu X, Bernthal NM, Ferguson PC, Ueda T, Kakunaga S, Kawai A, Sugiura H, Kidani T, Kunisasa T, Ozaki T, Ae K, Nagano A, Ohno T, Hiraoka K, Yamamoto N, Tsuchiya H, Matsumoto Y, Yanagawa T, Nakayama R, Morioka H, Kubo T, Simose S, Yamagami Y, Yamamoto T, Kawasaki M, Torigoe T, Yazawa Y, Akiyama T, Gokita T, Manabe J, Kaya M, Emori M, Nakamura T, Matsumine A, Sugihara S, Yokouchi M, Komiya S, Suehara Y, Takagi T, Kawamoto T, Wasa J, Yonemoto T, Ishii T, Baba I, Hoshi M, Hamada K, Naka N, Sotobori T, Araki N, Okuma T, Goto T, Kobayashi H, Kawano H, Hosaka M, Futani H, Hiraga H, Nishida Y, Griffin A, Razak ARA, Shultz DB, Catton C, Robinson S, Patel SR, Lewis VO, Guadagnolo BA, DeLaney T, Wang H, Raskin K, Callan AK, Henshaw R, Isler M, Mottard S, Chen WM, Traub F, Chen TW, Turcotte RE, Davidson D, Tunn PU, Loong H, Ghert M, Werier J, Clarkson P, Abraham JA, Wunder JS.. The Role of Chemotherapy and Radiotherapy in Extraskeletal Osteosarcoma. Eur J Cancer. 2020 Jan;125:130-141. doi: 10.1016/j.ejca.2019.07.029. PMID: 31806415
48. Hasegawa N, Kohsaka S, Nakamura I, Ueno T, Kojima S, Akaike K, Okubo T , Takagi T, Suehara Y, Hayashi T, Saito T, Kaneko K, Mano H. Detection of sarcoma circulating tumor cells using microfluidic chip type cell sorter and next-generation sequencing. Sci Rep. 9(1):20047. 2019
49. Tsuyama S, Saito T, Akazawa Y, Yanai Y, Yatagai N, Akaike K, Hayashi T, Suehara Y, Takahashi F, Takamochi K, Hashimoto T, Kajiyama Y, Tsurumaru M, Fukunaga T, Yao T. Molecular and clinicopathological analyses of esophageal carcinosarcoma with special reference to the differentiation mechanism. Virchows Archiv 475(4):415-424 2019
50. Suehara Y*, Mukaihara K, Okubo T, Kurihara T, Hayashi T, Kohsaka S, Kazuno S, Akaike K, Kim Y, Kaneko K, Saito T. Protein Expression Profiles Corresponding to Histological Changes with Denosumab Treatment in Giant Cell Tumors of Bone. Proteomics Clin Appl 13(5):e1800147. 2019 *corresponding author
51. Suehara Y, Alex D, Bowman A, Middha S, Zehir A, Chakravarty D, Wang L, Jour G, Nafa K, Hayashi T, Jungbluth AA, Frosina D, Slotkin E, Shukla N, Meyers P, Healey J, Hameed M, Ladanyi M. Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations. Clin Cancer Res. 25(21):6346-6356. 2019
Hidayat M, Mitsuishi Y, Takahashi F, TajimaK, Yae T, Miyahara K, Hayakawa D,
52. Winardi W, Ihara H, KoinumaY, Wirawan A, Nurwidya F, Kato M, Kobayashi I, Takamochi K, Hayashi T, Suehara Y, Moriyama M, Moriyama H, Habu S, Takahashi K. Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer Bosnian Journal of Basic Medical Sciences. 19(4):355-367 2019
53. Tsuda Y, Hirata M, Katayama K, Motoi T, Matsubara D, Oda Y, Fujita M, Kobayashi H, Kawano H, Nishida Y, Sakai T, Okuma T, Goto T, Ogura K, Kawai A, Ae K, Anazawa U, Suehara Y, Iwata S, Miyano S, Imoto S, Shibata T, Nakagawa H, Yamaguchi R, Tanaka S, Matsuda K. Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations. Int J Cancer. 145(12):3276-3284. 2019
54. Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H. Comprehensive assay for the molecular profiling of cancer by using DNA and RNA hybridization capture-based target enrichment from formalin- fixed paraffin-embedded specimens. Cancer Sci. 110(4):1464-1479 2019
55. Kato S, Hayashi T, Suehara Y, Hananoue H, Yamanaka S, Ichikawa Y, Higurashi T,Ohashi K, Yamaguchi S, Nozaki Y, Terao Y, Saito T, Yao T, Nakajima A, Syed A, Zehir A, Ladanyi M, Kato S. Multicenter experience with large panel next generation sequencing in patients with advanced solid cancers in Japan. Jpn J Clin Oncol. 49(2):174-182 2019
56. Kurihara T, Suehara Y*†, Akaike K, Hayashi T, Okubo T, Kim Y, Takagi T, Kaneko K, Yao T, Saito T. Squamous cell carcinoma arising from chronic osteomyelitis massively expanding into the medullary cavity: A case report. Human Pathology Case reports 16: 100289 2019 *corresponding author †equal first
57. Saito T, Motoi T, Suehara Y, Takagi T, Okubo T, Kurihara T, Hayashi T, Kudo T, Maruyama Y, Kaneko K, YaoT. Fibrocartilaginous mesenchymoma of the tibia with predominant microcystic features: A case report and literature review. Human Pathology Case reports 16: 100288 2019
58. Ishii M, Suehara Y*†, Kohsaka S, Tanabe Y, Hayashi T, Kazuno S, Tanabe Y, Akaike K, Mukaihara K, Kim Y, Okubo T, Takamochi K, Takahashi F, Kaneko K, Saito T. Proteomic signatures corresponding to the SS18/SSX fusion gene. Oncotarget 9:37509-37519 2018 *corresponding author †equal first
59. Sano K, Suehara Y*, Tanabe Y, Okubo T, Kim Y, Ishii M, Kawasaki T, Terakado A, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K. The first study on locomotive syndrome in lower amputees. J Adv Med Med Res. 27(5): 1-10, 2018 *corresponding author
60. Akaike K, Suehara Y*†, Kohsaka S, Hayashi T, Tanabe Y, Kazuno S, Mukaihara K, Ishii M, Kurihara T, Youngji K, Okubo T, Hayashi Y, Takamochi K, Takahashi F, Kaneko K, Ladanyi M, Saito T. PPP2R1A regulated by PAX3/FOXO3 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma. Oncotarget 9:25206-25215, 2018) *corresponding author †equal first
61. Akazawa Y, Saito T, Hayashi T, Yanai Y, Tsuyama S, Akaike K,Suehara Y, Takahashi F, Takamochi K, Murakami T, Watanabe S, Yao T. A comprehensive clinicopathological analysis of gastric adenocarcinoma with enteroblastic differentiation using next generation sequencing with emphasis on the distinction from socalled hepatoid adenocarcinoma. Human Pathology 78, 79-88, 2018)
62. Suehara Y, Akaike K, Mukaihara K, Kurisaki-Arakawa A, Kubota D, Okubo T, Mitomi H, Mitani K, Takahashi M, Toda-Ishii M, Taguchi T, Takagi T, Kaneko K, Yao T, Saito T. KCTD12 may be negatively regulated by KIT in gastrointestinal stromal tumors. Oncotarget 9:27016-27026, 2018
63. Tanabe Y, Suehara Y*†, Kim Y, Nojiri S, Okubo T, Ishii M, Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Okubo N, Saito T, Kaneko K. An The development of the short-form “25-question Geriatric Locomotive Function Scale”. J Adv Med Med Res. 25(10): 1-13, 2018 *corresponding author †equal first
64. Tanabe Y, Suehara Y*, Kohsaka S, Hayashi T, Akaike K, Mukaihara K, Kurihara T, Kim Y, Okubo T, Ishii M, Kazuno S, Kaneko K, Saito T. IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcomas. Oncotarget 9:14428-14443. 2018 *corresponding author
65. Hayashi T, Takamochi K, Yanai Y, Mitani K, Tomita H, Mogushi K, Suehara Y, Takahashi F, Suzuki K, Saito T, Yao T. Non-small cell lung carcinoma with diffuse co-expression of thyroid transcription factor-1 and ΔNp63/p40. Human Pathology S0046-8177(18)30037-6. 2018
66. Kohsaka S, Saito T, Akaike K, Suehara Y, Hayashi T, Takagi T, Kaneko K, Ueno T, Kojima S, Kohashi K, Mano H, Oda Y, Yao T. Pediatric soft tissue tumor of the upper arm with LMNA-NTRK1 fusion. Human Pathology 2018 72:167–173
67. Kohsaka S, Nagano K, Ueno T, Suehara Y, Hayashi T, Shimada N, Takahashi K, Suzuki K, Takamochi K, Takahashi F, Mano H. High-throughput functional evaluation of variants of unknown significance in EGFR. Science Translational Medicine 2017 9, (416): eaan6566
68. Suehara Y. Development of Novel Therapeutic Strategies in Cancers and Sarcomas. Juntendo Medical Journal 63(2), 95-97. 2017
69. Takamochi K, Takahashi F, Suehara Y, Sato E, Kohsaka S, Hayashi T, Kitano S, Takeuchi K, Mano H, Suzuki K. Is DNA mismatch repair deficiency status a biomarker for immune checkpoint inhibitors in lung adenocarcinoma patients?: Microsatellite instability analysis using the Promega panel. Lung Cancer 2017 110, 26–31
70. Mukaihara K, Tanabe Y, Kubota D, Akaike K, Hayashi T, Mogushi K, Hosoya M, Sato S, Kobayashi K, Okubo T, Kim Y, Kohsaka S, Saito T, Kaneko K, Suehara Y*. Cabozantinib and dastinib exert anti-tumor activity in alveolar soft part sarcoma. PLOS ONE 2017 12(9): e0185321. *corresponding author
71. Suehara Y*, Imashimizu K, Miyamoto N, Uehara H, Tanabe Y, Hattori N, Suzuki K, Saito T, Kaneko K. Arterial Thoracic Outlet Syndrome (aTOS) and Cerebellar Infarction Following a Stress Fracture of the First Rib and Extensive Callus: A case report. J Bone Joint Surg. Case Connector 2017 7 (3) e64 *corresponding author
72. Saito T, Akaike K, Tomomasa R, Suehara Y, Takagi T, Kaneko K, Yao T. A case of epithelioid hemangioma of the right third rib in a 55-year-old man. Int J Clin Exp Pathol. 2016 9(9): 9681-9686
Tomomasa R, Akaike K, Asahina M, Toda-Ishii M, Yashiro D, Suehara Y, Takagi T,
73. Kaneko K, Yao T, Saito T. A case of secondary chondrosarcoma with TP53 mutation arising from fibrous dysplasia. Int J Clin Exp Pathol . 2016; 9(7): 7230-7236
74. Kim Y, Suehara Y*, Ishii M, Kawasaki T, Matsuoka K, Okubo T, Okubo N, Tanabe Y, Akaike K, Mukaihara K, Kubota D, Maruyama Y, Saito T, Kaneko K. A comparative study of 2 screening tools for locomotive syndrome (the “Loco-check” and the “GLFS-25”): An orthopedic outpatient-based survey. Br J Med Med Res. 2016 17(5): 1-13 *corresponding author
75. Kageyama S, Yamaguchi S, Ito S, Suehara Y, Saito T, Akaike K, Miura K, Kato S. A case report of using nivolumab for a malignant melanoma patient with rheumatoid arthritis. Int Canc Conf J. 2016 5(4) 192–196
76. Kim Y, Kobayashi E, Kubota D, Suehara Y, Mukaihara K, Akaike K, Ito A, Kaneko K, Chuman H, Kawai A, Kitano S. Reduced argininosuccinate synthetase expression in refractory sarcomas. Oncotarget. 2016 7(43) 70832-70844
77. Ishii M, Akaike K, Suehara Y, Mukaihara K, Kubota K , Kohsaka S, Okubo T, Mitani K, Mogushi K, Takagi T, Kaneko K, Yao T, Saito T. Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors. Modern Pathology. 2016 29, 1424–1432
78. Suehara Y*, Osawa H, Kubota D, Kato S, Akaike K, Tanabe Y, Saito T, Kaneko K. Large skin ulcer due to a subcutaneous orthopedic implant after bevacizumab therapy: A case report. J Bone Joint Surg. Case Connector 2016 6 (3): e70. *corresponding author
79. Akaike K, Toda-Ishii M, Suehara Y, Takagi T, Kaneko K,Yao T, Saito T. Paget's sarcoma with sarcoma-specific TP53 mutation arising from a Japanese patient. Int J Clin Exp Pathol . Int J Clin Exp Pathol . 2016 9(3): 3978-3986
80. Tanabe Y, Suehara Y*, Okubo T, Kim Y, Ishii M,Kawasaki T, Matsuoka K, Akaike K, Mukaihara K, Kubota D, Okubo N, Maruyama Y, Saito T, Kaneko K. An Outpatient-based Survey on the Recognition of Locomotive Syndrome in Japan: The Results of three Years of Surveys. Br J Med Med Res. 2016 15(9) BJMMR.26127 1-9. *corresponding author
81. Mukaihara K, Suehara Y*, Kohsaka S, Kubota D, Toda-Ishii M, Akaike K, Fujimura T, Kobayashi E, Yao T, Ladanyi, M, Kaneko K, Saito T. Expression of F-actin-capping protein subunit beta is associated with cell growth and motility in epithelioid sarcoma. BMC cancer. 2016 16(1):206. *corresponding author
82. Mukaihara K, Suehara Y*, Kohsaka S, Kubota D, Akaike K, Ishii M, Fujimura T, Okubo T, Takagi T, Yao T, Kaneko K, Ladanyi M, Saito T. Protein expression profiling of giant cell tumors of bone treated with denosumab. PLoS ONE. 2016 11(2): e0148401. *corresponding author
83. Saito T, Akaike K, Kurisaki Arakawa A, Toda Ishii M, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T. TERT promoter mutations are rare in bone and soft tissue sarcomas of Japanese patients. Molecular and Clinical Oncology. 2016 4(1):61-64.
84. Akaike K, Toda-Ishii M, Suehara Y, Mukaihara K, Kubota D, Mitani K, Takagi T, Kaneko K, Yao T, Saito T. TERT promoter mutations are a rare event in gastrointestinal stromal tumors. SpringerPlus 2015, 4:836
85. Takagi T, Katagiri H, Kim Y, Suehara Y*, Kubota D, Akaike K, Ishii M, Mukaihara K, Okubo T, Murata H, Takahashi M, Kaneko K, Saito T. Skeletal metastasis of unknown primary origin at the initial visit: A retrospective analysis of 286 cases. PLoS ONE. 2015 10(6):e0129428. *corresponding author
86. Toda-Ishii M, Akaike K, Kurisaki-Arakawa A, Arakawa A, Mukaihara K, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. Sarcomatous transformation of EGFR and TP53 mutation-positive metastatic adenocarcinoma of the lungs, masquerading as a primary pleomorphic sarcoma of the proximal femur. Int J Clin Exp Pathol . 2015; 8(3): 3270-3278
87. Akaike K, Suehara Y, Takagi T, Kaneko K, Yamashita A, Yao T, Saito T. Spindle cell lipoma of the wrist, occurring in a distinctly rare location: a case report with review of literature. Int J Clin Exp Pathol . 2015; 8(3): 3299-3303
88. Ishii M, Kim Y, Suehara Y*, Kawasaki T, Matsuoka J, Akaike K, Mukaihara K, Kubota D, Okubo T, Saito T, Takagi T, Kaneko K. The Recognition of Locomotive Syndrome in 2014: A Cross-sectional Study in the Orthopeadic Outpatients in Tokyo. Br J Med Med Res. 2015 6(6) 606-616. *corresponding author
89. Akaike K, Kurisaki-Arakawa A, Hara K, Suehara Y, Takagi T, Mitani K, Kaneko K, Yao T, Saito T. Distinct clinicopathologic features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. Hum Pathol. 2015 46(3): 347-56
90. Kurisaki-Arakawa A, Akaike K, Tomomasa R, Arakawa A, Suehara Y, Takagi T, Kaneko K, Yao T, Saito T. A case of low-grade fibromyxoid sarcoma with unusual central necrosis in a 77-year-old man confirmed by FUS-CREB3L2 gene fusion. International Journal of Surgery Case Reports. 2014 5(12): 1123-1127
91. Lovly CM, McDonald NT, Chen H, Jin H, Lim D, Suehara Y, Wang Lu, Chen X, Lu P, Red-Brewer M, Johnson DH, Horn L, Ladanyi M, Pao W. Rationale for co-targeting IGF-1R and ALK in ALK fusion positive lung cancer. Nature Medicine 2014 20(9): 1027-34
92. Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T. Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature. Diagn Pathol 2014 9(1): 163.
93. Asahina M, Saito T, Arakawa A, Suehara Y, Takagi T, Hisasue S, Kaneko K, Horie S, Yao T. A case of primary spindle cell variant of embryonal rhabdomyosarcoma of the prostate. Int J Clin Exp Pathol. Int J Clin Exp Pathol 2014 7(8):5181-5
94. Akaike K, Suehara Y, Takagi T, Kaneko K, Saito T. Eggshell-like mineralized recurrent lesion in the popliteal region after treatment of giant cell tumor of bone with denosumab. Skeletal Radiol 2014 43(12):1767-72.
95. Kastenhuber ER, Huse JT, Berman SH, Pedraza A, Zhang J, Suehara Y, Viale A, Cavatore M, Heguy A, Szerlip N, Ladanyi M, Brennan CW: Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates. Acta Neuropathologica. 2014 127(5):747-59
96. Toda M, Suehara Y*, Akaike K, Okubo T, Kubota D, Mukaihara K, Kaneko K, Yao T, Takagi T, Saito T. Giant-cell tumor of bone arising in the anterior rib with a positive expression of GPX-1: a case report and review of the literature. Int Canc Conf J 2014 3:178–182. *corresponding author
97. Mukaihara K, Kubota D, Yoshida A, Asano N, Suehara Y, Kaneko K, Kawai A, Kondo T. Proteomic Profile of Epithelioid Sarcoma. J Proteomics Bioinform. 2014 7: 158-165.
98. Okubo T, Suehara Y*, Kawasaki T, Akaike K, Toda M, Okubo N, Kubota D, Mukaihara K, Kim Y, Kaketa T, Homma Y, Shimanouchi N, Saito T, Takagi T and Kaneko K. An Outpatient-based Survey about the Recognition of Locomotive Syndrome and the Results of the Loco-check at a University Hospital in Tokyo. Br J Med Med Res. 2014 4: 3255-3268, 2014. *corresponding author
99. Orita H, Ito T, Sakurada M, Kushida T, Maekawa H, Wada R, Suehara Y, Kubota D, and Sato K. Pfetin as a risk factor of recurrence in gastrointestinal stromal tumors. BioMed Research International 2014 : 651935.
100. Kubota T, Yoshida A, Kikuta K, Saito T, Suehara Y, Gotoh M, Kawai A, Kondo T. Proteomic approach to gastrointestinal stromal tumor identified prognostic biomarkers. J Proteomics Bioinform. 2014 7(1):10-16.
101. Suehara Y*, Kubota D, Saito T. Tissue Sample Preparation for Biomarker Discovery (Methods in Molecular Biology, 2013 1002:13-23 ) *corresponding author
102. Suehara Y*, Kohsaka S, Kubota D, Mukaihara K, Akaike K, Mineki R, Fujimura T , Kaneko K, Ladanyi M, Saito T, Kondo T. Proteomic technologies to develop biomarkers and functional analyses for bone and soft tissue tumors. J Proteomics Bioinform. 2013 S3-001. *corresponding author
103. Drilon A, Wang L, Hasanovic A, Suehara Y, Lipson D, Stephens P, Ross J, Miller V, Ginsberg M, Zakowski MF, Kris MG, Ladanyi M, Rizvi N: Response to Cabozantinib in Patients with RET Fusion-Positive Lung Adenocarcinomas. Cancer Discovery. 2013 3(6):630-5
104. Kondo T, Suehara Y, Kikuta K, Kubota D, Tajima T, Mukaihara K, Ichikawa H, Kawai A; Proteomic approach towards personalized sarcoma treatment: Lessons from prognostic biomarker discovery in gastrointestinal stromal tumor. Proteomics Clin Appl. 2013 7(1-2):70-78
105. Kubota D, Mukaihara K, Yoshida A, Suehara Y, Saito T, Okubo T, Gotoh M, Orita H, Tsuda H, Kaneko K, Kawai A, Kondo T, Sato K, Yao T: The prognostic value of pfetin: A validation study in gastrointestinal stromal tumors using a commercially available antibody. Jpn J Clin Oncol. 2013 43(6):669-75.
106. Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Kaneko K, Yao T: p53 mutations may be involved in malignant transformation of giant cell tumor of bone through interaction with GPX1. Virchows Archiv. 2013 463:67-77.
107. Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K: Desmoplastic fibroma of the rib with cystic change : A case report with review of literature. Skeletal Radiol 2013, 43(5):703-8.
108. Okubo T, Saito T, Takagi T, Torigoe T, Suehara Y, Akaike K, Yao T, Kaneko K: Desmoplastic fibroma of the scapula with fluorodeoxyglucose uptake on positron emission tomography: a case report and literature review. Int J Clin Exp Pathol 2013 15;6:2230-6.
109. Kubota D, Yoshida A, Tsuda H, Suehara Y, Okubo T, Saito T, Orita H, Sato K, Taguchi T, Yao T, Kaneko K, Katai H, Kawai A, Kondo T: Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor. PLos ONE. 2013; 8(8):e73896.
110. Suehara Y, Arcila ME, Wang Lu, Hasanovic A, Ang DC, Ito T, Kimura Y, Drilon A, Guha U, Rusch VW, Kris MG, Zakowski MF, Rizvi NA, Khanin R, Ladanyi M. Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions. Clin Cancer Res. 2012 18(24): 6599-608
111. Suehara Y*, Kubota D, Kikuta K, Kaneko K, Kawai A, Kondo T. Discovery of biomarkers for osteosarcoma by proteomics approaches. Sarcoma. 2012:425636. *corresponding author
112. Saito T, Mitomi H, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Malignant granular cell tumor with unusual long clinical course. An autopsy case with review of literatures. J Cancer Sci Ther. 2012, 4:260-263.
113. Saito T, Mitomi H, Kurisaki A, Torigoe T, Takagi T, Suehara Y, Okubo T, Kaneko K, Yao T. Low-grade myofibroblastic sarcoma of the distal femur. Int J Surg Case Rep, 2012; 4(2): 195-199.
114. Kubota D, Okubo T, Saito T, Suehara Y, Yoshida A, Kikuta K, Tsuda H, Katai H, Shimada Y, Kaneko K, Kawai A, Kondo T. Validation Study on Pfetin and ATP-dependent RNA Helicase DDX39 as Prognostic Biomarkers in Gastrointestinal Stromal Tumour. Jpn J Clin Oncol, 2012 42(8): 730-41
115. Okubo T, Saito T, Mitomi H, Takagi T, Torigoe T, Suehara Y, Katagiri H, Murata H, Takahashi M, Ito I, Yao T, Kaneko K. Intraneural lipomatous tumor of the median nerve: Three case reports with a review of literature. Int J Surg Case Rep, 2012 3(9): 407-411.
116. Torigoe T, Tomita Y, Iwase Y, Aritomi K, Suehara Y, Oukubo T, Sakurai A, Terakado A, Tatsuya T, Kaneko K, Saito T, Yazawa Y. Pedicle freezing with liquid nitrogen for malignant bone tumour in the radius: a new technique of osteotomy of the ulna. Journal of Orthopaedic Surgery, 2012 20(1):98-102
117. Kikuta K, Kubota D, Saito T, Orita H, Yoshida A, Tsuda H, Suehara Y, Katai H, Shimada Y, Toyama Y, Sato K, Yao T, Kaneko K, Beppu Y, Murakami Y, Kawai A, Kondo T. Clinical proteomics identified ATP-dependent RNA helicase DDX39 as a novel biomarker to predict poor prognosis of patients with gastrointestinal stromal tumor. Journal of proteomics, 2012 75(4):1089-98.
118. Suehara Y, Tochigi N, Kubota D, Kikuta K, Nakayama R, Seki K, Yoshida A, Ichikawa H, Hasegawa T, Kaneko K, Chuman H, Beppu Y, Kawai A, Kondo T. Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics. Journal of proteomics, 2011 74(6): 829-42.
119. Suehara Y: Proteomic analysis of soft tissue sarcoma. International Journal of Clinical Oncology, 2011 16(2): 727-33.
120. Saito T, Mitomi H, Izumi H, Suehara Y, Okubo T, Torigoe T, Takagi T, Kaneko K, Sato K, Matsumoto T, Yao T. A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. Hum Pathol. 2011 42(5): 727-33.
121. Saito T, Mitomi H, Suehara Y, Okubo T, Torigoe T, Takagi T, Kaneko K, Yao T. A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. Pathology Research and Practice, 2011 207(10):664-9.
122. Kubota D, Orita H, Yoshida A, Gotoh M, Kanda T, Tsuda H, Hasegawa T, Katai H, Shimada Y, Suehara Y, Kikuta K, Sato K, Tochigi N, Seki K, Shibata T, Toyama Y, Beppu Y, Kaneko K, Kawai A, Kondo T Pfetin as a Prognostic Biomarker for Gastrointestinal Stromal Tumor: Validation Study in Multiple Clinical Facilities. Jpn J Clin Oncol, 2011 41(10): 1194-1202.
123. Torigoe T, Terakado A, Suehara Y, Okubo T, Takagi T, Kaneko K, Yazawa Y: Metastatic Soft Tissue Tumors. Journal of Cancer Therapy, 2011 2(5): 746-751.
124. Torigoe T, Terakado A, Suehara Y, Okubo T, Takagi T, Kaneko K, Yazawa Y. The surgical Treatment and Outcome of Pathological Fracture in Patients with Giant Cell Tumor of Bone. Surgical Science, 2011 2(5):228-231.
125. Suehara Y*, Nozawa M, Kim SG, Nagayama M, Kojima T, Torigoe T, Kubota D, Yazawa Y, Takagi T, Matsumoto T. Late recurrence of giant cell tumor of bone after adjuvant treatment. J Orthop Surg. 2010 18(1): 122-5. *corresponding author
126. Kikuta K, Gotoh M, Kanda T, Tochigi N, Shimoda T, Hasegawa T, Katai H, Shimada Y, Suehara Y, Kawai A, Hirohashi S, Kondo T. Pfetin as a Prognostic Biomarker in Gastrointestinal Stromal Tumor: Novel Monoclonal Antibody and External Validation Study in Multiple Clinical Facilities. Jpn J Clin Oncol, 2010 40(1): 60-72)
127. Kikuta K, Tochigi N, Saito S, Shimoda T, Morioka H, Toyama Y, Hosono A, Suehara Y, Beppu Y, Kawai A, Hirohashi S, Kondo T. Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics. Proteomics Clin Appl, 2010 4(5) 560-567.
128. Torigoe T, Terakado A, Suehara Y, Kurosawa H, Yazawa Y, Takagi T. Bone versus soft-tissue sarcomas in the elderly. J Orthop Surg. 2010 18(1): 58-62
129. Suehara Y, Kikuta K, Nakayama R, Tochigi N, Seki K, Ichikawa H, Fujii K, Hasegawa T, Shimoda T, Kurosawa H, Chuman H, Beppu Y, Kawai A, Hirohashi S, Kondo T. GST-P1 as a histological biomarker of synovial sarcoma revealed by proteomics. Proteomics Clin Appl, 2009 3(5), 623-634
130. Suehara Y, Kikuta K, Nakayama R, Fujii K, Ichikawa H, Shibata T, Seki K, Hasegawa T, Gotoh M, Tochigi N, Shimoda T, Shimada Y, Sano T, Beppu Y, Kurosawa H, Hirohashi S, Kawai A, KondoT. Anatomic site-specific proteomic signatures of gastrointestinal stromal tumors. Proteomics Clin Appl, 2009 3(5), 584-59.
131. Suehara Y, Kondo T, Seki K, Shibata T, Fujii K, Gotoh M, Hasegawa T, Shimada Y, Sasako M, Shimoda T, Kurosawa H, Beppu Y, Kawai A, Hirohashi S. Pfetin, as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics. Clin Cancer Res 2008 14: 1707-1717.
132. Suehara Y, Kondo T, Seki K, Shibata T, Fujii K, Gotoh M, Hasegawa T, Shimada Y, Sasako M, Shimoda T, Kurosawa H, Beppu Y, Kawai A, Hirohashi S. Pfetin predicts outcome for patients with gastrointestinal stromal tumors. Nature Clinical Practice Oncology 2008 5(7), 364-365.
133. Kawai A, Kondo T, Suehara Y, Kikuta K, Hirohashi S. Protein-expression profiles associated with clinicopathological features of bone and soft tissue sarcomas. Clin Orthop Relat Res. 2008 466(9):2099-2106.
134. Torigoe T, Terakado A, Suehara Y, Kurosawa H. Xanthoma of bone associated with lipoprotein lipase deficiency. Skeletal Radiol. 2008 37(12):1153-1156.
135. Kobayashi E, Kawai A, Endo M, Suehara Y, Takeda K, Nakatani F, Asano T, Sakuraba M, Chuman H, Seki K, Beppu Y. Myxoinflammatory fibroblastic sarcoma. J Orthop Sci. 2008 13(6):566-571.
136. Suehara Y, Kondo T, Fujii K, Hasegawa T, Kawai A, Seki K, Beppu Y, Nishimura T, Kurosawa H, Hirohashi S. Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas. Proteomics 15: 4402-4409, 2006.
137. Suehara Y, Yazawa Y, Hitachi K: Clear cell sarcoma arising from the chest wall. J Orthop Sci. 2004; 9: 171-174.
138. Suehara Y, Yazawa Y, Hitachi K: Intra-abdominal desmoplastic small round cell tumor. The result of ifosfamide-based chemotherapy. Int J Clin Oncol. 2004; 9: 134-138.
139. Suehara Y, Yazawa Y, Hitachi K, Yazawa M. Periosteal osteosarcoma with secondary bone marrow involvement. J Orthop Sci. 2004; 9: 646-649.
140. Suehara Y, Yazawa Y, Hitachi K: Metastatic Bednar tumor with fibrosarcomatous change. J Orthop Sci. 2004; 9: 662-665.

「英文総説」
1. Suehara Y, Kondo T. Pfetin predicts outcome for patients with gastrointestinal stromal tumors. Nat Rev Clin Oncol. 5: 364-365, 2008, doi.org/10.1038/ncponc1143
2. Suehara Y*. Development of novel therapeutic strategies in cancers and sarcomas. Juntendo Medical Journal 63, 95-97. 2017 *corresponding author (IF: none)

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